The present invention relates to a method performed in a liquid chromatography system, the method comprising: in a first configuration (I), wherein a first separation column is fluidly connected to a separation pump and a detector, supplying a flow from the first separation column towards the detector by means of the separation pump in the first configuration (I); and switching the liquid chromatography system from the first configuration (I) to a second configuration (II), wherein the first separation column is fluidly connected to a second pump and to the detector, and supplying a flow from the first separation column towards the detector by means of the second pump in the second configuration (II). The present invention also relates to a corresponding system, use, computer program product, computer-readable medium and data carrier signal.
The present invention relates to a method in a liquid chromatography system comprising a first separation column, a second separation column, a separation pump upstream the separation columns and a detector downstream the separation columns, the method comprising: detecting a failover activation event relating to one of the separation columns, said separation column being a non-operational column, while the other an operational column; operating the liquid chromatography system in a failover operation mode, after detecting the failover activation event. Operating the liquid chromatography system in the failover operation mode comprises: allowing a fluid connection between the separation pump, the operational column and the detector and preventing a fluid connection between the non-operational column and the detector. The present invention also relates to a system for liquid chromatography.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
The present invention relates to a method to validate at least one chromatographic procedure, wherein the method comprises: a data processing device validating a plurality of parameters relating to the at least one chromatographic procedure, wherein the validating comprises the data processing device checking whether at least one boundary condition is met. The present invention also relates to a corresponding system, computer program, computer-readable medium and data carrier signal.
Systems or techniques are provided for remote connection and operation of scientific instruments are provided. In various embodiments, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a modeling component that generates a digital representation of a scientific instrument, wherein the digital representation of the scientific instrument comprises: a discovery subcomponent that generates a communication beacon for the scientific instrument, wherein the communication beacon enables automatic discovery and connection of a remote device to the scientific instrument across a network.
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
The present invention relates to a needle assembly comprising a needle, a needle housing, wherein the needle housing comprises at least one aligning component. The present invention also relates to a needle receiving assembly comprising a fluid conducting element and a fluid conducting element housing, wherein the fluid conducting element housing comprises at least one aligning component. Additionally, the present invention relates to connection assemblies, samplers and systems that can comprise the needle assembly and the needle receiving assembly.
A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
G01M 3/26 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
The present invention relates to a method for setting up a workflow for a chromatography system, wherein the workflow comprises a plurality of workflow parameters, the method comprising providing subroutines of the workflow; providing at least one boundary condition for at least one workflow parameter; assigning a duration and a start time to each of the subroutines; and generating the workflow by combining the subroutines. Furthermore, the present invention relates to a chromatography system and a computer program product.
The present disclosure relates to a measuring tube for a Coriolis flow meter, comprising a looped tube section, and two connecting tube sections, wherein a first end of each of the two connecting tube sections is respectively fluidly connected to a different end of the looped tube section. Further, each of the connecting tube sections comprises a first portion and a second portion, wherein the looped tube section defines a first plane, wherein the second portion of each connecting tube section extends out of the first plane in a first direction, and wherein the first portion of each connecting tube section extends out of the first plane in a direction opposite to the first direction. Additionally the present disclosure relates to a Coriolis flow meter comprising a respective measuring tube.
The present disclosure relates to an excitation device for exciting an oscillation, comprising a fixable portion, a movable portion configured to move with respect to the fixable portion, a connection portion, wherein the movable portion is connected to the fixable portion via the connection portion, a piezo element fixedly mounted to the fixable portion, and a connecting element mechanically connecting the piezo element and the movable portion. Furthermore, a Coriolis flow meter comprising a measuring tube, at least one sensor configured to detect motion of the measuring tube, and an excitation device configured to excite an oscillation of the measuring tube is disclosed.
The present invention relates to the field of chromatographic sample separation that includes liquid chromatography and solid phase extraction and, in particular, it relates to material and the synthesis of material for use as a stationary phase in chromatographic sample separation. The invention further relates to uses of the material, in particular in the separation of hydrophilic and hydrophobic peptides, non-glycosylated and N-linked glycosylated peptides, deamidated and oxidized peptides. The invention also relates to chromatographic columns and solid phase extraction columns containing the material as a stationary phase.
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present invention relates to the field of chromatographic sample separation that includes liquid chromatography and solid phase extraction and, in particular, it relates to material and the synthesis of material for use as a stationary phase in chromatographic sample separation. The invention further relates to uses of the material, in particular in the separation of hydrophilic and hydrophobic peptides, non-glycosylated and N-linked glycosylated peptides, deamidated and oxidized peptides. The invention also relates to chromatographic columns and solid phase extraction columns containing the material as a stationary phase.
A method for operating a chromatography system comprises the system assuming a first configuration, wherein a first pump is fluidly connected to a first separation column, and a second pump is fluidly connected to a second separation column. Further the method comprises while in the first configuration the first pump providing a fluid to the first separation column, the second pump providing a fluid to the second separation column, determining a second pump target pressure, determining a first pump target pressure based on the second pump target pressure, and setting the first pump to provide fluid at the first pump target pressure. Furthermore, the method comprises the system switching to a second configuration, wherein the first pump is fluidly connected to the second separation column, while the first pump provides fluid at the first pump target pressure. Additionally disclosed are a respective chromatography system and computer program product.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
A method comprising a first pump unit delivering a first flow of a first solvent at a first flow rate, and a second pump unit delivering a second flow of a second solvent at a second flow rate. At a first process stage of the first run when the first flow rate exceeds the second flow rate, the first pump unit assuming a first pump unit state, in the second run, at a first process stage of the second run, setting the first pump unit to the first pump unit state. At a second process stage of the first run when the second flow rate exceeds the first flow rate, the second pump unit assuming a second pump unit state, and in the second run, at a second process stage of the second run, setting the second pump unit to the second pump unit state.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes a first logic to obtain chromatographic data sets from a chromatographic system; a second logic to perform a first analysis of the one or more chromatographic data sets to generate a first result perform a second analysis of the one or more chromatographic data sets to generate a second result; and a third logic to identify differences between the first result and the second result; provide a user interface configured to indicate the data sets where the second result differs from the first result; and display one or more chromatograms representative of the indicated data sets and visually identifying features on the chromatograms where the differences occur.
A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.
A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes a first logic to obtain chromatographic data sets from a chromatographic system; a second logic to perform a first analysis of the one or more chromatographic data sets to generate a first result perform a second analysis of the one or more chromatographic data sets to generate a second result; and a third logic to identify differences between the first result and the second result; provide a user interface configured to indicate the data sets where the second result differs from the first result; and display one or more chromatograms representative of the indicated data sets and visually identifying features on the chromatograms where the differences occur.
Systems and methods under the present disclosure can provide communication between instruments or resources at multiple locations. One example is a system of interconnection for various types of assets at multiple laboratories in different locations. Assets, devices, resources, or services at a location can multicast a beacon identifying itself. Verification of the asset, etc., can be done by communicating with a URI associated with that asset. Authentication of assets can be token-based to enable communication. Proxy servers at all or some of the locations can manage authentication and communication between locations and between assets. Tunnels can be implemented between different locations to help ensure secure communication.
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
The present invention relates to a rotor for a rotary shear valve, the rotor comprising a rotor sealing surface and a compensating element, as well as to a rotor assembly for a rotary shear valve, the rotor assembly comprising a rotor according to any of the preceding rotor embodiments and a rotor receptacle configured to receive the rotor, wherein the rotor is connected to the rotor receptacle in a rotationally fixed manner. Furthermore, the present invention also relates to a rotary shear valve comprising a rotor comprising a compensating element, a rotor receptacle configured to receive the rotor, a stator and a drive unit.
A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.
A method of washing an element in a chromatography system, wherein the method includes performing an element rinse step. The element rinse step includes providing a first washing liquid with a first composition towards the element, and providing a second washing liquid with a second composition towards the element, wherein the second composition is different from the first composition.
Disclosed herein are chromatography support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, the systems and methods disclosed herein may enable the automatic identification of error or fault conditions in a chromatography system.
Disclosed herein are chromatography support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, the systems and methods disclosed herein may enable the automatic identification of error or fault conditions in a chromatography system.
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
The present invention relates to a method of loading a fluid into a fluidic element, wherein the method is performed in a fluidic system comprising the fluidic element, wherein the method comprises determining a volume that has flown into the fluidic element since a start time tstart, and at a switching time tswitch, switching the fluidic system to an operating state to stop flow into the fluidic element. The present invention also relates to a fluidic system configured for performing the method, and to a corresponding computer program product.
A plug unit configured for use in high performance liquid chromatography is described. The plug unit comprises a capillary comprising a capillary distal face; a sealing element, wherein at least a portion of the sealing element is located distal from the capillary distal face; and a biasing element configured to bias the capillary towards the sealing element.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
G01M 3/26 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.
The present invention relates to a mixing assembly for mixing a fluid, wherein the mixing assembly comprises a fluid accommodation portion configured to accommodate the fluid, and a wave source, wherein the wave source is configured to generate an acoustic wave. The mixing assembly is configured to inject at least part of the acoustic wave into the fluid accommodated in the fluid accommodation portion to thereby cause mixing of the fluid in the fluid accommodation portion. The present invention also relates to a corresponding liquid chromatography system, method and use.
The present invention relates to a needle (1), wherein the needle (1) comprises a channel (12) extending through the needle (1), wherein the needle (1) comprises a needle tip (11), wherein the channel (12) comprises an opening at the needle tip (11), wherein the needle (1) defines an axial direction (x), wherein the axial direction (x) defines a distal direction and a proximal direction, wherein the needle tip (11) is a distal portion of the needle (1), and wherein the needle tip (11) comprises a first surface section (112) and a second surface section (111), wherein the first surface section (112) is arranged at a first angle (α) with respect to the axial direction (x) and the second surface section (111) is arranged at a second angle (β) with respect to the axial direction (x), wherein the first angle is different from the second angle. The present invention also relates to a corresponding apparatus, system and use.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
The present invention relates to an assembly comprising a source of electromagnetic radiation, a detector assembly comprising a detector for electromagnetic radiation, a tube assembly comprising a portion of a tube, and a source optical element configured to transmit electromagnetic radiation received at a receiving end to an emitting end of the source optical element. The detector assembly comprises a detector assembly receiving end positioned to receive at least a part of the electromagnetic radiation from the source, wherein at least part of the electromagnetic radiation received at the detector assembly receiving end is received by the detector. A first direction (x) is defined by a light path between the emitting end of the source optical element and the detector assembly receiving end, wherein the tube assembly is positioned between the emitting end and the detector assembly receiving end in the first direction (x), wherein the tube assembly is movable to change its position, and wherein an amount of electromagnetic radiation received by the detector depends on the position of the tube assembly. The present invention further relates to a Coriolis flow meter system, a corresponding method and a solvent delivery system.
end, switching the system to a third operating state to bring the pressure in the fluidic resistive element to a third pressure value, the third pressure value being below the second pressure value. The present invention also relates to a corresponding system and a corresponding computer program product.
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes a first logic to obtain chromatography data from chromatography system; and log events of a chromatographic system including changes to instrument methods, processing methods and manual peak integration; a second logic to analyze the chromatography data; and log events of the data analysis and changes to data analysis methods; and a third logic to identify linked events in the audit logs; and providing a user interface for viewing the linked events.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes a first logic to obtain chromatographic data sets from a chromatographic system; a second logic to perform a first analysis of the one or more chromatographic data sets to generate a first result perform a second analysis of the one or more chromatographic data sets to generate a second result; and a third logic to identify differences between the first result and the second result; provide a user interface configured to indicate the data sets where the second result differs from the first result; and display one or more chromatograms representative of the indicated data sets and visually identifying features on the chromatograms where the differences occur.
A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.
The present invention relates to a valve assembly, comprising a valve chamber, accesses to the valve chamber, the accesses including a first access and a second access, and a movable sealing body assembly comprising at least one sealing portion, wherein at least a portion of the sealing body assembly is magnetic, and wherein at least a portion of the sealing body assembly comprising the at least one sealing portion is located within the valve chamber. Further, the valve assembly comprises at least one sealing surface, wherein each of the at least one sealing surface is configured to complement one of the at least one sealing portion, and wherein each sealing surface comprises an orifice fluidly connected to one of the accesses. The valve assembly further comprises a force unit configured to exert a magnetic force on the magnetic portion of the movable sealing body assembly and is configured to assume at least two configurations, wherein in a first configuration, the first access is sealed, and wherein in a second configuration, the first access is fluidly connected to the second access. Further, the present invention relates to a pump system, as well as a use and manufacturing method of a valve assembly according got the present invention.
The present invention relates to a method for monitoring, wherein the sample injector comprises a sample storage portion and a volume displacement device. The method comprises obtaining a pressure characteristic indicative for a pressure of the sample storage portion. In addition, the method comprises obtaining a displacement characteristic indicative for a displacement volume of the volume displacement device, when the volume displacement device is fluidically connected to the sample storage portion. Based on the obtained pressure characteristic and the obtained measured displacement characteristic the method comprises determining at least one result. In addition, the present invention relates to a sample injector, sample injector system and a system configured to carry out the method.
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
G01M 3/26 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
G01N 30/22 - Injection in high pressure liquid systems
41.
System and method for component interconnection in HPLC
A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
In a first aspect, the present invention relates to a method of testing a fluidic system. The method comprising applying a fluid with an input fluidic characteristic to the fluidic system, while the fluidic system is in a first configuration, and measuring an output fluidic characteristic. The method also comprises comparing the measured output fluidic characteristic to a reference. In a further aspect the present invention relates to a testing system configured for testing a fluidic system.
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
A plug for connecting capillaries includes at least one capillary tube, at least one sealing, and at least one pressure piece. The capillary tube includes a first inner diameter and an open end section. The sealing includes a second inner diameter, a first end section and a shape adapted to seal the open end section of the capillary tube when connected. The pressure piece is adapted to exert at least axial pressure and/or force to at least a part of the sealing. The pressure piece is also adapted to host the first end section of the sealing in abutment with the open end section of the capillary tube so that the capillary tube and the sealing are aligned.
A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.
A needle receiving assembly includes a fluid conducting element housing, a sealing element configured to receive a needle, and a fluid conducting element. The needle receiving assembly is configured to connect to a needle of a needle assembly. The fluid conducting element housing comprises an aligning component configured to contact a needle housing of the needle assembly and to increase alignment between the needle and the needle receiving assembly. The fluid conducting element housing comprises a lateral protruding portion including an inner lateral surface that laterally surrounds a cavity of the fluid conducting element housing and a central protruding portion protruding beyond a base of the fluid conducting element housing and the central protruding portion. The aligning component comprises an aligning inner surface formed by a portion of the inner lateral surface of the lateral protruding portion.
A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.
A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.
G01M 3/26 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.
A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.
A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.
A detector system includes a droplet generator system, wherein the droplet generator system includes a droplet generator unit. The droplet generator unit is configured to create droplets from a liquid supplied to the droplet generator unit with a droplet generator liquid flow. The droplet generator unit is configured to create the droplets with a defined droplet generation frequency.
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.
The present invention relates to a method comprising using an acoustic wave in a chromatography system. The present invention also relates to a corresponding system and a corresponding use. The system may comprise a surface acoustic wave assembly, wherein the surface acoustic wave assembly comprises a sender unit comprising a sender transducer for sending an acoustic wave and a detection unit for detecting the acoustic wave, a substrate configured for propagation of the acoustic wave, wherein the sender transducer is connected to the substrate, wherein the substrate comprises a substrate section for propagation of the wave from the sender transducer, wherein this substrate section comprises a substrate surface, wherein the surface acoustic wave assembly further comprises at least one channel for conducting fluid, wherein this channel is partly defined by the substrate surface.
A plug unit configured for use in high performance liquid chromatography is described. The plug unit comprises a capillary comprising a capillary distal face; a sealing element, wherein at least a portion of the sealing element is located distal from the capillary distal face; and a biasing element configured to bias the capillary towards the sealing element.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
A method for measuring a flow of a fluid in a tube includes heating the fluid in the tube with a heating element. A first signal is measured with a first temperature sensing element at a first location. A second signal is measured with a second temperature sensing element at a second location. At least one temperature signal is calculated based on the first signal and the second signal. The at least one temperature signal includes a difference temperature signal and a sum temperature signal. The difference temperature signal is calculated based on a difference between the second signal and the first signal. The sum temperature signal is calculated based on a sum of the second signal and the first signal. The flow is derived based on the difference temperature signal, the sum temperature signal, or a combination thereof.
G01F 1/696 - Circuits therefor, e.g. constant-current flow meters
G01F 25/00 - Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
G01F 1/684 - Structural arrangementsMounting of elements, e.g. in relation to fluid flow
G01F 1/688 - Structural arrangementsMounting of elements, e.g. in relation to fluid flow using a particular type of heating, cooling or sensing element
G01F 1/69 - Structural arrangementsMounting of elements, e.g. in relation to fluid flow using a particular type of heating, cooling or sensing element of resistive type
G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
G01N 30/36 - Control of physical parameters of the fluid carrier in high pressure liquid systems
cor·ƒ(t); and wherein the corrective amplitude Acor is set based on a measure for the flow and a measure for the pressure. The present invention also relates to a corresponding use, a pump, a pump system and an HPLC system.
F04B 49/20 - Control of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for in, or of interest apart from, groups by changing the driving speed
G05D 7/06 - Control of flow characterised by the use of electric means
G01N 30/36 - Control of physical parameters of the fluid carrier in high pressure liquid systems
09 - Scientific and electric apparatus and instruments
Goods & Services
Fittings and connections for use in the field of high
performance liquid chromatography, namely, fittings and
connections for chromatography apparatuses for laboratory
use.
09 - Scientific and electric apparatus and instruments
Goods & Services
Fittings and connections for use in the field of high
performance liquid chromatography, namely, fittings and
connections for chromatography apparatuses for laboratory
use.
62.
Sample pre-compression valve for liquid chromatography
A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
65.
Base to switch an apparatus between slidable and non-slidable states
An apparatus includes a base to switch the apparatus between slidable and non-slidable states, for example a laboratory analysis device, wherein the base is adapted to be located on a flat surface, the base comprising a bottom section adapted to contact the flat surface when the base is located on the flat surface, a movable section that is adapted to assume a retracted position and an extended position, wherein, in the retracted position, the movable section does not contact the flat surface when the base is located on the flat surface, and, in the extended position, the movable section contacts the flat surface when the base is located on the flat surface.
F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
B23Q 1/00 - Members which are comprised in the general build-up of a form of machine, particularly relatively large fixed members
F16M 7/00 - Details of attaching or adjusting engine beds, frames, or supporting-legs on foundation or baseAttaching non-moving engine parts, e.g. cylinder blocks
F16M 9/00 - Special layout of foundations with respect to machinery to be supported
A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.
A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.
A method performed in a liquid chromatography system that includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device (100), wherein the system (1000) is adapted to assume a configuration allowing the metering device (100) to push a sample into the trap column (6) and wherein the metering device (100) is adapted to push the sample into the trap column (6) in this configuration, wherein the system (1000) is adapted to assume a configuration allowing the sample to be sucked into the system (1000) by means of the metering device (100). Furthermore, the invention relates to a use of the liquid chromatography system (1000) for liquid chromatography, in particular of high pressure liquid chromatography.
A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
09 - Scientific and electric apparatus and instruments
Goods & Services
Fittings and connections for use in the field of high performance liquid chromatography, namely, fittings and connections for chromatography apparatuses for laboratory use
A socket unit for a capillary connection system, especially for use in HPLC applications, includes a housing with a housing outer surface and a housing inner surface that define a housing axial cavity. The socket unit also includes a socket connecting mechanism adapted to engage with a corresponding plug connecting mechanism of a plug unit to connect the plug unit and the socket unit together, wherein the socket connecting mechanism is adapted for a predetermined number of discrete connection states between the socket unit and the plug unit.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16L 19/00 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts
F16L 21/02 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings
F16L 21/04 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings in which sealing rings are compressed by axially-movable members
A high-pressure switching valve includes a stator and a rotor. The stator includes a plurality of ports where each port is connected at one end to a port connection and having at another end a predetermined port opening cross section at a stator end face of the stator. The rotor includes a rotor end face and at least one or a plurality of grooves. The rotor can be configured to have a rotary position with respect to the stator where two predetermined port opening cross sections connect to one of the grooves in a pressure-tight manner. The rotor and the stator can be pressed together in a sealing manner at the rotor end face and the stator end face in regions away from the port opening cross sections and the at least one or a plurality of grooves. The rotor and the stator each include a hard material. The rotor can be configured to wobble or tilt with respect to a rotational axis of the rotor.
F16K 11/076 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with sealing faces shaped as surfaces of solids of revolution
G01N 30/22 - Injection in high pressure liquid systems
73.
Methods for injecting samples in liquid chromatography, particularly in high performance liquid chromatography
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.
A plug for connecting capillaries includes at least one capillary tube, at least one sealing, and at least one pressure piece. The capillary tube includes a first inner diameter and an open end section. The sealing includes a second inner diameter, a first end section and a shape adapted to seal the open end section of the capillary tube when connected. The pressure piece is adapted to exert at least axial pressure and/or force to at least a part of the sealing. The pressure piece is also adapted to host the first end section of the sealing in abutment with the open end section of the capillary tube so that the capillary tube and the sealing are aligned.
A process for transferring a method from a starting system to a target system in liquid chromatography, in particular in high performance liquid chromatography, is described. A first chromatogram of the method carried out on the starting system is available or determined. The method developed for the starting system is carried out on the target system without any change in its physical parameters, and a second chromatogram is thereby determined. The two chromatograms of the starting system and the target system are compared, and measures for adjusting the physical system parameters of the target system are derived from the deviations.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.
A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.
A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.
The invention relates to a seal for high pressure applications, in which a static and a dynamic sealing portion are separated from each other by a material thin point in such a manner that plastic flowing through the thin point is suppressed even if one of the two sealing portions is acted upon under high pressure as far as elastic compression.
F04B 53/16 - CasingsCylindersCylinder liners or headsFluid connections
F16J 15/3276 - Mounting of sealing rings with additional static sealing between the sealing, or its casing or support, and the surface on which it is mounted
A sample-taking unit having a sampling unit and a hold-down device which is movable relative thereto in a parallel manner, said sample-taking unit including a self-holding mechanism which, as a result of a self-locking effect, automatically fixes the hold-down device in a lowered fixing position against an upward movement until the self-locking effect is removed again as a result of the self-holding mechanism being acted upon with a detaching force, preferably as a result of contact between the sampling unit and a clamping element of the self-holding mechanism.
A plug unit and system for connecting capillary tubes, especially for high-performance liquid chromatography, with a plug capillary tube projecting through a hole of a plug housing, which is detachably connectable to a bushing unit. The plug capillary tube front end projects into a capillary tube receptacle in the bushing unit with its end face essentially aligned opposite a front end of a bushing capillary tube or a bushing capillary tube opening of the bushing unit, the end face of which is butted against. The plug housing applies a force, with its end face facing the plug capillary tube end, directly or indirectly on an annular sealing element surrounding the plug capillary tube in the region of the front end of the plug capillary tube such that the front end of the plug capillary tube is sealed through deformation of the sealing element against the capillary tube receptacle opening.
F16L 19/06 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts in which radial clamping is obtained by wedging action on non-deformed pipe ends
F16L 21/04 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings in which sealing rings are compressed by axially-movable members
F16L 21/035 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings placed around the spigot end before connection
F16L 19/00 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts
A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
86.
Method for feeding a sample into an analysis branch of a liquid chromatography system
The invention relates to a method for feeding a sample into an analysis branch of a liquid chromatography system, in particular a high-performance liquid chromatography system. A solvent or a solvent mixture from at least one solvent branch is supplied as volume flow {dot over (A)} into the analysis branch. At least one sample from at least one sample branch is fed as volume flow Ė into the analysis branch within a predetermined time interval. The volume flow {dot over (A)} is reduced to an extent during the predetermined time interval, and a volume flow Ċ resulting from the sum of the volume flows {dot over (A)} and Ė remains substantially constant in the analysis branch. The invention further relates to a sampler for carrying out a method of this kind.
An adapter housing is described that can be used for high performance liquid chromatography, which can be releasably connected to a socket unit. The adapter housing includes a bore which passes through the adapter housing and a pre-column which can be arranged in the bore to protect the separation column from contaminants and/or to concentrate the fluid to be analyzed. A sealing element seals the adapter housing in relation to the socket unit at the end-face wall of a pilot bore.
B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
F16L 21/035 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings placed around the spigot end before connection
F16L 21/04 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings in which sealing rings are compressed by axially-movable members
F16L 55/00 - Devices or appurtenances for use in, or in connection with, pipes or pipe systems
G01N 30/14 - Preparation by elimination of some components
G01N 30/46 - Flow patterns using more than one column
The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.
The invention relates to a sealing mechanism and to a method which forms the basis for the former and in which a clamping ring which loads a sealing element compensates for an operationally induced change in the volume which is available for the sealing element, as a result of which the sealing action of the sealing element can be maintained reliably even in the case of high operating pressures.
The invention relates to a positioning means for a flow cell used for optical detection, comprising a base having at least one contact face, the contact face being provided to make contact with the end of the flow cell, wherein the base has at least one reference face, which is to be aligned and/or positioned relative to the flow channel of a flow cell, and wherein the base is designed to receive a connecting piece in such a way that the latter assumes a predefined attitude and alignment relative to the flow channel.
The invention relates to a flow cell for absorption detection, in which a tube through which flow is to pass is held at its opposite ends in a supporting flange in each case and is suspended in a substantially cantilevered manner, the two supporting flanges being connected rigidly to each other in order to avoid stresses accidentally introduced into the tube.
G01N 27/08 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid which is flowing continuously
A method for producing a fluidic connection component for chromatography is described. A connection component includes a main body and at least one insert held in the main body. The main body is prefabricated with an aperture for the at least one insert. The at least one insert is connected to the main body securely and fluidically tightly by a thermal process and by making use of a thermal expansion of the main body and/or of the insert that occurs during the thermal process. The method may include a thermally induced change in volume of the main body and/or of the insert that is retained after completion of the thermal process. The material and the geometry of the main body and of the insert and the thermal process are chosen such that, after completion of the thermal treatment, there is a secure and fluidically tight connection.
B23P 19/04 - Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformationTools or devices therefor so far as not provided for in other classes for assembling or disassembling parts
B23P 11/02 - Connecting or disconnecting metal parts or objects by metal-working techniques, not otherwise provided for by first expanding and then shrinking or vice versa, e.g. by using pressure fluidsConnecting or disconnecting metal parts or objects by metal-working techniques, not otherwise provided for by making force fits
B21D 39/00 - Application of procedures in order to connect objects or parts, e.g. coating with sheet metal otherwise than by platingTube expanders
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory apparatus and instruments, for performing chromatography, namely, liquid chromatographs, chromatography columns, pipettors, dispensers, tubes and tube handlers all for laboratory use Apparatus and instruments, for performing chromatography, namely, liquid chromatographs, chromatography columns, pipettors, dispensers, tubes and tube handlers all for clinical diagnostic or medical diagnostic use
09 - Scientific and electric apparatus and instruments
Goods & Services
[ Chromatographs for laboratory use; Liquid chromatographs for laboratory use; ] Instrumentation for use in performing chromatography, namely, chromatography detectors for laboratory use
95.
Device for controlling a piston pump unit for liquid chromatography
A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.
The invention relates to a connector unit for connecting capillaries, in particular for high-performance liquid chromatography, wherein a sealing element sealing the capillary protrudes at least partially into the interior of the capillary, while a portion of the sealing element that protrudes axially from the capillary can be subjected to a compressive force that is introduced via the capillary to obtain an axial or radial plastic and/or elastic deformation.
F16L 21/02 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings
A connector unit for connecting capillaries, for high-performance liquid chromatography includes a connector capillary, a connector housing, and an annular sealing element. The connector capillary projects through a bore of the connector housing. The annular sealing element is provided on a front end region of the connector capillary and which is composed of a plastically and/or elastically deformable material. The connector capillary has an inner shell composed of a plastically and/or elastically deformable material and an outer shell which engages around the inner shell. The inner shell has a radially outwardly extending front end region which, on its own or together with the annular sealing element can generate a seal between the front end region of the connector capillary and a bushing unit.
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatographs; Liquid chromatographs; Instrumentation for use in performing chromatography, namely, chromatography detectors, in International Class 09.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical reagents; Chemical solvents; Chemical reagents, compounds and solvents for use in the clinical diagnostic field; Chemical reagents, compounds and solvents for use in the field of liquid chromatography; Chemical reagents, compounds and solvents for use with liquid chromatographs for analyzing biological or human samples in the clinical diagnostic field, in International Class 01. Liquid chromatographs and parts therefor; Laboratory apparatus and instruments for separating one or more compounds from a solution; Liquid chromatographs for use in identifying, quantifying and purifying individual components of a mixture; Laboratory apparatus and instruments, namely, chromatography columns, pipettors, dispensers, tubes and tube handlers, in International Class 09. Liquid chromatographs and parts therefor; Laboratory apparatus and instruments for separating one or more compounds from a solution; Liquid chromatographs for use in identifying, quantifying and purifying individual components of a mixture; Laboratory apparatus and instruments, namely, chromatography columns, pipettors, dispensers, tubes and tube handlers; All of the foregoing for clinical diagnostic or medical diagnostic use, in International Class 10.
