Abstract

A cardiac device is provided including a measuring electrode, a signal-processing unit and a post-processing unit. The measuring electrode is adapted to be positioned within the blood pool of a human or an animal heart, in order to measure a depolarization-signal. The signal-processing unit is connected to the measuring electrode and is adapted to remove signal components with frequencies lower than a cut-off frequency from the measured depolarization-signal. The post-processing unit is connected to the signal-processing unit and is adapted to determine, based on the Brody effect, a measure for a ventricular volume of the heart based on the modified depolarization-signal. Furthermore, a method for the determination of a measure for a ventricular volume of a heart and a computer program product for performing the steps of this method are provided.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
• A61B 5/0265 - Measuring blood flow using electromagnetic means, e.g. electromagnetic flow meter
• A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• A61M 60/523 - Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
• A61M 60/876 - Implantable batteries
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

A cardiac device is provided comprising a measuring electrode (3), a signal-processing unit (41,87) and a post-processing unit (43,45). The measuring electrode (3) is adapted to be positioned within the blood pool (16) of a human or an animal heart (1), in order to measure an depolarization-signal (61). The signal-processing unit (41,87) is connected to the measuring electrode (3) and is adapted to remove signal components with frequencies lower than a cut-off frequency from the measured depolarization-signal (61). The post-processing unit (43,5) is connected to the signal-processing unit (41,87) and is adapted to determine, based on the Brody effect, a measure (46) for a ventricular volume of the heart (1) based on the modified depolarization-signal (42; 5). Furthermore, a method for the determination of a measure for a ventricular volume of a heart (1) and a computer program product for performing the steps of this method are provided.

IPC Classes  ?

• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
• A61B 5/0402 - Electrocardiography, i.e. ECG
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Goods & Services

Electronic publications, downloadable; Apparatus for the recording, transmission or reproduction of sound, images and data; Machine-readable data carriers of all kinds, containing recorded data; Data processing apparatus and computers, including data processing apparatus and computers being components for data networks and parts facilitating data network communications; Software. Teaching materials [except apparatus]; Printed matter, in particular pamphlets, Guides, Flyers, Informational sheets, Check-lists, Newspapers and magazines, books, Printed teaching materials, Printed guides, Posters made of paper, Events programmes. Database services, including online databases and including databases on data carriers, namely the gathering and updating of data and other information. Training, further training and continuing education, in particular in the field of medical informatics, healthcare and nursing, technical operative assistance, technical medical assistance, cardio technology, cardiovascular magnetic resonance imaging, perioperative echocardiography, Intensive care, Anesthesia, Paediatric intensive care, heart, thorax and vascular surgery, cardio anaesthesia, paediatric cardio surgery, paediatric cardiology, cardiology, angiology; Publications in the field of medicine and science; Providing electronic publications; Publication of printed matter; Publishing of electronic publications, including in electronic form and on the internet; Providing of newsletters via email; Planning, organisation, conducting and arranging of seminars, courses, training courses, lectures, workshops, meetings, symposiums, conferences and academic events. Science, research and development services- Including within the framework of international cooperation in the fields of heart, thorax and vascular surgery, cardio anaesthesia, paediatric cardio surgery, paediatric cardiology, cardiology, angiology, psychosomatics, medical and cardio-technology, medical information technology, Medical and hygienic care; Scientific and industrial research; Drawing up of scientific expert reports; Scientific consultancy services; Research and development services; Scientific research; Design and development of medical technology; Design and development of computer software for use with medical technology; Medical research; Preparation of data processing programmes, Including programs in connection with data carriers or data networks; Database services, including online databases and databases on data carriers, namely the delivery of data and other information and the brokerage of database information relating to scientific and medical research and development, relating to the design and development of computer software for medical technology; Database services, including online databases and databases on data carriers, namely the storage of data and other information. Hospital services; The operation of facilities for inpatient and outpatient care and promoting public healthcare; Medical services, In particular in the fields of heart, thorax and vascular surgery, cardio anaesthesia, paediatric cardio surgery, paediatric cardiology, Cardiology, Angiology, Psychosomatics; Medical care; Medical services; Drawing up of expert reports by doctors; Medical consultancy; Dietetic advisory services.

Abstract

The invention relates to an artificial heart-assist pump having a pump body (1), an outflow connection (5) and an outflow arrangement (9), which is fastened to the outflow connection (5), wherein the outflow arrangement (9) has an outflow graft (6), a fastening stub (7), which is connected to the connection graft (6) for conjoint rotation therewith, and a union nut (8), which is arranged on the fastening stub (7) and by means of which the outflow arrangement (9) is fastened on the outflow connection (5). The artificial heart-assist pump (10) is distinguished in that it also has a fixing element (13) with a first fixing region (20) and a second fixing region (21), which cannot be moved in relation to the first fixing region (20), wherein the first fixing region (20) is in rotationally fixed engagement with the union nut (8) and the second fixing region (21) is in rotationally fixed engagement with the fastening stub (7), and therefore the fastening stub (7) cannot be moved relative to the union nut (8).

IPC Classes  ?

• A61M 1/10 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
• A61M 1/12 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps implantable into the body

Abstract

It is provided a device for the transcutaneous implantation of an epicardial pacemaker electrode, which is arranged in a tubular, flexible implantation catheter insertable into the pericardial space. The distal end area of the electrode is connected to a shape-variable element for aligning the electrode, in particular for adjusting the implantation angle thereof, and for stabilizing, in particular laterally stabilizing, the electrode.

IPC Classes  ?

• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
• A61B 17/34 - TrocarsPuncturing needles
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The invention relates to a device for implanting a self-expandable stent in a hollow organ. For the transluminal insertion and deployment of a self-expandable stent, in particular of a heart valve stent, in a hollow organ, the stent is arranged in a compressed state at the distal end of a tubular, flexible implantation catheter (2), which has a tubular outer catheter (5), an inner catheter (4), and a tube-ring shaped helical tension spring (6) arranged between the outer catheter (5) and the inner catheter (4), which tension spring (6) supports the proximal end of the stent by means of the distal end of the tension spring (6). The stent is deployed at the implantation site to bear on the hollow organ by retracting the outer catheter (5) with respect to the helical tension spring (6), which is pre-stressed with respect to the outer catheter (5) in the direction of the proximal end of the implantation catheter (2), or the distal end thereof with respect to the outer catheter (5) is retracted by a measure that is greater than the axial length of the stent. Fig. 3

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod

Abstract

The invention relates to a device for the transcutaneous implantation of an epicardial pacemaker electrode (5), which is guided in a tubular, flexible external catheter (2) of an implantation catheter (1) that can be inserted into the gap of the pericardium (Pkh). According to the invention, the distal end portion of the electrode (4) is connected to a shape-variable element (6) for aligning, in particular for adjusting the implantation angle, and for stabilizing, in particular for laterally stabilizing the electrode (5).

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The present invention is directed to a method for use in conducting cardiac MR imaging which allows for reconstruction of T1 maps, cine images and IR-prepared images from one raw data set, wherein the method comprises the following steps: a) acquisition of raw data by use of an ECG-triggered, segmented, inversion recovery (IR)-prepared Look-Locker type pulse sequence for data acquisition, wherein the pulse sequence encompasses more than one shot, wherein each shot comprises: i) an ECG-triggered inversion pulse; ii) SSFP cine data acquisition of radial segmented profiles over more than one RR-interval for a predefined acquisition duration AD; and iii) a relaxation duration RD, during which no data is acquired; b) retrospective gating of raw data by sorting acquired raw data for each RR-interval into a pre-determined number of heart phases by definition of specific time windows within the RR-intervals and sampling of raw data acquired during the time windows respectively; c) image reconstruction, wherein the retrospectively gated raw data is used for reconstruction of T1 maps, cine images and/or IR-prepared images.

IPC Classes  ?

• G01R 33/50 - NMR imaging systems based on the determination of relaxation times
• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

The application relates to peptides and nucleic acid molecules encoding peptides which interact with autoantibodies associated with coronary arterial occlusion, angina pectoris, pulmonary hypertension, occlusion of peripheral arterial vessels, Raynaud syndrome and scleroderma, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said peptides - especially in apheresis - for the treatment of coronary arterial occlusion, angina pectoris, pulmonary hypertension, occlusion of peripheral arterial vessels, Raynaud syndrome and scleroderma. The peptides of the application are minimally capable of binding the endothelin-1-receptor and for selected diseases additionally the protease-activated- receptor 1, 2 or 3 or the alphal-adrenergic-receptor.

IPC Classes  ?

• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 37/00 - Drugs for immunological or allergic disorders
• C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
• C07K 14/72 - ReceptorsCell surface antigensCell surface determinants for hormones
• C07K 14/575 - Hormones
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Goods & Services

Providing of training, education and further training in medical information technology; publications in the field of medicine and science. Providing equipment for in-patient and out-patient care and support for public health matters, including science, research and development (including the aforesaid services within the framework of international cooperation) in the fields of heart, thorax and vascular surgery, cardio-anaesthesia, infant cardio-surgery, infant cardiology, cardiology, angiology, medical and cardio-technology, medical information technology; medical and hygienic care; scientific and industrial research; providing medical and scientific expertise; consultancy for medical and scientific matters.

Goods & Services

Apparatus for recording, transmission or reproduction of sound, images and data; machine-readable data carriers of all types containing recorded data; data processing apparatus and computers, including data processing apparatus and computers being components for data networks and parts facilitating data network communications; computer software. Providing of training, education and further training in medical information technology; publications in the field of medicine and science. Providing equipment for in-patient and out-patient care and support for public health matters, including science, research and development (including the aforesaid services within the framework of international co-operation) in the fields of heart, thorax and vascular surgery, cardio-anaesthesia, infant cardio-surgery, infant cardiology, cardiology, angiology, medical and cardio-technology, medical information technology; medical and hygienic care; scientific and industrial research; providing medical and scientific expertise; consultancy for medical and scientific matters; computer programming for data processing, including programs for data carriers and data networks; databases, including on-line databases, including databases on data carriers, namely the gathering, storing, updating and supplying of data and other information and managing database information.

Goods & Services

Apparatus for recording, transmission or reproduction of sound, images and data; machine-readable data carriers of all types containing recorded data; data processing apparatus and computers, including data processing apparatus and computers being components for data networks and parts facilitating data network communications; computer software. Providing of training, education and further training in medical information technology; publications in the field of medicine and science. Providing equipment for in-patient and out-patient care and support for public health matters, including science, research and development (including the aforesaid services within the framework of international co-operation) in the fields of heart, thorax and vascular surgery, cardio-anaesthesia, infant cardio-surgery, infant cardiology, cardiology, angiology, medical and cardio-technology, medical information technology; medical and hygienic care; scientific and industrial research; providing medical and scientific expertise; consultancy for medical and scientific matters; computer programming for data processing, including programs for data carriers and data networks; databases, including on-line databases, including databases on data carriers, namely the gathering, storing, updating and supplying of data and other information and managing database information.