Abstract

The present invention relates to a photodetector and a sensor comprising same. Specifically, according to an embodiment of the present invention, a photodetector may be provided, the photodetector comprising: a positive electrode; a negative electrode facing the positive electrode; a light absorption layer which is located between the positive electrode and the negative electrode and which includes quantum dots so that electron-hole pairs are generated by absorbing light and the generated electron-hole pairs are separated; an electron transport layer which is located between the positive electrode and the light absorption layer and which transports the electrons toward the positive electrode; and a hole transport layer which is located between the light absorption layer and the negative electrode and which transports the holes toward the negative electrode, wherein the quantum dots are heavy metal-free quantum dots in which no heavy metals are included, and the hole transport layer comprises: a first transport layer which is located between the light absorption layer and the negative electrode and which includes a hole migration resistance reducing material so that the holes are extracted from the light absorption layer; and a second transport layer which is located between the first transport layer and the negative electrode and which transports the holes extracted by the first transport layer toward the negative electrode.

IPC Classes  ?

• H10K 30/60 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation in which radiation controls flow of current through the devices, e.g. photoresistors
• H10K 30/81 - Electrodes
• H10K 30/35 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains comprising inorganic nanostructures, e.g. CdSe nanoparticles
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 30/86 - Layers having high hole mobility, e.g. hole-transporting layers or electron-blocking layers
• A61B 5/024 - Measuring pulse rate or heart rate
• H10K 77/10 - Substrates, e.g. flexible substrates

Abstract

The present invention relates to a memory management system using memory virtualization and real-time scheduling. According to the present invention, the memory management system using memory virtualization and real-time scheduling comprises: a processor unit which manages a mapping table for converting a virtual memory address allocated to each of multiple DNN operations into a GPU virtual address in which data required for executing a corresponding DNN operation is stored, and accesses the GPU virtual address through a virtual memory address for the DNN operation on the basis of the mapping table and scheduling information to read the data, or swaps out the data from a GPU memory to a CPU memory or swaps in the data from the CPU memory to the GPU memory; and a scheduling unit for providing the scheduling information to the processor unit by scheduling an execution order and a swap-in/out operation for multiple DNN operations over time.

IPC Classes  ?

• G06F 12/0888 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches using selective caching, e.g. bypass
• G06F 12/1009 - Address translation using page tables, e.g. page table structures
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

Provided are a nitrogen-doped composite having a high degree of ordering and a method for producing the same. The composite includes a carbon support and a nitrogen-doped nanoparticle supported on the carbon support, wherein the nanoparticle includes an alloy including platinum and a metal other than platinum and has a coercivity of 7 kOe or more.

IPC Classes  ?

• H01M 4/92 - Metals of platinum group
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/065 - Carbon
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

Abstract

Disclosed herein are a pharmaceutical composition comprising an inhibitor of Olfr164 for the prevention or treatment of sepsis, a method for the prevention or treatment of sepsis, a use of Olfr164 as a marker for selecting sepsis therapeutic agents, a screening method for sepsis therapeutics using same, and a transgenic animal in which Olfr164 is knocked out. The composition comprising Olfr164 inhibitor can effectively prevent or treat sepsis. Additionally, sepsis therapeutics can be effectively screened by comparing the expression level or activity of Olfr164 before and after administering the candidate substance.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates

Abstract

Disclosed are a bladder monitoring method and apparatus based on a multi-channel strain bladder sensor, and a multi-channel strain bladder sensor verification method and apparatus. The multi-channel strain bladder sensor verification method according to an embodiment of the present disclosure may comprise the steps of: controlling expansion and contraction of a measurement object acting as a bladder; acquiring a sensing value from each channel of a bladder sensor attached to the measurement object, according to the control of expansion and contraction of the measurement object; tracking the volume change and expansion direction of the measurement object by analyzing data regarding the change in the sensing value from each channel of the bladder sensor; and verifying the bladder sensor on the basis of whether the volume change and expansion direction of the measurement object are included within the standard range corresponding to the control of expansion and contraction of the measurement object.

IPC Classes  ?

• A61B 5/20 - Measuring urological functions

Abstract

The present invention relates to a thermally conductive sheet having high thermal conductivity and a manufacturing method therefor, the thermally conductive sheet being formed by dispersing a thermally conductive filler in a polymer resin of the thermally conductive sheet and then applying a low magnetic field thereto, thereby aligning the thermally conductive filler in the vertical direction or the horizontal direction of the sheet. The thermally conductive sheet of the present invention enables the alignment direction of the thermally conductive filler to be changed by adjusting the direction of the magnetic field, and thus the structure of the thermally conductive sheet can be adjusted.

IPC Classes  ?

• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
• C08K 3/04 - Carbon
• C08J 5/18 - Manufacture of films or sheets

Abstract

The present disclosure relates to an electrode for a lithium metal battery, the electrode including: a current collector; and a silica layer containing plate-like porous silica, wherein pores of the plate-like porous silica have a cylindrical structure, and a lithium metal battery including the same. The formation of lithium dendrites on a surface of a negative electrode is prevented, such that stability of the battery may be improved and long-term cycle performance and rate capability may be improved.

IPC Classes  ?

• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 10/052 - Li-accumulators

Abstract

A warmth measurement device according to an embodiment of the present invention includes: a pyroelectric element unit that generates electricity when there is a temperature gradient therein; and a temperature control unit that is connected to one side of the pyroelectric element unit and provides hot air or cold air to the pyroelectric element unit to maintain the pyroelectric element unit at a set temperature different from room temperature.

IPC Classes  ?

• G01K 7/00 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat
• G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
• H10N 10/10 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects
• H01L 29/40 - Electrodes

Abstract

One embodiment of the present invention relates to a composition for treating kidney diseases, comprising metixene or a pharmaceutically acceptable salt thereof and, more specifically, to metixene which inhibits the expression level of a gene or protein of a renal fibrosis factor.

IPC Classes  ?

• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a system for predicting a pseudo-random number initial seed, and more particularly, to a system for predicting a pseudo-random number initial seed to receive N sequence vectors for a pseudo-random number to extract a learning vector containing feature information for each of the N sequence vectors, and receive the learning vector to derive initial seed information for the pseudo-random number.

IPC Classes  ?

• G06F 7/58 - Random or pseudo-random number generators

Abstract

A magnetic driving system according to the present disclosure comprises: a bed; a first magnetic generator installed on one side of the bed; a second magnetic generator installed on the rear surface of the bed; an imaging device connected to the first and second magnetic generators; and a controller for controlling the first and second magnetic generators and the imaging device.

IPC Classes  ?

• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis

Abstract

The present invention relates to a method for preparing a lithium metal negative electrode from which a surface oxide layer is removed by physically removing the surface oxide layer formed on the surface of lithium metal by using a cutting tool, and to a lithium metal negative electrode prepared by the method. According to the present invention, since there is no surface oxide layer causing non-uniformity of the surface of the lithium metal negative electrode, overvoltage is reduced at the interface between the negative electrode and an electrolyte, thereby enabling rapid and uniform transport. It is possible to inhibit dendritic growth on the surface of the negative electrode as a nucleus is not locally formed, and a generally flat and uniform electrodeposition shape is exhibited. In addition, the number of cycles is increased, and the formation of a lithium porous layer and dead lithium, which are factors degrading the performance of a lithium metal battery, is reduced, thereby improving cycle performance.

IPC Classes  ?

• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/04 - Processes of manufacture in general
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/40 - Alloys based on alkali metals
• H01M 4/66 - Selection of materials
• B23C 3/13 - Surface milling of plates, sheets or strips
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

Memory systems and methods for operating the same. A memory system comprises a first memory, a second memory having an operating speed different from that of the first memory, a storage unit configured to store an instruction, a prefetcher configured to update prefetcher data in response to occurrence of cache hits and a processor configured to execute the instruction stored in the storage unit. When the instruction is executed, the processor is configured to generate prefetcher friendly data by filtering the prefetcher data, set a prefetcher friendly bit in a first pointer area corresponding to the first memory and a second pointer area corresponding to the second memory based on the prefetcher friendly data, and determine whether data of the first pointer area and the second pointer area are migrated, in consideration of a reference bit and the prefetcher friendly bit of the first and second pointer areas.

IPC Classes  ?

• G06F 12/0862 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with prefetch

Abstract

The present invention relates to a composition for treating, improving, or preventing Alzheimer's disease caused by ApoE4 gene mutation, the composition including Banha-Sasim-Tang as an active ingredient. The present invention relates to a composition for treating, improving, or preventing Alzheimer's disease caused by ApoE4 gene mutation, the composition including Banha-Sasim-Tang as an active ingredient. The composition including Banha-Sasim-Tang as an active ingredient of the present invention and a treatment method exhibit excellent effects of reducing amyloid beta proteins and inhibiting deposition thereof, which are specific to Alzheimer's disease caused by ApoE4 gene mutation, thereby having high applicability as a specific composition for preventing, improving, or treating Alzheimer's disease caused by ApoE4 gene mutation.

IPC Classes  ?

• A61K 36/258 - Panax (ginseng)
• A61K 36/484 - Glycyrrhiza (licorice)
• A61K 36/539 - Scutellaria (skullcap)
• A61K 36/718 - Coptis (goldthread)
• A61K 36/725 - Ziziphus, e.g. jujube
• A61K 36/8888 - Pinellia
• A61K 36/9068 - Zingiber, e.g. garden ginger
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A magnetic driving system according to the present disclosure comprises: a bed having a working space formed on one side of the upper surface thereof; a magnetic generating unit including a magnetic core and a coil wound around the magnetic core, and disposed on one side of the bed; a frame supporting one end of the magnetic generating unit; an imaging device connected to the magnetic generating unit; and a controller for controlling the magnetic generating unit and the imaging device, wherein a plurality of magnetic generating units may be radially arranged such that the other ends of the magnetic generating units face the working space.

IPC Classes  ?

• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 34/30 - Surgical robots
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A data processing system includes a host configured to execute a program for processing a given data set; and a remote processing device coupled to the host via an interface, wherein the host includes a profile control circuit configured to generate a profile corresponding to a function that is called during execution of the program; a profile database storing execution location of the function corresponding to the profile; and a policy execution circuit configured to allocate the function called during the execution of the program to the host or the remote processing device based on the execution location the profile database.

IPC Classes  ?

• G16C 20/90 - Programming languagesComputing architecturesDatabase systemsData warehousing

Abstract

The present invention relates to a polymer solid electrolyte comprising: an ion-conductive polymer; organic ionic plastic crystals containing imidazolium; and a lithium salt. The polymer solid electrolyte according to an aspect can simultaneously achieve excellent ion conductivity and electrochemical stability.

IPC Classes  ?

• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/052 - Li-accumulators
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys

Abstract

The present invention relates to a composition and a kit for diagnosing autism disorder. The composition, the kit, and a method for providing information according to the present invention can conveniently and effectively diagnose autism disorder in a small amount of blood by using multiple biomarkers in which proteins and metabolites have been combined in order to diagnose autism disorder.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The capsule structure according to various embodiments of the present invention may comprise: a body; a collection module accommodated in the body and collecting a biological material; and a magnetic body accommodated in the body, wherein the collection module includes one or more collection modules. The method of driving a capsule structure may comprise the steps of: dissolving an external protective layer of collection module 1; moving the capsule structure up to a target position; applying a first external signal to heat a heating layer of collection module 1; dissolving an internal protective layer of collection module 1; and adsorbing a biological material by a polymer layer of collection module 1, wherein the capsule structure comprises: a body; a collection module accommodated in the body and collecting a biological material; and a magnetic body accommodated in the body, wherein the collection module includes collection modules from collection module 1 to collection module n (where n is an integer greater than or equal to 2).

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

Disclosed are a bottom-up instance segmentation method and apparatus. The bottom-up instance segmentation method includes acquiring an image, identifying a boundary of each instance and a shared pixel between instances by encoding the image into a seed map and a plurality of sigma maps based on a previously trained bottom-up segmentation model, and outputting a segmented image for an object in the image based on the boundary of each instance and the shared pixel between instances.

IPC Classes  ?

• G06T 7/12 - Edge-based segmentation

Abstract

An electrode catalyst is configured such that non-noble metal particles, noble metal particles or nitride-doped noble metal particles are supported on a carbon support, wherein the carbon support has a 2D planar crystal structure or a 3D polyhedral crystal structure and is doped with nitrogen, thereby exhibiting increased catalytic activity.

IPC Classes  ?

• H01M 4/92 - Metals of platinum group
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/065 - Carbon
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

Abstract

The present invention relates to optical fiber photometry. An optical brain signal measurement device (100) according to one embodiment may comprise: a light source unit (110); an excitation filter unit (120); a first segmentation/concatenation unit (130); a second segmentation/concatenation unit (140); an emission filter unit (150); and a measurement unit (160). The optical brain signal measurement device (100) can segment or concatenate optical signals through a segmentation/concatenation unit while transmitting the signals to a brain signal measurement target through an optical fiber having directivity, and identify the wavelength range to which each of multiple signals correspond through a spectrometer to obtain multiple brain signals (multiple light sources) by using the light source directivity of the optical fiber and the spectrometer without a dichroic filter.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a pharmaceutical composition for the prevention or treatment of degenerative brain diseases, comprising selexipag or a pharmaceutically acceptable salt thereof as an active ingredient. Selexipag inhibits the expression and production of pro-inflammatory or inflammatory cytokines in brain tissue, inhibits the activity of microglia or astrocytes, inhibits NLRP3 inflammasome activity and CDK6 expression, reduces amyloid plaques, increases the expression of the amyloid beta-degrading enzyme IDE, and inhibits the hyperphosphorylation of tau protein and the expression of tau kinase, and thus can be effectively used as a novel therapeutic agent for the prevention or treatment of degenerative brain diseases, cognitive disorders, learning disabilities, or memory disorders.

IPC Classes  ?

• A61K 31/4965 - Non-condensed pyrazines
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

An electrode catalyst is configured such that non-noble metal particles, noble metal particles or nitride-doped noble metal particles are supported on a carbon support, wherein the carbon support has a 2D planar crystal structure or a 3D polyhedral crystal structure and is doped with nitrogen, thereby exhibiting increased catalytic activity.

IPC Classes  ?

• H01M 4/92 - Metals of platinum group
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/065 - Carbon
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

Abstract

Provided is a fuel cell-single cell including an anode separator, a cathode separator, an integrated gasket-membrane electrode assembly (MEA) which is disposed between the anode separator and the cathode separator and in which an ion exchange process takes place, an anode hydrogen supply channel disposed between the anode separator and the integrated gasket-membrane electrode assembly to allow hydrogen to be supplied to the anode separator therethrough, and a porous separator disposed between the cathode separator and the integrated gasket-membrane electrode assembly. The airtightness of the reaction gas, the efficiency of the ion exchange reaction, and the convenience of maintenance are improved by introducing the integrated gasket-membrane electrode assembly and the porous separator into the internal structure of the fuel cell.

IPC Classes  ?

• H01M 8/0258 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors characterised by the configuration of channels, e.g. by the flow field of the reactant or coolant
• H01M 8/0276 - Sealing means characterised by their form
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
• H01M 8/241 - Grouping of fuel cells, e.g. stacking of fuel cells with solid or matrix-supported electrolytes
• H01M 8/2457 - Grouping of fuel cells, e.g. stacking of fuel cells with both reactants being gaseous or vaporised

Abstract

The present invention relates to a humanized antibody specifically binding to a human TREM2 protein and a use thereof. The humanized antibody is prepared using a CDR grafting technology in which a complementarity determining region (CDR) corresponding to an antigen binding site of a mouse antibody variable region is transplanted into a human germline-derived sequence, thereby securing the humanized antibody specifically binding to TREM2. The obtained humanized antibody was confirmed for binding ability to an antigen and biological activity, and a chimeric antibody in the form of IgG1 was converted into the forms of IgG2 and IgG4 and produced, and confirmed for binding ability to an antigen and biological activity. With a high affinity for TREM2, the present invention can develop an antibody-based diagnosis system capable of diagnosing TREM2 as a biomarker of various Alzheimer's dementia. In addition, since existing therapeutic agents for Alzheimer's disease are mostly symptom-alleviating agents due to the temporary regulation of neurotransmitters, it is considered that the development of antibodies targeting TREM2 can lead to the development of promising new drugs having substantial therapeutic effects.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to enhancing the anticancer function of a natural killer (NK) cell through the regulation of an antioxidant mechanism and confirms that, in comparison to a conventional NK cell, anticancer activity is enhanced in an NK cell having increased antioxidant activity due to the removal of the keap 1 gene or due to having been cultured in a medium containing an antioxidant material, and can thus be useful as a composition for preventing, treating, or alleviating cancer.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

The present invention relates to a human antibody specifically binding to a human TREM2 protein, and use thereof. The human monoclonal antibody specifically binding to TREM2 has been discovered through biopanning using a human synthetic antibody phage display library, and the antigen binding ability and biological activity of the discovered antibody have been identified. The present invention has a high affinity for TREM2, and thus enables the development of an antibody-based diagnosis system capable of diagnosing TREM2 as a biomarker of various Alzheimer's dementia. In addition, since a conventional therapeutic agent for Alzheimer's disease is mostly a symptom reliever through the temporary regulation of neurotransmitters, it is considered that the development of antibodies targeting TREM2 can lead to the development of promising new drugs having substantial therapeutic effects.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention pertains to: a switching device based on spin-orbit torque; and a method for manufacturing same. A switching device based on spin-orbit torque according to an embodiment comprises: a heavy metal input terminal extending in a first direction; and an information terminal extending in a second direction perpendicular to the first direction on the heavy metal input terminal and having a ferromagnetic layer, wherein the information terminal includes a first region adjacent to the heavy metal input terminal and a second region not adjacent to the heavy metal input terminal, and magnetization reversal of the ferromagnetic layer can be controlled on the basis of a non-uniform spin Hall effect (SHE) caused by the first region and the second region.

IPC Classes  ?

• H10N 50/20 - Spin-polarised current-controlled devices
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region

Abstract

Provided is a device for conveying biological material which can transport multiple biological materials and selectively transport the biological materials without cross-contamination. The device for conveying biological material according to one aspect of the present disclosure includes: a body part including a plurality of openings formed through the rear surface thereof, and a plurality of chambers formed therein to correspond to the openings; a plurality of transport parts accommodated in the chambers to store a biological material and capable of protruding out of the body part through the openings; and a magnetic driving part configured to be moved within the body part by an external magnetic field and to selectively apply pressure to one of the plurality of transport parts.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements

Abstract

The present invention relates to a technology for performing low-light image data augmentation by converting a bright image such as a daytime situation into a low-light image such as a nighttime situation, and a low-light image data augmentation system according to an embodiment includes: a training data configuration unit for configuring training data on the basis of a first image generated in a first environment classified on the basis of illuminance and a second image generated in a second environment in low illumination compared to the first environment; an input image conversion unit for converting the first image into the second image and the second image into the first image, by receiving the first image and the second image as inputs; and a calculation unit for calculating a total loss for training a model by comparing an input image with at least one of the converted first image or the converted second image, wherein the input image conversion unit can convert the first image in the first environment into the second image in the second environment on the basis of a brightness degree (b) and a weight (w), through the model trained using the total loss.

IPC Classes  ?

• G06T 5/90 - Dynamic range modification of images or parts thereof
• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06T 5/70 - DenoisingSmoothing
• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06N 3/094 - Adversarial learning

Abstract

An embodiment of the present invention provides a substrate-processing device comprising: an outer housing that forms the exterior; an inner housing that is inserted into the interior of the outer housing to be rotated relative to the outer housing and includes a mounting unit on which an object to be processed is mounted; a sputter unit disposed in the outer housing to form a thin film on the surface of the object to be processed; and a drive unit for providing a driving force that enables the inner housing to rotate, wherein the mounting unit has recesses arranged on the outer circumferential surface of the inner housing toward the center thereof.

IPC Classes  ?

• C23C 14/34 - Sputtering
• C23C 14/50 - Substrate holders
• C23C 14/56 - Apparatus specially adapted for continuous coatingArrangements for maintaining the vacuum, e.g. vacuum locks
• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/14 - Metallic material, boron or silicon

Abstract

The present invention relates to adhesion control of a hydrogel. Even if a metal cation having weak interaction with a low-molecular-weight polymer or an anionic polymer is used, the hydrogel enables stable interaction thereof. The hydrogel achieves high mechanical strength and excellent elasticity through enhanced physical cross-linking, thereby enabling low adhesion to be maintained even if being continuously and repeatedly stretched and contracted, and has excellent compatibility with a particulate material such as sand and the like, thereby having unique tactile properties while maintaining a constant exterior, and thus can be utilized as a material suitable for various industrial applications such as medical uses, environmental purification, biomaterials and the like.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• C08L 101/12 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
• C08K 3/10 - Metal compounds

Abstract

A non-volatile memory device according to various embodiments of the present invention is characterized in that the non-volatile memory device includes a substrate, a first electrode disposed on the substrate, an insulating layer contacting the first electrode, a semiconductor layer contacting the insulating layer, and a second electrode contacting the semiconductor layer, and is driven using an asymmetrical local energy state (ALES) induced in the semiconductor layer under the condition that at least a portion of the first electrode contacts the semiconductor layer. A non-volatile memory device according to various embodiments of the present invention is characterized in that the non-volatile memory device includes a substrate, a first electrode disposed on the substrate, an insulating layer contacting the first electrode, a semiconductor layer contacting the insulating layer, and a second electrode contacting the semiconductor layer, and is driven using an asymmetrical local energy state (ALES) induced in the semiconductor layer under the condition that at least a portion of the first electrode contacts the semiconductor layer. A method of driving the non-volatile memory device in accordance with various embodiments of the present invention includes inducing an asymmetrical local energy state (ALES) generated due to instantaneous acceleration of electrons injected into the semiconductor layer, and removing the ALES from the semiconductor layer, for recovery of the semiconductor layer.

IPC Classes  ?

• H10B 63/00 - Resistance change memory devices, e.g. resistive RAM [ReRAM] devices
• G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching
• H10N 70/20 - Multistable switching devices, e.g. memristors

Abstract

An IoT device according to an embodiment encrypts IoT data using a peripheral device and transmits the IoT data to a server, and a user device requests and obtains necessary IoT data from the server, thereby achieving real-time IoT data sharing. The IoT device performs only relatively low-performance operation of attribute-based encryption to encrypt IoT data collected through a sensor and outsources the remaining high-performance operations of attribute-based encryption to the peripheral device providing external communication network connection to the IoT device to generate a final ciphertext. A user device generates an attribute bloom filter using an access policy thereof, requests and obtains IoT data encrypted according to attribute-based encryption. A cloud server receives and stores IoT data encrypted by the IoT device and the peripheral device according to attribute-based encryption and transmits IoT data retrieved using the attribute bloom filter as a query to the user device.

IPC Classes  ?

• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• H04L 9/08 - Key distribution
• H04L 9/30 - Public key, i.e. encryption algorithm being computationally infeasible to invert and users' encryption keys not requiring secrecy

Abstract

The present invention relates to a three-dimensional magnetic field measurement device comprising a plurality of modules, wherein each of the modules is configured to be extensible in x-axis, y-axis, and z-axis directions, whereby magnetic field data in a three-dimensional space can be measured in real time without moving the device, a measurement area can be easily enlarged and reduced, power efficiency can be improved, and the size and weight of the device can be reduced.

IPC Classes  ?

• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• G01R 33/10 - Plotting field distribution

Abstract

The present disclosure relates to an ultrasonic sensor and a method for operating same. More specifically, the present disclosure relates to an optical machine ultrasonic sensor, the sensitivity and dynamic area of which can be adjusted by adjusting the initial position of a membrane of a cantilever structure, and a method for controlling same.

IPC Classes  ?

• G01N 29/24 - Probes
• G01N 29/04 - Analysing solids

Abstract

The present invention relates to an apparatus and a method for diagnosing a disease on the basis of artificial intelligence, wherein a disease can be diagnosed by using blood flow signals measured by means of an optical method, the apparatus comprising: a data preprocessing unit that generates input data required for artificial intelligence-based disease diagnosis by performing frequency analysis on received blood flow signal data; and an artificial intelligence-based disease diagnosis unit that diagnoses a disease by using the input data and an artificial intelligence model, wherein the input data includes relative magnitude data in a plurality of frequency bands associated with life phenomena for blood flow vibration data generated as a result of the frequency analysis on the blood flow signal data.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

A coaxial drive module capable of controlling motion and force according to the present invention comprises: a first drive unit that provides a first drive force centered on a drive shaft, a second drive unit that is coaxially connected to the drive shaft and is linked to the first drive force or provides a second drive force different from the first drive force; and an output unit that receives and outputs the first and second drive forces, wherein the first drive force includes a linear drive force applied to the output unit and controls the position of an object output by the output unit, and the second drive unit includes an elastic drive force applied to the output unit and controls the magnitude of the force output by the output unit. According to this configuration, it is possible to control the position of an object and the magnitude of an electric power that is output by the output unit by sharing a single drive shaft, thereby providing a coaxial drive module capable of highly efficiently controlling motion and force.

IPC Classes  ?

• F16H 25/20 - Screw mechanisms
• F16H 7/02 - Gearings for conveying rotary motion by endless flexible members with beltsGearings for conveying rotary motion by endless flexible members with V-belts
• F16H 57/021 - Shaft support structures, e.g. partition walls, bearing eyes, casing walls or covers with bearings

Abstract

The present invention relates to a negative electrode pre-lithiated under dry conditions, and a manufacturing method therefor. According to one embodiment of the present invention, provided is a pre-lithiated negative electrode comprising a current collector and a negative electrode active material layer coating the current collector, the negative electrode active material layer comprising a negative electrode active material and lithium metal particles, wherein a portion of the negative electrode active material is a lithiated negative electrode active material.

IPC Classes  ?

• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1393 - Processes of manufacture of electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/04 - Processes of manufacture in general

Abstract

Provided are a composite and a membrane electrode assembly including active metal particles and sacrificial metal particles, and a fuel cell including the same. The composite according to the present invention includes active metal particles and sacrificial metal particles independently supported on a carbon support, it can suppress the deterioration of the active metal and have significantly improved durability while maintaining excellent activity of the catalyst. The membrane electrode assembly according to the present invention can have excellent catalytic activity and significantly improved durability for the same reasons as the above-described composite.

IPC Classes  ?

• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 4/92 - Metals of platinum group
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]

Abstract

Provided are a composite and a membrane electrode assembly including active metal particles and sacrificial metal particles, and a fuel cell including the same.

IPC Classes  ?

• H01M 4/90 - Selection of catalytic material
• H01M 4/92 - Metals of platinum group
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
• C25B 9/60 - Constructional parts of cells
• H01M 8/10 - Fuel cells with solid electrolytes

Abstract

Presented are an anode and a lithium battery comprising same, the anode comprising: an anode current collector; a protective layer disposed on one surface of the anode current; and an anode interlayer disposed between the anode current collector and the protective layer, wherein the protective layer contains a first polymer including a high-strength polymer and a second polymer including an ion conductive polymer, and the anode interlayer comprises a mixture of first particles containing a lithiophilic metal and second particles containing a carbon element.

IPC Classes  ?

• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/66 - Selection of materials
• H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
• H01M 10/052 - Li-accumulators
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

Provided are an anode and a lithium battery including the same. The anode includes an anode current collector and a protective layer on one surface of the anode current collector, and an anode interlayer between the anode current collector and the protective layer, wherein the protective layer includes a first polymer and a second polymer, wherein the first polymer includes a high-strength polymer, and the second polymer includes an ion-conductive polymer, and the anode interlayer includes a mixture of first particles and second particles, wherein the first particles contain a lithiophilic metal, and the second particles contain a carbon element.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 10/052 - Li-accumulators

Abstract

A processor includes a processing core configured to process each of a plurality of requests by accessing a corresponding one of a first memory and a second memory, a latency monitor configured to generate first latency information and second latency information, the first latency information comprising a first access latency to the first memory, and the second latency information comprising a second access latency to the second memory, a plurality of cache ways divided into a first partition and a second partition, and a decision engine configured to allocate each of the plurality of cache ways to one of the first partition and the second partition, based on the first latency information and the second latency information.

IPC Classes  ?

• G06F 12/0811 - Multiuser, multiprocessor or multiprocessing cache systems with multilevel cache hierarchies
• G06F 12/084 - Multiuser, multiprocessor or multiprocessing cache systems with a shared cache

Abstract

The present invention relates to a monoclonal antibody specifically binding to an MLC1 protein, and use thereof. More specifically, the present invention relates to: a monoclonal antibody specifically binding to an MLC1 protein, which is specifically expressed in astrocytes of the central nervous system, and a hybridoma cell line 37E5 that produces the antibody; and use thereof, wherein the developed antibody is expected to be effectively used as a histochemical marker in humans and model animals through immunochemical tracking of MLC1 showing highly selective expression in astrocyte end-feet.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 5/16 - Animal cells
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention pertains to a highly durable conductive fiber that retains conductivity even under repeated external stress including washing. More specifically, the present invention pertains to: a highly durable conductive fiber that does not exhibit a degradation in electrical properties even under repeated external stress and retains fiber-metal interfacial adhesion; and a method for producing same.

IPC Classes  ?

• D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
• D01F 6/62 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyesters
• D06M 11/83 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metalsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metal-generating compounds, e.g. metal carbonylsReduction of metal compounds on textiles
• D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements

Abstract

A neurotransmitter concentration measuring apparatus includes a data collecting unit configured to collect fast-scan cyclic voltammetry (FSCV) data where capacitive charging current is included in faradaic current varying depending on injection concentration for each of multiple neurotransmitters, a data processing unit configured to process the FSCV data as second-derivative-based background removal (SDBR) data in a faradaic current form where the charging current is excluded, based on a second derivative for voltage of an individual voltammogram generated for each scan by background subtraction in the FSCV data, a deep learning processing unit configured to build a deep learning model that simultaneously estimates the concentration of the multiple neurotransmitters by learning the SDBR data with a deep learning network and a measurement result providing unit configured to simultaneously provide concentration measurement results of a neurotransmitter varying depending on real-time injection for each of the multiple neurotransmitters based on the learning model.

IPC Classes  ?

• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The present invention relates to a current-to-digital converter and the current-to-digital converter according to an example embodiment includes an integrator connected to a current source that outputs input current; a quantizer connected to the integrator and configured to generate a first digital output code corresponding to alternating current (AC) in the input current; a first loop circuit formed on a delta-sigma (ΔΣ) loop that connects an input terminal of the integrator and an output terminal of the quantizer; a second loop circuit formed on a truncation-noise-shaped baseline-servo (TNS-BS) loop that connects the input terminal of the integrator and the output terminal of the quantizer and configured to generate a second digital output code corresponding to direct current (DC) in the input current; and an adder configured to generate a final digital output code by adding the first digital output code and the second digital output code.

IPC Classes  ?

• H03M 1/48 - Servo-type converters
• H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter

Abstract

The present invention relates to a successive approximation register (SAR) analog-to-digital converter and the SAR analog-to-digital converter according to an example embodiment includes an input unit including at least one SAR capacitor; a recycling integrator connected to the input unit and including k integration capacitors configured to store the respective residue information generated in an integration process performed k times, respectively, (where k denotes a positive integer of 2 or more) using a single amplifier; a comparator connected to an output terminal of the recycling integrator; and a SAR controller connected to an output terminal of the comparator and configured to generate a digital signal corresponding to output of the comparator.

IPC Classes  ?

• H03M 1/08 - Continuously compensating for, or preventing, undesired influence of physical parameters of noise

Abstract

The present invention relates to an extracellular vesicle expressing a cytokine and an antibody, a method for producing same, and a use thereof. The present invention provides a method for producing an immune cell expressing both a cytokine and an antibody on membrane surface by transforming them with a first vector encoding a cytokine and a second vector encoding an antibody, and producing their extracellular vesicle expressing both a cytokine and an antibody on the surface. The present invention provides the extracellular vesicle which induces a desired cytokine response in cells that can be targeted with a specific antibody and is safe for the human body while exhibiting excellent anticancer effects. The present invention provides a new cancer treatment means that deliver drugs or physiologically active substances to specific cancer cells by loading a drug or physiologically active substance that exhibits a therapeutic effect on cancer in the extracellular vesicle.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a composite solid electrolyte comprising zeolite and a fluorine-based lithium salt, and a lithium secondary battery using same. In the composite solid electrolyte according to the present invention, the formation of lithium dendrites is dramatically reduced by optimizing the concentration of fluorine-based lithium salt in a composite solid electrolyte containing zeolite, thus making it possible to achieve a composite solid electrolyte and a lithium secondary battery comprising same in which very good electrochemical characteristics are exhibited even after long-term charging and discharging.

IPC Classes  ?

• H01M 10/056 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes
• H01M 10/052 - Li-accumulators

Abstract

An apparatus with a neural network operation of homomorphic encrypted data includes: one or more processors configured to: generate homomorphic conjugation data of encrypted data based on the encrypted data, wherein the encrypted data corresponds to an output of each of a plurality of layers included in a neural network; and remove noise of the encrypted data based on the encrypted data and the homomorphic conjugation data.

IPC Classes  ?

• G06F 21/60 - Protecting data
• G06F 7/487 - MultiplyingDividing
• G06F 17/15 - Correlation function computation

Abstract

The present invention provides a handpiece for optical treatment. In one embodiment, the handpiece for optical treatment comprises: a cylindrical body part that can be held by a user; an ultrasonic generation part provided at one end of the body part so as to emit ultrasonic waves at a treatment area, thereby raising the temperature of the treatment area to a set temperature; a laser emission part which is provided within the body part and which emits a laser at the treatment area; and a housing which is coupled to the front end of the ultrasonic generation part, and in which a medium for transmitting the ultrasonic waves to the treatment area is accommodated, wherein the ultrasonic generation part can include a frame, which is coupled to the top of the housing and has a through hole through which the laser passes, and an ultrasonic element coupled to the frame.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61N 5/067 - Radiation therapy using light using laser light
• A61N 7/02 - Localised ultrasound hyperthermia
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61N 7/00 - Ultrasound therapy

Abstract

The present invention relates to a GFRAL-antagonistic antibody having improved affinity and a use thereof, and more particularly, the present invention relates to an anti-GFRAL antibody having improved affinity, comprising a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. The anti-GFRAL antibody having improved affinity exhibits higher binding ability to a GFRAL protein than a conventional anti-GFRAL antibody, and thus is expected to be effectively used for improving or treating cancer-related anorexia or cachexia syndrome and side effects of chemotherapy anticancer drugs.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 3/00 - Drugs for disorders of the metabolism

Abstract

The present invention relates to: a method for converting non-pluripotent cells into pluripotent cells; cells produced by the method; and uses thereof. The pluripotent cells of the present invention have low tumorigenicity while having excellent cell differentiation ability and pluripotency capable of differentiating into three germ layers, and can specifically separate pluripotent cells in the intermediate stage of reprogramming, and thus, it is possible to produce pluripotent cells having characteristics different from conventional induced pluripotent stem cells.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• C12N 5/074 - Adult stem cells

Abstract

The present invention provides an electronic brake device that may comprise: a drive unit which provides driving power for braking a disc; a power distribution unit which is connected to the drive unit and distributes the driving power into first driving power and second driving power; a first pressure unit which is connected to the power distribution unit and transmits the first driving power to the disc; a second pressure unit which is connected to the power distribution unit and transmits the second driving power to the disc; and a pressure pad which is connected to the first pressure unit and the second pressure unit and transmits brake power to the disc, wherein the power distribution unit comprises: a planetary gear unit which is connected to the drive unit; a carrier unit which is connected to the planetary gear unit and provides the first driving power to the first pressure unit; and a ring gear unit which is connected to the planetary gear unit and provides the second driving power to the second pressure unit.

IPC Classes  ?

• F16D 65/18 - Actuating mechanisms for brakesMeans for initiating operation at a predetermined position arranged in or on the brake adapted for drawing members together
• F16D 125/48 - Rotating members in mutual engagement with parallel stationary axes, e.g. spur gears
• F16D 125/50 - Rotating members in mutual engagement with parallel non-stationary axes, e.g. planetary gearing
• F16D 121/24 - Electric or magnetic using motors

Abstract

The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

IPC Classes  ?

• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

The present invention provides a pattern marker that may comprise: a body part; and a pattern part which is disposed on the surface of the body part and includes a reference sequence portion and a unique sequence portion successively arranged along a first direction, wherein the reference sequence portion comprises a plurality of first elements representing first information, and the unique sequence portion comprises a plurality of second element representing second information different from the first information.

IPC Classes  ?

• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
• G06T 7/215 - Motion-based segmentation

Abstract

Disclosed is a method for training an artificial neural network capable of precision control of a magnetic robot. A method for gradually training an artificial neural network for controlling a magnetic robot, whereby the three-dimensional position of the magnetic robot is controlled, comprises: a primary training step in which a processor trains the artificial neural network to control the three-dimensional position of the magnetic robot in simulation environments; a secondary training step in which the processor additionally trains the artificial neural network to control the two-dimensional position of the magnetic robot in real-life environments after the primary training step; a tertiary training step in which the processor additionally trains the artificial neural network to control the three-dimensional position of the magnetic robot in real-life environments after the secondary training step; and a precision training step in which the processor additionally trains the artificial neural network to control the three-dimensional position of the magnetic robot in real-life environments having a preset restricted radius after the tertiary training step.

IPC Classes  ?

• G06N 3/00 - Computing arrangements based on biological models
• G06N 3/092 - Reinforcement learning
• H01F 7/02 - Permanent magnets
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• B25J 7/00 - Micromanipulators
• B25J 9/16 - Programme controls

Abstract

The present invention relates to markers for diagnosing blood-brain barrier damage caused by alpha-synuclein, and a use thereof. Particularly, the present invention relates to: a marker composition for diagnosing blood-brain barrier (BBB) damage caused by alpha-synuclein, comprising an mRNA of one or more genes selected from the group consisting of ADAM8, C1S, C3, CCL2, CCL20, CCL5, CD83, CSF2, CSF3, CX3CL1, CXCL1, CXCL10, CXCL11, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8, EBI3, IL1B, KYNU, LTB, MMP10, PAPLN, TNC, TNFRSF9 and VNN1, or a protein of the gene(s); a composition for diagnosing alpha-synucleinopathy, comprising a substance for measuring the level of the mRNA or protein of the gene(s); a diagnostic kit; and a method for providing information for predicting or diagnosing alpha-synucleinopathy.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

An artificial intelligence device according to an embodiment of the present disclosure may comprise a memory and a processor for: training a binary classifier which infers whether a patch is a positive patch or a negative patch by using positive patches indicating normality and negative patches indicating abnormality on the basis of a normal sample indicating a non-defective product and an unlabeled sample; when the reliability of a patch output in response to a patch of a new unlabeled sample input to the trained binary classifier is greater than or equal to threshold reliability, determining the input patch as a positive patch; and storing the determined positive patch in the memory.

IPC Classes  ?

• G01N 21/88 - Investigating the presence of flaws, defects or contamination
• G06F 18/214 - Generating training patternsBootstrap methods, e.g. bagging or boosting
• G06N 3/045 - Combinations of networks
• G06N 3/091 - Active learning
• G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning
• G06T 7/00 - Image analysis

Abstract

The present invention offers a vertical culture slide device for tissue or cell culture, wherein a cultivation space for culturing cells or tissues is formed between a pair of slides equipped to face each other at a certain distance to provide a cultivation environment that allows for the real-time observation and recording of cell division, growth, and differentiation patterns while cultivating various tissues and organs with layered structures, whereby structural and physiological characteristics that emerge during the cultivation of cells, biological tissues, organoids, artificial skin, and other biological cultures forming multi-layered structures can be observed and measured in real-time, thus facilitating the study of tissue development processes, responses to drugs, and structural or physical changes due to genetic mutations.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

A dynamic service caching method reflecting a real-time edge computing use rate, according to an embodiment of the present invention, comprises the steps of: configuring a virtual queue for predicting a workload for each of a mobile server, an edge server, and a cloud server; predicting a workload according to service caching for the edge server and the cloud server by using the virtual queue and detecting each expected size of service delay on the basis of the predicted workload; and determining actual service caching for any one of the edge server and the cloud server on the basis of the detected size of the service delay.

IPC Classes  ?

• H04L 67/59 - Providing operational support to end devices by off-loading in the network or by emulation, e.g. when they are unavailable
• H04L 43/0852 - Delays
• H04L 67/60 - Scheduling or organising the servicing of application requests, e.g. requests for application data transmissions using the analysis and optimisation of the required network resources
• H04L 67/101 - Server selection for load balancing based on network conditions
• G06F 11/30 - Monitoring
• H04W 28/084 - Load balancing or load distribution among network function virtualisation [NFV] entitiesLoad balancing or load distribution among edge computing entities, e.g. multi-access edge computing

Abstract

The present disclosure provides a magnetic actuation system including a curved magnetic core forming a magnetic field or magnetic force through current supplied thereto to control a therapeutic magnetic actuation robot. The magnetic actuation system includes an electromagnet array including a plurality of electromagnets aligned in an arrangement space, wherein each of the plurality of electromagnets includes an electromagnet body linearly extending while including a magnetic core and a coil wound around the magnetic core, and a magnetic core front end portion extending from the magnetic core to protrude from the electromagnet body, and the magnetic core front end portions of the plurality of electromagnets are oriented to be bent toward a target position.

IPC Classes  ?

• H01F 7/08 - ElectromagnetsActuators including electromagnets with armatures
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

The present specification relates to a magnetically actuated anti-cancer cell robot in which T cells or CAR-T cells are combined with magnetic nanoparticles by biotin-streptavidin binding, and a method for manufacturing same.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes

Abstract

A battery cell defect detection device according to one embodiment of the present invention comprises: a current application jig for pressing and fixing an electrode lead of a battery cell; and a conductive plate arranged on one surface of the battery cell at a position corresponding to an electrode of the battery cell, wherein the conductive plate includes a body having the same shape as the electrode of the battery cell and having a uniform thickness, a reverse current having a polarity opposite to that of a current applied to the battery cell is applied to the conductive plate, and the sum of magnetic fields induced from each of the current and the reverse current is measured to detect a steady magnetic field that occurs in a defective region of the battery cell, and thus the defective region of the battery cell is detected.

IPC Classes  ?

• G01R 31/392 - Determining battery ageing or deterioration, e.g. state of health
• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 31/52 - Testing for short-circuits, leakage current or ground faults
• H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte

Abstract

An apparatus includes one or more processors configured to execute instructions; and one or more memories storing the instructions; wherein the execution of the instructions by the one or more processors configures the one or more processors to generate an approximate polynomial, approximating a neural network operation, of a portion of a deep neural network model that is configured to receive input data, by using weighted least squares based on parameters corresponding to the generation of the approximate polynomial, a mean of the input data, and a standard deviation of the input data; and generate a homomorphic encrypted data operation result based on the input data and the approximate polynomial that approximates the neural network operation.

IPC Classes  ?

• G06N 3/048 - Activation functions
• G06F 17/17 - Function evaluation by approximation methods, e.g. interpolation or extrapolation, smoothing or least mean square method
• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols

Abstract

An apparatus and method with encrypted data neural network operation is provided. The apparatus includes one or more processors configured to execute instructions and one or more memories storing the instructions, wherein the execution of the instructions by the one or more processors configures the one or more processors to generate a target approximate polynomial, approximating a neural network operation, of a portion of a neural network model, using a determined target approximation region, for the target approximate polynomial, based on a first approximate polynomial generated based on parameters corresponding to a generation of the first approximate polynomial, a maximum value of input data to the portion of the neural network layer, and a minimum value of the input data, and generate a neural network operation result using the target approximate polynomial and the input data.

IPC Classes  ?

• G06N 3/048 - Activation functions
• G06N 3/08 - Learning methods

Abstract

The present invention relates to a composition for single-cell proteomics analysis, a sample treatment method using same, and a method for unifying the labeling of ultra-small amounts of peptides. Particularly, the present invention relates to: a sample pretreatment composition for quantitative protein analysis, the sample pretreatment composition comprising a sulfobetaine-based amphoteric surfactant and N,N,N',N-tetrakis(2-hydroxypropyl)ethylenediamine as active ingredients; a sample pretreatment tube for quantitative protein analysis using the sample pretreatment composition, in which a centrifugal separation tube is equipped with a thin film having a plurality of micro through-holes; and a method for unifying and preparing a sample for quantitative protein analysis, the method comprising the steps of injecting a biological sample into micro through-holes provided in the sample pretreatment tube for quantitative protein analysis according to the present invention, treating the micro through-holes with the sample pretreatment composition for quantitative protein analysis, the sample pretreatment composition comprising a sulfobetaine-based amphoteric surfactant and N,N,N',N-tetrakis(2-hydroxypropyl)ethylenediamine as active ingredients, and allowing a reaction to occur, and when the reaction is completed, centrifuging the sample pretreatment tube in a centrifuge to obtain a pretreated sample collected at the bottom of the tube.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 30/72 - Mass spectrometers
• G01N 1/28 - Preparing specimens for investigation

Abstract

The present invention relates to use of an odorant receptor for suppressing the lactate-induced M2-type differentiation of tumor-associated macrophages and tumor growth. In particular, the inventors of the present invention assumed that lactate-activated OR Olfr78 would function as a macrophage lactate sensor, and confirmed whether Olfr78 on bone marrow-derived macrophages (BMDMs) detect tumor-derived lactate and lactate-induced M2 polarization. The inventors of the present invention attempted to identify factors detected by Olfr78 in tumor conditioned media (TCM), and discovered that lactate in TCM and acetic acid under some conditions are major factors involved in Olfr78-mediated generation of tumor-friendly M2-TAMs. Finally, it was found that Olfr78 deficiency inhibited tumor progression and metastasis and improved antitumor immunity in vivo (in vivo). According to the present invention, Olfr78-lactate interaction plays a major role in tumor progression, and thus, targeting of the Olfr78-lactate axis can be effectively used in targeted cancer therapy.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present disclosure provides a 3D object detection correction apparatus and method. The 3D object detection correction apparatus includes a processor configured to detect a 3D object based on image data. The processor is also configured to correct an error of the detected 3D object based on a difference value of camera information of a vehicle. The 3D object detection correction apparatus also includes a storage configured to store data and algorithms executable by the processor.

IPC Classes  ?

• G06V 20/64 - Three-dimensional objects
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle

Abstract

The present disclosure relates to a method of manufacturing a field effect transistor array by direct carbon nanotube printing and a field effect transistor array manufactured by the same. In addition, the method of manufacturing a field effect transistor array according to the present disclosure can implement deposition by adjusting a concentration of carbon nanotubes at a desired location on a substrate without limiting the substrate and very easily control a location by printing carbon nanotubes at an electrode gap location, and since the carbon nanotubes do not contact oxides of the substrate, lower noise to implement excellent sensitivity. In addition, the method of manufacturing a field effect transistor array according to the present disclosure can significantly reduce manufacturing costs and processing time by printing carbon nanotubes at a desired location without additional processes, and can be applied to various devices through a low-temperature process.

IPC Classes  ?

• H01L 29/66 - Types of semiconductor device
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 27/088 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 29/775 - Field-effect transistors with one-dimensional charge carrier gas channel, e.g. quantum wire FET

Abstract

A magnetron sputtering device according to the present disclosure includes a chamber having a vacuum state therein, a gas supply pipe configured to supply argon (Ar) gas into the chamber, a sputtering head provided within the chamber and including a sputtering target and a magnetic body disposed on a bottom end of the sputtering target to generate a magnetic field, a power supply configured to supply current to the sputtering target to generate plasma, a cooling device including a refrigerant pipe, through which refrigerant circulating from outside the chamber to the sputtering head, flows and configured to cool the sputtering head to a low temperature, a sputtering shield surrounding an area of the refrigerant pipe located outside the chamber and including a refrigerant inlet and a refrigerant outlet communicating with the refrigerant pipe, wherein the sputtering shield including a communication hole communicating with the chamber to have a vacuum state therein and the refrigerant pipe delivers the refrigerant while being disposed in a dual vacuum structure, wherein in the dual vacuum structure, an area of the refrigerant pipe located outside the chamber is disposed within the sputtering shield having the vacuum state, and an area of the refrigerant pipe located between the sputtering shield and the sputtering head is disposed within the chamber having the vacuum state.

IPC Classes  ?

• H01J 37/34 - Gas-filled discharge tubes operating with cathodic sputtering
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
• C23C 14/56 - Apparatus specially adapted for continuous coatingArrangements for maintaining the vacuum, e.g. vacuum locks
• H01J 37/18 - Vacuum locks

Abstract

Various embodiments of the present invention pertain to a microstructure for actively sampling microbes, which can easily sample and recover intestinal microbes, and a method of actively sampling microbes by using same. The microstructure for actively sampling microbes may comprise: a core including magnetic nanoparticles, a reaction initiator, and a polymer monomer; and a shell surrounding the core and including a fatty acid.

IPC Classes  ?

• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements

Abstract

The present invention provides an electronic brake device, comprising: a driving unit that provides driving force; a power transmission unit having a drive shaft that is connected to one side of the driving unit and rotates in a first direction or a second direction by means of the driving force; a differential gear unit connected to one side of the power transmission unit; a power distribution unit having a first driven shaft connected to one side of the differential gear unit and a second driven shaft connected to the other side of the differential gear unit; and a transmission gear unit that receives the driving force from the first driven shaft and the second driven shaft and provides the driving force to a pressing unit that applies braking force to a disc, wherein the drive shaft rotates in the first direction or the second direction such that the pressing unit may selectively apply the braking force to the disc.

IPC Classes  ?

• B60T 13/74 - Transmitting braking action from initiating means to ultimate brake actuator with power assistance or driveBrake systems incorporating such transmitting means, e.g. air-pressure brake systems with electrical assistance or drive
• B60T 1/06 - Arrangements of braking elements, i.e. of those parts where braking effect occurs acting by retarding wheels acting otherwise than on tread, e.g. employing rim, drum, disc, or transmission
• F16D 65/18 - Actuating mechanisms for brakesMeans for initiating operation at a predetermined position arranged in or on the brake adapted for drawing members together

Abstract

Various embodiments of the present invention are: a biological material delivery structure that allows accurate delivery to a treatment site without loss of bacteria or drugs; and a biological material delivery method using same, the biological material delivery structure comprising: a core layer including a biological material supported therein; and a first outer layer disposed on the core layer and including magnetic nanoparticles supported therein, wherein the core layer includes a first alginate, and the second outer layer includes a second alginate.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 35/74 - Bacteria
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Abstract

An artificial intelligence inference and training system using SSD offloading, according to one embodiment of the present invention, comprises: storage servers for storing data and comprising a plurality of SSDs which each comprise a first computing device; a transfer learning server connected to the storage servers via a network and generating an artificial intelligence model which is updated through periodic training; an inference server for extracting metadata for the data by using the artificial intelligence model received from the transfer learning server; and a database for storing the extracted metadata, wherein the transfer learning server comprises a second computing device, and a first part of the training is carried out through the first computing devices, and a second part, including the remaining training parts other than the first part of the training, is carried out through the second computing device.

IPC Classes  ?

• G06N 3/098 - Distributed learning, e.g. federated learning
• G06N 3/096 - Transfer learning
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 5/04 - Inference or reasoning models
• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

The present invention relates to a carbon structure, which can stably support a high content of sulfur in pores and has excellent electrical conductivity properties, wherein the carbon structure is a polyhedron, of which the center on at least one side is concave, and is a highly graphitized nitrogen-doped porous carbon structure. Therefore, the stability of lithium-sulfur batteries can be improved by effectively suppressing a shuttle phenomenon occurring during an electrochemical reaction of lithium-sulfur batteries containing, as a cathode active material, the carbon structure supporting sulfur as well as minimizing the volume change resulting from sulfur and reduced lithium sulfide.

IPC Classes  ?

• C01B 32/05 - Preparation or purification of carbon not covered by groups , , ,
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators

Abstract

The present invention relates to a pharmaceutical composition for the prevention or treatment of degenerative brain diseases, comprising olmutinib as an active ingredient and, particularly, to a pharmaceutical composition and a health functional food composition for the prevention or treatment of neuroinflammation or degenerative brain diseases, comprising, as an active ingredient, olmutinib or a pharmaceutically acceptable salt thereof. In addition, the present invention relates to a composition for protecting nerve cells damaged by excessive inflammatory responses in nerve cells, a reagent composition for inhibiting the activation of microglia or astrocytes, and a reagent composition for inhibiting tau hyperphosphorylation or tau kinase activation.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention provides a motion tracking device comprising: a marker tracking unit, which photographs a detection marker attached to a preset area of a human body so as to generate a marker image; a photographing unit, which photographs the human body so as to generate a human body image; and a processor unit, which receives the marker image from the marker tracking unit so as to detect marker information, receives the human body image from the photographing unit so as to detect the frame information, and uses the marker information and the frame information so as to derive operation information about the human body.

IPC Classes  ?

• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/277 - Analysis of motion involving stochastic approaches, e.g. using Kalman filters
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 7/60 - Analysis of geometric attributes

Abstract

The present disclosure relates to an automation method and device for cognitive rehabilitation training and, more specifically, to an automation method and device for cognitive rehabilitation training, in which an automation system is established that analyzes training information of a subject participating in cognitive rehabilitation training and derives the appropriateness of difficulty to update a training schedule, thus enabling training design in consideration of the subject's characteristics, and flexible training update according to the subject's progress.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention provides a system for sharding-based key-value caching, the system comprising: a key-value storage including a plurality of SSDs; a key-value director for processing a caching request of key-value pairs of the key-value storage, the caching request received from a client; and a key-value shard for receiving and indexing the caching request having been received by the key-value director, and processing inputs and outputs of the key-value pairs from the key-value storage, wherein a plurality of the key-value shards are provided, and each of the plurality of the key-value shards manages at least one of the plurality of SSDs.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 12/02 - Addressing or allocationRelocation

Abstract

The present invention provides a robot and a method for estimating the position of a robot. The robot may comprise: a main body unit that forms the exterior of the robot and includes a driving unit; a sensor unit disposed in the main body unit and including a vision camera unit that takes images of an object, a depth sensor unit that acquires depth information, and a marker tracking unit that tracks the position of a marker attached to the object; and a processor that receives image information, depth information, and marker information from the sensor unit, derives position information of the object, and estimates position information of the robot by using the position information of the object.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 5/00 - Manipulators mounted on wheels or on carriages
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B25J 19/02 - Sensing devices
• G05D 1/02 - Control of position or course in two dimensions

Abstract

The present invention relates to an electroluminescent device and a method for manufacturing same. An electroluminescent device according to one embodiment comprises a lower electrode layer, an electroluminescent device layer, and an upper transparent electrode layer stacked on a substrate, wherein the upper transparent electrode layer may be an electrode formed by coating a transparent film substrate with a metal nano thin film.

IPC Classes  ?

• H10K 50/828 - Transparent cathodes, e.g. comprising thin metal layers
• H10K 50/81 - Anodes
• H10K 77/10 - Substrates, e.g. flexible substrates
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 71/00 - Manufacture or treatment specially adapted for the organic devices covered by this subclass
• H10K 50/856 - Arrangements for extracting light from the devices comprising reflective means

Abstract

The present invention relates to a surface acoustic wave-based material measuring device, material measuring system, and material measuring method, and more particularly, to a technique of accurately and reliably measuring various inherent physical properties of temperature and frequency-dependent materials by generating multiple resonant waves.

IPC Classes  ?

• G01N 29/02 - Analysing fluids
• G01N 29/036 - Analysing fluids by measuring frequency or resonance of acoustic waves
• G01N 29/24 - Probes
• G01N 29/32 - Arrangements for suppressing undesired influences, e.g. temperature or pressure variations

Abstract

The present invention provides a variable-resistance exercise device, and may comprise: a power provision part, which is supplied with a power source from the outside so as to provide power; a power distribution part which is connected to one side of the power provision part, and which has a first shaft and a second shaft at both sides thereof and a differential gear, which controls power distribution so as to transmit distributed power to the first shaft and the second shaft; an action part connected to the first shaft so as to receive the distributed power, thereby rotating in a first direction; a handle part connected to the action part so as to provide, to the action part, a load in the direction opposite to the first direction; and a braking part which is connected to the second shaft, and which generates braking force corresponding to the load so that the magnitude of the power distributed to the handle part can be controlled.

IPC Classes  ?

• A63B 21/005 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using electromagnetic or electric force-resisters
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices

Abstract

Disclosed is a particle-measuring device, including: a measurement part including first and second electrodes and measuring a mass of particles with a change in signals transmitted and received between the first and second electrodes, wherein the first and second electrodes are patterned on a base made of a piezoelectric material and transmit/receive signals to/from each other; and an adsorption part provided in an adsorption region between the first and second electrodes and configured to adsorb fine particles according to a temperature change. According to such a configuration, the particle-measuring device does not interfere with the resonance rate of a piezoelectric material while having a high adsorption rate, thereby providing excellent particle measurement quality.

IPC Classes  ?

• G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
• G01N 15/10 - Investigating individual particles

Abstract

Provided is a magnetic actuation system controlling a magnetic microrobot, a magnetic actuation catheter, or a guide wire by using a magnetic field, and more particularly, a magnetic actuation system compatible with a C-arm that is applied to the C-arm, which is a mobile X-ray fluoroscopy device, in order to enable control of the microrobot or a catheter treatment in a human body by using the C-arm.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery

Abstract

The present disclosure relates to an anodizing apparatus that may include: a body; a jig tray disposed inside the body and having a plurality of coupling holes formed to pass therethrough in an upward and downward direction thereof; a plurality of jigs detachably coupled correspondingly to the plurality of coupling holes of the jig tray to fix a plurality of objects to be anodized thereto at a time; and an anodizing unit adapted to perform an anodizing process for the plurality of objects to be anodized and having a plurality of accommodation parts for storing electrolytes therein.

IPC Classes  ?

• C25D 11/00 - Electrolytic coating by surface reaction, i.e. forming conversion layers
• C25D 17/02 - TanksInstallations therefor
• C25D 17/06 - Suspending or supporting devices for articles to be coated
• C25D 21/02 - Heating or cooling
• C25D 21/12 - Process control or regulation

Abstract

Disclosed are porous multi-metal oxide nanotubes and a production method therefor. In one aspect, methods for producing porous multi-metal oxide nanotubes are provided comprising: (a) preparing an admixture comprising metal-acetylacetonate precursors, polyacrylonitrile (PAN) and a solvent component; and (b) producing a nanocomposite from the admixture, wherein metals of the metal-acetylacetonate precursors comprise a non-radioactive alkali metal stable isotope and a non-radioactive alkaline earth metal stable isotope. As such, porous multi-metal oxide nanotubes having a single-phase multivalence may be obtained in high yield without using harmful chemical substances. In addition, the polymer electrolyte membrane including the porous multi-metal oxide nanotubes may have maintained and improved mechanical strength, and thus may have maintained durability even during cell operation and may also have improved proton conductivity even at low humidity. The fuel cell including the polymer electrolyte membrane may have improved performance.

IPC Classes  ?

• D01F 9/10 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments of inorganic material by decomposition of organic substances
• D01D 5/00 - Formation of filaments, threads, or the like
• H01M 8/10 - Fuel cells with solid electrolytes

Abstract

Provided are a magnetic actuation device using a permanent magnet which may generate a magnetic field for a long time with lower power and lower heat by using the permanent magnet, and a system using the same. The magnetic actuation device may utilize the plurality of permanent magnets for controlling an alignment direction with two degrees of freedom to thus exclude an actuation element limiting space utilization, such as a robot arm, thus allowing an operator using a medical device to perform a safe procedure on a patient.

IPC Classes  ?

• H01F 7/02 - Permanent magnets
• H01F 7/20 - ElectromagnetsActuators including electromagnets without armatures

Abstract

The present invention provides a hydrophilically and hydrophobically surface-treated metal plate comprising: a plate made of a metal; a hydrophilic surface layer hydrophilically formed by oxidizing and etching the surface of the plate; and a hydrophobic surface layer hydrophobically formed by applying a polymer and/or a lubricant to the surface of the plate.

IPC Classes  ?

• B05D 5/08 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface
• B05D 7/14 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
• C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
• C09D 183/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
• C09D 127/12 - Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogenCoating compositions based on derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
• C23C 22/64 - Treatment of refractory metals or alloys based thereon

Abstract

The present invention relates to a method for manufacturing a polymer-based microneedle patch designed to maximize skin penetration performance. The polymer-based microneedle patch of the present disclosure can be manufactured to have enhanced penetration power and flexibility as microneedles formed of a polymer with both rigidity and flexibility are combined with an elastic and breathable substrate.

IPC Classes  ?

• B29C 39/02 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor for making articles of definite length, i.e. discrete articles
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B29C 39/26 - Moulds or cores
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B29C 39/42 - Casting under special conditions, e.g. vacuum
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• C09D 183/04 - Polysiloxanes
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A liquid metal-based shape driving device of the present invention comprises: a device having a predetermined modulus; a first liquid metal coil coupled to a specific part of the device having a predetermined modulus, and having a shape which changes according to a magnetic field generated when current is applied; and a base which is spaced apart in a first direction and in parallel with the first liquid metal coil having the shape that changes according to the magnetic field generated when current is applied, and generates the magnetic field with respect to the first liquid metal coil having the shape that changes according to the magnetic field generated when current is applied.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
• H01F 1/03 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity
• H01F 1/44 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids

Abstract

Provided are a novel nickel foam having a hierarchical pore structure, a method of producing the same, and an application thereof. Unlike a conventional nickel foam, the nickel foam has a well-developed hierarchical pore structure including pores having a size of 4 μm or less in addition to inherent macropores having a size of 100 μm to 900 μm, and thus, may have a significantly large specific surface area. Accordingly, the nickel foam may be variously applied to an electrochemical reaction such as a water electrolysis system and an exhaust gas purification filter.

IPC Classes  ?

• C25B 11/031 - Porous electrodes
• B01D 53/86 - Catalytic processes
• B01J 23/72 - Copper
• B01J 23/755 - Nickel
• B01J 35/56 - Foraminous structures having flow-through passages or channels, e.g. grids or three-dimensional monoliths
• B01J 35/61 - Surface area
• C23F 1/12 - Gaseous compositions
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/061 - Metal or alloy
• H01G 11/30 - Electrodes characterised by their material
• H01G 11/52 - Separators

Abstract

The present invention relates to a technology for generating a stray field having a magnetic field direction according to an outer magnetic field by using a magnetic field conversion unit based on a magnetic particle, and detecting a magnetic field direction of the stray field through a magnetic sensor to detect a three-axis magnetic field. A three-axis magnetic field detection device according to an embodiment of the present invention may include a magnetic field conversion unit for generating a stray field having a magnetic field direction according to a magnetic field direction of an outer magnetic field by using a magnetic particle, a magnetic field measurement unit for measuring a magnetic field direction with respect to an X-axis magnetic field, a Y-axis magnetic field, and the stray field in relation to the outer magnetic field, and a magnetic field detection unit for detecting the X-axis magnetic field, the Y-axis magnetic field, and a Z-axis magnetic field on the basis of the measured magnetic field direction.

IPC Classes  ?

• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables

Abstract

A multicast switch array and a multi-beam steering device using the same are provided. Accordingly, it is possible to precisely steer a large-scale multi-beam.

IPC Classes  ?

• G02B 6/35 - Optical coupling means having switching means
• G02B 6/34 - Optical coupling means utilising prism or grating

Abstract

Provided is a pharmaceutical composition for enhancing the anticancer effect of cancer. More specifically, it was confirmed that when a composition including an IU1-series compound known to inhibit ubiquitin-specific protease 14 (USP14), which is a deubiquitinase, is administered in combination with and proteolysis-targeting chimera (PROTAC), the cancer prevention or treatment effect of PROTAC was significantly enhanced. Furthermore, with the pharmaceutical composition of the present disclosure, cancer can be effectively treated even when a lower dose of PROTAC is used, thereby freeing from the problems of toxicity and side effects, and improving the application limitations and problems arising from the sole use of PROTAC. Accordingly, the combinatorial treatment of PROTAC and IU1-series compound can be widely used in the field of cancer treatment.

IPC Classes  ?

• A61K 31/4412 - Non-condensed pyridinesHydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a composition for treating a cancer disease, comprising an extracellular vesicle derived from natural killer cells with surface expression of cytokine and an antibody. By expressing IL-15 and a cancer cell-specific antibody on the surface of human natural killer cells, it is possible to provide an extracellular vesicle that can exhibit strong cytotoxic activity specifically against cancer cells. The extracellular vesicle can be provided as a new anticancer agent that is safe for the human body and exhibits an excellent anticancer effect. In addition, the extracellular vesicle of the present invention can be used to deliver drugs or bioactive substances to specific cancer cells by encapsulating the drugs or bioactive substances having a therapeutic effect on cancer therein, and thus can be provided as a new means of treating cancer.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/50 - Microcapsules
• A61P 35/00 - Antineoplastic agents
• A61K 39/00 - Medicinal preparations containing antigens or antibodies