Abstract

The present disclosure concerns an extruded biodegradable material for aquaculture, which comprises at least one biodegradable polymer and at least one functional additive. The production method of the biodegradable material, as well as articles comprising said material, are also disclosed. An aspect of the present invention comprises an extruder for obtaining the extruded biodegradable material.

IPC Classes  ?

• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish
• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
• B29C 48/05 - Filamentary, e.g. strands
• B29C 48/30 - Extrusion nozzles or dies
• B29C 48/68 - Barrels or cylinders
• B29K 67/00 - Use of polyesters as moulding material
• B29K 105/00 - Condition, form or state of moulded material
• C02F 1/00 - Treatment of water, waste water, or sewage
• C02F 103/20 - Nature of the water, waste water, sewage or sludge to be treated from animal husbandry

Abstract

The invention refers to a biosensor device for assessing responses to pesticide applications in soils, comprising a vessel (1) with closed walls (2), a lid (3) with a first set of meshes (5), a cover (4) with a second set of meshes (6), a portion of a sample soil (7), and earthworms (8) held inside said biosensor device. The invention also refers to a method for assessing responses to pesticide applications in soils, which uses said biosensor device. The biosensor device for the field exposure of earthworms can be easily produced and become available to farmers for being applied in the field, before phytosanitary treatments and, collected afterward to be sent for the analysis of different molecular biomarkers referred to earthworms. The biosensor device assures that earthworms be exposed to pesticides while preventing the organisms from escaping.

IPC Classes  ?

• G01N 33/24 - Earth materials
• G01N 33/483 - Physical analysis of biological material

Abstract

The present invention refers to a genetic construct for carrying a protein of interest in cyanobacterial extracellular vesicles (EVs) of Synechocystis sp. PCC6803. The present invention further relates to the derived transformed Synechocystis strain comprising the said construct. Cyanobacterium transformed with referred construct are, most surprisingly, further characterized by hypervesiculating EVs to larger extents than the wild-type and mutant strains known in the art. Cyanobacterium transformed with the referred construct secrete the protein of interest in EVs and to the extracellular medium thus, the present invention also refers to compositions comprising EVs derived from the said transformed Synechocystis strain, as well as compositions comprising the EV-free extracellular medium derived from the said transformed Synechocystis strain, for use in carrying proteins proteins/enzymes into animals, including mammals and fish. The present invention further refers to methods for transforming mammalian epithelial cells with EVs isolated from the said Synechocystis strain, which internalize the said EVs and display the protein of interest. Moreover, the present invention refers to methods by which cyanobacterial EVs can work as nanocarriers of custom proteins into fish, with prospective applications in modulation of nutritional status or stimulating specific adaptive immune responses. The construct, strain, compositions uses and methods in the present invention may be advantageously employed as a novel biotechnological tool for the specific delivery of biologically active proteins and enzymes in biotechnology in general and in aquaculture in specific.

IPC Classes  ?

• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 35/748 - Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina

Abstract

The present invention relates to cationic steroid compounds of formula (I) and methods of obtaining them. The present invention further relates to the incorporation of such compounds in a polymeric matrix composition or a coating composition, as well as their use as antimicrobials.

IPC Classes  ?

• A61P 31/04 - Antibacterial agents
• A61P 31/10 - Antimycotics
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
• C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Abstract

Novel compounds able to absorb UV radiation and comprise antimicrobial properties as well. The compounds are novel and undisclosed scytonemin analogs, able to absorb up to 90% of UV-A radiation and can cover a broader UV to blue light absorption range from 293 nm to 500 nm. When mixtures of more than one compound are used, their synergetic absorption properties can cover an even broader spectrum within 293 nm to 500 nm. The compounds present faint coloration, and some are even colorless, therefor the present compounds can be easily incorporated in formulations to be used in cosmetic products, sunscreens or lenses for sunglasses.

IPC Classes  ?

• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
• G02B 5/00 - Optical elements other than lenses
• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses

Abstract

The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

IPC Classes  ?

• C07C 69/63 - Halogen-containing esters of saturated acids
• A61P 31/04 - Antibacterial agents
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present disclosure relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds, in particular it relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds having antibacterial activity and/or antimalarial activity.

IPC Classes  ?

• C07D 471/14 - Ortho-condensed systems
• C07D 487/04 - Ortho-condensed systems
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure relates to hydroxypheophorbide compounds with bioactivities towards obesity and obesity-related co-morbidities. Therefore, the present subject-matter discloses hydroxypheophorbide compounds or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide, stereoisomer, diastereoisomer, enantiomer or atropisomer, polymorph for use in medicine comprising formula (I), wherein R is CnH(2n-1) and n is an entire number multiple of 5. The compound of the present disclosure may be use in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders. The present disclosure relates to hydroxypheophorbide compounds with bioactivities towards obesity and obesity-related co-morbidities. Therefore, the present subject-matter discloses hydroxypheophorbide compounds or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide, stereoisomer, diastereoisomer, enantiomer or atropisomer, polymorph for use in medicine comprising formula (I), wherein R is CnH(2n-1) and n is an entire number multiple of 5. The compound of the present disclosure may be use in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders.

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• A61P 3/04 - AnorexiantsAntiobesity agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

Tenacibaculum maritimumTenacibaculum maritimum infections.

IPC Classes  ?

• A23J 1/06 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from blood
• A23J 3/12 - Animal proteins from blood
• A23J 3/30 - Working-up of proteins for foodstuffs by hydrolysis
• A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
• A23K 10/14 - Pretreatment of feeding-stuffs with enzymes
• A23K 10/24 - Animal feeding-stuffs from material of animal origin from blood
• A23K 20/147 - Polymeric derivatives, e.g. peptides or proteins
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 31/04 - Antibacterial agents
• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Abstract

The present disclosure relates to a portable device for collecting and/or concentrating in situ plankton microbiome, configured for submersion in water. The device herein disclosed is a compact and low-cost autonomous biosampler, with the ability to yield DNA samples for later genomic analysis.

IPC Classes  ?

• C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
• G01N 1/40 - Concentrating samples
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
• G01N 1/14 - Suction devices, e.g. pumpsEjector devices

Abstract

Synthetic small molecules from an important class of heterocyclic derivatives and homologs and their use as antifouling agents for protection against marine biofouling. The antifouling compounds disclosed herein are environmentally friendly and are able to reduce marine biofouling without inducing toxic effects to target and non-target species. The claimed antifouling compounds also possess ability to be incorporated as antifouling additives in polymeric formulations. Thus, allowing its further application for the preparation of antifouling polymeric matrices, such as coatings, with no hazard effects for the environment.

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C09D 5/16 - Anti-fouling paintsUnderwater paints

Abstract

The present disclosure relates to the isolation, identification and characterization of novel sporeforming probiotic strain(s) with NSPase (Non-Starch Polysaccharides-active hydrolases) activity isolated from fish gut microbiota, methods and uses thereof. The sporeforming probiotic strain(s) with NSPase activity now disclosed are able of producing carbohydrate-active enzymes (CAZymes) that hydrolyse non-starch polysaccharides (NSPs) and accesses their potential as probiotics (PRO) for use in particular in aquafeeds.

IPC Classes  ?

• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
• A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
• C12N 1/20 - BacteriaCulture media therefor
• C12R 1/125 - Bacillus subtilis
• C12R 1/07 - Bacillus
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution

Abstract

The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

IPC Classes  ?

• C07C 69/63 - Halogen-containing esters of saturated acids
• A61K 31/23 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Abstract

bbb]quinazoline-3,6-diones compounds having antibacterial activity and/or antimalarial activity.

IPC Classes  ?

• C07D 471/14 - Ortho-condensed systems
• C07D 487/04 - Ortho-condensed systems
• C07D 487/14 - Ortho-condensed systems
• A61P 31/04 - Antibacterial agents
• A61P 33/06 - Antimalarials
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

The present disclosure relates to disrupting algae cell walls, in order to obtain protoplast with high nutrient digestibility for use as a food ingredient and/or as feed for farmed fish and shellfish species, which leads to the production of added value sea food items and to more sustainable and better performing food chains. The present disclosure described a method for obtaining proteins or a rich-protein extract from algae, comprising the steps of: disrupting a cell wall of algae by physical-mechanical means using a vibratory grinding mill with rings; submitting the disrupted algae to an enzymatic hydrolysis carried out with a mixture of enzymes; wherein the enzyme mixture is a mixture of at least two enzymes selected from the following list: lipase, pectinase, cellulase, hemicellullase, endo exo-arabanase, amylase, or mixtures thereof; provided that at least one of the enzymes is lipase, pectinase, amylase.

IPC Classes  ?

• A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
• A23J 1/00 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites
• A23J 3/20 - Proteins from microorganisms or unicellular algae
• A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
• A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions

Abstract

n2n-12n-1) and n is an entire number multiple of 5. The compound of the present disclosure may be use in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders.

IPC Classes  ?

• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61P 3/04 - AnorexiantsAntiobesity agents
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings

Abstract

The present application relates to synthetic small molecules from an important class of heterocyclic derivatives and homologs and their use as antifouling agents for protection against marine biofouling. The antifouling compounds disclosed herein are environmentally friendly and are able to reduce marine biofouling without inducing toxic effects to target and non-target species. The claimed antifouling compounds also possess ability to be incorporated as antifouling additives in polymeric formulations. Thus, allowing its further application for the preparation of antifouling polymeric matrices, such as coatings, with no hazard effects for the environment.

IPC Classes  ?

• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
• A01N 43/60 - 1,4-DiazinesHydrogenated 1,4-diazines
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• C09D 5/16 - Anti-fouling paintsUnderwater paints

Abstract

in situin situ plankton microbiome, configured for submersion in water. The device herein disclosed is a compact and low-cost autonomous biosampler, with the ability to yield DNA samples for later genomic analysis.

IPC Classes  ?

• C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
• G01N 1/34 - PurifyingCleaning

Abstract

The present disclosure relates to the isolation, identification and characterization of novel sporeforming probiotic strain(s) with NSPase (Non-Starch Polysaccharides-active hydrolases) activity isolated from fish gut microbiota, methods and uses thereof. The sporeforming probiotic strain(s) with NSPase activity now disclosed are able of producing carbohydrate-active enzymes (CAZymes) that hydrolyse non-starch polysaccharides (NSPs) and accesses their potential as probiotics (PRO) for use in particular in aquafeeds.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs

Abstract

The present disclosure relates to disrupting algae cell walls, in order to obtain protoplast with high nutrient digestibility for use as a food ingredient and/or as feed for farmed fish and shellfish species, which leads to the production of added value sea food items and to more sustainable and better performing food chains. The present disclosure described a method for obtaining proteins or a rich-protein extract from algae, comprising the steps of: disrupting a cell wall of algae by physical-mechanical means using a vibratory grinding mill with rings; submitting the disrupted algae to an enzymatic hydrolysis carried out with a mixture of enzymes; wherein the enzyme mixture is a mixture of at least two enzymes selected from the following list: lipase, pectinase, cellulase, hemicellullase, endo exo-arabanase, amylase, or mixtures thereof; provided that at least one of the enzymes is lipase, pectinase, amylase.

IPC Classes  ?

• A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
• A23J 1/00 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites
• A23J 3/20 - Proteins from microorganisms or unicellular algae
• A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
• A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs

Abstract

Autonomous aquaculture fish feeding system comprising an autonomous vessel (2, 71) having a plurality of temperature and salinity sensors (72) for two or more predetermined pond water depth ranges; an electronic data processor (1) configured for calculating a fish weight prediction model from collected temperature and salinity data from said temperature and salinity sensors (72) from each predetermined pond water depth range; wherein said fish weight prediction model is segmented into one or more prediction model segments, optionally for each of the predetermined pond water depth ranges. The electronic data processor (1) may be configured for calculating the fish weight prediction model, for each prediction model segment, by: accumulating weight gained into an accumulated total weight, wherein the weight gained is calculated from the energy used at each prediction period, calculating the energy used from the accumulated total feeding intake; accumulating feeding intake into accumulated total feeding intake, wherein the feeding intake is calculated from the total weight, a temperature factor and a salinity factor.

IPC Classes  ?

• A01K 61/80 - Feeding devices
• A01K 61/95 - Sorting, grading, counting or marking live aquatic animals, e.g. sex determination specially adapted for fish