The present disclosure relates to a bioreactor assembly having a housing defining an interior chamber; a lid assembly removably coupled to the housing and enclosing the interior chamber; and a gimbal assembly disposable within the interior chamber. The gimbal assembly includes a cradle configured to hold an organ or organ scaffold and an arm assembly configured to move the cradle between a plurality of positions. The bioreactor assembly also includes an ultrasound imaging unit positioned to capture volumetric and/or spatial data of the organ or organ scaffold.
The present disclosure relates to a bioreactor assembly having a housing defining an interior chamber; a lid assembly removably coupled to the housing and enclosing the interior chamber; and a gimbal assembly disposable within the interior chamber. The gimbal assembly includes a cradle configured to hold an organ or organ scaffold and an arm assembly configured to move the cradle between a plurality of positions. The bioreactor assembly also includes an ultrasound imaging unit positioned to capture volumetric and/or spatial data of the organ or organ scaffold.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Three-dimensional (3-D) printers Laboratory equipment and instruments, namely, computer robotics-supported workstations, comprising three-dimensional printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras, downloadable software for visualization of workstation operations and downloadable software for environmental control of workstation, and automated conveyance and controlled storage system for production of biological specimens Training in the fields of three-dimensional printing and computer robotics-supported workstations for production of biological specimens Scientific research consulting in the fields of three-dimensional printing and computer robotics-supported workstations for production of biological specimens
5.
END EFFECTOR ASSEMBLIES, SYSTEMS, AND METHODS OF USE
End effector assemblies according to the present disclosure include a tool body mounted to a robotic arm and an impedance-measuring tip coupled to the tool body. The impedance-measuring tip defines a first volume to receive a fluid and a first dispensing outlet for dispensing the fluid. The impedance-measuring tip includes an impedance-measuring sensor configured to output a signal indicative of a change in impedance. A tip extension is fluidically coupled to the impedance-measuring tip that defines a second volume for receiving the fluid. A camera is coupled to the tool body and configured to capture image data of the second volume that captures at least a visual representation of a number of cells or other objects in the second volume. A pump is coupled to the impedance-measuring tip to dispense the fluid from the first volume into the second volume and from the second volume into a receptacle.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
End effector assemblies according to the present disclosure include a tool body mounted to a robotic arm and an impedance-measuring tip coupled to the tool body. The impedance-measuring tip defines a first volume to receive a fluid and a first dispensing outlet for dispensing the fluid. The impedance-measuring tip includes an impedance-measuring sensor configured to output a signal indicative of a change in impedance. A tip extension is fluidically coupled to the impedance-measuring tip that defines a second volume for receiving the fluid. A camera is coupled to the tool body and configured to capture image data of the second volume that captures at least a visual representation of a number of cells or other objects in the second volume. A pump is coupled to the impedance-measuring tip to dispense the fluid from the first volume into the second volume and from the second volume into a receptacle.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Biological tissue cultures for medical use containing viable cells, cellular components, and/or growth factors with bone matrix used for the repair and regeneration of bone; engineered biological tissues, namely, human allograft bone tissue; bone growth media consisting of biological materials for medical purposes; biological implants, namely, human allograft bone tissue
8.
MODELS AND METHODS TO ESTABLISH PERFUSABLE, COMPARTMENTALIZED, LYMPHOID TISSUE MODELS IN THREE-DIMENSIONAL IN VITRO CULTURE
A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.
A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.
A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes positioning a second material distribution barrel within a second barrel orifice, where a second barrel tip is disposed at a first end of the second material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
A modular platform for a bioassembly system includes a platform frame and one or more removable stage inserts. The frame has a receiving portion and one or more frame electrical connections. Each removable stage insert is respectively configured to be received in the receiving portion of the platform frame in an inserted position. Each removable stage insert includes one or more insert electrical connections communicatively coupled to the one or more frame electrical connections when in the inserted position. The bioassembly system also includes a controller and a communicatively coupled memory including machine-readable instructions.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
12.
BARREL CLAMPING MECHANISMS, SYSTEMS, AND METHODS FOR 3D PRINTING
A 3D printing assembly, system, and method for 3D printing a biomaterial may include a robotic arm end effector and a barrel clamp assembly. The robotic arm end effector is configured to move along one or more axes of movement for 3D printing. The barrel clamp assembly is distally coupled to the robotic arm end effector and includes a barrel clamp arm and a barrel clamp. The barrel clamp arm includes a top end coupled to the robotic arm end effector and a bottom end opposite to the top end. The bottom end is angled forward with respect to the top end. The barrel clamp is coupled to the bottom end of the barrel clamp arm and is configured to receive and clamp against a distal end of a printing syringe barrel for 3D printing.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
13.
Barrel Clamping Mechanisms, Systems, and Methods for 3D Printing
A 3D printing assembly, system, and method for 3D printing a biomaterial may include a robotic arm end effector and a barrel clamp assembly. The robotic arm end effector is configured to move along one or more axes of movement for 3D printing. The barrel clamp assembly is distally coupled to the robotic arm end effector and includes a barrel clamp arm and a barrel clamp. The barrel clamp arm includes a top end coupled to the robotic arm end effector and a bottom end opposite to the top end. The bottom end is angled forward with respect to the top end. The barrel clamp is coupled to the bottom end of the barrel clamp arm and is configured to receive and clamp against a distal end of a printing syringe barrel for 3D printing.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
A tiltable stage assembly includes a base and a tiltable stage operably coupled to the base and pivotable relative to the base. The tiltable stage is moveable between an initial position and a tilted position, wherein the tiltable stage is parallel with the base in the initial position and is oriented at an angle to the base when in the tilted position. The tiltable stage is biased to the initial position.
A tiltable stage assembly includes a base and a tiltable stage operably coupled to the base and pivotable relative to the base. The tiltable stage is moveable between an initial position and a tilted position, wherein the tiltable stage is parallel with the base in the initial position and is oriented at an angle to the base when in the tilted position. The tiltable stage is biased to the initial position.
A biofabrication system includes a workstation and an articulating arm disposed within a work area of a biosafety cabinet. The workstation includes a stage for biofabrication. The biosafety cabinet includes an integration port that provides access to the work area through a wall of the biosafety cabinet. The articulating arm may be positioned to reach the workstation and the integration port.
B08B 15/02 - Preventing escape of dirt or fumes from the area where they are produced; Collecting or removing dirt or fumes from that area using chambers or hoods covering the area
A biofabrication system includes a workstation and an articulating arm disposed within a work area of a biosafety cabinet. The workstation includes a stage for biofabrication. The biosafety cabinet includes an integration port that provides access to the work area through a wall of the biosafety cabinet. The articulating arm may be positioned to reach the workstation and the integration port.
B25J 21/00 - Chambers provided with manipulation devices
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B08B 15/02 - Preventing escape of dirt or fumes from the area where they are produced; Collecting or removing dirt or fumes from that area using chambers or hoods covering the area
18.
MODELS AND METHODS TO ESTABLISH PERFUSED VASCULARIZED TISSUES IN THREE-DIMENSIONAL IN VITRO CULTURE
Provided herein are 3D tumor angiogenesis models and their methods of preparation and use. In some aspects, the need for identifying whether a potential drug target influences angiogenesis, identifying compounds that modulate angiogenesis, and identifying new drug targets for modulating angiogenesis.
Provided herein are 3D tumor angiogenesis models and their methods of preparation and use. In some aspects, the need for identifying whether a potential drug target influences angiogenesis, identifying compounds that modulate angiogenesis, and identifying new drug targets for modulating angiogenesis.
Industrial robots, conveyors being machines, and machines for sorting, namely, grippers, graspers and end effectors for use with 3D printers for printing biologic tissue and biologic materials
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing on-line forums for transmission of messages among computer users; electronic bulletin board services On-line journals, namely, blogs featuring 3D printing technology, bio printing, biotechnology, and bioengineering Computer technology support services, namely, help desk services
22.
VASCULARIZED ORGANOID MODEL INCORPORATING ISOLATED HUMAN MICROVESSEL FRAGMENTS
A method for producing a functional, vascularized organoid or spheroid is provided, the method including: (a) mixing a suspension of stromal cells with microvessel (MV) fragments isolated from adipose tissue to provide an MV/stromal cell suspension; and (b) culturing the MV/stromal cell suspension in an angiogenic medium to provide the functional, vascularized organoid or spheroid. Also provided is a method for producing a functional, vascularized adipocyte organoid or spheroid and a method of screening compounds for pharmacological or toxicological activity, using the vascularized organoids and/or spheroids provided herein.
A method for producing a functional, vascularized organoid or spheroid is provided, the method including: (a) mixing a suspension of stromal cells with microvessel (MV) fragments isolated from adipose tissue to provide an MV/stromal cell suspension; and (b) culturing the MV/stromal cell suspension in an angiogenic medium to provide the functional, vascularized organoid or spheroid. Also provided is a method for producing a functional, vascularized adipocyte organoid or spheroid and a method of screening compounds for pharmacological or toxicological activity, using the vascularized organoids and/or spheroids provided herein.
Industrial robots, conveyors being machines, and machines for sorting, namely, grippers, graspers and end effectors for use with 3D printers for printing biologic tissue and biologic materials
Industrial robots, conveyors being machines, and machines for sorting, namely, grippers, graspers and end effectors for use with 3D printers for printing biologic tissue and biologic materials
26.
System and workstation for the design, fabrication and assembly of bio-material constructs
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non-biological constructs. The robotic bioassembly workstation includes a six-axis robot providing the capability for oblique-angle printing, printing by non-sequential planar layering, and printing on print substrates having variable surface topographies, enabling fabrication of more complex bio-constructs including tissues, organs and vascular trees.
Methods and systems for 3D printing use a 3D printing device defined by a polar coordinate frame including an r-axis, a z-axis, and a rotational theta axis. The device includes a base, a rotatably attached printing stage is rotatably attached, a z-axis aligned pair of towers, an r-axis aligned rail slidably coupled to the towers, a print head slidably disposed on the rail, a printing tool coupling component (“master”) joined to the print head, and a rotatable tool carousel with bays housing printing tools, each including a printing tool body (“slave”). The slave may be coupled with and locked to or unlocked from the master to form a coupled tool assembly through a mechanical actuation assembly. With the coupled tool assembly, a printing tool is removable from a respective bay when the coupled tool assembly moves along the r-axis in a direction opposite from the rotatable tool carousel.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 40/00 - Auxiliary operations or equipment, e.g. for material handling
A modular light for removably attaching to a bio-printer robot end effector (1205), where the light includes: an annular modular light ring housing (118) with an annular opening (108) for receiving the end effector (1205) of the bioprinting robot (1200); the housing (118) substantially surrounding a dispensing tip (315) of the end effector (1205); a power supply interface to receive electrical power from the end effector (1205); a plurality of LEDs (102) positioned annularly around the end effector (1205) within the annular modular light ring housing (118), where the plurality of LEDs (102) are spaced in at least two annular rows (104), where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing (118) with respect to a light output plane of the annular modular light ring housing (118); the LEDs (102) are in electrical communication with the power supply interface; and a controller (1305) communicatively coupled with the LEDs (102) and the power supply interface.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
B22F 10/00 - Additive manufacturing of workpieces or articles from metallic powder
B22F 12/00 - Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
31.
Modular light source for curing of 3D printed biological and engineered materials
A modular light for removably attaching to a bio-printer robot end effector, where the light includes: an annular modular light ring housing with an annular opening for receiving the end effector of the bioprinting robot; the housing substantially surrounding a dispensing tip of the end effector; a power supply interface to receive electrical power from the end effector; a plurality of LEDs positioned annularly around the end effector within the annular modular light ring housing, where the plurality of LEDs are spaced in at least two annular rows, where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing with respect to a light output plane of the annular modular light ring housing; the LEDs are in electrical communication with the power supply interface; and a controller communicatively coupled with the LEDs and the power supply interface.
B29C 64/282 - Arrangements for irradiation using multiple radiation means, e.g. micromirrors or multiple light-emitting diodes [LED] of the same type, e.g. using different energy levels
B29C 64/379 - Handling of additively manufactured objects, e.g. using robots
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 80/00 - Products made by additive manufacturing
F21Y 105/18 - Planar light sources comprising a two-dimensional array of point-like light-generating elements characterised by the overall shape of the two-dimensional array polygonal other than square or rectangular, e.g. for spotlights or for generating an axially symmetrical light beam
High-throughput column arrays of vascularized living parenchyma/tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Vascularized liver tissue modules consisting primarily of biological tissue in the nature of human liver tissue and cells for laboratory and medical research for diagnosis and treatment of liver disease and liver disorders Vascularized liver tissue modules consisting primarily of vascular grafts for laboratory and medical research for diagnosis and treatment of liver disease and liver disorders
Provided herein is a living bone graft including a biofabricated graft core including demineralized bone matrix and a carrier and a pre-vascularized shell at least partially enrobing the graft core, the pre-vascularized shell including isolated, intact adipose-derived microvessel fragments, mesenchymal stem cells, and collagen. The disclosed bone grafts include stromal cells that differentiate and microvessels that inosculate to provide a functional microvasculature, thereby approximating native bone repair as the graft matures in the patient. Also provided herein are methods of fabricating a bespoke, living, vascularized bone graft and methods of treating a segmental bone defect in a patient.
Provided herein is a living bone graft including a biofabricated graft core including demineralized bone matrix and a carrier and a pre-vascularized shell at least partially enrobing the graft core, the pre-vascularized shell including isolated, intact adipose-derived microvessel fragments, mesenchymal stem cells, and collagen. The disclosed bone grafts include stromal cells that differentiate and microvessels that inosculate to provide a functional microvasculature, thereby approximating native bone repair as the graft matures in the patient. Also provided herein are methods of fabricating a bespoke, living, vascularized bone graft and methods of treating a segmental bone defect in a patient.
Provided herein is a living bone graft including a biofabricated graft core including demineralized bone matrix and a carrier and a pre-vascularized shell at least partially enrobing the graft core, the pre-vascularized shell including isolated, intact adipose-derived microvessel fragments, mesenchymal stem cells, and collagen. The disclosed bone grafts include stromal cells that differentiate and microvessels that inosculate to provide a functional microvasculature, thereby approximating native bone repair as the graft matures in the patient. Also provided herein are methods of fabricating a bespoke, living, vascularized bone graft and methods of treating a segmental bone defect in a patient.
An end effector includes a continuous volume that holds a constituent and includes a nozzle, a suspension frame disposed within the continuous volume, an actuator, and an agitation needle that protrudes from the continuous volume through the nozzle. The actuator is suspended by the suspension frame within the continuous volume such that the constituent within the continuous volume is in direct contact with one or more of the actuator and the agitation needle. The actuator is configured to actuate such that, upon actuation, the constituent transforms from a static state to a pseudo-fluid like state for application with the end effector.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
An end effector includes a continuous volume that holds a constituent and includes a nozzle, a suspension frame disposed within the continuous volume, an actuator, and an agitation needle that protrudes from the continuous volume through the nozzle. The actuator is suspended by the suspension frame within the continuous volume such that the constituent within the continuous volume is in direct contact with one or more of the actuator and the agitation needle. The actuator is configured to actuate such that, upon actuation, the constituent transforms from a static state to a pseudo-fluid like state for application with the end effector.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
A 3D printer includes a multi-axis robot arm comprising a deposition end effector, a rotating adjustable print stage comprising a rotary unit and a mandrel, the rotating adjustable print stage configured to rotate the mandrel around a rotation axis, and a control unit. The control unit may be configured to move the robotic arm in a radial dimension and a longitudinal dimension with respect to the mandrel to position the deposition end effector with respect to the mandrel, rotate the mandrel with the rotary unit, and cause the deposition end effector to deposit constituent on the mandrel to form a 3D-printed construct.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
A 3D printer includes a multi-axis robot arm comprising a deposition end effector, a rotating adjustable print stage comprising a rotary unit and a mandrel, the rotating adjustable print stage configured to rotate the mandrel around a rotation axis, and a control unit. The control unit may be configured to move the robotic arm in a radial dimension and a longitudinal dimension with respect to the mandrel to position the deposition end effector with respect to the mandrel, rotate the mandrel with the rotary unit, and cause the deposition end effector to deposit constituent on the mandrel to form a 3D-printed construct.
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
A 3D printer includes a multi-axis robot arm comprising a deposition end effector, a rotating adjustable print stage comprising a rotary unit and a mandrel, the rotating adjustable print stage configured to rotate the mandrel around a rotation axis, and a control unit. The control unit may be configured to move the robotic arm in a radial dimension and a longitudinal dimension with respect to the mandrel to position the deposition end effector with respect to the mandrel, rotate the mandrel with the rotary unit, and cause the deposition end effector to deposit constituent on the mandrel to form a 3D-printed construct.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
Systems and methods for a robotic fabrication and assembly platform providing a plurality of printable materials for fabrication of a three-dimensional object are provided. A method includes activating a pneumatic actuator to extend a quick-change turret from a pneumatic seal. The method may insert a plurality of barrels into the quick-change turret. The method may also align one of the plurality of barrels with a pneumatic seal in the quick-change turret. The method may also disengage the pneumatic actuator to seat the aligned barrel onto the pneumatic seal and print a three-dimensional object. The method may further halt the printing of the three-dimensional object prior to completion and engage the pneumatic actuator to extend the quick-change turret from the pneumatic seal.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/232 - Driving means for motion along the axis orthogonal to the plane of a layer
A system for automated biological structure identification using machine learning includes a host device configured to receive an instruction selecting a biological structure to identify, access computer readable media storing multiple machine learning models configured to identify biological structures, select a model among the machine learning models based on the received instruction, receive image data, identify the biological structure, out-of-focus, in the image data using the selected model, send adjustment instructions to an imaging device to adjust focus of the imaging device, receive adjusted image data corresponding to the adjustment instructions, and identify the biological structure, in-focus, in the adjusted image data using the selected model. The host device generates annotations corresponding to the identified biological structure and displays the image data and annotations.
A system for automated biological structure identification using machine learning includes a host device configured to receive an instruction selecting a biological structure to identify, access computer readable media storing multiple machine learning models configured to identify biological structures, select a model among the machine learning models based on the received instruction, receive image data, identify the biological structure, out-of-focus, in the image data using the selected model, send adjustment instructions to an imaging device to adjust focus of the imaging device, receive adjusted image data corresponding to the adjustment instructions, and identify the biological structure, in-focus, in the adjusted image data using the selected model. The host device generates annotations corresponding to the identified biological structure and displays the image data and annotations.
Methods and systems for designing a volumetric model of a construct at a user interface through use of a 3-D design, fabrication and assembly system comprising a modeling component, a robotic assembly workstation component, and a workflow configuration module to generate, through the workflow configuration module, a 3-D print bill of materials for a rendered volumetric model; generate a workflow configuration model based on the 3-D print bill of materials, the model including an automated robot control scheme of a series of assembly order instructions to direct a multi-axis robot of the robotic assembly workstation component to print and/or assemble a construct; transmit the workflow configuration model to the robotic assembly workstation component with a print and/or assembly command in accordance with the automated robot control scheme; and print and/or assemble the construct with the multi-axis robot in accordance with the print and/or assembly command.
A 3D printing tool and assembly for dispensing multiple materials includes a barrel holder assembly having at least two barrel orifices extending from a top end of the barrel holder assembly through to a bottom end of the barrel holder assembly, where at least one of the at least two barrel orifices is oriented at an angle from the vertical. A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
A 3D printing tool and assembly for dispensing multiple materials includes a barrel holder assembly having at least two barrel orifices extending from a top end of the barrel holder assembly through to a bottom end of the barrel holder assembly, where at least one of the at least two barrel orifices is oriented at an angle from the vertical. A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.
A temperature controlled dispensing tool includes a mount and a temperature controlled module coupled to the mount. The temperature controlled module may include a barrel housing, a barrel insert, one or more heating element, one or more cooling element, one or more temperature sensors, and a control unit. The barrel insert is removably insertable into the barrel housing and configured to receive a material barrel. The one or more heating elements and the one or more cooling elements are in thermal communication with the barrel insert. The control unit is configured to determine a temperature of the temperature controlled module based on the signal of the one or more temperature sensors, and selectively operate the one or more heating elements and the one or more cooling elements thereby controlling a temperature of the temperature controlled module.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/232 - Driving means for motion along the axis orthogonal to the plane of a layer
A temperature controlled dispensing tool includes a mount and a temperature controlled module coupled to the mount. The temperature controlled module may include a barrel housing, a barrel insert, one or more heating element, one or more cooling element, one or more temperature sensors, and a control unit. The barrel insert is removably insertable into the barrel housing and configured to receive a material barrel. The one or more heating elements and the one or more cooling elements are in thermal communication with the barrel insert. The control unit is configured to determine a temperature of the temperature controlled module based on the signal of the one or more temperature sensors, and selectively operate the one or more heating elements and the one or more cooling elements thereby controlling a temperature of the temperature controlled module.
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
09 - Scientific and electric apparatus and instruments
Goods & Services
Three-dimensional (3-D) printers Laboratory equipment and instruments, namely, computer robotics-supported workstations comprised of integrated multi-axis robots, video cameras, operating software, three-dimensional printers, cartridges for containing printing material, dispenser syringes for laboratory use, and automated conveyance and controlled storage system for biological specimens for use in space and reduced or zero gravity environments
A method for fabricating a cornea includes affixing a frame to at least one cell culture insert comprising a generally cylindrical structure having a proximal end and a distal end, a base disposed at the proximal end, and a porous membrane disposed between the proximal end and the distal end; affixing a dome-shaped member to the porous membrane within the frame, the dome-shaped member comprising a crown, a dome base, and a surface connecting the crown and the dome base; depositing a material comprising a matrix-forming compound on the frame such that the crown and at least a portion of the surface of the dome-shaped member is coated with the material comprising the matrix-forming compound; and removing the dome-shaped member to produce a fabricated cornea attached to the frame. A system for fabricating a cornea and a cornea scaffold are also described herein.
A method for fabricating a cornea includes affixing a frame to at least one cell culture insert comprising a generally cylindrical structure having a proximal end and a distal end, a base disposed at the proximal end, and a porous membrane disposed between the proximal end and the distal end; affixing a dome-shaped member to the porous membrane within the frame, the dome-shaped member comprising a crown, a dome base, and a surface connecting the crown and the dome base; depositing a material comprising a matrix-forming compound on the frame such that the crown and at least a portion of the surface of the dome-shaped member is coated with the material comprising the matrix-forming compound; and removing the dome-shaped member to produce a fabricated cornea attached to the frame. A system for fabricating a cornea and a cornea scaffold are also described herein.
A method for fabricating a cornea includes affixing a frame to at least one cell culture insert comprising a generally cylindrical structure having a proximal end and a distal end, a base disposed at the proximal end, and a porous membrane disposed between the proximal end and the distal end; affixing a dome-shaped member to the porous membrane within the frame, the dome-shaped member comprising a crown, a dome base, and a surface connecting the crown and the dome base; depositing a material comprising a matrix-forming compound on the frame such that the crown and at least a portion of the surface of the dome-shaped member is coated with the material comprising the matrix-forming compound; and removing the dome-shaped member to produce a fabricated cornea attached to the frame. A system for fabricating a cornea and a cornea scaffold are also described herein.
C12M 1/00 - Apparatus for enzymology or microbiology
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
54.
SYSTEMS AND METHODS FOR ISOLATING MICROVESSELS FROM ADIPOSE TISSUE
Methods and systems to isolate microvessels using an enriched or purified enzyme to dissociate tissue are described. The systems and methods include a second digestion to digest a top layer, from a first digestion and first centrifuge operation, with the enriched or purified enzyme to generate a second fat-enzyme solution, a second centrifuge operation, and isolation of the microvessels from pellets generated by the first and second centrifuge operations. The systems and methods may include washing the second fat-enzyme solution with an enzyme inhibitor in a post-digestion wash.
Methods and systems to isolate microvessels using an enriched or purified enzyme to dissociate tissue are described. The systems and methods include a second digestion to digest a top layer, from a first digestion and first centrifuge operation, with the enriched or purified enzyme to generate a second fat-enzyme solution, a second centrifuge operation, and isolation of the microvessels from pellets generated by the first and second centrifuge operations. The systems and methods may include washing the second fat-enzyme solution with an enzyme inhibitor in a post-digestion wash.
According to one or more embodiments, a system for detecting defects in a printed construct includes one or more processors, one or more image sensors, and one or more memory modules. The one or more image sensors are communicatively coupled to the one or more processors. Machine readable instructions are stored on the one or more memory modules that, when executed by the one or more processors, cause the system to collect image data of a three-dimensional printed construct from the one or more image sensors, and detect one or more defects within the image data of the three-dimensional printed construct.
According to one or more embodiments, a system for detecting defects in a printed construct includes one or more processors, one or more image sensors, and one or more memory modules. The one or more image sensors are communicatively coupled to the one or more processors. Machine readable instructions are stored on the one or more memory modules that, when executed by the one or more processors, cause the system to collect image data of a three-dimensional printed construct from the one or more image sensors, and detect one or more defects within the image data of the three-dimensional printed construct.
In one embodiment, a system for biomedical object segmentation includes one or more processors; one or more memory modules communicatively coupled to the one or more processors, and machine readable instructions stored on the one or more memory modules. The machine readable instructions cause the system to perform the following when executed by the one or more processors: receive image data of one or more biological constructs; analyze the image data to generate processed image data via a data analytics module to recognize biomedical objects; and automatically annotate the processed image data to indicate a location of one or more biological objects within the one or more biological constructs.
In one embodiment, a system for biomedical object segmentation includes one or more processors; one or more memory modules communicatively coupled to the one or more processors, and machine readable instructions stored on the one or more memory modules. The machine readable instructions cause the system to perform the following when executed by the one or more processors: receive image data of one or more biological constructs; analyze the image data to generate processed image data via a data analytics module to recognize biomedical objects; and automatically annotate the processed image data to indicate a location of one or more biological objects within the one or more biological constructs.
Modular pump assemblies according to the present disclosure include a plurality of mounting frames configured to be stackable with one another in a modular configuration, and an array of pumps mounted to each of the plurality mounting frames, the array of pumps comprising an array of inlet pumps configured to be fluidically coupled a plurality of fluid inlet paths of a well-plate manifold or an array of fluid outlet pumps configured to be fluidically coupled to a plurality of fluid outlet paths of the well-plate manifold, or any combination thereof.
Modular pump assemblies according to the present disclosure include a plurality of mounting frames configured to be stackable with one another in a modular configuration, and an array of pumps mounted to each of the plurality mounting frames, the array of pumps comprising an array of inlet pumps configured to be fluidically coupled a plurality of fluid inlet paths of a well-plate manifold or an array of fluid outlet pumps configured to be fluidically coupled to a plurality of fluid outlet paths of the well-plate manifold, or any combination thereof.
Industrial robots, conveyors being machines, and machines for sorting, namely, grippers, graspers and end effectors for use with 3D printers for printing biologic tissue and biologic materials
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Biological tissue, namely, human adipose cells for use in scientific and medical research; Biological tissue, namely, human microvessels for laboratory use
42 - Scientific, technological and industrial services, research and design
Goods & Services
Research and development for new products and services for others, in the field of medicines and treatments for diseases, disorders and injuries in humans and animals
66.
MODULAR STORAGE UNITS FOR PERFUSION AND/OR INCUBATION OF ONE OR MORE SPECIMENS AND STORAGE ASSEMBLIES
A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.
A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.
A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.
Methods and systems for designing a volumetric model of a construct at a user interface through use of a 3-D design, fabrication and assembly system comprising a modeling component, a robotic assembly workstation component, and a workflow configuration module to generate, through the workflow configuration module, a 3-D print bill of materials for a rendered volumetric model; generate a workflow configuration model based on the 3-D print bill of materials, the model including an automated robot control scheme of a series of assembly order instructions to direct a multi-axis robot of the robotic assembly workstation component to print and/or assemble a construct; transmit the workflow configuration model to the robotic assembly workstation component with a print and/or assembly command in accordance with the automated robot control scheme; and print and/or assemble the construct with the multi-axis robot in accordance with the print and/or assembly command.
G05B 19/4099 - Surface or curve machining, making 3D objects, e.g. desktop manufacturing
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
Methods and systems for designing a volumetric model of a construct at a user interface through use of a 3-D design, fabrication and assembly system comprising a modeling component, a robotic assembly workstation component, and a workflow configuration module to generate, through the workflow configuration module, a 3-D print bill of materials for a rendered volumetric model; generate a workflow configuration model based on the 3-D print bill of materials, the model including an automated robot control scheme of a series of assembly order instructions to direct a multi-axis robot of the robotic assembly workstation component to print and/or assemble a construct; transmit the workflow configuration model to the robotic assembly workstation component with a print and/or assembly command in accordance with the automated robot control scheme; and print and/or assemble the construct with the multi-axis robot in accordance with the print and/or assembly command.
Methods and systems for designing a volumetric model of a construct at a user interface through use of a 3-D design, fabrication and assembly system comprising a modeling component, a robotic assembly workstation component, and a workflow configuration module to generate, through the workflow configuration module, a 3-D print bill of materials for a rendered volumetric model; generate a workflow configuration model based on the 3-D print bill of materials, the model including an automated robot control scheme of a series of assembly order instructions to direct a multi-axis robot of the robotic assembly workstation component to print and/or assemble a construct; transmit the workflow configuration model to the robotic assembly workstation component with a print and/or assembly command in accordance with the automated robot control scheme; and print and/or assemble the construct with the multi-axis robot in accordance with the print and/or assembly command.
09 - Scientific and electric apparatus and instruments
Goods & Services
Cell and tissue culture system for laboratory use comprising a fluidics control apparatus and structural component parts therefor for controlling fluid and media delivery to biological tissue, cell cultures and biological specimens; Laboratory apparatus and instruments, namely, microfluidic apparatus and devices and customizable fluid control manifolds for controlling fluid and media delivery to tissue, cell cultures and biologic material
73.
Methods and systems for 3D printing with a 3D printing platform including printing tool coupling components
Methods and systems for 3D printing use a 3D printing device defined by a polar coordinate frame including an r-axis, a z-axis, and a rotational theta axis. The device includes a base, a rotatably attached printing stage is rotatably attached, a z-axis aligned pair of towers, an r-axis aligned rail slidably coupled to the towers, a print head slidably disposed on the rail, a printing tool coupling component (“master”) joined to the print head, and a rotatable tool carousel with bays housing printing tools, each including a printing tool body (“slave”). The slave may be coupled with and locked to or unlocked from the master to form a coupled tool assembly through a mechanical actuation assembly. With the coupled tool assembly, a printing tool is removable from a respective bay when the coupled tool assembly moves along the r-axis in a direction opposite from the rotatable tool carousel.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
Methods and systems for 3D printing use a 3D printing device defined by a polar coordinate frame including an r-axis, z-axis, and rotational theta axis. The device includes a base, a rotatably attached printing stage is rotatably attached, a z-axis aligned pair of towers, an r-axis aligned rail slidably coupled to the towers, a print head slidably disposed on the rail, printing tool coupling component ("master") joined to the print head, and a rotatable tool carousel with bays housing printing tools, each including a printing tool body ("slave"). The slave may be coupled with and locked to or unlocked from the master to form a coupled tool assembly through a mechanical actuation assembly. With the coupled tool assembly, a printing tool is removable from a respective bay when the coupled tool assembly moves along the r-axis in a direction opposite from the rotatable tool carousel.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
75.
END EFFECTOR CALIBRATION ASSEMBLIES, SYSTEMS, AND METHODS
An end effector calibration assembly includes an electronic controller, a first camera assembly communicatively coupled to the electronic controller, and a second camera assembly communicatively coupled to the electronic controller. A first image capture path of the first camera assembly intersects a second image capture path of the second camera assembly. The electronic controller receives image data from the first camera assembly, receives image data from the second camera assembly, and calibrates a position of the robot end effector based on the image data received from the first camera assembly and the second camera assembly.
Methods and systems for 3D printing use a 3D printing device defined by a polar coordinate frame including an r-axis, z-axis, and rotational theta axis. The device includes a base, a rotatably attached printing stage is rotatably attached, a z-axis aligned pair of towers, an r-axis aligned rail slidably coupled to the towers, a print head slidably disposed on the rail, printing tool coupling component ("master") joined to the print head, and a rotatable tool carousel with bays housing printing tools, each including a printing tool body ("slave"). The slave may be coupled with and locked to or unlocked from the master to form a coupled tool assembly through a mechanical actuation assembly. With the coupled tool assembly, a printing tool is removable from a respective bay when the coupled tool assembly moves along the r-axis in a direction opposite from the rotatable tool carousel.
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
An end effector calibration assembly includes an electronic controller, a first camera assembly communicatively coupled to the electronic controller, and a second camera assembly communicatively coupled to the electronic controller. A first image capture path of the first camera assembly intersects a second image capture path of the second camera assembly. The electronic controller receives image data from the first camera assembly, receives image data from the second camera assembly, and calibrates a position of the robot end effector based on the image data received from the first camera assembly and the second camera assembly.
An end effector calibration assembly includes an electronic controller, a first camera assembly communicatively coupled to the electronic controller, and a second camera assembly communicatively coupled to the electronic controller. A first image capture path of the first camera assembly intersects a second image capture path of the second camera assembly. The electronic controller receives image data from the first camera assembly, receives image data from the second camera assembly, and calibrates a position of the robot end effector based on the image data received from the first camera assembly and the second camera assembly.
A well-plate assembly includes a well-plate defining an array of wells and a fluidic manifold assembly fitted to the array of wells and configured to direct a fluid into each well of the well plate.
A well-plate assembly includes a well-plate defining an array of wells and a fluidic manifold assembly fitted to the array of wells and configured to direct a fluid into each well of the well plate.
An automated conveyance and controlled storage system for biological specimens sold as a component of a 3-D printer primarily composed of hardware in the nature of heaters, trays, containers, sensors, flow pumps, temperature monitors, conveyors and environmental controls that control and maintain environmental conditions to support biological specimens and biologic materials, and hardware in the nature of heaters, trays, containers, sensors, flow pumps, temperature monitors, conveyors and environmental controls that induce and control fluidic flow and cellular and tissue perfusion, and hardware in the nature of containers, trays, sensors and conveyors that transit wellplates, petri dishes, and other cellular and tissue storage vessels throughout the controlled storage system
High-throughput column arrays of vascularized living parenchyma / tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
High-throughput column arrays of vascularized living parenchyma / tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
84.
System and workstation for the design, fabrication and assembly of bio-material constructs
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non-biological constructs. The robotic bioassembly workstation includes a six-axis robot providing the capability for oblique-angle printing, printing by non-sequential planar layering, and printing on print substrates having variable surface topographies, enabling fabrication of more complex bio-constructs including tissues, organs and vascular trees.
Multi-component fluid mixing devices and methods of manufacturing and using such multi-component fluid mixing devices are provided. The multi-component fluid mixing devices include one or both of a serpentine flow path and an attachment point decoupled from an inlet of the multi-component fluid mixing devices. The method of use includes switching between multi-component fluid mixing devices with different length flow paths, while retaining a constant position of the outlet of the multi-component fluid mixing devices. A manufacturing method includes fusing two halves of a multi-component fluid mixing device together with mixing elements in a serpentine flow path captured in a mixer wall formed between the two halves of the multi-component fluid mixing device.
Multi-component fluid mixing devices and methods of manufacturing and using such multi-component fluid mixing devices are provided. The multi-component fluid mixing devices include one or both of a serpentine flow path and an attachment point decoupled from an inlet of the multi-component fluid mixing devices. The method of use includes switching between multi-component fluid mixing devices with different length flow paths, while retaining a constant position of the outlet of the multi-component fluid mixing devices. A manufacturing method includes fusing two halves of a multi-component fluid mixing device together with mixing elements in a serpentine flow path captured in a mixer wall formed between the two halves of the multi-component fluid mixing device.
Systems and methods for a robotic fabrication and assembly platform providing a plurality of printable materials for fabrication of a three-dimensional object are provided. A method includes activating a pneumatic actuator to extend a quick-change turret from a pneumatic seal. The method may insert a plurality of barrels into the quick-change turret. The method may also align one of the plurality of barrels with a pneumatic seal in the quick-change turret. The method may also disengage the pneumatic actuator to seat the aligned barrel onto the pneumatic seal and print a three-dimensional object. The method may further halt the printing of the three-dimensional object prior to completion and engage the pneumatic actuator to extend the quick-change turret from the pneumatic seal.
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
88.
System and method for a quick-change material turret in a robotic fabrication and assembly platform
Systems and methods for a robotic fabrication and assembly platform providing a plurality of printable materials for fabrication of a three-dimensional object are provided. A method includes activating a pneumatic actuator to extend a quick-change turret from a pneumatic seal. The method may insert a plurality of barrels into the quick-change turret. The method may also align one of the plurality of barrels with a pneumatic seal in the quick-change turret. The method may also disengage the pneumatic actuator to seat the aligned barrel onto the pneumatic seal and print a three-dimensional object. The method may further halt the printing of the three-dimensional object prior to completion and engage the pneumatic actuator to extend the quick-change turret from the pneumatic seal.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/232 - Driving means for motion along the axis orthogonal to the plane of a layer
A bona fide adaptable in vitro microcirculation model is provided by integrating a 3-D printed network of endothelial-cell lined perfusion channels, formed via sacrificial casting in a gel matrix, with a native, adaptable microvasculature matured from native microvessels added to the gel matrix. Responsive vascular adaptation exhibited by the in vitro microcirculation is physiologically relevant. Methods for fabricating, devices, models and investigative platforms for pharmaceutical applications, vascular mechanism and microvessel-parenchyma interaction studies, and vascularizing strategies for tissue engineering applications are also disclosed.
A bona fide adaptable in vitro microcirculation model is provided by integrating a 3-D printed network of endothelial-cell lined perfusion channels, formed via sacrificial casting in a gel matrix, with a native, adaptable microvasculature matured from native microvessels added to the gel matrix. Responsive vascular adaptation exhibited by the in vitro microcirculation is physiologically relevant. Methods for fabricating, devices, models and investigative platforms for pharmaceutical applications, vascular mechanism and microvessel-parenchyma interaction studies, and vascularizing strategies for tissue engineering applications are also disclosed.
A bona fide adaptable in vitro microcirculation model is provided by integrating a 3-D printed network of endothelial-cell lined perfusion channels, formed via sacrificial casting in a gel matrix, with a native, adaptable microvasculature matured from native microvessels added to the gel matrix. Responsive vascular adaptation exhibited by the in vitro microcirculation is physiologically relevant. Methods for fabricating, devices, models and investigative platforms for pharmaceutical applications, vascular mechanism and microvessel-parenchyma interaction studies, and vascularizing strategies for tissue engineering applications are also disclosed.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Integrated suite of software for use in conjunction with three-dimensional (3-D) printers, laboratory equipment, and instruments, namely, computer robotics-supported workstations, comprising three-dimensional printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras, software, and automated conveyance and controlled storage system for biological specimens; downloadable computer software for use in conjunction with three-dimensional (3-D) printers, laboratory equipment, and instruments, namely, computer robotics-supported workstations, comprising three-dimensional printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras, software, and automated conveyance and controlled storage system for biological specimens; Computer application software for mobile phones, namely, software for use in conjunction with three-dimensional (3-D) printers, laboratory equipment, and instruments, namely, computer robotics-supported workstations, comprising three-dimensional printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras, software, and automated conveyance and controlled storage system for biological specimens Software as a service (SAAS) services featuring software for use in conjunction with three-dimensional (3-D) printers, laboratory equipment, and instruments, namely, computer robotics-supported workstations, comprising three-dimensional printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras, software, and automated conveyance and controlled storage system for biological specimens
09 - Scientific and electric apparatus and instruments
Goods & Services
Computer robotics-supported workstations comprising three-dimensional (3D) printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras and software for visualization of workstation operations, sensors and software for environmental control of workstation, for fabricating and assembling engineered tissue constructs
94.
System and workstation for the design, fabrication and assembly of bio-material constructs
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non-biological constructs. The robotic bioassembly workstation includes a six-axis robot providing the capability for oblique-angle printing, printing by non-sequential planar layering, and printing on print substrates having variable surface topographies, enabling fabrication of more complex bio-constructs including tissues, organs and vascular trees.
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non- biological constructs. The robotic bioassembly workstation includes a six-axis robot providing the capability for oblique-angle printing, printing by non-sequential planar layering, and printing on print substrates having variable surface topographies, enabling fabrication of more complex bio-constructs including tissues, organs and vascular trees.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/00 - Data acquisition or data processing for additive manufacturing
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non- biological constructs. The robotic bioassembly workstation includes a six-axis robot providing the capability for oblique-angle printing, printing by non-sequential planar layering, and printing on print substrates having variable surface topographies, enabling fabrication of more complex bio-constructs including tissues, organs and vascular trees.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
09 - Scientific and electric apparatus and instruments
Goods & Services
Computer robotics-supported workstations comprising three-dimensional (3D) printers, multi-axis robots, cartridges for containing printing material, dispensers, video cameras and software for visualization of workstation operations, sensors and software for environmental control of workstation, for fabricating and assembling engineered tissue constructs
