In various aspects, integrated specimen collection and analyte extraction devices are provided herein. For example, in accordance with various aspects of the present teachings. a device for extracting analytes from a specimen is provided, the device comprising a housing (12) defining an extraction chamber (14) for containing a known volume of a liquid specimen and having an inlet (16) for receiving the liquid specimen. A stationary phase (20) is configured to be disposed within the extraction chamber (14) in contact with the liquid sample so as to adsorb one or more analyte species thereto, wherein at least one of the stationary phase (20) and the one or more analytes adsorbed thereto within the extraction chamber (14) is removable from the extraction chamber (14) for analysis by a chemical analyzer.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
Methods and systems for mass analysis are disclosed herein. An example system includes: a sample ejector configured to eject a plurality of samples from a plurality of wells of a well plate; a capture probe configured to capture the ejected samples and dilute and transport the captured samples; a nebulizer nozzle configured to receive and ionize the transported diluted samples to produce sample ions; a mass analysis instrument configured to filter and detect ions of interest from the sample ions; a controller configured to coordinate operations of the sample ejector, the capture probe, the nebulizer nozzle, and the mass analysis instrument; and a data processing system configured to acquire data from the mass analysis instrument and conduct an automatic data processing process.
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
3.
CONVERSATIONAL SERVICES FOR ARTIFICIAL INTELLIGENCE HEALTH SUPPORT
A system provides artificial intelligence health support for people. The system renders specific, targeted treatments for people by using a flow engine and a conversational service to call one or more conversational modules. The treatments for the people may be tracked. The flow engine and/or one or more of the modules may include different instructions to perform for different programs and/or goals that have been configured. The flow engine and/or one or more of the conversational modules may also include instructions to perform when certain features are active (which may be activated when certain programs and/or goals are configured), when data regarding activity for people are received, and so on. Other modules may be dedicated to particular programs and/or goals. Some modules may determine whether or not to perform various instructions repetitiously, and/or may determine to do so when a priority of a previous instruction is below a threshold.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
A universal power probe fixture (UPPF) that is configured to be installed into a power signal path between a source device and a load device has one or more UPPF base modules, each UPPF base module including an input terminal block, an output terminal block, and a power transfer circuit including a multiple signal lines electrically connected between the input terminal block and the output terminal block, the signal lines structured to convey high power, and each of the signal lines includes a current probe connection point and at least one voltage probe connection point. The UPPF also has a source device connector adapted to electrically connect the source device to the input terminal block, and a load device connector adapted to electrically connect the load device to the output terminal block. A test system using the UPPF, and an application-specific electric vehicle motor probe adapter are also disclosed.
Methods and systems for performing differential mobility spectrometry-mass spectrometry (DMS-MIS) are provided herein. In various aspects, methods and systems described may be effective to improve the performance of a differential mobility spectrometry device and a MS device operating in tandem relative to conventional systems for DMS-MS. In certain aspects, methods and systems in accordance with the present teachings utilize an ion guide which comprises a multipole rod set and a plurality of auxiliary electrodes to which a DC voltage is applied during transmission of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide to accelerate the ions toward the outlet end of the ion guide. This may significantly reduce a pause duration between the application of different compensation voltage values without substantially increasing the likelihood of contamination or cross-talk between groups of ions transmitted by the differential mobility spectrometry device at each compensation voltage value.
A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G01N 15/1433 - Signal processing using image recognition
G06V 10/14 - Optical characteristics of the device performing the acquisition or on the illumination arrangements
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
A filter housing having a hollow filter housing body having a housing inlet/outlet portion having an inlet port and an outlet port, and defining a fluid flow path between the inlet port and the outlet port, wherein the filter housing body comprises at least three layers, is provided. The hollow filter housing body comprises at least three layers: a first layer comprising perfluoroalkoxy alkane (PF A), a second layer comprising a thermoplastic elastomer, and a third layer comprising a thermoplastic.
A system and method for preparing a spillover matrix for a flow cytometry experiment. One or more fluorochrome beads are combined with a sample of biological particles, each of the one or more fluorochrome beads including a discrete fluorochrome. A fluid stream of the combined fluorochrome beads and biological particles is directed through an interrogation location. Light is directed by a laser toward the interrogation location to produce light signals from the combined beads and biological particles. The light signals are converted to waveform data via one or more detectors, and an event is identified from the waveform data associated with the one or more fluorochrome beads. Values associated with the event are measured, and the spillover matrix is generated based on the values.
In one aspect, a time-of-flight (TOF) mass analyzer is disclosed, which includes an inlet for receiving ions, a first ion acceleration region in which at least a portion of the received ions is accelerated to a first energy, a first field-free ion drift region positioned downstream of the first ion acceleration region for receiving the accelerated ions, a second ion acceleration region positioned downstream of the first field-free ion drift region for receiving ions exiting the first field-free ion drift region and accelerating the ions to a second energy, a second field-free ion drift region positioned downstream of the second ion acceleration region for receiving the ions exiting the second ion acceleration region, and an ion detector for receiving ions passing through the second field-free ion drift region and generating ion detection data. The ion detection data can be analyzed to generate a mass spectrum of the detected ions.
A power vector analyzer to analyze power from a device under test (DUT) includes one or more channels to measure a reference voltage signal from a power line connected to the DUT, one or more channels to measure a reference current signal from the power line, a user interface comprising a display and one or more controls, and a quadrature synchronous detector (QSD) for each phase of apparent power being measured, the QSD configured to use a reference voltage signal from the one or more channels and a reference current signal from the one or more channels to determine the apparent power for each phase of power being measured by the DUT and display the apparent power for each phase on the display.
G01R 31/319 - Tester hardware, i.e. output processing circuits
G01R 27/28 - Measuring attenuation, gain, phase shift, or derived characteristics of electric four-pole networks, i.e. two-port networksMeasuring transient response
G01R 35/00 - Testing or calibrating of apparatus covered by the other groups of this subclass
One embodiment of the invention is directed to a method comprising receiving instruction data relating to a sample in a sample container. The method includes generating, by at least one processor using a workflow management layer, a process plan for the sample, and providing the process plan to a process control layer. The process plan comprises a plurality of possible routes. The method also comprises selecting, by the at least one processor using the process control layer, an optimized route within the plurality of possible routes in the process plan, and providing the optimized route to a middleware control layer. The at least one processor and middleware control layer are operable to cause a transport system to proceed along the selected route.
A method of inhibiting corrosion of at least one metal surface that contacts water and/or steam in a water system. The method includes treating the water with a corrosion inhibitor composition including an aqueous dispersion of alkyl bis amide so that the alkyl bis amide forms a protective film on at least a portion of the metal surface.
A drill bit and method for normalizing bone is provided. The drill bit has a non-round drill bit core that is adapted to cut hard bone and to not cut soft bone. The drill bit has a cutting edge which may be positioned within a compression zone of the non-round drill bit core. The rotational speed of the drill bit and the profile of the drill bit core are tuned so that hard bone recovers into a cutting zone defined by the cutting edge while soft bone remains outside of the cutting zone. The insertion torque of the drill bit can be measured to determine when the normalization is adequate.
A system for applying RF voltages to a multipole ion processing device, configured for use in a mass spectrometer, includes a first RF generator configured to generate a first RF voltage and apply to a first pole electrode set, a second RF generator configured to generate a second RF voltage and apply to a second pole electrode set, a first amplitude adjustor configured to adjust an amplitude of the first RF voltage, a second amplitude adjustor configure to adjust an amplitude of the second RF voltage, and a phase adjustor in communication with the first RF generator and the second RF generator to adjust phase output of at least one of the first RF generator and the second RF generator so as to adjust a phase differential between the first RF voltage and the second RF voltage to be within a desired range.
A method of inhibiting corrosion of at least one metal surface that contacts water and/or steam in a water system. The method includes treating the water with a corrosion inhibitor composition including an aqueous dispersion of alkyl bis amide so that the alkyl bis amide forms a protective film on at least a portion of the metal surface.
C23F 11/08 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids
Methods and systems for automatically analyzing a collection of samples, the method including ionizing a plurality of samples, capturing a plurality of raw mass spectra for the ionized plurality of samples, correlating captured respective subsets of the raw mass spectra to each sample of the plurality of samples, and for each sample of the plurality of samples, generating a reconstructed mass spectrum based on the respective subset of the raw mass spectra of the sample. Methods and systems also include correlating the captured respective subsets of the raw mass spectra to each sample by generating a chronogram, and correlating a timeline of a sampling of the sample with the chronogram to correlate the captured respective subsets of the raw mass spectra to each sample. Methods and systems also include analyzing the generated reconstructed mass spectrum for each sample of the plurality of samples.
This invention pertains to optimized protein fusion linkers for creating multi-functional chimeric proteins and methods of using the same. Additionally, the invention pertains to chimeric proteins for use in guided endonuclease systems and methods of using the same.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
A method of performing a flow cytometry experiment includes determining a volume of sample held in a container prior to streaming the sample through an interrogation location. The method includes monitoring the volume of the sample held in the container while running the flow cytometry experiment. The method includes determining whether the volume of the sample held in the container satisfies a threshold volume for performing the flow cytometry experiment, and generating an alert when the volume of the sample held in the container does not satisfy the threshold volume for performing the flow cytometry experiment.
Disclosed in the present invention are an image stitching method and apparatus, an image processing method, and a readable storage medium. The image stitching method comprises: according to a preset arrangement sequence, performing row arrangement and column arrangement of a plurality of unit images to be stitched; determining one of a row arrangement direction and a column arrangement direction as a first direction, and the other one as a second direction; determining seams between adjacent images among the plurality of unit images in the first direction, and stitching adjacent unit images according to the seams, so as to obtain a plurality of intermediate images; and determining seams between adjacent images among the plurality of intermediate images in the second direction, and stitching adjacent intermediate images according to the seams, so as to obtain a result image. In the present invention, images are stitched in two-dimensional directions by means of generating a seam network, thereby avoiding the problems such as artifacts, misalignments, overlapping and blank spaces that are generated during image stitching.
An analytical instrument produces intensity versus time measurements or intensity versus m/z measurements for each acquisition of n acquisitions using m instrument parameter values for each acquisition of n acquisitions, wherein n is a number greater than or equal to two and m is a number equal to or greater than one. For each acquisition of the n acquisitions, the instrument stores a data file that includes m one or more instrument parameter values applied to the instrument, producing n data files. A first data file of the n data files for a first acquisition is retrieved. A next data file of the n data files of a next acquisition is retrieved. The m corresponding parameter values of the first data file and the next data file are compared. If any corresponding parameter values differ between the first data file and the next data file, a notification of an instrument parameter difference corresponding to a name of the next data file is displayed.
In one aspect, a method for fragmenting ions in a mass spectrometer is disclosed, which includes introducing a plurality of precursor ions into a collision cell of a mass spectrometer, generating a potential barrier in the collision cell to cause at least a portion of ions in the collision cell to be trapped within a region in proximity of said potential barrier, and applying ultraviolet (UV) radiation to said trapped ions so as to cause fragmentation of at least a portion of any of said precursor ions and fragment ions thereof to generate a plurality of product ions such that a space charge generated in said region in proximity of said potential barrier due to accumulation of ions will impart sufficient kinetic energy to at least a portion of the product ions so as to overcome said potential barrier, thereby exiting said region.
Aspects relate to a method, a data processing system, a laboratory instrument, a computer program and a computer-readable medium. The method comprises obtaining, by a computing device, a relational result for a first clinical test. The first clinical test is carried out on a biological sample by a first laboratory instrument, the biological sample being in a sample container. The relational result comprises first information and second information, the first information specifying that a laboratory result for the first clinical test is outside a reliability range for the first clinical test carried out by the first laboratory instrument and the second information specifying one or more of an upper bound and a lower bound of the reliability range. The method further comprises assessing, by the computing device, whether a condition of a laboratory rule is determinable by using the first information and the second information. The laboratory rule specifies one or more actions that are to be taken depending on the outcome of a determination of the condition. At least one action of the one or more actions is to be taken on one or more of the biological sample, the sample container and the relational result and/or the one or more actions comprise displaying information about one or more of the biological sample, the sample container, the relational result and a patient. If the condition is determinable and, according to the outcome of the determination of the condition, the one or more actions are to be taken, the method comprises causing, by the computing device, the one or more actions to be taken.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
A microscope stand (102) comprises a base (110) having an observation position (114) configured to receive an object (108) and a microscope column (116) extending in a vertical direction (V) from the base (110). An imaging unit carrier (118) is moveably mounted to the microscope column (116) and configured to mount an imaging unit (104) to the microscope stand (102). The imaging unit (104) is configured to generate a microscopic image of the object (108) received in the observation position (114). The microscope column (116) further comprises a coarse drive (302) which is configured to coarsely adjust the vertical position of the imaging unit carrier (118) along the vertical direction (V), and a fine drive (304) mechanically coupled to the coarse drive (302) and arranged in series with the coarse drive (302). The fine drive (304) is configured to finely adjust the vertical position of the imaging unit carrier (118) along the vertical direction (V). The coarse drive (302) is arranged and configured to be moveable by the fine drive (304), and the fine drive (304) is configured to move the coarse drive (302) and the imaging unit carrier (118) along the vertical direction (V) in order to finely adjust the vertical position of the imaging unit carrier (118).
Mean corpuscular parameter values for a sample, such as a mean corpuscular hemoglobin or mean corpuscular volume for the red blood cells in a sample, can be calculated based on individual cell corpuscular parameter values for the red blood cells in the sample. These values may be obtained using a machine learning algorithm. Such a machine learning algorithm may be trained using sets of training images annotated with transducer derived mean corpuscular parameter values, thereby allowing a flow imaging based analyzer to provide parameter values which may otherwise not be available with that type of analysis tool.
A method for treating water to remove sulfate from the water, when the sulfate is present in the water in an amount of at least 500 ppm, the method including combining a calcium precipitant and an aluminum precipitant together with the water, reacting the calcium precipitant and the aluminum precipitant with the sulfate in the water to form sulfate precipitates, and removing the sulfate precipitates from the water to provide purified water.
The first aspect of this disclosure is related to a computer-based method for measurement of a plurality of optical foci, comprising the steps: measuring a first focus; obtaining one or both of: a) a focus range for a measurement of a second focus, wherein the focus range is based on the first focus; b) a starting value for a measurement of a second focus, wherein the starting value is based on the first focus; measuring the second focus with the obtained focus range and/or staring value; discarding the second focus, if the second focus is measured as an extreme value of the focus range; measuring a third focus.
Methods for treating a water system to prevent scaling. The water system includes water that is prone to scaling and that is processed to remove an organic contaminant with a GAC system and/or an IX system. Antiscalant compositions can be selected to reduce the amount of antiscalant that is adsorbed or otherwise removed in the contaminant removal system so that a sufficient amount of antiscalant composition remains in the water stream.
A method for treating water to remove sulfate from the water, when the sulfate is present in the water in an amount of at least 500 ppm, the method including combining a calcium precipitant and an aluminum precipitant together with the water, reacting the calcium precipitant and the aluminum precipitant with the sulfate in the water to form sulfate precipitates, and removing the sulfate precipitates from the water to provide purified water.
Methods for treating a water system to prevent scaling. The water system includes water that is prone to scaling and that is processed to remove an organic contaminant with a GAC system and/or an IX system. Antiscalant compositions can be selected to reduce the amount of antiscalant that is adsorbed or otherwise removed in the contaminant removal system so that a sufficient amount of antiscalant composition remains in the water stream.
C02F 5/14 - Treatment of water with complexing chemicals or other solubilising agents for softening, scale prevention or scale removal, e.g. adding sequestering agents using organic substances containing phosphorus
Described herein are methods for determining the number of unique sequence molecules, such as copy number variants and breakpoints, in Anchored Multiplex PCR (AMP) panels using only sequencing data from the sample of interest.
Methods of treating aqueous systems with treatment compositions including non-triazole compounds are provided that are effective to inhibit corrosion of corrodible metal surfaces in the aqueous systems. The non-triazole compounds show comparable or better corrosion inhibition as compared to conventional triazole corrosion inhibitors, and have low toxicity and good stability in the presence of halogens such as halogen-containing biocides or free chlorine.
C23F 11/18 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using inorganic inhibitors
The invention refers to a process water sampling immersion probe (10) comprising a filter module (20) comprising a plane filter screen (22, 23) and a sample suction opening (28) through which filtered sample water is pumped from the filter module (20) to an analyzer unit (80), and a rigid holding structure (90) for holding the filter module (20), wherein a swivel bearing arrangement (30) is provided, the swivel bearing arrangement (30) defining a static swivel axis (R) and connecting the filter module (20) with the rigid holding structure (90), so that the filter module (20) can swivel within a swivel sector (S) having a swivel angle of at least 10°.
A needle for use with a biopsy device includes a cannula and a tissue piercing tip. The cannula defines a cutter lumen configured to receive a cutter of the biopsy device and a lateral lumen proximate the cutter lumen. The tissue piercing tip includes a body defining a plurality of cutting surfaces, a lower opening, and an upper opening. At least the upper opening being defined by a single cutting surface of the plurality of cutting surfaces. The upper opening is in communication with the cutter lumen. The lower opening is in communication with the lateral lumen.
A61B 10/02 - Instruments for taking cell samples or for biopsy
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
37.
HETEROCYCLIC NON-TRIAZOLE COMPOUNDS AND METHODS FOR INHIBITING CORROSION IN INDUSTRIAL WATER TREATMENT
Methods of treating aqueous systems with treatment compositions including non-triazole compounds are provided that are effective to inhibit corrosion of corrodible metal surfaces in the aqueous systems. The non-triazole compounds show comparable or better corrosion inhibition as compared to conventional triazole corrosion inhibitors, and have low toxicity and good stability in the presence of halogens such as halogen-containing biocides or free chlorine.
C23F 11/18 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using inorganic inhibitors
38.
S. PYOGENES CAS9 MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME
This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.
A positioning device for an imaging device includes a base element having a first opening, a first circle element arranged rotatably in the first opening and having a second opening, and a second circle element arranged rotatably in the second opening and having a third opening. A center of rotation of the second circle element is eccentric with respect to a center of rotation of the first circle element. The positioning device further includes a third circle element arranged rotatably in the third opening. A center of rotation of the third circle element is eccentric with respect to the center of rotation of the second circle element. The third circle element has a fourth opening configured to receive a sample carrier.
A color measurement device for determining color characteristics of a measurement area (300) is disclosed, comprising a light detector (200) and an optical system (100) for guiding light from the measurement area to the light detector. The optical system (100) defines a system axis (S) that passes through a detection area (210) of the light detector (200). The optical system comprises a first reflective surface (110) that causes incident light rays (Rin) that have entered the optical system parallel to the system axis (S) to be reflected into once-reflected light rays (R1) having a first direction of reflection towards the system axis (S). The optical system further comprises a second reflective surface (120) that causes the once-reflected light rays to be reflected into twice-reflected light rays (R2). The twice-reflected light rays are propagated to the light detector. Advantageously, the optical system comprises an optical body (101) made of a transparent material, wherein the reflective surfaces are formed by surface portions of the optical body, internal reflection taking place at these surface portions.
The present disclosure relates to systems and methods for analyzing particles within a flow cytometry system. A method for analyzing particles within a whole blood sample includes receiving a whole blood sample. Furthermore, the method includes receiving a panel selection relating to one or more constituents within the whole blood sample, wherein the one or more constituents include one or more desired constituents. Furthermore, the method includes adding at least one labeling reagent to the whole blood sample, wherein the at least one labeling reagent is configured to label the one or more desired constituents. Further yet, the method includes collecting flow cytometry data from the whole blood sample and analyzing the one or more constituents.
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
The invention relates to a process water sampling immersion probe (10) comprising a filter module (20) comprising a filter screen (24, 24') and a cleaning air generator (40) arranged vertically adjacent to the vertical lower end (d24) of the filter screen (24, 24'), wherein the cleaning air generator (40) comprises a bubble generator housing (41) with an air exit opening (51, 52) having a non-horizontal opening plane (p54), wherein the air exit opening (51, 52) widens vertically downwardly so that the air exit opening top width (wt54) at the openings top end (t54) is smaller than the air exit opening down width (wd54) at the openings lower end (d54).
Described herein are methods for determining the number of unique sequence molecules, such as copy number variants and breakpoints, in Anchored Multiplex PCR (AMP) panels using only sequencing data from the sample of interest.
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
A biopsy system includes a biopsy device, a control module, and a tissue transport tube. The biopsy device includes a probe, a needle, and a cutter. The needle extends distally from the probe. The cutter is movable relative to the needle to sever one or more tissue samples. The control module is in communication with the biopsy device and includes a sample tray configured to receive one or more tissue samples severed by the cutter. The tissue transport tube is adapted to connect between the tissue sample holder and the cutter of the biopsy device. The sample tray has a sampling configuration and an imaging configuration. The sample tray is configured to move between a sampling axis corresponding to the sapling configuration and an imaging axis corresponding to the imaging configuration to receive and subsequently image one or more tissue samples received within the sample tray.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
A biopsy system includes a biopsy device, a tissue transport tube, and a tissue sample holder. The biopsy device includes a probe, a needle, and a cutter. The needle extends distally from the probe. The cutter is movable relative to the needle to sever one or more tissue samples. The tissue transport tube is configured to couple to a portion of the biopsy device to communicate the one or more severed tissue samples from the biopsy device. The tissue sample holder is separate from the biopsy device and is configured to couple to the tissue transport tube to receive the one or more severed tissue samples. The tissue sample holder incudes a sample tray and an analysis assembly. The sample tray is configured to receive the one or more severed tissue samples. The sample tray has a fixed spatial relationship with respect to the analysis assembly.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
A biopsy system includes a biopsy device, a tissue handler, and a tissue transport tube. The biopsy device includes a probe, a needle, and a cutter. The cutter is movable relative to the needle to sever one or more tissue samples. The tissue handler includes a tissue sample holder and an analysis assembly. The tissue sample holder includes a sample tray including a plurality of sample chambers. The sample tray further includes an external surface defining one or more sample stopping features and a plurality of receiving openings. Each receiving opening corresponds to a sample chamber. The tissue transport tube is adapted to connect between the tissue sample holder and the cutter of the biopsy device. The sample tray is configured to move relative to the tissue transport tube to selectively align the one or more sample stopping features or each receiving opening with the tissue transport tube.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
47.
SYSTEMS AND METHODS FOR GENERATING TRAINING DATA, FOR TRAINING AND APPLICATION OF MACHINE LEARNING ALGORITHMS FOR IMAGES
The present invention essentially relates to a system (150) comprising one or more processors (152) and one or more storage devices (154), for generating training data for training of a machine-learning algorithm, wherein the system is configured to: receive a fluorescence image (129, 129') of an object (112, 162), wherein the fluorescence image (129, 129') has been obtained using a surgical imaging system (100); generate an amplified fluorescence image (132, 132'), based on the fluorescence image (128); generate an image pair (134), the image pair comprising the fluorescence image (129, 129') and the amplified fluorescence image (132, 132'); and provide the image pair (134) for training of a machine-learning algorithm, wherein the machine-learning algorithm is to be trained for use with said or another surgical imaging system.
The present invention essential relates to a controller (150) for a surgical imaging system (100), wherein the surgical imaging system is configured to perform two imaging modes, the two imaging modes comprising a white light imaging mode (120) and a fluorescence imaging mode (126), wherein, in the white light imaging mode, the surgical imaging system is configured to acquire white light images (122) of an object (112), and wherein, in the fluorescence imaging mode (126), the surgical imaging system is configured to acquire fluorescence images (128) of the object (112), wherein the controller (150) is configured to: control the surgical imaging system (100) to perform one of the two imaging modes, and receive the images (122, 128) acquired in said one of the two imaging modes; control the surgical imaging system (100), upon provision of a switching command (124), to perform an imaging mode switch, comprising switching from the one to another of the two imaging modes; control the surgical imaging system (100) to perform said another one of the two imaging modes, and receive the images (122, 128) acquired in said another one of the two imaging modes; generate, when an imaging mode switch is performed, an image pair, the image pair (134) comprising a white light image acquired in the imaging mode before the switch and a fluorescence image acquired in the imaging mode after the switch; and provide the image pair (130) for training of a machine-learning algorithm.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Reagents for medical purposes; Diagnostic reagents for medical use; Diagnostic kit comprised of reagents for medical use; Reagents for use in flow cytometry, for medical purposes; Reagents for preparing and enumerating white blood cells in leukocyte-reduced red blood cells and platelets, for medical purposes.
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Software. Advertising and marketing; Marketing; Online advertisements; Advertising; Advertising, promotional and public relations services. Entertainment services.
51.
SYSTEMS AND METHODS FOR DESIGNING AND MANUFACTURING AN ORTHODONTIC APPLIANCE
Systems and methods of defining a trimline in relation to modeled teeth including modeled gingiva. The trimline is for use to manufacture an aligner. A margin point is placed proximate a gingival margin at each tooth on at least one jaw in the model. A trimline connects the plurality of margin points from which machine code is generated. The aligner manufactured includes an edge that correlates with the trimline according to the machine code. A margin point may be proximate a gingival zenith. At least one tooth cooperates with the modeled gingiva to define a line around the tooth. The trimline includes at least one tooth curve and at least one connector curve connected to the tooth curve at a transition point. At least one control point is on the trimline between two margin points. The trimline is defined by a spline that may be a Bèzier curve.
Embodiment of the present invention relate to a continuous inkjet ink composition which uses a higher order ketone solvent or solvents (ketones having 5 or more carbon atoms) in place or more hazardous solvents such as methyl ethyl ketone and a secondary solvent with a higher derived no effect inhalation level greater than 200 mg/m3 such as ethanol. These ink compositions contain a combination of resins including a cellulose resin and a polyurethane resin or an acrylic resin, with an optional third resin. A colorant (i.e., a dye, preferably a conductive dye) also is included.
The present disclosure provides novel dihydrophenanthrene (DHP) bridged small molecule fluorescent dye compounds. The DHP bridged dye compounds can be excited and/or exhibit emission in UV, violet, blue, yellow, green, red, and near infrared (NIR) wavelengths. Tandem dyes and kits comprising the DHP bridged compounds, are also provided. The dye compounds and tandem dyes may be conjugated to antibodies for detection of target analytes in biological samples and are suitable for use in flow cytometry and other analyses. An exemplary compound has formula 20 below: (I).
A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample with a target protein, generating a second image of the biological sample with a target nucleic acid sequence, and generating a composite image that provides the relative locations of both the target protein and the target nucleic acid sequence. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are systems and kits that comprise the means for executing the novel methods.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A system for characterizing a light beam includes a detector that includes at least one detector unit, and a micro-opto-electromechanical system that includes an array of mirrors. Each mirror is switchable between a first sand a second witching states. In the first switching state, the mirror reflects light emitted by a light source onto the detector. In the second switching state, the mirror reflects the light away from the detector. The system further includes a controller configured to cause a beam profile measurement to be performed on the light detected by the detector unit while selectively switching the mirrors between the first and the second switching states, and an optical unit configured to direct the light in a form of two different input light beams onto the micro-opto-electromechanical system. The controller is configured to cause the beam profile measurement to be performed on each of the two input light beams.
A test and measurement instrument includes one or more ports to allow the test and measurement instrument to receive a signal from a device under test (DUT), a user interface to allow the user to send inputs to the test and measurement instrument and receive results, and one or more processors configured to acquire the signal from the DUT, make measurements on the signal to create a decimated measurement set, convert the decimated measurement set into a tensor, send the tensor to a machine learning network, and receive a pass/fail value from the machine learning network. A method includes acquiring a signal from a device under test (DUT), making measurements on the signal to create a decimated measurement set, convert the decimated measurement set into a tensor, sending the tensor to a machine learning network, and receiving a pass/fail value from the machine learning network.
In one aspect, a method of operating an analytical device for measuring at least one analyte within a sample is disclosed, which includes utilizing a digital data processor to receive a sample acquisition rate for introduction of the sample into the analytical device, and to compute one or more optimal operating parameters of the analytical device based on the sample acquisition rate by optimizing a figure-of-merit associated with measurement of the analyte, where the operating parameters include a temporal duration of a measurement cycle and/or selectivity associated with the measurement. The analytical device can be operated at the optimal operating parameters while receiving the sample at the sample acquisition rate to generate sample measurement data corresponding to the analyte. The sample measurement data can be processed to derive information about the analyte.
A laser microdissection system (100, 200) comprises a stage (110) configured to receive a sample (104) to be cut and a collection unit (108) comprising at least one well (106) arranged below the sample (104), the well (106) being arranged and configured to capture a dissectate (102) cut from the sample (104). The laser dissection system further comprises an objective nosepiece (112) mounting two or more objectives (114a, 114b, 204) that can be alternately pivoted into the optical axis (O) of the laser microdissection system (100, 200) for at least cutting and/or observing the sample (104). At least one of the objectives (114a, 114b, 204) is configured as a long working distance objective (114a, 204) having a working distance (WD) greater than or equal to the depth of the well (106) with a depth of at least 11.2 mm and at most 42 mm, and is configured such that the other objectives (114b) mounted by the objective nosepiece (112) do not collide with the sample (104), the collection unit (108) and/or the stage (110), when a bottom of the well (106) is in focus of the long working distance objective (114a, 204).
A computer-implemented method for installing software on an analyzer apparatus configured to operate in a first or second mode, wherein the first mode is associated with a cold start-up of the analyzer apparatus and the second mode is associated with a warm start-up of the analyzer apparatus, and wherein the analyzer apparatus accommodates one or more sensor device and consumables. The method comprises the steps of obtaining a software installer image comprising a set of software components to be installed on the analyzer apparatus, determining whether the analyzer apparatus is to start-up in the first or second mode, and when the analyzer apparatus is to start-up in the first mode: installing the obtained software installer image comprising the set of software components on the analyzer apparatus, starting-up the analyzer apparatus in the first mode, and when the analyzer apparatus is to start-up in the second mode: obtaining data related to a state of the analyzer apparatus, storing the obtained data in a storage device, installing the obtained software installer image comprising the set of software components on the analyzer apparatus, re-applying the state of the analyzer apparatus based on the obtained data stored in the storage device, and starting-up the analyzer apparatus in the second mode.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
Methods for orthodontic treatment planning include modifying a digital picture of a patient based on a tooth model produced during simulated orthodontic treatment after movement of at least one model tooth to produce a modified digital image depicting the at least one model tooth after movement. The method includes matching and morphing information from the digital picture into the modified digital image. Modifying includes matching a model tooth in the T1 model to a tooth in the digital picture and morphing that information into the modified digital image. Morphing may include projecting a model tooth in the T1 model to an image plane of the digital picture and projecting a model tooth from an intermediate T model to the image plane. Parameterization of the projections of each model may be used to develop a pixel correspondence map, which is usable during rendering of a tooth in the modified digital image.
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G06F 18/22 - Matching criteria, e.g. proximity measures
G06T 11/60 - Editing figures and textCombining figures or text
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
G06V 20/20 - ScenesScene-specific elements in augmented reality scenes
G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
65.
IMAGING TECHNIQUES TO DETERMINE BLOOD CELL CHARACTERISTICS
Cell analysis methods may include, and cell analysis systems may be configured to support, flowing blood cells from a sample through a flow cell, capturing images of the cells as they flow through the flow cell, and then processing them based on execution of instructions stored on a non- transitory computer readable medium. This processing may include determining a plurality of cell paramctcr values for each cell image, and, for each of the cell images, determining a morphology score for that image based on that image's plurality of cell parameter values.
DATA PROCESSING DEVICE AND COMPUTER-IMPLEMENTED METHOD FOR DISPLAYING BLOOD OXYGENATION AND CONCENTRATION VALUES IN A MEDICAL OBSERVATION DEVICE AND MEDICAL OBSERVATION DEVICE AND METHOD FOR ITS USE
A data processing device (170) is configured to access at least one digital input image (130), representative of a reflected-light image of a biological object (106) and comprising a plurality of input pixels (230, 232). A blood concentration value is determined at an input pixel (230, 232) of the plurality of input pixels (230, 232), the blood concentration value representing the amount of blood at a location of the object (106), which location is imaged in the input pixel (230, 232). Further, a blood oxygenation value is determined at the input pixel (230, 232), the blood oxygenation value representing the amount of deoxyhemoglobin and/or oxyhemoglobin at the location of the object (106). Output pixels (230, 234) of a digital output color image (160) are generated by assigning a color (222) to each output pixel (230, 234), the color (222) depending on the blood oxygenation value and the blood concentration value.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
67.
DATA PROCESSING DEVICE, MEDICAL OBSERVATION APPARATUS AND METHOD
The present invention relates to a data processing device (300) for a medical observation apparatus, such as an endoscope, microscope or any other type of medical imaging device. The data processing device is configured to obtain (110) input image data (115), the input image data representing a scene acquired by the medical observation apparatus, to analyze (120) the input image data to determine different categories (125) in the scene, to generate (130) a plurality of stereoscopic images (135) from the input image data (115), each one of the stereoscopic images representing a different category (125) determined in the scene, to assign (140), based on the determined categories, a different disparity to each of the plurality of stereoscopic images to produce a plurality of processed stereoscopic images (145) and to combine (150) the plurality of processed stereoscopic images (145) to generate a combined stereoscopic image (155). Advantageously, the data processing device (300) enables stereoscopic visualization, even though it does not necessarily require the input image data (115) to derive from an apparatus compatible with stereoscopic imaging. The invention also relates to a medical observation apparatus (304) with such a data processing device (300). Further, the invention relates to a computer-implemented method (100) as well as a computer-readable medium and a computer program product.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
68.
APPARATUS, OPTICAL IMAGING SYSTEM, METHOD AND COMPUTER PROGRAM
Examples provide an apparatus (130) for an optical imaging system. The apparatus (130) comprises one or more processors (134) and one or more storage devices (136). The apparatus (130) is configured to obtain sample position data indicative of a position of the microscope relative to a sample. Further, the apparatus (130) is configured to obtain position data indicative of a position of a microscope of the optical imaging system relative to the user of the optical imaging system. The apparatus (130) is further configured to determine deviation angle data indicative of a deviation of a viewing path of the user on the sample and a viewing path of the microscope on the sample in an image plane of the optical imaging system. The deviation angle data is determined based on the position data and the sample position data. Further, the apparatus (130) is configured to determine output data for informing the user about the deviation of the viewing path of the user on the sample and the viewing path of the microscope on the sample. The output data is determined based on the deviation angle data. The apparatus (130) is further configured to transmit a display signal indicative of the output data.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
G06F 16/50 - Information retrievalDatabase structures thereforFile system structures therefor of still image data
G06F 18/22 - Matching criteria, e.g. proximity measures
G06F 18/40 - Software arrangements specially adapted for pattern recognition, e.g. user interfaces or toolboxes therefor
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
The present disclosure relates to a damper for a surgical imaging device and a surgical imaging device. The damper is comprising a stack of layers comprising: a first outer layer, a central layer, and a second outer layer. The layers are linked to form a base piece of the damper. The first outer layer further forms a first end of the damper configured to be connected to a stand of the surgical imaging device and the second outer layer further forms a second end of the damper configured to be connected to a base of the surgical imaging device. The damper is configured to undergo elastic deformation in response to a pushing or pulling force exhibited on one of the ends such that the central layer, but not the outer layers, undergo elastic deformation. Application of the force to the first end causes a deferral of the first outer layer relative to the second outer layer, thereby inducing shearing deformation of the central layer.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
71.
SOLUTION FOR A CT DENTAL X-RAY IMAGING OF AN OBJECT
The invention relates to a dental X-ray imaging system for a computed tomography (CT) dental X-ray imaging of an object. The system comprises: a dental X-ray imaging unit comprising: an X-ray source part, an X-ray imaging detector part, and a gantry part; and a control system. The control system is configured to: receive scan request comprising an indication of at least one region of interest (ROI); control the parts of the dental X-ray imaging unit to acquire two X-ray scout images of the object; detect at least one target structure of the object from the two X-ray scout images associated with the at least one ROI by applying at least one trained detection model for the X-ray scout images; define field of view (FOV) data of the dental X-ray imaging unit at least partially based on the detected at least one target structure; and control the parts of the dental X-ray imaging unit to implement the defined FOV data for a CT scan the object (300) in order to acquire dental CT X-ray image data of the object. The invention relates also to a method for a computed tomography (CT) dental X-ray imaging, a computer program and a tangible non-volatile computer-readable medium.
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61B 6/46 - Arrangements for interfacing with the operator or the patient
A61B 6/51 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications for dentistry
72.
METHODS AND DEVICES FOR PROCESSING BIOLOGICAL SAMPLES IN A LABORATORY AUTOMATION SYSTEM
Summarising the invention, a computer-implemented method is provided. The method comprises obtaining a first route plan as processing route plan for processing a sample container within an automated laboratory system, wherein: the sample container contains a biological sample on which a first clinical test is to be carried out; the automated laboratory system comprises a first laboratory instrument configured to carry out the first clinical test; determining that the first laboratory instrument is unavailable to carry out the first clinical test; determining that processing of the sample container according to the first route plan is affected by the unavailability of the first laboratory instrument; once a predetermined waiting time period has elapsed, checking whether the first laboratory instrument is still unavailable to carry out the first clinical test; if the first laboratory instrument is still unavailable to carry out the first clinical test, obtaining a second route plan different from the first route plan and setting the second route plan as the processing route plan.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
73.
LABORATORY AUTOMATION SYSTEM PROCESSING OF FOLLOW UP TESTS
A laboratory automation system may perform tests on a biological sample. This may include performing a first test on a first testing portion contained in a first container. After the first test has been performed, the laboratory automation system may obtain an order to perform a follow up test, and may then make a container determination comprising determining a container from which a second testing portion should be extracted. Following this container determination, the follow up test may be performed on the second testing portion.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
74.
USING TRAINED MACHINE LEARNING MODELS TO DETERMINE ALIGNMENT CHARACTERISTICS
Computer implemented methods for flow cell analysis may include, and cell analysis systems may be configured to support, flowing blood cells from a sample through a flow cell, capturing images of the cells as they flow through the flow cell, and then determining an alignment characteristic score based on the plurality of cell images using a trained machine learning model.
Methods and systems for controlling a filament of an electron emitter associated with an ion reaction cell in accordance with various aspects of the present teachings may account for inter-filament and inter-instrument variability and can provide improved reproducibility in EAD experiments and ease of use. In some aspects, a method of operating an ion reaction device of a mass spectrometer system is provided. The method comprises applying a calibration drive voltage to a filament of an electron emitter associated with an ion reaction cell and determining a value representative of the calibration electron emission current generated by the filament while having the calibration drive voltage applied thereto. A calibration saturation voltage can be determined by iteratively increasing the calibration drive voltage applied to the filament and determining the value of the calibration electron emission current at each corresponding calibration drive voltage until the filament reaches a saturation condition.
The present invention is directed to methods and compositions for adding tails of specific lengths to a substrate polynucleotide. The invention also contemplates methods and compositions for immobilization of tailed substrates to a solid support. The disclosure contemplates that the attenuator molecule is any biomolecule that associates with a tail sequence added to a substrate polynucleotide and controls the addition of a tail sequence to the 3′ end of the substrate polynucleotide. The sequence that is added to the substrate polynucleotide is referred to herein as a tail sequence, or simply a tail, and the process of adding a nucleotide to a substrate polynucleotide is referred to herein as tailing.
A capture construct for capturing a plurality of analytes of a biological sample includes a nanostructure backbone, at least a first orientation indicator and a second orientation indicator, and at least a first plurality of capture regions on the nanostructure backbone. Each capture region includes at least one affinity capture reagent configured to capture one of the plurality of analytes.
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
The present disclosure relates to a dental implant comprising a core body having an apical end, a coronal end, and an outer surface. The core body extends along a longitudinal axis between said apical end and said coronal end. The dental implant further includes a first thread extending from the outer surface of the core body, the first thread being formed at least partially along the core body. The first thread comprises an apical thread end, a coronal thread end, and a front face at the apical thread end. The front face comprises at least one cutting edge.
Methods and systems for analyzing a sample that includes a protein and a binding ligand, the method including receiving the sample at an ionization device via non-contact sampling, the first sample being in a non-denaturing carrier solvent, ionizing the first sample, generating a deconvoluted mass spectrum for the ionized first sample, and detecting binding between the protein and the binding ligand in the first sample based at least in part on the deconvoluted mass spectrum. The non-contact sampling is performed via a non-contact sample ejector. Methods and systems for analyzing a sample that includes a protein includes receiving the sample via non-contact sampling, the sample being in one of a plurality of non-denaturing carrier solvents, and for non-denaturing carrier solvent, ionizing the sample, generating a deconvoluted mass spectrum for the ionized sample, and detecting protein binding in the first sample based at least in part on the deconvoluted mass spectrum.
H01J 49/00 - Particle spectrometers or separator tubes
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
85.
RAPIDLY-SEDIMENTING MAGNETIC PARTICLES AND APPLICATIONS THEREOF
According to various aspects of the instant disclosure, a rapidly-sedimenting magnetic particle can include a core or inner layer. The core or inner layer can include a ferrimagnetic material and have at least one of a maximum field strength ranging from about 20 emu/g to about 250 emu/g, and a remanence ranging from about 0 cmu/g to about 20 emu/g. The rapidly-sedimenting magnetic particle can further include a coating layer overlaying at least a portion of the core or inner layer. The particle can further include an outer coating layer overlaying at least a portion of the core coating.
In one aspect, a heat transfer structure for use in a mass spectrometer can include a collar for surrounding a plurality of rods arranged in a multipole configuration, at least one ceramic pad positioned to be in thermal contact with at least one of the rods, and at least one thermally conductive plate positioned to provide a heat transfer path between the at least one ceramic pad and the collar. The heat transfer structure can further include a bracket mounted on a bracket mounting portion of the collar for transferring heat from the collar to a rail.
Examples relate to a head-mounted display system, to a surgical microscope comprising a head-mounted display system, and to a corresponding method and computer program. The head-mounted display system comprises one or more displays, one or more storage devices and a control system. The control system is configured to receive an image stream from an external device. The control system is configured to record the image stream using the one or more storage devices upon request of a user of the head-mounted display system. The control system is configured to generate a display signal based on the image stream. The control system is configured to provide the display signal to the one or more displays.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/20 - Surgical microscopes characterised by non-optical aspects
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
A marker for analysing a biological sample includes an affinity reagent with a backbone and a barcode oligonucleotide attached to the backbone. The backbone is configured to specifically bind to a target analyte. The marker further includes a label comprising a label oligonucleotide and at least one labelling moiety. The label oligonucleotide and the barcode oligonucleotide of the affinity reagent are configured to hybridise to each other. One of the label oligonucleotide and the barcode oligonucleotide is sensitive to a degradation agent. The other one of the label oligonucleotide and the barcode oligonucleotide is resistant to the degradation agent.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
89.
AFFINITY REAGENT, MARKER AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
An affinity reagent for analysing a biological sample includes a backbone, and a barcode oligonucleotide attached to the backbone. The backbone includes a first nucleic acid analogue. The backbone is configured to specifically bind to a target analyte by a complex structure thereof. The barcode oligonucleotide includes a second nucleic acid analogue.
A system for analyzing particles includes a flow chamber that streams the particles through an interrogation zone. A light emitting unit generates an excitation light beam directed toward the interrogation zone causing forward scattered light from the particles passing through the interrogation zone. A collection unit collects the forward scattered light, and includes a beam splitter conveying a first portion of the forward scattered light in a first direction and a second portion of the forward scattered light in a second direction, a first detector detecting the first portion of the forward scattered light, and a second detector detecting the second portion of the forward scattered light. The system generates waveforms from the second portion of the forward scattered light, determines one or more parameters from the waveforms, and discriminates the particles based on at least one of shape and morphology using the one or more parameters.
Systems, apparatus, and computer-readable storage media are disclosed for analyzing samples of a well plate. Systems may include a well plate, a mass spectrometer, and a computing device. The well plate may include rows of wells. The mass spectrometer may sequentially capture a sample from each well of the rows of wells and generate spectral data that includes mass spectrum data for each captured sample. The computing device may receive the spectral data generated by the mass spectrometer, detect rows of spectral data in the spectral data, wherein each row of spectral data corresponds to a row of wells in the well plate; and generate a spectral data matrix from the detected rows of spectral data such that each row of wells comprises a corresponding row of spectral data in the spectral data matrix.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
92.
AFFINITY REAGENT, MARKER AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
An affinity reagent for analysing a biological sample includes a nucleic acid backbone, and a barcode oligonucleotide attached to the nucleic acid backbone. The nucleic acid backbone is configured to specifically bind to a target analyte by a complex structure thereof. The nucleic acid backbone is configured to maintain the complex structure in presence of the barcode oligonucleotide.
The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
The disclosure relates to a vessel unit (2000) comprising a vessel (2200), a vessel connection part (2100) and a vessel closure (2300), the vessel connection part (2100) being connected to the vessel (2200) by the vessel closure (2300), the vessel connection part (2100) comprising a vessel connection part body (2130), a vessel pressure medium channel (2120) for pressure medium and a vessel pressure medium channel (2110) for pressure medium, a vessel mounting medium channel (2110) for the mounting medium, and a vessel pressure medium channel (2120) for a pressure medium, wherein the vessel unit (2000) is adapted to dispense mounting medium via the vessel mounting medium channel (2110) when pressure medium is supplied via the vessel pressure medium channel (2120). The disclosure further relates to an assembly comprising the vessel unit and an automatic coverslipper for automatically applying the coverslipping medium from the vessel unit and a coverslip to a slide.
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
B65D 43/00 - Lids or covers for rigid or semi-rigid containers
B65D 47/06 - Closures with discharging devices other than pumps with pouring spouts or tubesClosures with discharging devices other than pumps with discharge nozzles or passages
B65D 51/18 - Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
A computer-implemented method of modifying a texture image (T) representing a texture of a coating is disclosed. The texture image comprises a plurality of pixels (P), each pixel having a pixel value (TP(x)) in a color space and being associated with a surface position (x1, x2) on a surface (11) of the coating. The method comprises, for at least one pixel (P) in the texture image, the steps of defining a depth at which a virtual reflecting object is located below the surface of the coating at the surface position; for at least one component of the color space, determining an attenuation factor (A2(l, ō,x)) for light that has entered the coating through the surface as incident light and has been reflected at the virtual reflecting object to form reflected light, based on a simulation of light transport through the coating along said light path; and modifying the pixel value of the pixel to obtain a modified pixel value (TP′(x)), using the attenuation factor.
A solvent delivery system for an open port interface (OPI) includes a first diverter which includes a wash solvent inlet, a carrier solvent inlet, and a first diverter outlet. A wash solvent pump is fluidically coupled to the wash solvent inlet. A carrier solvent pump is fluidically coupled to the carrier solvent inlet. A second diverter includes a second diverter inlet fluidically coupled to the first diverter outlet. An OPI port is configured to be coupled to an OPI. A waste outlet is configured to be coupled to a waste container.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
98.
METHODS AND SYSTEMS FOR GENERATING A CONTROLLABLE AXIAL PSEUDOPOTENTIAL BARRIER IN MULTIPOLE ROD SETS OF MASS SPECTROMETERS
The present teachings are generally related to generating a pseudo potential barrier via an axial RF field. As discussed herein in more detail, such a pseudo potential barrier can be employed in a variety of different applications. By way of example, such a pseudo potential barrier can be employed for trapping ions within a rod set comprising a plurality of rods arranged in a multipole configuration. In other applications, an adjustment of the height of the pseudo potential barrier established in a rod set together with application of a DC potential between the rod set and an external electrode can be utilized to cause mass selective extraction of ions trapped within the rod set. In yet other applications, such a pseudo potential barrier can be employed in multiplexing approaches for performing mass spectrometry.
The present teachings are generally related to a method of performing mass spectrometry, which includes dissociating a plurality of precursor ions to generate a first set of product ions, wherein ions with approximately same m/z are associated in a group, and wherein said first set of product ions contains at least two groups of ions with distinct m/z's. The method further includes introducing the first set of product ions into an ion trap; transferring different groups of the first set of product ions during different time intervals from the ion trap to an ion dissociation device so as to cause dissociation of at least a portion of the first set of product ions to generate a second set of product ions, and acquiring a mass spectrum of the second set of product ions.
