A diagnostic analyzer includes a rotating device, a first optical reader, and a second optical reader. The rotating device includes a first darkened compartment, a second darkened compartment, and an optical path along which the first darkened compartment and the second darkened compartment travel. The first optical reader is operable to read the first darkened compartment and the second optical reader is operable to read the second darkened compartment.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
2.
BACKGROUND INTERFERENCE MITIGATION FOR HIGH SENSITIVITY KETONE SENSING
The present disclosure relates to a method of improving the sensitivity of sensing ketones that includes providing i) a ketone sensing electrode comprising a ketone-responsive enzyme and a redox mediator; and ii) a background sensing electrode comprising a redox mediator and no ketone-responsive enzyme and applying a potential less than +40 mV to provide a steady state. The ketone sensing electrode and background sensing electrode can be simultaneously or sequentially disconnected from the circuit to allow the charge to accumulate for a set period of time. After sufficient charge has been built up, both electrodes can be reconnected to the circuit. The ketone signal can be measured by subtracting a signal obtained from the background sensing electrode from a signal obtained from the ketone sensing electrode. The present disclosure further relates to a ketone sensor comprising a first sensing electrode that senses ketone and a second sensing electrode that senses the background.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
3.
MEDICAL DEVICE INSERTERS AND PROCESSES OF INSERTING AND USING MEDICAL DEVICES
An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.
A system is provided that includes one or more electrodes configured to be implanted proximate to a sensing site, and a memory configured to store first and second sets of filter parameters that define first and second noise stop bands. The system also includes an implantable medical device (IMD) that has inputs configured to receive sensed signals, the sensed signals include frequency components associated with physiology activity and frequency components associated with noise. The IMD also includes a band-stop filter communicating with the sensing channel inputs. When executing program instructions, a processor switches the band-stop filter from the first set of filter parameters to the second set of filter parameters to shift from the first noise stop band to the second noise stop band based on the noise in the environment of the patient.
In some embodiments, a method of delivering a medical device includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon disposed at the distal end of the catheter, and at least one sensor disposed proximal the inflatable balloon, inflating the inflatable balloon in a first stage, measuring a first pressure with the at least one sensor, and calculating a fluid resistance factor during the first stage.
In some examples, a system includes a transparent sheath defining a lumen, a first optical coherence tomography catheter configured for cardiovascular imaging having a first imaging probe comprising a first end, a second end, and a first lens assembly disposed at the second end of the first imaging probe, the first imaging probe being configured to transmit light between the first and second ends thereof, and a prosthetic heart valve disposed about the transparent sheath.
Systems, devices, and methods for sensor wearer identity verification are provided. For example, sensor wearer identity verification can be performed by determining a transmission metric or the number of one or more time-stamped transmissions of data indicative of an analyte level. In addition, sensor wearer identity verification can also be performed by determining the number of one or more time-stamped transmissions of data indicative of an analyte level that are timely adjacent to a user response to a query.
A method of implanting a prosthetic heart valve may include inserting a delivery catheter into a patient's vasculature while the prosthetic heart valve is in a crimped condition on the delivery catheter. The delivery catheter may be advanced through the patient's vasculature until the crimped prosthetic heart valve is positioned within a native valve annulus. While the prosthetic heart valve is within the native valve annulus, a first stage of deployment may be performed in which the balloon is inflated at a first rate of inflation to begin expanding the prosthetic heart valve. After performing the first stage of deployment, a second stage of deployment may be performed in which the balloon is inflated at a second rate of inflation that is greater than the first rate of inflation. After performing the second stage of deployment, the prosthetic heart valve may be anchored within the native valve annulus.
Systems and methods which provide a slip ring anchor configuration in which an anchor body includes inelastic members and a fluted elastomeric casing operable in cooperation to impart a radial compressive force to a corresponding lead body are described. A slip ring anchor body may comprise a plurality of inelastic members alternately disposed in flutes of a fluted elastomeric casing portion of the anchor body. The fluted elastomeric casing may form an anchor lumen through which a lead body may be inserted. Once a slip ring anchor is disposed at a desired position axially along the lead body, manipulation of one or more slip rings may be used to cause a radial compressive force to be imparted upon the lead body. A slip ring actuator tool may be used to manipulate a slip ring between unlocked and locked positions.
In some embodiments, a method includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon, a handle coupled to the catheter, and a memory for storing data disposed within the handle, recording at least one of part-to-part noise factors and process variation factors and storing it in the memory, calculating an adjusted inflation parameter based on the at least one of part-to-part noise factor and process variation factor, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, and inflating the balloon according to the adjusted inflation parameter.
A system includes: a processing circuit including a memory device coupled to a processor, the memory device configured to store instructions thereon that, when executed by the processor, cause the processor to: generate synthetic class data using minority class data to obtain balanced class data including the minority class data corresponding to patients with a health failure, the synthetic class data corresponding to the health failure, and majority class data corresponding to patients without the health failure; automatically reduce, using a machine learning classifier, risk factor variables for the health failure to a reduced set of risk factor variables based on the balanced class data; and execute the machine learning classifier using as input a reduced set of risk factor variable data for a patient corresponding to the reduced set of risk factor variables to generate a probability indicator of the health failure for the patient.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
12.
METHODS, SYSTEMS, COMPOUNDS, AND KITS FOR DETERMINING AN ANALYTE OF INTEREST IN A TEST SAMPLE
Provided herein are methods, systems, and kits for determining the concentration or level of an analyte of interest using a competitive and sandwich immunoassay. Also provided herein are acridinium-containing and acridone-containing compounds for use in assays to detect the presence of or determine the concentration or level an analyte of interest in a sample, e.g., a biological sample.
Bodily fluid sampling devices are disclosed herein. An example apparatus is rotatable between a first position and a second position, and includes a wall including a top surface and a slot, a spring, and a carrier coupled to spring. The carrier includes a tab abutting the top surface in the first position. The abutment of the tab and the top surface retains the spring in the first position. The tab is aligned with the slot in the second position.
Disclosed herein are system, method, and computer program product embodiments for calculating accurate doses for medication using improved user interface features that may be implemented as part of an application operating within a continuous glucose monitoring system. The disclosed interface provides an improved user experience when a medication delivery device is disconnected or does not have the ability to query the requisite data.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
Disclosed herein are system, method, and computer program product embodiments for generating personalized user interface elements for an evolving medical user interface that is in communication with an analyte monitoring system. The evolving medical user interface may be adapted based on a current and/or predicted condition of the user and may be personalized for users of the analyte monitoring system. The disclosed techniques generate personalized user interface elements using trained models that may be specific to the user and/or a population group(s) associated with the user. The disclosed medical user interface is dynamically adjusted based on new data from the user including user analyte data, user medical history data, and/or user activity data.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
Improved graphical user and digital interfaces for analyte monitoring systems are provided. For example, disclosed herein are various embodiments of GUIs including, sensor results, trend alerts, alarms, and insights interfaces. In addition, various embodiments of digital interfaces are described, including methods for sensor activation and pairing, wherein an analyte monitoring software application is configured to pair with a plurality of different types of sensors, and methods data backfilling in an analyte monitoring system, among other embodiments.
System including a transparent sheath (1405) defining a lumen (1418), an optical coherence tomography catheter configured for cardiovascular imaging having an imaging probe (1410) comprising a first end, a second end, and a lens assembly (1420,1430) disposed at the second end of the imaging probe, the imaging probe being configured to transmit light between the first and second ends thereof, and a prosthetic heart valve (THV) disposed about the transparent sheath.
In some embodiments, a method includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon, a handle coupled to the catheter, and a memory for storing data disposed within the handle, recording at least one of part-to-part noise factors and process variation factors and storing it in the memory, calculating an adjusted inflation parameter based on the at least one of part-to-part noise factor and process variation factor, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, and inflating the balloon according to the adjusted inflation parameter.
According to an example of the disclosure, a system for delivering a prosthetic heart valve includes a handle, a delivery catheter extending from the handle, and a balloon on a distal portion of the catheter, the balloon having a proximal portion, a distal portion, and a central portion positioned between the proximal portion and the distal portion, the central portion configured to receive the prosthetic heart valve in a crimped condition thereon. The proximal portion may have a proximal wall thickness, the distal portion may have a distal wall thickness, and the central portion may have a central wall thickness, the central wall thickness being smaller than the proximal wall thickness and smaller than the distal wall thickness.
A method for slowing diabetes development in a diabetic or prediabetic individual or reducing a risk of diabetes development in an individual at risk of developing diabetes comprises administering Bifidobacterium animalis subsp. lactis CECT 8145 (BPL1) and a carbohydrate blend to the individual. The carbohydrate blend comprises a source of at least one carbohydrate that provides rapidly available glucose, a source of at least one carbohydrate that provides slowly available glucose, and a source of at least one non-digestible carbohydrate or resistant starch. A nutritional composition comprises protein, fat, the carbohydrate blend, and BPL1.
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A23L 33/21 - Addition of substantially indigestible substances, e.g. dietary fibres
A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
A61K 31/718 - Starch or degraded starch, e.g. amylose, amylopectin
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
22.
HBV DIAGNOSTIC, PROGNOSTIC, AND THERAPEUTIC METHODS AND PRODUCTS
Provided herein are compositions, systems, and methods for assessing and monitory disease stage and phases, predicting likelihood of disease progression, and predicting and monitoring responses to disease therapies (e.g., in HBV infection).
G01N 33/576 - ImmunoassayBiospecific binding assayMaterials therefor for hepatitis
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
C12Q 1/6837 - Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
23.
TRANSCUTANEOUS SENSOR WITH DUAL ELECTRODES AND METHODS OF DETECTING AND COMPENSATING FOR WITHDRAWAL OF A TRANSCUTANEOUS SENSOR FROM A PATIENT
A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
24.
METHOD AND SYSTEM FOR MONITORING TYPES OF CAPTURE OF A LEADLESS IMPLANTABLE MEDICAL DEVICE
A computer implemented method and system for monitoring types of capture within a distributed implantable system having a leadless implantable medical device (LIMD) to be implanted entirely within a local chamber of the heart and having a subcutaneous implantable medical device (SIMD) to be located proximate the heart are provided. The method is under control of one or more processors of the SIMD configured with program instructions. The method collects far field (FF) evoked cardiac signals following the pacing pulses delivered by the LIMD for an event and analyzes the FF evoked cardiac signals to identify a type of HIS capture as loss of capture (LOC), selective capture, myocardial tissue-only (MT-only) capture, or a non-selective (NS) capture and records a label for the event based on the type of HIS capture identified.
According to an example of the disclosure, a system for delivering a prosthetic heart valve includes a handle, a delivery catheter extending from the handle, and a balloon on a distal portion of the catheter, the balloon having a proximal portion, a distal portion, and a central portion positioned between the proximal portion and the distal portion, the central portion configured to receive the prosthetic heart valve in a crimped condition thereon. The proximal portion may have a proximal wall thickness, the distal portion may have a distal wall thickness, and the central portion may have a central wall thickness, the central wall thickness being smaller than the proximal wall thickness and smaller than the distal wall thickness.
A method of implanting a prosthetic heart valve may include inserting a delivery catheter into a patient's vasculature while the prosthetic heart valve is in a crimped condition on the delivery catheter. The delivery catheter may be advanced through the patient's vasculature until the crimped prosthetic heart valve is positioned within a native valve annulus. While the prosthetic heart valve is within the native valve annulus, a first stage of deployment may be performed in which the balloon is inflated at a first rate of inflation to begin expanding the prosthetic heart valve. After performing the first stage of deployment, a second stage of deployment may be performed in which the balloon is inflated at a second rate of inflation that is greater than the first rate of inflation. After performing the second stage of deployment, the prosthetic heart valve may be anchored within the native valve annulus.
In some embodiments, delivery device includes a delivery catheter, and a handle coupled to the delivery catheter, the handle having a housing and including at least two actuators, each of the at least two actuators being configured to control one of three primary functions, the three primary functions including (1) delivery catheter deflection, (2) delivery catheter axial position fine adjustment, and (3) delivery catheter rotation to achieve native valve commissural alignment.
The present disclosure provides assay cartridges, sliding magnet arrays, system, and methods that may be used for a range of different assays such as immunoassays, nucleic acid analysis, metabolite analysis, clinical chemistry, and complete blood cell count. The assay cartridges or systems optionally contain a sample analysis region to analyze the samples processed in the device. Assay cartridges comprise a first substrate having a first face comprising a pattern of grooves; a second substrate having a first face, wherein the first substrate is positioned in relation to the second substrate such that the first face of the first substrate faces the first face of the second substrate; and a first region and a second region, wherein the first and second regions are defined by the pattern of grooves and are located between the first and second substrates.
The present disclosure provides a dispensing reagent container that is capable of precise small volume reagent dispensing. The dispensing reagent container comprises a proximal end and a distal end; a first storage region at the proximal end having: a first volume, and a first end at a proximal end having an opening for filling with reagent; a second storage region in fluid communication with the first storage region having a second volume, wherein the second volume is less than the first volume, a dispenser positioned at the distal end of the second storage region; and a plunger having a proximal end and a distal end, wherein: the plunger is positioned coaxially within the reagent container spanning the first storage region and the second storage region, and the distal end of the plunger is capable of being in contact with the dispenser at the distal end of the reagent container.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
B01F 35/83 - Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 83/685 - Dispensing two or more contents initially separated and subsequently mixed with at least one of the contents stored in a chamber associated with the dispensing head, e.g. for mixing during dispensing
30.
REDUCING AGENT COMPOSITIONS FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS
The present disclosure relates to compositions for use in the isothermal amplification of nucleic acids in a sample. In particular, the present disclosure provides compositions that include an activator and reducing agent and methods for amplifying at least one target nucleic acid in a sample using the composition. The present disclosure further provides systems and kits for performing such methods and using such compositions.
in vivoin vivo monitoring of an analyte level. In particular, the present invention relates to sensors having saccharides or similar molecules present in glucose-oxidase containing sensing layers to improve sensor stability.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Aspects of the present disclosure provide an analysis cartridge that allows analyzing clinical chemistry or cell types in a fluid sample, such as a blood sample. In certain embodiments, the analysis cartridge comprises a comprehensive metabolic panel (CMP) analysis module. Additional embodiments may further include a complete blood count (CBC) module for analyzing cells. In many embodiments, digital microfluidics (DMF) is used to move samples through the analysis cartridge. Additional embodiments define additional cuvette types and arrangements for detection. Also provided are systems and methods of analyzing fluid samples in the analysis cartridges provided herein.
Described herein are methods for use with an implantable system including at least an atrial leadless pacemaker (aLP). Also described herein are specific implementations of an aLP, as well as implantable systems including an aLP. In certain embodiments, the aLP senses a signal from which cardiac activity associated with a ventricular chamber can be detected by the aLP itself based on feature(s) of the sensed signal. The aLP monitors the sensed signal for an intrinsic or paced ventricular activation within a ventricular event monitor window. In response to the aLP detecting an intrinsic or paced ventricular activation itself from the sensed signal within the ventricular event monitor window, the aLP resets an atrial escape interval timer that is used by the aLP to time delivery of an atrial pacing pulse if an intrinsic atrial activation is not detected within an atrial escape interval.
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
Methods and system to provide glycemic control and therapy management based on monitored glucose data, and current and/or target HbA1C levels are provided.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1495 - Calibrating or testing in vivo probes
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
35.
CARTRIDGES FOR MULTIPLEX ANALYSIS OF ANALYTES AND METHODS OF USING THEM
Aspects of the present disclosure provide an analysis cartridge that allows analyzing multiple chemical components of a sample, such as blood. In certain embodiments, the analysis cartridge comprises a chemical analysis module for analyzing multiple analytes. A chemical analysis module comprises a top panel and a bottom panel and a plurality of channels disposed between the top panel and the bottom panel, wherein one or more channels of the plurality of channels comprise one or more reagents that produce, in each such channel, a detectable signal indicative of the concentration of an analyte. The chemical analysis module can have a sample port that delivers a sample to the plurality of channels and one or more sensors that detect the signals generated in the channels. Also provided herein are methods of analyzing a sample, such as a plasma, serum, or blood sample, in the analysis cartridges provided herein.
In some examples, a method of delivering a prosthetic heart valve includes providing a delivery device having a catheter and an inflatable balloon coupled to the catheter, the inflatable balloon having a plurality of primary folds wrapped around an outer diameter of the inflatable balloon in a first direction, placing a prosthetic heart valve around the inflatable balloon, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, partially inflating the inflatable balloon, and pausing after partially inflating the inflatable balloon and allowing the user to rotate the balloon prior to full inflation.
In some embodiments, delivery device includes a delivery catheter, and a handle coupled to the delivery catheter, the handle having a housing and including at least two actuators, each of the at least two actuators being configured to control one of three primary functions, the three primary functions including (1) delivery catheter deflection, (2) delivery catheter axial position fine adjustment, and (3) delivery catheter rotation to achieve native valve commissural alignment.
An integrated imaging and device deployment platform and method may include a catheter, at least one imaging unit, at least one deployment unit, and at least one device configured to be deployed by the at least one deployment unit. The integrated imaging and device deployment platform facilitates improved navigation and deployment of a therapeutic or medical device by providing the at least one imaging unit proximate the deployment unit. Information generated from the at least one imaging unit may be utilized with additional imaging modalities to provide improved imaging and delivery of devices while reducing use of X-ray radiation and contrast injection.
The present disclosure provides systems and methods for providing neurostimulation therapy according to patient features. The patient features may be analyzed to develop a patient model between physiological and/or patient reported features and optimal settings for a neurostimulation therapy using machine learning operations. The model is used to control ongoing neurostimulation therapy for the patient.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
41.
PACING OUTPUT OPTIMIZATION TO IMPROVE DEVICE LONGEVITY
Disclosed herein are methods for use with an IMD configured to deliver pacing pulses to cardiac tissue, and related systems for use with and/or including an IMD. A method includes determining a pacing impedance of the cardiac tissue, a first capture threshold of the cardiac tissue, and an estimate of a maximum membrane response for the cardiac tissue. Additionally, the method includes using the maximum membrane response to determine an iso-safety factor strength duration curve. The method also includes determining a current or charge drain curve, and determining, based on the iso-safety factor strength duration curve and the current or charge drain curve, a preferred pacing parameter set that includes a preferred pulse width and a preferred pacing amplitude, which provides a specified safety margin.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/375 - Constructional arrangements, e.g. casings
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A catheter includes a multi-lumen catheter shaft that includes a proximal end, a loop portion, and a distal tip. A location system positioned in a first lumen of the shaft includes a distal shaft that extends along at least a portion of the loop, an electromagnetic sensor attached to an outer surface of the distal shaft at a location along the loop, and electromagnetic sensor wires extending proximally from the electromagnetic sensor. The electromagnetic sensor and the pair of electromagnetic sensor wires are positioned along a neutral axis of the multi-lumen catheter shaft. An electrode system includes first and second plurality of electrodes positioned along an outer surface of the loop, a first plurality of wires connected to the first plurality of electrodes and extending through the second lumen, and a second plurality of wires connected to the second plurality of electrodes and extending through the third lumen.
In some examples, a method of delivering a prosthetic heart valve includes providing a delivery device having a catheter and an inflatable balloon coupled to the catheter, the inflatable balloon having a plurality of primary folds wrapped around an outer diameter of the inflatable balloon in a first direction, placing a prosthetic heart valve around the inflatable balloon, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, partially inflating the inflatable balloon, and pausing after partially inflating the inflatable balloon and allowing the user to rotate the balloon prior to full inflation.
A device forms a group of users of a continuous glucose monitor (CGM) service, including creating a database association between identifiers, where each identifier is associated with a different user. The device identifies CGM sensor data for the users, including identifying a portion of the CGM sensor data associated with each user. Each portion of the CGM sensor data was generated by a corresponding CGM sensor and received from a corresponding computing device associated with the user. The device generates a CGM data report from the CGM sensor data, and the CGM data report includes glycemic data for at least two of the users. The device sends the CGM data report to a computing device associated with a user. Upon receipt of the CGM data report, the computing device displays a visual representation of the glycemic data for the subset.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
45.
ABLATION CATHETER WITH SPLIT TIP AND CURRENT DISTRIBUTION
A method of delivering radio-frequency (RF) ablation includes providing a split-tip catheter having a plurality of electrodes and selectively activating one or more of the plurality of electrodes. The method further includes delivering an RF current to activated electrodes and modifying a catheter current delivered to the plurality of electrodes of the split-tip catheter based on a number of activated electrodes.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
46.
REGULATION OF PRESSURE DIFFERENTIALS IN INTERVENTIONAL MEDICAL DEVICES
Devices to minimize the passage of air across a introducer's hemostasis valve when a medical device is inserted therethrough. A kit includes a sheath (12) and a sheath hub (20) attached to the proximal end of the sheath. The sheath hub includes a housing (26), a proximal cap (28) that defines an aperture (29) into the housing, and a hemostasis valve gasket (30) within the housing. The kit also includes a straightener (32) with a cross-section that prevents advancement of the straightener through the aperture of the sheath hub far enough to breach the gasket. The sheath can also include a pressure equalizer configured to equalize a pressure within the sheath lumen ahead of a leading edge of the medical device moving therethrough with a pressure within the sheath lumen behind the leading edge of the medical device moving therethrough without drawing air through the hemostasis valve assembly.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
47.
FLEXIBLE ELECTRICAL COMPONENTS AND MEDICAL DEVICES INCORPORATING THE SAME
e.g.e.g., soldered) to a conductive contact, such as a conductive pill, on an exterior surface of a catheter shaft. The flexible electrode can then be wrapped around the exterior surface of the shaft to form a ring electrode and the bonding layer can be bonded to the catheter shaft, such as by reflow bonding.
In some embodiments, a balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, the collapsible and expandable stent having at least one of an inflow flare and an outflow flare, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a cuff and a plurality of leaflets, the plurality of leaflets defining a noncylindrical profile with a narrowed waist.
The present disclosure provides analyte sensors comprising a sensing layer disposed upon a surface of a first working electrode, wherein the sensing layer comprises an NAD(P)-dependent enzyme and a supply of NAD(P); and a multilayered membrane that overcoats at least a part of the sensing layer and is permeable to an analyte, wherein the membrane comprises at least one layer of negatively charged polymer. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
The present invention relates generally to systems, devices, and methods for in vivo monitoring of an analyte level. In particular, the present invention relates to sensors having saccharides or similar molecules present in glucose-oxidase containing sensing layers to improve sensor stability.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
The present disclosure provides analyte sensors comprising a polymer membrane comprising a calibrant, wherein the polymer membrane overcoats a sensing area and is permeable to a first analyte; wherein the first analyte and the calibrant are different, wherein a first enzyme in the sensing area is capable of electrolyzing both the first analyte and the calibrant; and wherein the calibrant provides a signal at sensor initialization that correlates with sensor activity. The present disclosure also provides methods of detecting a drop in sensitivity of the analyte sensors and methods of manufacturing the analyte sensors.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C08L 39/08 - Homopolymers or copolymers of vinyl-pyridine
G01N 33/487 - Physical analysis of biological material of liquid biological material
In some embodiments, a balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, the collapsible and expandable stent having at least one of an inflow flare and an outflow flare, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a cuff and a plurality of leaflets, the plurality of leaflets defining a noncylindrical profile with a narrowed waist.
An electroporation system is provided. The electroporation system includes a catheter comprising a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a first pulse pattern, and a second pulse pattern that is consecutive to the first pulse pattern, wherein a pulse period defined between a start of the first pulse pattern and a start of the second pulse pattern is in a range from 1 millisecond (ms) to 100ms, such that the waveform facilitates increasing lesion depth.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable application software for use by patients, caregivers and health care professionals to track, view, and share data to support the management of heart failure. Providing a web application featuring technology enabling users to remotely view, monitor, operate and control patient care and medical systems for the management of heart failure.
Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, also disclosed are methods of outcome in subjects suffering from a mild TBI.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
The invention provides methods for determining whether a subject suspected of having a myocardial infarction is experiencing a Type I or Type II myocardial infarction. In particular, systems and methods are provided that employ a probability score based on decision tree based algorithms to process a subject's sex, age, and cardiac troponin concentration(s) and subject's galectin-3 (Gal-3) concentration.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
60.
METHODS AND DEVICES FOR ANALYTE MONITORING CALIBRATION
Systems, methods and apparatus are provided, including one or more processors configured to detect a sensor calibration start event, determine outputs of one or more physiological models based on a plurality of parameters, the plurality of parameters including glucose data and insulin information, determine whether the outputs fall within a predetermined threshold, and in response to determining that the outputs fall within the predetermined threshold, execute a calibration routine.
Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 33/487 - Physical analysis of biological material of liquid biological material
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
62.
SYSTEMS, DEVICES, AND METHODS FOR EPISODE DETECTION AND EVALUATION WITH INTERVENTION GUIDES, ACTION PLANS AND/OR SCHEDULING INTERFACES
Systems, devices, and methods are provided that allow detection of episodes in analyte measurements and the prompting of a subject to self-report possible causes for the episodes and take action in response to episode detection. Correlation of possible causes with detected episodes assists patient behavior modification to reduce the occurrence of episodes. Also provided is function and structure for associating episodes with visits between the subject and a Health Care Provider (HCP) and scheduling interfaces and reports for assisting the HCP in advising numerous patients.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
An implantable biostimulator has fixation tines. A housing of the biostimulator has a longitudinal guide. A frame of the biostimulator movably engages the longitudinal guide. Fixation tines are at a distal end of the frame. Other embodiments are also described and claimed.
An implantable medical device (IMD) for managing therapy is provided that can include a lead with an electrode, a memory configured to store program instructions and one or more processors. The one or more processors can be configured to execute the program instructions to determine a sensed right atrium (RAs) event or a paced right atrial (RAp) event (RAs,p event), determine a sensed right ventricle (RVs) event by detecting a cardiac activity (CA) signal reaches a threshold amplitude and determining a maximum amplitude in a determined period of time after the CA signal reaches the threshold amplitude, and determine an RAs,p-RVs interval between the RAs,p event and RVs event. The one or more processors can also be configured to calculate an atrioventricular delay (AV) delay based on the RAs,p-RVs interval, and manage therapy, provided by the IMD, based on the AV delay that is calculated.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
65.
MEDICAL TOOL EMPLOYING A WARNING MECHANISM NOTIFYING THAT A ROTATIONAL LIMIT HAS BEEN REACHED
A medical tool includes a rotation mechanism that further includes a warning feature. The warning feature provides an indication when the rotation mechanism has achieved a number of rotations.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A system and method are provided for managing atrial-ventricular (AV) delay adjustments. An AV interval is measured that corresponds to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event. A candidate AV delay is set based on the AV interval and a bundle branch adjustment (BBA) value. A QRS characteristic of interest (COI) is measured while utilizing the candidate AV delay in connection with delivering a pacing therapy. The BBA value is adjusted and the candidate AV delay is reset based on the BBA value as adjusted. A collection of QRS COIs and corresponding candidate AV delays are obtained and one of the candidate AV delays is selected as a BBA AV delay. The pacing therapy is managed, based on the BBA AV delay.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
An electrical connector for a catheter includes a plug portion and a receptacle portion. The plug portion includes a plug body, a plurality of holes formed in the plug body, a plurality of electrically-conductive connector pins recessed within the plurality of holes, and a poka-yoke structure. The receptacle portion includes a receptacle body, a plurality of electrically-insulative hollow posts extending from the receptacle body, a plurality of electrically-conductive connector pins, each being partially disposed within and partially disposed outside of a respective hollow post, and a complementary poka-yoke structure. The poka-yoke structures cooperate to facilitate proper alignment of the electrically-conductive connector pins when the receptacle portion is connected to the plug portion.
In some embodiments, a prosthetic heart valve includes a stent having a plurality of commissure attachment features, each of the plurality of commissure attachment features having an arch shape formed by a single continuous strut, a cuff coupled to the stent, a plurality of swatches, each of the plurality of swatches being coupled to each of the plurality of commissure attachment features, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality leaflets having two leaflet attachment regions, the leaflet attachment regions being coupled to a respective one of the plurality of swatches.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
69.
SYSTEMS AND METHODS FOR PULSED FIELD ABLATION WITH INCREASED PULSE PERIODS
An electroporation system is provided. The electroporation system includes a catheter comprising a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a first pulse pattern, and a second pulse pattern that is consecutive to the first pulse pattern, wherein a pulse period defined between a start of the first pulse pattern and a start of the second pulse pattern is in a range from 1 millisecond (ms) to 100 ms, such that the waveform facilitates increasing lesion depth.
Systems for catheter splines are disclosed herein. A catheter spline includes a body made of a superelastic conductive metal material, an insulating polymer jacket made of one or more chemically compatible polymer materials in layers, and an organosilane coupling material coupling the superelastic conductive metal material to the insulating polymer jacket. A catheter includes at least two catheter splines configured in forming a polymer-insulated basket structure with a plurality of individual electrodes and/or an electrode basket structure with splines being relatively large electrodes themselves.
In some examples, a prosthetic heart valve includes a stent having a plurality of commissure attachment features, a cuff coupled to the stent, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality of leaflets having two leaflet attachment tabs, a free edge and an attached edge opposite the free edge, each of the plurality of leaflets having a first region with a first stress response characteristic and a second region with a second stress response characteristic.
Embodiments described herein include an analyte monitoring device for receiving data in an analyte monitoring system. The analyte monitoring device includes a microprocessor, one or more communications integrated circuits electrically coupled to the microprocessor, wherein the one or more communications integrated circuits are further electrically coupled to at least one respective antenna, an input-output (IO) expander electrically coupled to the microprocessor, and one or more storage memories comprising instructions that, when operable by the microprocessor, cause the microprocessor to receive analyte data from a sensor control device of an analyte sensor in the analyte monitoring system. The IO expander increases an amount of pins of the microprocessor.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G01N 33/487 - Physical analysis of biological material of liquid biological material
In some embodiments, a prosthetic heart valve includes a stent having a plurality of commissure attachment features, each of the plurality of commissure attachment features having an arch shape formed by a single continuous strut, a cuff coupled to the stent, a plurality of swatches, each of the plurality of swatches being coupled to each of the plurality of commissure attachment features, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality leaflets having two leaflet attachment regions, the leaflet attachment regions being coupled to a respective one of the plurality of swatches.
In some examples, a prosthetic heart valve includes a stent having a plurality of commissure attachment features, a cuff coupled to the stent, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality of leaflets having two leaflet attachment tabs, a free edge and an attached edge opposite the free edge, each of the plurality of leaflets having a first region with a first stress response characteristic and a second region with a second stress response characteristic.
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
A61B 5/151 - Devices for taking samples of blood specially adapted for taking samples of capillary blood, e.g. by lancets
A61B 5/157 - Devices for taking samples of blood characterised by integrated means for measuring characteristics of blood
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
76.
METHODS, DEVICES, AND SYSTEMS FOR PHYSIOLOGICAL PARAMETER ANALYSIS
A method of calculating at least one physiological parameter using a reticulocyte production index (RPI) value can include: measuring a plurality of first glucose levels over a first time period; measuring a first glycated hemoglobin (HbA1c) level corresponding to an end of the first time period; measuring the RPI value; calculating a red blood cell elimination constant (kage) based on the RPI value; and calculating the at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), and an apparent glycation constant (K), based on (1) the plurality of first glucose levels, (2) the first HbA1c level, and (3) the kage. Further, one or more related analyses (e.g., personalized-target glucose range, personalized-target average glucose, cHbA1c, and the like) can be estimated and/or adjusted based on the at least one physiological parameter.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
77.
BIOSTIMULATOR TRANSPORT SYSTEM HAVING ROTATIONALLY COUPLED SHAFTS
A biostimulator transport system includes an input shaft and an output shaft. The input shaft extends distally to an input gear. The output shaft extends proximally from an output gear to a biostimulator coupling. The output gear is rotationally coupled to the input gear such that rotation of the input shaft drives rotation of the biostimulator coupling. Other embodiments are also described and claimed.
Computer implemented methods and systems for detecting noise in cardiac activity are provided. The method and system obtain a far field cardiac activity (CA) data set that includes far field CA signals for a series of beats, overlay a segment of the CA signals with a noise search window, and identify turns in the segment of the CA signals. The method and system determine whether the turns exhibit a turn characteristic that exceed a turn characteristic threshold, declare the segment of the CA signals as a noise segment based on the determining operation, shift the noise search window to a next segment of the CA signal and repeat the identifying, determining and declaring operations; and modify the CA signals based on the declaring the noise segments.
A valve bypass tool, and a biostimulator transport system having such a valve bypass tool, is described. The valve bypass tool includes an annular seal to seal against a protective sheath of the biostimulator transport system. The valve bypass tool is slidably mounted on the protective sheath and includes a bypass sheath to insert into an access introducer. The valve bypass tool can lock onto the access introducer by mating a locking tab of the valve bypass tool with a locking groove of the access introducer. The locking tab can have a detent that securely fastens the components to resist decoupling when the biostimulator transport system is advanced through the access introducer into a patient anatomy. Other embodiments are also described and claimed.
A multi-electrode assembly of the present disclosure includes a plurality of electrodes; and an electrode support member; wherein a portion of the electrode support member is adapted to selectively ablate a tissue in contact therewith, and at least a portion of the electrodes are configured and arranged on the electrode support member to detect electrophysiological characteristics of the tissue. The electrode support member can be constructed of flexible material and shaped to facilitate contact with certain anatomical structures (e.g., linear, loop, spiral, planar array, or basket shapes). Embodiments described enable selective activation of the electrode support member for ablation and selective activation of electrodes for electrophysiological mapping and/or ablation.
A prosthetic heart valve delivery device may include a handle, an outer shaft coupled to the handle, an inner shaft, and a distal sheath that forms a compartment with the inner shaft, the compartment sized to receive the prosthetic heart valve in a collapsed condition therein, the distal sheath being axially translatable relative to the inner shaft. A first bearing member may be (i) axially and rotationally fixed to the outer shaft and (ii) rotatable relative to the distal sheath. A second bearing member may be (i) axially and rotationally fixed to the distal sheath and (ii) rotatable relative to the outer shaft. The inner shaft may be operably coupled to an actuator of the handle so that actuation of the actuator rotates the inner shaft about a central longitudinal axis of the inner shaft.
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
The present invention generally relates to expandable catheters for use in electrophysiology, and more specifically to high-density balloon catheters for use in diagnosing and/or treating cardiac arrhythmias. A catheter includes an elongate catheter shaft comprising a proximal end and a distal end. The elongate catheter shaft defines a longitudinal axis. The catheter includes an expandable assembly having a first delivery configuration and a second deployed configuration. The balloon member includes at least one flexible framework disposed between an outer facing layer and an inner facing layer of the top surface and/or the bottom surface of the balloon member and at least one plurality of electrodes patterned onto the flexible framework. In some embodiments, a flat balloon member includes electrodes on both sides of the planar balloon member. The balloon member may include a flexible structural element disposed within the interior cavity.
The present disclosure provides systems and methods for detecting leakage currents in radio-frequency (RF) ablation systems. An RF generator may be configured to disable an electrical return path from a patient to a ground terminal. The RF generator may also be configured to apply an electrical signal to an electrode that is positioned to be in proximity to target tissue of the patient. The RF generator may be further configured to measure a leakage impedance while the electrical return path is disabled and the electrical signal is applied to the electrode. The RF generator may also be configured to control RF ablation therapy based, at least in part, on the measured leakage impedance. Other features are also claimed and described.
A61B 18/16 - Indifferent or passive electrodes for grounding
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A biostimulator includes a housing, an electrode extension, and an expandable frame. The housing has a longitudinal axis and an electronics compartment containing pacing circuitry. The electrode extension extends distally between the housing and an electrode. The biostimulator includes an expandable frame including several struts disposed about the longitudinal axis. Other embodiments are also described and claimed.
A biostimulator, such as a leadless cardiac pacemaker, including coaxial fixation elements to engage or electrically stimulate tissue, is described. The coaxial fixation elements include an outer fixation element extending along a longitudinal axis and an inner fixation element radially inward from the outer fixation element. One or more of the fixation elements are helical fixation elements that can be screwed into tissue. The outer fixation element has a distal tip that is distal to a distal tip of the inner fixation element, and an axial stiffness of the outer fixation element is lower than an axial stiffness of the inner fixation element. The relative stiffnesses are based on one or more of material or geometric characteristics of the respective fixation elements. Other embodiments are also described and claimed.
The present disclosure provides a device that may be used for a range of different assays such as immunoassays, nucleic acid analysis, metabolite analysis, clinical chemistry, and complete blood cell count. The device optionally contains a sample analysis region to analyze the samples processed in the device. The device comprises a top substrate bound to a bottom substrate wherein the top substrate bound to the bottom substrate forms two or more primary zones separated by one or more secondary zones, and wherein the top substrate has an opening in one or more of the primary zones.
Systems, devices and methods are provided for power-efficient wireless communications between electronic devices. In particular, the embodiments disclosed herein can reduce battery consumption in a transmitting electronic device and enhance data integrity of data received by a receiving electronic device. According to the embodiments, a first electronic device transmits advertising packets according to a wireless communications protocol, wherein the advertising packets include a first payload data. In response to receiving the advertising packets, a second electronic device can transmit a scan request to the first electronic device which, in turn, terminates the transmission of advertising packets.
Systems, devices, and methods for detecting and measuring meal impact and/or an amount of time an individual is within a predetermined analyte range based on analyte measurements. These results and related information are presented to the individual to show the individual an analyte response associated with consumed meals, or change in an analyte level within a predetermined time period after meals are consumed. These results can be organized based on a ranking or scoring system so as to allow the individual to visualize analyte responses and range impact associated with the meals. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related analyte response.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
In some embodiments, a balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a plurality of leaflets, and a pleated outer cuff having a plurality of shape-set pleats, the pleated outer cuff being coupled to the collapsible and expandable stent at positions between the plurality of shape-set pleats.
Systems, apparatus, articles of manufacture, and methods are disclosed directed to a laboratory diagnostic automation system comprising: interface circuitry; a track to receive and transport receptacles for biological samples; machine-readable instructions; and at least one processor circuit to be programmed by the machine-readable instructions to: determine a throughput state of a medical diagnostic system, determine a processing priority associated with a biological sample to be processed by the laboratory diagnostic automation system as either a first processing priority or a second processing priority; cause dispatch of the biological sample for processing by the laboratory diagnostic automation system based on the processing priority; and cause dispatch of the biological sample for processing by the laboratory diagnostic automation system based on the throughput state.
The present disclosure provides a device that may be used for a range of different assays such as immunoassays, nucleic acid analysis, metabolite analysis, clinical chemistry, and complete blood cell count. The device optionally contains a sample analysis region to analyze the samples processed in the device. The device comprises a top substrate bound to a bottom substrate wherein the top substrate bound to the bottom substrate forms two or more primary zones separated by one or more secondary zones, and wherein the top substrate has an opening in one or more of the primary zones.
The present disclosure provides devices and methods for separation of capture particles into wells of an array of wells and sealing the wells with a hydrophobic liquid. In certain embodiments, the methods of the present disclosure involve detecting presence of a signal from the array of wells, wherein the presence of the signal is indicative of the presence of an analyte immobilized on capture particles. In certain embodiments, the device for separation of capture particles into wells of an array of wells and sealing the wells with a hydrophobic liquid includes protrusions at an opening configured to prevent the hydrophobic liquid from reaching the opening before the hydrophilic liquid is removed.
The present disclosure relate to methods and fluorogenic substrates for analysis of analyte(s) in a sample. The methods include detecting presence of an analyte of interest on capture particles by contacting the capture particles present in nano-chambers with a fluorogenic substrate. The fluorogenic substrate may be of formula (I): (I) wherein: X is selected from a group consisting of H+, K+, Ca2+, tris, triethylammonium, or any other cation; Y is selected from a group consisting of diphosphate, triphosphate, oxymethyl phosphate, or phosphate.
The present disclosure describes lactate-responsive sensors, sensing systems incorporating a lactate-responsive sensor, and methods of use thereof that would be beneficial for continuously monitoring lactate levels and determining lactate thresholds (both aerobic and anaerobic thresholds). The present disclosure also relates to an analyte sensor for continuously detecting glucose and lactate levels.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
97.
METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM
Techniques for data processing and control for a glucose monitoring system are provided, including obtaining a first sensitivity of a glucose sensor; obtaining a second sensitivity of the glucose sensor; comparing a difference between the first sensitivity and the second sensitivity to a predetermined range of values; if the difference is outside the predetermined range of the values, causing a calibration routine for the glucose sensor to be performed; and if the difference is within the predetermined range of values determining a composite sensitivity for a current calibration of the glucose sensor based on the first sensitivity and the second sensitivity and calculating the glucose level based on the current calibration of the glucose sensor.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1495 - Calibrating or testing in vivo probes
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A catheter system for retrieving a leadless cardiac pacemaker from a patient is provided. The cardiac pacemaker can include a docking or retrieval feature configured to be grasped by the catheter system. In some embodiments, the retrieval catheter can include a snare configured to engage the retrieval feature of the pacemaker. The retrieval catheter can include a torque shaft selectively connectable to a docking cap and be configured to apply rotational torque to a pacemaker to be retrieved. Methods of delivering the leadless cardiac pacemaker with the delivery system are also provided.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, medicines for human purposes; sanitary
preparations for medical use; dietetic foods and substances
for medical use; nutraceutical preparations for therapeutic
or medical use; dietary supplements; vitamin preparations;
plasters, materials for dressings.
100.
PURIFICATION OF NUCLEIC ACIDS USING COPPER-TITANIUM OXIDES
The present disclosure relates to systems and methods for purifying nucleic acid. In particular, the present disclosure relates to systems and methods for purifying nucleic acids using metal or metal oxide compositions.
