A brucine gel formulation, a preparation method therefor and use thereof. Said gel formulation comprises 0.5%-1% of brucine, 0.5%-3% of a gel matrix and 10%-30% of a co-solvent. Said brucine hydrogel does not contain a transdermal enhancer, but has an excellent transdermal effect, is easy to coat, has good biosolubility, good skin absorption and good drug film adhesion, and is non-irritating to the skin and mucosa.
A brucine gel plaster and a preparation method therefor. The brucine gel plaster comprises, calculated by weight percentage, 0.3%-2% of brucine, 3%-10% of a framework material, 20%-50% of a humectant and a co-solvent, 0.1%-2% of a crosslinking agent and a crosslinking regulator, and the balance of water, a backing layer and an anti-sticking layer. The brucine gel plaster uses simple medicinal excipients, does not use a transdermal enhancer, has good skin compatibility, is moisturizing and breathable, is non-irritating to the skin and mucous membranes, has a large drug load, and can be applied repeatedly. The paste is used for treating or ameliorating related diseases requiring anti-inflammation and analgesia such as osteoarthritis, rheumatoid arthritis and rheumatoid arthritis.
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A brucine gel formulation, a preparation method therefor and use thereof. Said gel formulation comprises 0.5% - 1% of brucine, 0.5% - 3% of a gel matrix and 10% - 30% of a co-solvent. Said brucine hydrogel does not contain a transdermal enhancer, but has an excellent transdermal effect, is easy to coat, has good biosolubility, good skin absorption and good drug film adhesion, and is non-irritating to the skin and mucosa.
The present invention belongs to the field of medicine and relates to a method for preparing an extract of Strychnos nux-vomica, the method comprising: (1) soaking Strychnos nux-vomica with a first alkaline solution, followed by performing solid-liquid separation to obtain a solid matter; (2) extracting the solid matter obtained in step (1) with ethyl acetate, followed by performing solid-liquid separation to obtain an extraction solution (3) subjecting the extraction solution obtained in step (2) to silica gel column chromatography to obtain an eluate, the eluent being an absolute ethanol or an ethanol solution added with at least one of an ammonia solution, a potassium carbonate solution, a sodium carbonate solution, a sodium bicarbonate solution and potassium bicarbonate solution; (4) drying the eluate to obtain a dried matter; (5) dissolving the dried matter in an acid solution, followed by performing solid-liquid separation to obtain a liquid matter; (6) adjusting the pH value of the liquid matter obtained in step (5) to 8-13, followed by performing solid-liquid separation to obtain a solid matter; and (7) subjecting the solid matter obtained in step (6) to recrystallization. The present invention relates to the extract of Strychnos nux-vomica and a medical use thereof. The extract of Strychnos nux-vomica of the present invention has a high content of brucine and a low content of strychnine, and is safe and effective for use.
C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medicines for human purposes; pharmaceutical preparations;
chemico-pharmaceutical preparations; dietetic substances
adapted for medical use; tonics [medicines]. Technological research; conducting technical project
studies; scientific research; research and development of
new products for others; clinical trials; chemical research;
cosmetic research; biological research; chemistry services;
scientific laboratory services.
6.
SPRAY-DRYING METHOD FOR POGOSTEMON CABLIN GRANULAR FORMULATION
A spray-drying method for Pogostemon cablin granular formulation, comprising the following steps: taking a concentrated Pogostemon cablin extractum, adding 2% to 5% of beta-cyclodextrin, mixing uniformly, performing filtration, performing spray drying under conditions of an inlet air temperature of 175 °C to 180 °C and an outlet air temperature of 90 °C to 95 °C and collecting dry powders. The concentrated extractum has a relative density of 1.02 to 1.10 at 60 °C.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medicines for human purposes; capsules for medicines;
pharmaceutical preparations; chemico-pharmaceutical
preparations; suppositories. Technical research; conducting technical project studies;
research and development of new products for others;
scientific research; quality control; chemical analysis;
chemistry services; chemical research; clinical trials.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medicines for human purposes; pharmaceutical preparations. Clinical trials; chemical research; technical research;
scientific research; research and development of new
products for others; chemistry services; cosmetic research;
scientific laboratory services; conducting technical project
studies; biological research.
