Abstract

Compositions and methods are provided in which a nutritional supplement that is utilized in the treatment viral infections (e.g., coronavirus, HCV, HIV), by correcting dysregulation of apoptosis, reducing production of pro-inflammatory cytokines, and increasing production of host anti-viral compounds. The nutritional supplement can be used in combination with known antiviral therapies, as well as low level radiotherapy and/or chemotherapy drugs conventionally used in the treatment of neoplastic disease.

IPC Classes  ?

• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61N 5/00 - Radiation therapy
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/18 - Antivirals for RNA viruses for HIV
• A61P 35/00 - Antineoplastic agents

Abstract

Compositions and methods are described in which a nutritional supplement (such as a supplement that includes chromium and certain plant-derived materials and/or a supplement that includes a selenium yeast peptide complex and fish oil is used to provide an immunotherapeutic effect, which can be demonstrated by modulation of cell-surface markers targeted by conventional immunotherapeutic drugs. The nutritional supplements can be used in combination with other antineoplastic therapies, such as radiation and/or chemotherapeutic agents. Such combination therapy can provide a synergistic effect in regard to modulation of cell surface markers that serve as immunotherapy targets.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61P 35/00 - Antineoplastic agents

Abstract

A nutritional supplement that includes fish oil and selenium has been found to provide a variety of activities beneficial in treating cancer and associated conditions. Such a supplement provides synergistic effects in reducing cancer cell proliferation when used in combination with chemotherapeutic drugs, and can reduce proliferation in drug-resistant cancer cells when used in combination with chemotherapeutic drugs to which the cells are resistant. Effects in reducing angiogenesis, reducing metastasis, reducing the number of circulating cancer cells, and modifying AXL signalling were also found. In addition, use of such a supplement was found to reduce wasting associated with cachexia and reduce circulating cytokines associated with inflammation. Overall effects were found to extend survival in clinical studies.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A nutritional supplement containing fish oil and selenium has been identified that potentiates radiotherapy of tumors in a synergistic fashion. Cotherapy with such a supplement and radiotherapy results in substantially improved reductions in tumor volume of animal models relative to radiotherapy alone, and reduces common side effects such as weight loss, inflammation, and damage to the gastrointestinal tract. Such cotherapy was also found to reduce the incidence of metastasis from the primary implantation site, and to modulate expression of genes associated with apoptosis in tumor cells. A formulation for such a supplement that is both well tolerated and palatable is also provided.

IPC Classes  ?

• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61P 35/00 - Antineoplastic agents

Abstract

A method for decreasing proliferation of cancer cells comprises the steps of administering a sensitizer. Sensitizers can include selenium, fish oil, and a combination of selenium and fish oil to a cancer cell. The method contemplates that the selenium and fish oil are administered in an amount effective to respectively increase the sensitivity of the cancer cells, and the administration of the combination of selenium and fish oil are administered in an amount effective to synergistically increase the sensitivity of the cancer cells more than the selenium or the fish oil alone. The method additionally exposes cancer cells to temperatures in excess of 37° C.

IPC Classes  ?

• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61P 35/00 - Antineoplastic agents

Abstract

A nutritional supplement is described that enhances and provides synergistic effects when used in combination with radiotherapy to treat tumors, both reducing tumor size and preventing metastasis. The nutritional supplement has been also found to be effective in reducing negative side effects of concurrent radiotherapy, including inflammation, weight loss, muscle wasting, neutropenia, and loss of cells from the lining of the gut. Date Recue/Date Received 2024-02-02

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A23L 33/115 - Fatty acids or derivatives thereofFats or oils
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A23L 33/17 - Amino acids, peptides or proteins
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 35/00 - Antineoplastic agents

Abstract

A nutritional supplement is described that enhances and provides synergistic effects when used in combination with radiotherapy to treat tumors, both reducing tumor size and preventing metastasis. The nutritional supplement has been also found to be effective in reducing negative side effects of concurrent radiotherapy, including inflammation, weight loss, muscle wasting, neutropenia, and loss of cells from the lining of the gut.

IPC Classes  ?

• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A23L 27/00 - SpicesFlavouring agents or condimentsArtificial sweetening agentsTable saltsDietetic salt substitutesPreparation or treatment thereof
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/115 - Fatty acids or derivatives thereofFats or oils
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A23L 33/17 - Amino acids, peptides or proteins
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy