Systems and methods of defining a trimline in relation to modeled teeth including modeled gingiva. The trimline is for use to manufacture an aligner. A margin point is placed proximate a gingival margin at each tooth on at least one jaw in the model. A trimline connects the plurality of margin points from which machine code is generated. The aligner manufactured includes an edge that correlates with the trimline according to the machine code. A margin point may be proximate a gingival zenith. At least one tooth cooperates with the modeled gingiva to define a line around the tooth. The trimline includes at least one tooth curve and at least one connector curve connected to the tooth curve at a transition point. At least one control point is on the trimline between two margin points. The trimline is defined by a spline that may be a Bèzier curve.
Embodiment of the present invention relate to a continuous inkjet ink composition which uses a higher order ketone solvent or solvents (ketones having 5 or more carbon atoms) in place or more hazardous solvents such as methyl ethyl ketone and a secondary solvent with a higher derived no effect inhalation level greater than 200 mg/m3 such as ethanol. These ink compositions contain a combination of resins including a cellulose resin and a polyurethane resin or an acrylic resin, with an optional third resin. A colorant (i.e., a dye, preferably a conductive dye) also is included.
The present disclosure provides novel dihydrophenanthrene (DHP) bridged small molecule fluorescent dye compounds. The DHP bridged dye compounds can be excited and/or exhibit emission in UV, violet, blue, yellow, green, red, and near infrared (NIR) wavelengths. Tandem dyes and kits comprising the DHP bridged compounds, are also provided. The dye compounds and tandem dyes may be conjugated to antibodies for detection of target analytes in biological samples and are suitable for use in flow cytometry and other analyses. An exemplary compound has formula 20 below: (I).
A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample with a target protein, generating a second image of the biological sample with a target nucleic acid sequence, and generating a composite image that provides the relative locations of both the target protein and the target nucleic acid sequence. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are systems and kits that comprise the means for executing the novel methods.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A system for characterizing a light beam includes a detector that includes at least one detector unit, and a micro-opto-electromechanical system that includes an array of mirrors. Each mirror is switchable between a first sand a second witching states. In the first switching state, the mirror reflects light emitted by a light source onto the detector. In the second switching state, the mirror reflects the light away from the detector. The system further includes a controller configured to cause a beam profile measurement to be performed on the light detected by the detector unit while selectively switching the mirrors between the first and the second switching states, and an optical unit configured to direct the light in a form of two different input light beams onto the micro-opto-electromechanical system. The controller is configured to cause the beam profile measurement to be performed on each of the two input light beams.
A test and measurement instrument includes one or more ports to allow the test and measurement instrument to receive a signal from a device under test (DUT), a user interface to allow the user to send inputs to the test and measurement instrument and receive results, and one or more processors configured to acquire the signal from the DUT, make measurements on the signal to create a decimated measurement set, convert the decimated measurement set into a tensor, send the tensor to a machine learning network, and receive a pass/fail value from the machine learning network. A method includes acquiring a signal from a device under test (DUT), making measurements on the signal to create a decimated measurement set, convert the decimated measurement set into a tensor, sending the tensor to a machine learning network, and receiving a pass/fail value from the machine learning network.
In one aspect, a method of operating an analytical device for measuring at least one analyte within a sample is disclosed, which includes utilizing a digital data processor to receive a sample acquisition rate for introduction of the sample into the analytical device, and to compute one or more optimal operating parameters of the analytical device based on the sample acquisition rate by optimizing a figure-of-merit associated with measurement of the analyte, where the operating parameters include a temporal duration of a measurement cycle and/or selectivity associated with the measurement. The analytical device can be operated at the optimal operating parameters while receiving the sample at the sample acquisition rate to generate sample measurement data corresponding to the analyte. The sample measurement data can be processed to derive information about the analyte.
A laser microdissection system (100, 200) comprises a stage (110) configured to receive a sample (104) to be cut and a collection unit (108) comprising at least one well (106) arranged below the sample (104), the well (106) being arranged and configured to capture a dissectate (102) cut from the sample (104). The laser dissection system further comprises an objective nosepiece (112) mounting two or more objectives (114a, 114b, 204) that can be alternately pivoted into the optical axis (O) of the laser microdissection system (100, 200) for at least cutting and/or observing the sample (104). At least one of the objectives (114a, 114b, 204) is configured as a long working distance objective (114a, 204) having a working distance (WD) greater than or equal to the depth of the well (106) with a depth of at least 11.2 mm and at most 42 mm, and is configured such that the other objectives (114b) mounted by the objective nosepiece (112) do not collide with the sample (104), the collection unit (108) and/or the stage (110), when a bottom of the well (106) is in focus of the long working distance objective (114a, 204).
A computer-implemented method for installing software on an analyzer apparatus configured to operate in a first or second mode, wherein the first mode is associated with a cold start-up of the analyzer apparatus and the second mode is associated with a warm start-up of the analyzer apparatus, and wherein the analyzer apparatus accommodates one or more sensor device and consumables. The method comprises the steps of obtaining a software installer image comprising a set of software components to be installed on the analyzer apparatus, determining whether the analyzer apparatus is to start-up in the first or second mode, and when the analyzer apparatus is to start-up in the first mode: installing the obtained software installer image comprising the set of software components on the analyzer apparatus, starting-up the analyzer apparatus in the first mode, and when the analyzer apparatus is to start-up in the second mode: obtaining data related to a state of the analyzer apparatus, storing the obtained data in a storage device, installing the obtained software installer image comprising the set of software components on the analyzer apparatus, re-applying the state of the analyzer apparatus based on the obtained data stored in the storage device, and starting-up the analyzer apparatus in the second mode.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
Methods for orthodontic treatment planning include modifying a digital picture of a patient based on a tooth model produced during simulated orthodontic treatment after movement of at least one model tooth to produce a modified digital image depicting the at least one model tooth after movement. The method includes matching and morphing information from the digital picture into the modified digital image. Modifying includes matching a model tooth in the T1 model to a tooth in the digital picture and morphing that information into the modified digital image. Morphing may include projecting a model tooth in the T1 model to an image plane of the digital picture and projecting a model tooth from an intermediate T model to the image plane. Parameterization of the projections of each model may be used to develop a pixel correspondence map, which is usable during rendering of a tooth in the modified digital image.
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G06F 18/22 - Matching criteria, e.g. proximity measures
G06T 11/60 - Editing figures and textCombining figures or text
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
G06V 20/20 - ScenesScene-specific elements in augmented reality scenes
G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
13.
IMAGING TECHNIQUES TO DETERMINE BLOOD CELL CHARACTERISTICS
Cell analysis methods may include, and cell analysis systems may be configured to support, flowing blood cells from a sample through a flow cell, capturing images of the cells as they flow through the flow cell, and then processing them based on execution of instructions stored on a non- transitory computer readable medium. This processing may include determining a plurality of cell paramctcr values for each cell image, and, for each of the cell images, determining a morphology score for that image based on that image's plurality of cell parameter values.
DATA PROCESSING DEVICE AND COMPUTER-IMPLEMENTED METHOD FOR DISPLAYING BLOOD OXYGENATION AND CONCENTRATION VALUES IN A MEDICAL OBSERVATION DEVICE AND MEDICAL OBSERVATION DEVICE AND METHOD FOR ITS USE
A data processing device (170) is configured to access at least one digital input image (130), representative of a reflected-light image of a biological object (106) and comprising a plurality of input pixels (230, 232). A blood concentration value is determined at an input pixel (230, 232) of the plurality of input pixels (230, 232), the blood concentration value representing the amount of blood at a location of the object (106), which location is imaged in the input pixel (230, 232). Further, a blood oxygenation value is determined at the input pixel (230, 232), the blood oxygenation value representing the amount of deoxyhemoglobin and/or oxyhemoglobin at the location of the object (106). Output pixels (230, 234) of a digital output color image (160) are generated by assigning a color (222) to each output pixel (230, 234), the color (222) depending on the blood oxygenation value and the blood concentration value.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
15.
DATA PROCESSING DEVICE, MEDICAL OBSERVATION APPARATUS AND METHOD
The present invention relates to a data processing device (300) for a medical observation apparatus, such as an endoscope, microscope or any other type of medical imaging device. The data processing device is configured to obtain (110) input image data (115), the input image data representing a scene acquired by the medical observation apparatus, to analyze (120) the input image data to determine different categories (125) in the scene, to generate (130) a plurality of stereoscopic images (135) from the input image data (115), each one of the stereoscopic images representing a different category (125) determined in the scene, to assign (140), based on the determined categories, a different disparity to each of the plurality of stereoscopic images to produce a plurality of processed stereoscopic images (145) and to combine (150) the plurality of processed stereoscopic images (145) to generate a combined stereoscopic image (155). Advantageously, the data processing device (300) enables stereoscopic visualization, even though it does not necessarily require the input image data (115) to derive from an apparatus compatible with stereoscopic imaging. The invention also relates to a medical observation apparatus (304) with such a data processing device (300). Further, the invention relates to a computer-implemented method (100) as well as a computer-readable medium and a computer program product.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
16.
APPARATUS, OPTICAL IMAGING SYSTEM, METHOD AND COMPUTER PROGRAM
Examples provide an apparatus (130) for an optical imaging system. The apparatus (130) comprises one or more processors (134) and one or more storage devices (136). The apparatus (130) is configured to obtain sample position data indicative of a position of the microscope relative to a sample. Further, the apparatus (130) is configured to obtain position data indicative of a position of a microscope of the optical imaging system relative to the user of the optical imaging system. The apparatus (130) is further configured to determine deviation angle data indicative of a deviation of a viewing path of the user on the sample and a viewing path of the microscope on the sample in an image plane of the optical imaging system. The deviation angle data is determined based on the position data and the sample position data. Further, the apparatus (130) is configured to determine output data for informing the user about the deviation of the viewing path of the user on the sample and the viewing path of the microscope on the sample. The output data is determined based on the deviation angle data. The apparatus (130) is further configured to transmit a display signal indicative of the output data.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
G06F 16/50 - Information retrievalDatabase structures thereforFile system structures therefor of still image data
G06F 18/22 - Matching criteria, e.g. proximity measures
G06F 18/40 - Software arrangements specially adapted for pattern recognition, e.g. user interfaces or toolboxes therefor
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
The present disclosure relates to a damper for a surgical imaging device and a surgical imaging device. The damper is comprising a stack of layers comprising: a first outer layer, a central layer, and a second outer layer. The layers are linked to form a base piece of the damper. The first outer layer further forms a first end of the damper configured to be connected to a stand of the surgical imaging device and the second outer layer further forms a second end of the damper configured to be connected to a base of the surgical imaging device. The damper is configured to undergo elastic deformation in response to a pushing or pulling force exhibited on one of the ends such that the central layer, but not the outer layers, undergo elastic deformation. Application of the force to the first end causes a deferral of the first outer layer relative to the second outer layer, thereby inducing shearing deformation of the central layer.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
19.
SOLUTION FOR A CT DENTAL X-RAY IMAGING OF AN OBJECT
The invention relates to a dental X-ray imaging system for a computed tomography (CT) dental X-ray imaging of an object. The system comprises: a dental X-ray imaging unit comprising: an X-ray source part, an X-ray imaging detector part, and a gantry part; and a control system. The control system is configured to: receive scan request comprising an indication of at least one region of interest (ROI); control the parts of the dental X-ray imaging unit to acquire two X-ray scout images of the object; detect at least one target structure of the object from the two X-ray scout images associated with the at least one ROI by applying at least one trained detection model for the X-ray scout images; define field of view (FOV) data of the dental X-ray imaging unit at least partially based on the detected at least one target structure; and control the parts of the dental X-ray imaging unit to implement the defined FOV data for a CT scan the object (300) in order to acquire dental CT X-ray image data of the object. The invention relates also to a method for a computed tomography (CT) dental X-ray imaging, a computer program and a tangible non-volatile computer-readable medium.
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61B 6/46 - Arrangements for interfacing with the operator or the patient
A61B 6/51 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications for dentistry
20.
METHODS AND DEVICES FOR PROCESSING BIOLOGICAL SAMPLES IN A LABORATORY AUTOMATION SYSTEM
Summarising the invention, a computer-implemented method is provided. The method comprises obtaining a first route plan as processing route plan for processing a sample container within an automated laboratory system, wherein: the sample container contains a biological sample on which a first clinical test is to be carried out; the automated laboratory system comprises a first laboratory instrument configured to carry out the first clinical test; determining that the first laboratory instrument is unavailable to carry out the first clinical test; determining that processing of the sample container according to the first route plan is affected by the unavailability of the first laboratory instrument; once a predetermined waiting time period has elapsed, checking whether the first laboratory instrument is still unavailable to carry out the first clinical test; if the first laboratory instrument is still unavailable to carry out the first clinical test, obtaining a second route plan different from the first route plan and setting the second route plan as the processing route plan.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
21.
LABORATORY AUTOMATION SYSTEM PROCESSING OF FOLLOW UP TESTS
A laboratory automation system may perform tests on a biological sample. This may include performing a first test on a first testing portion contained in a first container. After the first test has been performed, the laboratory automation system may obtain an order to perform a follow up test, and may then make a container determination comprising determining a container from which a second testing portion should be extracted. Following this container determination, the follow up test may be performed on the second testing portion.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
22.
USING TRAINED MACHINE LEARNING MODELS TO DETERMINE ALIGNMENT CHARACTERISTICS
Computer implemented methods for flow cell analysis may include, and cell analysis systems may be configured to support, flowing blood cells from a sample through a flow cell, capturing images of the cells as they flow through the flow cell, and then determining an alignment characteristic score based on the plurality of cell images using a trained machine learning model.
Methods and systems for controlling a filament of an electron emitter associated with an ion reaction cell in accordance with various aspects of the present teachings may account for inter-filament and inter-instrument variability and can provide improved reproducibility in EAD experiments and ease of use. In some aspects, a method of operating an ion reaction device of a mass spectrometer system is provided. The method comprises applying a calibration drive voltage to a filament of an electron emitter associated with an ion reaction cell and determining a value representative of the calibration electron emission current generated by the filament while having the calibration drive voltage applied thereto. A calibration saturation voltage can be determined by iteratively increasing the calibration drive voltage applied to the filament and determining the value of the calibration electron emission current at each corresponding calibration drive voltage until the filament reaches a saturation condition.
The present invention is directed to methods and compositions for adding tails of specific lengths to a substrate polynucleotide. The invention also contemplates methods and compositions for immobilization of tailed substrates to a solid support. The disclosure contemplates that the attenuator molecule is any biomolecule that associates with a tail sequence added to a substrate polynucleotide and controls the addition of a tail sequence to the 3′ end of the substrate polynucleotide. The sequence that is added to the substrate polynucleotide is referred to herein as a tail sequence, or simply a tail, and the process of adding a nucleotide to a substrate polynucleotide is referred to herein as tailing.
A capture construct for capturing a plurality of analytes of a biological sample includes a nanostructure backbone, at least a first orientation indicator and a second orientation indicator, and at least a first plurality of capture regions on the nanostructure backbone. Each capture region includes at least one affinity capture reagent configured to capture one of the plurality of analytes.
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
The present disclosure relates to a dental implant comprising a core body having an apical end, a coronal end, and an outer surface. The core body extends along a longitudinal axis between said apical end and said coronal end. The dental implant further includes a first thread extending from the outer surface of the core body, the first thread being formed at least partially along the core body. The first thread comprises an apical thread end, a coronal thread end, and a front face at the apical thread end. The front face comprises at least one cutting edge.
Methods and systems for analyzing a sample that includes a protein and a binding ligand, the method including receiving the sample at an ionization device via non-contact sampling, the first sample being in a non-denaturing carrier solvent, ionizing the first sample, generating a deconvoluted mass spectrum for the ionized first sample, and detecting binding between the protein and the binding ligand in the first sample based at least in part on the deconvoluted mass spectrum. The non-contact sampling is performed via a non-contact sample ejector. Methods and systems for analyzing a sample that includes a protein includes receiving the sample via non-contact sampling, the sample being in one of a plurality of non-denaturing carrier solvents, and for non-denaturing carrier solvent, ionizing the sample, generating a deconvoluted mass spectrum for the ionized sample, and detecting protein binding in the first sample based at least in part on the deconvoluted mass spectrum.
H01J 49/00 - Particle spectrometers or separator tubes
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
29.
RAPIDLY-SEDIMENTING MAGNETIC PARTICLES AND APPLICATIONS THEREOF
According to various aspects of the instant disclosure, a rapidly-sedimenting magnetic particle can include a core or inner layer. The core or inner layer can include a ferrimagnetic material and have at least one of a maximum field strength ranging from about 20 emu/g to about 250 emu/g, and a remanence ranging from about 0 cmu/g to about 20 emu/g. The rapidly-sedimenting magnetic particle can further include a coating layer overlaying at least a portion of the core or inner layer. The particle can further include an outer coating layer overlaying at least a portion of the core coating.
In one aspect, a heat transfer structure for use in a mass spectrometer can include a collar for surrounding a plurality of rods arranged in a multipole configuration, at least one ceramic pad positioned to be in thermal contact with at least one of the rods, and at least one thermally conductive plate positioned to provide a heat transfer path between the at least one ceramic pad and the collar. The heat transfer structure can further include a bracket mounted on a bracket mounting portion of the collar for transferring heat from the collar to a rail.
Examples relate to a head-mounted display system, to a surgical microscope comprising a head-mounted display system, and to a corresponding method and computer program. The head-mounted display system comprises one or more displays, one or more storage devices and a control system. The control system is configured to receive an image stream from an external device. The control system is configured to record the image stream using the one or more storage devices upon request of a user of the head-mounted display system. The control system is configured to generate a display signal based on the image stream. The control system is configured to provide the display signal to the one or more displays.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/20 - Surgical microscopes characterised by non-optical aspects
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
A marker for analysing a biological sample includes an affinity reagent with a backbone and a barcode oligonucleotide attached to the backbone. The backbone is configured to specifically bind to a target analyte. The marker further includes a label comprising a label oligonucleotide and at least one labelling moiety. The label oligonucleotide and the barcode oligonucleotide of the affinity reagent are configured to hybridise to each other. One of the label oligonucleotide and the barcode oligonucleotide is sensitive to a degradation agent. The other one of the label oligonucleotide and the barcode oligonucleotide is resistant to the degradation agent.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
33.
AFFINITY REAGENT, MARKER AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
An affinity reagent for analysing a biological sample includes a backbone, and a barcode oligonucleotide attached to the backbone. The backbone includes a first nucleic acid analogue. The backbone is configured to specifically bind to a target analyte by a complex structure thereof. The barcode oligonucleotide includes a second nucleic acid analogue.
A system for analyzing particles includes a flow chamber that streams the particles through an interrogation zone. A light emitting unit generates an excitation light beam directed toward the interrogation zone causing forward scattered light from the particles passing through the interrogation zone. A collection unit collects the forward scattered light, and includes a beam splitter conveying a first portion of the forward scattered light in a first direction and a second portion of the forward scattered light in a second direction, a first detector detecting the first portion of the forward scattered light, and a second detector detecting the second portion of the forward scattered light. The system generates waveforms from the second portion of the forward scattered light, determines one or more parameters from the waveforms, and discriminates the particles based on at least one of shape and morphology using the one or more parameters.
Systems, apparatus, and computer-readable storage media are disclosed for analyzing samples of a well plate. Systems may include a well plate, a mass spectrometer, and a computing device. The well plate may include rows of wells. The mass spectrometer may sequentially capture a sample from each well of the rows of wells and generate spectral data that includes mass spectrum data for each captured sample. The computing device may receive the spectral data generated by the mass spectrometer, detect rows of spectral data in the spectral data, wherein each row of spectral data corresponds to a row of wells in the well plate; and generate a spectral data matrix from the detected rows of spectral data such that each row of wells comprises a corresponding row of spectral data in the spectral data matrix.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
36.
AFFINITY REAGENT, MARKER AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
An affinity reagent for analysing a biological sample includes a nucleic acid backbone, and a barcode oligonucleotide attached to the nucleic acid backbone. The nucleic acid backbone is configured to specifically bind to a target analyte by a complex structure thereof. The nucleic acid backbone is configured to maintain the complex structure in presence of the barcode oligonucleotide.
The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
The disclosure relates to a vessel unit (2000) comprising a vessel (2200), a vessel connection part (2100) and a vessel closure (2300), the vessel connection part (2100) being connected to the vessel (2200) by the vessel closure (2300), the vessel connection part (2100) comprising a vessel connection part body (2130), a vessel pressure medium channel (2120) for pressure medium and a vessel pressure medium channel (2110) for pressure medium, a vessel mounting medium channel (2110) for the mounting medium, and a vessel pressure medium channel (2120) for a pressure medium, wherein the vessel unit (2000) is adapted to dispense mounting medium via the vessel mounting medium channel (2110) when pressure medium is supplied via the vessel pressure medium channel (2120). The disclosure further relates to an assembly comprising the vessel unit and an automatic coverslipper for automatically applying the coverslipping medium from the vessel unit and a coverslip to a slide.
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
B65D 43/00 - Lids or covers for rigid or semi-rigid containers
B65D 47/06 - Closures with discharging devices other than pumps with pouring spouts or tubesClosures with discharging devices other than pumps with discharge nozzles or passages
B65D 51/18 - Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
A computer-implemented method of modifying a texture image (T) representing a texture of a coating is disclosed. The texture image comprises a plurality of pixels (P), each pixel having a pixel value (TP(x)) in a color space and being associated with a surface position (x1, x2) on a surface (11) of the coating. The method comprises, for at least one pixel (P) in the texture image, the steps of defining a depth at which a virtual reflecting object is located below the surface of the coating at the surface position; for at least one component of the color space, determining an attenuation factor (A2(l, ō,x)) for light that has entered the coating through the surface as incident light and has been reflected at the virtual reflecting object to form reflected light, based on a simulation of light transport through the coating along said light path; and modifying the pixel value of the pixel to obtain a modified pixel value (TP′(x)), using the attenuation factor.
A solvent delivery system for an open port interface (OPI) includes a first diverter which includes a wash solvent inlet, a carrier solvent inlet, and a first diverter outlet. A wash solvent pump is fluidically coupled to the wash solvent inlet. A carrier solvent pump is fluidically coupled to the carrier solvent inlet. A second diverter includes a second diverter inlet fluidically coupled to the first diverter outlet. An OPI port is configured to be coupled to an OPI. A waste outlet is configured to be coupled to a waste container.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
42.
METHODS AND SYSTEMS FOR GENERATING A CONTROLLABLE AXIAL PSEUDOPOTENTIAL BARRIER IN MULTIPOLE ROD SETS OF MASS SPECTROMETERS
The present teachings are generally related to generating a pseudo potential barrier via an axial RF field. As discussed herein in more detail, such a pseudo potential barrier can be employed in a variety of different applications. By way of example, such a pseudo potential barrier can be employed for trapping ions within a rod set comprising a plurality of rods arranged in a multipole configuration. In other applications, an adjustment of the height of the pseudo potential barrier established in a rod set together with application of a DC potential between the rod set and an external electrode can be utilized to cause mass selective extraction of ions trapped within the rod set. In yet other applications, such a pseudo potential barrier can be employed in multiplexing approaches for performing mass spectrometry.
The present teachings are generally related to a method of performing mass spectrometry, which includes dissociating a plurality of precursor ions to generate a first set of product ions, wherein ions with approximately same m/z are associated in a group, and wherein said first set of product ions contains at least two groups of ions with distinct m/z's. The method further includes introducing the first set of product ions into an ion trap; transferring different groups of the first set of product ions during different time intervals from the ion trap to an ion dissociation device so as to cause dissociation of at least a portion of the first set of product ions to generate a second set of product ions, and acquiring a mass spectrum of the second set of product ions.
The present disclosure provides a computing device (100) for classification of an aspirating/dispensing operation in an automated analyzer (50). The computing device (100) comprises a memory (22) storing a neural network model (24). The neural network model 24 sequentially comprises a plurality of convolution blocks (202-1, 202-2 . . . 202-N). The computing device (100) further comprises a processor (20) communicably coupled to the memory (22) and at least one measurement sensor (106) associated with a pipetting probe (104) of a pipetting device (102). The processor (20) is capable of executing the neural network model (24). The processor (20) is further capable of executing instructions (26) to classify the aspirating/dispensing operation into at least one correct class or at least one incorrect class.
A tube from a plurality of tubes from a tube rack configured to removably hold the plurality of tubes are removed from a tube rack. A weight of the tube which has been removed from the tube rack is determined. A balancing parameter of the tube is determined by a computing device. An estimated balancing parameter of each of a plurality of remaining tubes from the plurality of tubes in the tube rack is determined. A corresponding rotor position from a plurality of rotor positions within the rotor for the tube is determined by the computing device based at least on the balancing parameter of the tube, the balancing parameters of previously placed tubes from the plurality of tubes placed within the rotor and the estimated balancing parameter of each of the plurality of remaining tubes. The transport unit places the tube in the corresponding rotor position within the rotor.
A method of performing mass spectrometry is disclosed. which comprises introducing a plurality of ions into an ion guide of a mass spectrometer via an inlet orifice thereof. where the ion guide includes a plurality of rods arranged in a multipole configuration and spaced from one another to provide a passageway for transit of the ions therethrough. applying RF voltages to the rods so as to generate an electromagnetic field within the passageway for providing radial confinement of the ions passing through the passageway, identifying a space charge effect, which can adversely affect operation of the mass spectrometer, based on detection of a variation of an intensity of an ion detection signal associated with at least one ion population transmitted through said ion guide and having an m/z ratio greater than a threshold, and in response to said identification of the adverse space charge effect. adjusting at least one of frequency and amplitude of the RF voltages to counteract said space charge effect.
Leak detection systems and methods in accordance with various aspects of the present teachings can, in various embodiments, sequester fluid leaking from the interface between a sample source and the inlet of the ion source, alert an operator as to a leak condition, and/or automatically terminate the experiment. In various aspects, a liquid leak detection system is accordance with the present teachings comprises a collection basin configured to couple to a proximal end of a conduit in fluid communication with a discharge end of an ion source of a mass spectrometer such that the proximal end of the conduit extends through the internal volume of the basin. The system may also comprise a drainage tube having an inlet end opening into an internal volume of the collection basin and configured to drain liquid therefrom, a sensor disposed within the basin or the drainage tube and configured to generate a signal indicative of liquid therewithin, and a processor that is configured to cause a user to be alerted and/or cause an experiment to be terminated upon receiving from the sensor a signal indicative of a leak.
G01M 3/20 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
49.
SYSTEMS AND METHODS FOR ERROR CORRECTION IN FAST SAMPLE READERS
A method and system for detecting a signal measurement error, the method including providing a well plate including error correction wells and sample wells, each sample well including a single sample, and each error correction well including a mixture of samples from two or more sample wells. The method includes receiving an aliquot from the wells at a sample receiver, measuring a signal for the received aliquot, calculating an expected signal for each of the error correction wells, comparing the measured signal to the calculated expected signal for each error correction well, and determining whether an error exists in the signal of at least one sample well. When the error exists, the method correlates the error to one or more sample wells.
A biological fluid analyser is provided, the biological fluid analyser comprising an imaging system comprising a light source assembly configured to emit light; a first lens assembly configured to direct the light from the light source assembly; an aperture device configured to apply an aperture to allow light from the first lens assembly to pass through the aperture in order to indirectly define a probing light; the imaging system defining a probing volume configured to receive the probing light and configured to receive a container comprising a prepared biological fluid sample; the biological fluid analyser comprising a controller configured to control the aperture device according to an aperture configuration, wherein the aperture device, in response to a first aperture control signal, is configured to apply an aperture with a first aperture configuration, and wherein the aperture device, in response to a second aperture control signal, is configured to apply an aperture with a second aperture configuration.
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
Systems and methods implement measuring, in a test and measurement instrument, operational signal timing parameters of electrical signals being communicated over an electrical bus by a device under test. A bus timing characteristics analyzer identifies nominal signal timing parameters for the acquired electrical signals. The nominal signal timing parameters are defined by the bus protocol and defining timing criteria for the electrical signals. The analyzer measures operational signal timing parameters for each of the acquired electrical signals and compares, for each of the electrical signals, the operational signal timing parameters to the nominal signal timing parameters to determine whether the operational signal timing parameters satisfy the timing criteria. The analyzer then displays, on the test and measurement instrument, a visual indication for each of the electrical signals indicating whether the operational signal timing parameters for the electrical signal satisfy the timing criteria.
The probe washstation assembly includes a unitary housing with a first at least one well fluidically connected to a first channel extending through the first at least one well at an inlet region of the housing, a second at least one well fluidically connected to a second channel extending through the second at least one well at the inlet region of the housing, a first inlet fluidically connected to the first channel, a second inlet fluidically connected to the second channel, and a waste pathway configured to direct waste fluid from the first and second at least one well to an outlet. The first and second channels are spaced apart from one another.
Mass spectrometry systems and methods are disclosed. In some embodiments, the mass spectrometry system comprises an ion trap configured to receive a plurality of precursor ions and to load the plurality of precursor ions in a trap region; an electron gun configure to perform an irradiation operation by applying an electron beam to the trap region to produce fragmented ions; an RF gate configured to perform an extraction operation by extracting, from the trap region, a high m/z subset of the fragmented ions with m/z ratios greater than a specific value; and a mass spectrometer configured to perform mass spectrometry analysis on a subset of the fragmented ions remaining in the trap region, wherein an irradiation-extraction operation, including performing the irradiation operation and the extraction operation, is repeated at least twice before performing the mass spectrometry analysis on the subset of the fragmented ions remaining in the trap region.
The present teachings are generally related to generating a pseudo potential barrier via an axial RF field. A first RF voltage is applied to a first pair of rods arranged in a multipole configuration, a second RF voltage is applied to a second pair of rods, and a difference between amplitudes and/or phases of said first RF voltage and said second RF voltage is adjusted. As discussed herein in more detail, such a pseudo potential barrier can be employed in a variety of different applications. By way of example, such a pseudo potential barrier can be employed for trapping ions within a rod set comprising a plurality of rods arranged in a multipole configuration. In other applications, an adjustment of the height of the pseudo potential barrier established in a rod set together with application of a DC potential between the rod set and an external electrode can be utilized to cause mass selective extraction of ions trapped within the rod set. In yet other applications, such a pseudo potential barrier can be employed in multiplexing approaches for performing mass spectrometry.
An optically detectable label (102, 500) is provided comprising a nucleic acid backbone (108, 504) comprising multiple attachment positions (306, 308, 506a, 506b, 506c, 506d) including at least a first attachment position and a second attachment position. The optically detectable label (102, 500) further comprises multiple labelling moieties (106a, 106b, 106c, 106d, 106e, 310, 312, 502a, 502b, 502c, 502d), including at least a first labelling moiety and a second labelling moiety, each labelling moiety (106a, 106b, 106c, 106d, 106e, 310, 312, 502a, 502b, 502c, 502d) attached to a different one of the attachment positions (306, 308, 506a, 506b, 506c, 506d) of the nucleic acid backbone (108, 504). The first labelling moiety and the second labelling moiety are configured to form an energy transfer donor and acceptor pair. Further, the nucleic acid backbone (108, 504) has at least a first spatial state (300, 500a) and a second spatial state (322, 500b), wherein in the first spatial state the attachment position to which the first labelling moiety and the attachment position to which the second labelling moiety are attached to, are in proximity in order to enable an energy transfer between the first labelling moiety and the second labelling moiety. Moreover, the nucleic acid backbone (108, 504) is in the first spatial state (300, 500a) when a first staple strand (302, 510, 512) is bound to the nucleic acid backbone (108, 504). In further aspects, a marker (100) comprising the optically detectable label (102, 500) is provided and a method for analysing a biological sample.
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
G01N 33/532 - Production of labelled immunochemicals
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
A biopsy site marker includes a carrier and a marker element. The carrier is configured to expand in diameter in response to moisture. The marker element includes a base portion. The base portion defines a plurality of interconnected legs. Each leg is configured to move relative to another leg to permit movement of the marker element from a pre-deployment configuration to a post-deployment configuration. The base portion is disposed around an outer surface of the carrier. The carrier is configured to drive movement of the marker element from the pre-deployment configuration to the post-deployment configuration.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Examples relate to a microscope system, such as a surgical microscope system, and to a corresponding method. The microscope system (100) comprises a microscope (120) with a first optical imaging sensor (122) for generating first imaging sensor data based on light having a first wavelength spectrum, a second optical imaging sensor (124) for generating second imaging sensor data based on light having a second wavelength spectrum, and a multispectral iris (130), configured to provide an opening with a first numerical aperture for the light having the first wavelength spectrum and an opening with a second numerical aperture for the light having the second wavelength spectrum, with the first numerical aperture being different from the second numerical aperture. The microscope system comprises one or more processors (114), configured to generate a composite image based on the first imaging sensor data and based on the second imaging sensor data.
There is presented an apparatus for analyzing one or more fluids and comprising an analysis unit for analyzing one or more fluids, such as human blood, a liquid inlet port, and a liquid outlet port, a cartridge comprising a pouch comprising a liquid, such as an aqueous liquid, an absorbing element, wherein the absorbing element is capable of absorbing water, and wherein the absorbing element is arranged exterior to the pouch and fluidically connected to an exterior surface of the pouch, a liquid outlet port being fluidically connected to the pouch, and a liquid inlet port being fluidically connected to the element, wherein the liquid inlet port of the analysis unit is fluidically connected with the liquid outlet port of the cartridge, and the liquid outlet port of the analysis unit is fluidically connected with the liquid inlet port of the cartridge.
An oscilloscope includes input channels for receiving at least one voltage signal and at least one current signal from at least one component of a photovoltaic power system under test (SUT), a user interface including a display and one or more controls for receiving one or more test configuration settings from a user, and one or more processors configured to acquire waveforms of the at least one voltage signal and the at least one current signal, and implement a photovoltaic power system compliance test module that automatically determines, in real-time, one or more SUT performance measurements based on the acquired voltage and current waveforms and the one or more test configuration settings, displays, in real-time, the one or more SUT performance measurements to the user on the display. Methods of performing automated hardware-in-the-loop testing of a photovoltaic power system under test using an oscilloscope are also disclosed.
A method for identifying a replacement industrial printer comprises receiving, by a processor, data associated with an industrial printer; determining, by the processor, an issue associated with the industrial printer based on the data; identifying, by the processor, the replacement industrial printer from a plurality of replacement industrial printers, the identifying based on one or more criteria.
Aspects relate to a laboratory automation system, a computer-implemented method, and a computer program for processing sample containers. The laboratory automation system comprises a storage unit configured to receive and store sample containers. The laboratory automation system further comprises at least one laboratory instrument configured to process samples contained in the sample containers. The laboratory automation system further comprises a conveying unit configured to convey sample containers between the storage unit and the laboratory instrument. The storage unit comprises a pick-and-place unit, a working section, a storing section, and a transfer unit. The working section is configured such that a plurality of sample containers may be arranged therein to be accessible by the pick-and-place unit. The pick-and-place unit is configured to pick up a sample container in the working section and to place said sample container on the conveying unit. The storing section is configured such that a plurality of sample containers may be arranged therein by a user, and the transfer unit is configured to transfer the sample containers between the working section and the storing section.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The present disclosure relates to a surgical imaging device, a surgical imaging system and a method for ventilation of a surgical imaging device. The surgical imaging device comprises an image acquisition apparatus carrier, an arm, a stand, and a ventilation system. The ventilation system comprises an air intake, a fan, a flow path, and an exhaust part. The ventilation system is configured to generate an air flow inside the surgical imaging device. The fan is positioned within the flow path configured to create a directed air flow along the flow path from the air intake to the exhaust part. An intake port of the air intake is positioned at a first end of the arm. The exhaust part is positioned in the stand. The flow path extends from the intake port though the arm and the stand to the exhaust part.
Examples relate to a system (110), method, and computer program for an ophthalmic microscope system, and to a corresponding ophthalmic microscope system. The system is configured to obtain imaging sensor data from an optical imaging sensor (122) of a microscope of the ophthalmic microscope system. The system is configured to determine information on an anatomical feature of an eye shown in the imaging sensor data. The system is configured to control an illumination system (130) of the ophthalmic microscope system to adjust a property of a light beam used for red reflex illumination of the eye based on the information on the anatomical feature.
A61B 3/14 - Arrangements specially adapted for eye photography
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
66.
NOVEL FORMULATION FOR DRYING OF POLYMER DYE CONJUGATED ANTIBODIES
A novel dry down buffer is provided for use in drying a plurality of fluorescent dye conjugates on a substrate for use in flow cytometry. The aqueous buffer comprises a water-soluble monomer; a protein stabilizer; a carbohydrate stabilizer; and a zwitterionic surfactant. When mixed with a multi-color panel comprising fluorescent polymer dye conjugates, dried on a substrate, and reconstituted with a biological sample, the buffer provides decreased aggregation of fluorescent polymer dye conjugates, and decreased non-specific binding of monocytes and granulocytes, when compared to use of a buffer without the water-soluble monomer or zwitterionic surfactant.
In a method for controlling a centrifuge (100) comprising a rotor (106) and a drive component (104) for the rotor (106), an acoustic signal (AS) is received, at a computing device (102), via a sound transducer (108) located proximate to the rotor (106) of the centrifuge (100). The acoustic signal (AS) is pre-processed, by the computing device (102), by emphasizing at least one predetermined signal feature of the acoustic signal (AS), the signal feature indicating an abnormal operation of the centrifuge (100). An abnormal operation of the centrifuge (100) is detected, by the computing device (102), by processing the emphasized signal feature. An alarm signal and/or a termination signal (212) is generated, by the computing device (102), if an abnormal operation of the centrifuge (100) is detected.
Described herein are methods and compositions for improved hybridization capture for enriching for target nucleic acid sequences from a population of nucleic acids. In one aspect, the methods and compositions are useful for Next Generation Sequencing (NGS) applications. The methods and compositions include combining in solution capture probes and target nucleic acid and permitting hybridization of the target nucleic acid to the capture probes under conditions to promote efficient hybridization. Following hybridization, the probe/target complex is immobilized to a capture material while simultaneously incubating at an optimum hybridization temperature. The incubation denatures unwanted nucleic acids from the capture probes further enriching for target nucleic acid.
Examples relate to an optical imaging system (100), such as a microscope system (100), and to a corresponding method. The optical imaging system (100) comprises an optical imaging component (120) with (124), the optical imaging component being suitable for imaging an object (10). The optical imaging system (100) comprises an illumination system (130) for emitting light having a polarization towards the object. The optical imaging system (100) comprises a polarization filter (140) configured to block light having the polarization from arriving at the first optical imaging sensor. The optical imaging system (100) comprises a processing system (110) being configured to obtain first imaging sensor data from the first optical imaging sensor and second imaging sensor data from the second optical imaging sensor, and generate a composite view based on the first imaging sensor data and based on the second imaging sensor data.
A method for analysing a biological sample that includes multiple targets is provided. The method includes staining the targets of the biological sample with multiple detectable markers, providing affinity information specifying an affinity of each marker towards at least some of the targets, generating a readout of the biological sample with the markers to generate raw readout data, and unmixing the raw readout data by applying an unmixing algorithm and the affinity information to generate unmixed readout data with respect to the targets.
A sample carrier (1) is configured to transport a sample along a track (120) of a sample transport system (100). The sample carrier (1) comprises a sample transport section (10) configured to hold and transport the sample, a conductive section (20), and a magnetic section (30). The magnetic section (30) is configured to induce an eddy current in an adjacent conductive section (20) of another element of the sample transport system (100) when there is a relative movement between the sample carrier (1) and this other element. The conductive section (20) is configured to experience eddy current induced by a magnetic section (30) of another element of the sample transport system (100) when there is a relative movement between the sample carrier (1) and this other element.
The presently claimed and described technology provides methods for analyzing an encapsulated biomolecule by loading the encapsulated biomolecule on a capillary electrophoresis (CE) capillary, wherein the CE capillary is filled with a buffer comprising a polymer matrix; applying a voltage to the CE capillary to release the biomolecule from the encapsulating material; and detecting the biomolecule released from the encapsulating material. Kits for analyzing an encapsulated biomolecule are also disclosed.
A connector assembly that includes an electrical connector having a connector conductor, a connector housing, a PCB substrate bonded to a base, positioning pads extending away from the PCB substrate, and metallic bumps extending away from the PCB substrate. The connector housing has a housing conductor that is electrically connected to the connector conductor. The PCB substrate is brittle, and the housing conductor contacts an electrical signal path on the PCB substrate at an oblique angle. The positioning pads keep the mounting face of the connector housing away from the PCB substrate at a standoff distance. The metallic bumps are malleable and configured to provide an electrical connection between the PCB substrate and the mounting face of the connector housing.
H01R 43/18 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for manufacturing bases or cases for contact members
74.
VALIDATION OF DISPLAYS FOR DISPLAYING REFERENCE COLORS
A method for scoring color accuracy of color output devices relative to a set of discrete color standards comprises causing a color output device to generate a plurality of discrete colors; measuring the generated plurality of discrete colors; for each color measurement, determining color differences between the color measurement and corresponding reference spectral or colorimetric information for the discrete color standards; scoring the color output device based on weighted scores for color precision, average color difference between a generated discrete color and its corresponding target color, and highest individual color difference between a generated discrete color and its corresponding target color; and for each generated color, determining a closest matching discrete standard color by identifying the discrete standard color having the lowest color difference from the generated color's measurement.
The presently claimed and described technology is directed to electrophoretic methods for conditioning a capillary using a conditioning buffer including a surface active polymer and a separation reagent including a separation polymer.
DATA PROCESSING DEVICE AND COMPUTER-IMPLEMENTED METHOD FOR COMBINING A FLUORESCENCE EMISSION SIGNAL WITH AN EDGE DETECTION SIGNAL IN A MEDICAL OBSERVATION DEVICE
The invention relates to a data processing device (170) and a computer-implemented method for a medical observation device (100), such as a microscope or an endoscope, for observing an object (106) which contains a fluorophore (116, 118).The data processing device (170) is configured: to access input image data (120) representative of an image of the object (106), the input image data containing a reflectance signal (202), the reflectance signal being representative of light (198) reflected off the object, and a fluorescence emission signal (204), the fluorescence emission signal being representative of fluorescence emitted by the object; to apply an edge detection routine (148) to the reflectance signal (202) to generate an edge detection signal (600); and to generate a digital output image (160) from a combination of the edge detection signal and the fluorescence emission signal.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
77.
DATA PROCESSING DEVICE AND COMPUTER IMPLEMENTED INVENTION FOR A MEDICAL OBSERVATION DEVICE, FOR VISUALIZATION OF AN AUTOFLUORESCENCE SIGNAL AND A FLUORESCENCE EMISSION SIGNAL
The invention relates to a data processing device (170) for a medical observation device (100), such as a microscope or an endoscope, for observing an object (106) The data processing device (170) is configured to access input image data (120). The input image data contain an autofluorescence signal (224), the autofluorescence signal being representative of fluorescence emitted by a fluorophore (116) naturally contained in the object, and a fluorescence emission signal (204), the fluorescence emission signal being representative of fluorescence emitted by a fluorophore (118) artificially added to the object. Finally, the data processing device (170) is configured to generate a digital fluorescence color output image (160) from a combination of the fluorescence emission signal colored in a first color (308) and the autofluorescence signal colored in a second color (310), the second color being different from the first color.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
78.
APPARATUS FOR AN OPTICAL IMAGING SYSTEM, OPTICAL IMAGING SYSTEM, METHOD AND COMPUTER PROGRAM
Examples relate to an apparatus (130) for an optical imaging system comprising one or more processors (134) and one or more storage devices (136). The apparatus is configured to obtain sensor data indicative of a reflectance measurement of a sample (110). The apparatus is further configured to convert the sensor data into reflectance spectral data indicative of a reflectance spectral signal. The reflectance spectral signal is a function of the concentration distribution of the sample. Further, the apparatus is configured to obtain fluorescence spectral data indicative of fluorescence spectral signal of a fluorescence measurement of the sample. The apparatus is further configured to combine the reflectance spectral data and the fluorescence spectral data to combined spectral data. Further, the apparatus is configured to determine the concentration distribution of the sample based on the combined spectral data.
A gas filter element comprising: a first end and a second end, having a plurality of inlet channels and a plurality of slotted outlet channels between the first end and the second end, wherein, in an alternating pattern, the plurality of inlet channels each have an inlet channel opening at the first end, and are closed at the second end, and the plurality of slotted outlet channels each have a slotted outlet channel opening at the second end, and are closed at the first end, each of the plurality of inlet channels being surrounded by 4 slotted outlet channels; each of the plurality of inlet channels and each of the plurality of plurality of slotted outlet channels having an inner cross-sectional area, each of the plurality of inlet channels having an inner cross-sectional area exceeding the inner cross-sectional area of each of the plurality of slotted outlet channels.
F01N 3/022 - Exhaust or silencing apparatus having means for purifying, rendering innocuous, or otherwise treating exhaust for cooling, or for removing solid constituents of, exhaust by means of filters characterised by specially adapted filtering structure, e.g. honeycomb, mesh or fibrous
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Computers; electric and electronic apparatus for laboratory
analysis; scientific apparatus and instruments; measuring
apparatus and instruments; electronic measuring devices;
laboratory analyzers; laboratory analyzers for measuring,
testing and analyzing blood and other bodily fluids;
electronic testing devices for the measurement of biological
materials and taking of biological measurements;
point-of-care electronic testing devices; point-of-care
electronic testing devices for the measurement of biological
materials and taking of biological measurements, namely,
hand-held or portable photometers and analyzers for clinical
and laboratory use; laboratory electronic apparatus;
laboratory electronic apparatus for the measurement
determination of biological materials and taking of
biological measurements, namely, clinical laboratory
analyzers; electronic equipment used for performing biologic
measurements for clinical and laboratory use, namely,
photometers and analyzers; monitoring apparatus and
instruments; remote monitoring apparatus; scientific and
measuring apparatus and instruments for clinical and
laboratory use, namely, monitors, photometers, and analyzers
for the measurement of the levels of different substances
and compounds in bodily fluids; photometers and
spectrophotometers; spectrophotometers and photometers for
providing cell and particle analysis, detection, or counting
for clinical, laboratory, and general research uses;
electronic sensors; electronic measurement sensors;
electronic sensors for measuring liquids, namely, monitors,
photometers, and analyzers for measuring bodily fluids;
testing and quality control devices; quality control
materials for calibration purposes, namely, calibrators for
use in calibrating and verifying the accuracy of photometers
and electronic sensors used for measuring liquids; cuvettes,
microcuvettes, holders for cuvettes and microcuvettes;
laboratory analytical apparatus, namely, cuvettes suitable
for the measurements of the levels of different substances
and compounds in bodily fluids; data and file management
software; database management software; computer software
relating to the medical field; computer software for use in
medical measuring, screening, monitoring, diagnostics and
analysis; health monitoring software; computer software for
the measurement of biological materials and taking of
biological measurements; computer software for the
measurement of biological materials and taking of biological
measurements, namely, biological measurement data management
and biological measurement data analysis software; docking
stations; electronic docking stations; photometers for
providing cell and particle analysis, detection, or counting
for medical, clinical, medical diagnostic, and therapeutic
uses; bodily fluid analyzers for providing cell and particle
analysis, detection, or counting for clinical uses;
instrument and apparatus systems for medical diagnostic uses
consisting of photometers, sample preparation device, and
related data management software sold as a unit; diagnostic
apparatus and instruments for research and laboratory use,
in particular for the measurement of biological materials
and taking of biological measurements, namely, photometers;
instruments for diagnosis [for scientific use]. Medical apparatus and instruments including apparatus for
medical analysis; electronic analyzers for medical purposes;
automatic analyzers for medical diagnosis; automated
analyzers for body fluids [for medical use]; diagnostic
measuring apparatus for medical use; medical apparatus and
instruments for medical analysis for the measurement of
biological materials and taking of biological measurements,
namely, bodily fluid monitors and analyzers; diabetic
monitoring apparatus; apparatus for blood monitoring [for
medical use]; blood testing apparatus and equipment; blood
glucose monitoring apparatus; apparatus for blood tests [for
medical use]; apparatus for blood analysis; hemocytometers;
devices for measuring blood glucose for medical purposes;
blood glucose testing apparatus; blood glucose meters; blood
analyzers and bodily fluid analyzers; bodily fluid analyzers
for providing cell and particle analysis, detection, or
counting for medical, medical diagnostic, and therapeutic
uses; instrument and apparatus systems for medical
diagnostic uses consisting of hematology analyzers, sample
preparation device, and related data management software
sold as a unit; automated blood collection apparatus and
instruments; apparatus for carrying out diagnostic tests for
medical purposes; diagnostic, examination and monitoring
equipment; electric instruments for medical use in the
diagnosis of blood; electronic monitoring instruments for
medical use; diagnostic apparatus and instruments for
medical purposes and use; medical apparatus for renal
monitoring and scanning; medical diagnostic instruments;
medical test kits for diabetes monitoring; medical test kits
for diabetes monitoring for home use.
An apparatus for removing contaminants from a slide comprises a manifold including at least one input port and at least one output port in fluid communication with the at least one input port, the at least one output port being adapted to direct a flow of gas onto a surface of the slide such that the flow of gas removes contaminants from the slide; an aperture for receiving the slide; and an enclosure adapted to capture the contaminants removed from the slide.
B08B 5/02 - Cleaning by the force of jets, e.g. blowing-out cavities
B01D 46/10 - Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
B08B 11/02 - Devices for holding articles during cleaning
B08B 15/04 - Preventing escape of dirt or fumes from the area where they are producedCollecting or removing dirt or fumes from that area from a small area, e.g. a tool
B25J 11/00 - Manipulators not otherwise provided for
82.
COMPUTER-BASED METHODS FOR ANALYZING A PLURALITY OF IMAGES, DIAGNOSTIC AND MEDICAL DEVICES, AND GUI
A first aspect of this disclosure is related to a method for analyzing images, comprising the steps determining a first set of requirements, obtaining a plurality of images of a specimen from an imaging device, in particular in a microscope, based on the first set of requirements, obtaining a second set of requirements, analyzing the specimen from the plurality of images based on the second set of requirements.
Systems and methods of defining a trimline in relation to modeled teeth including a three-dimensional model of one or more intraoral surfaces of the patient. The trimline is for use to manufacture an aligner. For one or more pairs of adjacent teeth, a scallop plane is defined based on a scallop factor. The scallop plane is used to determine the position of scallop points on a line around each tooth adjacent to an interproximal region of the pair of teeth. Transition points are then defined on the line around each tooth apically of the scallop points, and the points connected to form an initial connector curve. The initial connector curve is projected on to a mesh of the three-dimensional model, and smoothing applied to the resulting segmented connector curve. The smoothed connector curves are then joined by teeth curves to form the trimline.
A test and measurement instrument includes an antenna to receive signals containing symbols from a system under test (SUT), one or more analog-to-digital converters (ADC) to sample the signals received from the SUT, a memory to selectively store samples from the ADC, and one or more processors configured to execute code that causes the one or more processors to: receive samples from the ADC, analyze the samples from the ADC to determine whether one or more of the symbols received from the SUT has exceeded an expected modulation boundary for the one or more symbols; identifying a time at which the one or more symbols exceeded the expected modulation boundary as a trigger time; and store samples from a predetermined window of time surrounding the trigger time in the memory.
Methods and systems for operating an OPI of a sample analysis system, the OPI having a transport liquid conduit and a sample removal conduit and being configured to flow a transport liquid therethrough to a capture region, the method including introducing the OPI at a liquid sample in a sample reservoir while supplying the transport liquid at a first flow rate to the capture region, aspirating a first amount of the liquid sample through the removal conduit via the transport liquid flowing at the first flow rate, switching a flow rate of the transport liquid flowing through the OPI to a second flow rate when a first condition is met, the second flow rate being different from the first flow rate, and aspirating a second amount of the liquid sample through the removal conduit via the transport liquid flowing at the second flow rate. Fast flow rate switching is enabled by a transport liquid flow control apparatus comprising a selectable valve having a pair of valve outlets coupled to different flow paths having different flow resistances.
H01J 49/00 - Particle spectrometers or separator tubes
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
86.
REDUCTION OF UNUSED PRECURSORS IN ELECTRON ACTIVATED DISSOCIATION (EAD)
In one aspect, a method of performing mass spectrometry is disclosed, which comprises introducing a plurality of precursor ions into an ion dissociation device, dissociating at least a portion of the precursor ions into a first plurality of product ions having m/z ratios less than an m/z ratio of the precursor ions, discarding at least a portion of any precursor ions remaining subsequent to said dissociation step within said ion dissociation device, and subsequently, allowing at least a portion of said first plurality of product ions to exit from the ion dissociation device through an outlet of the ion dissociation device.
The invention relates to a medical light (100), in particular a dental treatment light for intraoral illumination of a surgical field, the medical light comprising a light source (50), which has at least one LED lamp (52) arranged on a circuit board (51), and a pot-like housing (10), for receiving the light source (50), which forms a light-exit opening (18) provided for light output. The housing comprises a bottom region (11), for planar placement of the circuit board (41), and a wall region (13), which extends peripherally from the bottom region (11) to the light-exit opening, the housing (10) being formed by an outer shell (20) that consists of plastic and an inner shell (30) that consists of metal and abuts the inner face of the outer shell (20), and the circuit board (51) being in planar thermal contact with the inner shell (30) which extends across the bottom region (11) into the wall region (13).
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
88.
DATA PROCESSING DEVICE AND COMPUTER-IMPLEMENTED METHOD FOR COMBINING A FLUORESCENCE EMISSION SIGNAL WITH A SPECULAR REFLECTION SIGNAL IN A MEDICAL OBSERVATION DEVICE
The invention relates to a data processing device (170) and a computer-implemented method for a medical observation device (100), such as a microscope or an endoscope, for observing an object (106) which contains at least one fluorophore (116, 118), wherein the data processing device (170) is configured: to access input image data (120) representative of an image of the object (106), the input image data containing: a reflectance signal (202), the reflectance signal being representative of light (198) reflected off the object and containing a specular reflection signal (206), the specular reflection signal being representative of specular reflection (208) off the object, and a fluorescence emission signal (204), the fluorescence emission signal being representative of fluorescence emitted by the at least one fluorophore; to extract the specular reflection signal; and to generate a digital output image (106) from a combination of the extracted specular reflection signal and the fluorescence emission signal.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
89.
GAS FILTER ELEMENT, FILTER DEVICE AND METHOD OF USE
B01D 46/12 - Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces in multiple arrangements
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
B01D 46/58 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in parallel
B01D 46/10 - Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
A gas filter element comprising: a first end and a second end, having a plurality of inlet channels and a plurality of outlet channels between the first end and the second end, wherein, in an alternating pattern, the plurality of inlet channels each have an inlet channel opening at the first end, and are closed at the second end, and the plurality of outlet channels each have an outlet channel closed at the first end, and an opening at the second end; each of the plurality of inlet channels being surrounded by outlet channels, each inlet channel surrounded by outlet channels forming an individual channel unit; the plurality of inlet channels and the plurality of outlet channels in each individual channel unit having common porous walls.
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
B01D 29/52 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in parallel connection
09 - Scientific and electric apparatus and instruments
Goods & Services
Microscopes; cmos cameras; microscopic software; software,
for use in relation to the following goods: cmos cameras;
parts and accessories, for use in relation to the following
goods: microscopes and cmos cameras.
A sample analysis system analyzes a sample. A panel design generates a sample preparation specification. A preparation instrument prepares a sample using the sample preparation specification to generate a prepared sample. A sample analyzer analyzes the prepared sample. A validator validates an operation of the sample analysis system. A sample analysis system has a transfer station that controls the movement of a probe with respect to a reaction plate. A probe wash module is also disclosed.
A system for acquiring the image data of refrigerated materials is disclosed. The system includes a material management unit with an imaging system. The material management unit further includes a refrigerated chamber in which material vials are stored. The imaging system includes a window positioned on the side of the material management unit that separates an interior space of the refrigerated chamber from an exterior space of the material management unit. The imaging system further includes a camera positioned in the exterior space that captures image data through the window. The window is heated along its sides by a heating element, which functions to prevent condensation from forming on the surface of the window.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
96.
MICROSCOPE CONTROL ARRANGEMENT, MICROSCOPE SYSTEM, METHOD OF CONTROLLING A MICROSCOPE AND COMPUTER PROGRAM
A microscope control arrangement includes one or more processors, one or more storage devices, and a display device. The one or more processors are configured to render a graphical user interface on the display device. The graphical user interface includes control widgets configured to receive user inputs. The one or more processors are further configured to translate the user inputs to the control widgets into at least one of an illumination setting or a detection setting in dependence of a microscopy operation mode selected from of a plurality of microscopy operation modes.
A first aspect of this disclosure relates to a computer-based method of setting an optical focus, comprising the steps of: obtaining a first threshold value for a drift of an optical focus, obtaining a first drift value, wherein it is based on measurements of at least one parameter regarding the focus at different points in time, comparing the first drift value with the first threshold value, outputting the first drift value if it exceeds the first threshold value inadmissibly.
An image processing system is configured to receive at least one reference image, wherein each reference image is a microscopy image capturing cells of a biological sample, wherein the at least one reference image includes at least one reference labeling directed to a reference cellular compartment of the captured cells. The image processing system is configured to employ a trained deep neural network for processing the at least one reference image to generate a target image, wherein the target image includes a target labeling directed to a target cellular compartment of the captured cells, wherein the at least one reference labeling comprises a fluorescence labeling, wherein the reference cellular compartment is a distributed structure within cells, and wherein the target cellular compartment is the cell nucleus.
A system for measuring a concentration of an antibody in a sample includes a polarizer holder retaining first and second detection polarizers. The first detection polarizer restricting passage of light fluoresced from within a container to a first direction. The second detection polarizer restricting passage of light fluoresced from within the container to a second direction. The second direction is perpendicular to the first direction. The system includes a detector for measuring the light fluoresced in the first direction and the light fluoresced in the second direction. The system rotates the polarizer holder about an axis of rotation in alternating directions causing alternate placement of the first and second detection polarizers in an optical path of the light fluoresced from within the container.
The present disclosure provides systems, methods, and kits to directly calibrate fluorescence sensitivity in a flow cytometer using lipid enveloped droplets comprising first, second, and third known concentrations of analytes encapsulated in lipid enveloped droplets, and wherein the analytes have a fluorescent dye. In embodiments, the analytes encapsulated in lipid enveloped droplets comprise a fluorescent dye, a fluorescent dye conjugated to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), a hydrophilic partner that can prevent the analyte from crossing the lipid envelop of the droplet, protein, antibody, antibody fragment, nanobody, or a combination thereof.
