INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITÉ PARIS-SACLAY (France)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) (France)
HOPITAL MARIE LANNELONGUE (France)
Inventor
Cohen-Kaminsky, Sylvia
Humbert, Marc
Dumas, Sebastien
Bru-Mercier, Gilles
Messaoudi, Samir
Brion, Jean-Daniel
Alami, Mouad
Galvani, Gilles
Abstract
The present invention relates to compounds of formula (I);
The present invention relates to compounds of formula (I);
The present invention relates to compounds of formula (I);
for use as peripheral NMDA receptor antagonists.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 451/00 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
2.
Dizocilpine derivatives as peripheral NMDA receptor antagonists
A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 31/46 - 8-Azabicyclo [3.2.1] octaneDerivatives thereof, e.g. atropine, cocaine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 451/00 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
3.
Dizocilpine derivatives as peripheral NMDA receptor antagonists
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
A61K 31/46 - 8-Azabicyclo [3.2.1] octaneDerivatives thereof, e.g. atropine, cocaine
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
A61P 11/00 - Drugs for disorders of the respiratory system
5.
NOVEL DIZOCILPINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE PARIS SUD (France)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) (France)
HOPITAL MARIE LANNELONGUE (France)
Inventor
Cohen-Kaminsky, Sylvia
Humbert, Marc
Dumas, Sebastien
Bru-Mercier, Gilles
Messaoudi, Samir
Brion, Jean-Daniel
Alami, Mouad
Galvani, Gilles
Abstract
Abstract Compounds of formula (I): (CH2), - R3 R2 Rio 9 4 CH3 R, R, for use as peripheral NMDA receptor antagonists. Ri is H, halogen, -OH, -CN, (Ci-C6)alkyl, (C2-C6)alkenyl, (Ci-C4)alkoxy, -C(=NH)(-0H), (Ci-C4)alkyl-C(=NH)(-0H), -NH-00- (Ci- C4)alkyl, -NRiiR12, -N+Ri3Ri4Ri5, (C3-C7)cycloalkyl optionally substituted, 5- or 6-membered aryl or a 5- to 12-membered heteroaryl; said aryl or heteroaryl being optionally substituted. R2 represents (Ci-Cio)alkyl, (Ci-C6)alkyl-OH, (C2-C6)alkenyl or (C2-C6)alkynyl group, n is 1, 2, 3, 4 or 5. R3, R4, R5, R6, R7, R8, R9 and Rio represent, independently of each other, H, halogen, -OH, -N3, -SCF3, a trifluoromethyl, (Ci-C6)alkyl, (Ci-C6)alkoxy, (Ci- C6)alkyl-OH, - NR11R12, -N+R13R14R16, a 5- or 6-membered aryl or a 5- to 12-membered heteroaryl. R11, Ri4, and Ri5 represent, independently of each other, H or a (Ci-C6)alkyl. X- is an anionic counterion. When R2 is a methyl group, R3, R4, R5, R6, R7, R8, R9 and Rio are H, n is 1 and Ri is not H. Date Recue/Date Received 2020-08-12
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
A61P 11/00 - Drugs for disorders of the respiratory system
patents
