Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes first logic to generate a first command frame including a flag having a first value and second logic to transmit the first command frame to a first device. The first value indicates that the first device should ignore an operation indicated by the first command frame. The scientific instrument support apparatus includes third logic to determine whether a confirmation signal indicating a successful operation is received and fourth logic to generate, when the confirmation signal is received, a second command frame including the flag having a second value. The second value indicates that the first device should perform an operation indicated by the second command frame.
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a system for performing scientific instrument support is provided. The system, which may be implemented by a common computing device included a scientific instrument or remote from the scientific instrument or implemented by a plurality of computing devices included in the scientific instrument, remote from the scientific instrument, or a combination thereof, is configured to parse, with a data collector service, a template associated with a scientific instrument to extract a schema for the scientific instrument. The system is further configured to query, with the data collector service, the scientific instrument according to the schema. The system is further configured to receive data from the scientific instrument responsive to the query. An automated method performed via a computing device for providing such scientific instrument support is also provided.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
DIONEX CORPORATION (USA)
Inventor
Hadfield, Maximillian Spencer
Schroeder, Tara L.
Lin, Linda Xueying
Rehman, Misbah
Cao, Yu
Cardasis, Helene L.
Zhou, Yu
Kenny, Patrick
Yuen, Waiming
Schauer, Kevin
Abstract
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
THERMO FINNIGAN LLC (USA)
DIONEX CORPORATION (USA)
Inventor
Hadfield, Maximillian
Schroeder, Tara
Lin, Linda
Rehman, Misbah
Cao, Yu
Cardasis, Helene
Zhou, Yu
Yuen, Waiming
Kenny, Patrick
Schauer, Kevin
Abstract
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.
Systems and methods taught herein include a peristaltic pump placed along a regenerant flow path to supply regenerant fluid to ion exchange devices (such as chemical suppressors) and other devices within a chromatography system. The peristaltic pump provides steady and highly controllable flow rates that improve run-to-run reproducibility within the system and does not require that the regenerant supply be placed under pressure. Some systems and methods taught herein use peristaltic pumps to enable steady delivery of other fluids, such as water, to related systems such as ion exchange devices operating in electrolytic mode.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
THERMO FISHER SCIENTIFIC INDIA PRIVATE LIMITED (India)
DIONEX CORPORATION (USA)
Inventor
Al-Esawi, Husam
Gleave, Gary
Honegger, Andres
Vadlapudi, Ravi Kanth
Mohammed, Gaffar
Patil, Vivek R.
Abstract
Systems and methods taught herein provide an eluent level sensor that enables real-time monitoring of the level of eluent or waste liquid in a container placed on the eluent level sensor. The eluent level sensor alerts the user when the eluent liquid level is below or above a selectable threshold as appropriate to the particular contents of the container. For example, the eluent level sensor can alert the user when the eluent liquid level falls below the selectable threshold for a container holding new eluent or eluent precursor. In the eluent delivery systems, as the user is alerted before the container is empty, it helps the user to save a lot of analysis time and effort. By giving notification (e.g., visual notification) to the user of the eluent level, the eluent level sensor can avoid damage to instrumentation and improve user experience.
G01F 23/00 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
G01F 23/20 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measurement of weight, e.g. to determine the level of stored liquefied gas
G01F 25/20 - Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume of apparatus for measuring liquid level
Gas control devices, and associated methods and systems, are described herein. In one aspect, a method can include determining whether at least one of (1) a characteristic C1 associated with gas entering a gas valve and (2) a characteristic C2 associated with gas exiting the gas valve satisfies a condition, the gas valve being fluidically coupled to a gas regulator and a gas output, and the gas valve being convertible among at least (1) a first state in which the gas regulator and the gas output are placed into fluid communication with one another and (2) a second state in which the gas regulator and the gas output are placed into fluid isolation from one another; and based on the determining, causing the gas valve to convert from one of the first state to the other of the second state.
G05D 7/06 - Control of flow characterised by the use of electric means
F17C 13/00 - VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES - Details of vessels or of the filling or discharging of vessels
8.
ULTRA-WIDE DYNAMIC RANGE DIFFERENTIAL CONDUCTIVITY DETECTOR CIRCUIT FOR ION CHROMATOGRAPHY
A conductivity detector module for an ion chromatography system includes a detector cell configured to receive an eluent stream from the ion chromatography system, the detector cell including a first electrode and a second electrode in electrical contact with the eluent stream; a first current branch coupled to a first cell drive input and to the first electrode and providing a first cell output; and a second current branch coupled to a second cell drive input and to the second electrode and providing a second cell output, wherein the first cell drive input and the second cell drive input are of equal magnitude and opposite sign.
9.
ULTRA-WIDE DYNAMIC RANGE DIFFERENTIAL CONDUCTIVITY DETECTOR CIRCUIT FOR ION CHROMATOGRAPHY
A conductivity detector module for an ion chromatography system includes a detector cell configured to receive an eluent stream from the ion chromatography system, the detector cell including a first electrode and a second electrode in electrical contact with the eluent stream; a first current branch coupled to a first cell drive input and to the first electrode and providing a first cell output; and a second current branch coupled to a second cell drive input and to the second electrode and providing a second cell output, wherein the first cell drive input and the second cell drive input are of equal magnitude and opposite sign.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
10.
PARALLEL PROCESSING AND HORIZONTAL SCALING FOR PEAK DETECTION
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus may include: first logic to receive, from a mass spectrometer, injections data for each of a plurality of injections associated with a sample; second logic to determine peak data for each of the plurality of injections by executing, in parallel on a node, a peak detection algorithm for each of the plurality of injections, third logic to collate the peak data for each of the plurality of injections; and fourth logic to provide the collated peak data for further processing.
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus may include: first logic to receive, from a mass spectrometer, injections data for each of a plurality of injections associated with a sample; second logic to determine peak data for each of the plurality of injections by executing, in parallel on a node, a peak detection algorithm for each of the plurality of injections, third logic to collate the peak data for each of the plurality of injections; and fourth logic to provide the collated peak data for further processing.
An electrolytic eluent generator system includes a flow-through eluent generating zone, a first reservoir comprising configured to hold a first ion source; a second reservoir configured to hold a second ion source; a first ion exchange connector disposed between the first reservoir and the eluent generating zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said first ions; and a second ion exchange connector disposed between the second reservoir and the eluent generation zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said second ions. The second ion exchange connector is of opposite charge to the first ion exchange connector.
Systems and methods under the present disclosure can provide communication between instruments or resources at multiple locations. One example is a system of interconnection for various types of assets at multiple laboratories in different locations. Assets, devices, resources, or services at a location can multicast a beacon identifying itself. Verification of the asset, etc., can be done by communicating with a URI associated with that asset. Authentication of assets can be token-based to enable communication. Proxy servers at all or some of the locations can manage authentication and communication between locations and between assets. Tunnels can be implemented between different locations to help ensure secure communication.
Systems and methods are described for ion chromatography systems and electrolytic suppressors. By varying the operating frequency of an electrolytic suppressor, the generation of bubbles and noise can be minimized. This leads to more accurate results in e.g., a conductivity detector downstream of an electrolytic suppressor within an ion chromatography system. In certain embodiments, it has been found that frequencies of around 700-750 Hz, 100-150 Hz and 925-975 Hz have achieved the best results.
G01N 30/14 - Preparation by elimination of some components
B01D 15/24 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
A method for making modified latex particles, wherein the particles comprise condensation polymers bonded to functional groups on the latex particles and the method for forming the condensation polymer comprises reacting the amino groups present on the latex particles with (i) at least a first polyfunctional compound, having at least two functional moieties reactive with said functional groups of the latex, or (ii) at least a first polyfunctional compound, having at least two functional moieties reactive with said functional groups of the latex and at least a first amine compound, comprising amino groups selected from the group consisting of ammonia, a primary and a secondary amine to form a first condensation polymer reaction product comprising ion exchanging sites and a first unreacted excess of functional moieties.
An eluent generation module includes an electrolytic gas generator and an electrolytic eluent generator. The electrolytic gas generator includes a generation chamber having an inlet and an outlet; an outlet electrode within the generation chamber; a first ion exchange connector; a bulk solvent chamber separated from the generation chamber by the ion exchange connector; and a bulk solvent chamber electrode within the bulk solvent chamber. The electrolytic eluent generator includes an electrolyte chamber containing an aqueous electrolyte solution; an electrolyte chamber electrode within the electrolyte chamber; a second ion exchange connector; an eluent generation chamber separated from the electrolyte chamber by the second ion exchange connector; and an eluent generation chamber electrode.
A method for making modified latex particles, wherein the particles comprise condensation polymers bonded to functional groups on the latex particles and the method for forming the condensation polymer comprises reacting the amino groups present on the latex particles with (i) at least a first polyfunctional compound, having at least two functional moieties reactive with said functional groups of the latex, or (ii) at least a first polyfunctional compound, having at least two functional moieties reactive with said functional groups of the latex and at least a first amine compound, comprising amino groups selected from the group consisting of ammonia, a primary and a secondary amine to form a first condensation polymer reaction product comprising ion exchanging sites and a first unreacted excess of functional moieties.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
An eluent generation module includes an electrolytic gas generator and an electrolytic eluent generator. The electrolytic gas generator includes a generation chamber having an inlet and an outlet; an outlet electrode within the generation chamber; a first ion exchange connector; a bulk solvent chamber separated from the generation chamber by the ion exchange connector; and a bulk solvent chamber electrode within the bulk solvent chamber. The electrolytic eluent generator includes an electrolyte chamber containing an aqueous electrolyte solution; an electrolyte chamber electrode within the electrolyte chamber; a second ion exchange connector; an eluent generation chamber separated from the electrolyte chamber by the second ion exchange connector; and an eluent generation chamber electrode.
A detection cell for a chromatography system, the detection cell includes a cell body including a counter electrode in the form of the cell body or a wire; a working electrode block including a working electrode; a gasket separating the working electrode block from the cell body, the gasket defining a sample flow pathway extending between an inlet and an outlet of the detection cell and in fluid contact with the cell body, the counter electrode, and the working electrode; and a reference electrode system in fluidic contact with the outlet and including a platinum auxiliary electrode operably connected to a positive pole of a power supply and a platinum reference electrode operably connected to a negative pole of the power supply.
The present invention relates to, in general, a disposable electrically insulating substrate surface comprising a platinum hydrogen reference electrode system structure, the use of such a substrate in a flow-through electrochemical cell assembly and methods of manufacturing said substrate. For example, in some embodiments, a disposable electrically insulating substrate surface comprising a platinum hydrogen reference electrode system structure, wherein the platinum hydrogen reference electrode system comprises an electrically conductive and electrochemically active platinum hydrogen reference electrode system region bound as a layer, directly or indirectly, to said substrate surface.
A pH gradient mobile phase preparation kit is described. The preparation kit includes a first component and a second component. The first component includes a first reagent separate from a second reagent. The first reagent, the second reagent, and a solvent together provide a volatile buffer solution having a low pH. The second component includes a base. The base mixed in the solvent provide a volatile base solution having a high pH. A method of separating and detecting one or more analytes comprised in a matrix of components in a sample, using the kit is also described.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
23.
METHOD FOR THE SEPARATION OF ANIONIC, CATIONIC, NEUTRAL AND ZWITTERIONIC ARSENIC SPECIES
A method comprising separating a plurality of arsenic species using a mixed mode column and a strong acid. The plurality of arsenic species includes at least one of each of an anionic arsenic species, a cationic arsenic species, a neutral arsenic species, and a zwitterionic arsenic species.
C02F 1/28 - Treatment of water, waste water, or sewage by sorption
B01J 8/08 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with moving particles
24.
METHOD FOR THE SEPARATION OF ANIONIC, CATIONIC, NEUTRAL AND ZWITTERIONIC ARSENIC SPECIES
A method comprising separating a plurality of arsenic species using a mixed mode column and a strong acid. The plurality of arsenic species includes at least one of each of an anionic arsenic species, a cationic arsenic species, a neutral arsenic species, and a zwitterionic arsenic species.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 39/05 - Processes using organic exchangers in the strongly acidic form
A detection cell for a chromatography system, the detection cell includes a cell body including a counter electrode in the form of the cell body or a wire; a working electrode block including a working electrode; a gasket separating the working electrode block from the cell body, the gasket defining a sample flow pathway extending between an inlet and an outlet of the detection cell and in fluid contact with the cell body, the counter electrode, and the working electrode; and a reference electrode system in fluidic contact with the outlet and including a platinum auxiliary electrode operably connected to a positive pole of a power supply and a platinum reference electrode operably connected to a negative pole of the power supply.
A pH gradient mobile phase preparation kit is described. The preparation kit includes a first component and a second component. The first component includes a first reagent separate from a second reagent. The first reagent, the second reagent, and a solvent together provide a volatile buffer solution having a low pH. The second component includes a base. The base mixed in the solvent provide a volatile base solution having a high pH. A method of separating and detecting one or more analytes comprised in a matrix of components in a sample, using the kit is also described.
The present invention relates to, in general, a disposable electrically insulating substrate surface comprising a platinum hydrogen reference electrode system structure, the use of such a substrate in a flow-through electrochemical cell assembly and methods of manufacturing said substrate. For example, in some embodiments, a disposable electrically insulating substrate surface comprising a platinum hydrogen reference electrode system structure, wherein the platinum hydrogen reference electrode system comprises an electrically conductive and electrochemically active platinum hydrogen reference electrode system region bound as a layer, directly or indirectly, to said substrate surface.
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes chromatogram logic to calculate the square of a retention time and a peak width variance for each of a plurality of peaks in a chromatogram; plate calculation logic to calculate an expected plate number and an observed plate number; and suppressor status logic to determine a suppressor status based on a ratio of the observed plate number to the expected plate number (O/E ratio) and to display the status.
G01N 30/90 - Plate chromatography, e.g. thin layer or paper chromatography
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes chromatogram logic to calculate the square of a retention time and a peak width variance for each of a plurality of peaks in a chromatogram; plate calculation logic to calculate an expected plate number and an observed plate number; and suppressor status logic to determine a suppressor status based on a ratio of the observed plate number to the expected plate number (O/E ratio) and to display the status.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
An ion exchange device comprises a primary channel member, a first regenerant flow channel member, a second regenerant flow channel member, a first ion exchange membrane, a second ion exchange membrane, and a first electrode and a second electrode. The first and second regenerant flow channels are configured to have consistent flow.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
32.
ELECTROLYTIC ELUENT GENERATORS WITH STABILIZED OPERATING VOLTAGES
An electrolytic eluent generator includes an electrolyte reservoir, an eluent generation chamber, and an ion exchange membrane stack. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution including an electrolyte; and a first electrode. The eluent generation chamber including a second electrode. The ion exchange connector includes an ion exchange membrane stack, and a compression block.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
33.
REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER
An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
34.
SAMPLE PREPARATION SYSTEM AND METHOD FOR EXTRACTING ANALYTE FROM SAMPLE BY MEANS OF SAMPLE PREPARATION SYSTEM
A method of extracting an analyte from a sample by means of a sample preparation system, which comprises the following steps: supplying to sample cells (122a-122d) a gas and a liquid solvent capable of dissolving an analyte in a sample; receiving a liquid solvent containing the analyte from the extraction module, and transferring to evaporation containers (141a-141d); performing evaporation on the liquid solvent containing the analyte in the evaporation containers (141a-141d), an evaporation module being in fluid communication with the sample cells (122a-122d); and allowing the evaporation step to be started after at least a part of the liquid solvent from the extraction module containing the analyte enters the evaporation containers (141a-141d). Extraction and evaporation are integrated together to allow "on-line evaporation/concentration", consequently avoiding an analyte transfer process, thereby reducing labor, increasing processing speed, and avoiding the risk of contamination. Further provided is a sample preparation system for extracting an analyte from a sample.
A suppressor comprising one or more channels, a flow path for each of the channels, and one or more measurement probes positioned in the flow path is described. Each channel includes an inlet and an outlet. Each flow path includes an upstream path to the inlet, a channel stream path through the channel and connecting the inlet to the outlet, and a downstream path from the outlet. A system including the suppressor as well as methods implementing the suppressor are also described.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
36.
System for electrospray ionization with integrated lc column and electrospray emitter
An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
37.
Extraction cell cap assembly with toolless disassembly
An extraction cell cap assembly allows for toolless disassembly. The assembly includes a cap body having a threaded base releasably engaged with a cell vessel, a support member extending axially upward from the base, and a bore axially extending through the support member. The assembly also includes a locking cap having a plunger slidably received within the bore, a recess disposed within the plunger, and a locking portion that releasably engages the support member. Rotation of the locking cap in a first direction engages the locking portion with the support member, and rotation in an opposite direction disengages the locking portion. A filter is received in the recess and a seal member received in the bore, wherein the seal member forms a fluid-tight seal between the cell vessel and the assembly when the locking portion and the support member are engaged and the assembly is secured to the cell vessel.
B01D 29/96 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ; Filtering elements therefor in which the filtering elements are moved between filtering operations; Particular measures for removing or replacing the filtering elements; Transport systems for filters
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
38.
LOW TEMPERATURE OLIGOSACCHARIDE ANALYTICAL SYSTEM AND METHOD
A novel analytical system and method to analyze complex carbohydrates such as human milk oligosaccharides by low-temperature High-Performance Anion Exchange Chromatography with Pulsed Amperometric Detection and High-resolution Mass Spectrometry (HPAE-PAD-MS). The analytical system controls the temperature of the column, electrochemical detector, and ion removal device at or below 15° C. The HPAE-PAD workflow with high-resolution mass spectrometry provides useful molecular structure information. It facilitates the detection of milk oligosaccharides, particularly unknown structures, without the use of analytical standards.
An electrolytic eluent generator includes an electrolyte reservoir and at least one eluent generation cartridge. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution; and a first electrode. The at least one eluent generation cartridge includes a platinum mesh electrode; a polymer screen; a plurality of reinforced membranes; a membrane washer; and a spacer including a central post and an annular projection.
C25B 9/01 - Electrolytic cells characterised by shape or form
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
C25B 13/02 - Diaphragms; Spacing elements characterised by shape or form
C25B 11/042 - Electrodes formed of a single material
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
An analytical system comprises a chromatography column configured to separate a sample into one or more analytes; an ion removal device configured to remove at least ions of one charge from the mobile phase, the ion removal device fluidly coupled to an output of the chromatography column; an ion selective sensor configured to measure a signal corresponding to an activity of the ions of one charge in the mobile phase, the ion selective sensor fluidly coupled to an output of the ion removal device; an optional diverter valve that can interrupt the flow of the mobile phase; and a microprocessor configured to monitor the signal of the ion selective sensor and to either switch the optional diverter valve to interrupt the flow of the mobile phase or turn off the pump when the signal is greater than a predetermined threshold.
An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
44.
Method and system for self-regulating a suppressor
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
The eluent used in IC separation contains non-volatile salt which is not compatible with electrospray ionization-mass spectrometry (ESI-MS). A suppressor is required to convert the non-volatile salt into water or the volatile acid form (i.e. acetic acid). When the suppressor fails, the non-volatile salts will enter the MS and cause extensive shutdown and maintenance of the mass spectrometer. The suppressor voltage derivative is used to evaluate the most common suppressor failure modes, including disruption of regenerant flow and excessive backpressure on the suppressor due to clogging in the downstream, and to trigger the eluent pump to stop the eluent flow or to trigger the auxiliary valve to switch the flow to the mass spectrometer from eluent to water.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
Board of Regents, The University of Texas System (USA)
Dionex Corporation (USA)
Inventor
Dasgupta, Purnendu K.
Chen, Yongjing
Srinivasan, Kannan
Abstract
Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
47.
ELECTROLYTIC ELUENT GENERATORS WITH STABILIZED OPERATING VOLTAGES
An electrolytic eluent generator includes an electrolyte reservoir, an eluent generation chamber, and an ion exchange membrane stack. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution including an electrolyte; and a first electrode. The eluent generation chamber including a second electrode. The ion exchange connector includes an ion exchange membrane stack, and a compression block.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
A system for self-directed computer system validation includes first logic to provide a graphical user interface to enable a user to select a set of selected requirements from a plurality of available requirements; second logic to select a set of procedures to satisfy the need to test against each of the requirements and document evidence of the outcomes and generate a set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system; and third logic to provide the set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system.
A chromatography system includes an electrolytic eluent generator; a first valve configured to switch between an operating position which directs an output of the electrolytic eluent generator to a continuously generated trap column and a waste position which directs the output of the electrolytic eluent generator to waste; the continuously regenerated trap column; a degasser; a sample injector including a sample injector valve assembly, the sample injector valve assembly configured to switch between an operation mode which directs an output of the degasser to a separation column, a load mode which loads a sample onto the separation column, and a regenerant mode which directs the output of the degasser to a regenerant line; the separation column; a suppressor; and a detector.
Ion exchange stationary phases are prepared with diprimary diamines for applications such as separating samples that contain polyvalent anions. The ion exchange stationary phase includes a series of condensation polymer reaction products bound to a substrate. The condensation polymer products are formed with diprimary diamines and polyepoxide compounds. The ion exchange stationary phases described herein are capable of separating monovalent and highly polyvalent anions relatively quickly with relatively low eluent concentrations in one chromatographic run.
B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 41/20 - Anion exchangers for chromatographic processes
B01J 41/05 - Processes using organic exchangers in the strongly basic form
B01J 41/07 - Processes using organic exchangers in the weakly basic form
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
A coated substrate that comprises a polyolefin substrate having a functional polymer layer disposed thereon. The polyolefin substrate has a flow through pore structure with a pore size ranging from about 5 microns to about 250 microns. The functional polymer layer has a thickness ranging from about 1 micron to about 20 microns and a layer pore structure having a pore size ranging from about 1 nm to about 100 nm.
A coated substrate that comprises a polyolefin substrate having a functional polymer layer disposed thereon. The polyolefin substrate has a flow through pore structure with a pore size ranging from about 5 microns to about 250 microns. The functional polymer layer has a thickness ranging from about 1 micron to about 20 microns and a layer pore structure having a pore size ranging from about 1 nm to about 100 nm.
Systems and methods for concentrating an analyte preparatory to analysis thereof include processing the effluent of an analyte concentrator to produce an eluent for eluting an analyte retained in the same or separate concentrator, and systems implementing the same. The analyte concentrator system connects the effluent outlet of an analyte concentrator column to an eluent generation module such that the substantially analyte-free effluent discharged from the analyte concentrator column passes fluidly into the eluent generation module. Eluent generated from the substantially analyte-free effluent in the eluent generation module is likewise substantially free of the analyte. The systems and methods can minimize and/or (substantially) eliminate background signal during analysis of the concentrated analyte.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Dasgupta, Purnendu
Shelor, Charles, P.
Srinivasan, Kannan
Pohl, Christopher, A.
Abstract
An electrochemical cell comprises a chamber, an inlet port, an outlet port, an electrode port, and a counter electrode. The inlet port is configured to allow flow of a liquid into the chamber and through an inlet opening toward the working electrode, and the outlet port is configured to allow flow of a liquid out of the chamber and through an outlet opening. The device is configured so that a force applied to the working electrode slides the first end face of the working electrode to a distance from a face of the inlet opening due to the balancing force of a fluid flowing out of the inlet opening. The device may be used in a method for analyzing an analyte, such as one or more amino acids in a liquid sample.
Board of Regents, The University of Texas System (USA)
Inventor
Dasgupta, Purnendu
Shelor, Charles P.
Srinivasan, Kannan
Pohl, Christopher A.
Abstract
An electrochemical cell comprises a chamber, an inlet port, an outlet port, an electrode port, and a counter electrode. The inlet port is configured to allow flow of a liquid into the chamber and through an inlet opening toward the working electrode, and the outlet port is configured to allow flow of a liquid out of the chamber and through an outlet opening. The device is configured so that a force applied to the working electrode slides the first end face of the working electrode to a distance from a face of the inlet opening due to the balancing force of a fluid flowing out of the inlet opening. The device may be used in a method for analyzing an analyte, such as one or more amino acids in a liquid sample.
A sampling needle is provided for piercing a septum of a vial containing a sample and aspirating the sample from the vial. The needle may include: a tubular core having a lumen extending therethrough and a piercing end, wherein the tubular core is formed of a bioinert material; a hollow support encircling the tubular core with the piercing end extending outwardly from the support, wherein the support is formed of a rigid material; and a bioinert coating covering a portion of the support adjacent the piercing end, wherein the tubular core and the covering isolates the support from the sample.
A method of separating a liquid sample containing viral vectors includes flowing the liquid sample into an anion exchange column. A first viral vector contains a targeted genetic material and a second viral vector contains essentially no genetic material or a non-targeted genetic material, wherein the targeted genetic material is different than the non-targeted genetic material. A mobile phase can be flowed into the anion exchange column, wherein the mobile phase includes a buffer solution A and a buffer solution B. The buffer solutions A and B both include volatile buffer salts. The first viral vector and the second viral vector can be separated so that the first viral vector and the second viral vector elute off the anion exchange column at different times and then be detected.
An ion source and ion recycle module includes an electrolyte reservoir, an eluent recovery chamber, and an ion exchange connector. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution including an electrolyte having a chamber inlet and a chamber outlet, and a first electrode. The chamber inlet is fluidically connected to a source chamber of an electrolytic eluent generator and configured to receive depleted electrolyte solution from the source chamber of the electrolytic eluent generator. The chamber outlet is fluidically connected to the source chamber of the electrolytic eluent generator and configured to provide recycled electrolyte solution to the electrolytic eluent generator source chamber. The eluent recovery chamber including a second electrode and configured to receive an eluent solution including eluent counter ions from the eluent generator; and the ion exchange connector including an ion exchange membrane stack.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
An extraction cell cap assembly allows for toolless disassembly. The assembly includes a cap body having a threaded base releasably engaged with a cell vessel, a support member extending axially upward from the base, and a bore axially extending through the support member. The assembly also includes a locking cap having a plunger slidably received within the bore, a recess disposed within the plunger, and a locking portion that releasably engages the support member. Rotation of the locking cap in a first direction engages the locking portion with the support member, and rotation in an opposite direction disengages the locking portion. A filter is received in the recess and a seal member received in the bore, wherein the seal member forms a fluid-tight seal between the cell vessel and the assembly when the locking portion and the support member are engaged and the assembly is secured to the cell vessel.
B01D 29/96 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ; Filtering elements therefor in which the filtering elements are moved between filtering operations; Particular measures for removing or replacing the filtering elements; Transport systems for filters
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
A carrier for adsorption a compound, comprising a support; and a shrink-fitted monolithic body attached to and surrounding at least a portion of the support. The monolithic body can be porous and configured to bind compounds in a solution either for the isolation or depletion of the compounds from the solution.
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The Board of Regents, The University of Texas System (USA)
Inventor
Kadjo, Akinde F.
Srinivasan, Kannan
Dasgupta, Purnendu K.
Abstract
A method of determining an identity of a first analyte in a sample is described that includes passing the first analyte through a chromatographic column and detecting a signal curve of the first analyte by a chromatographic detector, wherein the signal curve includes a peak profile of the first analyte. The peak profile is defined by a plurality of measured data points configured to plot onto a signal coordinate system. The method further includes normalizing the peak profile of the first analyte to form a normalized peak profile, wherein the normalized peak profile includes scaling the plurality of measured data points, and wherein the normalized peak profile is defined by a plurality of normalized data points configured to plot onto a normalized coordinate system, and comparing the normalized peak profile of the first analyte with a normalized peak profile of a second analyte.
Systems and methods for inhibiting translocation of ions across ion exchange barriers include an eluent generator having an ion source reservoir with a first electrode, an eluent generation chamber with a second electrode, an ion exchange barrier disposed therebetween, and means for reversing the polarity of a voltage or current applied across the first and second electrodes. A first polarity voltage or current applied across the electrodes generates an electric field that promotes translocation of eluent counter ions from the reservoir across the barrier, where the counter ions combine with eluent ions electrolytically generated in the chamber. By reversing the polarity of the voltage or current across the electrodes, the resulting electric field inhibits translocation of counter ions across the barrier from the reservoir into the chamber. Reverse voltage or current bias reduces counter ion concentration in the resting chamber to prevent exhaustion of ion suppressor capacity during start up.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
G01N 30/28 - Control of physical parameters of the fluid carrier
An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
An ion exchange resin for use as a stationary phase in an ion chromatography column. The ion exchange resin has a negatively charged substrate particle, a positively charged polymer layer bound to the negatively charged substrate particle, a linker, and an ion exchange group. The ion exchange group includes a sulfonamide group and an amine, in which the ion exchange group is coupled to the positively charged polymer layer via the linker. When the sulfonamide is in a neutral form, a positively charged amine group provides retention: while when the sulfonamide is in an anionic form, the sulfonamide anion becomes a counter ion to the positively charged amine group, forming a zwitterion that reduces retention at that site. Accordingly, the retention time is able to be controlled by adjusting the mobile phase pH.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
B01J 41/20 - Anion exchangers for chromatographic processes
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 41/05 - Processes using organic exchangers in the strongly basic form
A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
C07H 15/23 - Cyclohexane rings, substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
C07H 15/232 - Cyclohexane rings, substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
C07H 15/234 - Cyclohexane rings, substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
C07H 15/238 - Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
C07H 15/224 - Cyclohexane rings, substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexane rings, e.g. destomycin, fortimicin, neamine
C08G 77/392 - Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing sulfur
69.
Anion exchange stationary phases based on a polyalkylpolyamine polymer layer
An anion exchange for separating a plurality of carbohydrates includes a negatively charged substrate particle. A base polymer layer includes a first plurality of quaternary amines. The polyalkylpolyamine polymer layer is covalently attached to the base condensation polymer layer. The polyalkylpolyamine polymer layer includes a polymeric branch structure that includes a second plurality of quaternary amines. A density of the second plurality of quaternary amines increases in a direction away from the base condensation polymer layer. The anion exchange stationary phase does not have a hydroxy group spaced apart from any one of the first or the second plurality of quaternary amines by an ethyl group.
B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
70.
Vial cap and method for removing matrix components from a liquid sample
A vial cap for removing a matrix component from a liquid sample is described. The vial cap includes a cap body, an inlet portion, and an outlet portion. The cap body is configured to have a slidable gas and liquid seal with a side wall of a sample vial. The inlet portion includes a counterbore section that holds a filter plug. The filter plug includes a polyethylene resin and a material selected from the group consisting of an ion exchange material and a reversed-phase material. The vial cap is adapted for solid phase extraction for use in an autosampler with a plurality of sample vials.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
G01N 30/14 - Preparation by elimination of some components
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
An ion exchange chromatography column contains an ion exchange stationary phase that includes a charged substrate, a plurality of first particles, and a plurality of second particles. The plurality of first particles each include first ion exchange groups and the first particles are ionically bound to the charged substrate. The plurality of second particles each include second ion exchange groups and the second particles are ionically bound to the charged substrate. The first particles having a first ion exchange group density, and the second particles having a second ion exchange group density. The first ion exchange group density is greater than the second ion exchange group density. The ion exchange chromatography column has a number of zones connected in series where each zone can have a varying level of first ion exchange groups and second ion exchange group from the inlet zone to the outlet zone.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J 41/05 - Processes using organic exchangers in the strongly basic form
B01J 41/07 - Processes using organic exchangers in the weakly basic form
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 41/20 - Anion exchangers for chromatographic processes
B01J 47/022 - Column or bed processes characterised by the construction of the column or container
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
72.
Functionalized polyolefin capillaries for open tubular ion chromatography
Board of Regents, University of Texas System (USA)
Dionex Corporation (USA)
Inventor
Dasgupta, Purnendu K.
Huang, Weixiong
Pohl, Christopher A.
Abstract
3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
A plurality of chromatograms is run using a salt gradient with a range of constant pH values or using a pH gradient with a range of constant salt concentrations. A chromatography optimization algorithm can be used to identify at least one salt gradient chromatogram or at least one pH gradient chromatogram to establish optimized buffer conditions. The chromatography optimization algorithm can include a total number of peaks algorithm, a peak-to-valley algorithm, and/or a peak capacity algorithm.
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
An ion exchange chromatographic packing material is described that includes support resin particles and a copolymer grafted to the support resin particles. The copolymer includes polymerized functional monomers such as a first ion exchange group monomer and a second ion exchange group monomer. At a first pH, the first ion exchange group monomer is configured to have a first charge at a first pH, and the second ion exchange group monomer is configured to have a net neutral charge. At a second pH, the first ion exchange group monomer is configured to have the first charge at a second pH, and the second ion exchange group monomer is configured to have a second charge at the second pH where the first charge and second charge both have a same polarity.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 39/26 - Cation exchangers for chromatographic processes
B01J 41/20 - Anion exchangers for chromatographic processes
B01J 39/05 - Processes using organic exchangers in the strongly acidic form
B01J 39/07 - Processes using organic exchangers in the weakly acidic form
B01J 41/07 - Processes using organic exchangers in the weakly basic form
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
A suppressor for use in reducing a background signal while detecting analytes in a liquid sample for ion chromatography is described. The suppressor includes a central channel and two flanking regenerant channels. The central channel is formed with an eluent channel plate including a central cutout portion having a peripheral boundary portion. The peripheral boundary portion includes a recessed eluent plate height that is less than the eluent plate height. The peripheral boundary portion includes two or more notches or protrusions. An eluent screen is disposed in the central cutout portion, in which a peripheral border of the eluent screen has two or more corresponding notches or corresponding protrusions to the eluent channel plate.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
09 - Scientific and electric apparatus and instruments
Goods & Services
Electronic laboratory and scientific equipment, namely, flow
sensors, pressure sensors, and temperature sensors, to
measure precisely the flow of fluids in liquid
chromatographs; laboratory and scientific equipment, namely,
control devices used in pump modules to regulate the flow of
fluids in liquid chromatographs.
A vial cap for removing a matrix component from a liquid sample is described. The vial cap includes a cap body, an inlet portion, and an outlet portion. The cap body is configured to have a slidable gas and liquid seal with a side wall of a sample vial. The inlet portion includes a counterbore section that holds a filter plug. The filter plug includes a polyethylene resin and a material selected from the group consisting of an ion exchange material and a reversed-phase material. The vial cap is adapted for solid phase extraction for use in an autosampler with a plurality of sample vials.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
G01N 30/14 - Preparation by elimination of some components
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
An anion exchange stationary phase includes a negatively charged substrate particle, a base condensation polymer layer, a crosslinked ethanolamine condensation polymer, and a glycidol condensation layer. The crosslinked ethanolamine condensation polymer layer can be covalently attached to the base condensation polymer layer. The crosslinked ethanolamine condensation polymer layer can be formed by a condensation reaction product of a polyepoxide compound and ethanolamine. The glycidol condensation layer can be formed by the treatment of glycidol. The anion exchange stationary phase are suitable for separating a variety of haloacetic acids and common inorganic anions in a single chromatographic run in less than 20 to 35 minutes.
A chromatographic media for separating bio-polymers, the chromatographic media having cationic exchange properties and anionic exchange properties, the chromatographic media comprising: (a) non-porous substrate particles including an organic polymer, the substrate particles having a neutral hydrophilic layer at a surface of the non-porous substrate particles, in which the neutral hydrophilic layer is configured to reduce a binding of the bio-polymers directly to the non-porous substrate particles compared to a binding of the bio-polymer to the non-porous substrate particles without the neutral hydrophilic layer; (b) a charged first ion exchange layer bound to the substrate particles on top of the hydrophilic layer, the first ion exchange layer comprising first ion exchange groups; and (c) a charged second ion exchange layer bound to the substrate particles on top of the first ion exchange layer.
B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device. A volatile component in the liquid solution is transported across a first ion exchange barrier from the first chamber to a second chamber. The first ion exchange barrier has a first charge. The second chamber includes an ion exchange packing having a second charge that is an opposite polarity to the first charge. The volatile component reacts with the ion exchange packing to create a charged component in the second chamber. The charged component having a third charge that is a same polarity to the first charge. The ion exchange packing is regenerated by electrolytically generating a hydronium or a hydroxide.
C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01D 15/24 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
85.
Anion exchange stationary phases based on crosslinked hydroxyalkylamine layer and glycidol
An anion exchange stationary phase includes a negatively charged substrate particle, a base condensation polymer layer, a crosslinked ethanolamine condensation polymer, and a glycidol condensation layer. The crosslinked ethanolamine condensation polymer layer can be covalently attached to the base condensation polymer layer. The crosslinked ethanolamine condensation polymer layer can be formed by a condensation reaction product of a polyepoxide compound and ethanolamine. The glycidol condensation layer can be formed by the treatment of glycidol. The anion exchange stationary phase are suitable for separating a variety of haloacetic acids and common inorganic anions in a single chromatographic run in less than 20 to 30 minutes.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
A carrier for adsorption a compound, comprising a support; and a shrink-fitted monolithic body attached to and surrounding at least a portion of the support. The monolithic body can be porous and configured to bind compounds in a solution either for the isolation or depletion of the compounds from the solution.
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A carrier for adsorption a compound, comprising a support; and a shrink-fitted monolithic body attached to and surrounding at least a portion of the support. The monolithic body can be porous and configured to bind compounds in a solution either for the isolation or depletion of the compounds from the solution.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
88.
Ion exchange stationary phases for analyzing polyvalent ions
Ion exchange stationary phases are prepared with diprimary diamines for applications such as separating samples that contain polyvalent anions. The ion exchange stationary phase includes a series of condensation polymer reaction products bound to a substrate. The condensation polymer products are formed with diprimary diamines and polyepoxide compounds. The ion exchange stationary phases described herein are capable of separating monovalent and highly polyvalent anions relatively quickly with relatively low eluent concentrations in one chromatographic run.
B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 41/20 - Anion exchangers for chromatographic processes
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
B01J 41/05 - Processes using organic exchangers in the strongly basic form
B01J 41/07 - Processes using organic exchangers in the weakly basic form
89.
Fast startup ion chromatography system and methods
Systems and methods for inhibiting translocation of ions across ion exchange barriers include an eluent generator having an ion source reservoir with a first electrode, an eluent generation chamber with a second electrode, an ion exchange barrier disposed therebetween, and means for reversing the polarity of a voltage or current applied across the first and second electrodes. A first polarity voltage or current applied across the electrodes generates an electric field that promotes translocation of eluent counter ions from the reservoir across the barrier, where the counter ions combine with eluent ions electrolytically generated in the chamber. By reversing the polarity of the voltage or current across the electrodes, the resulting electric field inhibits translocation of counter ions across the barrier from the reservoir into the chamber. Reverse voltage or current bias reduces counter ion concentration in the resting chamber to prevent exhaustion of ion suppressor capacity during start up.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
G01N 30/28 - Control of physical parameters of the fluid carrier
90.
Nanometer size chemical modified materials and uses
A method of separating analytes in a liquid sample includes flowing the liquid sample through a chromatography column configured for use in liquid chromatography. The chromatography column contains a composition that includes a solid support having an exterior surface, a ligand, and a linker. The ligand includes a polyhedral oligomeric silsesquioxane moiety. The linker is covalently bound to both the polyhedral oligomeric silsesquioxane moiety and the exterior surface of the solid support.
An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B29K 71/00 - Use of polyethers as moulding material
Board of Regents, The University of Texas System (USA)
Dionex Corporation (USA)
Inventor
Dasgupta, Purnendu K.
Chen, Yongjing
Srinivasan, Kannan
Abstract
Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
95.
Flow control in an electrolytic reagent concentrator for ion chromatography
An in-line electrolytic reagent concentrator device that circumvents the need for additional pumps and supplies of reagents to support operation of a carbonate or ammonia removal device. The device generates regenerant solutions as strong as, or even stronger, than commercially recommended regenerant solutions. The device may also regenerate eluent solutions so as to reduce the frequency of eluent maintenance and replacement in ion chromatography systems.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
B01J 47/12 - Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
99.
MULTIMODAL CHROMATOGRAPHIC MEDIA FOR PROTEIN SEPARATION
A chromatographic media for separating bio-polymers, the chromatographic media having cationic exchange properties and anionic exchange properties, the chromatographic media comprising: (a) non-porous substrate particles including an organic polymer, the substrate particles having a neutral hydrophilic layer at a surface of the non-porous substrate particles, in which the neutral hydrophilic layer is configured to reduce a binding of the bio-polymers directly to the non-porous substrate particles compared to a binding of the bio-polymer to the non-porous substrate particles without the neutral hydrophilic layer; (b) a charged first ion exchange layer bound to the substrate particles on top of the hydrophilic layer, the first ion exchange layer comprising first ion exchange groups; and (c) a charged second ion exchange layer bound to the substrate particles on top of the first ion exchange layer.
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
An analyte concentration can be measured at an electrochemical detector using a waveform that includes a reductive voltage. The waveform may include three or four different voltages, in which at least one of the voltage values is reductive. One or more current or charge values can be measured during at least part of a reductive voltage portion of the waveform. The analyte concentration can be calculated based on the measured one or more current or charge values.
B01D 15/08 - Selective adsorption, e.g. chromatography
G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
