A system and method to extend a dynamic range of fluorescence measurements. The system includes a neutral density filter stack apparatus including a plurality of neutral density filters. The neutral density filter stack modulates the intensity of light from a source. This modulation improves the ability to detect emissions from a wider-range of fluorophore concentrations, specifically addressing inner-filter effects at higher concentrations that would normally require sample dilution. It can be used in a system in which absorbance and fluorescence measurements are carried out, wherein the intensity of the light source is modulated with the apparatus for the fluorescence measurements. In this hybrid system, the stack modulates the intensity of the excitation light source for fluorescence measurements to be made at very low concentrations of analyte. The hybrid system also includes optics for absorbance measurements to be made at concentrations of analyte that are higher than those detected by fluorescence.
A system and method to extend a dynamic range of fluorescence measurements. The system includes a neutral density filter stack apparatus including a plurality of neutral density filters. The neutral density filter stack modulates the intensity of light from a source. This modulation improves the ability to detect emissions from a wider-range of fluorophore concentrations, specifically addressing inner-filter effects at higher concentrations that would normally require sample dilution. It can be used in a system in which absorbance and fluorescence measurements are carried out, wherein the intensity of the light source is modulated with the apparatus for the fluorescence measurements. In this hybrid system, the stack modulates the intensity of the excitation light source for fluorescence measurements to be made at very low concentrations of analyte. The hybrid system also includes optics for absorbance measurements to be made at concentrations of analyte that are higher than those detected by fluorescence.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
3.
METHODS AND SYSTEMS FOR CHARACTERIZING CELL ADHESION
Systems and methods for using machine-learned models to characterize cell adhesion are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
Systems and methods for using machine-learned models to characterize cell colonies are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
5.
METHODS AND SYSTEMS FOR CLASSIFYING CELL COLONY HEALTH
Systems and methods for using machine- learned models to characterize cell colonies are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
Systems and methods for using machine-learned models to characterize cell adhesion are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
7.
Methods and Systems for Classifying Induced Pluripotent Stem Cell Colonies
Systems and methods for using machine-learned models to characterize cell colonies are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
8.
Methods and Systems for Classifying Cell Colony Health
Systems and methods for using machine-learned models to characterize cell colonies are disclosed. In some embodiments, a machine-learned model includes a first model and, optionally, a second model. A first model may be a convolutional neural network for segmenting images. A second model may be a decision-tree-based and/or ensemble model, such as a random forest model, for example for grading cells or one or more cell cultures. Input for a second model may be based on output from a first model. Timepoint may also be used as an input to a first model and/or second model. Multi-frame images may be used as input to a machine-learned model. In some embodiments, each frame of a multi-frame image is input on a different input channel to a machine-learned model. Decisions about whether to continue culturing or not may be made based on characterization made using a machine-learned model.
09 - Scientific and electric apparatus and instruments
Goods & Services
Downloadable software for scientific instruments and apparatus for verifying the calibration of liquid delivery and for measuring the light absorption properties of liquids.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Cell growth media for growing cells for scientific and research use; cell culture media for scientific and research use; cell culture media for laboratory use. Cell growth media for growing cells for medical or clinical use; cell culture media for medical or clinical use.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Cell growth media for growing cells for scientific and research use; cell culture media for scientific and research use; cell culture media for laboratory use. Cell growth media for growing cells for medical or clinical use; cell culture media for medical or clinical use.
09 - Scientific and electric apparatus and instruments
Goods & Services
downloadable software for scientific instruments and apparatus for verifying the calibration of liquid delivery and for measuring the light absorption properties of liquids
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Cell growth medica being media for growing cells for scientific and research use; cell culture media for scientific and research use; cell culture media for laboratory use, other than for medical or veterinary purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Cell growth medica being media for growing cells for scientific and research use; cell culture media for scientific and research use; cell culture media for laboratory use, other than for medical or veterinary purposes
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service (SaaS) services featuring software for use in cell line database management; software as a service (SaaS) services featuring software to collect, evaluate, manage, and report on biopharmaceutical cell line development; software as a service (SaaS) services featuring software for predicting cell attributes; software as a service (SaaS) services featuring software for predictive analytics; software as a service (SaaS) services featuring software using artificial intelligence for machine learning and predictive analysis.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific apparatus and instruments for use in biopharmaceutical cell development and analysis; cell measuring apparatus and instruments for laboratory and research use; cell counting apparatus and instruments for laboratory and research use; laboratory and scientific equipment, namely, titer plates and cell counting slides. Medical apparatus and instruments for use in biopharmaceutical cell development and analysis; cell measuring apparatus and instruments for medical use; cell counting apparatus and instruments for medical use; medical device, namely, titer plates and cell counting slides; all the aforementioned goods not in relation to the dental field.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service (SaaS) services featuring software for use in cell line database management; software as a service (SaaS) services featuring software to collect, evaluate, manage, and report on biopharmaceutical cell line development; software as a service (SaaS) services featuring software for predicting cell attributes; software as a service (SaaS) services featuring software for predictive analytics; software as a service (SaaS) services featuring software using artificial intelligence for machine learning and predictive analysis
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific apparatus and instruments, namely, cell analyzer for use in biopharmaceutical cell development and analysis; cell measuring apparatus and instruments for laboratory and research use; cell counting apparatus and instruments, namely, cell attribute analyzer for laboratory and research use; laboratory and scientific equipment, namely, titer plates for growing cells and cell counting microscope slides Medical apparatus and instruments for use in biopharmaceutical cell development and analysis; cell measuring apparatus and
instruments for medical use; cell counting apparatus, namely, cell attribute analyzer and instruments for medical use; medical
devices, namely, titer plates for growing cells and cell counting microscope slides for medical use; all the aforementioned goods not in relation to the dental field
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Calibration and quality control fluids for osmometers; calibration and quality control fluids for cryoscopes; calibration and quality control fluids for bilirubinometers; calibration and quality control fluids for fluorometers; catalysts for use in the cultivation of anaerobic bacteria; reagents used for counting cells in body fluids in the field of hematology for non-medical purposes; laboratory reagents for research and evaluation purposes for staining raw milk cells; laboratory reagents for preservation of bulk tank and individual cow milk samples for testing; enzymes, namely, alkaline phosphatases. Catalysts for use in the cultivation of anaerobic bacteria for medical use; medical diagnostic reagents for the analysis of body fluids, namely, for counting cells in body fluids and in the field of hematology; biocides for the preservation of bulk tank and individual cow milk samples for laboratory testing.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Calibration and quality control fluids for osmometers; calibration and quality control fluids for cryoscopes; calibration and quality control fluids for bilirubinometers for diagnostic, scientific, and research purposes; calibration and quality control fluids for fluorometers; catalysts for use in the cultivation of anaerobic bacteria; reagents used for counting cells in body fluids in the field of hematology for non-medical purposes; laboratory reagents for research and evaluation purposes for staining raw milk cells; preservation of bulk tank and individual cow milk samples for non-medical testing; enzymes, namely, alkaline phosphatases for preservation of bulk tank and individual cow milk samples for non-medical testing Catalysts for use in the cultivation of anaerobic bacteria for medical use; medical diagnostic reagents for the analysis of body fluids, namely, for counting cells in body fluids and in the field of hematology; biocides for the preservation of bulk tank and individual cow milk samples for laboratory testing Laboratory equipment, namely, osmometers for non-medical purposes; laboratory equipment, namely, cryoscopes for non-medical purposes; laboratory equipment, namely, bilirubinometers for non-medical purposes; laboratory equipment, namely, fluorometers for non-medical purposes; laboratory equipment, namely, cell counters; laboratory equipment, namely, apparatus for cultivation of bacteria; laboratory equipment, namely, programmable fluid dispensers for use in the field of depositing samples containing microbes onto plates; laboratory diagnostic equipment, namely, assay plates, cartridges for holding laboratory samples, petri dishes, pipets, tubes, specimen transport containers, anaerobic jars and coagulation timers Medical diagnostic instruments, namely, osmometers for medical purposes; medical diagnostic instruments, namely, osmometers for medical purposes; medical diagnostic instruments, namely, cryoscopes for medical purposes; medical diagnostic instruments, namely, bilirubinometers for medical purposes; medical diagnostic instruments, namely, fluorometers for medical purposes; medical diagnostic instruments for analyzing body fluids, namely, cell counters; medical diagnostic instruments, namely, assay plates, cartridges for holding medical samples, petri dishes, pipets, tubes, specimen transport containers, anaerobic jars and coagulation timers
A plug for an osmometry sample cup or vial is provided that seals the sample cup or vial to prevent significant evaporation of a sample solution in the cup or vial prior to obtaining an osmolality measurement.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Catalysts for scientific and research use; catalysts for use in the cultivation of anaerobic bacteria Catalysts for medical use; catalysts for use in the cultivation of anaerobic bacteria for medical use
A blood plasma separation system is provided using a cuvette including a semipermeable membrane to exclude red blood cells and white blood cells from an outlet side while permitting passage of plasma. The cuvette includes a collection surface adjacent the outlet side of the membrane and a sample chamber in fluid communication with the collection surface to receive plasma. The cuvette can be spun in a rotor system to draw the plasma into the sample chamber for further testing. The rotor system can include an optical detection assembly for optically testing plasma in the sample chamber in the cuvette while in the rotor system. The rotor system can include a plasma retrieval assembly for withdrawing plasma from the sample chamber for testing outside of the cuvette.
A plug for an osmometry sample cup or vial is provided that seals the sample cup or vial to prevent significant evaporation of a sample solution in the cup or vial prior to obtaining an osmolality measurement.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical and biochemical reagents used for counting cells in body fluids and in the field of hematology for non-medical purposes Medical diagnostic reagents for the analysis of body fluids, namely, for counting cells in body fluids and in the field of hematology Laboratory instruments for counting cells in body fluids and in the field of hematology for non-medical purposes; cartridges for use with laboratory instruments for analyzing body fluids, namely, for counting cells in body fluids and in the field of hematology for non-medical purposes Medical diagnostic instruments for analyzing body fluids, namely, for counting cells in body fluids and in the field of hematology; cartridges for use with medical diagnostic instruments for analyzing body fluids, namely, for counting cells in body fluids and in the field of hematology
09 - Scientific and electric apparatus and instruments
Goods & Services
Scientific apparatus, namely, osmometers used for determining osmotic pressure of liquid samples for in-vitro diagnostic, pharmaceutical and industrial applications
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
programmable electronic control units for the automatic generation, regulation, and monitoring of anaerobic and/or microaerobic environments for microorganism culturing, and culture jars, vacuum pumps, hoses, and gas regulators all sold as a unit for laboratory uses programmable electronic control units for the automatic generation, regulation, and monitoring of anaerobic and/or microaerobic environments for microorganism culturing, and culture jars, vacuum pumps, hoses, and gas regulators all sold as a unit for medical uses
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
LABORATORY REAGENTS FOR SCIENTIFIC USE AND CHEMICAL PRESERVATIVES FOR FOOD, NAMELY, PRESERVATION OF BULK TANK AND INDIVIDUAL COW MILK SAMPLES FOR LABORATORY TESTING BIOCIDES FOR THE PRESERVATION OF BULK TANK AND INDIVIDUAL COW MILK SAMPLES FOR LABORATORY TESTING
