Abstract

Disclosed are a tricyclic compound, and a preparation method therefor and the use thereof. The tricyclic compound has a structure as shown in formula I, and can be used for treating various mental diseases and neurodegenerative diseases such as schizophrenia, depression and Parkinson's disease. Disclosed are a tricyclic compound, and a preparation method therefor and the use thereof. The tricyclic compound has a structure as shown in formula I, and can be used for treating various mental diseases and neurodegenerative diseases such as schizophrenia, depression and Parkinson's disease.

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems
• A61K 31/4355 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/538 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
• A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• C07D 487/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

A poly(β-amino ester) compound, a composition comprising same and a use thereof, and in particular, a compound as shown in a formula I or a pharmaceutically acceptable salt thereof. The compound as shown in formula I can be used for preparing a delivery system. The prepared delivery system is capable of delivering a nucleic acid drug, and can be used for delivering a nucleic acid prophylactic and/or therapeutic agent to the lung and/or liver.

IPC Classes  ?

• C08G 73/02 - Polyamines
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

Provided are fusion proteins and related molecules useful for conducting RNA editing specifically at the target RNA molecules, with little or no off-target editing. The fusion protein may include an RNA-specific adenosine deaminase or a deaminase domain thereof such as ADAR2dd, cleavably linked to an inhibitory domain of a cytidine deaminase, such as APOBEC. The inhibitory domain of a cytidine deaminase is capable of inhibiting the activity of an RNA adenosine deaminase. Before being recruited by the guide RNA, the RNA-specific adenosine deaminase within the fusion protein remains inactive. Upon binding to the target RNA molecule, the inhibitory domain can be cleaved by a corresponding protease, allowing the RNA-specific adenosine deaminase to edit the RNA molecule efficiently with reduced or no off-target editing.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/50 - Proteinases

Abstract

2A2A receptor agonistic activity and wide application prospects.

IPC Classes  ?

• C07C 275/26 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present disclosure discloses a monoclonal antibody targeting FZD7, preparation method and use thereof. The monoclonal antibody targeting FZD7 comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises an amino acid sequence of SEQ ID NO: 1 or an amino acid sequence with at least 99% sequence identity to sequence of SEQ ID NO: 1, the light chain variable region comprises an amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 99% sequence identity to sequence of SEQ ID NO: 2. The monoclonal antibody targeting FZD7 obtained by the present disclosure binds to the FZD7 protein both in vitro and in vivo and has clinical development value.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C07K 14/725 - T-cell receptors
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A Cas12 protein and the use thereof. The Cas12 protein has an amino acid sequence having at least 90% sequence identity with a sequence as set forth in SEQ ID NO: 1 or a homologous sequence thereof, and the amino acid sequence of the Cas12 protein is not SEQ ID NO: 1. The Cas12 protein has good thermal stability and trans-cleavage activity, which is beneficial for the storage and transportation of the Cas12 protein in practical applications, increases application scenarios of the Cas12 protein and a CRISPR system based on the Cas12 protein, and provides more choices for users. In addition, on the basis of the existing theoretical foundation of protein engineering, the Cas12 protein mutant with improved thermal stability can also serve as a template/starting sequence for subsequent protein engineering.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/55 - Hydrolases (3)
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

A method for constructing a drosophila strain for site-specific integration of an exogenous gene. In the method, PAI of a large serine recombinase is used to specifically recognize an attP sequence and/or an attB sequence contained in a genome of a drosophila strain, so as to integrate an exogenous gene into a specific location within the genome of the drosophila strain. The amino acid sequence of the PAI is as shown in SEQ ID NO: 1; and/or the large serine recombinase is derived from Pseudomonas aeruginosa.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/54 - Transferases (2)
• C12N 15/12 - Genes encoding animal proteins

Abstract

The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments. The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

IPC Classes  ?

• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61P 35/00 - Antineoplastic agents

Abstract

The use of a sulfonamide compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, or a stereoisomer thereof as a WDR5 inhibitor. The compound has a significant effect as a WDR5 and Myc interaction blocker, and is conducive to cancer treatment. A1and A2are ring structures, and R1and R2 are substituents.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

A sulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, a preparation method for same and a use of same, and a pharmaceutical composition comprising same. The compound serves as a WDR5 inhibitor, has a remarkable effect as a WDR5 and Myc interaction blocker, and is beneficial to cancer treatment. A1and A2each are of a ring structure, and R1and R2 are substituents.

IPC Classes  ?

• C07D 277/36 - Sulfur atoms
• C07D 277/02 - Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
• C07D 333/02 - Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
• C07D 211/92 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
• C07D 265/28 - 1,4-OxazinesHydrogenated 1,4-oxazines
• C07D 267/10 - Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
• C07C 13/00 - Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
• C07C 15/02 - Monocyclic hydrocarbons
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/425 - Thiazoles
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• A61P 35/00 - Antineoplastic agents

Abstract

The provided is a stream processing-based non-blocking oriented FAST and rotated BRIEF (ORB) feature extraction accelerator implemented by a field programmable gate array (FPGA), which mainly includes two innovations: A stream processing-based non-blocking hardware architecture and a cache management algorithm are provided. The accelerator precisely controls and buffers each column of an rBRIEF descriptor computation window by using an algorithm, allowing to receive a new input pixel stream while computing a descriptor, thereby achieving non-blocking processing. An efficient hardware sorting design embedded in an accelerator is provided. Based on a count sorting algorithm, minimal resources are used to implement rBRIEF sorting on hardware, and the rBRIEF sorting is embedded in the accelerator. The accelerator ensures quality of a feature point while achieving high-speed feature point extraction, without significantly reducing accuracy of ORB_SLAM and other algorithms.

IPC Classes  ?

• G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]Salient regional features
• G06T 1/60 - Memory management

Abstract

Disclosed are a thiazolidinedione compound and a pharmaceutical composition and a use thereof. The present invention provides a use of a compound as shown in formula I or a pharmaceutically acceptable salt thereof in the preparation of a DNA methyltransferase 3A inhibitor. The thiazolidinedione compound provided by the present invention has excellent inhibitory activity against the DNA methyltransferase DNMT3A.

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Described herein are methods and non-transitory computer-readable media of a computing system configured to obtain a plurality of images of an object from a plurality of orientations at a plurality of times. A machine learning model is encoded to represent a continuous density field of the object that maps a spatial coordinate to a density value. The machine learning model comprises a deformation module configured to deform the spatial coordinate in accordance with a timestamp and a trained deformation weight. The machine learning model further comprises a neural radiance module configured to derive the density value in accordance with the deformed spatial coordinate, the timestamp, a direction, and a trained radiance weight. The machine learning model is trained using the plurality of images. A three-dimensional structure of the object is constructed based on the trained machine learning model.

IPC Classes  ?

• G06T 7/149 - SegmentationEdge detection involving deformable models, e.g. active contour models
• G06T 9/00 - Image coding
• G06T 15/10 - Geometric effects

Abstract

A method for identifying a cell population passage number. The method comprises: judging the probability of a cell population to be identified being in each of N known passage numbers on the basis of a preset passage number identification model; comparing a characteristic quantity of the cell population to be identified with characteristic quantities of cell populations of N known passage numbers to obtain a passage number range within which the cell population to be identified falls; and obtaining a passage number for the cell population to be identified according to the passage number range within which the cell population to be identified falls and the probability of the cell population to be identified being in each passage number. Further disclosed is a marker set for identifying a cell population passage number.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis

Abstract

Disclosed in the present invention are a thiophene ring compound, a preparation method therefor and an application thereof. The structure of the thiophene ring compound of the present invention is as shown in formula I. The compound of the present invention has good affinity and agonistic activity against at least one of a dopamine receptor and a 5-hydroxytryptamine receptor.

IPC Classes  ?

• C07D 495/16 - Peri-condensed systems
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 25/24 - Antidepressants

Abstract

An image rendering system for rendering two-dimensional images in real-time. The image rendering system can receive an implicit representation model of a three-dimensional image. The image rendering system can construct, based on voxel coordinates, a three-dimensional image based on the implicit representation model. The image rendering system can rotate the three-dimensional image to an orientation in a computing space based on a user input. The image rendering system can generate a two-dimensional image based on the rotated three-dimensional image.

IPC Classes  ?

• G06T 15/08 - Volume rendering
• G06T 9/00 - Image coding
• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts

Abstract

Residual Radiance Field (ReRF), as a highly compact neural representation to achieve real-time FVV rendering on long-duration dynamic scenes. ReRF explicitly models the residual information between adjacent timestamps in the spatial-temporal feature space, with a global coordinate-based compact MLP as the feature decoder. ReRF employs a compact motion grid along with a residual feature grid to exploit inter-frame feature similarities. Also a sequential training scheme to maintain the smoothness and the sparsity of the motion/residual grids. Based on ReRF, a special FVV codec may be designed that achieves three orders of magnitudes compression rate and a companion ReRF player may be implemented to support online streaming of long-duration FVVs of dynamic scenes.

IPC Classes  ?

• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks

Abstract

A method for quantum transport simulation of a device with atomic disorders is provided. The device comprises a central device disposed between a first electrode and a second electrode. The method comprises receiving a set of parameters of the device representing the atomic disorders; defining a non-equilibrium Green's function in Keldysh's 2x2 matrix representation in a global coordinate framework; calculating an averaged Green's function based on an effective medium for the central device; and obtaining averaged quantum transport properties based on the averaged Green's function.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

Abstract

Provided is a Un1Cas12f1-based gene expression regulation system. The gene expression regulation system at least comprises: a mutant Cas12f1-3R of Un1Cas12f1 or a nucleic acid encoding same. Un1Cas12f1-3R includes the following mutations: D143R/T147R/T203R. Un1Cas12f1-3R can bind to transcriptional activators (VPR, miniVPR) to generate miniCRa or bind to transcriptional repressors (KRAB, KRAB-MeCP2, Zim3, Zim3-MeCP2, Dnmt3a3L) to generate miniCRi. By respectively binding miniCRa or miniCRi to a DBD (including: Sso7d, Sac7e, Mse7, or Sto7), SminiCRa or SminiCRi is generated, thus further enhancing the transcriptional regulation capability of SminiCRa or SminiCRi. By modifying the structure of sgRNA, the expression of genes can also be efficiently regulated at multiple sites.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/55 - Hydrolases (3)
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present application provides a fine-grained file system and a file reading and writing method. Corresponding read or write operations are performed on sub-files of one or a plurality of files with read and write needs by means of a double-layer index structure arranged for each file, such that the function of concurrent reading and writing of a single large file is achieved, and the speed and efficiency of file reading and writing are improved.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

Abstract

An efficient base editing system on the basis of a miniature CRISPR Cas protein IscB, wherein IscBn (D61A) of the IscBn-ωRNA editing system has one or more of point mutations D96K/Q99R/S456R/D89R/N462H/S430K/S386R/N384R/F137N, and/or ωRNA of the system thereof has one or more of the mutations, and the amino acid sequence of the IscBn (D61A) is as shown in SEQ ID No.1. The editing system has efficient editing capabilities of ABE, CBE, CGBE and AYBE in human cells.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

Disclosed in the present invention is a GPU-based method for accelerating logical rewriting. The present invention parallelizes the sub-process of AIG rewriting. The recursive sub-process of AIG rewriting is redesigned to be non-recursive in order to provide sufficient parallelism for a GPU. Secondly, in order to parallelize a replacement step on a GPU, the present invention uses a lock to ensure that mutually exclusive access inevitably breaks the scalability of parallelism between nodes. In order to make full use of large-scale inter-node parallelism, the present invention proposes a work scheduler that groups nodes of non-overlapping MFFCs, such that nodes in the MFFC can be deleted simultaneously without conflicts. In order to create and delete the same node at the same time, the present invention further provides a GPU-friendly graphical data structure to support these concurrent operations.

IPC Classes  ?

• G06F 30/327 - Logic synthesisBehaviour synthesis, e.g. mapping logic, HDL to netlist, high-level language to RTL or netlist

Abstract

A computing system for encoding a machine learning model comprises a plurality of layers and a plurality of computation units. A first set of computation units are configured to process data at a first bit width. A second set of computation units are configured to process at a second bit width. The first bit width is higher than the second bit width. A memory is coupled to the computation units. A controller is coupled to the computation units and the memory. The controller is configured to provide instructions for encoding the machine learning model. The first set of computation units are configured to compute a first set of layers and the second set of computation units are configured to compute a second set of layers.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A computer-implemented method of generating editable free-viewport videos is provided. A plurality of video of a scene from a plurality of views is obtained. The scene comprises includes an environment and one or more dynamic entities. A 3D bounding-box is generated for each dynamic entity in the scene. A computer device encodes a machine learning model including an environment layer and a dynamic entity layer for each dynamic entity in the scene. The environment layer represents a continuous function of space and time of the environment. The dynamic entity layer represents a continuous function of space and time of the dynamic entity. The dynamic entity layer includes a deformation module and a neural radiance module. The deformation module is configured to deform a spatial coordinate in accordance with a timestamp and a trained deformation weight. The neural radiance module is configured to derive a density value and a color.

IPC Classes  ?

• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06T 3/02 - Affine transformations
• G06T 7/50 - Depth or shape recovery

Abstract

Disclosed herein are polybenzimidazole or substituted polybenzimidazole polymers comprising repeating units having the structure of Formula (I): as well as compositions thereof. The polymers and compositions of the present disclosure absorb and/or scatter ultraviolet light and are contemplated as useful at least for protecting a keratinous substrate, such as skin, from ultraviolet radiation. Methods of using the disclosed polymers and compositions are also disclosed.

IPC Classes  ?

• A61K 8/37 - Esters of carboxylic acids
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• C08G 73/18 - Polybenzimidazoles
• H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]

Abstract

Disclosed herein are polystyrene, polyacrylate, polyacrylonitrile, polymaleimide, or polymaleic anhydride polymers comprising repeating units having the structure of Formula (I), as well as copolymers and compositions thereof. The polymers, copolymers, and compositions of the present disclosure absorb and/or scatter ultraviolet light and are contemplated as useful for protecting a keratinous substrate, such as skin, from ultraviolet radiation. Methods of using the disclosed polymers, copolymers, and compositions are also disclosed.

IPC Classes  ?

• C08F 8/14 - Esterification

Abstract

A graphics processing unit (GPU)-based logic rewriting acceleration method comprising parallelizing sub-procedures of And-Inverter Graph (AIG)-based logic rewriting. A recursive sub-procedure of the AIG-based logic rewriting is redesigned to be non-recursive, to provide sufficient parallelism for a GPU. In order to parallelize a replacement step on the GPU, the present disclosure uses a lock to ensure mutually exclusive access, which inevitably damages scalability of inter-node parallelism. In order to fully utilize the inter-node parallelism on a large scale, the present disclosure proposes a work scheduler that adds nodes with non-overlapping maximum fan-out-free cones (MFFCs) to a group, such that nodes in an MFFC can be deleted simultaneously without a conflict. In order to simultaneously create and delete a same node, the present disclosure also proposes a GPU-friendly graphical data structure to support these concurrent operations.

IPC Classes  ?

• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

Provided in the present invention are a deep neural network checkpoint optimization system and method based on a nonvolatile memory. A corresponding network structure is registered in a nonvolatile memory by means of a client module and a serving end module before deep neural network training is started, and a data index and a data communication protocol based on remote direct memory access (RDMA) are created; and during a neural network training process, zero-copy asynchronous end-to-end neural network data persistence is provided in the present invention, such that a user can do fine-grained checkpointing without affecting a training speed, thus ensuring fault tolerance and data persistence.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

Disclosed herein are polybenzophenone polyol or substituted polybenzophenone polyol polymers comprising repeating units having the structure of Formula (I), copolymers thereof, as well as compositions thereof. The polymers, copolymers, and compositions of the present disclosure absorb and/or scatter ultraviolet light and are contemplated as useful for protecting a keratinous substrate, such as skin, from ultraviolet radiation. Methods of using the disclosed polymers, copolymers, and compositions are also disclosed.

IPC Classes  ?

• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines
• C08G 59/04 - Polycondensates containing more than one epoxy group per molecule of polyhydroxy compounds with epihalohydrins or precursors thereof
• C08G 59/06 - Polycondensates containing more than one epoxy group per molecule of polyhydroxy compounds with epihalohydrins or precursors thereof of polyhydric phenols

Abstract

Disclosed herein are polymers derived from one or more bis-nucleophilic compounds and comprising repeating units having the structure of Formula: (I), as well as compositions thereof. The polymers and compositions of the present disclosure absorb and/or scatter ultraviolet light and are contemplated as useful for protecting a keratinous substrate, such as skin, from ultraviolet radiation. Methods of using the disclosed polymers and compositions are also disclosed.

IPC Classes  ?

• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/37 - Esters of carboxylic acids
• A61Q 19/04 - Preparations for care of the skin for chemically tanning the skin
• C08G 14/00 - Condensation polymers of aldehydes or ketones with two or more other monomers covered by at least two of the groups
• C08G 16/00 - Condensation polymers of aldehydes or ketones with monomers not provided for in the groups

Abstract

A window-based dynamic scrubbing scheduling method is provided. By dynamically scheduling a user task and a scrubbing task, the method can reduce scrubbing conflicts of a field-programmable gate array (FPGA) scrubbing module and scrub each user task in a timely manner as much as possible. The method greatly reduces area and energy consumption overheads of a hardware circuit, and improves system reliability. The method proposes a negotiation-driven scrubbing scheduling algorithm and an integer linear programming (ILP)-based optimization-driven scrubbing scheduling algorithm. Based on global conflict information, the algorithms in the method can scrub more user tasks and improve the system reliability. The method ensures reliability of a mixed-criticality task set system. The method provides a dynamic voltage and frequency scaling (DVFS)-based multi-Internet Content Adaptation Protocol (ICAP) port allocation algorithm that can explore an impact of FPGA architecture support on the system reliability to further optimize the system reliability.

IPC Classes  ?

• G06F 9/48 - Program initiatingProgram switching, e.g. by interrupt

Abstract

Disclosed is an out-of-order parallel maximum flow\minimum cutting method implemented by a high-energy-efficiency FPGA. In the present invention, a single-layer large two-dimensional trellis diagram is folded into a multi-layer small trellis diagram. The foregoing method has two benefits: folded grid architecture can store and process a trellis diagram having a size much larger than the size of a processor array; and the foregoing architecture also confers upon a two-dimensional processor array a degree of freedom in a vertical direction, so that the processor can utilize the degree of freedom in the vertical direction to improve the parallel potential of the architecture. By means of the folded grid architecture proposed by the present invention, a small-sized processor array has the capability to process a trellis diagram having a size far larger than the small-sized processor array. Moreover, the foregoing folded grid architecture can utilize the axial symmetry of folding to substantially reduce cross-boundary transmission of data in the processor array, thus reducing additional overhead caused by data movement. The present invention further proposes an out-of-order parallel execution technique, which can fully exploit the parallel potential of the folded grid architecture.

IPC Classes  ?

• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]

Abstract

Disclosed in the present invention is a window-based dynamic scrubbing scheduling method. Provided in the present invention is a new window-based dynamic scrubbing scheduling algorithm. By means of dynamically scheduling user tasks and scrubbing tasks, the algorithm disclosed in the present invention can reduce scrubbing conflicts of an FPGA scrubbing module, and scrub all the user tasks in a timely manner as much as possible. Compared with the current method, by means of the method provided in the present invention, the area and energy consumption overheads of a hardware circuit are greatly reduced, and the reliability of a system is improved. Provided in the present invention are a negotiation-driven based scrubbing scheduling algorithm and an ILP-based optimization-driven scheduling algorithm, and by means of the algorithms in the present invention, more user tasks can be scrubbed by using global conflict information, thereby improving the reliability of a system. The present invention ensures the reliability of a mixed criticality task set system. Provided in the present invention is a DVFS-based multi-ICAP port allocation algorithm, by means of which the influence of an FPGA architecture on the reliability of a system can be explored, so as to further optimize the reliability of the system.

IPC Classes  ?

• G06F 30/34 - Circuit design for reconfigurable circuits, e.g. field programmable gate arrays [FPGA] or programmable logic devices [PLD]

Abstract

A computing core for rendering an image computing core comprises a position encoding logic and a plurality of pipeline logics connected in series in a pipeline. The position encoding logic is configured to transform coordinates and directions of sampling points corresponding to a portion of the image into high dimensional representations. The plurality of pipeline logics are configured to output, based on the high dimensional representation of the coordinates and the high dimensional representation of the directions, intensity and color values of pixels corresponding to the portion of the image in one pipeline cycle. The plurality of pipeline logics are configured to run in parallel.

IPC Classes  ?

• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead
• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06T 15/00 - 3D [Three Dimensional] image rendering

Abstract

A disordered parallel maximum flow/minimum cut method implemented by an energy-efficient field-programmable gate array (FPGA) folds a single-layer large two-dimensional grid graph into a multi-layer small grid graph. The method enables a folding grid architecture to store and process a grid graph that is much larger than a processor array in size. The folding grid architecture endows a two-dimensional processor array with a degree of freedom in a vertical direction, such that the two-dimensional processor array can leverage a potential for parallel performance of the folding grid architecture based on the degree of freedom in the vertical direction. The folding grid architecture enables a small-sized processor array to have an ability to process a grid graph that is much larger than the small-sized processor array in size. In addition, based on axial symmetry of folding, the folding grid architecture can greatly reduce cross-boundary transmission of data in the processor array.

IPC Classes  ?

• G06F 30/347 - Physical level, e.g. placement or routing
• G06F 30/392 - Floor-planning or layout, e.g. partitioning or placement
• G06F 111/10 - Numerical modelling
• G06F 115/10 - Processors

Abstract

Described herein are methods and non-transitory computer-readable media configured to obtain a plurality of images from a plurality of image scanning orientations for an object. A rigid registration is performed to the plurality of images to obtain a transformation matrix to normalize the plurality of images from their respective image spaces to a normalized image space. Each normalized image comprises a plurality of voxels. A machine learning model comprising an implicit representation of a high-resolution image is trained using the normalized images, wherein the high-resolution image comprises more voxels than the voxels in the normalized images. The high-resolution image is generated based on the trained machine learning model. The plurality of images are a plurality of anisotropic 2D images, while the high resolution image can be a 2D or 3D high resolution image.

IPC Classes  ?

• G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks
• G06T 3/4053 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution
• G06T 5/10 - Image enhancement or restoration using non-spatial domain filtering
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks

Abstract

Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The present invention provides a middleware system and method for read/write optimization of a scientific data file. The method comprises: receiving a data write request of a user, constructing a spatial grid according to regional mask information written into scientific data, and merging grid data blocks in the same region to construct a continuous non-equal-width data block; performing grouping according to the regional mask information of the continuous non-equal-width data block to obtain grouped non-equal-width data blocks comprising regional grouping information, and coding the grouped non-equal-width data blocks and constructing indexes to obtain coded non-equal-width data blocks comprising index information; and/or retrieving a corresponding data block according to regional reading information of the user and sending a data block reading instruction; reading and writing metadata corresponding to the scientific data; and reading and writing the coded non-equal-width data blocks. According to the present application, by changing the semantics of a read/write request of the user, the objectives of changing a data organization mode of the user and improving data read/write performance are achieved; and the memory footprint of regional data reading is reduced.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 16/31 - IndexingData structures thereforStorage structures
• G06F 16/38 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually

Abstract

Disclosed are a fused ring piperidine compound, and a preparation method therefor and the use thereof. The fused ring piperidine compound is as represented by formula I '. The fused ring piperidine compound has a relatively good anti-depression effect, and has good application prospects.

IPC Classes  ?

• C07D 471/16 - Peri-condensed systems
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 25/24 - Antidepressants

Abstract

An energy-efficient memory for cryogenic computing is provided. The energy-efficient memory includes a plurality of memory banks, where each of the memory banks includes a cryogenic semi-static, dual-port, boost-free gain cell (CSDB-GC) macro module, a universal address decoder, and a different address decoder. The CSDB-GC macro module includes a plurality of columns of local blocks, and each of the local blocks includes a plurality of CSDB-GC memory cells. A final measurement result of a 16 Kb CSDB-eDRAM shows that the 16 Kb CSDB-eDRAM achieves data retention time (DRT) of 16.67 seconds, which is 2.6 times longer than DRT of a state-of-the-art cryogenic eDRAM at a temperature of 4.2 K, and achieves lower refresh power (0.11 pW/Kb). In addition, the 16 Kb CSDB-eDRAM also achieves shorter access time, namely, 710 ps (1.41 GHz). Compared with the state-of-the-art work, the 16 Kb CSDB-eDRAM has a lowest dynamic power consumption overhead, namely, 49.23 uW/Kb.

IPC Classes  ?

• G11C 11/402 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells with charge regeneration individual to each memory cell, i.e. internal refresh
• G11C 11/408 - Address circuits
• G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating
• G11C 11/4096 - Input/output [I/O] data management or control circuits, e.g. reading or writing circuits, I/O drivers or bit-line switches

Abstract

The present application provides a method for detecting infertile spermatozoa in a sample, the method comprising: detecting a concentration of at least one metal in the sample that falls outside of a predetermined range using single cell inductively coupled plasma mass spectrometry (sc-ICP-MS). It also provides a method for detecting infertile spermatozoa in a sample, which comprising: detecting a dynamic or kinetic parameter of a signal spike of at least one metal selected from the group of several metallic elements by sc-ICP-MS.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• H01J 49/10 - Ion sourcesIon guns

Abstract

An efficient K-nearest neighbor (KNN) method for a single-frame point cloud of a LiDAR and an application of the efficient KNN method for the single-frame point cloud of the LiDAR are provided, where the efficient KNN method for the single-frame point cloud of the LiDAR is accelerated by a field-programmable gate array (FPGA). In the efficient KNN method for the single-frame point cloud of the LiDAR, a data structure is established based on point cloud projection and a distance scale. The data structure ensures that adjacent points in space are organized in adjacent memories. A new data structure is efficiently constructed. An efficient nearest point search mode is provided.

IPC Classes  ?

• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G06T 7/70 - Determining position or orientation of objects or cameras

Abstract

Disclosed in the present invention is a high-efficiency memory used for cryogenic computing, characterized by comprising a plurality of memory groups. Each memory group comprises a CSDB-GC macro module, a universal address decoder and a different address decoder, the CSDB-GC macro module comprising a plurality of columns of local blocks, and each local block comprising a plurality of CSDB-GC memory cells. A final chip measurement result shows that the 16Kb CSDB-eDRAM realizes a data retention time of 16.67 seconds, the result representing a 2.6-fold increase compared with that of the most advanced cryogenic eDRAM work at 4.2K, achieves a lower refresh power consumption of 0.11pW/Kb, further achieves a faster access time of 710ps (1.41GHz), and, compared with the most advanced work, has the lowest dynamic power consumption overhead of 49.23uW/Kb.

IPC Classes  ?

• G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating

Abstract

An automatic overclocking controller based on circuit delay measurement, comprising a CPU, a clock generator, and a circuit delay measurer controller. The innovations are that a sampling result of a circuit delay measurer is processed by using two-dimensional multi-frame synthesis technology, so as to eliminate sampling noise; and an automatic overclocking controller operating on a heterogeneous FPGA can automatically search the highest frequency at which an accelerator can securely operate.

IPC Classes  ?

• G05B 19/042 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors

Abstract

A dual-six-transistor (D6T) in-memory computing (IMC) accelerator supporting always-linear discharge and reducing digital steps is provided. In the IMC accelerator, three effective techniques are proposed: (1) A D6T bitcell can reliably run at 0.4 V and enter a standby mode at 0.26 V, to support parallel processing of dual decoupled ports. (2) An always-linear discharge and convolution mechanism (ALDCM) not only reduces a voltage of a bit line (BL), but also keeps linear calculation throughout an entire voltage range of the BL. (3) A bypass of a bias voltage time converter (BVTC) reduces digital steps, but still keeps high energy efficiency and computing density at a low voltage. A measurement result of the IMC accelerator shows that the IMC accelerator achieves an average energy efficiency of 8918 TOPS/W (8b×8b), and an average computing density of 38.6 TOPS/mm2 (8b×8b) in a 55 nm CMOS technology.

IPC Classes  ?

• G11C 11/419 - Read-write [R-W] circuits
• G11C 8/16 - Multiple access memory array, e.g. addressing one storage element via at least two independent addressing line groups
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron

Abstract

An automatic overclocking controller based on circuit delay measurement is provided, including a central processing unit (CPU), a clock generator, and a timing delay monitor (TDM) controller. Compared with the prior art, the present disclosure has following innovative points: A two-dimension-multi-frame fusion (2D-MFF) technology is used to process a sampling result, to eliminate sampling noise, and an automatic overclocking controller running on a heterogeneous field programmable gate array (FPGA) can automatically search for a highest frequency at which an accelerator can operate safely.

IPC Classes  ?

• G06F 1/26 - Power supply means, e.g. regulation thereof
• G06F 1/08 - Clock generators with changeable or programmable clock frequency
• H04B 17/364 - Delay profiles

Abstract

An efficient KNN method applied to a laser radar single-frame point cloud and a use of the efficient KNN method applied to the laser radar single-frame point cloud. The efficient KNN method applied to the laser radar single-frame point cloud is accelerated by means of an FPGA. A data structure based on point cloud projection and a distance scale is established, and the structure ensures that adjacent points in a space are organized in adjacent storages. A new data structure is efficiently constructed, and an efficient nearest point search mode is provided.

IPC Classes  ?

• G01S 7/48 - Details of systems according to groups , , of systems according to group

Abstract

An additive manufacturing method for fabricating 3D nanostructures is provided, charged species dispersed in a fluid are precisely arranged at nanoscale in each dimension with a configured electric field, so that the charged species are printed on a substrate to form an array of 3D nanostructures as desired. The additive manufacturing method of the present disclosure can be carried out at room temperature and atmospheric pressure without the aid of chemical reaction, laser sources, ion/electron beams, or photosensitive materials, and enables low-cost, ultra-fast printing speed, large-area, high-purity, multi-material, ultra-high-resolution and solves problems encountered in other nanofabrication techniques in making 3D nanostructures, such as a limited range of available printing materials, low resolution, slow printing speed, and one by one serial printing.

IPC Classes  ?

• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B33Y 80/00 - Products made by additive manufacturing
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

An energy-efficient cryogenic-in-memory-computing (CIMC) accelerator includes cryogenic 3T (C3T) macros. Each of the C3T macros comprises a C3T array containing M rows×N columns of bitcells. An input signal is converted into a timing sequence signal of a corresponding pulse width by using a digital timing sequence converter array. A C3T bitcell of a corresponding row in the C3T macro is controlled to perform charging and discharging on a read bit line (RBL) of a corresponding column. A voltage on the RBL of the corresponding column is sampled by a sense amplifier configured in each C3T macro to obtain a final result. With adaptive reference voltage configuration and storage on the chip, this design can achieve fast and low-power boolean/convolutional computing.

IPC Classes  ?

• G11C 11/405 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells with charge regeneration common to a multiplicity of memory cells, i.e. external refresh with three charge-transfer gates, e.g. MOS transistors, per cell
• G06F 17/15 - Correlation function computation
• G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating
• G11C 11/4096 - Input/output [I/O] data management or control circuits, e.g. reading or writing circuits, I/O drivers or bit-line switches
• H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits

Abstract

A technical solution of the present invention provides an ultra-low voltage SRAM unit capable of eliminating half-select disturbance in a bit-interleaved structure, characterized by comprising a read path composed of a set of inverter rings, two N-type write transistors NM1 and NM2, two P-type write transistors PM1 and PM2, and two N-type transistors NM3 and NM4. The present invention can be applied to ultra-low voltage applications having storage requirements, and in particular to applications having particular requirements for SRAM access speed and the reliability at a low voltage. Compared with other SRAM units, the present invention can achieve very high read and write operating frequencies while maintaining a low energy consumption difference.

IPC Classes  ?

• G11C 11/419 - Read-write [R-W] circuits

Abstract

Provided in the technical solution of the present invention is a global registration method based on spherical harmonic transform and iterative optimization. The method is characterized by assuming that: first, a minimum percentage of correct matching pairs in input point clouds is predefined, and is expressed as a quantitative limitation of point cloud outliers; and second, a distance threshold value used for determining the correct matching pairs is preset by a scenario, and is expressed as a limited distance of the point cloud outliers. An algorithm provided by the present invention allows point clouds to undergo coarse registration to obtain a plurality of search domains, then sorts the search domains by using evaluation standards, and excludes incorrect search domains by using a branch and bound method so as to obtain a final registration result. The algorithm disclosed by the present invention can be applied to three-dimensional reconstruction. At the same precision, the algorithm provided by the present invention is faster than all current global registration algorithms; therefore, with respect to three-dimensional reconstruction within the same time, the present invention can achieve higher precision than all of the current algorithms.

IPC Classes  ?

• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

Disclosed in the present invention is a cryogenic high-energy-efficiency computing-in-memory accelerator. The innovations of the present invention lie in: the design of a long-retention-time cryogenic 3T storage unit: provided in the present invention is the design of an eDRAM-based cryogenic 3T storage unit, which can significantly increase a retention time without any word line voltage boosting solution, and realize full-swing data transmission during a write operation process; the design of a cryogenic adaptive reconfigurable sense amplifier (ARSA): developed in the present invention is the design of a cryogenic on-chip ARSA, which can realize accurate Boolean logic calculation on a chip by means of configuring a reference voltage of the ARSA; and the design of a cryogenic optimized Flash ADC: in the present invention, the designed ARSA is used to adaptively generate reference voltages of fifteen ARSAs on a chip, and reconstruct the fifteen ARSAs into a 4-bit Flash ADC. By means of adaptively configured reference voltages and a storage mode on a chip, the design can guarantee the implementation of rapid and low-power-consumption convolution calculation.

IPC Classes  ?

• G06F 15/78 - Architectures of general purpose stored program computers comprising a single central processing unit
• G11C 7/06 - Sense amplifiersAssociated circuits
• G11C 7/18 - Bit line organisationBit line lay-out
• G11C 11/4094 - Bit-line management or control circuits
• G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating
• H03M 1/36 - Analogue value compared with reference values simultaneously only, i.e. parallel type

Abstract

A high-efficient quantization method for a deep probabilistic network achieves good result through hybrid quantization, structure reformulation, and type optimization. Firstly, for a directed acyclic graph (DAG) structure, all nodes in the DAG are clustered, and each node is quantized by a specific arithmetic type based on the clustering category, to obtain a preliminarily quantized deep probabilistic network. Secondly, the multi-in nodes in a preliminarily quantized deep probabilistic network are reformulated based on the input weights, structural reformulation converts a multi-in node into a binary tree network containing only two-input nodes, and parametrical reformulation is performed on the reformulated structure. Finally, arithmetic types of all nodes are optimized by using an arithmetic type search method based on power consumption analysis and network accuracy analysis. The method can significantly reduce computational complexity and energy consumption for computing while maintaining model accuracy of the deep probabilistic network.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 5/04 - Inference or reasoning models
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

The present disclosure provides fusion proteins combining botulinum neurotoxins (BoNTs) and cell penetration peptides (CPP) which are suitable for intramuscular administration. These fusion proteins have exceptional cellular uptake ability, potent therapeutic efficacy, and considerably increased therapeutic index when compared to the BoNT protein alone or the commercial product BOTOX® onabotulinumtoxinA. Also provided are BONT fusion proteins that are not cleaved to form two-chain polypeptides but yet retaining strong enzymatic activities. Such single-chain active BONT fusion proteins can be prepared from insect cells.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The present invention relates to an efficient quantization method for a deep probabilistic network, for use in achieving efficient quantization of a deep probabilistic network by means of hybrid quantization, structure reconstruction and type optimization. The method comprises: firstly, for the structure of a directed acyclic graph, clustering nodes of the graph and allocating arithmetic types of different precisions according to clustering category characteristics, and using the allocated arithmetic types to preliminarily quantize the nodes to obtain a preliminarily quantized deep probabilistic network; secondly, carrying out structure reconstruction of multiple input nodes on the preliminarily quantized deep probabilistic network, reconstructing, according to input weights, the multiple input nodes into a binary tree network only comprising two input nodes, and carrying out weight parameter reconstruction on the reconstructed structure; and finally, optimizing the arithmetic types of all the nodes by means of an arithmetic type search method based on power consumption analysis and network precision analysis. The method can significantly reduce the model calculation amount, lower the calculation complexity and reduce the system energy consumption while maintaining the model precision of the deep probabilistic network.

IPC Classes  ?

• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

A global registration method based on spherical harmonic transformation (SHT) and iterative optimization is provided. Two assumptions are provided: firstly, it is predefined that a minimum percentage of a correct matching pair in an input point cloud is represented as a limit on a quantity of outliers in the point cloud, and secondly, a distance threshold used to determine the correct matching pair is preset based on a scenario and represented as a limited distance of an outlier in the point cloud. In the algorithm provided, the point cloud first undergoes coarse registration to obtain a plurality of search domains, and the search domains are sorted based on an evaluation criterion. A branch and bound method is used to exclude an incorrect search domain and obtain a final registration result.

IPC Classes  ?

• G06T 7/32 - Determination of transform parameters for the alignment of images, i.e. image registration using correlation-based methods
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G06T 7/37 - Determination of transform parameters for the alignment of images, i.e. image registration using transform domain methods
• G06T 17/00 - 3D modelling for computer graphics

Abstract

An ultra-low-voltage static random access memory (SRAM) cell for eliminating half-select-disturbance under a bit interleaving structure includes a cross-coupled inverter pair, two N-type write transistors NM1 and NM2, two P-type write transistors PM1 and PM2, and two N-type transistors NM3 and NM4, where the two N-type transistors NM3 and NM4 form a readout path. The present disclosure can be applied to applications with a storage requirement at an ultra-low voltage, especially applications with certain requirements for an access speed and reliability of an SRAM at a low voltage. Compared with other different SRAM cells, the ultra-low-voltage SRAM cell can achieve higher read and write working frequencies with similar energy consumptions.

IPC Classes  ?

• G11C 11/419 - Read-write [R-W] circuits

Abstract

A novel neural modeling framework Neural Transient Field (NeTF) is provided for non-line-of-sight (NLOS) imaging. NeTF recovers the 5D transient function in both spatial location and direction, and the training data input is parametrized on the spherical wave-fronts. A Markov chain Monte Carlo (MCMC) algorithm is used to account for sparse and unbalanced sampling in NeTF.

IPC Classes  ?

• G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light
• G01S 7/4865 - Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
• G01S 17/42 - Simultaneous measurement of distance and other coordinates
• G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
• G06T 7/557 - Depth or shape recovery from multiple images from light fields, e.g. from plenoptic cameras
• G06T 7/77 - Determining position or orientation of objects or cameras using statistical methods

Abstract

A base editing system and a base editing method. The base editing system comprises: 1) a C2C9 nuclease and/or a nucleic acid encoding the C2C9 nuclease; 2) a guide RNA and/or a nucleic acid encoding the guide RNA; and 3) a deaminase and/or a nucleic acid encoding the deaminase. The base editing method comprises bringing a target gene into contact with the base editing system to achieve the editing of a single base on the target gene. The method and the system successfully achieve two different types of single base mutations at a target site, and greatly reduce the nucleic acid encoding size of the base editing system. The gene size of the protein moiety of the optimal base editing system is only 2793 bp, which is far smaller than the size of the maximum foreign gene that can be loaded by a single AAV.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/55 - Hydrolases (3)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

Provided are gene therapy technologies, including specifically designed and tested guide RNA sequences for improved base editors, useful for increasing the expression of the gamma-globin gene. The guide RNA sequences may target the BCL11A erythroid enhancer or the gamma-globin promoter, or both at the same time. The base editors can include nucleobase deaminase inhibitor that inhibits the editing activity of the base editors until they are bound to the target sites. These gene therapy technologies are useful for treating diseases including beta-thalassemia and sickle cell anemia, among others.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12N 5/078 - Cells from blood or from the immune system
• C12N 5/0789 - Stem cellsMultipotent progenitor cells
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A computer-implemented method is provided. The method includes obtaining a plurality of images representing projections of an object placed in a plurality of poses and a plurality of translations; assigning a pose embedding vector, a flow embedding vector and a contrast transfer function (CTF) embedding vector to each image; encoding, by a computer device, a machine learning model comprising a pose network, a flow network, a density network and a CTF network; training the machine learning model using the plurality of images; and reconstructing a 3D structure of the object based on the trained machine learning module.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06T 7/37 - Determination of transform parameters for the alignment of images, i.e. image registration using transform domain methods

Abstract

A deep neural network based hair rendering system is presented to model high frequency component of furry objects. Compared with existing approaches, the present method can generate photo-realistic rendering results. An acceleration method is applied in our framework, which can speed up training and rendering processes. In addition, a patch-based training scheme is introduced, which significantly increases the quality of outputs and preserves high frequency details.

IPC Classes  ?

• G06T 15/20 - Perspective computation
• G06T 7/593 - Depth or shape recovery from multiple images from stereo images
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G06T 17/00 - 3D modelling for computer graphics

Abstract

Provided is use of aloxistatin in preparing an anti-viral infection medicament, in particular, use of aloxistatin in preparing a medicament for treating a related disease caused by orthopoxvirus infection or orthopoxviruses. Aloxistatin can significantly inhibit the activity of poxvirus cysteine protease I7L. It has a potential capability to treat related diseases caused by orthopoxviruses such as monkeypox virus, smallpox virus, or vaccinia virus, and provides an effective drug use strategy for treating major infectious diseases caused by orthopoxviruses such as monkeypox virus.

IPC Classes  ?

• A61K 31/336 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
• A61P 31/20 - Antivirals for DNA viruses

Abstract

A layout method for a scalable multi-die network-on-chip FPGA architecture is provided. An application of the aforementioned layout method for the scalable multi-die network-on-chip FPGA architecture is further provided. A scalable multi-die FPGA architecture based on network-on-chip and a corresponding hierarchical recursive layout algorithm are provided, aiming to directly map a register transfer level dataflow design generated by existing high-level synthesis onto the provided interconnection architecture. The layout method can exploit the potential for hierarchical topology and make more efficient use of dedicated interconnection resources, such as cross-die nets, network-on-chips, and high-speed transceivers.

IPC Classes  ?

• G06F 30/347 - Physical level, e.g. placement or routing
• G06F 30/31 - Design entry, e.g. editors specifically adapted for circuit design

Abstract

Disclosed in the present invention is a D6T in-memory computing accelerator capable of always linearly discharging and reducing numeric steps. In the in-memory computing accelerator disclosed in the present invention, three effective technologies are provided: (1) a decoupled 6T(D6T) bit unit, which can reliably operate at 0.4 V and be standby at 0.26 V, and supports parallel processing of decoupled dual ports; and (2) an always linear discharging convolution mechanism (ALDCM), which not only can reduce the voltage of a bit line, but also can always keep linear computing within the whole voltage range of the bit line; and (3) a bypass of a bias voltage time converter (BVTC), which reduces numeric steps while still maintaining high energy efficiency and computational density at low voltages. A measurement result of the in-memory computing accelerator displays that the average energy efficiency thereof is 8918 TOPS/W(8b×8b), and the average calculation density of a 55 nm CMOS process is 38.6 TOPS/mm 2(8b×8b).

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

The present application relates to the field of conversion of hydrocarbon raw materials, in particular to a method for efficient conversion of hydrocarbon raw materials and a device thereof. The method comprises the following steps: 1) reacting a gaseous hydrocarbon raw material with a halogen substance to generate a haloalkane and a hydrogen halide; and 2) reacting the haloalkane provided in step 1) with an active metal to generate a first unsaturated hydrocarbon and a first metal halide; and 3) reacting the hydrogen halide provided in step 1) with an active metal to generate a second metal halide and hydrogen. In an electrochemical system, the present application can convert gaseous hydrocarbon raw materials into high-value products such as hydrogen, ethylene, acetylene, propylene and graphite.

IPC Classes  ?

• C25B 1/26 - ChlorineCompounds thereof
• C25C 1/00 - Electrolytic production, recovery or refining of metals by electrolysis of solutions
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C01B 7/03 - Preparation from chlorides
• C01B 3/08 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents with metals

Abstract

The present invention provides a drug combination comprising Nafamostat and K777 and a use thereof. The pharmaceutical composition comprises active ingredients, i.e., Nafamostat and K777. The pharmaceutical composition of the present invention can show a remarkable synergistic effect in related research on anti-coronavirus, and shows improvement of the effectiveness of more than 10 times in an anti-novel coronavirus test.

IPC Classes  ?

• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61P 31/12 - Antivirals
• A61P 31/14 - Antivirals for RNA viruses

Abstract

One technical solution of the present invention provides a layout method for a scalable multi-die network-on-chip FPGA architecture. The other technical solution of the present invention provides an application of the layout method for a scalable multi-die network-on-chip FPGA architecture. The present invention provides a scalable multi-die FPGA architecture based on a network-on-chip and a corresponding hierarchical recursive layout algorithm, and aims to directly map a register-transfer level dataflow design generated by means of existing high-level synthesis to the proposed interconnection architecture. According to the method provided by the present invention, the potential of a hierarchical topology can be explored, and special interconnection resources, such as a cross-grain line network, a network-on-chip and a high-speed transceiver, can be utilized more effectively.

IPC Classes  ?

• H01L 25/065 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group

Abstract

Described herein is a computer-implemented method for construction of three-dimensional images. A computing system can obtain a plurality of sparse-view sinograms of an object. The computing system can encode a machine learning model to represent a continuous density field of the object to map spatial coordinates of voxels continuous density field to an intensity values. The machine learning model can comprise an encoding module configured to map voxels of the continuous density field to a higher dimensional space through a multiresolution hash encoding technique, and a neural radiance module configured to output intensity values in accordance with spatial coordinates of the voxels of the continuous density field. The computing system can train the machine learning model using the plurality of sparse-view sinograms. The computing system can determine the spatial coordinates of the voxels of the three-dimensional image of the object to be constructed. The computing system can input the spatial coordinates of the voxels of the three dimensional image into the trained machine learning model. The computing system can construct the three-dimensional image based on a dense-view sinogram generated by the trained machine learning model.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor. An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor.

IPC Classes  ?

• C07D 471/14 - Ortho-condensed systems
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 25/24 - Antidepressants
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

An energy-efficient point cloud feature extraction method based on a field-programmable gate array (FPGA) is mapped onto the FPGA for running. The energy-efficient point cloud feature extraction method based on the FPGA is applied to point cloud feature extraction in unmanned driving; or an intelligent robot. Compared with an existing technical solution, the energy-efficient point cloud feature extraction method based on the FPGA has following innovative points: a low-complexity projection method for organizing unordered and sparse point clouds, a high-parallel method for extracting a coarse-grained feature point, and a high-parallel method for selecting a fine-grained feature point.

IPC Classes  ?

• G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light
• G06F 18/2135 - Feature extraction, e.g. by transforming the feature spaceSummarisationMappings, e.g. subspace methods based on approximation criteria, e.g. principal component analysis

Abstract

One technical solution of the present invention provides a high-energy-efficiency FPGA-based point cloud feature extraction method, which is mapped to an FPGA for running. Another technical solution of the present invention provides a use of the high-energy-efficiency FPGA-based point cloud feature extraction method, wherein the method is used for point cloud feature extraction of unmanned driving or robots. Compared with the prior art, the innovation of the present invention is: providing a low-complexity projection method for organizing disordered and sparse point clouds, a high parallelism method for extracting coarse-grained feature points, and a high parallelism method for selecting fine-grained feature points.

IPC Classes  ?

• G01S 7/48 - Details of systems according to groups , , of systems according to group
• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06T 15/10 - Geometric effects
• G05B 19/05 - Programmable logic controllers, e.g. simulating logic interconnections of signals according to ladder diagrams or function charts

Abstract

Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.

IPC Classes  ?

• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

A max-flow/min-cut solution algorithm for early terminating a push-relabel algorithm is provided. The max-flow/min-cut solution algorithm is used for an application that does not require an exact maximum flow, and includes: defining an early termination condition of the push-relabel algorithm by a separation condition and a stable condition; determining that the separation condition is satisfied if there is no source node s, s∈S, in the set T at any time in an operation process of the push-relabel algorithm; determining that the stable condition is satisfied if there is no active node in the set T; and terminating the push-relabel algorithm if both the separation condition and the stability condition are satisfied. The early termination technique is proposed to greatly reduce redundant computations and ensure that the algorithm terminates correctly in all cases.

IPC Classes  ?

• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/96 - Management of image or video recognition tasks

Abstract

An image rendering system comprising a preprocessing unit coupled to a feature extract unit and a color rendering unit over a data bus. The preprocessing unit generates vector representations of spatial coordinates of sample points along camera rays corresponding to pixels of an image to be rendered. The feature extract unit generates a feature map of the image based on the vector representations, color and intensity values of the sample point through a first machine learning model. The color rendering unit renders the image based on the feature map through a second machine learning model. The first machine learning model is different from the second machine learning model.

IPC Classes  ?

• G06T 15/00 - 3D [Three Dimensional] image rendering
• G06T 7/90 - Determination of colour characteristics

Abstract

The present invention relates to the technical field of biology, and particularly, to an optimized guide RNA, a CRISPR/AcC2C9 gene editing system, and a gene editing method. The guide RNA comprises an RNA framework and a gene targeting section. The RNA framework comprises tracrRNA and a tracr counterpart. A nucleotide sequence of the tracrRNA is a sequence obtained by addition, reduction, or replacement of part of nucleotides in a nucleotide sequence set forth in SEQ ID NO. 117. A nucleotide sequence of the tracr counterpart is a sequence obtained by addition, reduction, or replacement of part of nucleotides in a nucleotide sequence set forth in SEQ ID NO. 127. By utilizing the optimized guide RNA and the CRISPR/AcC2C9 gene editing system, efficient and accurate gene editing in a cell can be realized. Compared with a previously unoptimized CRISPR/AcC2C9 gene editing system, the editing efficiency and applicability of the editing system can be greatly improved by utilizing the optimized guide RNA and the CRISPR/AcC2C9 gene editing system.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/55 - Hydrolases (3)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The present application relates to a novel benzoazepine compound, comprising a pharmaceutically acceptable salt thereof. The present application also provides a pharmaceutical composition comprising the compound and a pharmaceutically acceptable salt thereof. The present application relates to use of the compound and the composition in the prevention or treatment of diseases related to arginine vasopressin V1a receptor, arginine vasopressin V1b receptor, arginine vasopressin V2 receptor, sympathetic nervous system or renin-angiotensin-aldosterone system. The present application also provides a method for preventing and/or treating arginine vasopressin-related diseases.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C07D 223/16 - BenzazepinesHydrogenated benzazepines

Abstract

The present invention relates to the technical field of medicine. Provided are a biological tissue recognition model construction method and apparatus, and an electronic device. The method comprises: decomposing a biological tissue training sample to obtain features of biological tissue training sample images; constructing mapping relationships between the features of the biological tissue training sample images and training sample tissue types; training a biological tissue recognition model by using several mapping relationships, so as to obtain initial parameters of the biological tissue recognition model; and inputting biological tissue supporting sample information into the biological tissue recognition model, which is configured with the initial parameters, to perform parameter fine tuning, so as to obtain an optimized biological tissue recognition model. In the present application, an image of biological tissue to be recognized is acquired by means of a miniature ultrahigh-frequency ultrasonic probe, and then the image of said biological tissue is input into a biological tissue recognition model, so as to recognize said biological tissue under a spinal endoscope, and to improve the recognition efficiency of the tissue under the spinal endoscope.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting

Abstract

The present invention provides a spatial electric field control device applied to 3D printing. By changing the potentials and relative movement positions of a top electrode plate, one or more intermediate electrode plates provided with hole positions, and a bottom electrode plate which are placed in sequence, and by changing the size, number, shape and distribution of the hole positions on the electrode plates, a focusing electric field required for printing is constructed, wherein the electric field has functions of convergence, dispersion, screening and separation on charged substances in the electric field. According to the present invention, the intensity of the spatial electric field and the shape of power lines can be adjusted by means of the potential configuration, position arrangement, and hole position distribution of the electrode plates, so that the characteristic size and printing sites of 3D printing can be adjusted and controlled, thereby achieving the advantages such as high flexibility, simple operation, and high controllability. Moreover, the present invention can be applied across scales, and by depending on scales of corresponding devices, the present invention can print structures from centimeter to nanometer. The present invention can also be applied to the fields of micro-nano processing, separation engineering, signal processing, etc., and realizes functions of beam convergence, signal change, dispersion, or screening, etc.

IPC Classes  ?

• B29C 64/10 - Processes of additive manufacturing

Abstract

Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases
• C12N 9/50 - Proteinases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The present disclosure provides chimeric polypeptides that include one or more zinc finger motif fused to a therapeutic peptide such as botulinum neurotoxins (BoNTs). The zinc finger motif may be located at the C-terminal side of the BoNT and the chimeric polypeptide can optionally include two or more such zinc finger motifs. It is shown that the disclosed chimeric polypeptides can be efficiently delivered to a subject transdermally.

IPC Classes  ?

• C07K 14/33 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Clostridium (G)
• C07K 19/00 - Hybrid peptides

Abstract

A computer-implemented method includes encoding a radiance field of an object onto a machine learning model; conducting, based on a set of training images of the object, a training process on the machine learning model to obtain a trained machine learning model, wherein the training process includes a first training process using a plurality of first test sample points followed by a second training process using a plurality of second test sample points located within a threshold distance from a surface region of the object; obtaining target view parameters indicating a view direction of the object; obtaining a plurality of rays associated with a target image of the object; obtaining render sample points on the plurality of rays associated with the target image; and rendering, by inputting the render sample points to the trained machine learning model, colors associated with the pixels of the target image.

IPC Classes  ?

• G06T 15/55 - Radiosity
• G06T 15/20 - Perspective computation
• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation

Abstract

The present invention provides the following compound (I) or a pharmaceutically acceptable salt, an ester, an optical isomer, a tautomer, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotope-labeled compound, a metabolite, a chelate, a complex, a clathrate, or a prodrug thereof, and a pharmaceutical composition comprising the compound of the present invention. Also provided are use of the compound of the present invention as an apoptosis signal-regulating kinase 1 (ASK1) inhibitor, use of the compound in the preparation of a drug for related apoptosis signal-regulating kinase 1 (ASK1) diseases, and a corresponding pharmaceutical composition.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

Provided are compositions and methods for enhanced prime editing, which include a pegRNA that encodes a target mutation in a target protein, along with one or more nearby silent or conservative mutations. These silent mutations can increase the editing efficiency, without causing a change to the target protein sequence. Also provided are compositions and methods of using the improved prime editing for preventing or treating infections by SARS-CoV or SARS-CoV-2.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

Provided are a nucleic acid construct based on a Cre-LoxP recombination system and a CRISPR gene editing system and use thereof. The Cre-LoxP recombination system comprises a Cre enzyme and a LoxP nucleic acid combination. The LoxP nucleic acid combination comprises TATA-Lox71 and TATA-LoxTC9 sequences, which can only be recombined once under the catalysis of the Cre enzyme. The nucleic acid construct carries an inert "filling sequence" with a certain length. The nucleic acid construct can express a plurality of sgRNAs in a low bias manner in vivo, but a same cell can only express one sgRNA, thereby efficiently generating a genetic chimera, and use of the latter comprises accurate and sensitive in-situ CRISPR gene screening and rapid and low-cost preparation of a single-gene knockout strain.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A01K 67/027 - New or modified breeds of vertebrates

Abstract

Provided is use of an mTOR inhibitor in enhancing the efficacy of a targeted protein degradation drug. The mTOR inhibitor can significantly enhance the degradation of a substrate protein by small-molecule targeted protein degradation drugs such as molecular glue and PROTAC, so as to achieve the purpose of treating a disease. It is particularly suitable for myeloma patients who have a reduced therapeutic effect and recurrence due to resistance to immunomodulatory drugs IMiDs in drugs such as molecular glue. Provided is a pharmaceutical composition comprising molecular glue and PROTAC protein degraders and an mTOR inhibitor. The capability of promoting degradation of the substrate protein by the targeted protein degradation drug is achieved, so that the effectiveness of the drug for treating diseases is improved.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

Systems, methods, and non-transitory computer-readable media are configured to obtain a set of content items to train a neural radiance field-based (NeRF-based) machine learning model for object recognition. Depth maps of objects depicted in the set of content items can be determined. A first set of training data comprising reconstructed content items depicting only the objects can be generated based on the depth maps. A second set of training data comprising one or more optimal training paths associated with the set of content items can be generated based on the depth maps. The one or more optimal training paths are generated based at least in part on a dissimilarity matrix associated with the set of content items. The NeRF-based machine learning model can be trained based on the first set of training data and the second set of training data.

IPC Classes  ?

• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06T 7/50 - Depth or shape recovery
• G06T 7/80 - Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration
• G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
• G06V 20/64 - Three-dimensional objects

Abstract

Disclosed is a CRISPR-based detection kit and use thereof. The detection kit of the present invention comprises a gene editing system. The gene editing system comprises a nuclease and a guide RNA. The sequence of the guide RNA is selected from one or more of nucleotide sequences set forth in SEQ ID NOs: 1-4. The kit of the present invention can reduce the detection limit while improving the detection efficiency within a shortened reaction time and reduced reaction temperature. The operation does not include nucleic acid extraction, eliminating the need for uncovering, thus being simple, convenient, and rapid.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12R 1/93 - Animal viruses

Abstract

Provided are an optimized CRISPR/SpCas12f1 system, an engineered guide RNA and use thereof. The CRISPR/SpCas12f1 genome editing system comprises: an expression construct comprising an SpCas12f1 nuclease; and an expression construct comprising an expressed DNA sequence for a guide RNA corresponding to the SpCas12f1 nuclease and a targeting sequence of a target sequence. Also provided is a method for optimizing a guide RNA corresponding to an SpCas12f1 nuclease, comprising: modifying tracrRNA and crRNA individually or in combination. By using the gene editing system of the present invention, a target gene in a cell can be accurately edited; by using the optimized guide RNA of the present invention, the editing efficiency and applicability of the editing system can be greatly improved.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases

Abstract

Provided are a novel genome-editing system based on a very small engineering-optimized CRISPR/AsCas12f1, and a method and use thereof. The system comprises: a novel engineering-optimized guide RNA variant, and an expression construct comprising the variant sequence; and a plurality of engineering-optimized AsCas12f1 nuclease variants comprising one or more point mutations at amino acid positions 80, 104 and 364, and expression constructs comprising the variant sequences. Also provided is a gene-editing system based on an engineering-optimized CRISPR/AsCas12f1, characterized by any combination of a guide RNA wild-type or a guide RNA variant with an AsCas12f1 nuclease wild-type or a variant thereof.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/52 - Genes encoding for enzymes or proenzymes

Abstract

Disclosed are a compound and an application thereof in the preparation of a medicine for treating enterovirus-related diseases. The compound is the compound represented below by formula I, and can significantly inhibit the 3C protease activity of various enteroviruses. At present, no specific medicine aimed at human enteroviruses has been approved to come to market, and the use of the solution of the present invention can compensate for the insufficiencies of the prior art.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 207/26 - 2-Pyrrolidones
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/404 - Indoles, e.g. pindolol
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A method for catalytic synthesis of ammonia under normal pressures, including: performing a reaction of hydrogen and nitrogen to synthesize ammonia under normal pressures by taking a liquid alloy as a catalyst in a reactor, where the reactor contains a molten salt, the density of the molten salt is smaller than that of the liquid alloy, and the molten salt is used for providing a reaction interface and isolating the liquid alloy from being introduced impurities. The first metal reacts with the nitrogen to produce the metal nitride, and the molten salt provides a new reaction interface for the metal nitride to react with the hydrogen to synthesize ammonia, so that ammonia is produced continuously. In addition, the molten salt prevents the liquid alloy from contacting with the oxygen and the water vapor, which prevents the liquid alloy from being oxidized, thus prolonging its service life.

IPC Classes  ?

• B01J 23/14 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of germanium, tin or lead
• B01J 23/04 - Alkali metals
• B01J 35/61 - Surface area
• C01C 1/04 - Preparation of ammonia by synthesis

Abstract

Disclosed in the present invention are a triazolamide compound, a preparation method therefor, and a use thereof. Specifically, disclosed are a triazolamide compound as shown in formula I or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating and/or preventing HDAC-related diseases. The diseases may be cancers.

IPC Classes  ?

• C07D 249/06 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are a sensor (1), an X-ray detector and the use thereof. The sensor (1) comprises sensing units (11) and shielding layers (12) successively arranged at intervals in a Y direction. Each sensing unit (11) comprises a first electrode layer (111), a sensor layer (112) and a second electrode layer (113) successively arranged in the Y direction. Each first electrode layer (111) comprises a plurality of collector electrodes (1111) successively arranged at intervals in an X direction and used for collecting signals. At least one drift electrode (1112) is arranged at intervals between each two adjacent collector electrodes (1111), so as to reduce the area of the collector electrodes (1111), thereby effectively reducing an input capacitance, reducing the width of a signal waveform, improving signal uniformity, and improving the performance of a detector. Each sensor layer (112) comprises one of gallium arsenide, chromium compensated gallium arsenide, chromium doped gallium arsenide or aluminum doped gallium arsenide. Each second electrode layer (113) comprises at least one cathode (1131). Each shielding layer (12) is located between two adjacent sensing units (11), and comprises at least one of physical shielding and electrical shielding to prevent signal crosstalk.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]

Abstract

Provided are an anti-SARS-Cov-2 nanobody and use thereof. The nanobody comprises CDR1, CDR2 and CDR3; the amino acid sequence of CDR1 is set forth in SEQ ID NO: 1, the amino acid sequence of CDR2 is set forth in SEQ ID NO: 2, and the amino acid sequence of CDR3 is set forth in SEQ ID NO: 3. Provided is a fusion protein, which is formed by the conjugation of the nanobody and an Fc, or by the conjugation of two or more nanobodies. The use refers to use of the nanobody or the fusion protein in the preparation of a drug for treating SARS-Cov-2. The nanobody has the potential to neutralize the Omicron strain, and has the advantages of small molecular weight, high binding activity, stable physical and chemical properties, ease of mass production, transport, storage, and the like. The nanobody can bind to RBDO and almost completely inhibits the binding of RBDO to ACE2, providing the foundations for the design and assembly of bispecific or even multispecific antibodies and CAR molecules.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61P 31/14 - Antivirals for RNA viruses
• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral

Abstract

A fusion protein which may comprise a first nCas9 fragment, a chimeric insertion fragment, a second nCas9 fragment and two UGI fragments from N-terminus to C-terminus, wherein the chimeric insertion fragment is selected from APOBEC1 fragment or APOBEC3A fragment for cytosine deamination at the target site. The fusion protein may comprise a first nCas9 fragment, a chimeric insertion fragment and a second nCas9 fragment from N-terminus to C-terminus, wherein the chimeric insertion fragment is TadA-TadA* for cytosine deamination at the target site. The present disclosure provides a novel base editing tool that is compatible with insertion of various deaminases on the chimeric sites of nCas9. Compared with nCas9 terminal fusion base editor, the base editing tool of the present invention significantly reduce off-targeting on both DNA and RNA, while maintaining specific targeted base editing efficiency, with higher specificity and favorable industrialization prospects.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• C07K 14/775 - Apolipopeptides
• C12N 9/22 - Ribonucleases

Abstract

Disclosed is compound YM155, tanshinone I or cryptotanshinone, or a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof, or a crystal form thereof; for treating and/or preventing diseases caused by coronavirus.

IPC Classes  ?

• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings

Abstract

The present disclosure provides compounds of formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and applications thereof, and pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and applications of the pharmaceutical compositions. The compounds can effectively prevent and/or treat diseases or disorders associated with TNF-α. The present disclosure provides compounds of formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and applications thereof, and pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and applications of the pharmaceutical compositions. The compounds can effectively prevent and/or treat diseases or disorders associated with TNF-α.

IPC Classes  ?

• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

An application of disulfiram in coronavirus resistance. An application of disulfiram in the preparation of drugs for treating and/or preventing diseases caused by coronaviruses. By means of in vitro enzyme activity experiments, it is found that disulfiram can well inhibit the activity of the main protease in coronaviruses, filling in the lack in the prior art to treat diseases caused by coronaviruses.

IPC Classes  ?

• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A preparation method for mutant cells with deletion of target genes, at least comprising the following steps: (1) transfecting a sgRNA group into same host cells, where the sgRNA group includes two sgRNAs that target different sites of a same target gene, and the number of the sgRNA group may be one or more than one. When the number of the sgRNA group is more than one, each different sgRNA group targets one different target gene. (2) Enriching the host cells expressing one or more sgRNA groups. (3) Culturing the host cells obtained from step (2) to produce mutant cells with deletion of target genes.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells