The present invention provides a method of identifying and mitigating a risk of deathloss of an animal, comprising receiving, at a processor from a hematology analyzer, information obtained from a sample from said animal, wherein said information comprises a leukocyte absolute count and a leukocyte differential from said sample, said sample comprising leukocytes, analyzing, by said processor, said leukocyte absolute count and said leukocyte differential to determine a survivability index for said animal, and managing the animal based on the survivability index.
A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and/or identifying an amount of red blood cells and/or hematocrit, and/or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.
A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and/or identifying an amount of red blood cells and/or hematocrit, and/or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.
The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with an index of infection; and d) initiating antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy of said animal on the basis of said comparing step.
The present invention provides a method of identifying and mitigating a risk of deathloss of an animal, comprising receiving, at a processor from a hematology analyzer, information obtained from a sample from said animal, wherein said information comprises a leukocyte absolute count and a leukocyte differential from said sample, said sample comprising leukocytes, analyzing, by said processor, said leukocyte absolute count and said leukocyte differential to determine a survivability index for said animal, and managing the animal based on the survivability index.
An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle. The needle is optionally removed and blood dispensed from the body into a test or collection device by actuating the ejector.
An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary use of a non-downloadable web application for viewing, benchmarking, and tracking a dairy cow herd's udder health and milk quality data
9.
METHODS AND COMPOSITIONS FOR REDUCING ANTIBIOTIC ADMINISTRATION TO FARM ANIMALS
The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with an index of infection; and d) initiating antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy of said animal on the basis of said comparing step.
A23K 50/00 - Feeding-stuffs specially adapted for particular animals
A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
10.
METHODS AND COMPOSITIONS FOR REDUCING ANTIBIOTIC ADMINISTRATION TO FARM ANIMALS
The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with an index of infection; and d) initiating antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy of said animal on the basis of said comparing step.
A23K 50/00 - Feeding-stuffs specially adapted for particular animals
A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
11.
METHODS AND COMPOSITIONS FOR DETECTING MYCOPLASMA EXPOSURE
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C07K 14/30 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Mycoplasmatales, e.g. Pleuropneumonia-like organisms [PPLO]
G01N 33/487 - Physical analysis of biological material of liquid biological material
An apparatus useful for the rapid collection of blood from a subject (e.g., the vein of a bovine subject) and dispensing the blood therefrom into a collection device includes: (a) a capillary body having a capillary chamber formed therein, with the chamber having an inlet and outlet, and with said chamber configured to draw blood therein through the inlet by capillary action; (b) a hollow barrel connected to the chamber outlet; (c) a plunger positioned in the barrel; and (d) a hollow needle connected to the capillary body, with the hollow needle in fluid communication with the capillary chamber through the capillary inlet, so that blood can be rapidly drawn into the capillary chamber through the needle by the combined action of vein pressure (or other pressure, if present, such as arterial pressure) and capillary action.
A microscope assembly for use in an automated microscope apparatus has a support frame; a cartridge magazine actuator assembly connected to the support frame; a subframe; a plurality of vibration isolators connecting the support frame to the subframe; an XYZ drive connected to the subframe; and an optical stage connected to the subframe. In some embodiments the assembly further includes a cartridge gripper connected to said XYZ drive. In some embodiments, the cartridge magazine actuator assembly includes an input element, an output element, and a transfer assembly interconnecting the input element and the output element, with the transfer assembly configured to linearly advance the output element upon linear depression of the input element.
An apparatus (or "container fixture") useful in preparing a liquid sample such as a biological fluid for further analysis, the liquid sample contained in a sample container, is described. The apparatus has: (a) a body having a top portion and a front side wall portion, (b) at least one receptacle formed in the body and extending downward from the body top portion, the receptacle configured to receive the sample container, and with the receptacle having a back side wall portion; (c) at least one magnet connected to the receptacle back side wall portion; and (d) optionally, a retention member connected to the body and configured to force the container against the at least one magnet when the container is positioned in the receptacle.
The present invention relates to an leucocyte antigen mediated microfluidic assay and a microfluidic device for analyzing a subjects' body fluids containing leucocytes to determine if the subject has been previously exposed to a predetermined antigen.
A device for detecting at least one analyte (and in some embodiments two, three, or four or more different analytes) in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid therein, wherein said chamber is an elongate chamber having a length axis; (ii) a carrier or agitator in said elongate chamber, said carrier or agitator having opposite end portions and a side portion, the carrier or agitator dimensioned to travel in said chamber along said length axis and/or permit said liquid sample to flow in the chamber therearound, either (or both) thereby agitating the liquid sample; and (iii) at least one anti-analyte antibody coupled to either the carrier and/or the chamber side wall.
A collection device includes a base housing member having at least one chamber. A cover housing member has at least one aperture therein, and the cover housing member is configured to cover the base housing member such that the at least one aperture is positioned in fluid communication with the at least one chamber. The cover housing member includes a cartridge holding interface configured to releasably engage with a cartridge that is configured to cover and receive a fluid from the at least one chamber via the at least one aperture.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A01J 5/04 - Milking machines or devices with pneumatic manipulation of teats
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
A61B 90/96 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes
A61B 90/90 - Identification means for patients or instruments, e.g. tags
A61B 90/94 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text
A61B 90/98 - Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
A microscope assembly for use in an automated microscope apparatus has a support frame; a cartridge magazine actuator assembly connected to the support frame; a subframe; a plurality of vibration isolators connecting the support frame to the subframe; an XYZ drive connected to the subframe; and an optical stage connected to the subframe. In some embodiments the assembly further includes a cartridge gripper connected to said XYZ drive. In some embodiments, the cartridge magazine actuator assembly includes an input element, an output element, and a transfer assembly interconnecting the input element and the output element, with the transfer assembly configured to linearly advance the output element upon linear depression of the input element.
A device for detecting at least one analyte in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid (e.g., milk) therein, wherein said chamber is an elongate chamber having a length axis; (ii) a (stationary or movable) carrier (in some embodiments in the form of an end cap, or connected to an end cap; in other embodiments in the form of an agitator in said elongate chamber).
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like.
An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.
An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.
An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.
An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.
A collection device includes a base housing member having at least one chamber. A cover housing member has at least one aperture therein, and the cover housing member is configured to cover the base housing member such that the at least one aperture is positioned in fluid communication with the at least one chamber. The cover housing member includes a cartridge holding interface configured to releasably engage with a cartridge that is configured to cover and receive a fluid from the at least one chamber via the at least one aperture.
A device for detecting at least one analyte (and in some embodiments two, three, or four or more different analytes) in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid therein, wherein said chamber is an elongate chamber having a length axis; (ii) a carrier or agitator in said elongate chamber, said carrier or agitator having opposite end portions and a side portion, the carrier or agitator dimensioned to travel in said chamber along said length axis and/or permit said liquid sample to flow in the chamber therearound, either (or both) thereby agitating the liquid sample; and (iii) at least one anti-analyte antibody coupled to either the carrier and/or the chamber side wall.
A device for detecting at least one analyte generally comprises (i) a support having a chamber for receiving a biological fluid therein, wherein said chamber is an elongate chamber having a length axis; (ii) a carrier or agitator in said elongate chamber, said carrier or agitator having opposite end portions and a side portion, the carrier or agitator dimensioned to travel in said chamber along said length axis and/or permit said liquid sample to flow in the chamber therearound, either (or both) thereby agitating the liquid sample; and (iii) at least one anti-analyte antibody coupled to either the carrier and/or the chamber side wall. Methods of using the device are also described.
A sample cartridge (40) for microscopic imaging of a biological sample comprises a body having an end portion (43) and a pair of generally parallel opposing side edge portions (44), a locking edge portion (45) formed on the body; a carrier removably connected to or permanently connected to the body; and at least one anti-analyte antibody coupled to either the carrier or to the chamber (41) side wall portion (e.g., at the surface to be imaged, or supporting the sample to be imaged). An XYZ stage (101) for receiving such a cartridge (40) is also described.
A method of automatically focusing a microscope on a specimen is carried out by capturing an image from each of a plurality of focal planes in or on said specimen, calculating a focus score for each of said images, selecting the focal plane corresponding to the image having the best focus score, and then repositioning said specimen relative to said microscope so that said microscope is focused on said selected focal plane, the method includes a plurality of exogenous targets in or on said specimen, which aids in focusing in the event particular objects of interest, such as cells/pathogens that may or may not be in the sample, are not present, or are present in low numbers. Automated microscopes and microscope cartridges useful in such methods are also described, along with methods of detecting pathogens in biological samples.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Non-medical research laboratory analysis kits sold as a unit and containing electronic analyzers for measuring, testing and analyzing milk and other bodily fluids of animals and disposable slides used for the detection of the immune status of, and the determination of the metabolic status of animals. Veterinary medical apparatus consisting of an electronic reading device and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals for medical treatment of animals. Medical information services, namely, analysis and reporting of statistics regarding the exposure to pathogens by or in, the immune status of, and the metabolic status of animals.
34.
AAD ADVANCED ANIMAL DIAGNOSTICS INFORMATION THAT COUNTS
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Non-medical research laboratory analysis kits sold as a unit and containing electronic analyzers for measuring, testing and analyzing milk and other bodily fluids of animals and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals. Veterinary medical apparatus consisting of an electronic reading device and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals for medical treatment of animals. Medical information services, namely, analysis and reporting of statistics regarding the exposure to pathogens by or in, the immune status of, and the metabolic status of animals.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Non-medical research laboratory analysis kits sold as a unit and containing electronic analyzers for measuring, testing and analyzing milk and other bodily fluids of animals and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals Veterinary medical apparatus consisting of an electronic reading device and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals for medical treatment of animals Veterinary research information services, namely, providing statistical analysis and information regarding the exposure to pathogens by or in, the immune status of, and the metabolic status of animals
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Non-medical research laboratory analysis kits sold as a unit and containing electronic analyzers for measuring, testing and analyzing milk and other bodily fluids of animals and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals Veterinary medical apparatus consisting of an electronic reading device and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals for medical treatment of animals
Veterinary medical apparatus consisting of an electronic reading device and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals for medical treatment of animals
09 - Scientific and electric apparatus and instruments
Goods & Services
Non-medical research laboratory analysis kits sold as a unit and containing electronic analyzers for measuring, testing and analyzing milk and other bodily fluids of animals and disposable slides used for the detection of pathogens in, the detection of exposure to pathogens by or in, the determination of the immune status of, and the determination of the metabolic status of animals
