Described herein are reagent loading devices configured to simultaneously deliver one or more test agents (e.g., antibiotics) to a sample such as a bacterial culture without having to individually deliver the test agents. These devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics. Also described herein are kits and systems for chemical or biological assays.
The present disclosure provides methods of treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of peramivir, cidofovir, or nevirapine and an effective amount of a second antiviral agent. Also provided are methods of treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of nevirapine and an effective amount of valacyclovir and/or nevirapine. Also provided are formulations and methods of delivering the formulations to an individual.
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 31/708 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/665 - Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
Described herein are reinforced gas-permeable cell culture apparatus that allows for gas exchange without disturbing the cell culture, including cell cultures in a fully closed culture system. Also described are kits/systems comprising same and methods of using same.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
C12M 1/00 - Apparatus for enzymology or microbiology
Described herein are reagent loading devices configured to simultaneously deliver one or more test agents (e.g., antibiotics) to a sample such as a bacterial culture without having to individually deliver the test agents. These devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics. Also described herein are kits and systems for chemical or biological assays.
The transfer systems, devices, kits, and methods described here may be used to facilitate the transfer of a material (e.g., a fluid) to or from a donor container, e.g., to or from wells of a donor plate while leaving target agents attached to the wells. The systems may comprise a donor plate, a transfer adapter, and a receiver plate that may be coupled to form a transfer assembly. The transfer adapter may comprise a planar sheet and a plurality of openings, and it may be configured to regulate the flow of fluid out of the wells. The transfer assembly may be placed into a centrifuge, and the fluid transfer force produced by the centrifuge may cause fluid to flow out of the wells of the donor plate, through the openings in the transfer adapter, and into the receiver plate.
The present disclosure provides methods of treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of peramivir and a second antiviral agent. Also provided are formulations and methods of delivering the formulations to an individual.
The present disclosure provides methods of treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of cidofovir and a second antiviral agent. Also provided are formulations and methods of delivering the formulations to an individual.
The present disclosure provides methods of treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of nevirapine and an effective amount of valacyclovir and/or nevirapine. Also provided are formulations and methods of delivering the formulations to an individual.
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Described herein are multi-well separation devices configured to allow a composition comprising a target agent to be separated into multiple wells, subdivided, recombined into a single well, and/or re-separated into the same or a different configuration of wells. Also described herein are reagent loading devices configured to simultaneously deliver one or more test agents to a plurality of volumes without having to individually deliver the test agents. Together, these devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics, though they may also be used separately. Also described herein are kits and systems for chemical or biological assays, as well as methods for using the multi-well separation devices and reagent loading devices described herein.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B01F 31/441 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
B01F 31/85 - Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
B01F 101/23 - Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
10.
MATERIAL TRANSFER DEVICE AND METHOD OF USE THEREOF
The transfer systems, devices, kits, and methods described here may be used to facilitate the transfer of a material (e.g., a fluid) to or from a donor container, e.g., to or from wells of a donor plate while leaving target agents attached to the wells. The systems may comprise a donor plate, a transfer adapter, and a receiver plate that may be coupled to form a transfer assembly. The transfer adapter may comprise a planar sheet and a plurality of openings, and it may be configured to regulate the flow of fluid out of the wells. The transfer assembly may be placed into a centrifuge, and the fluid transfer force produced by the centrifuge may cause fluid to flow out of the wells of the donor plate, through the openings in the transfer adapter, and into the receiver plate.
Described herein are multi-well separation devices configured to allow a composition comprising a target agent to be separated into multiple wells, subdivided, recombined into a single well, and/or re-separated into the same or a different configuration of wells. Also described herein are reagent loading devices configured to simultaneously deliver one or more test agents to a plurality of volumes without having to individually deliver the test agents. Together, these devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics, though they may also be used separately. Also described herein are kits and systems for chemical or biological assays, as well as methods for using the multi-well separation devices and reagent loading devices described herein.
Described herein are multi-well separation devices configured to allow a composition comprising a target agent to be separated into multiple wells, subdivided, recombined into a single well, and/or re-separated into the same or a different configuration of wells. Also described herein are reagent loading devices configured to simultaneously deliver one or more test agents to a plurality of volumes without having to individually deliver the test agents. Together, these devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics, though they may also be used separately. Also described herein are kits and systems for chemical or biological assays, as well as methods for using the multi-well separation devices and reagent loading devices described herein.
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