Abstract

There is provided an intraoral formulation comprising a solid, porous chemically bonded ceramic system, nicotine or a salt thereof, and a pH regulating agent, wherein the chemically bonded ceramic system is formed in the absence of said pH regulating agent. The formulations comprise nicotine and have particular utility in aiding smoking cessation, treating nicotine dependence, alleviating the symptoms of nicotine dependence and other medical uses for which nicotine is known.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/465 - NicotineDerivatives thereof
• A61K 47/02 - Inorganic compounds
• A61P 25/34 - Tobacco-abuse

Abstract

There is provided a powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system. An intraoral formulation containing the powder may be held in the mouth where it releases the nicotine and contributes to providing an environment that facilitates nicotine uptake into the blood stream.

IPC Classes  ?

• A24B 15/42 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic and inorganic substances
• A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
• A24B 15/28 - Treatment of tobacco products or tobacco substitutes by chemical substances
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/465 - NicotineDerivatives thereof

Abstract

There is provided an intraoral formulation comprising a solid, porous chemically bonded ceramic system, nicotine or a salt thereof, and a pH regulating agent, wherein the chemically bonded ceramic system is formed in the absence of said pH regulating agent. The formulations comprise nicotine and have particular utility in aiding smoking cessation, treating nicotine dependence, alleviating the symptoms of nicotine dependence and other medical uses for which nicotine is known.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/465 - NicotineDerivatives thereof
• A61K 47/02 - Inorganic compounds
• A61P 25/34 - Tobacco-abuse

Abstract

There is provided an intraoral composition comprising an alkaline active pharmaceutical agent, or a salt thereof, and a chemically bonded ceramic system formed from a substance selected from the group consisting of calcium aluminates, calcium silicates, calcium phosphates and mixtures thereof. The intraoral composition may be held in the mouth where it releases the alkaline active pharmaceutical agent and contributes to providing an environment that facilitates uptake into the blood stream. Active pharmaceutical agents of particular interest include nicotine and opioid analgesics.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61K 31/465 - NicotineDerivatives thereof
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61K 47/02 - Inorganic compounds

Abstract

There is provided an intraoral composition comprising an alkaline active pharmaceutical agent, or a salt thereof, and a chemically bonded ceramic system formed from a substance selected from the group consisting of calcium aluminates, calcium silicates, calcium phosphates and mixtures thereof. The intraoral composition may be held in the mouth where it releases the alkaline active pharmaceutical agent and contributes to providing an environment that facilitates uptake into the blood stream. Active pharmaceutical agents of particular interest include nicotine and opioid analgesics.

IPC Classes  ?

• A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
• A24F 23/02 - Tobacco pouches
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/465 - NicotineDerivatives thereof
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61K 47/02 - Inorganic compounds
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/34 - Tobacco-abuse

Abstract

There is provided an intraoral formulation comprising a solid, porous chemically bonded ceramic system, nicotine or a salt thereof, and a pH regulating agent, wherein the chemically bonded ceramic system is formed in the absence of said pH regulating agent. The formulations comprise nicotine and have particular utility in aiding smoking cessation, treating nicotine dependence, alleviating the symptoms of nicotine dependence and other medical uses for which nicotine is known.

IPC Classes  ?

• A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
• A24F 23/02 - Tobacco pouches
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/465 - NicotineDerivatives thereof
• A61K 47/02 - Inorganic compounds
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/34 - Tobacco-abuse

Abstract

There is provided a powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system. An intraoral formulation containing the powder may be held in the mouth where it releases the nicotine and contributes to providing an environment that facilitates nicotine uptake into the blood stream.

IPC Classes  ?

• A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
• A24F 23/02 - Tobacco pouches
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/465 - NicotineDerivatives thereof
• A61K 47/02 - Inorganic compounds
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/34 - Tobacco-abuse

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapour to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporise the deliverable agent. Deliverable agents that may be delivered to the user include active pharmaceutical ingredients. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A61M 15/00 - Inhalators
• A24F 40/42 - Cartridges or containers for inhalable precursors
• A61P 25/34 - Tobacco-abuse
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/465 - NicotineDerivatives thereof
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61M 16/10 - Preparation of respiratory gases or vapours

Abstract

A transdermal drug administration device comprising a drug delivery element (10) defining a contact surface (12) for location, in use, against a patient's skin. The drug delivery element (10) includes a sustained-release pharmaceutical composition. The composition comprises a network of a carrier material having a high mechanical strength and an active pharmaceutical ingredient. The active pharmaceutical ingredient is co-formedly interspersed within pores in the solid, continuous network of the carrier material.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 47/02 - Inorganic compounds
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapour to a user. The device comprises a solid, porous carrier material, and plant material (comprising the deliverable agent) located within voids in the carrier material. The device is operable to heat the carrier material and thereby heat the plant material, such as tobacco, to vaporise the deliverable agent. Deliverable agents that may be delivered to the user include nicotine. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A24D 1/14 - Tobacco cartridges for pipes
• A24F 47/00 - Smokers’ requisites not otherwise provided for

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapor to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporize the deliverable agent. Deliverable agents that may be delivered to the user include nicotine. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A61M 15/00 - Inhalators
• A24F 40/42 - Cartridges or containers for inhalable precursors
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/465 - NicotineDerivatives thereof
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61M 11/04 - Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61P 25/34 - Tobacco-abuse
• G05D 23/24 - Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature the sensing element having a resistance varying with temperature, e.g. thermistor
• A24F 40/465 - Shape or structure of electric heating means specially adapted for induction heating

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapour to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporise the deliverable agent. Deliverable agents that may be delivered to the user include active pharmaceutical ingredients. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A61M 15/00 - Inhalators
• A24F 40/42 - Cartridges or containers for inhalable precursors
• A61P 25/34 - Tobacco-abuse
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61K 31/465 - NicotineDerivatives thereof
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61M 11/04 - Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
• A24F 40/465 - Shape or structure of electric heating means specially adapted for induction heating
• G05D 23/24 - Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature the sensing element having a resistance varying with temperature, e.g. thermistor

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapour to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporise the deliverable agent. Deliverable agents that may be delivered to the user include active pharmaceutical ingredients. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A61M 15/00 - Inhalators
• A24F 47/00 - Smokers’ requisites not otherwise provided for

Abstract

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapour to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporise the deliverable agent. Deliverable agents that may be delivered to the user include nicotine. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials.

IPC Classes  ?

• A61M 15/00 - Inhalators
• A24F 47/00 - Smokers’ requisites not otherwise provided for

Abstract

There is provided a sustained-release pharmaceutical composition comprising a solid, continuous network comprising an excipient with a high mechanical strength, which network also comprises pores, within which pores is interspersed a mixture of an active ingredient and a film-forming agent, characterised in that said pores are formed during the production of the composition. Compositions of the invention find particularly utility as abuse-resistant formulations comprising opioid analgesics that may be employed in the treatment of chronic pain.

IPC Classes  ?

• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

A transdermal drug administration device comprising a drug delivery element attached to a solvent-swellable and/or solvent-soluble substrate, wherein the drug delivery element defines a contact surface for location, in use, against a patient's skin. The drug delivery element comprises an active pharmaceutical ingredient and a porous solid material.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/4168 - 1,3-Diazoles having a nitrogen atom attached in position 2, e.g. clonidine
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Abstract

A transdermal drug administration device comprising a drug delivery element (10) defining a contact surface (12) for location, in use, against a patient's skin. The drug delivery element (10) includes a sustained-release pharmaceutical composition. The composition comprises a network of a carrier material having a high mechanical strength and an active pharmaceutical ingredient. The active pharmaceutical ingredient is co-formedly interspersed within pores in the solid, continuous network of the carrier material.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 47/02 - Inorganic compounds
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present invention relates to a sustained release medical composition comprising an active pharmaceutical ingredient and a geopolymeric binder. Preferably the active pharmaceutical ingredient is combined with the geopolymeric binder during the formation of that binder.

IPC Classes  ?

• A61K 47/02 - Inorganic compounds
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl

Abstract

There is provided a sustained-release pharmaceutical composition comprising a solid, continuous network comprising an excipient with a high mechanical strength, which network also comprises pores, within which pores is interspersed a mixture of an active ingredient and a film-forming agent, characterized in that said pores are formed during the production of the composition. Compositions of the invention find particularly utility as abuse-resistant formulations comprising opioid analgesics that may be employed in the treatment of chronic pain.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets