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Found results for
 patents
1.
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OXOPIPERAZINE DERIVATIVES
| Application Number |
18650360 |
| Status |
Pending |
| Filing Date |
2024-04-30 |
| First Publication Date |
2025-04-10 |
| Owner |
Inthera Bioscience AG (Switzerland)
|
| Inventor |
- Labelle, Marc
- Kessler, Ulrich
- Cattori, Valentino
- Cook, Cyril
- Vakiti, Ramkrishna Reddy
- Johnson, Kevin R. D.
- Kaur, Matinder
- Twibanire, Jean-D'Amour K.
- Ullah, Farman
|
Abstract
The present invention relates to novel compounds of formula (I) or formula (Ia)
The present invention relates to novel compounds of formula (I) or formula (Ia)
The present invention relates to novel compounds of formula (I) or formula (Ia)
pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
IPC Classes ?
- C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
- A61P 35/02 - Antineoplastic agents specific for leukemia
- C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C07D 471/04 - Ortho-condensed systems
- C07D 471/10 - Spiro-condensed systems
- C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- C07D 491/20 - Spiro-condensed systems
- C07D 495/04 - Ortho-condensed systems
- C07D 495/10 - Spiro-condensed systems
- C07D 497/10 - Spiro-condensed systems
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2.
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OXOPIPERAZINE DERIVATIVES FOR THE TREATMENT OF CANCER
| Document Number |
03292752 |
| Status |
Pending |
| Filing Date |
2024-05-24 |
| Open to Public Date |
2024-12-05 |
| Owner |
INTHERA BIOSCIENCE AG (Switzerland)
|
| Inventor |
- Vacher-Comet, Itys
- Cloos, Paul Andreas Compare
- Hentsch, Bernd
- Støier, Jonathan Fullerton
|
IPC Classes ?
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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3.
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OXOPIPERAZINE DERIVATIVES FOR THE TREATMENT OF CANCER
| Application Number |
EP2024064461 |
| Publication Number |
2024/245974 |
| Status |
In Force |
| Filing Date |
2024-05-24 |
| Publication Date |
2024-12-05 |
| Owner |
INTHERA BIOSCIENCE AG (Switzerland)
|
| Inventor |
- Vacher-Comet, Itys
- Cloos, Paul Andreas Compare
- Hentsch, Bernd
- Støier, Jonathan Fullerton
|
Abstract
The disclosure provides methods of treating a subject with a disease or disorder characterized by a modulated negative elongation factor complex (NELF) with a compound of Formula (Ia) or a pharmaceutically acceptable salt, hydrate, solvate, or stereoisomer thereof.
IPC Classes ?
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61P 35/00 - Antineoplastic agents
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4.
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Oxopiperazine derivatives for the treatment of cancer
| Application Number |
18002169 |
| Grant Number |
12611406 |
| Status |
In Force |
| Filing Date |
2021-12-18 |
| First Publication Date |
2023-07-20 |
| Grant Date |
2026-04-28 |
| Owner |
Inthera Bioscience AG (Switzerland)
|
| Inventor |
- Kessler, Ulrich
- Kessler, Beatrice Dolores Pilger
- Cattori, Valentino
|
Abstract
The present disclosure provides a method of treating a cancer comprising administering Compound 1:
or a pharmaceutically acceptable salt, hydrate, solvate, or stereoisomer thereof, to a subject in need thereof at a dosage disclosed herein.
IPC Classes ?
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61P 35/00 - Antineoplastic agents
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5.
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Oxopiperazine derivatives
| Application Number |
17570959 |
| Grant Number |
12012393 |
| Status |
In Force |
| Filing Date |
2022-01-07 |
| First Publication Date |
2022-07-07 |
| Grant Date |
2024-06-18 |
| Owner |
Inthera Bioscience AG (Switzerland)
|
| Inventor |
- Labelle, Marc
- Kessler, Ulrich
- Cattori, Valentino
- Cook, Cyril
- Vakiti, Ramkrishna Reddy
- Johnson, Kevin R. D.
- Kaur, Matinder
- Twibanire, Jean-D'Amour K.
- Ullah, Farman
|
Abstract
The present invention relates to novel compounds of formula (I) or formula (Ia)
pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
IPC Classes ?
- C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
- A61P 35/02 - Antineoplastic agents specific for leukemia
- C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C07D 471/04 - Ortho-condensed systems
- C07D 471/10 - Spiro-condensed systems
- C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- C07D 491/20 - Spiro-condensed systems
- C07D 495/04 - Ortho-condensed systems
- C07D 495/10 - Spiro-condensed systems
- C07D 497/10 - Spiro-condensed systems
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6.
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OXOPIPERAZINE DERIVATIVES FOR THE TREATMENT OF CANCER
| Application Number |
EP2021066611 |
| Publication Number |
2021/255239 |
| Status |
In Force |
| Filing Date |
2021-06-18 |
| Publication Date |
2021-12-23 |
| Owner |
INTHERA BIOSCIENCE AG (Switzerland)
|
| Inventor |
- Kessler, Ulrich
- Kessler, Beatrice Dolores Pilger
- Cattori, Valentino
|
Abstract
The present disclosure provides a method of treating a cancer comprising administering Compound 1: or a pharmaceutically acceptable salt, hydrate, solvate, or stereoisomer thereof, to a subject in need thereof at a dosage disclosed herein.
IPC Classes ?
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
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7.
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BIOMARKERS FOR DETERMINING SUSCEPTIBILITY TO OXOPIPERAZINE DERIVATIVES AND METHODS OF USING SAME
| Application Number |
EP2021050574 |
| Publication Number |
2021/144302 |
| Status |
In Force |
| Filing Date |
2021-01-13 |
| Publication Date |
2021-07-22 |
| Owner |
INTHERA BIOSCIENCE AG (Switzerland)
|
| Inventor |
- Cattori, Valentino
- Kessler, Ulrich
- Kessler, Beatrice Dolores Pilger
|
Abstract
The disclosure provides methods of treating a subject with cancer comprising determining the expression or activity of one or more genes in the p53 and/or Rb pathways, and administering a CBP/p300 modulating compound.
IPC Classes ?
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
|
8.
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Oxopiperazine derivatives
| Application Number |
16891417 |
| Grant Number |
11306068 |
| Status |
In Force |
| Filing Date |
2020-06-03 |
| First Publication Date |
2020-10-01 |
| Grant Date |
2022-04-19 |
| Owner |
Inthera Bioscience AG (Switzerland)
|
| Inventor |
- Labelle, Marc
- Kessler, Ulrich
- Cattori, Valentino
- Cook, Cyril
- Vakiti, Ramkrishna Reddy
- Johnson, Kevin R. D.
- Kaur, Matinder
- Twibanire, Jean-D'Amour K.
- Ullah, Farman
|
Abstract
The present invention relates to novel compounds of formula (I) or formula (Ia)
pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
IPC Classes ?
- C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C07D 497/10 - Spiro-condensed systems
- C07D 491/20 - Spiro-condensed systems
- C07D 471/10 - Spiro-condensed systems
- C07D 495/04 - Ortho-condensed systems
- C07D 495/10 - Spiro-condensed systems
- C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C07D 471/04 - Ortho-condensed systems
- C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
- A61P 35/02 - Antineoplastic agents specific for leukemia
|
9.
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Oxopiperazine derivatives
| Application Number |
16222479 |
| Grant Number |
10710975 |
| Status |
In Force |
| Filing Date |
2018-12-17 |
| First Publication Date |
2019-06-20 |
| Grant Date |
2020-07-14 |
| Owner |
Inthera Bioscience AG (Switzerland)
|
| Inventor |
- Labelle, Marc
- Kessler, Ulrich
- Cattori, Valentino
- Cook, Cyril
- Vakiti, Ramkrishna Reddy
- Johnson, Kevin R. D.
- Kaur, Matinder
- Twibanire, Jean-D'Amour K.
- Ullah, Farman
|
Abstract
The present invention relates to novel compounds of formula (I) or formula (Ia)
pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
IPC Classes ?
- C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C07D 497/10 - Spiro-condensed systems
- C07D 491/20 - Spiro-condensed systems
- C07D 471/10 - Spiro-condensed systems
- C07D 495/04 - Ortho-condensed systems
- C07D 495/10 - Spiro-condensed systems
- C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C07D 471/04 - Ortho-condensed systems
- C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00 - Antineoplastic agents
- A61P 35/02 - Antineoplastic agents specific for leukemia
|
10.
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1 -(PIPERIDINOCARBONYLMETHYL)-2-OXOPIPERAZINE DERIVATIVES FOR TREATING CANCER
| Application Number |
US2018066027 |
| Publication Number |
2019/118973 |
| Status |
In Force |
| Filing Date |
2018-12-17 |
| Publication Date |
2019-06-20 |
| Owner |
INTHERA BIOSCIENCE AG (Switzerland)
|
| Inventor |
- Kessler, Ulrich
- Cattori, Valentino
- Cook, Cyril
- Vakiti, Ramkrishna Reddy
- Johnson, Kevin R.D.
|
Abstract
The present invention relates to novel compounds of formula (I) or formula (Ia), pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
IPC Classes ?
- C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C07D 471/04 - Ortho-condensed systems
- C07D 471/10 - Spiro-condensed systems
- C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- C07D 495/04 - Ortho-condensed systems
- C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D 491/20 - Spiro-condensed systems
- C07D 495/10 - Spiro-condensed systems
- C07D 497/10 - Spiro-condensed systems
- A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61P 35/00 - Antineoplastic agents
|
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