Medical devices, namely, stent grafts, snares, delivery catheters and guidewires for treating vascular disease; Stent grafts for improving blood flow in patients with peripheral artery disease
Medical devices for treating vascular disease in the nature of artificial stent grafts and delivery catheters; Synthetic stent grafts for improving blood flow in patients with peripheral artery disease
A stent includes a first wire and a second wire. The first wire is helically wound along an axis of a main body portion of the stent and along an axis of a first branch portion of the stent. The second wire is helically wound along the axis of the main body portion of the stent and along an axis of a second branch portion of the stent. The first wire and the second wire are encapsulated in a graft member. A method for making a stent includes winding a first wire helically along a main body portion of a bifurcated mandrel and a first leg portion of the bifurcated mandrel. The method further includes winding a second wire helically along the main body portion of the bifurcated mandrel and a second leg portion of the bifurcated mandrel. The first and second wires can be laminated within a graft material.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
5.
STENT GRAFT SYSTEMS AND METHODS WITH CUFF AND LIMB
A stent graft system includes a first graft, a second graft, and a third graft. Each of the first graft, the second graft, and the third graft forms a single lumen. When deployed, the first graft, the second graft, and the third graft are coupled together within an aorta.
A61F 2/852 - Two or more distinct overlapping stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/94 - Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
6.
STENT GRAFT SYSTEMS AND METHODS WITH INFLATABLE FILL STRUCTURE AND TILLABLE CUFF
A stent graft system includes a stent graft, an inflatable fill structure, and a cuff. The inflatable fill structure at least partially surrounds the stent graft. In various arrangements, the inflatable fill structure has a cavity that is bifurcated. A portion of the cavity is configured to receive a branch stent graft for connection to the stent graft. The cuff is fillable and is located outside of the inflatable fill structure, and allows for providing a seal with a wall of a blood vessel. The cuff and the inflatable fill structure are separately fillable from each other to different pressures with fill medium. In various arrangements, the cuff has a tapered shape such that it is wider at one end than at an opposite end when filled with a fill medium. A method includes filling the cuff to a higher pressure than a pressure of the inflatable fill structure.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A61F 2/852 - Two or more distinct overlapping stents
A61F 2/856 - Single tubular stent with side portal passage
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
7.
STENT GRAFT SYSTEMS WITH RESTRAINTS IN CHANNELS AND METHODS THEREOF
A stent graft system includes a first layer of graft material, a second layer of graft material, one or more stent members, one or more reducing belts, and a release wire. The one or more stent members are located between the first layer of graft material and the second layer of graft material. The second layer of graft material is formed to have a corresponding channel over each of the one or more stent members. The one or more reducing belts each include a loop at both ends and each is located in a corresponding channel around a corresponding one of the stent members. The release wire passes through both loops of each of the one or more reducing bel ts when the one or more stent members are in a compressed state. Pulling the release wire allows for the stent graft system to radially expand.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
8.
SYSTEMS AND METHODS WITH ANCHOR DEVICE FOR FIXATION OF FILLING STRUCTURES IN BLOOD VESSELS
A system, for deployment in a blood vessel includes an anchor device having a stent and a suture loop that joins distal end portions of the stent. A first filling structure and a second filling structure are at least partially insertable through the suture loop to an area within the stent when the stent is in an expanded state. The anchor device has a size such that at least a portion of the first filling structure and at least a portion of the second filling structure protrude through openings in the anchor device to form a seal against a wall of the blood vessel when the first filling structure and the second filling structure have been at least partially inserted through the suture loop and have been filled. A method allows for repairing one or more blood vessels using the system.
A method of treating an aortic aneurysm of a patient with an endovascular graft system and mitigating post implant syndrome associated therewith comprises placing at least one prosthesis across an aneurysmal space. The prosthesis comprises a double-walled filling structure and a stent-graft. The stent graft is radially expanded at a first pressure and the filing structure is filled with a first filing agent to contact a thrombus in the aortic aneurysmal space. After the first filling agent is removed, the filling structure is filled with a second filling agent to contact the thrombus. Next the stent-graft is expanded at a second pressure causing the filing structure to place an effective amount of pressure on the thrombus and substantially mitigating the effects of post implant syndrome associated with the prosthesis.
Various embodiments relate to compositions for use in endoluminal devices and to methods of using compositions in endoluminal devices. The compositions include two parts, a first part including a first solution and a second part including a second solution, wherein the first solution comprises one or more pre-polymers, a non-aqueous solvent, a polymerization co-initiator or initiator and optionally one or more chain extenders and additives, and the second solution comprises a polymerization initiator or co-initiator, a non-aqueous solvent and optionally one or more chain extenders and additives.
C08L 33/00 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereofCompositions of derivatives of such polymers
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
11.
STENT GRAFTS AND METHODS OF ENHANCING FLEXIBILITY OF STENT GRAFTS BY THERMAL PLEATING
A method for forming pleats in a stent graft, includes forming pleats in a graft material of the stent graft by compressing the stent graft, applying heat to the stent graft to thermally set the pleats in the graft material, and extending the stent graft to uncompress the stent graft after the pleats are thermally set.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/01 - Filters implantable into blood vessels
Endovascular systems for deployment at branched arteries include a main tubular graft body deployable within a main artery including a proximal end and an opposed distal end. The proximal and distal ends have a tubular graft wall therein between. A plurality of inflatable channels are disposed along the main tubular graft body, and at least one stent segment is disposed along the tubular graft wall of the main tubular graft body. The plurality of inflatable channels are configured to be inflatable with an inflation medium. The at least one stent segment is disposed between two or more adjacent inflatable channels of the plurality of inflatable channels.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
13.
ENDOVASCULAR SYSTEMS, DEVICES, AND METHODS ALLOWING FOR BRANCH DEVICE PLACEMENT IN CHANNEL OF MAIN GRAFT
Endovascular stent grafts in accordance with various embodiments include one or more channels on a main body graft, the one or more channels defining a passageway for receiving one or more branch portions for treating branch vessels. In various embodiments, the one or more channels on the main body graft may be abluminal, adluminal, or weaved, with respect to a stent structure of the main body graft.
A stent graft system includes a stent graft, a radially expandable scaffold, and an inflatable fill structure. The stent graft includes a body portion with a plurality of pleated sections that are configured to be extended from a telescopically compressed state to a longitudinally extended state. The radially expandable scaffold is attached to a top of the body portion, and has one or more fixation elements for penetrating into an aortic wall. The inflatable fill structure is attached at a top of the body portion and is configured to expand in a longitudinal direction as the body portion is extended in the longitudinal direction. The inflatable fill structure is also configured to expand in a radial direction to contact an inner surface of a blood vessel.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/844 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A61F 2/852 - Two or more distinct overlapping stents
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/945 - Stents retaining their form, i.e. not being deformable, after placement in the predetermined place hardenable, e.g. stents formed in situ
A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
15.
SYSTEMS AND METHODS WITH STENT AND FILLING STRUCTURE
A system includes a filling structure deployable at least partially in a common iliac artery and an external iliac artery, and a scaffold positioned within a first lumen of the filling structure. The scaffold has a fenestration in a side of the scaffold that is positionable toward an internal iliac artery. The filling structure has a second lumen extending from the first lumen and positionable toward the internal iliac artery. A method includes deploying a filling structure at least partially in a common iliac artery and an external iliac artery and positioning a scaffold within a lumen of the filling structure such that a fenestration in a side of the scaffold is positioned toward an internal iliac artery.
A system for placement in at least one blood vessel includes a main graft body, one or more inflatable channels, and a filling structure. The one or more inflatable channels are attached to the main graft body. The filling structure is inflatable around at least a portion of the main graft body and at least a portion of at least one of the one or more inflatable channels. Various systems further include a graft extension that is insertable into a lumen formed by the main graft body, where the filling structure is inflatable around at least a portion of the graft extension. A method includes inserting a main graft body into a blood vessel, filling an inflatable channel attached to the main graft body, and filling a filling structure to inflate around at least a portion of the main graft body and at least a portion of the inflatable channel.
A system includes a graft body and a filling structure. The graft body has a fenestration in a side surface through which a support structure is insertable. The filling structure has an internal volume that is fillable with a filling medium and is configured to have a conduit through the internal volume through which the support structure is insertable. The conduit in the filling structure is alignable with the fenestration in the graft body such that the support structure is insertable through both the conduit in the filling structure and the fenestration in the graft body.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software for collecting, storing and managing data
and images for use by physicians and health care
professionals to create medical treatment plans and medical
devices and apparatus for patients. Medical apparatus and instruments for treating
cardiovascular disease or cardiovascular disorders; medical
devices, namely, endovascular balloon catheters, devices for
the treatment of aneurysms, AAA stent grafts and stent
grafts for treating aneurysms and vascular disease or
cardiovascular disorders, renal stent grafts for the
treatment of aneurysms; fitted stent covers and sleeves made
from textiles and/or woven fabric; polymer closure devices,
namely, abdominal aortic aneurysm (AAA) stent grafts and
stent grafts used in the treatment of vascular and
cardiovascular disease or cardiovascular disorders; medical
polymers for use as a closure device, namely, abdominal
aortic aneurysm (AAA) stent grafts and stent grafts; medical
polymers in the nature of closure devices for treating
vascular aneurysms, namely, abdominal aortic aneurysm (AAA)
stent grafts and stent grafts; medical devices for treating
vascular aneurysms; medical apparatus and instruments for
treating vascular and cardiovascular disease; stent delivery
systems; stents; synthetic stent grafts; artificial vascular
grafts; catheters and parts and fittings therefor; medical
devices, namely, minimally invasive devices for aortic
disease repair; medical introducers; medical devices for use
in vascular and cardiovascular procedures, namely,
catheters, wires, syringes, injection devices; endovascular
stent-grafts, endovascular stents, endovascular grafts and
catheter delivery systems, consisting primarily of one or
more long tubes, intended for use in the treatment of
abdominal and thoracic aortic aneurysms; medical devices,
all for the treatment of vascular disease, namely, stents,
synthetic endovascular grafts, vascular prostheses,
synthetic thoracic stent grafts, synthetic abdominal stent
grafts, vascular implants comprising artificial material;
vascular implant delivery systems comprised of catheters,
valves, sheaths, handles and chassis; and accessories for
the aforesaid goods, namely, introducer sheaths, curable
polymeric implant fill material, implant fill material
mixing devices, implant fill material injectors and implant
fill material syringes; vascular implant delivery systems
comprised of catheters, valves, sheaths, handles and
chassis; and accessories for the aforesaid goods, namely,
introducer sheaths, curable polymeric implant fill material,
implant fill material mixing devices, implant fill material
injectors and implant fill material syringes; medical
devices, namely, endovascular balloons. Scientific research for medical purposes in the field of
cardiovascular disease or cardiovascular disorders;
providing information in the field of clinical evidence in
the nature of clinical research information, and medical and
scientific research information regarding medical
procedures; providing online, non-downloadable software
enabling physicians and health care professionals to
collaborate in connection with medical records, images and
information to treat patients; providing temporary use of
on-line non-downloadable software for collecting, storing
and managing data and images for use by physicians and
health care professionals to create medical treatment plans
and select medical devices and apparatus for patients;
providing online, non-downloadable software for collecting,
storing and managing data and images for use by physicians
and health care professionals to create medical treatment
plans and select medical devices and apparatus for patients. Providing medical information on medical treatments, medical
procedures and medical devices and apparatuses for
physicians and health care professionals; providing medical
information to educate physicians, health care professionals
and patients on medical treatments, devices and apparatus.
19.
LOCKING ASSEMBLY FOR COUPLING GUIDEWIRE TO DELIVERY SYSTEM
A locking assembly for releasably coupling a first elongate member to a second elongate member is provided. The locking assembly can include a first lumen for anchoring the locking assembly to a catheter and a second lumen for releasably retaining a guidewire to the locking assembly. A release member can interface with the locking assembly and apply a force that decouples the guidewire from the locking assembly.
A stent includes a main body having a plurality of rings that form a helix. Each of the plurality of rings includes a plurality of skewed v-shaped elements that each have a first leg and a second leg that is longer than the first leg. The stent further includes a first end ring and a second end ring positioned to an opposite side of the main body from the first end ring. Each of the plurality of rings of the main body is angled with respect to the first end ring and the second end ring. The stent further includes a first transitional region for connecting the first end ring to the main body, and a second transitional region for connecting the second end ring to the main body.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A system includes an inner filling structure around a stent-structure and an outer filling structure around the inner filling structure. The inner filling structure can be configured to produce a proximal seal with a first portion of an artery at a proximal end and a distal seal with a second portion of an artery at a distal end when the inner filling structure is in an inflacted state. The outer filling structure can have an inner surface surrounding at least a portion of the inner filling strucutre. The outer filling structure can be configured to be inflatable to occupy a space within an aneurysm at a lower pressure than a pressure in the inner filling structure.
An apparatus includes a first stent graft that is at least partially insertable into a first blood vessel. The first stent graft has a first end, a second end, an inside surface, and an outside surface. The apparatus also includes an inflatable fill structure fixed to a portion of the outside surface of the first stent graft. The inflatable fill structure includes an outer membrane that is configured to extend beyond the first end of the first stent graft when the inflatable fill structure is in a filled state.
The present invention provides a dry powder that is suitable for use in forming a hydrogel and characterized by a stable composition at ambient conditions. The dry powder includes a prepolymer including a straight chain polyethylene glycol, and a thermally activated free radical initiator selected from the group consisting of sodium persulfate, potassium persulfate, and ammonium persulfate. The present invention also provides a method of forming the dry powder, and a method of preparing a hydrogel where a reaction mixture is formed including the dry powder and a buffered aqueous solution.
Fitted stent covers and sleeves made from textiles and/or
woven fabric; polymer closure devices, namely, abdominal
aortic aneurysm (AAA) stent grafts and stent grafts used in
the treatment of vascular and cardiovascular disease;
medical polymers for use as a closure device, namely,
abdominal aortic aneurysm (AAA) stent grafts and stent
grafts; medical polymers in the nature of closure devices
for treating vascular aneurysms, namely, abdominal aortic
aneurysm (AAA) stent grafts and stent grafts.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software for collecting, storing and managing data
and images for use by physicians and health care
professionals to create medical treatment plans and select
medical devices and apparatus for patients. Providing online, non-downloadable software enabling
physicians and health care professionals to collaborate in
connection with medical records, images and information to
treat patients; providing temporary use of on-line
non-downloadable software for collecting, storing and
managing data and images for use by physicians and health
care professionals to create medical treatment plans and
select medical devices and apparatus for patients; providing
online, non-downloadable software for collecting, storing
and managing data and images for use by physicians and
health care professionals to create medical treatment plans
and select medical devices and apparatus for patients. Providing medical information on medical treatments, medical
procedures and medical devices and apparatuses for
physicians and health care professionals; providing medical
information to educate physicians, health care professionals
and patients on medical treatments, devices and apparatus.
(1) Fitted stent covers and sleeves made from textiles and/or woven fabric; polymer closure devices, namely, abdominal aortic aneurysm (AAA) stent grafts and stent grafts used in the treatment of vascular and cardiovascular disease; medical polymers for use as a closure device, namely, abdominal aortic aneurysm (AAA) stent grafts and stent grafts; medical polymers in the nature of closure devices for treating vascular aneurysms, namely, abdominal aortic aneurysm (AAA) stent grafts and stent grafts
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients. (1) Providing information on medical treatments, medical procedures and medical devices and apparatuses for physicians and health care professionals; providing software enabling physicians and health care professionals to collaborate in connection with medical records, images and information to treat patients; providing temporary use of on-line non-downloadable software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients; providing software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients; providing information to educate physicians, health care professionals and patients on medical treatments, devices and apparatus.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients. Providing information on medical treatments, medical procedures and medical devices and apparatuses for physicians and health care professionals; providing software enabling physicians and health care professionals to collaborate in connection with medical records, images and information to treat patients; providing temporary use of on-line non-downloadable software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients; providing software for collecting, storing and managing data and images for use by physicians and health care professionals to create medical treatment plans and select medical devices and apparatus for patients; providing information to educate physicians, health care professionals and patients on medical treatments, devices and apparatus.
29.
METHOD FOR FORMING MATERIALS IN SITU WITHIN A MEDICAL DEVICE
A method for forming a material in an in situ medical device by initiating polymerization of water soluble polymer precursors in an aqueous solution during or after transport of the polymerizable solution from its storage container to a space inside the in situ medical device is described. The stored aqueous solution with water soluble precursors lacks a free radical initiator which, in a powder form, is introduced into the aqueous solution during or after its transport into the space inside the in situ medical device. This storage and delivery system provides greater stability to the stored aqueous solution, allowing it to be stored at ambient temperature and providing extended shelf life over the solutions used in existing in situ polymerization systems. The flexibility to store and deliver/transport only one aqueous solution, instead of requiring the use of two different solutions, is also a benefit.
(1) Medical devices, namely, endovascular stent grafts for the treatment of aneurysms, excluding devices for use in cosmetic or aesthetic practice or procedures
31.
METHOD AND SYSTEM FOR ENDOVASCULAR ANEURYSM TREATMENT
Methods for treatment of aneurysms using a sequential manifold console to deploy multiple filling structures are provided herein. In one aspect, aneurysms are treated by simultaneously filling two double-walled filling structure using a sequential manifold console to guide a user in the steps to be followed in the procedure and to reliably achieve a consistent and durable aneurysmal treatment using a curable medium. The structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Pairs of filling structures delivered to the aneurysm from different access openings of a patient can be simultaneously prepared and pressurized from a single treatment console when treating abdominal aortic aneurysms using the described systems and methods.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A modular catheter system including a sheath (127) projecting distally from a delivery catheter having a main body module (121) An inner core module (115) carrying a stent thereon, the inner core being axially movable through the main body of the delivery catheter and the delivery catheter sheath, a handle member (138) supported by the main body of the delivery catheter, the handle member being selectively axially engageable with the inner core such that the handle member and the inner core move together in an axial direction when the handle member is engaged with the inner core; and an adjustment member (130) supported by the main body, the adjustment member being configured such that rotation of the adjustment member causes the adjustment member to move axially along the main body by either axially sliding the handle member relative to the main body or by rotating the adjustment member.
A system for treating an aneurysm comprises an elongate flexible shaft and a nosecone. An expandable member may be used to expand an expandable endoframe within a double-walled filling structure. The filling structure is adapted to be filled with a hardenable fluid filing medium so that an outer wall conforms to an inside surface of the aneurysm and an inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the endoframe engages the inner wall of the filling structure. One or more tethers releasably couple the filling structure and/or endoframe with the shaft thereby constraining axial movement of the structures relative to each other. The nosecone is constructed to have a series of side ports and a through lumen such that the nosecone can be positioned with a guidewire and simultaneously receive a contrast media for performing angiography through the lumen.
A device system and method for the treatment of aortic dissections comprising placing a stent in the true lumen and displacing the blood in the false lumen with an inflatable bag. An exemplary method of treating an aortic dissection having a true lumen and a false lumen, comprises: deploying a support structure in the true lumen of a blood vessel adjacent to or overlapping a portion of the dissection to maintain the true lumen in an open state; advancing an inflatable structure in a collapsed state into the false lumen; and inflating the inflatable structure to displace the blood in the false lumen.
A fenestrated graft deployment system, with a delivery catheter having a catheter body, An endoluminal prosthesis having a main graft body, the main graft body having a lumen therethrough and a first opening laterally through a wall of the main graft body. A first guidewire prepositioned within the delivery catheter extending through at least a portion of the catheter body into a main lumen of the endoluminal prosthesis and through the first opening in the wall of the prosthesis when the delivery catheter is in a predeployed configuration. A first fenestration alignment device (20, 26) is configured to extend through at least a portion of the delivery catheter and is configured to be axially moveable relative to the first guidewire. The first fenestration alignment device has an end portion having an outside perimeter configured such that when an end portion of the fenestration alignment device moves toward the first opening of said main graft body the outside perimeter of the first opening is smaller than the outside perimeter of the first fenestration alignment device and prevents it from passing through the first opening and causes the main graft body adjacent to the first opening to move with the end of the first fenestration alignment device to act as alignment tool to allow an operator to align the first opening in the side of the endoluminal prosthesis with an ostium of a target branch vessel into which said first opening is to extend and act as a guide and seal for a subsequently delivered branch graft endoluminal prosthesis.
A system for treating an aneurysm includes a first double-walled filling structure having an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a generally tubular lumen to permit blood flow therethrough. The inner wall comprises a blood contacting layer and a reinforcing layer. The reinforcing layer prevents circumferential creep or elastic expansion of the lumen.
Some embodiments are directed to a stent graft comprising a first stent graft having a first stent, a first inner graft supported by the first stent, a second inner graft supported by the first stent, and an outer graft. The second inner graft can be spaced apart from the first inner graft along the length of the first stent so that a portion of the first stent is not covered by either the first inner graft or the second inner graft. A first portion and a second portion of the outer graft can be attached to the first stent, the outer graft being unsupported by the stent between the first and second portions so as to form a fillable space between the outer graft, the first inner graft, and the second inner graft. Some embodiments further comprise a second stent graft deployable within the inside of the first stent graft to sealingly cover the uncovered portion of the first stent.
Some embodiments are directed to a deployment system for deploying a stent graft within a passageway, comprising a delivery catheter having an outer sheath, a proximal end, and a distal end, a stent having a first end and a second end, a graft having a first end and a second end, and at least one connecting element extending from the second end of the stent to the first end of the graft so as to connect the stent to the graft. In some embodiments, the stent can be supported within the outer sheath at a first axial position in a collapsed state, and the graft can be supported within the outer sheath at a second axial position different than the first axial position in a collapsed state, such that the stent does not overlap or substantially overlap the graft in the collapsed state within the deployment system.
Some embodiments relate to endoluminal prostheses having a first stent portion and a second stent portion, a main graft body comprising first, second, and third portions, the second portion having a cross-sectional size that is significantly larger than a cross-sectional size of the first or third portions, and also significantly larger than a cross-sectional size of the target vessel. In some embodiments, the first portion of the main graft body can be attached to the first stent portion and the third portion of the main graft body can be attached to the second stent portion. The prostheses can be configured such that the second portion of the main graft body is not directly attached to the first stent portion, the second stent portion, or any other internal support structure. In some embodiments, one or more openings can be formed in the second portion of the main graft body.
Some embodiments of the present disclosure are directed to methods and systems for percutaneously treating dissections in a patient's vasculature, such as, without limitation, the aorta. The method can include deploying a catheter containing a collapsed anchoring element, frame, and cover through a first vessel to an entry point of the dissection. In some embodiments, the anchoring element can be secured to the second branch vessel. The frame can be expanded in the first branch vessel. The cover can be unfolded over at least a portion of the entry point. The cover then reduces blood flow into the entry point.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
Embodiments are directed to a catheter system (100) comprising an introducer (102) having a main body (106), an introducer sheath (110) projecting from the main body, and a first seal supported within the introducer and a catheter (104) having a main body (140), an outer sheath (122) projecting from the main body, a second seal supported within the catheter, and an inner core (154) configured to be advanced axially through the main body, the second seal, and the outer sheath. The introducer can be configured to be selectively engageable with the catheter so that the catheter can be selectively and removably linked with the introducer in the axial direction. The catheter system can also be configured such that, when the introducer and the catheter are linked, the catheter can be rotatable relative to the introducer. The introducer can be configured to radially restrain an endoluminal prosthesis.
A system for treating an aneurysm in a blood vessel comprises a docking scaffold having with upstream and downstream ends, and a central passageway therebetween. The upstream end engages the blood vessel upstream of the aneurysm. A portion of a first and second scaffolds are slidably received in the central passageway such that an outside surface of the first and second scaffolds engage an inside surface of the docking scaffold. A double-walled filling structure has outer and inner walls and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow therethrough. The double-walled filling structure is coupled with at least one of the first and second leg scaffolds in expanded configuration.
A system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The first filling structure comprises a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal.
A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.
A deployment catheter for deploying an endoluminal vascular prosthesis that can have at least a main graft portion and a first branch graft portion. The deployment catheter can comprise an elongate, flexible catheter body having a proximal end and a distal end, and an outer sheath and an inner core that is axially moveable with respect to the outer sheath. The catheter can comprise a main graft restraint that has a main graft release mechanism comprising a main graft sheath and a suture or release wire threaded through a plurality of the openings in the main graft sheath. The catheter can further comprise at least one branch graft restraint comprising at least one branch graft release mechanism.
An endoluminal prosthesis system deployable in a region of a patient's vasculature having one or more branch vessels, having a first main graft body having at least a first and second opening therein and a second main graft body having at least a first and a second opening therein. The first openings can be smaller than the second openings. The second main graft body can be expandable substantially within the first main graft body such that the second openings of each graft body do not substantially cover the first openings of the other graft body. The resulting graft system can have two openings therein, each being defined by the first openings in each of the first and second main graft bodies. One or more branch grafts can be attached to cover the openings in the main graft bodies, and the main graft bodies can have one or more cutouts therein.
A prosthesis comprises a tubular body that is expandable from a contracted configuration to a radially expanded configuration. The tubular body has a total length and comprises a first section, a second section and a central section disposed therebetween. The total length of the tubular body in the expanded configuration is at least 95% of the total length of the tubular body in the contracted configuration. The three sections have a plurality of tubular rings, each with a plurality of struts having a length and coupled together to form a series of peaks and valleys. A connector couples adjacent tubular rings together. The length of the central section struts is different than the length of the other struts and the central section is coupled with both the first and second sections.
A method for stabilizing an extra cellular matrix layer in the vascular system of the body is disclosed herein. The method can comprise placing a vascular catheter adjacent to the extra cellular matrix layer, delivering a solution containing a bioflavonoid to the extra cellular matrix layer with the vascular catheter, and cross-linking protein in the extra cellular matrix layer. The bioflavonoid can be a catechin, particularly epigallocatechin gallate (EGCG).
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A tubular prosthesis can be formed by rolling a sheet of material about a longitudinal axis, thereby fo꧀ning a plurality of annular rings that can be arranged so as to be longitudinally adjacent one another, thus forming a tubular prosthesis. Each annular member can expand and contract independent of the other annular members. A graft material can extend between the plurality of annular members.
Medical devices, including, introducer sheaths, stent grafts, pusher rod assemblies, control cords, guidewires, retraction handles, hemostasis valves, stent graft covers, main body stent graft covers and limb stent graft covers.
A guidewire assembly (266) for use in deploying a bifurcated endoluminal vascular prosthesis (50) that has a main graft portion (52) and at least a first branch graft portion (54). The guidewire assembly include a hollow guidewire sheath (268) having a restraint mechanism (274), such as a tubular sheath, for constraining a branch graft portion of the vascular prosthesis and an inner core wire (270) that is slidably insertable into a central lumen of the hollow guidewire sheath. In use, the guidewire assembly may be used with a deployment catheter (120) to deploy the bifurcated vascular prosthesis (50) and leave the inner core wire (270) in position in the patient's aorta, extending through the main graft portion of the vascular prosthesis.
A deployment catheter (100) for deploying endoluminal vascular prosthesis that has at least a main graft portion and a first branch graft portion includes an elongate, flexible catheter body having a proximal end and a distal end and comprising an outer sheath (34) and an inner core (24) that is axially moveable with respect to the outer sheath. The catheter includes a main graft restraint (21) that has a main graft release mechanism (23) comprising a / plurality of axially spaced restraint members (22). The catheter further includes a branch graft restraint comprising a branch graft release mechanism.
The present invention provides multilayered materials, such as films usable in particular in medical devices in the form of vascular grafts, biocompatible coverings, and/or inflatable bladders, prosthesis for the endoluminal treatment of aneurysms, particularly aortic aneurysms including both abdominal aortic aneurysms (AAA's) and thoracic aortic aneurysms (TAA's).
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
B32B 27/06 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance
B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
B32B 3/10 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material
B32B 7/10 - Interconnection of layers at least one layer having inter-reactive properties
56.
METHODS AND SYSTEMS FOR ANEURYSM TREATMENT USING FILLING STRUCTURES
Aneurysms are treated by placing a scaffold across an aneurysmal sac to provide a blood flow lumen therethrough. An aneurysmal space surrounding the scaffold is filled with one or more expandable structures which are simultaneously or sequentially expanded to fill the aneurysmal space and reduce the risk of endoluminal leaks and scaffold migration. The expandable structures are typically inflatable and delivered by delivery catheter, optionally with an inflation tube or structure attached to the expandable structure.
Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.
Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.
