Abstract

As terminal alkenes, so-called alpha-olefines, are easily available and relatively cheap starting materials, their selective transformations are one of the fundamental reactions in organic chemistry which are used in many large-scale chemical processes and academic laboratories. Markovnikov-type alkene reactivity encompasses a significant portion of chemical reaction space for unsaturated hydrocarbons and offers a direct method for synthesizing fundamental commodities and fine chemicals. Equally important is the availability of complementary anti-Markovnikov type addition products. However, this objective has proven to be a challenging task for organic chemists. The recently discovered chemistry of alkenyl-sulphonium salts creates a new opportunity in forming anti- Markovnikov type addition products.

IPC Classes  ?

• C07C 67/00 - Preparation of carboxylic acid esters
• C07C 67/30 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
• C07C 67/31 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
• C07C 247/12 - Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
• C07C 253/00 - Preparation of carboxylic acid nitriles
• C07C 313/04 - Sulfinic acidsEsters thereof
• C07C 315/00 - Preparation of sulfonesPreparation of sulfoxides
• C07C 319/14 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
• C07D 487/04 - Ortho-condensed systems
• C07C 331/14 - Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• C07C 381/12 - Sulfonium compounds
• C07B 37/04 - Substitution
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07D 213/64 - One oxygen atom attached in position 2 or 6
• C07D 213/70 - Sulfur atoms
• C07D 295/26 - Sulfur atoms
• C07D 313/00 - Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
• C07D 339/08 - Six-membered rings
• C07F 9/54 - Quaternary phosphonium compounds
• C07C 229/14 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
• C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
• C07C 255/19 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
• C07C 317/14 - SulfonesSulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
• C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
• C07C 67/313 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups

Abstract

Compounds for use against a viral infection The invention relates to hexahydronaphthalen-2-one derivatives, such as petasol, petasin and isopetasol, for use in the prevention or the treatment of viral infections. In particular compounds extracted from Darksidea spp. are provided for use in the treatment of SARS-CoV-2 infection.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates to the field of cancer therapy. In particular, a highly effective chemotherapy is provided in the form of liposome-encapsulated 2-deamino-2-pyrrolino-daunorubicin, which has been found to eliminate cancer cells and to support overall survival without causing severe undesired effects in mouse models of different types of cancer.

IPC Classes  ?

• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to compounds for use in the prevention or the treatment of infections caused by a coronavirus. In particular compounds extracted from Darksidea spp. are provided for use in the tre- atment of a coronavirus infection, in particular an infection by feline coronavirus or porcine coronavirus.

IPC Classes  ?

• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to compounds of formula (I) or (II) pharmaceutically acceptable salts, solvates, tautomers, stereoisomers thereof, including enantiomers, diastereomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, and pharmaceutical uses of the compounds.

IPC Classes  ?

• C07D 487/14 - Ortho-condensed systems

Abstract

Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the brain impairs mitochondrial functions that could trigger further damaging cellular processes. Altered levels of protein biomarkers are discloses to be useful in the diagnosis of vascular dementia.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

α,β-Unsaturated aldehydes are useful products as such in agrochemistry, but also potential intermediates for the preparation of important insect pheromones and kairomones. Until now, primarily the thermodynamically more stable (E)-α,β-unsaturated aldehydes have been identified as useful intermediates in the production of conjugated diene pheromone compounds, however, their practical and cost-effective synthesis on an industrial scale remains challenging. The problem to be solved by the present invention is to provide a method for selective oxidation of alkenes to α,β-unsaturated carbonyls which can be further transformed into pheromones and kairomones preferably without isolation and significant loss of the existing stereochemical purity.

IPC Classes  ?

• C07C 45/56 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds from heterocyclic compounds
• C07C 51/373 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
• C07C 67/29 - Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
• C07C 67/313 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• C07C 309/73 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07D 309/06 - Radicals substituted by oxygen atoms
• C07C 47/21 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
• C07C 47/228 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
• C07C 47/225 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
• C07C 47/277 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• C07C 47/26 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
• C07C 47/24 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
• C07C 49/597 - Unsaturated compounds containing a keto group being part of a ring of a five-membered ring
• C07C 49/603 - Unsaturated compounds containing a keto group being part of a ring of a six-membered ring, e.g. quinone methides
• C07C 49/607 - Unsaturated compounds containing a keto group being part of a ring of a seven- to twelve-membered ring
• C07C 59/74 - Unsaturated compounds containing —CHO groups
• C07C 69/78 - Benzoic acid esters
• C07C 69/73 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
• C07C 255/17 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and doubly-bound oxygen atoms bound to the same acyclic carbon skeleton
• C07D 339/08 - Six-membered rings

Abstract

The primary subject of the invention is an iron oxide/hydroxide-containing conducting polymer composite, which comprises a) a conducting polymer, and b) an iron oxide/hydroxide compound incorporated in the conducting polymer wherein the composite contains iron oxide/hydroxide compound other than magnetite, and the conducting polymer is different from polyaniline (PANI). The further subject of the invention is the process for the electrochemical production of the above-mentioned conducting polymer composite by one of the following processes: Process I, which comprises the following steps: a) providing a conducting polymer layer; b) electrochemical reduction of the conducting polymer layer; c) contacting the reduced conducting polymer layer with an aqueous solution of ferrate ions; d) optionally repeating steps b) and c); e) optionally separating and drying the obtained composite; or Process II, which comprises the following steps: a) providing a conducting polymer layer; b) contacting the conducting polymer layer with an aqueous solution of ferrate ions; c) electrochemical oxidation of the conducting polymer layer in an aqueous solution of ferrate ions; d) electrochemical reduction of the oxidized conducting polymer layer in an aqueous solution of ferrate ions; e) optionally repeating steps c) and d); e) optionally separating and drying the obtained composite.

IPC Classes  ?

• C08K 3/22 - OxidesHydroxides of metals
• C08J 7/12 - Chemical modification
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances

Goods & Services

Commercial intermediation, Marketing services, in relation to the following services: research and information services; Commercial intermediation, Marketing services, in relation to the following goods: Training courses; Business project management; Organising business activities related to consortium members; Marketing services, in relation to the following goods: Analysis, questionnaires, Data bases. Financing of research and development; Financial support for social innovation activities; Professional networking, financing of community development, intermediary financing. Mining extraction, Oil and gas drilling, Reclamation of mine water. Water treating, Water purification, Soil or water treatment services [environmental remediation services]. Tuition; Providing of training; Management of education services; Transfer of business knowledge and know-how [training]; Publishing documents on training, science, social issues; Publication and dissemination of social innovation results; Organisation of professional conferences, Arranging professional workshop, organization of training courses, organisation of professional events; Design of publications. Scientific services; Research services; Research and development of new products for others; Social innovation services; Professional support, evaluation and testing of social innovation activities; Scientific and research project management services, Engineering project management services; technical planning and technical project management; Database design, Administration of databases, Development of databases, Publication of databases; Compilation, Operation, Development, in relation to the following goods: Questionnaires for the evaluation of research and development work. Agriculture services, Agricultural advice on water management. Intellectual property services; Registration of intellectual property, Management of intellectual property; Licensing of intellectual property, Exploitation of intellectual property; Intellectual property consultancy.

Abstract

The invention relates to cancer biology, more specifically to the treatment of KRAS mutant cancers. A potent cancer therapy is provided by the combination of a farnesyl transferase inhibitor compound and a KRAS inhibitor compound.

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to compounds of formula (I) or (II) pharmaceutically acceptable salts, solvates, tautomers, stereoisomers thereof, including enantiomers, diastereomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, and pharmaceutical uses of the compounds.

IPC Classes  ?

• C07D 487/14 - Ortho-condensed systems

Abstract

The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds. The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds.

IPC Classes  ?

• C07D 471/14 - Ortho-condensed systems
• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to cancer biology, more specifically to the treatment of KRAS mutant cancers. A potent cancer therapy is provided by the combination of a farnesyl transferase inhibitor compound and a KRAS inhibitor compound.

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

Compounds for use against a viral infection The invention relates to hexahydronaphthalen-2-one derivatives, such as petasol, petasin and isopetasol, for use in the prevention or the treatment of viral infections. In particular compounds extracted from Darksidea spp. are provided for use in the treatment of SARS-CoV-2 infection.

IPC Classes  ?

• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates to the field of cancer therapy. In particular, a highly effective chemotherapy is provided in the form of liposome-encapsulated 2-deamino-2-pyrrolino-daunorubicin, which has been found to eliminate cancer cells and to support overall survival without causing severe undesired effects in mouse models of different types of cancer.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61P 35/00 - Antineoplastic agents

Abstract

The primary subject of the invention is a separator for separating the anode and cathode compartments in electrochemical cells, comprising (a) a support made of polyethylene and/or polypropylene fibres, and b) a Fe(III)-containing precipitate deposited on the support according to point a). In the separator, the support may be a woven or non-woven support, preferably a non-woven textile having a surface density of approx. 5-100 g/m2, preferably approx. 15-70 g/m2, more preferably approx. 25-40 g/m2.

IPC Classes  ?

• C25B 13/02 - DiaphragmsSpacing elements characterised by shape or form
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 13/07 - DiaphragmsSpacing elements characterised by the material based on inorganic materials based on ceramics
• C25B 1/14 - Alkali metal compounds
• C01G 49/00 - Compounds of iron

Abstract

The primary subject of the invention is an iron oxide/hydroxide -containing conducting polymer composite, which comprises a) a conducting polymer, and b) an iron oxide/hydroxide compound incorporated in the conducting polymer wherein the composite contains iron oxide/hydroxide compound other than magnetite, and the conducting polymer is different from polyaniline (PANI). The further subject of the invention is the process for the electrochemical production of the above-mentioned conducting polymer composite by one of the following processes: Process I, which comprises the following steps: a) providing a conducting polymer layer; b) electrochemical reduction of the conducting polymer layer; c) contacting the reduced conducting polymer layer with an aqueous solution of ferrate ions; d) optionally repeating steps b) and c); e) optionally separating and drying the obtained composite; or Process II, which comprises the following steps: a) providing a conducting polymer layer; b) contacting the conducting polymer layer with an aqueous solution of ferrate ions; c) electrochemical oxidation of the conducting polymer layer in an aqueous solution of ferrate ions; d) electrochemical reduction of the oxidized conducting polymer layer in an aqueous solution of ferrate ions; e) optionally repeating steps c) and d); e) optionally separating and drying the obtained composite.

IPC Classes  ?

• C09D 5/24 - Electrically-conducting paints
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

The invention relates to a mutated recombinant fusion protein comprising a human ACE2 domain and a human IgG-Fc domain, wherein in comparison to the ACE2 domain of SEQ ID NO: 1, the ACE2 domain of the mutated recombinant fusion protein comprises mutation (i) at positions R275, T373, H507; or (ii) at positions R275, H347, T373, H507, I515; or (iii) at positions R275, H347, H507, I515; or (iv) at position I515; or (v) at positions T373, I515; or (vi) at position H507; or (vii) at positions H507, I515; or (viii) at position T373. The invention also relates to said mutated recombinant fusion protein, further comprising a signal peptide. The invention further relates to said mutated recombinant fusion protein for use in a method of treating an infection disease caused by a coronavirus capable of binding ACE2. The invention also relates to a polynucleotide encoding said mutated recombinant fusion protein, and to a vector comprising said polynucleotide, as well as to a host cell comprising said vector.

IPC Classes  ?

• C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)

Abstract

The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61P 35/00 - Antineoplastic agents
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
• C07D 471/14 - Ortho-condensed systems

Abstract

An assembly for switching optical paths, which assembly includes multiple optical channels for guiding an illuminating light to a specimen and for guiding the light coming from the specimen to an image recording unit. The assembly also includes a plurality of light guiding mirrors and at least one light modifying element in each optical channel for directing the illuminating light and the light coming from the specimen. In each of the multiple optical channels the at least one light modifying element includes a stationary dichroic mirror. Further details regarding the arrangement and rotation of the mirrors, and how the mirrors direct the illuminating light and light coming from the specimen, are defined herein.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The present invention relates to compounds of formula (I) or (II) pharmaceutically acceptable salts, solvates, tautomers, stereoisomers thereof, including enantiomers, diastereomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, and pharmaceutical uses of the compounds.

IPC Classes  ?

• C07D 487/14 - Ortho-condensed systems

Abstract

The primary subject of the invention is a separator for separating the anode and cathode compartments in electrochemical cells, comprising (a) a support made of polyethylene and/or polypropylene fibres, and b) a Fe(III)-containing precipitate deposited on the support according to point a). In the separator, the support may be a woven or non-woven support, preferably a non- woven textile having a surface density of approx. 5-100 g/m2, preferably approx. 15-70 g/m2, more preferably approx. 25-40 g/m2.

IPC Classes  ?

• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 13/02 - DiaphragmsSpacing elements characterised by shape or form
• C25B 1/14 - Alkali metal compounds

Goods & Services

downloadable application software; downloadable game software; downloadable and recorded software products; downloadable computer games; video games recorded on data carriers; downloadable video game software. Paper, cardboard; Books; Copybooks; Syllabi; Paper for handwriting; Paper creasers [office requisites]; Date indicators; Writing or drawing books; Note pads; Greeting cards; Printed promotional material; Paper for packaging.; stationery. games; toys; hand-held electronic video games; parlour games. Providing online game software; Providing online educational software; providing online use of game software. Providing non-downloadable software; providing temporary use of non-downloadable software; providing software applications.

Abstract

The assembly (10) for switching optical paths comprises multiple optical channels for guiding an illuminating light to a specimen and for guiding the light coming from the specimen to an image recording unit, the assembly further comprising a plurality of light guiding mirrors and at least one light modifying element in each optical channel for directing the illuminating light and the light coming from the specimen. In each of the multiple optical channels the at least one light modifying element comprises a stationary dichroic mirror (14a-i). The light guiding mirrors include the following mirrors: a first rotatable light guiding mirror (32) for directing the illuminating light ray (12a) to a selected dichroic mirror (14a-i); a second rotatable light guiding mirror (22) for guiding a light ray (12b) reflected by the dichroic mirror (14a-i) to the specimen and for directing a light ray (12c) coming from the specimen to the dichroic mirror (14a-i); a third stationary light guiding mirror (18-i) and a fourth rotatable light guiding mirror (42), wherein the third light guiding mirror (18-i) directs a light ray (12d) passed by the dichroic mirror (14a-i) to the fourth light guiding mirror (42), wherein a rotating unit is coupled to the first, second and fourth light guiding mirrors (32, 22, 42), and the rotational axis of said light guiding mirrors (32, 22, 42) align with a common geometric axis (S). The dichroic mirrors (14a-i) associated with the respective optical channels and the third light guiding mirror (18-i) are arranged at a predefined angular distance (γ) from each other around said geometric axis (S).

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The present invention relates to compounds of formula (I) or (II) pharmaceutically acceptable salts, solvates, tautomers, stereoisomers thereof, including enantiomers, diastereomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, and pharmaceutical uses of the compounds.

IPC Classes  ?

• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• C07D 487/14 - Ortho-condensed systems
• C07D 495/14 - Ortho-condensed systems
• C07D 513/14 - Ortho-condensed systems

Abstract

The invention relates to a capillary channel, which comprises a trap section (1) having a coating, and further comprises a collector section (2) having a volume which is at least as large as that of the trap section (1), and a reader section (3) adjacent to the collector section (2), wherein the reader section (3) optionally comprises one or more physical and/or chemical sensors adapted for measuring a flow rate and/or one or more markings for visual reading of a liquid front position, and wherein the collector section (2) is located in the part between the trap section (1) and the reader section (3) of the capillary channel. The invention also provides a capillary channel system, which comprises at least one measuring channel, which measuring channel is a capillary channel according to the invention, wherein the coating comprises an antigen, and the system comprises at least one negative control channel and optionally at least one positive control channel, and optionally at least one sample distributing part which communicates with the channels. The invention also provides a method for the analysis of immunoreactivity on an antigen array, wherein an antigen array comprising one or more antigens and optionally one or more reference substances is contacted with a sample, and the immune complexes formed by the one or more antigens and one or more components of the sample which may be captured by the antigens are detected by cells, wherein for the cells the sample serves as a source, or the cells are from a source other than the sample. The method is preferably carried out with a device according to the invention. The invention also encompasses kits and uses.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The invention relates to an apparatus for killing insects, especially horseflies, the apparatus comprising a mechanical slapping element (12) and an electric motor rotating the mechanical slapping element (12), characterised by comprising a solar cell (10) providing at least partly the power supply for the electric motor, the solar cell (10) having a horizontally arranged surface (11) reflecting at least a part of incident light in a horizontally polarised form, and the mechanical slapping element (12) is arranged above the surface (11) of the solar cell (10) in a way that it can be rotated in a plane parallel with the surface (11) of the solar cell (10).

IPC Classes  ?

• A01M 1/04 - Stationary means for catching or killing insects with devices attracting the insects using illumination
• A01M 1/22 - Stationary means for catching or killing insects by electric means

Abstract

Disclosed are transgenes and expression vectors for expressing human G-potein coupled receptors in the nematode worm Caenorhabditis elegans. Furthermore methods are also disclosed for preparing a transgenic C.elegans comprising said receptors, as well as methods for testing the effects of compounds on human G-protein coupled receptors.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/12 - Genes encoding animal proteins
• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Abstract

The invention is a method for measuring cloud-base distance comprising the steps of taking linear polarization images of a sky-portion from essentially the same point of view and at essentially the same time by means of at least three linear polarizing filters with different transmission directions, selecting points equivalent to each other on the linear polarization images, determining a degree of linear polarization and a total intensity of an incident light beam arriving on the points equivalent to each other by means of the respective intensities of the points, and determining a relative cloud-base distance for the points equivalent to each other based on the degree of linear polarization and on the total intensity, as well as on a pre-determined degree of linear polarization and on a pre-determined total intensity belonging to a cloudless sky. Further, the invention is an apparatus for measuring polarization, comprising an optical device generating a light beam (34) from a sky-portion, an image recording device (24) capable of receiving the light beam (34) and taking an image thereof, at least three linear polarizing filters (26, 26', 26") with different transmission directions and the polarizing filters (26, 26', 26") are arranged affecting different parts of the light beam (34), which parts of the light beam are projected onto a common image recording device (24).

IPC Classes  ?

• G06T 7/00 - Image analysis
• G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
• G01W 1/02 - Instruments for indicating weather conditions by measuring two or more variables, e.g. humidity, pressure, temperature, cloud cover or wind speed
• G01J 4/04 - Polarimeters using electric detection means

Abstract

The invention relates to peptides with general formula (I), X1CTX2X3X4CX5 (I) where X1 is: M, F, V, A, I, and X2 is: R, K, and X3 is: K, R, L, A and X4 is: L, G, M, A, W, Y, and X5 is: W, Y, L, M, N, E, G; and their pharmaceutically acceptable salts, esters and prodrugs. The invention also relates to pharmaceutical preparations and kits containing them, and to screening and isolation procedures containing them, and to their use in the production of pharmaceutical preparations.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 17/00 - Drugs for dermatological disorders
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 27/06 - Antiglaucoma agents or miotics
• A61P 25/16 - Anti-Parkinson drugs
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

The invention relates to an annealing incubator (10) constructed for the inverted microscopic examination of biological preparations placed in a biological preparation plate (20). The invention is based on that it contains a nest (12) created for the plate, which nest (12) is formed by a base board (14), a cover board (16) and an internal wall (18) laterally surrounding the plate (20), in the lower and upper range of the plate (20) the internal wall (18) fits to the wall of the plate (20) with a clearance, while in the central range of the plate (20) it widens with a gap (22) with respect to the plate (20) allowing gas flow around the plate (20); the base board (14) contains an objective window (24) revealing the part of the plate (20) inside the nest (12) containing the biological preparation, while the cover board (16) contains an illumination window (26) revealing the part of the plate (20) inside the nest (12) containing the biological preparation, and the incubator (10) contains a gas-flow opening (28) for blowing annealing gas into the central wider range of the nest (12). The invention also relates to annealing equipment (50), which contains such an incubator (10), and to a procedure for manufacturing such incubators (10).

IPC Classes  ?

• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides
• G01N 1/44 - Sample treatment involving radiation, e.g. heat
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The invention relates to peptides according to general formula (I) GX1CSX2SX3PPX4CX5PD where X1 is Y, M, W, I, V, A, and X2 is R, K, and X3 is Y, F, I, M, L, E, D, H, and X4 is V, I, H, and X5 is I, V, Y, F, W; and to their pharmaceutically acceptable salts, esters and prodrugs. Furthermore the invention relates to pharmaceutical preparations and kits containing them, and to screening and isolation procedures using them, and to their use in the production of pharmaceutical preparations.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 7/64 - Cyclic peptides containing only normal peptide links

Abstract

The invention is an igniting liquid comprising 50 to 100 % by weight gamma- Valerolactone. The invention is furthermore the use of gamma-Valerolactone for producing an igniting liquid or the use of gamma-Valerolactone as an igniting liquid or igniting liquid additive.

IPC Classes  ?

• C10L 11/04 - Fire-lighters consisting of combustible material
• C10L 9/10 - Treating solid fuels to improve their combustion by using additives