A disadvantage of coated-type microneedles is that it is difficult to coat the microneedles with a large amount of a drug, thus limiting effective use of the drug. The present invention overcomes this disadvantage of coated-type microneedles. Provided is a drug coated-type microneedle array characterized by comprising a substrate and a plurality of microneedles, wherein groups of three or more microneedles are formed to form spaces, and each space is disposed on the substrate so as to provide a drug-coated section.
Provided is a skin external agent composition containing taurine as crystals, which has smooth feel without any skin contact. A skin external agent composition containing fine needle-like or columnar crystals of taurine having a thickness of less than 150 micrometers and a length of less than 3000 micrometers, a method for producing fine needle-like or columnar crystals of taurine, the method including a step of growing crystals in an environment in which an aqueous solution in which taurine is dissolved is mixed with or brought into contact with a liquid substance having low solubility of taurine, and a method for producing a skin external agent composition, the method including the step of growing crystals and a step of blending the fine needle-like or columnar crystals of taurine obtained in the step of growing crystals into the skin external agent composition.
To provide a practical microneedle preparation through finding an appropriate application condition regarding a geometric shape and a position on a needle of an applied material in a coated type microneedle. A microneedle array having a needle length of 350 μm or more and 1,500 μm or less and a diameter of a needle tip section apex of 15 μm or more and 100 μm or less, having a drug-applied portion, and comprising a non-biosoluble substance, preferably a non-biosoluble polymer, as a base, wherein no drug is applied to the needle tip section apex. It is preferable that the upper end of the drug-applied portion is a position 30 μm or more lower than the needle tip section apex. The maximum diameter of the drug-applied portion is preferably 300 μm or less.
Provided is a microneedle array having high bioavailability and pharmacological availability. A microneedle array including a needle portion and a substrate portion, in which the needle portion contains a valuable material in a base containing a water-soluble polymer as a main component, the substrate portion does not contain the valuable material, and the base of the substrate portion contains a water-insoluble polymer as a main component.
The present invention provides a means for shortening the onset time of action of a local anesthetic drug, an antihistamine drug, or the like on oral mucosa. This microprotrusion patch comprises a substrate and microprotrusions densely standing on the substrate, and is composed of a water-insoluble thermoplastic polymer material and is applied to an oral mucosa. This localized application system for shortening the drug action time on an oral mucosa comprises: the microprotrusion patch; a coating drug (a gel or ointment containing a medication or the like); and an adhesive tape for backing.
A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Provided is a novel means for delivering a useful ingredient into the skin. Specifically provided are: a skin external preparation composition characterized by containing composite fine needle-like crystals having a configuration such that a polymeric useful ingredient is included in crystals of a biosoluble substance; and a method for producing composite fine needle-like taurine crystals each having a polymeric useful ingredient included therein, the method being characterized by comprising a step for making crystals to grow under an environment where an aqueous solution (A) in which taurine, that is a biosoluble substance, is dissolved is mixed with or brought into contact with a liquid substance (B) having poor taurine solubility, wherein the polymeric useful ingredient is dissolved or dispersed in the aqueous solution (A) or the liquid substance (B), whereby the polymeric useful ingredient is included in the crystals as the crystals grow.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
Provided are a means for crystallizing a valuable substance that is unstable in an aqueous solution state and stably dispersing the substance in an oily medium, an aqueous medium, or an emulsified medium in which the oily medium and the aqueous medium are mixed, and to a composition for application to skin with which a crystallized s absorbed through the skin. A skin care composition for application to skin, including a valuable substance that is dispersed in a crystalline state, and a method for producing a skin care composition for application to skin, the method including a step of preparing a solution of a valuable substance at a supersaturation concentration, adding the solution to a composition for application to skin, and precipitating crystals while stirring under cooling.
A new means of intradermal delivery of a useful component is provided. Disclosed are an external-use skin preparation composition comprising fine needlelike taurine crystals including a useful component in the crystals, and a method for producing a fine needlelike taurine crystal including a useful component in the crystal, the method comprising a step of growing a crystal in an environment in which an aqueous solution (A) containing taurine dissolved is mixed with or held in contact with a liquid substance (B) having low solubility of taurine, wherein the useful component is dissolved or dispersed in the aqueous solution (A) or the liquid substance (B), whereby the useful component is included in the crystal along with the growth of the crystal.
A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61K 8/58 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Provided are: a high-quality microneedle preparation containing collagen as a main component; and a method for producing the microneedle preparation. Provided are: the microneedle preparation which contains collagen and one or a plurality of pH modifiers as essential components; the microneedle preparation which further contains one or a plurality of carboxyl-group-containing water-soluble polymers as essential components; and the method for producing a microneedle preparation, the method comprising a step for preparing an aqueous solution at 37°C or lower using a raw material containing collagen and one or a plurality of pH modifiers and optionally further containing one or a plurality of carboxyl-group-containing water-soluble polymer to provide a microneedle raw material solution in which the content of collagen in the aqueous solution is 5% by mass or less, and a step for filling the microneedle raw material solution in a mold and then drying the microneedle raw material solution.
The purpose of the present invention is to provide a means for shortening the time of development of the action of a local anesthetic agent, an antihistamine drug or the like against skin and oral mucosa. Provided are: a minute projection patch which is intended to be applied to skin or oral mucosa and comprises a substrate and minute projections stereoscopically erected on the substrate, in which each of the substate and the minutes projections is formed from a water-insoluble thermoplastic polymer substance having an elastic modulus of 1.5×104kgf/cm2 or less; and a local application system for shortening the time of action of a drug against skin or oral mucosa, which comprises the minute projection patch and a liniment (a gel, an ointment or the like containing a drug).
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61P 25/04 - Centrally acting analgesics, e.g. opioids
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61P 29/02 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
The purpose of the present invention is to provide an improved electrode system that can measure a glucose level or concentration in a body fluid and can be utilized in vitro or in vivo. Provided is a glucose sensor having such a structure that a working electrode part, a counter electrode part and a reference electrode part and an electric signal lead-out wire from these electrode parts are provided on the surface of a substrate on which microneedles of a microneedle patch including the substrate and microneedles made from a non-electroconductive material bristle, in which each of the electrode parts is an immobilized enzyme sensor coated by a crosslinked glucose oxidase and detects an electric signal generated in vivo in accordance with the presence of glucose in a body fluid to thereby measure the concentration of glucose.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
Provided is an applicator which is equipped with a measure for alleviating pain that occurs when a microneedle formulation is applied to skin and/or a measure for improving a puncture property, and to which a microneedle formulation of normal design or with an improved puncture property is applied. The applicator includes: a piston, or a component or a mechanism equivalent thereto, that plays a direct role of administrating a microneedle patch, a microneedle array, or microneedles onto skin; a pain alleviation mechanism for the purpose of alleviating pain and/or a protrusion-shape design for the purpose of improving puncturing performance; and a mechanism/structure for assisting the administration.
Provided is a new means for delivering a useful component into the skin. This dermatological topical agent composition is characterized by containing a fine acicular crystals of taurine including a useful component in the crystals. According to the present invention, a method for producing fine acicular crystals of taurine including a useful component in the crystals is characterized by comprising a step for growing crystals in an environment in which an aqueous solution (A) in which taurine is dissolved is mixed with or brought into contact with a liquid substance (B) having a low solubility to taurine, and is characterized in that the useful component is dissolved or dispersed in the aqueous solution (A) or the liquid substance (B), and therefore, the useful component becomes included in the crystals as the crystals grow.
Provided is a cosmetic composition that is used for imparting corneum improving effect and exhibits reduced skin irritation. A microneedle type cosmetic composition containing: 30 to 100 mass % of a water-soluble or water-swellable polymer compound; and one or more types of natural moisturizing factors, wherein when the microneedle type cosmetic composition contains 100 mass % of the water-soluble or water-swellable polymer compound, the water-soluble or water-swellable polymer compound is the natural moisturizing factors; and a method for producing the microneedle type cosmetic composition, including: preparing an aqueous solution of a water-soluble or water-swellable polymer compound, and mixing the aqueous solution with one or more types of natural moisturizing factors to produce a cosmetic raw material liquid.
Provided is a skin external agent composition which contains taurine as crystals and has a smooth tactile feel without touching the skin. Provided are: a skin external agent composition characterized by containing fine needle-like or columnar crystals of taurine which have a thickness of less than 150 micrometers and a length of less than 3,000 micrometers; a method for producing fine needle-like or columnar crystals of taurine, the method comprising a step for performing crystal growth in an environment where an aqueous solution in which taurine is dissolved is mixed with or brought into contact with a liquid substance having low taurine solubility; and a method for producing a skin external agent composition, the method comprising the step for performing crystal growth and a step for blending the fine needle-like or columnar crystals of taurine obtained in the step for performing crystal growth with a skin external agent composition.
The present invention prevents electrification of a microneedle patch from a storage process through to a use process, and improves the ease of handling of the microneedle patch consistently from production to consumption. This storage container for a microneedle patch is mainly made of paper or paper composite sheets. It is preferable that the absolute value of the surface charged voltage of the paper, or the paper composite sheets is 0.6 KV or less. It is preferable that the storage container is constituted by a container body and a lid, and that the depth of a relief pattern at a contact fitting site between the container body and the lid is 0 to 2 mm.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 μm or more and 2000 μm or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.
The present invention provides: a means for crystallizing a valuable substance, which is unstable in the state of an aqueous solution, and stably dispersing the crystallized valuable substance in an oil-based medium, an aqueous medium or an emulsion medium obtained by mixing an oil-based medium and an aqueous medium; and a composition for application to the skin, the composition being used for the purpose of having a crystallized valuable substance absorbed through the skin. The present invention provides: a skin care composition for application to the skin, the skin care composition being characterized by containing a valuable substance that is dispersed therein in a crystallized form; and a method for producing a skin care composition for application to the skin, the method comprising a step in which a solution of a valuable substance having a supersaturation concentration is prepared, the solution is subsequently added to a composition for application to the skin, and the resulting mixture is stirred while being cooled, so that crystals are precipitated.
Provided is a new means for administering a valuable substance having a fat dissolving action. A microneedle preparation including at least one of a lipolytic agent, a fat dissolving agent, or a fat metabolism promoting agent, the microneedle preparation being intended for fat reduction and/or partial slenderizing and/or skin tightening, and a microneedle preparation including a microneedle array containing a water-soluble polymer as a base and one or more selected from the group consisting of a lipase, a phosphatidylcholine, and deoxycholic acid.
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
Provided is a microneedle array for ophthalmology that can be used on the eye. A microneedle array for ophthalmology that has, as a base material, at least one type of hyaluronic acid selected from the group consisting of high-molecular-weight hyaluronic acid and crosslinked hyaluronic acid.
To provide a beauty care sheet that can be realized much more easily than conventional methods in terms of a device and an effective manner for the purpose of filling groove portions formed into fine wrinkles, sagging wrinkles and the like of the skin and recovering youthful swelling of the skin. A microneedle array for skin application having a water-soluble polymer as a base and hydroxyapatite particles dispersed in the base, a beauty sheet intended to care for a groove portion of the skin, including the microneedle array for skin application, and a beauty sheet intended to care for wrinkles between eyebrows, wrinkles of nasolabial folds, or an intermammary groove, including the microneedle array for skin application. The particle size of the hydroxyapatite particles is preferably 5 μm or less.
The present invention provides a practical microneedle preparation by finding, for microneedles to be coated, suitable coating conditions with respect to the coating geometric shape and position thereof on a needle. In this microneedle array, the needle length is 350-1,500 μm inclusive, the diameter of the apex of the needle tip is 15-100 μm inclusive, and a bio-insoluble material, preferably a bio-insoluble polymer, having a drug-coated area is used as a base, the microneedle array being characterized in that the apex of the needle tip is not drug-coated. The upper end of the drug-coated area is preferably positioned at least 30 μm lower than the apex of the needle tip. The maximum diameter of the drug-coated area is preferably at most 300 μm.
Provided is a microneedle array that achieves high bioavailability and pharmacological availability. This microneedle array comprises a needle part and a substrate part. The needle part contains a valuable material in a base thereof that has a water-soluble polymer as a main component. The substrate part does not contain a valuable material, and a base of the substrate part has a non-water-soluble polymer as a main component.
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Cosmetics; art stickers for body; facial pack; beauty masks Dietary supplements for humans; adhesive tapes for medical purposes; pharmaceutical preparations for skincare
28.
MICRONEEDLE ARRAY FOR LOCAL ANESTHESIA FOR DENTAL USE
The present invention provides a microneedle preparation which can be applied to an oral cavity easily, exerts an anesthetic effect suitable for a site of application, and has excellent stability. Provided is a quick-acting local anesthetic preparation for dental use, which comprises a microneedle array containing ethyl aminobenzoate, in which the content of ethyl aminobenzoate in the microneedle array is 5 to 30% by mass, ethyl aminobenzoate and polyvinylpyrrolidone coexist in the microneedle array, and ethyl aminobenzoate is dissolved or is uniformly dispersed in the microneedle array.
Provided is a transdermal preparation that stably retains a drug in a plaster in an amount sufficient for expressing an anticipated drug effect, and that reduces irritation of the skin to the greatest extent possible. The present invention is a transdermal preparation obtained by including a drug and a stabilizer in a base, wherein the stabilizer is selected from the group consisting of thiosulfates, sulfites, bisulfites, and nitrites. The transdermal preparation preferably furthermore includes glycerin.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61P 25/04 - Centrally acting analgesics, e.g. opioids
The present invention solves a problem that it is difficult for a microneedle located in a central portion of a microneedle array to be inserted into a skin. A microneedle array including a substrate and a plurality of microneedles arranged vertically and horizontally on one face of the substrate, wherein a needle interval of the microneedles is different in a peripheral portion and in a central portion of the substrate, and a needle density of the microneedles is different in the peripheral portion and in the central portion of the substrate. It is preferable that the needle density of the microneedles is sparser in the central portion than in the peripheral portion of the substrate, and the needle interval of the microneedles is wider in the central portion than in the peripheral portion of the substrate.
Rapid dermal administration of a skin valuable material with a microneedle array. A microneedle array containing a low molecular weight component of a water-soluble polymer and a skin valuable material as essential components. The low molecular weight component of the water-soluble polymer preferably has a molecular weight of 100,000 or less and 2,000 or more, or an aqueous solution of 5 mass % of the low molecular weight component preferably has a viscosity (20° C.) of 6 dPa·S or less.
Provided is a further stable method of moisture supply from an applicator having a nozzle attached thereto and configured to supply moisture from the back surface of a water-soluble sheet-like formulation. A nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface being smooth excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; a nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface having an uneven portion excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; and an applicator of a water-soluble sheet-like formulation, the applicator including a liquid container and the nozzle for hold and dissolution of a water-soluble sheet-like formulation.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics; cosmetic patches; sheet-shaped cosmetics; beauty
masks; facial beauty masks; facial cleansing foams; beauty
serums; creamy beauty serums; soaps and detergents;
perfumery; fragrances and incense; polishing paper;
polishing abrasive cloth; false nails; false eyelashes. Patches as pharmaceutical preparations; cosmetics for
medical use; pharmaceutical preparations; transdermal
patches for medical use; adhesive sheets for medical use. Patches as medical apparatus and instruments with
micro-needles arranged thereon; needles for medical
purposes; medical apparatus and instruments and their parts
and fittings.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics; cosmetic patches; sheet-shaped cosmetics; beauty
masks; facial beauty masks; facial cleansing foams; beauty
serums; creamy beauty serums; soaps and detergents;
perfumery; fragrances and incense; polishing paper;
polishing abrasive cloth; false nails; false eyelashes. Patches as pharmaceutical preparations; cosmetics for
medical use; pharmaceutical preparations; transdermal
patches for medical use; adhesive sheets for medical use. Patches as medical apparatus and instruments with
micro-needles arranged thereon; needles for medical
purposes; medical apparatus and instruments and their parts
and fittings.
To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan.
A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 31/737 - Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
Provided is a novel means for administering a valuable substance having a fat-dissolving effect. Provided is a tape preparation, a patch preparation, or a poultice preparation that includes any one or more of a fat-decomposing agent, a fat-dissolving agent, or a fat metabolism-promoting agent and that is for fat reduction and/or partial slimming and/or skin tightening.
A61Q 19/06 - Preparations for care of the skin for countering cellulitis
A61L 15/20 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
A61L 15/24 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics for medical use; patch-shaped pharmaceutical
preparations; sheet-shaped pharmaceutical preparations;
pharmaceutical preparations. Medical apparatus and instruments; patch-shaped medical
apparatus and instruments; sheet-shaped medical apparatus
and instruments.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Cosmetics; cosmetic patches; sheet-shaped cosmetics; beauty masks; facial beauty masks; facial cleansing foams; beauty serums; creamy beauty serums; perfumery; fragrances and incense; polishing paper; polishing abrasive cloth; false nails; false eyelashes.
(2) Patches as pharmaceutical preparations, in the nature of transdermal patches for stimulating hair growth; cosmetics for medical use, namely, medicated cosmetics for the treatment of scars and wrinkles; patch-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; adhesive sheets for medical use, namely patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders, for stimulating hair growth, for treating facial wrinkles and the treatment of damaged skin and for use in the treatment of skin disorders.
(3) Patches as medical apparatus, namely, transdermal drug delivery patches sold without medication; needles for medical purposes; medical apparatus and instruments, namely, silicone gel sheeting for the treatment of skin.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics; cosmetic patches, namely, non-medicated cosmetic patches containing anti-aging ingredients for skin care and cosmetic patches containing non-medicated skin care preparations; sheet shaped facial cosmetics, namely, facial sheet masks for cosmetic use; beauty masks; facial beauty masks; skin cleansing foams; beauty serums; creamy beauty serums Cosmetics for medical use, namely, medicated cosmetics; patch-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth ; patch-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics ; patch-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth; sheet-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics ; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders Patches as medical apparatus, namely, transdermal drug delivery patches sold without medication; needles for medical purposes; medical apparatus and instruments, namely, silicone gel sheeting for the treatment of skins
Provided is a novel means for administering a valuable substance having a fat-dissolving effect. A microneedle preparation containing any one or more of a lipolysis agent, a fat-dissolving agent, or a fat metabolism promoter, for the purpose of fat reduction and/or partial slimming and/or skin tightening; and a microneedle preparation comprising a microneedle array having a water-soluble polymer as a base thereof and containing one or more selected from the group consisting of lipase, phosphatidyl choline, and deoxycholic acid.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
Provided is a micro-needle array of which all the fine needles can be more easily inserted into the skin regardless of the positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array comprises a substrate and a plurality of micro-needles disposed on one surface of the substrate, wherein the tip sections of the plurality of the micro-needles have height differences, and the needle lengths are 80-2,000 μm inclusive. It is desirable that the height differences of the plurality of micro-needles be based on the protrusions and recesses of the substrate.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics for medical use, namely, medicated cosmetics; patch-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth; patch-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics; patch-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth; sheet-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders Medical apparatus and instruments, namely, injection needles; patch-shaped medical apparatus and instruments, namely, transdermal drug delivery patches sold without medication; sheet-shaped medical apparatus and instruments, namely, silicone gel sheeting for the treatment of wrinkles
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Cosmetics for medical use, namely, medicated cosmetics for the treatment of scars and wrinkles; patch-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth; patch-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics; patch-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for stimulating hair growth; sheet-shaped pharmaceutical preparations in the nature of transdermal patches featuring topical anesthetics; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and the treatment of damaged skin; sheet-shaped pharmaceutical preparations in the nature of transdermal patches for use in the treatment of skin disorders.
(2) Medical apparatus and instruments, namely, injection needles; patch-shaped medical apparatus and instruments, namely, transdermal drug delivery patches sold without medication; sheet-shaped medical apparatus and instruments, namely, silicone gel sheeting for the treatment of wrinkles.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Cosmetics; cosmetic patches; sheet-shaped cosmetics; beauty masks; facial beauty masks; facial cleansing foams; beauty serums; creamy beauty serums; perfumery; fragrances and incense; polishing paper; polishing abrasive cloth; false nails; false eyelashes.
(2) Patches as pharmaceutical preparations, namely, patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in hair restoration; transdermal patches that facilitate the delivery of anaesthetic; patch-shaped pharmaceutical preparations in the nature of transdermal patches for use in dermatology, namely dermatitis, skin pigmentation diseases and acne; patch-shaped pharmaceutical preparations in the nature of transdermal patches that facilitate the delivery of pharmaceutical preparations; adhesive sheets for medical use, namely, adhesive bandages.
(3) Patches as medical apparatus, namely, transdermal therapeutic patches with micro-needles arranged thereon, namely, silicone gel sheeting for the treatment of skin; needles for medical purposes; medical apparatus and instruments, namely, injection needles, and structural replacement parts and fittings therefor.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Cosmetics; cosmetic patches, namely, non-medicated cosmetic patches containing anti-aging ingredients for skin care and cosmetic patches containing non-medicated skin care preparations; sheet-shaped facial cosmetics, namely, facial sheet masks for cosmetic use; beauty masks; facial beauty masks; skin cleansing foams; beauty serums; creamy beauty serums Patches as pharmaceutical preparations, namely, patch-shaped pharmaceutical preparations in the nature of transdermal patches for treating facial wrinkles and for the treatment of damaged skin and tissue; adhesive sheets for medical use, namely, adhesive bandages Patches as medical apparatus, namely, transdermal drug delivery patches sold without medication and transdermal drug delivery patches with micro-needles arranged thereon, sold without medication; needles for medical purposes; medical apparatus and instruments, namely, injection needles and their structural replacement parts and fittings
Provided is an adhesive sheet for skin, which has a satisfactory adhesion force, and in which a drug can be stably dissolved or uniformly dispersed, and which is produced using an acrylic copolymer having excellent solubility in a hydrophilic medium. The adhesive sheet for skin includes an adhesive layer comprising an acrylic resin having "hardness" of 2.0 or less and/or having "an IR intensity ratio" of 2.0 or more. The "hardness" refers to a value (unit: N) of a compressive stress at a depth of compression of 0.1 to 0.2 mm in a (compressive stress)-to-(depth of compression) curve, in which the (compressive stress)-to-(depth of compression) curve is produced by producing a sheet having a thickness of 3 mm from an acrylic resin and then compressing a stainless cylinder having a diameter of 1.5 mm from the upper surface of the sheet at a compression rate of 0.5 mm/min using a compact tabletop tester "EZ Test EZSX" (Shimadzu Corporation).
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
The purpose of the present invention is quick dermal injection of a dermatologically valuable substance by a microneedle array. This microneedle array is characterized by having a low-molecular-weight, water-soluble polymer component and a dermatologically valuable substance as essential constituents. Preferably, the low-molecular-weight, water-soluble polymer component has a molecular weight of at most 100,000 and at least 2000, or, the viscosity (20°C) of a 5 mass% aqueous solution of the low-molecular-weight component is less than or equal to 6 dPa•S.
Provided is a cosmetic gel sheet suited for the beauty field and the medical field. This cosmetic gel sheet comprises a gel sheet comprising a water-soluble carboxylated polymer, a polyhydric alcohol, and an acid as essential constituent ingredients and wafer paper superposed as a support on one or both surfaces of the gel sheet. Carboxylated polysaccharides are suitable for use as the water-soluble carboxylated polymer. The gel sheet has a water content of 30 wt% or less, and the water content thereof is more preferably 20 wt% or less. In this cosmetic gel sheet, the gel sheet can be produced by drying an aqueous solution containing a water-soluble carboxylated polymer, a polyhydric alcohol, and an acid as essential ingredients. When doing so, it is desirable that the acid content in the aqueous solution is suitable for making the aqueous solution have a pH of 2.0-4.5.
Provided is a cosmetic composition by which skin irritation for a dead skin ameliorating effect is relieved. Provided are: a microneedle-type cosmetic composition containing 30-100% by mass of a water-soluble or water-swellable polymer compound and one or more natural moisturizing factors (where, when the composition contains 100% of a water-soluble or water-swellable polymer compound, the water-soluble or water-swellable polymer is a natural moisturizing factor); and a method which is for producing the microneedle-type cosmetic composition, and includes a step for preparing an aqueous solution of the water-soluble or water-swellable polymer compound and mixing one or more natural moisturizing factors with the aqueous solution to produce a raw material liquid for cosmetics.
The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles.
The drug-holding microneedle array comprises: a microneedle array having a microneedle substrate 4 and microneedles, the microneedles being positioned in plural on the microneedle substrate 4 and a tip portion 1 of the microneedles projecting via steps 2; and a drug held on the tip portion of the microneedles and the steps 2.
To provide a means which makes it possible to hold a microneedle array without an adhesive sheet and protect tips of microneedles.
A foam support sheet for a microneedle array, which has an open cell surface on at least one side, the open cell surface being an arrangement portion for the microneedle array holding the microneedle array with a microneedle side of the microneedle array facing downward; as well as a microneedle array sheet consisting of a microneedle array and a foam support sheet, the foam support sheet having an open cell surface on at least one side, and the microneedle array being arranged on the open cell surface with a microneedle side of the microneedle array facing downward.
A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided.
The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.
The present invention solves the problem in which microneedles positioned at the central section of the microneedle array are not easily inserted into the skin. This microneedle array is characterized by comprising a substrate and a plurality of microneedles disposed vertically and horizontally on one surface of the substrate, wherein the inter-needle gaps and the needle density of the microneedles are different in the peripheral section and the central section of the substrate. The needle density of the microneedles is preferably sparse in the central section compared to that in the peripheral section of the substrate, and the inter-needle gaps of the microneedles are preferably greater in the central section than those in the peripheral section of the substrate.
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation which is composed of a liquid container and the nozzle.
Provided is a stabler means for supplying moisture from a nozzle mounted applicator that supplies moisture from a rear face of a water-soluble sheet-like formulation. The present invention provides: a nozzle for holding and dissolving a water-soluble sheet-like formulation, comprising a nozzle which has at least one hole in a distal end having a flat surface large enough to hold a water-soluble sheet-like formulation, the flat surface excluding the hole being smooth, and a ring-like foam which is disposed around the periphery of the distal end of the nozzle; a nozzle for holding and dissolving a water-soluble sheet-like formulation, comprising a nozzle which has at least one hole in a distal end having a flat surface large enough to hold a water-soluble sheet-like formulation, the flat surface excluding the hole having an uneven portion, and a ring-like foam which is disposed around the periphery of the distal end of the nozzle; and a water-soluble sheet-like formulation applicator that comprises a liquid container and the nozzle for holding and dissolving a water-soluble sheet-like formulation.
Provided is a topical skin application sheet having high affinity for the skin and having an excellent occlusive dressing therapy (ODT) effect and excellent stretchability. Provided are: a laminated adhesive sheet for skin that comprises, laminated in order therein, a skin adhesion layer, a protective adhesive layer, and a highly stretchable support body; and a laminated adhesive sheet for skin that comprises, laminated in order therein, a skin adhesion layer, an intermediate layer, a protective adhesive layer, and a highly stretchable support body.
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Because the needle tips do not come out of the tube in a conventional BCG vaccine tube needle, strength and technique were necessary and it was difficult to easily, evenly and reliably insert needles and perform a vaccination, which resulted in the problems that it was not possible to achieve the sufficient number of needle marks that shows the inoculation effect and that the child being vaccinated experienced pain and distress. These problems are solved by adopting a microneedle patch case of a thermoplastic plastic as the BCG vaccination tube needle, and setting the needle length to 0.2-1.0 mm.
The invention overcomes the problem that, when the tip of a micro needle is immersed in an aqueous drug solution to coat the tip of the micro needle with the drug, the aqueous drug solution rises due to capillary action, and so quantitative drug loading is extremely difficult. The invention provides a water-repellent-coated micro needle and a micro needle array comprising a drug coat layer at the tip portion of the micro needles. The invention also provides a production method for the micro needle array containing the drug coat layer at the tip portions, comprising: a step of using a template to form the micro needle array; a step of coating the micro needles of the formed micro needle array with a water-repellent; and a step of immersing the tips of the water-repellent-coated micro needles into an aqueous drug solution so as to hold the drug.
To suppress the work cost for the washing of the microneedle and the application of the medicament.
A microneedle patch storage tool according to one aspect of the present invention is a microneedle patch storage tool for storing a microneedle patch and comprises a plurality of pallets stacked in a vertical direction, and the two pallets adjacent in the vertical direction constitute one or a plurality of patch holding parts for holding the microneedle patch, and the patch holding part comprises a plurality of lower protrusions arranged in circumferentially divided manner so as to sandwich a peripheral edge part of the microneedle patch in the vertical direction and supporting the peripheral edge part of the microneedle patch from a lower side and a plurality of upper protrusions arranged in circumferentially divided manner and pressing the peripheral edge part of the microneedle patch from an upper side and is opened to at least one of upper and lower directions.
Through progress in micro-machining technologies, the present invention provides an auxiliary tool with which a micro-needle array, on which a plurality of micro-needles are mounted, is more reliably injected into the skin. This skin tight-binding device is provided with a tight-binding band, and a hole formed in the tight-binding band, wherein the hole forms a micro-needle patch injecting part when the tight-binding band is fixed to the skin, and the skin tight-binding device is further provided with a fixing tool for fixing the tight-binding band to the skin.
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided.
The cosmetic alcogel sheet of the present invention comprises: a water-soluble nonwoven fabric or a water-soluble film; and an alcogel which is laminated on it and contains carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components, and the sheet is characterized in that the water content of the gel is 30% by mass or less. It is more preferred that the carboxy group-containing water-soluble polymer is carboxy group-containing polysaccharides, and the polyalcohol is glycerin. The cosmetic alcogel sheet of the present invention can be manufactured by: drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components on a releasable sheet to manufacture gel, and then laminating the gel on a water-soluble nonwoven fabric or a water-soluble film.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
Provided is a microneedle array that is easily applied to the oral cavity and can exhibit an anesthetic effect suited to the application site. Provided are: a fast-acting dental local anesthetic preparation which comprises a microneedle array containing a local anesthetic and has needle parts that dissolve within the mucosa when adhered to the oral mucosa or the gingiva; a microneedle array; and a microneedle patch comprising the microneedle array and a support body provided on the back face of the microneedle array. The microneedle array has microneedles, each having a height of 50 to 300 µm and a tip that is a circle with a diameter of 1 to 50 µm or a plane with the same area as the circle, and a backing with a thickness of 5 to 100 µm.
Providing a patch case that is easily attached to a microneedle applicator, easily separable from the microneedle patch upon insertion and disposable for use.
The main feature
of the patch case according to the present invention is characterized in that it is made of a thermoplastic polymer and is capable of holding a microneedle patch comprising a support film which can be heat-sealed with the thermoplastic polymer.
Preferably, the thermoplastic polymer of the body and the fusible material of the support film are both polyolefins or both are the same thermoplastic polymer. In addition, if the patch case is attached to the front of the applicator, sanitary situation can be maintained even with continuous use of the applicator, since the applicator does not contact the skin of the recipient.
[Problem] To provide a composition that lightens and plumps lips more effectively and in a simpler manner. [Solution] This microneedle array is applied locally to lips in order to lighten and/or plump the lips. The microneedle array includes a water-soluble polymer, and has a height of 50–300 µm. The tips of the microneedles are round with a diameter of 5–150 µm, or are flat surfaces with an equivalent area.
To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient.
The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass %, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass %, a surfactant is 0.05 to 5 mass %, and a water-soluble polyalcohol is 10 mass % or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Provided is a means with which it is possible to hold a microneedle array without an adhesive sheet and to protect the tips of the microneedles. A foam support sheet for a microneedle array includes an open bubble surface on at least one surface thereof, and the top of the open bubble surface is an arrangement section for the microneedle array where the microneedle side of the microneedle array is held downward. A microneedle array sheet is composed of the microneedle array and the foam support sheet, the foam support sheet including the open bubble surface on at least one surface thereof, and the microneedle side of the microneedle array being disposed downward on the top of the open bubble surface.
Provided is a means for enabling application of a water-soluble cosmetic sheet such as a microneedle array even without an adhesive sheet. A water-soluble sheet-like cosmetic product comprises: a re-peelable microneedle patch supporting body film which has a pattern coated adhesive surface on one surface thereof and which is in contact with a rear surface of a microneedle array substrate, with the adhesive surface interposed therebetween; a re-peelable water-soluble cosmetic sheet supporting body film which has a pattern coated adhesive surface on one surface thereof and which is in contact with a rear surface of a cosmetic sheet containing a water-soluble polymer, with the adhesive surface interposed therebetween; and a microneedle array and a supporting body film having a water-soluble polymer or a water-swelling resin as a base. The supporting body film comprises a microneedle patch which has a pattern coated adhesive surface on one surface thereof, and which is bonded to a rear surface of the microneedle array substrate, with the adhesive surface interposed therebetween, a water-soluble cosmetic sheet containing a water-soluble polymer, and a supporting body film. The supporting body film has a pattern coated adhesive surface on one surface thereof, and is bonded to a rear surface of the water-soluble cosmetic sheet with the adhesive surface interposed therebetween.
The present invention provides a means with which the administration of a water-soluble sheet-shaped preparation to skin at various areas can be ensured, and moisture can be supplied from a rear surface of the water-soluble sheet-shaped preparation. Provided are: a nozzle having at least one hole provided in a tip portion which has a plane of a size capable of holding the water-soluble sheet-shaped preparation, and having recess-and-protrusion portions on the plane excluding the hole; and an applicator for a water-soluble sheet-shaped preparation, the applicator comprising a liquid container and said nozzle.
Provided is a novel percutaneous absorption type patch containing rotigotine. A percutaneous absorption type patch which comprises a support, a drug-containing layer and a release liner, wherein the drug-containing layer contains rotigotine, a polyisobutylene based adhesive, liquid paraffin and polyvinylpyrrolidone; and the percutaneous absorption type patch, wherein said drug-containing layer further contains an acrylic adhesive.
Provided is a microneedle patch applicator with which a microneedle patch can be easily fitted, and with which there is no risk of skin infection even if administered consecutively to multiple users. This microneedle patch applying device is provided with: a movable cylinder one end of which has an opening portion provided with a catch or a screw for fitting a microneedle patch case; a case body linked to the other end of the movable cylinder; a piston disposed movably in the direction of the opening portion of the movable cylinder, inside the case body; a slide which causes the piston to slide in the opposite direction to the direction of the opening portion; a slide lock which locks the sliding of the slide in said opposite direction; a spring which applies an impact to the piston by means of the sliding in said opposite direction and the locking thereof; a safety shaft which prevents release of the slide lock; and a trigger which is interlocked with the safety shaft. The distal end microneedle patch case is pressed against the skin, but is replaced for each application.
Provided is a practical microneedle preparation which solves the problem that even if it is possible for a drug to be applied quantitatively onto a tip end portion of a microneedle, a drug residue is generated on the stratum corneum when the drug is actually used as a percutaneous absorption medication. In a microneedle array in which a needle length is at least equal to 350 μm and at most equal to 900 μm, the diameter of the apex of the needle tip end portion is at least equal to 20 μm and at most equal to 100 μm, which has a drug coat coating portion, and which has a bio-insoluble polymer as a base, a lower edge of the drug coating portion is at least 200 μm from a root of the needle.
Provided are a microneedle with excellent performance and a method for manufacturing the microneedle.
A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280° C., a metal mold temperature of 60-130° C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.
Provided is a drug delivery system that is capable of shallowly puncturing the skin and surely delivering a drug. A transdermal absorption preparation comprising a solid microneedle containing a medical component, the both ends of said microneedle being in a needle-like shape with an acute angle; and a drug, in particular, a vaccine preparation for animals comprising a solid microneedle containing an antigen component of a pathogen, the both ends of said microneedle being in a needle-like shape with an acute angle.
Provided is a gel sheet for cosmetic use, which is suitable for use in the fields of cosmetic and medicine. An alcogel sheet for cosmetic use according to the present invention is characterized by comprising a water-soluble non-woven fabric or a water-soluble film and an alcogel that is laminated on the water-soluble non-woven fabric or the water-soluble film and contains a carboxy-group-containing water-soluble polymer, a polyhydric alcohol and an acid as the essential components, wherein the gel has a water content of 30% by mass or less. It is more preferred that the carboxy-group-containing water-soluble polymer is a carboxy-group-containing polysaccharide and the polyhydric alcohol is glycerin. The alcogel sheet for cosmetic use according to the present invention can be produced by drying an aqueous solution containing a carboxy-group-containing water-soluble polymer, a polyhydric alcohol and an acid as the essential components on a mold-release sheet to produce a gel and then laminating the gel on a water-soluble non-woven fabric or a water-soluble film.
Provided is a means for exhibiting an excellent fucoidan effect by developing a new method for administering a fucoidan-containing hair growth agent. This hair growth agent is characterized by being formed from a combination of a fucoidan-containing microneedle, and a fucoidan-containing ointment. The base of the fucoidan-containing microneedle is preferably a biosoluble polymer. This hair growth method is characterized by the combined use of a fucoidan-containing microneedle, and a fucoidan-containing ointment.
Provided is a patch case that can easily be attached to a microneedle applicator, enables easy separation of microneedle patches during needling, and can be used disposably. The main body of a patch case according to the present invention is characterized by having a thermoplastic polymer as a raw material and being capable of holding microneedle patches comprising a support body film that can be thermally fused with said thermoplastic polymer. It is preferable that the thermoplastic polymer of the main body and the fusible raw material of the support body film are both polyolefins or both the same thermoplastic polymer. Since the applicator does not make contact with the skin of a person receiving administration if the patch case is attached to the front surface of the applicator, hygiene can be maintained even if the applicator is used continuously.
Provided is a composition for a coating liquid for microneedles which is optimal for when coating microneedles with a drug. This coating liquid for microneedles is an aqueous solution which has, as essential components of a base thereof, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide, and a surfactant, and is characterized in that: the proportion of the water-soluble polysaccharide in the base is 2-60 mass%; and the hardness of a coating substance after drying is at least 10 N. A water-soluble polyhydric alcohol may also be included. It is preferable that, in the base, the proportion of the monosaccharide and/or the disaccharide be 30-95 mass%, the proportion of the surfactant be 0.05-5 mass%, and the proportion of the water-soluble polyhydric alcohol be not more than 10 mass%. Hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable as the water-soluble polysaccharide.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Film-like collagen has been developed for the first time with the present invention. It has been shown that a triple helix collagen film formed of a triple helix collagen and a compatibilizer is effective for removing wrinkles on skin. The triple helix collagen film is formed of a triple helix collagen and a compatibilizer. The performance can be increased by adding a film-reinforcing agent and a water-soluble plasticizer. Dextran or starch can be suitably used as the compatibilizer.
The purpose of the invention is to suppress operation costs for cleaning microneedles and applying drugs to same. One aspect of this microneedle patch storing tool is a microneedle patch storing tool for storing microneedle patches, wherein the microneedle patch storing tool comprises a plurality of pallets stacked in the vertical direction. Two pallets adjacent in the vertical direction constitute one or more patch holding units that hold the microneedle patches. The patch holding unit comprises, so as to clamp the rim portion of the microneedle patches in the vertical direction: a plurality of bottom projections that are disposed separated from each other along the circumferential direction so as to hold the rim portion of the microneedle patches from the bottom; and a plurality of top projections that are disposed separated from each other along the circumferential direction so as to press the rim portion of the microneedle patch from the top. The patch holding unit is open in at least one of the upper and lower directions.
A DDS carrier that allows the sustained release of a drug, and a method for producing the same. The present invention is characterized in that a drug is held in a PEG-carboxy-group-containing polymer graft. A carboxy-group-containing polysaccharide can be used suitably among the polymers. The PEG-carboxy-group-containing polymer graft is a compound in which polyethylene glycol is grafted to a carboxy-group-containing polymer. When a carboxy-group-containing polysaccharide is used, a polymer graft can be produced by utilizing a condensation reaction between aminated PEG and a carboxy-group-containing polysaccharide in the presence of a triazine condensing agent. A PEG-carboxy-group-containing polysaccharide graft can also be produced by utilizing a condensation reaction between PEG and a carboxy-group-containing polysaccharide in the presence of an acid.
A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided.
The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
Provided are: a microneedle having excellent performance; and a method for producing the microneedle. A microneedle array which is produced using polyglycolic acid as a material, wherein the degree of crystallinity of polyglycolic acid is 21% or more, and the rate of shrinkage of a tip part of the microneedle array is 99% or more as measured in the axis direction; and a method for producing a microneedle array in which the degree of crystallinity of polyglycolic acid is 21% or more and the rate of shrinkage of a tip part of the microneedle array is 99% or more as measured in the axis direction, said method comprising carrying out the ejection molding of polyglycolic acid at a cylinder temperature of 230 to 280ºC, a mold temperature of 60 to 130ºC and an ejection pressure of 1000 to 1500 KPa.
Provided is a depilatory tape which can be adhered in intimate contact to a region of the skin to be depilated, and with which depilation is possible simply by peeling, without causing pain or injury to the skin. This depilatory tape 1 is characterized by comprising a water vapor-impermeable or relatively impermeable support 2, and a mixture 3 of a depilatory agent and an adhesive base, retained on the support 2, the depilatory agent being composed of thioglycolic acid or a salt thereof, and the adhesive base being composed of a water-soluble polymer and a polyhydric alcohol, the polyhydric alcohol content being 150-500 mass parts to 100 mass parts of the water-soluble polymer.
Provided is a urethane-based pressure-sensitive adhesive having improved pressure-sensitive adhesive properties, while maintaining the gentleness to the skin of urethane-based pressure-sensitive adhesives. This urethane-based pressure-sensitive adhesive composition contains as essential ingredients a urethane-based pressure-sensitive adhesive, a curing agent, and a hydrophilic plasticizer. The hydrophilic plasticizer is a hydrophilic, high-boiling liquid that is compatible with urethane and produces a plasticizing effect, and is preferably one having one or more hydroxyl groups or oxyethylene groups, or both, in the molecule. The solid fraction composition ratios of the urethane-based pressure-sensitive adhesive, the curing agent, and the hydrophilic plasticizer are 0.5-15 mass parts of the curing agent and 10-80 mass parts of the hydrophilic plasticizer, to 100 mass parts of the urethane-based pressure-sensitive adhesive.
The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles.
The drug-holding microneedle array comprises: a microneedle array having a microneedle substrate 4 and microneedles, the microneedles being positioned in plural on the microneedle substrate 4 and a tip portion 1 of the microneedles projecting via steps 2 and a drug held on the tip portion of the microneedles and the steps 2.
Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.
