Abstract

The current invention relates to a method for producing an alcohol-free, antimicrobial, moisturising hand sanitizer comprising (i) a polymer-based nanoemulsion including one or more active compounds selected from cyanovirin-N (CV-N), cannabidiol (CBD) and palmitic acid (PA); and (ii) an aqueous gel-like moisturizing composition comprising xanthan gum, glycerol and a preservative such as citric acid. The invention further relates to an alcohol-free, antimicrobial, moisturising hand sanitizer produced by the method of the invention, as well as to use of the hand sanitizer as an antimicrobial, in particular an antiviral agent.

IPC Classes  ?

• A61K 8/06 - Emulsions
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Abstract

The present invention provides a preparation method for biodegradable polymer nanocomposite films with superior gas barrier, tensile properties, and dimensional stability at the retort temperature utilizing a one-step-reactive compounding process to achieve improved interaction between a biodegradable polymer, which is an aliphatic-aromatic copolyester based on the monomers 1.4-butanediol, adipic acid, terephthalic acid, succinic acid, and lactic acid in the polymer chain, and nanoparticles, including layered silicate type nanoclay and Metal Organic Framework (MOF). Various biodegradable polymers, such as PBAT, PLA, PHA, PBS, PCL, and PHBV, can be used as the supportive outer layers in a nanocomposite multilayer films, providing versatility in applications. The one-step-reactive compounding method offers an economical and environmentally friendly approach for the preparation of these advanced biodegradable polymer nanocomposite films.

IPC Classes  ?

• C08J 5/18 - Manufacture of films or sheets
• B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
• B32B 27/36 - Layered products essentially comprising synthetic resin comprising polyesters
• B29C 48/10 - Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels flexible, e.g. blown foils
• B29C 48/21 - Articles comprising two or more components, e.g. co-extruded layers the components being layers the layers being joined at their surfaces
• B29C 48/405 - Intermeshing co-rotating screws
• B29C 48/49 - Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using two or more extruders to feed one die or nozzle
• B29B 9/12 - Making granules characterised by structure or composition

Abstract

The current invention relates to a polymer-lipid microemulsion delivery system for drugs or antiviral compounds used in the treatment or inhibition of viral Acute Respiratory Distress Syndromes (ARDS), a process for producing the microemulsion delivery system, and to methods of use of the microemulsion delivery system for the treatment of ARDS.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The current invention relates to a method for producing an alcohol-free, antimicrobial, moisturising hand sanitizer comprising (i) a polymer-based nanoemulsion including one or more active compounds selected from cyanovirin-N (CV-N), cannabidiol (CBD) and palmitic acid (PA); and (ii) an aqueous gel-like moisturizing composition comprising xanthan gum, glycerol and a preservative such as citric acid. The invention further relates to an alcohol-free, antimicrobial, moisturising hand sanitizer produced by the method of the invention, as well as to use of the hand sanitizer as an antimicrobial, in particular an antivirual agent.

IPC Classes  ?

• A61K 8/06 - Emulsions
• A61K 8/34 - Alcohols
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/36 - Carboxylic acidsSalts or anhydrides thereof
• A61K 8/365 - Hydroxycarboxylic acidsKetocarboxylic acids
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61K 8/73 - Polysaccharides
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61K 8/86 - Polyethers

Abstract

The current invention relates to a method for producing an alcohol-free, antimicrobial, moisturising hand sanitizer comprising (i) a polymer-based nanoemulsion including one or more active compounds selected from cyanovirin-N (CV-N), cannabidiol (CBD) and palmitic acid (PA); and (ii) an aqueous gel-like moisturizing composition comprising xanthan gum, glycerol and a preservative such as citric acid. The invention further relates to an alcohol-free, antimicrobial, moisturising hand sanitizer produced by the method of the invention, as well as to use of the hand sanitizer as an antimicrobial, in particular an antivirual agent.

IPC Classes  ?

• A61K 8/06 - Emulsions
• A61K 9/107 - Emulsions
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• A61K 8/34 - Alcohols
• A61K 8/36 - Carboxylic acidsSalts or anhydrides thereof
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61K 8/73 - Polysaccharides
• A61K 8/365 - Hydroxycarboxylic acidsKetocarboxylic acids
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/86 - Polyethers
• A61K 8/35 - Ketones, e.g. quinones, benzophenone

Abstract

NbNbNbNbVPE-1b, in a plant, including with the expression a genome editing vector for targeted mutagenesis of the cysteine protease(s). The invention further relates to a method of increasing the yield and/or quality of recombinant proteins in the plant where expression of the one or more cysteine protease(s) has been downregulated in accordance with the method of the invention.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 9/50 - Proteinases
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The application relates to a portable, battery powered instrument (10) for detecting and/or quantifying an analyte in a sample comprising a battery, a light source (16), optionally one or more light filter(s) (20) positioned above the light source (16), and a planar support (28) for a microarray slide (22), the support (28) being positioned above the light source (16), and where present, above the at least one light filter (20). The application further relates to a method for using the instrument (10) for the detection and/or quantification of an analyte in a sample.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

The current invention relates to an antiviral lotion effective against enveloped viruses, including coronaviruses comprising griffithsin (GRFT). The invention further relates to a process for producing said antiviral lotion, and to use of the antiviral lotion as an antiviral agent against enveloped viruses, including coronaviruses.

IPC Classes  ?

• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• A61K 36/04 - Rhodophycota or rhodophyta (red algae), e.g. Porphyra
• A61K 47/16 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61K 8/9717 - Rhodophycota or Rhodophyta [red algae], e.g. Porphyra

Abstract

The current invention relates to a polymer-lipid nanocomplex for enhanced aqueous solubilisation and absorption of hydrophobic active compounds, a process for producing such a nanocomplex, and to methods of use of such a nanocomplex.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/107 - Emulsions
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/05 - Phenols
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Abstract

The present invention relates to one or more one or more non-surfactant biodegradable polymer compound(s) comprising one or more modified polysaccharide(s) for immobilization of viral particles and/or inhibition of a virus, wherein the modified polysaccharide(s) are hydrophobically modified polysaccharide(s) and/or are modified to have a cationic charge. The invention further relates to PPE materials and articles treated with the at least one modified non-surfactant biodegradable polymer compound(s) of the invention, and to a method of immobilization of viral particles and/or inhibition of the virus with the use of a PPE material comprising the one or more modified non-surfactant biodegradable polymer compound(s).

IPC Classes  ?

• C08B 3/10 - Preparation of cellulose esters of organic acids of monobasic organic acids with three or more carbon atoms with five or more carbon atoms
• C08B 11/02 - Alkyl or cycloalkyl ethers
• C08B 31/04 - Esters of organic acids
• C08B 31/12 - Ethers having alkyl or cycloalkyl radicals substituted by hetero atoms
• C08B 31/10 - Alkyl or cycloalkyl ethers
• C08B 37/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C08B 11/145 - Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with nitrogen-containing groups with basic nitrogen, e.g. aminoalkyl ethers
• C08B 31/08 - Ethers
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• C08L 1/10 - Esters of organic acids
• C08L 1/28 - Alkyl ethers
• C08L 3/06 - Esters
• C08L 3/08 - Ethers
• C08L 5/04 - Alginic acidDerivatives thereof
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A41D 13/11 - Protective face masks, e.g. for surgical use, or for use in foul atmospheres

Abstract

The current invention relates to a polymer-lipid microemulsion delivery system for drugs or antiviral compounds used in the treatment or inhibition of viral Acute Respiratory Distress Syndromes (ARDS), a process for producing the microemulsion delivery system, and to methods of use of the microemulsion delivery system for the treatment of ARDS.

IPC Classes  ?

• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61P 31/12 - Antivirals
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 9/51 - Nanocapsules
• A61K 9/107 - Emulsions

Abstract

The current invention relates to a polymer-lipid nanocomplex for enhanced aqueous solubilisation and absorption of hydrophobic active compounds, a process for producing such a nanocomplex, and to methods of use of such a nanocomplex.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/51 - Nanocapsules
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 47/02 - Inorganic compounds
• A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 31/05 - Phenols
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 25/22 - Anxiolytics
• A61P 25/24 - Antidepressants
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/06 - Antibacterial agents for tuberculosis
• A61P 31/10 - Antimycotics
• A61P 31/12 - Antivirals
• A61P 33/06 - Antimalarials

Abstract

The current invention relates to a polymer-lipid nanocomplex for enhanced aqueous solubilisation and absorption of hydrophobic active compounds, a process for producing such a nanocomplex, and to methods of use of such a nanocomplex.

IPC Classes  ?

• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• A61K 9/107 - Emulsions
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/51 - Nanocapsules
• A61K 31/05 - Phenols
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 25/22 - Anxiolytics
• A61P 25/24 - Antidepressants
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/06 - Antibacterial agents for tuberculosis
• A61P 31/10 - Antimycotics
• A61P 31/12 - Antivirals
• A61P 33/06 - Antimalarials

Abstract

This invention relates to a membrane and method for the preservation of agricultural produce. According to a first aspect of the invention there is provided a membrane for the preservation of agricultural produce comprising first and second outer polymeric layers, at least one of the outer polymeric layers being impregnated with a hydrophilic agent, and an inner layer dispersed in between the outer layers, the inner layer consisting of a polymer being impregnated with a carrier for incorporation of an antimicrobial volatile into the inner layer, the inner layer further including an absorptive agent, wherein in use, the membrane is placed proximate to agricultural produce to be preserved.

IPC Classes  ?

• A23B 7/16 - Coating with a protective layerCompositions or apparatus therefor
• A01N 25/34 - Shaped forms, e.g. sheets, not provided for in any other group of this main group
• A23B 7/148 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
• B32B 27/06 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance
• B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
• A01N 65/44 - Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
• A01N 25/18 - Vapour or smoke emitting compositions with delayed or sustained release
• A23B 7/152 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
• B65D 65/42 - Applications of coated or impregnated materials
• B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators

Abstract

The invention provides a method for the manufacture of amylose-lipid complexes The method includes the steps of pasting a mixture of starch and a fatty acid until after the second biphasic peak viscosity is reached, hydrolysing the starch with a hydrolysing enzyme, and dispersing the hydrolysed starch and working up of the residue. The amylose-lipid complexes has nano-structure dimensions and can be used a fat replacer in foodstuffs.

IPC Classes  ?

• A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
• A23D 7/015 - Reducing calorie contentReducing fat content
• C11C 3/00 - Fats, oils or fatty acids obtained by chemical modification of fats, oils or fatty acids, e.g. by ozonolysis

Abstract

This invention relates to a membrane and method for the preservation of agricultural produce. According to a first aspect of the invention there is provided a membrane for the preservation of agricultural produce comprising first and second outer polymeric layers, at least one of the outer polymeric layers being impregnated with a hydrophilic agent, and an inner layer dispersed in between the outer layers, the inner layer consisting of a polymer being impregnated with a carrier for incorporation of an antimicrobial volatile into the inner layer, the inner layer further including an absorptive agent, wherein in use, the membrane is placed proximate to agricultural produce to be preserved.

IPC Classes  ?

• A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
• A23B 7/144 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor
• A23B 7/148 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
• B65D 81/24 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
• B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators
• A01N 25/34 - Shaped forms, e.g. sheets, not provided for in any other group of this main group
• A01N 65/22 - Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
• A01N 65/36 - Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
• A01N 65/44 - Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass

Abstract

The present invention extends on-chip lensless microscope systems (10), including optofluidic microscope (OFMs) and holographic imaging microscopes to incorporate computational photography principles. A LF-OFM system 10 includes at least one plasmonic lens (50) with apertures (38), at least one microfluidic channel (28), and an image sensor array (24). The system (10) is capable of generating an image through computational photography.

IPC Classes  ?

• G01B 9/04 - Measuring microscopes
• G01N 33/483 - Physical analysis of biological material