Exemplary systems and methods associated with activating fluids using indirect plasma. In particular, liquid can be activated to high concentrations and at high volumes by thinning and mixing the liquid as it is exposed to the plasma, resulting more efficient activation. Further increases in activation can be reached by re-circulating fluid for additional exposure to the plasma. High flow rates can be achieved with integrated systems that utilize multiple activation systems with coordinated control.
Exemplary systems and methods associated with trans-tissue substance delivery using non-thermal plasma to porate skin or tissues using contoured dielectrics/electrodes and grounding techniques. In some embodiments, a substance delivery system may be incorporated into the plasma generating device for automatically controlled skin treatments. In other embodiments, a skin treatment patch may include the electrode and the treatment substance.
Apparatuses (201, 301, 401, 501, 601, 701, 801, 901) for delivering bioactive substances or cosmetic substances using plasmaporation and microneedles are provided. The delivery of the substances includes topical, intracellular, intercellular, and transdermal delivery to the subject.
Exemplary systems and methods associated with skin treatments using non- thermal plasma to porate skin or tissues using conductive elements to direct an electric field through targeted regions of the skin or tissue. Various configurations of conductive elements and associated circuitry may be used to tune and control the electric field.
Exemplary methods and systems for killing or deactivating spores include applying a fluid containing an additive to a surface containing a spore; and applying direct or indirect plasma to the surface for a period of time.
A subject's skin is exposed to non-thermal plasma, thereby enabling analytes in the interstitial fluid in the subject's body to migrate to the surface of the subject's skin. The concentration of analytes in the subject's blood can be determined based on the amount of these analytes.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
7.
METHOD AND SYSTEMS FOR CREATING LARGE VOLUMES OF HIGHLY CONCENTRATED PLASMA ACTIVATED LIQUID USING COLD PLASMA
Exemplary embodiments of systems for generating large volumes of plasma activated liquids are disclosed herein. An exemplary system for creating a large volume of plasma- activated liquid includes a gas pump that moves a gas and liquid entrained in the gas, one or more plasma generators for generating plasma to activate at least one of the gas and the liquid entrained in the gas, a supply of liquid to be activated, a liquid aerator for creating an aerated liquid to be entrained in the gas, an activation chamber for activating the aerated liquid by contacting at least one of the aerated liquid or aerated liquid entrained in gas with plasma or plasma activated gas to form an activated liquid gas mixture. The exemplary system also includes a liquid gas separator positioned downstream of the activation chamber. The liquid gas separator separates at least a portion of the activated liquid gas mixture into an activated liquid and the gas. The activated liquid flows out of a first portion of the liquid gas separator and the gas flows out of a second portion of the liquid gas separator.
The nutrient rich water which is sprayed onto the roots of a plant being grown aeroponics or hydroponics is plasma-activated water generated by a non-thermal plasma.
Exemplary methods of and system for generating an antimicrobial wipe to clean and disinfect a surface contaminated with bacteria, viruses, spores, fungi, or combinations thereof. In some embodiments, the method includes applying non-thermal plasma to a moistened wipe to activate a liquid in the wipe. In some embodiments, the method includes applying non-thermal plasma to a liquid and then applying the activated liquid to a wipe. In one embodiment of a system for generating an antimicrobial wipe the system includes a housing having an opening; a supply of wipes disposed within the housing; a non -thermal plasma generator disposed within the housing; a power supply electrically coupled to the non-thermal plasma generator; and a feed system disposed within the housing, wherein the feed system moves one or more wipes from the supply of wipes past the plasma generator and out of the opening. As the feed system moves the wipes past the plasma generator, the plasma generator applies non-thermal plasma to the wipes.
A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
A cleaning, sanitizing or disinfecting scrubbing device includes a body, a non-thermal plasma generator and damp wipe. Generated plasma activates fluid in the wipe. The device may include spacer posts between the body and wipe and a conductive mesh between the body and wipe or embedded in the wipe. Another embodiment includes a reservoir for holding a water- based fluid, a fluid delivery element connected to the reservoir by a tube through which the fluid can flow and a non-thermal plasma generator. The non-thermal plasma generator activates the fluid. In one embodiment the scrubbing device is a mitt. In another embodiment the scrubbing device is a glove.
C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
D06M 10/02 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements ultrasonic or sonicCorona discharge
System and method for printing a three-dimensional object include a 3D printing device (100) and a plasma applicator (102). In some embodiments the plasma applicator is rotatably connected to the 3D printing device and may apply plasma to a molten layer of 3D printing material immediately after the material is laid, or to a solidified layer immediately before the next layer is laid. In some embodiments a second plasma applicator is included for application of plasma both before and after each layer. In some embodiments plasma is applied to the final layer of a finished 3D printed object.
Exemplary apparatuses and methods of killing or deactivating bacteria are disclosed herein. An exemplary apparatus for killing or deactivating bacteria includes a plasma vapor chamber. The plasma vapor chamber has a vapor inlet for allowing a vapor into the chamber, a high voltage electrode, one or more grounding electrodes. The one or more grounding electrodes at least partially surrounding the plasma vapor chamber. The plasma vapor chamber includes an outlet for allowing fluid to flow out of the chamber. When the chamber is filled with vapor for a period of time sufficient to saturate the chamber with vapor, the high voltage electrode is energized to generate plasma throughout the chamber.
Exemplary methods of improving the delivery of a substance encapsulated in a delivery vehicle to cells of interest in skin, tissue or tumor are disclosed herein.
A medical device for directly applying DBD plasma includes a plasma generation module having an electrode surrounded by a dielectric barrier. In one embodiment, when a high voltage source is applied to the electrode, plasma is produced from ambient gas on an outside surface of the plasma generation module. In another embodiment, an enclosure is deployed around the distal end of the plasma generation module surrounding the electrode. Gas flows past the electrode and into the enclosure. In some embodiments, some or all of the gas is removed or pumped out of the enclosure by suction/vacuum. When a high voltage source is applied to the electrode, plasma is produced using the gas flowing into the enclosure.
A treated crop plant or plant food product with decreased bacterial viability relative to an untreated crop plant or plant food product. The treated crop plant or plant food product has at least a 1-log reduction in bacterial viability relative to the untreated crop plant or plant food product. Methods and apparatuses of producing the treated crop plant or plant food product are also provided.
A01N 3/00 - Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leavesGrafting wax
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
A23B 7/015 - Preserving by irradiation or electric treatment without heating effect
A23B 9/06 - Preserving by irradiation or electric treatment without heating effect
Plasma treatment devices for reducing bacterial viability, enhancing stem growth, enhancing root growth or increasing germination times are disclosed herein. In addition, a treated sprout plant treated with a plasma activate medium or plasma with decreased bacterial viability relative to an untreated sprout plant. The treated sprout plant has at least a 1-log reduction in bacterial viability relative to the untreated sprout plant. Methods and apparatuses of producing the treated sprout plant are also provided.
A23L 3/26 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
A01G 7/04 - Electric or magnetic treatment of plants for promoting growth
B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
A01C 1/02 - Germinating apparatusDetermining germination capacity of seeds or the like
Exemplary methods of treating tissue that has been harvested for transplant are disclosed herein. An exemplary method of preparing corneal tissue for transplant includes obtaining corneal tissue that has been harvested for transplanting and exposing the corneal tissue to a plasma-activated fluid for a period of time.
An exemplary method of delivering drugs or vaccines includes applying a series of first electrical signals to an electrode to generate plasma. The first electrical pulses having a first duration, first voltage amplitude, and first rise time. Applying molecules, drugs or vaccines to an area of skin contacted by the plasma; and applying a series of second electrical signals to the electrode to generate plasma to contact the area of the skin. The second electrical pulses have a second duration, second voltage amplitude, and second rise time. The duration for the first electrical pulses is shorter than the duration for the second electrical pulses. The voltage amplitude of the second electrical pulses is larger than the first electrical pulses. The rise time of the second electrical pulses is shorter than the first electrical pulses.
Exemplary embodiments of shape conforming dielectric barrier discharge (DBD) plasma generators are disclosed herein. One exemplary embodiment includes a flexible pad and a plurality of electrodes located in the pad within close proximity of each other, and a flexible dielectric barrier surrounding the plurality of electrodes and separating the plurality of electrodes from each other. Wherein when a high voltage pulse is applied to one or more of the plurality of electrodes, plasma is produced between a surface of the flexible pad and a portion of the body in close proximity to the flexible pad.
Exemplary systems and methods of delivering DNA vaccines are disclosed herein. An exemplary methodology of delivering DNA vaccines includes providing a plasma generator for applying plasma to a treatment area for a sufficient period of time to open one or more pores. Applying a topical DNA vaccine to the treatment area and waiting for a period of time to allow the DNA vaccine to travel through the one or more pores. The exemplary methodology further includes applying plasma to the treatment area at a setting sufficient to cause intracellular uptake of the DNA vaccine.
Exemplary methods of opening pores and moving molecules into tissue comprising, applying plasma to the surface of tissue and applying a carrier including one or more molecules to the surface of the tissue are disclosed herein.
Exemplary methods for killing or deactivating bacteria are provided herein. One exemplary method includes providing a plasma system and a filter below the plasma system. Energizing the plasma generator to create indirect plasma downstream of the filter and activating a fluid with the indirect plasma and applying the activated fluid to bacteria is shown to deactivate and kill bacteria.
C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
Exemplary methods and systems for killing or deactivating spores include applying a fluid to a surface containing a spore; and applying direct or indirect plasma to the surface for a period of time. In some embodiments, the fluid includes water. In some embodiments, the spore is Clostridium difficile and in some is Bacillus Anthracis. In some embodiments, the fluid is in the form of a vapor, a fog, a spray, a mist or an aerosol, which may be activated prior to or after applying the fluid to a surface. In some embodiments, peroxynitrite is created in the fluid during the method. Another exemplary embodiment of killing or deactivating a spore includes treating spores with direct plasma or indirect plasma for a period of time and applying an antimicrobial to the spores. In some embodiments, the antimicrobial is an alcohol, a bleach or an alcohol-based sanitizer.
Exemplary embodiments of solutions of plasma activated water and peroxyacetic acid are disclosed herein. In addition, exemplary embodiments of methods for making solutions are disclosed herein. Some methods include exposing water to a plasma gas to activate the water, adding acetic acid to the activated water; and mixing the acetic acid and activated water to form a solution. Additional exemplary methods include adding acetic acid to water to form a solution, mixing solution of acetic acid and water together; and exposing the solution to a plasma gas to activate the solution. Another exemplary embodiment includes exposing water to a plasma gas to activate the water; adding an acetyl group donor to the activated water; and mixing the acetyl group donor and activated water to form a solution.
A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
A01N 37/16 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group Thio-analogues thereof
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
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