Disclosed herein are compositions, systems, and methods for diagnosing, treating, and/or ameliorating the symptoms of conditions and diseases associated with abnormal ATP8B1 function. The disclosed compositions, systems, and methods are based on the discovery that ATP8B1 demonstrates PIP2 flippase activity and is implicated in a number of inflammatory conditions and diseases, including progressive familial intrahepatic cholestasis type 1 (PFIC1).
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
2.
MULTI-TIERED DRIVER ALLOCATION OPTIMIZATION FRAMEWORK FOR OMNICHANNEL COMMERCE
A multi-tiered optimization and machine learning framework is provided in which operational decisions as far as driver capacity allocation are taken at three different levels or stages, namely, long-term, short-term, and real-time. While decisions at each stage have individual importance for the operations at different time horizons, this framework utilizes decisions upstream to inform better results downstream. This synergy helps improve allocations when compared to solutions that assign driver capacity for each stage individually.
An exoskeleton system includes a pelvis link configured to be attachable to a pelvic portion of a human body; a first ankle link configured to be attachable to an ankle portion of a first leg of the human body; and a first force transmission system connected to the pelvis link and the first ankle link. The force transmission system includes a first Bowden cable, the Bowden cable comprising a tension cable and a cable sheath extending around at least a portion of the tension cable.
An industrial controller implements a closed-loop control technique referred to as generic PID control, or GPID, which makes explicit the basic principles and methods of quantitatively combining the past, present and future in controller design and tuning. Generic PID control is backward compatible in design and in tuning with current industrial control software interfaces, and as such can be easily adopted onto existing control systems. Generic PID is also widely applicable to artificial intelligence (AI) and data analytics, such as machine learning, where error-correction is core to all algorithms.
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
An industrial controller implements a closed-loop control technique referred to as generic PID control, or GPID, which makes explicit the basic principles and methods of quantitatively combining the past, present and future in controller design and tuning. Generic PID control is backward compatible in design and in tuning with current industrial control software interfaces, and as such can be easily adopted onto existing control systems. Generic PID is also widely applicable to artificial intelligence (AI) and data analytics, such as machine learning, where error-correction is core to all algorithms.
G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
An actuating assembly including a first actuating device, a second actuating device, and an adjustment mechanism. The first actuating device is configured to provide an output torque to a first portion of a user, and the second actuating device is configured to provide an output torque to a second portion of the user. The adjustment mechanism is connected to the first and second actuating devices. The adjustment mechanism is configured to adjust a distance between the first and second actuating devices.
A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
7.
PROCESS FOR REMOVING CARBON DIOXIDE FROM ACETYLENE USING CHA-TYPE ZEOLITE MEMBRANE
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
Inventor
Berdis, Anthony, J.
Sutton, Mark
Tsuji, Brian
Abstract
Antibiotic-resistant artificial nucleosides may be used in combination with antibiotics. The artificial nucleosides may be selected from: (I), (II), (III),(IV) wherein R is as defined herein.
A tumor resection process includes the administration of an iridium-containing nucleoside, medical imaging, and tumor and tumor margin removal. The iridium-containing nucleoside may be selected from:
A tumor resection process includes the administration of an iridium-containing nucleoside, medical imaging, and tumor and tumor margin removal. The iridium-containing nucleoside may be selected from:
An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l)
An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l)
An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l)
wherein R1 is selected from the group consisting of OH, O-acetyl, N3, OCOCH2X1 and NHCOCHX1; X1 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R2 is H or COCH2X2; X2 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R3 is selected from the group consisting of H, OH, COCH2X3 and OCOCH2X3; X3 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanoal; R4 is selected from the group consisting of H, OH, a C1-C6 alkyl group, and CH2X4; and X4 is H or a C1-C6 alkyl group.
The present invention teaches a method of pairing two user worn devices including collecting first and second biometric activity from respective first and second user worn devices to create first and second biometric signals, processing the first and second biometric signals to create first and second keys and determining if the keys match to allow for pairing of the two user worn devices. The first and second biometric activity may be the same or different biometric activities. The processing of the biometric signals is adjusted based upon the types of biometric activities being sensed.
H03M 13/15 - Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
Therapeutic compositions and methods for treating a patient having sickle cell anemia or beta-thalassmia by administering, in therapeutically effective amounts, a composition of an effective amount of an inhibitor of Pumilio-1.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
41 - Education, entertainment, sporting and cultural services
Goods & Services
educational services, namely, providing courses of instruction at the undergraduate, graduate, post graduate, and professional level and distribution of course materials in connection therewith; lending libraries; extension, continuing and community educational services, namely, conducting classes, public lectures, workshops, seminars, conferences and exhibitions in the fields of engineering, law, business, arts and humanities, natural and physical sciences, architecture, journalism, education, international and public affairs, public health, social work, behavioral sciences, and mathematics and distributing course material therewith; educational research; entertainment services, namely, arranging and conducting athletic events and tournaments, exhibitions, conferences, live performances and festivals; entertainment services, namely, arranging, organizing, conducting and hosting social events in the nature of parties, gatherings and workshops for students, alumni, and community members
14.
INFECTION-RESISTANT AND BIOACTIVE INTERBODY DEVICE, AND ASSOCIATED COMPOSTION AND METHOD
An article (e.g., an interbody device) contains a polymer (e.g., polyetheretherketone (PEEK)) and transition metal-doped amorphous magnesium phosphate.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
Disclosed is a system and method for processing data using blockchain technology. The system includes a memory having programmable instructions stored thereon that, when executed by a processor, cause the system to: authenticate one or more sensors in anticipation of receiving component data; receive component data, upon successful authentication; store the component data locally or to a cloud-based server and/or calculate a root value for the component data; store or embed the root value with the stored component data; condense the component data and link the condensed component data to the stored component data via the root value. The system further includes instructions to log the condensed data, including the root value, to a ledger, and to identify a tag or transaction id corresponding to the logging event for subsequent retrieval of the condensed data using the tag or transaction id.
The present exemplary embodiments relate to a privacy preserving approach to peak load management. It finds example application in conjunction with, for example, power systems, such as smart homes, smart buildings, microgrids, distribution systems and bulk systems, and energy management systems.
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor
19.
Compositions and methods for modulating HEXIM1 expression
A method of inducing HEXIM1 expression in cells of a subject includes administering to the cells a compound having the formula,
and pharmaceutically acceptable salts thereof.
A method for producing an aligned boron nitride nanotube film includes drying a dispersion containing boron nitride nanotubes, a biopolymer, and a solvent.
B05D 7/24 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
B82Y 40/00 - Manufacture or treatment of nanostructures
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.
A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.
Methods and systems for improving healthcare through community engagement are provided. In one embodiment, a method includes initializing a community health application on a computing device for an engagement session with a candidate patient. A client identification sequence is performed using the application to enroll the candidate patient as a new community health client or lookup the candidate patient as an existing community health client. Certain client information is collected from the community health client via interaction with the computing device by a healthcare facilitator during the engagement session. The community health application controlling the computing device by presenting displays and reading data in relation to the displays. The client information is processed to select a clinical sequence for the engagement session with the community health client based on the client information. In another embodiment, the method is directed to processing and distribution of the client information to third parties.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
G06F 16/9535 - Search customisation based on user profiles and personalisation
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
H04L 29/06 - Communication control; Communication processing characterised by a protocol
Disclosed are methods of detecting biomarkers in complex biological matrices. The method comprises providing a sample well coated with antibodies specific to target protein biomarker(s), contacting the sample well with a biological sample to capture target biomarkers, digesting target biomarkers, and analyzing the signature peptides resulting from digestion of target biomarkers to determine the amount of one or more protein biomarkers by a mass spectrometry method.
Midcontinent Independent System Operator, Inc. (USA)
Cleveland State University (USA)
Inventor
Ye, Hongxing
Wang, Fengyu
Zhang, Shubo
Rose, Stephen M.
Chen, Yonghong
Ma, Yaming
Abstract
The present disclosure pertains to a system that may be configured to operate a power grid, including generation participants, consumers, and a controller that administers a market for the power generation participants and the consumers on the power grid. The operation of the power grid may include: performing power grid coordination calculations based upon, at least in part, constraints that pertain to the flow and/or congestion of power on the grid; and managing the coordination calculations by reducing a number of constraints used in the coordination calculations, the managing including a first step of coarse screening of the constraints, a second step of deterministic fine screening of the constraints, and a third step of statistical fine screening of the constraints. This second step may cause identification of constraints that are redundant and/or dominated by other constraints.
Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with automatic registration are disclosed. To register for tracking, consenting human subjects wear beacons that emit a beacon signal. During a predefined timing window, beacon signals are detected and compared to a predefined signal-strength threshold and compared to the signal strength of other different beacon signals detected during the same timing window. At the end of the timing window, the strongest beacon signal above the threshold is selected for registration. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, feedback is delivered in real-time to the tracked human subject.
A rotation monitoring system may be attached to a limb and can identify ranges of motion that are associated with injuries or poor performance. In some embodiments, the device is designed to monitor flexion and orientation of joints and limbs, developed specifically around identifying stress concentrating behavior on the ACL. Tests performed show that the designed device can read flexion and orientation of the knee, is durable enough to be used in real-world conditions, and does not impede on the subject's movements.
An augmented reality (AR) authentication method and system provides an AR environment that is presented on a display. The AR environment combines real-world object images captured by a camera with computer generated virtual icons. The virtual icons may be “mapped” to the real-world objects, whereupon the real-world objects take on the characteristics of the mapped images. During an authentication process, a user interacts with the AR environment by a variety of techniques to enter their passcode. Such interaction may include physically moving objects in the real-world so that such movement is reflected in the AR environment; controlling the “mapped” real-world objects through user interaction with the AR environment via an input device; and controlling the virtual icons through user interaction with the AR environment via the input device. Accordingly, if the user interacts with the AR environment in a manner that matches their previously “set” passcode the user is authenticated.
An exoskeleton system is passively powered and pneumatically operated. The system may be a lower-limb system for walking gait restoration. The system may include a first linear actuator located in front of an upper leg section and a second linear actuator located behind a lower leg section.
Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with real-time haptic feedback. The system and method described in this disclosure employing a registration process for consenting human subjects before their activities are monitored. The registration process involves the corroboration of human motion captured in different modalities, i.e., computer-vision-based via the programmable computer-vision-based motion sensor and accelerometer-based via the wearable device. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, haptic feedback is delivered in real-time to the tracked human subject via the wearable device worn by the caregiver.
A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.
Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.
An actuating device for orthosis including a housing, a motor, a transmission disposed in the housing, and an actuating arm. The transmission is operatively connected to the motor such that the motor provides power to the transmission. The transmission includes a first stage, a second stage, and a third stage. The first stage has a first sprocket, a second sprocket, and a first drive belt tensioned between the first sprocket and the second sprocket. The first sprocket is attached to a shaft of the motor. The second stage has a third sprocket, a fourth sprocket, and a second drive belt tensioned by the third sprocket and the fourth sprocket. The third sprocket is attached to the second sprocket of the first stage. The third stage has a fifth sprocket, a sixth sprocket, and a third drive belt tensioned by the fifth sprocket and the sixth sprocket. The fifth sprocket is attached to the fourth sprocket of the second stage. The transmission additionally includes a first shaft and a second shaft. The second sprocket, the third sprocket, and the sixth sprocket are attached to the first shaft, and the fourth sprocket and the fifth sprocket are attached to the second shaft. The actuating arm is operatively connected to the sixth sprocket of the third stage of the transmission such that the power provided to the transmission by the motor causes the actuating arm to provide an output torque.
A61H 1/02 - Stretching or bending apparatus for exercising
A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
F16H 7/08 - Means for varying tension of belts, ropes, or chains
F16H 7/02 - Gearings for conveying rotary motion by endless flexible members with beltsGearings for conveying rotary motion by endless flexible members with V-belts
An actuating device for orthosis includes a transmission that is operatively connected to a motor such that the motor provides power to the transmission. The transmission includes a first stage, a second stage, and a third stage. Each of these stages includes at least two sprockets and a drive belt tensioned between the two sprockets. The transmission also includes a first shaft and a second shaft. A sprocket of each of the first, second, and third stages of the transmission is attached to the first shaft. An actuating arm is operatively connected to the third stage of the transmission such that the power provided to the transmission by the motor causes the actuating arm to provide an output torque.
H02K 11/33 - Drive circuits, e.g. power electronics
H02K 11/20 - Structural association of dynamo-electric machines with electric components or with devices for shielding, monitoring or protection for measuring, monitoring, testing, protecting or switching
A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
F16H 19/00 - Gearings comprising essentially only toothed gears or friction members and not capable of conveying indefinitely-continuing rotary motion
A61H 1/02 - Stretching or bending apparatus for exercising
F16H 7/08 - Means for varying tension of belts, ropes, or chains
F16H 7/02 - Gearings for conveying rotary motion by endless flexible members with beltsGearings for conveying rotary motion by endless flexible members with V-belts
36.
Authentication method for a computing device using interactive game board and game piece images
An authentication method and system includes a computing device, such as a smart phone, which includes a display for presenting a graphical and interactive game board that is used for entering a user's passcode. During the authentication process, the user selects a game board (e.g. chess, checkers, poker, backgammon, etc.) and associated game pieces for presentation on the display. The user then moves one or more game pieces to locations on the game board. Together, the selected game board, selected game pieces, and the movements and/or locations which the game pieces are moved on the game board form an entered passcode. This generated passcode is then compared with a stored passcode to authenticate the user before granting access to the computing device.
G06F 21/36 - User authentication by graphic or iconic representation
G06F 21/45 - Structures or tools for the administration of authentication
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
G06F 3/04883 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser using a touch-screen or digitiser, e.g. input of commands through traced gestures for inputting data by handwriting, e.g. gesture or text
G09C 5/00 - Ciphering or deciphering apparatus or methods not provided for in other groups of this subclass, e.g. involving the concealment or deformation of graphic data such as designs, written or printed messages
A shoulder-surfing resistant authentication method and system includes a computing device, such as a smart phone, which includes a display for presenting an interactive virtual environment. During the authentication process, the user enters a passcode by modifying one or more attributes of one or more icons that are presented relative to the interactive environment. Such attributes may include one or more of the type of movement the icons perform, the change in position or visual characteristics of the icons relative to the virtual environment, as well as the removal and/or addition of one or more icons relative to the virtual environment. The entered passcode is then compared with a previously stored or “set” passcode to authenticate the user before granting access to the computing device.
G06F 21/36 - User authentication by graphic or iconic representation
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
G06F 3/0481 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar-insertion hole, a membrane cassette, and a reservoir well.
A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar- insertion hole, a membrane cassette, and a reservoir well.
A method of creating a miniature multicellular biological construct and a method for studying cellular environments using the miniature multicellular biological construct is provided. The method for making the miniature multicellular biological construct includes suspending cells in a hydrogel, depositing the cell-suspension into a microwell, gelling the cell-suspension, and incubating the cell-suspension. The method for studying cellular environments includes imaging the miniature multicellular biological construct.
A method of creating a miniature multicellular biological construct and a method for studying cellular environments using the miniature multicellular biological construct is provided. The method for making the miniature multicellular biological construct includes suspending cells in a hydrogel, depositing the cell-suspension into a microwell, gelling the cell-suspension, and incubating the cell-suspension. The method for studying cellular environments includes imaging the miniature multicellular biological construct.
During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with real-time haptic feedback. The system and method described in this disclosure employing a registration process for consenting human subjects before their activities are monitored. The registration process involves the corroboration of human motion captured in different modalities, i.e., computer-vision-based via the programmable computer-vision-based motion sensor and accelerometer-based via the wearable device. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, haptic feedback is delivered in real-time to the tracked human subject via the wearable device worn by the caregiver.
When forming ultra-conductive wire, multi-walled carbon nanotubes (MWCNTs) are dispersed and de-agglomerated in hot metal. The MWCNTs are dispersed in a precursor matrix via mixing and sintering to form precursor material, which is hot-extruded multiple rounds at a predetermined temperature to form a nano-composite material. The nano-composite material is inserted into a metal bar to form a nano-composite billet (306), which is subjected to multiple rounds of hot extrusion to form an ultra-conductive material. The ultra-conductive material is subjected to one or more rounds of hot wire drawing to form an ultra-conductive wire comprising a nano-composite filament.
B21C 37/04 - Manufacture of metal sheets, rods, wire, tubes, profiles or like semi-manufactured products, not otherwise provided forManufacture of tubes of special shape of rods or wire
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
B22F 3/16 - Both compacting and sintering in successive or repeated steps
B22F 3/20 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor by extruding
B22F 7/06 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools
B30B 11/26 - Extrusion pressesDies therefor using press rams
C22C 47/14 - Making alloys containing metallic or non-metallic fibres or filaments by powder metallurgy, i.e. by processing mixtures of metal powder and fibres or filaments
C22C 49/02 - Alloys containing metallic or non-metallic fibres or filaments characterised by the matrix material
H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys
B30B 11/00 - Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses or tabletting presses
41 - Education, entertainment, sporting and cultural services
Goods & Services
Business consulting services in the field of innovation, entrepreneurship, sales, business development, and global business strategies; arranging and conducting business meetings in the field of innovation, entrepreneurship, sales, business development, and global business strategies Educational services, namely, conferences, workshops, meetings, and lectures regarding innovation, entrepreneurship, sales, business development, and global business strategies and distribution of written and electronic materials therewith
47.
METHODS FOR THE DEVELOPMENT OF COMMERCIAL SCALE NANO-ENGINEERED ULTRACONDUCTIVE COPPER WIRE
When forming ultra-conductive wire, multi-walled carbon nanotubes (MWCNTs) are dispersed and de-agglomerated in hot metal. The MWCNTs are dispersed in a precursor matrix via mixing and sintering to form precursor material, which is hot- extruded multiple rounds at a predetermined temperature to form a nano-composite material. The nano-composite material is inserted into a metal bar to form a nano- composite billet (306), which is subjected to multiple rounds of hot extrusion to form an ultra-conductive material. The ultra-conductive material is subjected to one or more rounds of hot wire drawing to form an ultra-conductive wire comprising a nano- composite filament.
B22F 3/20 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor by extruding
B22F 7/06 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools
B30B 7/04 - Presses characterised by a particular arrangement of the pressing members wherein pressing is effected in different directions simultaneously or in turn
B30B 11/26 - Extrusion pressesDies therefor using press rams
B21C 37/04 - Manufacture of metal sheets, rods, wire, tubes, profiles or like semi-manufactured products, not otherwise provided forManufacture of tubes of special shape of rods or wire
H01L 39/24 - Processes or apparatus specially adapted for the manufacture or treatment of devices provided for in group or of parts thereof
H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys
B22F 3/16 - Both compacting and sintering in successive or repeated steps
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
C22C 47/14 - Making alloys containing metallic or non-metallic fibres or filaments by powder metallurgy, i.e. by processing mixtures of metal powder and fibres or filaments
C22C 49/02 - Alloys containing metallic or non-metallic fibres or filaments characterised by the matrix material
An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10-21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
printed materials, namely, brochures and manuals in the field of continuing legal education; decals; business card holders, stationery, pens, pencils, notebooks, and paperweights educational services, namely, providing courses of instruction at the graduate, post graduate, and professional level and distribution of course materials in connection therewith; entertainment services, namely, arranging, organizing, conducting and hosting social events in the nature of parties, gatherings and workshops for students, alumni, and community members
−21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Nano-composite structures are formed by pre-loading carbon nanotubes (CNTs) into at least one of a plurality of channels running the length of a cartridge, placing the pre-loaded cartridge in a piston chamber of a die-casting machine, creating a vacuum therein, and filing the piston chamber with molten metal to soak the pre-loaded cartridge and fill empty cartridge channels. Pressure is applied via the piston to eject the carbon nanotubes and molten metal from the cartridge channels and inject the nano-composite mixture into a rod-shaped die cavity. The internal diameter of the cavity is equal to or less than the final diameter of the nozzle. The nano-composite mixture is cooled to form a solid nano- composite rod having the first predetermined diameter, wherein the carbon nanotubes are aligned in a non-random manner. Furthermore, drawing down the nano-composite rod to smaller diameter wire further disperses the nanotubes along the length of the wire.
The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ra is a benzyl group with alkyl and/or alkoxy; Rb is selected from H and alkyl groups; Rf is an alkyl; and R3 is selected from a (Formula) substituted phenyl, a heterocyclic group, and, Formula, wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group. Formula (I)
The invention provides an electrode and an electrochemical device including the electrode. The electrode comprises a spatial confining structure such as grooves and an active compound such as glucose oxidase (GOx). The grooves spatially confines GOx, and stabilizes its enzymatic activity. Also provided is a method of stabilizing the activity of an active compound such as GOx. The invention can be widely used in development of an energy-generation device such as a fuel cell, a memory, an electrochemical reactor, a supercapacitor, a biosensor and a medical device thereof such as artificial pancreas, and a sensor such as detector of redox reactant.
The invention provides a simple, inexpensive, accurate, and rapid method of measuring particle settling velocity comprising: (i) providing a gravity settler such as a column; (ii) filling the column with a first homogenous particle suspension, wherein the particle concentration in the first homogenous particle suspension is X1, (iii) separating the column into an upper sub-column and a lower sub-column with a height h after settling the first homogenous particle suspension for a period of time t, wherein some particles remain in the upper sub-column; (iv) removing the particle suspension in the upper sub-column and mixing the particle suspension confined in the lower sub-column with a height h to prepare a second homogenous particle suspension; (v) measuring the particle concentration in the second homogenous particle suspension X2; and (vi) determining the particle settling velocity v with the formula: v = h(X2-X1)ltX1. Also provided are device and system for carrying out the method.
G01P 5/20 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the time taken by the fluid to traverse a fixed distance using particles entrained by a fluid stream
G01P 5/00 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft
A wind harnessing system comprises a substantially helical structure including at least a portion of a spiraling groove and at least one energy converter positioned at least partially within the portion of the spiraling groove. In other embodiments, wind grooves formed by adjacent bands which are fixed with respect to one another, carry energy converters which are moveable with respect to these fixed bands.
−21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
C12M 1/00 - Apparatus for enzymology or microbiology
A biocompatible coating is described. The coating comprises the enzyme Nitric Oxide Synthase that releases nitric oxide or results in the release of nitric oxide, and a biocompatible matrix incorporating the Nitric Oxide Synthase enzyme. The coating can be applied to medical devices. Various examples of compositions, materials, methods and devices using or otherwise associated with such coatings are also disclosed.
An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10~21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.
Inhibitors of casein kinase 2 are described that have been found to arrest uncontrolled cell proliferation, thereby suggesting their use in cancer treatment strategies. Specific applications include treating breast cancer, colon cancer, melanoma, chronic myelogenous leukemia, bladder cancer, renal cancer, and brain cancer. Various methods and compositions utilizing the inhibitors are described.
Methods for simultaneously surveying the status of a large number of DNA mutation markers are described. In addition, methods for simultaneously determining the methylation status at multiple sites of a collection of genes, in a single assay, are described.
An electrical energy generating system converts wind power to electrical power with a wind deflecting structure that divides wind impinging on the structure into two separate accelerated flow paths. One or more turbines are positioned in proximity to the wind deflecting structure such that a portion of the vanes of the turbine is placed within one of the accelerated flow paths. An energy converter is coupled to the turbine that converts rotary motion of the turbine into electricity.
F03D 9/00 - Adaptations of wind motors for special useCombinations of wind motors with apparatus driven therebyWind motors specially adapted for installation in particular locations
F03D 1/02 - Wind motors with rotation axis substantially parallel to the air flow entering the rotor having a plurality of rotors
An electrical energy generating system converts wind power to electrical power with a wind deflecting structure that divides wind impinging on the structure into two separate accelerated flow paths. One or more turbines are positioned in proximity to the wind deflecting structure such that a portion of the vanes of the turbine is placed within one of the accelerated flow paths. An energy converter is coupled to the turbine that converts rotary motion of the turbine into electricity.
A wind harnessing system comprises a substantially grooved shell disposed about a rigid frame. The grooved shell can be constructed of lightweight shell panels connected to one another and to the frame. Alternatively, the grooved shell can be constructed of inflatable shell sections.
F03D 9/00 - Adaptations of wind motors for special useCombinations of wind motors with apparatus driven therebyWind motors specially adapted for installation in particular locations
H02P 9/04 - Control effected upon non-electric prime mover and dependent upon electric output value of the generator
A wind harnessing system comprises a substantially grooved shell disposed about a rigid frame. The grooved shell can be constructed of lightweight shell panels connected to one another and to the frame. Alternatively, the grooved shell can be constructed of inflatable shell sections.
F03D 1/02 - Wind motors with rotation axis substantially parallel to the air flow entering the rotor having a plurality of rotors
F03D 1/04 - Wind motors with rotation axis substantially parallel to the air flow entering the rotor having stationary wind-guiding means, e.g. with shrouds or channels
66.
HIGH INTENSITY LASER POWER BEAMING RECEIVER FOR SPACE AND TERRESTRIAL APPLICATIONS
Systems and methods are described that facilitate refueling a vehicle (20) with electrical energy by targeting receiver (30) thereon and pointing a high-intensity laser source (70) at the receiver (30). Vertical multi-junction (VMJ) photocells (60) receive the laser energy and convert the laser energy into electrical energy. The laser source (70) can operate at a range of output power levels depending on the vehicle's energy needs. The laser source (70) can be a pulsed or a continuous near- infrared laser source. A heat exchanger (180) can be coupled to the receiver (30) to dissipate laser energy not converted into electrical energy. If the vehicle (20) has a propeller, the heat exchanger (180) can be mounted to the vehicle (20) in the propeller wash path.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Lending libraries; publication of books; publication of electronic books and journals on-line; educational services, namely, providing courses at the undergraduate and graduate university level and distributing course material therewith; extension, continuing and community educational services, namely, conducting classes, public lectures, workshops, seminars, conferences and exhibitions in the fields of engineering, law, business, arts and humanities, natural and physical sciences, architecture, journalism, education, international and public affairs, public health, social work, behavioral sciences, and mathematics and distributing course material therewith; educational research; entertainment services, namely, arranging and conducting athletic events, tournaments and camps, exhibitions, conferences, live performances and festivals
41 - Education, entertainment, sporting and cultural services
Goods & Services
lending libraries; publication of books; publication of electronic books and journals on-line; educational services, namely, providing courses at the undergraduate and graduate university level and distributing course material therewith; extension, continuing and community educational services, namely, conducting classes, public lectures, workshops, seminars, conferences and exhibitions in the fields of engineering, law, business, arts and humanities, natural and physical sciences, architecture, journalism, education, international and public affairs, public health, social work, behavioral sciences, and mathematics and distributing course material therewith; educational research; entertainment services, namely, arranging and conducting athletic events and tournaments, exhibitions, conferences, live performances and festivals
41 - Education, entertainment, sporting and cultural services
Goods & Services
lending libraries; publication of books; publication of electronic books and journals on-line; educational services, namely, providing courses at the undergraduate and graduate university level and distributing course material therewith; extension, continuing and community educational services, namely, conducting classes, public lectures, workshops, seminars, conferences and exhibitions in the fields of engineering, law, business, arts and humanities, natural and physical sciences, architecture, journalism, education, international and public affairs, public health, social work, behavioral sciences, and mathematics and distributing course material therewith; educational research; entertainment services, namely, arranging and conducting athletic events and tournaments, exhibitions, conferences, live performances and festivals
41 - Education, entertainment, sporting and cultural services
Goods & Services
lending libraries; publication of books; publication of electronic books and journals on-line; educational services, namely, providing courses at the undergraduate and graduate university level and distributing course material therewith; extension, continuing and community educational services, namely, conducting classes, public lectures, workshops, seminars, conferences and exhibitions in the fields of engineering, law, business, arts and humanities, natural and physical sciences, architecture, journalism, education, international and public affairs, public health, social work, behavioral sciences, and mathematics and distributing course material therewith; educational research; entertainment services, namely, arranging and conducting athletic events and tournaments, exhibitions, conferences, live performances and festivals
41 - Education, entertainment, sporting and cultural services
Goods & Services
educational services, namely, courses at the undergraduate and graduate university level and distributing course material therewith; extension, continuing, and community educational services, namely, conducting classes, lectures, workshops, seminars, conferences, exhibitions, and camps in the field of athletics; entertainment services, namely, arranging and conducting athletic events, tournaments, exhibitions, and conferences
Electrodes comprising ruthenium oxide nanoparticles are disclosed. The ruthenium oxide nanoparticles are located within the electrode or as a coating thereon. The electrode is especially suited for measuring the presence and/or concentration of nitric oxide in a sample.
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
74.
HIGH STRENGTH COMPOSITE MATERIALS AND RELATED PROCESSES
Composite materials exhibiting very high strength properties and other characteristics are disclosed. The materials comprise one or more nanomaterials dispersed within one or more matrix materials. The nanomaterials can be in a variety of forms, such as for example, carbon nanotubes and/or nanofibers. The matrix material can be glass, fused silicas, or metal. Also disclosed are various processes and operations to readily disperse and uniformly align the nanotubes and/or nanofibers in the flowing matrix material, during production of the composite materials.
C03C 14/00 - Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
C23C 26/02 - Coating not provided for in groups applying molten material to the substrate
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
75.
CONTROL OF MALIGNANT CELLS PROLIFERATION THROUGH THE INHIBITION OF CASEIN KINASE 2
Methods and related compositions are disclosed for treating an array of myeloproliferative disorders and hematological malignancies. In particular, treatment methods and compositions for treating chronic myelogenous leukemia are disclosed. The methods and compositions utilize certain casein kinases, and specifically CK2α agents.
A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar- insertion hole, a membrane cassette, and a reservoir well.
[0398] Controller scaling and parameterization are. described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also apply to state feedback and state observer based controllers, as well as linear active disturbance rejection (ADRC) controllers. Parameterization simplifies the use of ADRC. A discrete extended state observer (DESO) and a generalized extended state observer (GESO) are described. They improve the performance of the ESO and therefore ADRC. A tracking control algorithm is also described that improves the performance of the ADRC controller. A general algorithm is described for applying ADRC to multi-input multi-output systems. Several specific applications of the control systems and processes are disclosed.
B65H 23/18 - Registering, tensioning, smoothing, or guiding webs longitudinally by controlling or regulating the web-advancing mechanism, e.g. mechanism acting on the running web
B65H 59/38 - Adjusting or controlling tension in filamentary material, e.g. for preventing snarlingApplications of tension indicators by regulating speed of driving mechanism of unwinding, paying-out, forwarding, winding, or depositing devices, e.g. automatically in response to variations in tension
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
G05B 19/416 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control of velocity, acceleration or deceleration
G05D 13/62 - Control of linear speedControl of angular speedControl of acceleration or deceleration, e.g. of a prime mover characterised by the use of electric means, e.g. use of a tachometric dynamo, use of a transducer converting an electric value into a displacement
H04L 12/16 - Arrangements for providing special services to substations
