Abstract

An image encoding/decoding method, device and recording medium of the present disclosure may include deriving an atlas boundary from a reference sample region of a current block, determining, in response to the existence of the atlas boundary, whether an index of a reference sample line having the atlas boundary is greater than a threshold value, and adaptively transmitting a multiple reference line (MRL) syntax of the current block encoded by a changed binarization method based on the atlas boundary according to whether an index of a reference sample line having the atlas boundary is greater than a threshold value.

IPC Classes  ?

• H04N 19/70 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals characterised by syntax aspects related to video coding, e.g. related to compression standards
• H04N 19/117 - Filters, e.g. for pre-processing or post-processing
• H04N 19/176 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being an image region, e.g. an object the region being a block, e.g. a macroblock

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating bone diseases, and more specifically, includes a TCP-(MP)-Caffeic acid analogue, and thus can inhibit osteoclast differentiation and/or generation and exhibit an excellent prevention or treatment effect on various bone diseases including osteoporosis and the like.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a method for manufacturing a copper foil having a porous structure. A method for manufacturing a copper foil having a porous structure according to one aspect of the present invention may comprise the steps of: preparing a plating solution containing copper ions and at least one of chlorine ions or SPS; dipping an oxidation electrode and a reduction electrode in the plating solution; and manufacturing a copper foil by reducing the copper ions by applying a current to the plating solution, wherein the driving force required for the nucleation of the copper ions is reduced by at least one of the chlorine ions or the SPS contained in the plating solution.

IPC Classes  ?

• C25D 1/04 - WiresStripsFoils
• C25D 1/20 - Separation of the formed objects from the electrodes

Abstract

The present invention relates to a composition comprising eriocitrin as an active ingredient. The composition was confirmed to have the effects of inhibiting canalization and cell migration and increasing the apoptosis of HUVECs. It was also confirmed that the chick chorioallantoic membrane (CAM) has the effect of inhibiting capillary formation in an in vivo model. Therefore, the composition can be effectively used for preventing, treating or ameliorating angiogenesis-related diseases by inhibiting angiogenesis, due to having the effects.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a composition comprising luteolin 7-O-glucoside as an active ingredient. It has been confirmed that the composition has an effect of inhibiting lumen formation and cell migration, and an effect of increasing apoptosis of HUVECs. In addition, it has been confirmed that the composition has an effect of inhibiting chick chorioallantoic membrane (CAM) capillary formation in an in vivo model. Therefore, the composition can be effectively used for preventing, treating, or alleviating angiogenesis-related diseases by inhibiting angiogenesis by having the effects.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 27/02 - Ophthalmic agents
• A61P 35/00 - Antineoplastic agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present specification provides a method for transmitting and receiving a signal with low power in a communication system. More specifically, the method performed by a second terminal comprises the steps of: transmitting and receiving a first signal to and from a first terminal through a monitoring duration of a sidelink, wherein the monitoring duration includes a listening duration and a receiving duration; harvesting energy through the listening duration; and transmitting a second signal on the basis of the harvested energy.

IPC Classes  ?

• H04L 12/28 - Data switching networks characterised by path configuration, e.g. LAN [Local Area Networks] or WAN [Wide Area Networks]
• H04W 52/02 - Power saving arrangements

Abstract

The present invention relates to an ultra-fine electrode using a low melting point metal and a method for manufacturing same. A method for manufacturing an ultra-fine electrode using a low melting point metal according to one aspect of the present invention comprises the steps of: preparing an insulation member having a hollow formed along the longitudinal direction; filling the hollow of the insulation member with a liquid metal having a melting point of 25-400°C; cooling and solidifying the metal filled in the hollow of the insulation member; and forming a necking on the insulation member and the metal, and fracturing the necked portion to manufacture the ultra-fine electrode.

IPC Classes  ?

• G01Q 60/60 - SECM [Scanning Electro-Chemical Microscopy] or apparatus therefor, e.g. SECM probes
• G01Q 70/16 - Probe manufacture

Abstract

The present invention relates to a pharmaceutical composition comprising graphene quantum dots as an active ingredient for preventing or treating neurodegenerative diseases and, more specifically, to a pharmaceutical composition comprising graphene quantum dots to inhibit the formation of stress granules or protein aggregates, whereby the composition is capable of exhibiting excellent efficacy against neurodegenerative diseases, which are TDP -43 proteinous diseases.

IPC Classes  ?

• A61K 33/44 - Elemental carbon, e.g. charcoal, carbon black
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The provided method for evaluating erosion resistance of a reactor valve is capable of quick and accurate measurement. According to a first aspect of the present invention, the provided method for evaluating erosion resistance of a reactor valve comprises the steps of: (S1) regulating the temperature and flow rate of fluid supplied from a supply part including a first pump; and (S2) providing the regulated fluid to an erosion resistance measurement part having a control valve, wherein the open state of the control valve is regulated to be less than 58%.

IPC Classes  ?

• G01M 13/003 - Machine valves
• G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light
• G21C 17/017 - Inspection or maintenance of pipe-lines or tubes in nuclear installations
• F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given

Abstract

The present invention reveals that PDH can be utilized as a new target for the treatment of neuropathy and, based on this finding, provides preventive and therapeutic agents for neuropathy. Additionally, the present invention provides a method for screening candidate substances for neuropathy prevention and treatment. The screening method of the present invention allows for the effective selection of new candidate substances that can prevent and/or treat neuropathy, and the substances selected by the screening method can be used to provide a pharmaceutical composition for the prevention and treatment of neuropathy.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a novel biomarker for diagnosing cancer, and a use thereof. STC1, a novel biomarker for diagnosing or predicting the prognosis of cancer according to the present invention, was found to be related to poor prognosis of cancer patients according to the expression level, and was found to be overexpressed in various cancer cell lines. In addition, STC1 was found to be a biomarker related to the proliferation, invasion, and migration (metastasis) of cancer cells. In addition, it was found that STC1 is detected in the serum or urine of bladder cancer patients, and can be effectively used for diagnosing and predicting the prognosis of bladder cancer by identifying differences in expression according to the patient's clinical stage.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection

Abstract

The present invention relates to a pharmaceutical composition and the like for preventing or treating peripheral neuropathy, and has been completed by the identification that a diphenyl ether derivative isolated from a marine organism specifically promotes mitophagy activity, and thus can exhibit a peripheral neuropathy treatment effect. Specifically, the compound according to the invention independently promotes mitophagy in the PINK1-Parkin pathway so as to alleviate hyperalgesia, which is a representative symptom of peripheral neuropathy, and can effectively alleviate anti-cancer agent-induced mitochondrial dysfunction of sensory nerves. In particular, the compound of the present invention does not damage mitochondrial function or inhibit cell growth, and thus can be used as a safe therapeutic drug. Therefore, a diphenyl ether derivative according to the present invention has low risk of side effects and enables fundamental treatment of peripheral neuropathy through mitophagy promotion, and thus is expected to be effectively used as a drug for preventing and treating peripheral neuropathy.

IPC Classes  ?

• A61K 31/085 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

244 as a copper precursor, and not only is it expected to reduce costs, but also has the potential for high-yield copper nanowire synthesis through additional process control in the future.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• B22F 1/054 - Nanosized particles

Abstract

The present invention relates to an electrolytic plating apparatus for surface modification of a pipe. The technical subject matter according to one aspect of the present invention is an electrolytic plating apparatus for modifying the surface of a pipe, the apparatus comprising: a housing having an inner space in which electrodes, a plating solution and a pipe can be accommodated, and having, at the lower surface thereof, a plating solution inlet into which the plating solution is injected; a plating auxiliary part which is provided in the housing so as to vertically fix the pipe inserted into the housing, and which guides that the plating solution flows toward the upper portion of the housing if the solution is injected into the housing; and an auxiliary support part which is provided in the housing so as to separate the plating auxiliary part a predetermined distance from the plating solution inlet, and which guides that the plating solution having flowed in through the plating solution inlet flows toward the plating auxiliary part.

IPC Classes  ?

• C25D 17/02 - TanksInstallations therefor
• C25D 7/04 - TubesRingsHollow bodies
• C25D 17/08 - Racks
• C25D 17/10 - Electrodes
• C25D 21/12 - Process control or regulation

Abstract

The electroplating apparatus for surface modification of pipes includes: a housing comprising an inner space accommodating an electrode, a plating solution, and a pipe therein, and a plating solution inlet disposed on a lower surface of the housing and allowing the plating solution to be injected therethrough; a plating auxiliary part disposed inside the housing, vertically fixing the pipe inserted into the housing, and guiding the plating solution injected into the housing to flow toward an upper portion of the housing; and an auxiliary support part disposed inside the housing, spacing the plating auxiliary part and the plating solution inlet apart from each other by a predetermined distance, and guiding the plating solution introduced through the plating solution inlet to flow in a direction, where the plating auxiliary part is disposed.

IPC Classes  ?

• C25D 17/02 - TanksInstallations therefor
• C25D 7/04 - TubesRingsHollow bodies
• C25D 17/08 - Racks
• C25D 21/12 - Process control or regulation

Abstract

The objective of the present invention is to provide an anti-inflammatory or antioxidant composition comprising benzyl caffeate as an active ingredient. Benzyl caffeate has no cytotoxicity, and was confirmed to inhibit the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in a concentration-dependent manner. Benzyl caffeate was also confirmed to inhibit the production of inflammatory cytokines and reactive oxygen species (ROS), and thus can be effectively used in related industries.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 21/20 - Products from apiculture, e.g. royal jelly or pollenSubstitutes therefor
• A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
• A61K 35/644 - BeeswaxPropolisRoyal jellyHoney
• A23K 10/20 - Animal feeding-stuffs from material of animal origin

Abstract

The present invention relates to a check valve which can easily adjust cracking pressure without replacement of a spring though screw-type adjusting of the elastic force of the spring, and which can prevent the occurrence of chattering. The check valve according to one aspect of the present invention may comprise: a first valve body connected to a pipe through which fluid is supplied; a seat, which is disposed at the front end portion of the first valve body and has a flow path on which the fluid flowing through the pipe flows; a poppet, which is movably provided in an inner space of the first valve body so as to open/close the flow path while coming into close contact with or being spaced apart from the rear end portion of the seat; the spring for providing the elastic force by which the poppet is pressed toward the seat in the inner space of the first valve body; a spring support member, which is provided at the rear end portion of the first valve body so as to be movable in the forward and backward directions, and supports the rear end portion of the spring; a second valve body, which communicates with the rear end portion of the first valve body and is connected to the pipe through which the fluid is discharged; and an elastic force adjustment member, which is disposed between the rear end portion of the first valve body and the front end portion of the second valve body so as to move the spring support member in the forward and backward directions with respect to the first valve body by means of external force, thereby adjusting the elastic force of the spring.

IPC Classes  ?

• F16K 15/02 - Check valves with guided rigid valve members
• F16K 47/02 - Means in valves for absorbing fluid energy for preventing water-hammer or noise
• F16K 17/02 - Safety valvesEqualising valves opening on surplus pressure on one sideSafety valvesEqualising valves closing on insufficient pressure on one side
• F16K 31/50 - Mechanical actuating means with screw-spindle
• F16K 31/60 - Handles

Abstract

The present disclosure relates to an organic compound including at least one carbazolyl moiety fused with an alicyclic or hetero alicyclic ring and linked to directly or via a linker to a triazine moiety and at least one blocking moiety linked the triazine moiety, an organic light emitting diode and an organic light emitting device including the organic compound. The organic compound can implement high luminous efficiency as enhancing delayed fluorescent property, minimize reduction of the luminous lifespan caused by substituent degradation, and can secure high triplet energy level owing to no conjugation extensions. The organic light emitting diode and the organic light emitting device using the organic compound can have beneficial luminous efficiency and the luminous lifespan.

IPC Classes  ?

• H10K 85/40 - Organosilicon compounds, e.g. TIPS pentacene
• C07F 7/08 - Compounds having one or more C—Si linkages
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The present invention relates to a grass preservation system using vegetation identification through multispectral image information and a grass preservation method using the same system, the system comprising: an unmanned aerial vehicle, which can fly and capture a multi-spectral image; a pre-processing unit, which can correct an irregular spectrum in the multispectral image captured by means of the unmanned aerial vehicle; a post-processing unit for turning the multispectral image into an ortho-image processed into continuous images; and a vegetation analysis unit, which analyzes a vegetation index of grass through the ortho-image so that vegetation density, vitality, chlorophyll changes, crop health, nutrient stress, disease, growth and aging can be quantified by means of the vegetation index, wherein the vegetation analysis unit enables the grass vegetation index to be analyzed through a calculation formula according to a first vegetation index combination and a calculation formula according to a second vegetation index combination.

IPC Classes  ?

• G06Q 50/26 - Government or public services
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

The present invention relates to a device for monitoring green algae in a river with habitual green algae by using a hyperspectral sensor. More specifically, the device comprises: an unmanned aerial photographing part configured to fly over a river with green algae and acquire a hyperspectral image of the river by using a hyperspectral sensor; a plurality of ground-based photographing parts arranged along the river with green algae and photographing the water surface of the river by using a hyperspectral sensor; a river water sensor part for identifying the water temperature, flow rate, and green algae concentration of the river water at a spot photographed by the ground-based photographing part; a memory part for storing sensing data obtained by the river water sensor part; a data matching part for matching the hyperspectral image acquired by the ground-based photographing part to the sensing data stored in the memory part; and a pre-processing part for aligning the hyperspectral images acquired by the unmanned aerial photographing part and the ground-based photographing part, so as to correct irregular spectra. In addition, according to the present invention, green algae in a river is continuously spectrally photographed to acquire spectroscopic image data while simultaneously identifying information on the water temperature, flow rate, and green algae concentration at the spectroscopically photographed spot, and then the spectroscopic image data and the information are integrated to establish comprehensive information related to river green algae, thereby efficiently managing rivers through established database.

IPC Classes  ?

• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 33/18 - Water
• G01P 5/00 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft
• G01K 1/02 - Means for indicating or recording specially adapted for thermometers
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• G06Q 50/10 - Services
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The purpose of the present invention is to provide a composition containing agents causative of chalkbrood and foulbrood as active ingredients for immune activation in bees. It was found in the present invention that a mixture of heat-killed agents causative of chalkbrood and foulbrood enhances and activates the immune system of bees. It was also found that when fed with a peppermint oil-added mixture of the heat-killed agents causative of chalkbrood and foulbrood, bees increase in weight and showed the upregulated expression of development-related genes. Furthermore, pollen cakes and honey dilutions prepared from a mixture of heat-killed agents causative of chalkbrood and foulbrood increased the survival rate against foulbrood in brood larvae within the bee colony, and thus can be advantageously used for related businesses.

IPC Classes  ?

• A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
• A23K 50/90 - Feeding-stuffs specially adapted for particular animals for insects, e.g. bees or silkworms
• A23K 20/158 - Fatty acidsFatsProducts containing oils or fats
• C12N 1/14 - Fungi Culture media therefor
• C12N 1/20 - BacteriaCulture media therefor

Abstract

The present invention relates to: a support for a vacuum insulation pipe, which is disposed between an inner pipe and an outer pipe of the vacuum insulation pipe for transferring a cryogenic fluid such as liquefied natural gas while preventing heat loss thereof; and a vacuum insulation pipe having the support. According to the present invention, a support for a vacuum insulation pipe including an inner pipe in which a cryogenic fluid flow, an outer pipe installed outside the inner pipe to be spaced a predetermined distance apart therefrom, and a vacuum layer formed between the inner pipe and the outer pipe may include: a support body formed in the vacuum layer to extend along the circumferential direction thereof; multiple inner support parts arranged on the support body while having predetermined intervals along the circumferential direction and formed to protrude inward in the radial direction thereof so as to be in close contact with the outer circumferential surface of the inner pipe; and multiple outer support parts arranged on the support body and between the inner support parts, and formed to protrude outward in the radial direction so as to be in close contact with the inner circumferential surface of the outer pipe.

IPC Classes  ?

• F16L 59/065 - Arrangements using an air layer or vacuum using vacuum
• F16L 59/12 - Arrangements for supporting insulation from the wall or body insulated, e.g. by means of spacers between pipe and heat-insulating materialArrangements specially adapted for supporting insulated bodies

Abstract

The present invention relates to a hydraulic compressor channel switching valve wherein the channel is switched by a sliding operation of a stem, and buffering of the stem and flow rate adjustment are possible. The hydraulic compressor channel switching valve according to an aspect of the present invention may comprise: a valve body comprising a valve chamber having an inlet and first and second outlets formed through a side surface thereof such that a fluid is introduced and discharged therethrough, respectively; a channel opening/closing member comprising a stem installed inside the valve chamber of the valve body to be able to move in the axial direction, a first disk formed on the outer surface of the stem so as to protrude in the radial direction, thereby opening/closing the inlet and the first outlet according to the direction of movement of the stem, and a second disk formed on the outer surface of the stem so as to protrude in the radial direction and positioned to be spaced apart from the first disk by a predetermined distance in the axial direction, thereby opening/closing the inlet and the second outlet according to the direction of movement of the stem; a stem buffering member installed between one end of the stem and one side end of the valve chamber such that, when the channel opening/closing member moves in the axial direction inside the valve chamber and thus switches the channel, the stem buffering member makes contact and absorbs shocks; and a valve operating member installed inside the valve chamber and connected to the other end of the stem so as to move in the axial direction with regard to the valve chamber, thereby moving the stem.

IPC Classes  ?

• F04B 39/10 - Adaptation or arrangement of distribution members
• F04B 39/00 - Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups
• F16K 11/065 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with linearly sliding closure members
• F16K 47/02 - Means in valves for absorbing fluid energy for preventing water-hammer or noise
• F16K 25/00 - Details relating to contact between valve members and seats

Abstract

The present invention relates to: a pharmaceutical composition for preventing or treating Melas syndrome; and the like, and has been completed by identifying that an isopquinoline derivative, discovered through mitophagy activity-based screening, exhibits an excellent mitophagy promotion effect, and thus can be used as a fundamental therapeutic agent for Melas syndrome. Particularly, an isopquinoline derivative according to the present invention promotes mitophagy activity and remarkably alleviates mitochondria dysfunction in Melas syndrome cell models and in cells derived from Melas syndrome patients. Therefore, the isopquinoline derivative is expected to be effectively used, in the field of prevention, alleviation and treatment of the disease, as a fundamental therapeutic agent capable of inhibiting the cause of Melas syndrome.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating peripheral neuropathy, and the like. The present invention has been completed by confirming that an isoquinoline derivative discovered through a screening based on mitophage activity exhibits an excellent mitophage promoting effect, and thus, the isoquinoline derivative can be utilized as a fundamental therapeutic agent for peripheral neuropathy. Specifically, it has been found that the isoquinoline derivative according to the present invention treats hyperalgesia in an animal model of anticancer drug-inducible peripheral neuropathy, also suppresses morphological changes of sensory nerves, which have been identified as a key cause of peripheral neuropathy, and can increase the distribution and number of peripheral nerves. Therefore, the isoquinoline derivative according to the present invention is a fundamental therapeutic agent capable of suppressing the main symptoms and causes of peripheral neuropathy, particularly, anticancer drug-induced peripheral neuropathy, and is expected to be usefully utilized in the field of prevention, amelioration, and/or treatment of the disease.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The purpose of the present invention is to provide a composition for preventing or treating neurodegenerative disorders, comprising humanin peptide as an active ingredient. When the humanin peptide of the present invention was administered nasally to a mouse model of Parkinson's disease, it was confirmed that the humanin peptide was effectively delivered and distributed to the brain. In addition, it was confirmed that dopamine neuron expression increased and neuron cell damage was suppressed. Further, it was confirmed that the humanin peptide suppresses neuron cell damage in a Parkinson's disease cell model, thus being effective in treating Parkinson's disease, and as a result can be utilized in related businesses.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention relates to a pharmaceutical composition for the prevention or treatment of Parkinson's disease. Leading to the present invention, an isoquinoline derivative, identified through screening based on mitophagy activation, was found to exhibit an excellent effect in promoting mitophagy and proved to be a fundamental therapeutic agent for Parkinson's disease. Specifically, the isoquinoline derivative according to the present invention not only reduces mitochondrial dysfunction closely associated with Parkinson's disease in a Parkinson's disease animal model but also ameliorates motor function impairment in the Parkinson's disease animal model. Particularly, in the Parkinson's disease animal model treated with the isoquinoline derivative according to the present invention, the demise of dopaminergic neurons, a primary cause of Parkinson's disease, was effectively inhibited. Thus, the isoquinoline derivative according to the present invention is expected to be advantageously utilized as a fundamental therapeutic agent in the field of prevention, alleviation, and/or treatment of Parkinson's disease.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 25/16 - Anti-Parkinson drugs
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

In the present invention, differential expression of 23 genes has been identified, which are GATA3, FOXA1, RASSF5, PTPN6, TRNP1, APOBEC3D, APOBEC3G, ABL1, ABL2, CACNA2D1, JUN, GNG4, NGF, MYC, MAP4K4, STC1, FOXD1, FOXC2, TGFB1, TGFB3, NOG, SMAD9, and NT5E, and it has been confirmed that expression of the 23 genes correlates with the prognosis and survival of bladder cancer patients and thus can be used as biomarkers for diagnosing anticancer drug-resistant bladder cancer, or predicting metastasis or making a prognosis thereof. In addition, it has been confirmed that, as a bladder cancer cell line acquires resistance, the ability for tumor infiltration and migration increases and the resistance to an anticancer drug also increases, and that the 23 genes are differentially expressed as a bladder cancer cell line acquires resistance to an anticancer drug. Further, it has been confirmed that, upon administration of an anticancer drug-resistant bladder cancer cell line to mice, the ability for tumor proliferation and metastasis increases, and that the expression of the 23 genes also increases in a mouse tumor. As such, the present invention is effective in making a diagnosis, prognosis, or metastasis prediction of cancer and also exhibits an excellent effect in diagnosing anticancer drug-resistant cancer, and thus would be useful in related industries.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A method of manufacturing a multilayer metal plate by electroplating includes a first forming operation of forming one of a first metal layer and a second metal layer on a substrate by electroplating, wherein the second metal layer is less recrystallized than the first metal layer, the second metal layer is comprised of nanometer-size grains, and the second metal layer has a higher level of tensile strength than the first metal layer; and a second forming operation of forming, by electroplating, a third metal layer not formed in the first forming operation on a surface of one of the first metal layer and the second metal layer formed in the first forming operation.

IPC Classes  ?

• C25D 5/12 - Electroplating with more than one layer of the same or of different metals at least one layer being of nickel or chromium
• C25D 3/12 - ElectroplatingBaths therefor from solutions of nickel or cobalt
• C25D 3/38 - ElectroplatingBaths therefor from solutions of copper
• C25D 5/00 - Electroplating characterised by the processPretreatment or after-treatment of workpieces
• C25D 21/12 - Process control or regulation
• H01M 4/66 - Selection of materials

Abstract

The present invention relates to a soft covering structure for a robot to which a metastructure is applied, being coupled to cover the outer surface of a robot hand or a certain part of the robot to provide elasticity and flexibility and being manufactured by a 3D-printing method. The soft covering structure for a robot, according to the present invention, comprises: a covering which is formed of a resin material having elasticity and is coherently coupled to the surface of the palm or the back of the robot's hand and the fingers of the robot, and has grating form in which a plurality of through-holes are formed and certain patterns are continuously arranged; and a coupling cap which is fixed to the end of the part of the covering that is coherently coupled to the fingers of the robot, and has a cylindrical shape having at least one open side surface so that the end of the robot's finger can be inserted through the open side surface to be coupled.

IPC Classes  ?

• B25J 15/00 - Gripping heads
• B25J 15/08 - Gripping heads having finger members
• B25J 9/00 - Programme-controlled manipulators

Abstract

A check valve for cryogenic fluid includes: a valve body which is formed to have an inlet and an outlet open at both ends thereof, a valve seat which is formed inside the valve body to communicate with the inlet; a disk which is pivoted up and down at the upper end thereof about a pivot axis provided in the valve body to open and close the valve seat; and a sealing member which is made of a metal material shrinkable by cryogenic fluid introduced through the inlet, is provided in the circumferential direction of the valve seat, and when the disk closes the valve seat, is brought into close contact with the edge portion of the disk to produce sealing effects.

IPC Classes  ?

• F16K 15/03 - Check valves with guided rigid valve members with a hinged closure member
• F16K 47/02 - Means in valves for absorbing fluid energy for preventing water-hammer or noise

Abstract

The present invention relates to a use of PDH inhibitors in the treatment of neurodegenerative diseases, and according to the present invention, in a DJ-1 deletion Parkinson's disease Drosophila model, by activation of PDK, promotion of PDK expression through DJ-1 and HIF-1, inhibition of PDP, or genetic and pharmacological inhibition of PDH using PDH inhibitors, sensitivity to ROS was lowered, and death of dopaminergic neurons was significantly reduced, and accordingly, the PDH inhibitors can be used in the prevention or treatment of neurodegenerative diseases.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to an animal model of Charcot-Marie-Tooth disease caused by K141N or K141T mutations in HSPB8. In this animal model expressing the K141N or K141T mutant HSPB8 protein, symptoms of Charcot-Marie-Tooth disease, such as motor deficit, mitochondrial dysfunction, and reduced levels of mitophagy, were observed, confirming that Charcot-Marie-Tooth disease can be induced by K141N or K141T mutations in the HSPB8 protein. Therefore, the animal model expressing the K141N or K141T mutant HSPB8 protein can be used as an animal model of Charcot-Marie-Tooth disease. The symptoms of Charcot-Marie-Tooth disease were significantly reduced by the expression and activation of PINK1 or Parkin, so that the animal model can be used in therapeutic applications for Charcot-Marie-Tooth disease.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 38/45 - Transferases (2)
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates

Abstract

ATP8B1, CCND1, CDH12, FERMT1, HSPD1, HSPE1, ID3, MAML3, CDKN1A, ELF4,MCM3, AREG, BMP6, CAV1, CAV2, COL8A2, CTSK, EBI3, EREG, GSN, ITGA2B, JAK3, L1CAM, LAMA3, LAMC2, LCN2, OLFML2A, PDGFC, PRKCG, SSC5D, THBS3, VASN, MMP3, SERPINB2, VCAN, ZP3, ACTA2, CACNA2D1, FAS, PDGFRB, SH3PXD2A, TAGLN, ACP2, CTSD, MMP11, TPP1, CD44, ESM1, FOXD1, HEG1, TCF4, VEGFC, ABL1, APOLD1, BDNF, DZIP1, LEF1, MYC, NAV1, NRP2, PKDCC, TMCC3CDACDA is increased in bladder cancer cells with increased infiltration and metastasis. In addition, it was discovered that selected genes are associated with metastasis and prognosis of cancer in bladder cancer patients.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to a composition for diagnosis of Charcot-Marie-Tooth disease and an information provision method for diagnosis thereof. The composition can be effectively used to diagnose Charcot-Marie-Tooth disease and determine the severity thereof, by detection of p62 protein in serum or plasma and measurement of the concentration thereof to compare same with a control group.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a novel berberine analogue CD1-410. It has been identified that the novel berberine analogue promotes the activity of mitophagy, and thus can reduce mitochondria with a damaged structure and/or function. Therefore, the novel berberine analogue according to the present invention can be used for preventing, alleviating and/or treating various diseases that can be caused by abnormal mitochondria.

IPC Classes  ?

• C07D 491/147 - Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
• A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to novel isoquinoline derivatives. The derivatives have an effect of promoting mitophagy activity, thereby reducing mitochondria with structural and/or functional damage. In particular, the novel isoquinoline derivatives according to the present invention do not induce mitochondrial dysfunction and have been identified as safe compounds that are non-toxic to cells, and thus can be utilized for the prevention, amelioration, and/or treatment of various diseases that may be caused by abnormal mitochondria.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to an Interferon Gamma Inducible Protein 16 (IFI16) mutant gene as a marker for predicting, diagnosing, or prognosing the risk of chronic liver disease, and a use thereof. In the present invention, it was found from the genomic analysis performed on NAFLD and NASH patient groups that the frequency of IFI16 single-nucleotide variants (SNVs) including rs2276404, rs73021847, rs7532207, and rs6940 increased. Additionally, an increase in the expression of the IFI16 mutant gene was confirmed according to the stages of liver disease. Furthermore, it was found in the present invention that IFI16 SNVs were significantly expressed in infiltrated macrophages and played a crucial role in the macrophage-induced inflammatory process. The IFI16 mutants were observed to bind more strongly to dsDNA than wild-type IFI16, exacerbating the damage signal of the mitochondrial DNA detection response in the IFI16-PYCARD-CASP1 pathway. Therefore, the IFI16 mutant gene of the present invention can be advantageously utilized for predicting, diagnosing, or prognosing the risk of chronic liver disease.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

NN 4-isobutyryloxycytidine analog synthesis and to the anti-viral use thereof against dengue virus, influenza virus, and SARS-CoV-2 virus.

IPC Classes  ?

• C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

The present invention relates to a method for synthesizing Avenanthramides C. The method allows synthesis to be high-yielding despite using a reagent that is easy to manipulate relative to those used in existing synthesis methods, and thus the method can be useful in large-scale production of Avenanthramides C.

IPC Classes  ?

• C07C 231/14 - Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
• C07C 235/38 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

The present invention relates to a container, specifically a container in which an electronic equipment package is mounted so as to be accommodated in a groove portion of a corrugated panel, wherein: the groove portion is a recessed space portion and extends to a predetermined length along a first central axis; the electronic equipment package has a shape corresponding to the groove portion so as to allow mounting therein; and the height of the electronic equipment package protruding from the corrugated panel is not greater than a predetermined value. According to the present invention, mounting the electronic equipment package is easy, the installation space thereof is reduced, the risk of damage to the electronic equipment package due to an external impact occurring during container handling is low, and the risk of theft is also low.

IPC Classes  ?

• B65D 90/48 - Arrangements of indicating or measuring devices
• B65D 90/02 - Wall construction
• B65D 88/10 - Large containers rigid parallelepipedic
• B65D 88/12 - Large containers rigid specially adapted for transport

Abstract

The present invention relates to a 3D virtual space-based crowd behavior simulation device comprising: a destination input unit that receives input, from a user, of a selection of one among a plurality of vertices constituting a stacked-type multi-story building model as a destination vertex; a destination affordance field generating unit for generating a destination affordance field corresponding to a vector field representing a slope of a scalar field according to a distance between an arbitrary vertex and the destination vertex when a heat transfer amount on the basis of a predetermined scalar-based heat transfer amount function is assigned to the plurality of vertices; a collision avoidance affordance field generating unit for, when a plurality of agents are disposed on a plane with normal vectors in different directions included in the multi-story building model, generating a collision avoidance affordance field for inducing collision avoidance according to a repulsive force acting on at least one agent adjacent to each other on the basis of the positions of the respective plurality of agents; and a simulation generating unit that generates a simulation image of a movement in which the plurality of agents move toward a predetermined destination inside the multi-story building model according to a steering force acting on the plurality of agents by a combination of the destination affordance field and the collision avoidance affordance field.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06T 15/04 - Texture mapping
• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
• G09B 9/00 - Simulators for teaching or training purposes

Abstract

The present invention relates to a system for recognizing the state of a door sealing device of a smart container, and a control method thereof, wherein the sealing device, which can perform a physical sealing (lock) function and a door open and closed state and door sealed state sensing function, is installed on a container door and a locking load of the container door, and makes it possible to remotely perform a sealing or unsealing operation and monitor the open and closed state of the door and the sealing state of the sealing device by means of a control module that can communicate wirelessly with an external mobile communication terminal or a server.

IPC Classes  ?

• B65D 90/48 - Arrangements of indicating or measuring devices
• B65D 90/66 - Operating devices therefor
• E05B 73/00 - Devices for locking portable objects against unauthorised removalLocking devices not provided for in other groups of this subclass

Abstract

The present invention provides a composition effective in preventing, ameliorating, or treating obesity or fatty liver comprising Momordica charantia leaf extract or hydroferulic acid derived from Momordica charantia as an active ingredient. The composition may be effectively used throughout food or pharmaceutical industries.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A23K 20/111 - Aromatic compounds

Abstract

A porous silicon manufacturing method according to the present invention comprises the steps of: pretreating a silicon precursor and a heat dispersant; and conducting a thermal reduction reaction between the heat dispersant-pretreated silicon precursor and a metal reducing agent by using a rotary reaction chamber. When porous silicon manufactured by the manufacturing method is contained in a secondary battery anode active material and used in secondary batteries, the batteries exhibit high capacity and long lifespan characteristics. The present invention relates to a method for manufacturing porous silicon and a method for manufacturing a secondary battery anode active material containing the porous silicon manufactured thereby, with the aim of solving the problems with silicon materials under development for anode active materials for lithium secondary batteries, including excessive volume expansion during charge/discharge and resultant electrode fracture and lifespan shortening.

IPC Classes  ?

• C01B 33/021 - Preparation
• H01M 10/052 - Li-accumulators
• C01B 33/037 - Purification

Abstract

The present invention relates to an optical compensation film for improving optical characteristics of an organic light-emitting device, and the technical gist thereof is to include: a positive C-plate; a negative biaxial retardation film that is stacked on the C-plate and has reverse-wavelength dispersion; and a polarizer stacked on the negative biaxial retardation film.

IPC Classes  ?

• G02B 5/30 - Polarising elements

Abstract

An anticancer adjuvant for treating anticancer-agent-resistant cancer includes a tristetraprolin inhibitor. If resistance to DNA replication inhibitory anticancer agents is exhibited, a substance for inhibiting the activity of tristetraprolin can be included as an anticancer adjuvant so as to maximize the effects of an anticancer agent, and thus is usable in cancer treatment.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61K 33/243 - PlatinumCompounds thereof
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The multilayer copper foil includes: a recrystallization active layer disposed on a surface of a substrate; and a recrystallization suppressing layer disposed on a surface of the recrystallization active layer to inhibit recrystallization of the recrystallization active layer, wherein a concentration of impurities within the recrystallization suppressing layer is greater than a concentration of impurities within the recrystallization active layer.

IPC Classes  ?

• C25D 1/04 - WiresStripsFoils
• C25D 3/38 - ElectroplatingBaths therefor from solutions of copper
• C25D 5/10 - Electroplating with more than one layer of the same or of different metals
• C25D 17/00 - Constructional parts, or assemblies thereof, of cells for electrolytic coating
• C25D 21/12 - Process control or regulation

Abstract

The present invention relates to a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, which, by inhibiting the replication of an RNA virus by being integrated as a nucleotide derivative into a polymerase of the RNA virus and inducing inhibitory activity, suppresses the proliferation of influenza A, influenza B, dengue virus, West Nile virus, HIV, and the like, and thus can be used as a novel and effective anti-viral agent.

IPC Classes  ?

• C07D 233/61 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/415 - 1,2-Diazoles
• A61K 31/4196 - 1,2,4-Triazoles
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 31/18 - Antivirals for RNA viruses for HIV
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

The present invention relates to a novel biomarker for diagnosing cancer, and a use thereof. STC1, a novel biomarker for diagnosing or predicting the prognosis of cancer according to the present invention, was found to be related to poor prognosis of cancer patients according to the expression level, and was found to be overexpressed in various cancer cells. In addition, STC1 was found to be a biomarker related to the proliferation, invasion, and migration (metastasis) of cancer cells. In addition, it was found that STC1 is detected in the serum or urine of bladder cancer patients, and can be effectively used for diagnosing and predicting the prognosis of bladder cancer by identifying differences in expression according to the patient's clinical stage.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A slim double-skin structure according to one aspect of the present invention may comprise: a window frame, an outer window sash frame provided on an outdoor side and coupled to the window frame, an outer glass provided on the outer window sash frame, an inner window sash frame provided on an indoor side and coupled to the window frame, an inner glass provided on the inner window sash frame, an awning film provided in a hollow layer formed between the outer glass and the inner glass to serve as a shading, and a case-type glass fixing frame which is provided in the outer window sash frame so as to be located in the hollow layer and fixes the outer glass to the outer window sash frame concurrently with building-in and guiding the awning film.

IPC Classes  ?

• E06B 3/67 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges characterised by additional arrangements or devices for heat or sound insulation

Abstract

The present invention relates to an apparatus tor transmitting an ultra-high frequency signal based a multi-level PAM system, and comprises at least one PAM module comprising: a first signal output unit that outputs a first amplified signal by receiving, as an input, and amplifying a differential pair of LO voltage signals on the basis of a first constant current source; a second signal output unit that outputs a second amplified signal by receiving, as an input, and amplifying a differential pair of LO voltage signals on the basis of a second constant current source; and a level modulation unit that outputs an offset or amplified modulated signal by modulating the first amplified signal and the second amplified signal to be out of phase or in phase with each other according to a high-level or low-level signal corresponding to a digital input signal, and then summing the modulated signals.

IPC Classes  ?

• H04L 25/02 - Baseband systems Details
• H04L 25/49 - Transmitting circuitsReceiving circuits using code conversion at the transmitterTransmitting circuitsReceiving circuits using predistortionTransmitting circuitsReceiving circuits using insertion of idle bits for obtaining a desired frequency spectrumTransmitting circuitsReceiving circuits using three or more amplitude levels

Abstract

The present invention relates to a check valve for cryogenic fluid, which can be installed at, for example, the mouth of a pipe for injecting cryogenic hydrogen gas into a compressor cylinder in a hydrogen compressor. The check valve for cryogenic fluid according to an aspect of the present invention comprises: a valve body which is formed to have an inlet and an outlet open at both ends thereof; a valve seat which is formed inside the valve body to communicate with the inlet; a disk which is pivoted up and down at the upper end thereof about a pivot axis provided in the valve body to open and close the valve seat; and a sealing member which is made of a metal material shrinkable by cryogenic fluid introduced through the inlet, is provided in the circumferential direction of the valve seat, and when the disk closes the valve seat, is brought into close contact with the edge portion of the disk to produce sealing effects.

IPC Classes  ?

• F16K 15/02 - Check valves with guided rigid valve members
• F16K 31/00 - Operating meansReleasing devices
• F16K 47/02 - Means in valves for absorbing fluid energy for preventing water-hammer or noise

Abstract

The present invention relates to a butterfly-type gate valve capable of shortening an opening/closing time and reducing in size through two opening/closing members in the form of semicircular discs folding or unfolding to allow for adjustment of the degree of opening of a valve flow path and enable opening/closing of the valve flow path. The butterfly-type gate valve according to the present invention comprises: a valve body having a flow path in which an inlet for introducing a fluid and an outlet for discharging the fluid are formed in a front portion and a rear portion, respectively; a first opening/closing member and a second opening/closing member in the form of semi-circular discs that open or close the flow path by being folded or unfolded while rotating in opposite directions inside the flow path of the valve body; and a driving means which transmits a rotational force to the first opening/closing member and the second opening/closing member.

IPC Classes  ?

• F16K 3/22 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with sealing faces shaped as surfaces of solids of revolution
• F16K 1/22 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure members with pivoted discs or flaps with axis of rotation crossing the valve member, e.g. butterfly valves
• F16K 31/04 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a motor
• F16K 31/53 - Mechanical actuating means with toothed gearing
• F16K 47/02 - Means in valves for absorbing fluid energy for preventing water-hammer or noise

Abstract

According to an embodiment, there is provided a method for mitigating seawater intrusion in the ground where an aquifer having a seawater-fresh water interface is formed, the method including: installing an injection well at a point on an inland area, spaced apart from the sea by a predetermined distance, to a predetermined injection depth (d), the injection well having a predetermined screen height; injecting seawater into the aquifer by a predetermined quantity of injection through the injection well; and forming an upper seawater area around the injection well by the injection of the seawater, wherein the upper seawater area is an area that is filled with seawater in an upper portion of the aquifer.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G01V 9/02 - Determining existence or flow of underground water
• G06F 30/20 - Design optimisation, verification or simulation

Abstract

There is provided a method for determining an optimal condition for artificial recharge by using a computer in an artificial recharge system provided with an injection well for injecting fresh water into an aquifer, the method including: a step of calculating a maximum permissible quantity of injection of fresh water to be injected into the aquifer; a step of determining a height of a screen which is an area on a side surface of the injection well where penetrating holes are formed, based on the calculated maximum permissible quantity of injection; and a step of determining an injection pressure of the fresh water to be injected into the aquifer, based on the height of the screen.

IPC Classes  ?

• E21B 47/06 - Measuring temperature or pressure
• E03B 3/08 - Obtaining and confining water by means of wells
• E21B 47/09 - Locating or determining the position of objects in boreholes or wellsIdentifying the free or blocked portions of pipes

Abstract

The present invention relates to a polystyrene sulfonate metal salt, a production method thereof, and a composition including same, and more specifically, to a polystyrene sulfonate metal salt represented by formula 1, a production method thereof, and a composition including same.

IPC Classes  ?

• C08F 12/30 - Sulfur
• C08F 8/42 - Introducing metal atoms or metal-containing groups
• C08L 25/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen

Abstract

The present invention relates to a composition comprising a polystyrene sulfonic acid metal salt, a semiconductor device, and a method for manufacturing same, and more specifically, to a composition comprising: a polystyrene sulfonic acid metal salt; and an anionic polyelectrolyte, a semiconductor device comprising the composition, and a method for manufacturing same.

IPC Classes  ?

• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)
• H01L 51/56 - Processes or apparatus specially adapted for the manufacture or treatment of such devices or of parts thereof

Abstract

The present invention relates to a complex marker for diagnosing chronic liver disease on the basis of integrated transcriptome analysis and use thereof and, more specifically, to: 28 complex markers selected through integrated transcriptome analysis and machine learning analysis on patients with steatosis and non-alcoholic steatohepatitis; and a method for providing information for diagnosing chronic liver disease by using same. In the present invention, 28 genes co-selected from among: genes selected through differentially expressed gene (DEG) analysis by performing integrated transcriptome analysis on patients with steatosis and NASH; and genes selected using a feature selection process, were finally selected, and it was confirmed that, when 28 complex markers or an ATPase phospholipid transporting 8B1 (ATP8B1) marker was used, the ability to diagnose chronic liver disease was significantly improved. Thus, the complex marker of the present invention has been confirmed to be applicable as a biomarker for diagnosing chronic liver disease.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Disclosed are a method for preparing an active material, the surface of which is modified, using a surface treatment solution and an active material prepared thereby, and more particularly, an active material in which the amount of impurities on the surface thereof is reduced and on the surface of which a metal oxide configured to cut off direct contact with an electrolyte is uniformly disposed by collectively performing both a washing process and a surface treatment process using a surface treatment solution having a novel composition.

IPC Classes  ?

• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

The present invention relates to a method for manufacturing a magnetoelectrical laminate having a porous magnetostrictive electrode stacked thereon, the method comprising the steps of: preparing a piezoelectric layer made of a piezoelectric material; preparing a porous magnetostrictive layer having magnetostriction; manufacturing a magnetoelectrical laminate by stacking a porous magnetostrictive layer on the piezoelectric layer, and applying heat and pressure to the magnetoelectrical laminate; and polarizing the magnetoelectrical laminate. The present invention relates to a magnetoelectrical laminate having a porous magnetostrictive electrode stacked thereon, the magnetoelectrical laminate comprising: a piezoelectric layer made of a piezoelectric material; and a porous magnetostrictive layer having a plurality of pores formed therein and stacked on at least one surface of the piezoelectric layer to be inserted into the piezoelectric layer to a predetermined depth, wherein the piezoelectric layer is filled in the pores as the porous magnetostrictive layer is inserted into the piezoelectric layer to the predetermined depth.

IPC Classes  ?

• H01L 41/47 - Processes or apparatus specially adapted for the assembly, manufacture or treatment of magnetostrictive devices or of parts thereof
• H01L 41/12 - Magnetostrictive elements
• H01L 41/083 - Piezo-electric or electrostrictive elements having a stacked or multilayer structure
• H01L 41/277 - Manufacturing multilayered piezo-electric or electrostrictive devices or parts thereof, e.g. by stacking piezo-electric bodies and electrodes by stacking bulk piezo-electric or electrostrictive bodies and electrodes

Abstract

The present invention relates to a magnetoelectricity-based fine dust filter comprising: a nanofiber web made of piezoelectric nanofibers and polarized by applying an electric field; and magnetostrictive particles dispersed inside the nanofibers. The present invention relates to a method for manufacturing a magnetoelectricity-based fine dust filter, comprising the steps of: preparing magnetostrictive particles; dissolving a piezoelectric material in a solvent to prepare a piezoelectric material solution; mixing the magnetostrictive particles with the piezoelectric material solution to disperse the magnetostrictive particles in the piezoelectric material solution; spinning the piezoelectric material solution by an electrospinning method to prepare a nanofiber web made of nanofibers having piezoelectricity; and applying an electric field to the nanofiber web to polarize the nanofiber web.

IPC Classes  ?

• B03C 3/45 - Collecting-electrodes
• B03C 3/64 - Use of special materials other than liquids synthetic resins
• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres

Abstract

The present disclosure relates to a method for measuring a water level by using a UAV and virtual water control points and a method for generating 3D water surface spatial information, and a UAV used therefor. According to an embodiment, an UAV for a water surface survey includes: a position measurement unit configured to receive a GPS signal and to obtain position information of the UAV; a distance measurement unit including a plurality of laser measurement devices configured to project lasers toward the water surface; and a controller configured to calculate a moving distance of the UAV, based on measurement values of the position measurement unit and the distance measurement unit.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• G01F 23/292 - Light
• B64U 101/30 - UAVs specially adapted for particular uses or applications for imaging, photography or videography

Abstract

The present invention relates to an unmanned aerial vehicle for water surface observation. In an embodiment, provided is an unmanned aerial vehicle for water surface observation, the unmanned aerial vehicle comprising: a location measurement unit which receives a GPS signal to acquire location information of the unmanned aerial vehicle; a distance measurement unit having a plurality of lasers radiated toward a water surface; and a control unit which calculates a movement distance of the unmanned aerial vehicle on the basis of measurement values of the location measurement unit and the distance measurement unit.

IPC Classes  ?

• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• B64D 47/00 - Equipment not otherwise provided for
• B64D 45/00 - Aircraft indicators or protectors not otherwise provided for
• G01F 23/292 - Light
• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal
• G01C 11/02 - Picture-taking arrangements specially adapted for photogrammetry or photographic surveying, e.g. controlling overlapping of pictures
• G01S 19/01 - Satellite radio beacon positioning systems transmitting time-stamped messages, e.g. GPS [Global Positioning System], GLONASS [Global Orbiting Navigation Satellite System] or GALILEO

Abstract

Disclosed is an image sensor having a plurality of groups of pixels, each group of pixels including: first to third image detection color filter sets and a phase difference detection color filter set, which are arranged in a matrix with rows and columns. The phase difference detection color filter set comprises first to fourth phase difference detection color filter pairs arranged in a matrix with rows and columns. The first to fourth phase difference detection color filter pairs comprise first to fourth left phase difference detection color filters positioned on the left of each of the first to fourth phase difference detection color filter pairs and first to fourth right phase difference detection color filters positioned on the right of each of the first to fourth phase difference detection color filter pairs, respectively.

IPC Classes  ?

• H01L 27/146 - Imager structures
• H10K 59/60 - OLEDs integrated with inorganic light-sensitive elements, e.g. with inorganic solar cells or inorganic photodiodes

Abstract

The present invention relates to a multilayer copper foil, a method for manufacturing same, and an electroplating apparatus therefor. A multilayer copper foil according to an aspect of the present invention comprises: a recrystallization active layer which is formed by electroplating a plating solution containing copper ions on the surface of a substrate; and a recrystallization suppressing layer which consists of the same composition as the recrystallization active layer, is laminated and formed on the surface of the recrystallization active layer by the plating solution, and suppresses recrystallization of the recrystallization active layer.

IPC Classes  ?

• C25D 5/10 - Electroplating with more than one layer of the same or of different metals
• C25D 21/12 - Process control or regulation
• C25D 3/38 - ElectroplatingBaths therefor from solutions of copper
• C25D 5/00 - Electroplating characterised by the processPretreatment or after-treatment of workpieces
• C25D 7/06 - WiresStripsFoils
• C25D 1/04 - WiresStripsFoils

Abstract

The present invention relates to an anticancer adjuvant for treating anticancer-agent-resistant cancer, and a pharmaceutical composition containing same. If resistance to DNA replication inhibitory anticancer agents is exhibited, a substance for inhibiting the activity of tristetraprolin can be included as an anticancer adjuvant so as to maximize the effects of an anticancer agent, and thus is usable in cancer treatment. In addition, the present invention relates to a composition, a kit and a method for diagnosing resistance to DNA replication inhibitory anticancer agents, and the resistance to the anticancer agents can be identified by measuring the expression level of tristetraprolin.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61K 33/243 - PlatinumCompounds thereof
• A61P 35/00 - Antineoplastic agents
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A porous silicon manufacturing method according to the present invention comprises the steps of: pretreating a silicon precursor and a heat dispersant; and conducting a thermal reduction reaction between the heat dispersant-pretreated silicon precursor and a metal reducing agent by using a rotary reaction chamber. When porous silicon manufactured by the manufacturing method is contained in a secondary battery anode active material and used in secondary batteries, the batteries exhibit high capacity and long lifespan characteristics. The present invention relates to a method for manufacturing porous silicon and a method for manufacturing a secondary battery anode active material containing the porous silicon manufactured thereby, with the aim of solving the problems with silicon materials under development for anode active materials for lithium secondary batteries, including excessive volume expansion during charge/discharge and resultant electrode fracture and lifespan shortening.

IPC Classes  ?

• C01B 33/023 - Preparation by reduction of silica or silica-containing material
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals

Abstract

FlavobacteriumFlavobacterium sp. Strain TCH3-2 having accession number KACC81154BP can enhance the tolerance of plants to high-temperature or dry stress, and thus is expected to significantly contribute to improving crop productivity.

IPC Classes  ?

• A01N 63/20 - BacteriaSubstances produced thereby or obtained therefrom
• C12N 1/20 - BacteriaCulture media therefor
• A01H 1/06 - Processes for producing mutations, e.g. treatment with chemicals or with radiation
• A01H 5/10 - Seeds
• C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
• C12R 1/20 - Flavobacterium

Abstract

FlavobacteriumFlavobacterium sp. TCH3-2 strain can promote the production of pea and tobacco crops by remarkably increasing resistance to bean brown stem rot and tobacco mosaic disease.

IPC Classes  ?

• A01N 63/20 - BacteriaSubstances produced thereby or obtained therefrom
• C12N 1/20 - BacteriaCulture media therefor
• C12R 1/20 - Flavobacterium

Abstract

The present invention relates to an AFPM generator for a wind power generation apparatus, and to an AFPM generator for a wind power generation apparatus, the generator having blades formed at a rotor so as to enable cooling efficiency to be improved through forced convection inside the wind power generation apparatus. An AFPM generator for a wind power generation apparatus, according to a preferred embodiment of the present invention, comprises: a rotor (2) which is formed as a disk inside a housing (1), and which has permanent magnets (23) arranged in the circumferential direction on both side surfaces thereof; a first stator (31) provided on one side facing the rotor (2); a second stator (32) provided on the other side facing the rotor; and a shaft (4) passing through the center of the rotor, and thus being mounted so as to be rotatable together with the rotor (2), wherein the rotor (2) can have a plurality of blades (24) formed along the edge thereof.

IPC Classes  ?

• F03D 80/60 - Cooling or heating of wind motors
• F03D 1/06 - Rotors
• F03D 1/02 - Wind motors with rotation axis substantially parallel to the air flow entering the rotor having a plurality of rotors

Abstract

A cooling system applied to a hybrid-type multi-stage offshore wind power generation system, according to an embodiment of the present invention, comprises: a hybrid generator in which an axial flux permanent magnet (AFPM) is stacked in two stages and a radial flux permanent magnet (RFPM) is inserted into a hollow part; an air-cooled cooling system (10) in which a first flow path discharges external air introduced through a first inlet (100) provided at one side of an AFPM generator, to outlets (130) provided in a housing, and external air introduced into a second inlet (110) provided on one side of a RFPM generator passes through the inside of the RFPM generator and through guide flow passages (120) that communicate with the inside of the AFPM generator, and is discharged to the outlets (130); and a water-cooled cooling system (20) in which a heat pipe is provided using a predetermined n-pole stator as one module, and a module provided with the heat pipe is provided in a stator of the AFPM generator in a number that is m times the number of modules provided with the heat pipe in a stator of the RFPM generator. Here, the air-cooled cooling system (10) and the water-cooled cooling system (20) can be selectively or simultaneously driven.

IPC Classes  ?

• F03D 80/60 - Cooling or heating of wind motors

Abstract

The present invention relates to a spool valve in which the operating force can be reduced at high pressure, it is easy to switch a flow path or regulate flow rate, and maintenance and management are convenient. A spool valve according to one aspect of the present invention may comprise: a valve body provided with an input port through which a fluid flows in, a plurality of output ports through which the fluid is discharged, and a cylindrical valve chamber which communicates with the input port and the output ports; a ball-shaped valve member which is installed inside the valve chamber so as to be slidable, and has an inlet formed open at one end thereof and communicating with the input port, and an outlet formed open and selectively communicating with the plurality of output ports, such that the fluid that flows in through the inlet is discharged through the outlet; and a valve driving part for switching the flow path by sliding the valve member in an axial direction of the valve chamber.

IPC Classes  ?

• F16K 11/07 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with linearly sliding closure members with cylindrical slides
• F16K 3/316 - Guiding of the slide
• F16K 3/32 - Means for additional adjustment of the rate of flow
• F16K 31/06 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a magnet

Abstract

The present invention relates to a three-dimensional object using 3D printing and a manufacturing method therefor, wherein a desired pattern is produced in a flat shape by applying a 3D printing technology and then the desired pattern is easily formed into a desired three-dimensional shape by using a mold, and thus, a support is not required for producing a three-dimensional object and a three-dimensional object with various textile patterns can be simply and easily produced. The method for manufacturing a three-dimensional object using 3D printing according to the present invention may comprise the steps of: (S1) inputting pattern information of a pattern sheet to a 3D printer; (S2) mounting a base sheet on a working bed of the 3D printer; (S3) forming a pattern sheet in a flat shape having a predetermined pattern by outputting a thermoplastic resin filament onto the base sheet according to the pattern information input to the 3D printer; (S4) placing, on a mold having a three-dimensional shape, a composite of the pattern sheet output and bonded onto the base sheet and heating the composite to a predetermined temperature range to form the composite of the base sheet and the pattern sheet into a three-dimensional shape corresponding to the mold; and (S5) manufacturing the composite into a three-dimensional object having a final three-dimensional shape by finishing the border of the composite of the base sheet and the pattern sheet, the composite being formed into the shape corresponding to the three-dimensional shape of the mold.

IPC Classes  ?

• A43B 23/04 - Uppers made of one pieceUppers with inserted gussets
• A43B 23/02 - UppersBoot legs
• B29C 64/10 - Processes of additive manufacturing
• B29D 35/14 - Multilayered parts
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

Disclosed is a built-in type electric driving system of a machine tool. The system is capable of directly connecting a motor, which drives a spindle in a lathe which processes a workpiece, to an outer surface of the spindle without using a belt to rotate the spindle, and is capable of selectively transferring the power of the motor to a rotation system including a drawbar and a spindle for driving a chuck using a clutch device.

IPC Classes  ?

• B23Q 5/10 - Driving main working members rotary shafts, e.g. working-spindles driven essentially by electrical means
• B23Q 5/56 - Preventing backlash
• B23B 31/107 - Retention by laterally-acting detents, e.g. pins, screws, wedgesRetention by loose elements, e.g. balls

Abstract

A method of designing an optimized seawater pumping apparatus, using a computer in a system in which a seawater pumping apparatus including a pumping pipe and a well disposed to surround a lateral surface of a land-buried portion of the pumping pipe is installed to reduce seawater intrusion in a land in which an aquifer with a seawater-fresh water boundary surface is formed, includes applying an optimization algorithm to initial condition data of the aquifer to generate n decision variable sets of the seawater pumping apparatus, applying an underground water flow model to each of the n decision variable sets to generate n prediction results of change in the seawater-fresh water boundary surface, calculating a performance evaluation value of each of the n prediction results, and selecting a decision variable set having a maximum performance evaluation value, where n is an integer and equal to or greater than 2.

IPC Classes  ?

• E03B 3/11 - Obtaining and confining water by means of wells by means of pit wells in combination with tubes, e.g. perforated, extending horizontally, or upwardly inclined, exterior to the pits
• E02B 1/00 - Equipment or apparatus for, or methods of, general hydraulic engineering
• E03B 3/15 - Keeping wells in good condition, e.g. by cleaning, repairing, regeneratingMaintaining or enlarging the capacity of wells or water-bearing layers
• G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
• E02D 19/10 - Restraining of underground water by lowering level of ground water

Abstract

Disclosed is a non-powered seawater pumping apparatus for reducing seawater intrusion in a land in which an aquifer with a seawater-fresh water boundary surface is formed. The seawater pumping apparatus includes a pumping pipe having two open end portions, a first end portion of the open end portions being positioned below a sea level and a second end portion being positioned below the seawater-fresh water boundary surface in the land, and a well disposed to surround a lateral surface of a land-buried portion of the pumping pipe, which is buried in the land, so as to space away the land-buried portion of the pumping pipe from the land. The pumping pipe is filled with seawater, and the well comprises a screen having a plurality of through holes formed along a circumference of the well at a lower end portion of the well.

IPC Classes  ?

• E03B 3/11 - Obtaining and confining water by means of wells by means of pit wells in combination with tubes, e.g. perforated, extending horizontally, or upwardly inclined, exterior to the pits
• E02B 1/00 - Equipment or apparatus for, or methods of, general hydraulic engineering
• E03B 3/15 - Keeping wells in good condition, e.g. by cleaning, repairing, regeneratingMaintaining or enlarging the capacity of wells or water-bearing layers
• G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
• E02D 19/10 - Restraining of underground water by lowering level of ground water

Abstract

The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing berberine as an active ingredient, wherein berberine promotes mitophagy activity, and thus can be effectively used in the treatment of diseases caused by mitochondrial dysfunction.

IPC Classes  ?

• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/483 - Physical analysis of biological material
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing palmatine as an active ingredient, wherein palmatine promotes mitophagy activity, and thus can be effectively used in the treatment of diseases caused by mitochondrial dysfunction.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/483 - Physical analysis of biological material
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

Disclosed is a positive active material for a rechargeable lithium battery including secondary particles of a nickel-based transition metal oxide composed of an inner portion and an outer portion, wherein the inner portion has a dense structure having a higher density than the outer portion, the secondary particles of the nickel-based transition metal oxide have a plurality of protruding portions on the surface thereof, and the positive active material has an area ratio of 25% to 30% occupied by the protruding portions calculated by Equation 1 based on a cross-section of the secondary particles of the nickel-based transition metal oxide.

IPC Classes  ?

• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/04 - Processes of manufacture in general
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

The present invention relates to a pharmaceutical composition and a health functional food contain exosomes derived from Schwann cells treated with cyclic adenosine-3', 5'-monophosphate (cAMP), thereby inhibiting the proliferation of Schwann cells so as to enable the prevention or treatment of peripheral neurodegenerative diseases.

IPC Classes  ?

• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a device and method for predicting productivity of a shale gas well in a transition flow region by using a machine learning technique and, more specifically, to a device and method for predicting productivity of a shale gas well in a transition flow region by using a machine learning technique, wherein a data-based artificial neural network model is generated to calculate future production of a shale gas well in a transition flow region, and future production behaviors and estimated ultimate recovery are calculated using a decline curve method on the basis of the calculated future production and existing production data of the shale gas well in the transition flow region, whereby accurate results can be derived with less error than conventional productivity prediction methods for shale gas wells.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

The present invention relates to a composition for cathode active material surface treatment, a method for preparing same, and a cathode active material surface-treated with same and, more specifically, to a composition for cathode active material surface treatment, a method for preparing same, and a cathode active material surface-treated with same, wherein the composition comprises titanium dioxide coated with an ion activator. Therefore, the surface treatment with the composition for surface treatment of the present invention can perform a process of coating titanium on a surface while reducing residual lithium.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• C01G 23/047 - Titanium dioxide
• H01G 11/46 - Metal oxides
• H01G 11/50 - Electrodes characterised by their material specially adapted for lithium-ion capacitors, e.g. for lithium-doping or for intercalation

Abstract

The present invention relates to a gas fracturing device using gas to increase the permeability of a rock, and a method for evaluating an increase in rock permeability using same and, more specifically, to a device which can gas-fracture a rock by using gas to increase the permeability of a rock, and a method for evaluating an increase in permeability using same, which are capable of precisely simulating actual in-situ stress and temperature conditions with respect to a cylindrical or hexahedron-shaped rock sample extracted from underground bedrock.

IPC Classes  ?

• G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
• G01N 1/28 - Preparing specimens for investigation

Abstract

The present invention provides antibodies which specifically bind to pancreatic adenocarcinoma upregulated factor (PAUF) protein and uses thereof.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Disclosed is a non-powered seawater pumping apparatus for reducing seawater intrusion in a land in which an aquifer with a seawater-fresh water boundary surface is formed, the apparatus including a pumping pipe having opposite open end portions, a first end portion of the opposite open end portions being positioned below a sea level and a second end portion being positioned below a seawater-fresh water boundary surface in the land, and a well disposed to surround a lateral surface of a land-buried portion of the pumping pipe, which is buried in the land, so as to space away the land-buried portion of the pipe from the land, wherein seawater is filled in the pumping pipe, and the well includes a screen having a plurality of through holes formed along a circumference of the well at a lower end portion of the well.

IPC Classes  ?

• E02D 19/10 - Restraining of underground water by lowering level of ground water
• E03B 3/11 - Obtaining and confining water by means of wells by means of pit wells in combination with tubes, e.g. perforated, extending horizontally, or upwardly inclined, exterior to the pits
• E02B 1/00 - Equipment or apparatus for, or methods of, general hydraulic engineering
• E03B 3/15 - Keeping wells in good condition, e.g. by cleaning, repairing, regeneratingMaintaining or enlarging the capacity of wells or water-bearing layers

Abstract

The present invention relates to a steel thermophysical heating furnace apparatus having a deformation measurement gauge penetration housing, wherein a deformation measurement gauge penetration housing which is inserted into a deformation gauge mounting hole is configured to prevent heat inside a heating furnace from being discharged to the outside, and a steel specimen is inserted into the heating furnace to apply heat to the steel specimen via the heating furnace, thereby enabling more accurate measurement of the thermophysical properties of the steel specimen, and the height of the heating furnace is easily adjusted by a separate fixing device.

IPC Classes  ?

• F27B 17/02 - Furnaces of a kind not covered by any of groups specially designed for laboratory use
• F27D 5/00 - Supports, screens or the like for the charge within the furnace
• G01N 25/20 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity

Abstract

An image sensor includes a pixel array in which auto-focus (AF) pixels and image capture pixels are arranged. Wherein at least one of the AF pixels comprises: a color filter layer; and first and second microlenses arranged over the color filter layer, and formed in a region of the at least one AF pixel in a widthwise direction of the color filter layer.

IPC Classes  ?

• H04N 5/374 - Addressed sensors, e.g. MOS or CMOS sensors
• G02B 7/09 - Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification adapted for automatic focusing or varying magnification
• H04N 5/232 - Devices for controlling television cameras, e.g. remote control
• H04M 1/02 - Constructional features of telephone sets
• G02B 5/20 - Filters

Abstract

9 light aromatic hydrocarbons having an increased BTX content with a high yield from the byproducts of oil refining and petrochemical processes, which contain polycyclic aromatic hydrocarbons such as naphthalene, alkylnaphthalene, etc., can be achieved by using a catalyst in which one or more metal selected from group VIII and one or more metal selected from group VIB are supported on a composite zeolite support of zeolite beta and zeolite ZSM-5.

IPC Classes  ?

• C07C 4/18 - Catalytic processes
• B01J 29/46 - Iron group metals or copper
• B01J 29/48 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11 containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
• B01J 29/76 - Iron group metals or copper
• B01J 29/78 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
• B01J 29/80 - Mixtures of different zeolites
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/08 - Heat treatment
• B01J 29/72 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing iron group metals, noble metals or copper
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts

Abstract

The present invention relates to a universal joint, for a propeller shaft, having an elastic damper. The same comprises: a driving yoke fixed to the rear end of a front shaft of a propeller shaft, the driving yoke having a through-hole arranged along a straight line; a following yoke provided on the front end of a rear shaft, the following yoke having a through-hole arranged along a straight line; a journal cross having a cross shape and having four trunnions fitted to the through-holes of the driving yoke and the following yoke, respectively; bearings surrounding and supporting respective trunnions; a bearing cap fixed to respective through-holes while containing the bearings and the trunnions therein; an upper damping member and a lower damping member installed inside the bearing cap so as to elastically support the trunnions and arranged to be spaced apart from and in parallel with each other inside the bearing cap; and an elastic support portion provided between the upper damping member and the lower damping member. The universal joint, for a propeller shaft, having an elastic damper according to the present invention, configured as above, has an elastic damper provided inside the bearing cap such that, by attenuating vibration generated by the propeller shaft, there is no noise resulting from resonance, that is, no vibration. In addition, the bearings are not damaged by vibration, even if used for a long period of time, such that the life of the propeller shaft can be extended accordingly.

IPC Classes  ?

• F16D 3/28 - Hooke's joints or other joints with an equivalent intermediate member to which each coupling part is pivotally or slideably connected in which the interconnecting pivots include elastic members

Abstract

The present invention relates to a built-in type electric driving system of a machine tool. The system may comprise: a housing; a hollow tube-shaped spindle extending in the forward/backward direction with respect to the housing and installed to be able to rotate with regard to the housing; a built-in motor comprising a stator fixed inside the housing and a rotor fixed to the outer surface of the spindle and generating a torque between the stator and the rotor by externally applied power to rotate the rotator; a chuck installed at the front end of the spindle and including a jaw for gripping an object to be processed; a drawbar installed inside the spindle to linearly move the forward/backward and having a front end connected to the jaw; a drawbar key and a drawbar key groove, which connect the drawbar to the chuck such that the drawbar can linearly move, but cannot rotationally move; a chuck locking unit for restricting or releasing a rotational movement of the chuck with regard to the housing; a clutch unit installed to move forward/backward between the front portion of the spindle and the rear portion of the chuck so as to restrict the spindle to the chuck or separate the spindle in a rotatable manner relative to the chuck; a leadscrew formed to be fixed to the drawbar and having a thread helically formed on the outer surface thereof; a driving unit fixed to the outer surface of the spindle so as to rotate together with the spindle; and a female screw cover coupled to the driving unit so as to rotate together with driving unit, and having a thread formed on the inner peripheral surface thereof so as to be screw-coupled to the thread of the leadscrew.

IPC Classes  ?

• B23Q 5/10 - Driving main working members rotary shafts, e.g. working-spindles driven essentially by electrical means
• B23Q 5/56 - Preventing backlash
• B23B 31/02 - Chucks
• B23Q 1/00 - Members which are comprised in the general build-up of a form of machine, particularly relatively large fixed members

Abstract

Disclosed is a functional game system and method for disaster handling. The present invention comprises: a disaster handling cloud server (corresponding to a disaster cloud server) for storing, in advance, at least one disaster handling scenario (corresponding to a disaster scenario) developed according to a disaster handling specialist's (master key user's) handling of a disaster situation of a ship, train or airplane; and a disaster handling specialist terminal for downloading a disaster handling scenario stored in the disaster handling cloud server, executing the downloaded scenario in virtual reality, receiving a countermeasure of the disaster handling specialist in response to a disaster situation in the executed disaster handling scenario, and developing the disaster handling scenario according to the received countermeasure.

IPC Classes  ?

• G06Q 50/26 - Government or public services
• G06Q 50/10 - Services

Abstract

FlavobacteriaceaeFlavobacteriaceae strain comprising the 16S rRNA of SEQ ID NO: 1 and having the effects of controlling plant diseases including bacterial wilt and promoting plant growth.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A01N 63/02 - Substances produced by, or obtained from, microorganisms or animals
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The present invention relates to a device for screening senescence, and more particularly, to a device for screening senescence, wherein body function information is collected as objectively as possible from information about a subject of determination, and senescence of the subject of determination is determined on the basis of basic body information and the body function information to enhance determination reliability. The subject matter of the present invention is a device for screening senescence characterized by including: a body function information collecting unit for collecting each of grip power information, walking speed information, weight change information, vitality information, and body activity information about the subject of determination; a basic body information collecting unit for collecting each of age information, gender information, height information, and weight information on the subject of determination; and a senescence determining unit for determining senescence by classifying the subject as being one among normal, pre-senescent, and senescent, on the basis of the grip power information, the walking speed information, the weight change information, the vitality information, the body activity information, the age information, the gender information, the height information, and the weight information collected by the body function information collecting unit and the basic body information collecting unit.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/22 - ErgometryMeasuring muscular strength or the force of a muscular blow
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Abstract

The present invention relates to a flow control valve. The flow control valve comprises: a casing having an inlet and an outlet which are open in opposite directions and allow the passage of a fluid, and closed chambers which are provided between the inlet and the outlet and face each other at a distance from each other; a pair of disk pieces, each having a semicircular shape, which stand by while being accommodated in the respective closed chambers and, upon operation, move into a flow path between the inlet and the outlet and join each other, thereby blocking the flow of the fluid; a pair of rotary arms which are fixed to the respective disk pieces and extended to the outside of the casing and intersect with each other; a center pin which is installed in the area of the intersection of the rotary arms and serves the role of a rotation shaft when the rotary arms perform a crossing motion; and a drive part which is connected to extended end parts of the rotary arms and allows the rotary arms to perform the crossing motion, such that the disk pieces join each other and take on the shape of a circular disk, or are separated from each other and retract to the closed chambers.

IPC Classes  ?

• F16K 3/04 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing facesPackings therefor with pivoted closure members
• F16K 3/02 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing facesPackings therefor
• F16K 3/314 - Forms or constructions of slidesAttachment of the slide to the spindle
• F16K 31/122 - Operating meansReleasing devices actuated by fluid the fluid acting on a piston

Abstract

The present invention relates to a method for producing a porous silicon-carbon complex, a secondary battery negative electrode material produced by the production method, and a secondary battery comprising the secondary battery negative electrode material. The method for producing a porous silicon-carbon complex according to an embodiment of the present invention comprises: a step of mixing a silicon precursor with a heat dispersant and subjecting the mixture to first heat treatment, thereby producing a first mixture; a step of mixing the first mixture with a metal reducing agent, thereby producing a second mixture; a step of putting the second mixture into a reaction chamber and subjecting same to second heat treatment, thereby reducing the silicon precursor and producing a reaction product; a step of washing the reaction product and collecting porous silicon particles; a step of mixing the porous silicon particles with a carbon precursor, thereby producing a third mixture; and a step of subjecting the third mixture to third heat treatment, thereby coating the porous silicon particles with carbon.

IPC Classes  ?

• C01B 33/021 - Preparation
• C01B 32/05 - Preparation or purification of carbon not covered by groups , , ,
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

The present invention relates to an antibody specifically binding to a pancreatic adenocarcinoma upregulated factor (PAUF) protein, and a use thereof. The antibody of the present invention binds to the PAUF protein with high specificity and affinity and inhibits the proliferation, migration, penetration and in vivo growth of cancer cells, thereby being effectively used in the field of diagnosis and treatment of diseases, such as cancer, in which the PAUF protein is overexpressed.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

in vivoin vivo growth of cancer cells, thereby being effectively used in the field of diagnosis and treatment of diseases, such as cancer, in which the PAUF protein is overexpressed.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

in vivoin vivo growth of cancer cells, thereby being effectively used in the field of diagnosis and treatment of diseases, such as cancer, in which the PAUF protein is overexpressed.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a smart evacuation guidance system and method which use augmented reality and a context awareness algorithm, the system and the method immediately installing a smart evacuation guidance application on a disaster evacuee terminal by using an NFC-based evacuation guidance tag or a LoRa-based evacuation guidance sensor provided in a building or the like, such that an evacuation guidance path is displayed on a display of the disaster evacuee terminal in an augmented reality manner, thereby ensuring a prompt and safe evacuation route for a disaster evacuee and allowing anyone to easily evacuate.

IPC Classes  ?

• G08B 21/10 - Alarms for ensuring the safety of persons responsive to calamitous events, e.g. tornados or earthquakes
• G08B 25/14 - Central alarm receiver or annunciator arrangements
• G08B 25/10 - Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems characterised by the transmission medium using wireless transmission systems
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
• G08B 5/22 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmissionVisible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission
• G06T 19/00 - Manipulating 3D models or images for computer graphics