A method of controlling the output of an electrokinetic pump includes: (1) measuring an initial pressure in an electrokinetic pump system; (2) applying a pump drive signal to the electrokinetic pump to begin a pump stroke; (3) measuring the pressure after a predetermined time of applying the pump drive signal; (4) identifying when the pressure has returned to the initial pressure plus a constant; and (5) stopping the pump drive signal to complete the stroke.
A reciprocating electrokinetic pump system includes a buffer reservoir to automatically refill the buffer in the system. Also described is a wound treatment system that can include the reciprocating EK pump system and/or that can provide accurately monitored negative pressure wound therapy, such as with a pressure sensor attached directly to the wound patch.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
3.
ELECTROKINETIC PUMP BASED WOUND TREATMENT SYSTEM AND METHODS
A wound treatment system includes a patch, first and second fluid reservoirs, an electrokinetic pump assembly, and a controller. The patch is configured to enclose a wound area and includes an inlet and an outlet. The first fluid reservoir is fluidically connected to the inlet and the second fluid reservoir is fluidically connected to the outlet. The electrokinetic pump assembly is configured to pump a first treatment fluid from the first fluid reservoir into the patch through the inlet and to pump fluid from the patch through the outlet and into the second fluid reservoir. The controller is configured to operate the electrokinetic pump assembly and to include an electronic memory containing computer readable instructions for operating the electrokinetic pump assembly to perform a wound therapy protocol in the wound area.
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A61F 15/00 - Auxiliary appliances for wound dressingsDispensing containers for dressings or bandages
A method of controlling the output of an electrokinetic pump to deliver a target stroke volume includes applying a pump drive signal to the electrokinetic pump for a pump stroke time duration and then determining a volume of a delivery fluid pumped. Then, comparing the volume of the delivery fluid pumped to the target stroke volume; generate a new time interval for applying the pump drive signal. Then apply the pump drive signal to the electrokinetic pump for the new time interval. A system for delivery of fluid includes an electrokinetic pump under the control of an electronic controller. The electronic controller contains computer readable instructions to determine an output of the electrokinetic pump and then generate a stroke time delivery adjustment for precise pumping schemes.
F04B 23/02 - Pumping installations or systems having reservoirs
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
A fluid delivery system includes a first chamber, a second chamber, and a third chamber, a pair of electrodes, a porous dielectric material, an electrokinetic fluid, and a flexible member including a gel between two diaphragms. The pair of electrodes is between the first chamber and the second chamber. The porous dielectric material is between the electrodes. The electrokinetic fluid is configured to flow through the porous dielectric material between the first and second chambers when a voltage is applied across the pair of electrodes. The flexible member fluidically separates the second chamber from the third chamber and is configured to deform into the third chamber when the electrokinetic fluid flows form the first chamber into the second chamber.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
An electrokinetic system includes a first electrokinetic pump, a second electrokinetic pump, a reservoir having delivery fluid therein, and a controller. The first electrokinetic pump is configured to provide a first range of flow rates. The second electrokinetic pump is configured to provide a second range of flow rates. The second range includes flow rates that are greater than the flow rates of the first range. The reservoir is fluidically attached to the first electrokinetic pump and the second electrokinetic pump. The controller is configured to apply voltage to one of the first or second electrokinetic pumps and then apply voltage to the other of the first or second electrokinetic pumps so as to vary the flow rate range of delivery fluid pump from the reservoir.
A microfluidic processing system having a manifold with at least one inlet; at least one outlet; and a plurality of microfluidic chip holders. A fluidic jumper is coupled to one of the chip holders and at least two fluidic elements are coupled to at least one of the chip holders. The fluidic jumper controls the fluidic path through the system.
An electrokinetic pump and fluid delivery system is provided that may include any of a number of features. One feature of the fluid delivery system is that it can deliver a fixed volume of fluid with each stroke of the electrokinetic pump. Another feature of the fluid delivery system is that it can accurately deliver fluid at a target flow rate over time. Methods associated with use of the electrokinetic pump and fluid delivery system are also covered.
F04B 37/02 - Pumps specially adapted for elastic fluids and having pertinent characteristics not provided for in, or of interest apart from, groups for evacuating by absorption or adsorption
9.
METHODS, COMPOSITIONS AND DEVICES, INCLUDING ELECTROOSMOTIC PUMPS, COMPRISING COATED POROUS SURFACES
Methods are disclosed for modifying at least a portion of a porous polymeric surface. Such methods include contacting the porous polymeric surface with at least one polyelectrolyte, resulting in the physical adsorption of at least one polyelectrolyte onto the porous polymeric surface to form a charge modified surface. Such coated surfaces may be part of a device or apparatus, including electroosmotic pumps.
An electrochemical cell 100 for processing a sample fluid, has a body 102 with a flow path 106, the flow path having an inlet 110 and an outlet 112; a reference electrode 122, 144 in fluid communication with the flow path; a counter electrode 124, 146 in fluid communication with the flow path; a porous working electrode 128 in fluid communication with the flow path, the working electrode having a working electrode material; an electrical connection 126 for the working electrode in electrical contact with the working electrode; and a working electrode section 132 in the flow path. The working electrode is positioned inside the working electrode section. The working electrode section has a volume of from about 1 pL to about 1 쎽L.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
11.
ELECTROKINETIC PUMP DESIGNS AND DRUG DELIVERY SYSTEMS
One embodiment of the present invention provides a piston assembly having a piston housing filled with an electrolyte; a housing within the piston housing that divides the piston housing into a first portion and a second portion, the housing having apertures, a shaft connecting the housing to a piston head outside of the piston housing; and a porous material inside of the housing in contact with the electrolyte. Additionally, there are provided a method for filling the delivery chamber with a delivery fluid by withdrawing the piston head from within the delivery chamber. Yet another embodiment provides a method for filling a fluid delivery assembly by withdrawing a shaft from within the fluid delivery assembly to simultaneously displace a moving pump element within the delivery chamber and bypass fluid around a housing in the pump chamber.
F04B 37/02 - Pumps specially adapted for elastic fluids and having pertinent characteristics not provided for in, or of interest apart from, groups for evacuating by absorption or adsorption
F04B 17/00 - Pumps characterised by combination with, or adaptation to, specific driving engines or motors
patents