Medical supplies for the hospital operating room, namely, foam positioners and positioning straps, magnetic and foam needle counting apparatus, needle and blade counting and disposal apparatus, surgical needle finders, clamps, markers, foam instrument sheaths, surgical vessel loops, disposable light handles, light adapters for use with operating room lights, surgical tube holders, cautery instrument tip polishers and wipes, and sterile anti-fog solution for anti-fog treatment and cleaning endoscopic lenses, surgical cameras, and protective eyewear during surgical procedures
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Sensors for tracking wetness in adult incontinence underwear and briefs; Downloadable computer and downloadable mobile application software for use with sensors that track wetness in adult incontinence underwear and briefs. (1) Software as a service (SAAS) services featuring software for use with monitoring and tracking wetness in patients' adult incontinence briefs and underwear.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Sensors for tracking wetness in adult incontinence underwear and briefs; Downloadable computer and downloadable mobile application software for use with sensors that track wetness in adult incontinence underwear and briefs. Software as a service (SAAS) services featuring software for use with monitoring and tracking wetness in patients' adult incontinence briefs and underwear
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Sensors for tracking wetness in adult incontinence underwear and briefs; computer and mobile application software for use with sensors that track wetness in adult incontinence underwear and briefs. (1) Software as a service (SAAS) services featuring software for use with monitoring and tracking wetness in patients' adult incontinence briefs and underwear.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing consumer product information to medical providers on skin care products and services for the treatment of skin issues associated with incontinence and skin care Providing medical information to medical providers on skin care products and services for the treatment of skin issues associated with incontinence and skin care
(1) Transcutaneous electrical nerve stimulation electrode patches for medical use, reusable hot and cold gel packs for medical use and therapeutic compression wraps.
Transcutaneous electrical nerve stimulation electrode patches for medical use, reusable hot and cold gel packs for medical use, and therapeutic compression wraps
Enteral feeding tubes; medical apparatus and instruments for use with enteral feeding; enteral feeding pumps for medical purposes; medical apparatus, namely, infusion devices for treatment
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing medical information to medical providers on skin care products and services for the treatment of skin issues associated with incontinence, negative pressure wound therapy, wound care and skin care
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing consumer product information to medical providers on skin care products and services for the treatment of skin issues associated with incontinence, negative pressure wound therapy, wound care and skin care Providing medical information to medical providers on skin care products and services for the treatment of skin issues associated with incontinence, negative pressure wound therapy, wound care and skin care
(1) Enteral feeding products, namely, enteral feeding pumps, tubes and bags; enteral feeding sets consisting primarily of vinyl bags and tubing; irrigation kits comprised of medical irrigators for flushing and cleaning the tubing of enteral feeding sets and to provide irrigation and hydration to the patient through enteral feeding.
Enteral feeding products, namely, enteral feeding pumps; enteral feeding products, namely, enteral feeding tubes; bags specifically adapted for use with enteral feeding pumps and tubes; enteral feeding sets consisting primarily of medical tubing and vinyl bags specifically adapted for use with enteral feeding pumps
Described are various embodiments of an improved endoprosthesis that includes a generally cylindrical graft portion that extends along a longitudinal axis to define a flow passage and a plurality of stent hoops. The plurality of stent hoops are connected to the graft portion and disposed in a spaced apart relationship along the longitudinal axis. There is at least a first suture disposed along on the outer surface of the main body. The first suture connects at least two of the spaced apart stent hoops together. The first suture also includes unidirectional barbs (or multidirectional barbs) configured to reduce movement of the main body with respect to a direction of blood flow in an artery.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
36.
THIN-FILM COMPOSITE RETRIEVABLE ENDOVASCULAR DEVICES AND METHOD OF USE
Various embodiments for a composite endovascular device (100) (and variations thereof) that include an inner polymer structure (102) and an outer thin-film shape memory structure (106). The inner polymer structure extends from a distal end to a proximal end along a longitudinal axis (L). The outer thin-film shape-memory structure has an inner thin-film surface coupled to the outer surface (102b) of the inner polymer structure from the distal end to the proximal end with a retrieval member (108) at the proximal end to allow for the prosthesis to be retrieved after placement in a body vessel. The inner polymeric structure can be blended with a suitable bio-active agent or the agent can be loaded into the pores. The device can be permanent or temporary by virtue of being retrievable.
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
A61F 2/01 - Filters implantable into blood vessels
The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises an expandable member releasably or permanently affixed to a delivery system which facilitates placement and advancement of a second delivery system.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
Gloves for medical use; medical gowns; IV bag seals; medical waste bags, bags to transport chemotherapy drugs for medical purposes; safety glasses and goggles for medical use; contamination control floor mats for medical use Disposable absorbent floor pads
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
A61B 17/03 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith
A61F 2/01 - Filters implantable into blood vessels
A61F 13/36 - Surgical swabs, e.g. for absorbency or packing body cavities during surgery
A61F 13/53 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the absorbing medium
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
This disclosure is directed to systems and methods for providing a guiding device having a dilatable, drilling tip. The tip is formed by wound helical members such that resistance to rotation in an unwinding direction dilates the tip. The helical members are configured so that the dilatable tip increases in stiffness when the helical members are tensioned by a resistance to rotation in the winding direction. In some embodiments, application of relative force between coaxial inner and outer tubular members is used to control the dilation, stiffness and drilling of the guiding member.
This disclosure is directed to systems for re-entering the true lumen of a vessel. The re-entry catheters employ deflectable struts to stabilize and support the distal tip in a subintimal location while a passageway back into the true lumen is formed. Re-entry to the true lumen can be effected with a cutting element or with a conventional guidewire.
A method for determining either the mass of one or more drops dispensed from an inkjet dispensing device or the concentration of dissolved solutes form one or more drops of a liquid of interest dispensed from an inkjet dispensing device utilizes UV visible spectroscopy. The UV absorption spectra o the constituents of the solution may be compared to predetermined calibration curves to accurately determine mass and concentrations of a single drop.
G01G 9/00 - Methods of, or apparatus for, the determination of weight, not provided for in groups
G01G 17/04 - Apparatus for, or methods of, weighing material of special form or property for weighing fluids, e.g. gases, pastes
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
The establishment of a stable acoustic environment within the individual channels of an inkjet printing device functions to allow the inkjet printing device to precisely deposit the same amount of a particular substance at one or more locations on an object. This is particularly relevant when the inkjet printing device is operated in the on-demand mode of operation.
The present invention relates to tubular stents that are implanted within a body lumen. The stent (1400) has a cylindrical shape defining a longitudinal axis and includes a helical section (1408) and a closed endless ring section (1420) within the helical section. The helical section has of a plurality of longitudinally oriented strut members (1413) and a plurality of circumferentially oriented hinge members (1414) connecting circumferentially adjacent strut members to form a band, the band being wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. The closed ring section interrupts the repeating helical pattern and separates the helical section into a proximal helical section and a distal helical section. The intermediate ring section includes a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form an endless ring.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
The present invention relates to tissue - supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members (113) and a plurality of circumferentially oriented hinge members (114c) connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between adjacent windings.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
49.
FLEXIBLE HELICAL STENT HAVING DIFFERENT HELICAL REGIONS
The present invention relates to tubular stents that are implanted within a body lumen. The stent (1500) has a cylindrical shape defining a longitudinal axis and includes a proximal helical section (1506), a distal helical section (1507) and an intermediate ring section (1520) there between. Each of the proximal and distal helical sections has of a plurality of longitudinally oriented strut members (1513) and a plurality of circumferentially oriented hinge members (1154) connecting circumferentially adjacent strut members to form a band, the band being wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings, wherein the distal helical section is wound about the longitudinal axis in the opposite direction from the proximal helical section. The intermediate ring section includes a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form an endless ring.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
50.
FIRST DROP DISSIMILARITY IN DROP-ON-DEMAND INKJET DEVICES AND METHODS FOR ITS CORRECTION
A number of methods may be utilized to correct for the first drop dissimilarity in drop-on-demand inkjet devices. Various collection processes, mass calculations and timing manipulation may be utilized to correct the first drop dissimilarity problem.
Mechanisms for pulling a tensile member (24) a predetermined distance from a medical device (10) having an intracorporeal end and an extracorporeal end are disclosed. Such mechanisms may be safely operated using a robot, two hands, or in some embodiments, only one hand. Such mechanisms may include one or more cams, drums, or pulley- like members (34) and a lever (48), and may be physically coupled to an extracorporeal portion of the medical device.
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
A61M 29/02 - Inflatable dilatorsDilators made of swellable materials
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
The present invention relates to tissue-supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between longitudinally adjacent helical windings of the band.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
The present invention relates to tissue-supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between longitudinally adjacent helical windings of the band.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
The present invention relates to tissue-supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between longitudinally adjacent helical windings of the band.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Modified suture knots may be utilized to effective anchor one stent-graft to another stent-graft wherein the stent-grafts are normally connected via an interference fit in an overlap configuration. The sutures that are utilized to affix the graft material to the underlying stent structure may be modified to have a profile that allow it to lock and secure it to another stent-graft or a vessel into which it is implanted.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A stent attachment and deployment mechanism is utilized to prevent the distal end of an endoprosthesis comprising fixation barbs or other fixation mechanism from deploying prior to the remaining sections of the fixation device. With this stent attachment and deployment mechanism accurate deployment may be achieved.
Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue and/or the bloodstream.
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to:the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
61.
DEFLECTING GUIDE CATHETER FOR USE IN A MINIMALLY INVASIVE MEDICAL PROCEDURE FOR THE TREATMENT OF MITRAL VALVE REGURGITATION
A deflecting guide catheter for use in minimally invasive medical procedures such as the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The catheter includes an elongated tubular portion having various durometers along its length and at least one puller wire attached to an anchor band near the distal end. The deflecting guide catheter is used to provide a means for guiding a plication device or other medical instrument into a desired position within the vasculature or heart chambers of a patient.
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
A biocompatible metallic material may be configured into any number of implantable medical devices, including intraluminal stents. The biocompatible metallic material may comprise a magnesium alloy. The magnesium alloy implantable medical device may be designed to degrade over a given period of time. In order to control the degradation time, the device may be coated or otherwise have affixed thereto one or more coatings, one of which comprises a material for controlling the degradation time and maintain a pH neutral environment proximate the device. Additionally, therapeutic agents may be incorporated into one or more of the coatings on the implantable medical device.
Medical devices comprised of bonded joints are disclosed. The bonded joints comprise two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces are comprised of materials that are suitable for medical devices. Most preferably, Nitinol comprises at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device comprised of a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin is further comprised of a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device comprised of contiguous heterogeneous structural elements comprised of metallic members and non- metallic sections that are bonded together by a layer of phenoxy resin therebetween.
C09J 5/02 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving pretreatment of the surfaces to be joined
C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
66.
INTRAVASCULAR STENT HAVING IMPROVED DESIGN FOR LOADING AND DEPLOYING
A stent may be inserted into a vessel in order to open and then maintain the patency of the vessel. The stent has a strut design that increases the overall fatigue resistance of the stent. Each strut is tapered to better distribute strain and thus increase fatigue resistance. In addition, some of the struts may comprise protrusions to increase the pushability of the stent during loading into a delivery device.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
67.
EXTRACTION OF SOLVENTS FROM DRUG CONTAINING POLYMER RESERVOIRS
A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 31/14 - Materials characterised by their function or physical properties
A stent attachment and deployment mechanism is utilized to prevent the distal end of an endoprosthesis comprising fixation barbs or other fixation mechanism from deploying prior to the remaining sections of the fixation device. With this stent attachment and deployment mechanism accurate deployment may be achieved.
An aneurysmal repair system that utilizes a modified apex and delivery device is designed for accurate endoprosthesis delivery and deployment. The modified apex utilizes segments that overlap and hold one another down as well as the fixation barbs attached thereto. The delivery device holds or secures at least one section of the apex and may be easily released by retraction of a hold down member.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
70.
DEVICE FOR LOCAL AND/OR REGIONAL DELIVERY EMPLOYING LIQUID FORMULATIONS OF THERAPEUTIC AGENTS
A drug delivery device comprises an expandable member having an external surface and configured such that the external surface makes contact with surrounding tissue when the expandable member is expanded and a liquid formulation of a therapeutic agent affixed to the external surface of the expandable member and configured for release into surrounding tissue when the external surface of the expandable member makes contact with the expandable member, the liquid formulation comprising a taxane in a pharmaceutically effective dosage, one or more pharmaceutically acceptable solubility enhancers and water in the range from about one percent by weight to about seventy percent by weight, the liquid formulation comprising a final solution of taxane in the range from about 0.05mg/ml to about 15 mg/ml.
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61K 9/00 - Medicinal preparations characterised by special physical form
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61P 9/00 - Drugs for disorders of the cardiovascular system
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
72.
WEAVE MODIFICATION FOR INCREASED DURABILITY IN GRAFT MATERIAL
An aneurysmal repair system that utilizes a weave modification to increase the durability of the graft material. An additional material is affixed to the graft material proximate the area where it is attached to the underlying stent structure. Alternatively, or in addition to, the additional material may be attached to the elements attaching the graft to the underlying stent structure.
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
An aneurysmal repair system that utilizes a modified intraluminal scaffold apex and a delta stitch suture to secure graft material to the scaffold structure allows for no relative movement between the graft material and the scaffold structure. The absence of relative movement reduces the wear on the graft material.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61L 31/14 - Materials characterised by their function or physical properties
An aneurysmal repair system that utilizes a modified intraluminal scaffold apex and a delta stitch suture to secure graft material to the scaffold structure allows for no relative movement between the graft material and the scaffold structure. The absence of relative movement reduces the wear on the graft material.
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
78.
LAYER-BY-LAYER STEREOCOMPLEXED POLYMERS AS DRUG DEPOT CARRIERS OR COATINGS IN MEDICAL DEVICES
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned.
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 5/50 - Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
A61P 9/00 - Drugs for disorders of the cardiovascular system
A plurality of endoluminal segments axially connected by fiber bridges is disclosed. The endoluminal segments may either be balloon-expandable or self-expanding, with the preferred embodiment being superelastic nitinol. The intraluminal segments may possess a textured surface or at least one geometric feature per segment, preferably located at the apex of a strut pair comprising the intraluminal segment, preferably capable of serving as an anchoring point for the fiber bridges. These geometric features may transmit axially compressive loads during deployment from a device such as a catheter, and may further be capable of interlocking the endoluminal segments when constrained within a device such as a catheter. The fibers comprising the bridges may be polymeric, silk, collagen, bioabsorbable, or a blend thereof. The fiber network comprising the bridges may be regularly oriented, randomly oriented, localized, or continuous. Moreover, the intraluminal segments and fiber bridges may be individually impregnated with therapeutic material, or may both be impregnated with therapeutic material.
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
Medical apparatus and instruments; line of urological devices for surgical and medical purposes, namely, catheters, drain bags, urine meters, medical preparation trays, specimen collection kits and systems, vaginal irrigation bags, enema bags and buckets, and rectal tubes; none of the aforesaid being mobility apparatus for use in physiotherapy and rehabilitation.
82.
A COATING FOR A MEDICAL DEVICE HAVING AN ANTI-THROMBOTIC CONJUGATE
Methods for making comb-type antithrombotic conjugate wherein substantially all side chains of water soluble poly(vinyl alcohol) (PVA) are extended by ring-opening polymerization to form a copolymer wherein substantially all terminals are conjugated to an antithrombotic molecule. In addition, a method is provided for applying a coating comprising a comb-type anti-thrombotic conjugate to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the device. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising a comb-type anti-thrombotic conjugate may be applied over the inner drug-containing layers using, for example, a dip coating or spray coating process. Alternatively the comb-type antithrombotic conjugate may be used as a matrix material to encapsulate a pharmaceutical agent to form microspheres or nanospheres before depositing the microspheres or nanospheres onto a medical device.
C08F 261/04 - Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
A61L 33/10 - Heparin, heparinoid or derivatives thereof
C08G 63/91 - Polymers modified by chemical after-treatment
83.
BIOABSORBABLE POLYMER, NON-BIOABSORBABLE METAL COMPOSITE STENTS
Biocompatible materials may be configured into any number of implantable medical devices including intraluminal stents. The biocompatible material may comprise metallic and non-metallic materials in hybrid structures. In one such structure, a device may be fabricated with one or more elements having an inner metallic core that is not degradable with an outer shell formed from a polymeric material that is biodegradable. Additionally, therapeutic agents may be incorporated into the microstructure or the bulk material.
Biocompatible materials may be configured into any number of implantable medical devices including intraluminal stents. The biocompatible material may comprise metallic and non-metallic materials in hybrid structures. In one such structure, a device may be fabricated with one or more elements having an inner metallic core that is biodegradable with an outer shell formed from a polymeric material that is biodegradable. Additionally, therapeutic agents may be incorporated into the microstructure or the bulk material.
A61L 31/14 - Materials characterised by their function or physical properties
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
85.
AN APPARATUS AND METHOD FOR MAKING A POLYMERIC STRUCTURE
The apparatus and method for preparing a polymeric structure from which a number of medical devices may be constructed is described. The structures are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a stage and converted into a structure. The solvent is evaporated from the structure. The dried solution forms a structure that is removed from the stage and further dried before being stored in an inert environment. Thereafter, a medical device such as a stent may be constructed from the structure.
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different beneficial agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated.. The different beneficial agents may also be used to address different diseases, such as restenosis and acute myocardial infarction from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis.
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61K 9/00 - Medicinal preparations characterised by special physical form
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
A61L 33/04 - Use of organic materials, e.g. acetylsalicylic acid
A61L 33/10 - Heparin, heparinoid or derivatives thereof
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port
This invention concerns expandable intraluminal medical devices for use within a body passageway or duct, wherein the devices exhibit differing degrees of flexibility around the circumference of the device.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
This application relates to devices for navigating passageways in a body, and in particular, to a steerable catheter (630) that can be used to navigate the tortuous anatomy of a body's vasculature. In one embodiment of the invention the deflectable catheter comprises an inner catheter body (611) having a first strut spine member (615) and a cantilevered second strut tang member (614). An outer catheter body (607) is cooperatively associated with the second strut tang member and an actuator (606) is cooperatively associated with the first strut spine member. The actuator is slideably engaged within the outer catheter body.
The present invention generally relates to medical devices, particularly to a SDS (stent delivery system) that incorporates a spring stent stop. The delivery system, owing to a novel stent stop construction, can be assembled, with the crimped stent in place within the outer sheath of the device, to enable the device to be assembled with considerably greater efficiency by eliminating processes and component(s).
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
91.
SINGLE DISC INTRALUMINAL FIXATION PATENT FORAMEN OVALE CLOSURE DEVICE
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
An electronic thermometer is configured for selectable predictive modes based upon the same predictive algorithm. A mode selector is adapted for user selection between several modes of operation of the thermometer. Each mode of operation utilizes the same predictive algorithm for estimating the temperature of the subject before the thermometer reaches full equilibrium. Different modes offer users a selection for striking the appropriate balance between response time and precision, based upon user preferences and needs.
An electronic thermometer having ergonomic and efficiency features. The thermometer includes a display and a control panel, defined by at least one button, disposed above the display. The thermometer is easy and comfortable to hold and allows the user to operate the thermometer with one hand. The thermometer holds a probe and a container of probe covers in a convenient and compact configuration. A battery door is particularly constructed to avoid accidental opening. A bottom of the thermometer is formed to hold the housing in an upright position when the bottom is placed one a horizontal surface.
A delivery catheter for providing the percutaneous delivery of a plurality of vascular stents. One or more stops are provided in the delivery catheter between each of the plurality of stents. The stops be radiopaque to assist in deploying the stents at desired locations within the vasculature of a patient.
An endoluminal prosthesis, comprises a tubular graft comprising a graft material, said graft material including a pleat defining an inner fold material, an outer fold material, and an interposed material between said inner and outer fold materials, said pleat increasing the thickness of said graft material at the location of said please; a first stent including a first plurality of apexes in contact with said inner fold material; and a second stent including a second plurality of apexes in contact with said outer fold material, wherein said pleat can be at least partially unfolded to accommodate stent separation.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
97.
IMPLANTABLE MEDICAL DEVICE WITH ANNEALED POLYMER COATING
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Implantable coated medical devices may be processed through annealing to better control the elution characteristics of the therapeutic agents. Furthermore, annealing leads to better therapeutic agent stability and a larger device shelf-life.
B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
98.
A MEDICAL DELIVERY SYSTEM FOR DELIVERY OF A MEDICALLY USEFUL PAYLOAD
The present disclosure concerns a delivery system for delivering a medically useful payload through the vasculature to a site of interest in the patient's body. The medically useful payload may be a therapeutic device, such as a stent, and it may be a diagnostic tool, such as an imaging device. Owing to its structural attributes, the presently-inventive delivery system is well suited for carrying medical payload to and through vessel curvature and to branched regions (i.e., bifurcations) in same. Also, the device is well-suited to traveling through a vessel over a guiding element, such as a guidewire, which itself exhibits curvature.
A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
A61M 36/04 - Arrangements specially adapted for placing, e.g. inhaling or injecting, radioactive material within the body
99.
TWISTED ANCHORING BARB FOR STENT OF ABDOMINAL AORTIC ANEURYSM (AAA) DEVICE
A stent is provided for an endoprosthesis having a main body portion and two leg portions, particularly suitable for treatment of an abdominal aortic aneurism. The stent includes barbs that are twisted and shaped set to point radially outward. Each barb, as formed, points substantially perpendicular relative to the longitudinal axis of the stent, even when in a non-deployed configuration. The motion to move the barb into a deployed configuration for gripping tissue is a twisting motion which moves the barb from being substantially aligned with the circumference of the stent to extending radially outwards from the stent.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
An abdominal aortic aneurysm repair device having an access port may be utilized to percutaneously access the aneurismal sac without disturbing the repair. The access port has a self-sealing member for maintaining the port in the normally closed position. The insertion of a percutaneous device into the port opens the port.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
