A classification device for classifying an input signal which is an aperiodic vibration signal, includes a vibratory network and a support. The vibratory network includes a set of vibratory elements and a set of coupling elements that couple the vibratory elements together and to the support, which supports the network. The input signal is classified to be a trigger signal or to be a signal other than a trigger signal depending upon whether a magnitude related to one of the vibratory elements referred to as triggering element is greater than or less than a threshold value. The magnitude is one of a displacement, a velocity, or an acceleration of the triggering element. The switching device includes a classification device and a switching element operationally connected to the classification device, to change a switching state of the switching element when the magnitude reaches or exceeds the threshold value.
The present invention relates to an improved porous solid catalyst (C) adapted for the conversion of methanol and derivatives thereof into low-molecular weight hydrocarbons, based on a zeolite, such as ZSM-5, and on inorganic oxide, such as ceria, in a preferable weight ratio of zeolite:inorganic oxide between 1:1 and 1:5. It further relates to a conversion process and to a system using such a catalyst.
B01J 38/12 - Treating with free oxygen-containing gas
C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
C10G 3/00 - Production of liquid hydrocarbon mixtures from oxygen-containing organic materials, e.g. fatty oils, fatty acids
C07C 1/20 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms
B01J 23/92 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides provided for in groups
B01J 29/70 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of types characterised by their specific structure not provided for in groups
3.
DEVICE AND METHOD FOR ELECTRICALLY STIMULATING AT LEAST ONE NERVE
A device for electrically stimulating at least one nerve. The device comprises a bendable substrate configured to be arranged at least partially surrounding the nerve so as to define an inner surface of the substrate that faces an outer surface of the nerve. At least two electrodes, whereby at least one of the electrodes is a surface electrode and at least one of the electrodes is an intraneural electrode, each being arranged on the inner surface of the substrate. At least one surface electrode is configured to establish an electric connection with a part of the nerve on the outer surface of the nerve. At least one intraneural electrode is configured to penetrate the outer surface of the nerve to establish an electric connection with a part of the nerve within the nerve. A method for electrically stimulating at least one nerve is also provided.
The present disclosure provides a mucosal suction patch comprising at least one bulb containing a drug; the at least one bulb having an elasticity such that, upon applying mechanical pressure on a pressure applying surface of the patch, the at least one bulb is deformed, and when the mechanical pressure is released while the patch sealing surface is on a subject mucosa, the at least one bulb at least partially regains its expanded state, which in turn deforms the mucosa, which reversibly fills up at least part of the at least one bulb cavity, causing the drug to migrate in the mucosa. It also provides uses of the patch for the transmucosal delivery of a drug in a subject. This patch enables a non-invasive, non-parenteral systemic administration of drugs, particularly macromolecular drugs.
The present invention is directed to composition comprising modified DNA identifier sequences (MoDIS) comprising (i) a validation code nucleotide sequence (VC), (ii) a randomized index code nucleotide sequence (RIC) and (iii) an annealing site nucleotide sequence (AS) for specifically binding a primer for PCR amplification, wherein (a) AS is attached to an affinity tag or marker and/or affinity tag compound for the identification, enrichment and/or purification of MoDIS-bound nucleotide sequences; and (b) the nucleotide at the 5'-end of the MoDIS comprises a 5'- azido-modified moiety or a 5'-alkynyl-modified moiety.
The present invention relates to a separation process for rare earth element compounds by converting a mixture of rare earth element compounds into novel thiometallate complexes which exhibit substantially different structures and thus solubility depending on the rare earth metals employed in said process and their state of oxidation. The invention further encompasses the thiometallate complexes as such.
C01F 17/10 - Preparation or treatment, e.g. separation or purification
C01F 17/17 - Preparation or treatment, e.g. separation or purification involving a liquid-liquid extraction
C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions
C22B 3/26 - Treatment or purification of solutions, e.g. obtained by leaching by liquid-liquid extraction using organic compounds
C22B 3/38 - Treatment or purification of solutions, e.g. obtained by leaching by liquid-liquid extraction using organic compounds containing phosphorus
The invention relates to a chimeric antigen-receptor polypeptide heterodimer comprising two polypeptides, wherein the first contains an extracellular part of the major histocompatibility complex I alpha chain and the second contains a β2-microglobulin domain, or the first contains an extracellular part of the major histocompatibility complex Il alpha chain and the second contains a major histocompatibility complex Il beta chain. One of the polypeptides further contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor alpha chain and the other one contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor beta chain, and additionally an antigen-peptide covalently linked to said extracellular MHC domain. The invention further relates to a method for the identification of a TCR recognizable peptide sequence making use of the heterodimer of the invention.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (Switzerland)
ETH ZURICH (Switzerland)
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
Inventor
Benea-Chelmus, Ileana-Cristina
Loncar, Marko
Faist, Jerome
Tomasino, Alessandro
Shams-Ansari, Amirhassan
Herter, Alexa
Lampert Almahmoud, Yazan
Abstract
A terahertz device for detecting or emitting or for both detecting and emitting electromagnetic waves in the terahertz frequency range. The terahertz device comprises: a first waveguide branch and a second waveguide branch, the first and second waveguide branches being configured to allow optical signals to propagate through them, the first and second waveguide branches being nonlinear dielectric elements with a thickness of at most 500 micrometres; and an antenna arrangement comprising a set of antennas for capturing and/or emitting electromagnetic waves in the terahertz frequency range, the antennas being placed along at least one of the waveguide branches in an immediate vicinity of the respective waveguide branch and/or around the respective waveguide branch to at least partially enclose the respective waveguide branch in a respective antenna gap of the respective antenna.
The invention is notably directed to a composition including a plurality of double-stranded oligodeoxynucleotides (dsODNs). The dsODNs of said plurality have a same length of between 47 and 300 bp (e.g., between 80 and 150 bp, or between 85 and 130 bp). The dsODNs are structured according to a same template structure, which consists of an orderly set of sequence portions having respective lengths that are constant across all the dsODNs of said plurality. The orderly set of sequence portions includes a first random segment, a first sequencing adapter, a second random segment, a second sequencing adapter, and a third random segment. Such segments are consecutively arranged to form a sequence. Each of the random segments of the dsODNs of said plurality consists of essentially random permutations of nucleotides, whereas the first and second sequencing adapters of the dsODNs of said plurality consist, independently of each other, of essentially a same sequence of nucleotides. The above template structure gives rise to partly random DNA, which can be operated for verification and/or authentication purposes. The above sequence structure allows the composition to be used as a mathematical one-way function and as a physical unclonable function (PUF). I.e., it can be used as a physical fingerprint, which can be challenged to verify or authenticate a product, an object, or any entity, with which the composition is associated. The same composition can be subjected to multiple challenges, hence providing higher certainty as to an associated entity. The underlying technology is scalable. Samples of the composition can be distributed to multiple users, unlike usual PUF objects. Accordingly, the proposed composition can adequately be used for securing objects or entities. The invention is further directed to methods of producing such a composition, the use of such a composition, a set comprising such a composition associated with an entity, and methods of verifying entities associated with such compositions.
Ex vivo tissue culturing and sampling system (2) comprising a microfluidic cartridge (4) and a microfluidic sampling apparatus (3) that receives the microfluidic cartridge and a tissue support substrate (5) on which a tissue sample (1) to be cultured and analysed is mounted, the tissue support substrate separable from the microfluidic cartridge and comprising a porous hydrophilic membrane (19), the microfluidic cartridge comprising - a body (10), - a reaction chamber (20) formed within the body and configured to be sealingly closed by a seal (24) around the tissue sample (1) on the tissue support substrate (5), and - a transparent observation window (16) bounding one side of the reaction chamber configured to allow microscope imaging of the tissue sample, the microfluidic sampling apparatus comprising - a cartridge holder (6) in which the microfluidic cartridge and biological sample support substrate is removably mounted, - a reagent fluid flow system (7) configured to pump liquid through the microfluidic cartridge reaction chamber, and - a gas to liquid diffusion device (8) connected to the reagent fluid flow system upstream of the microfluidic cartridge reaction chamber.
A microelectrode device (1) for sensing a biological activity within a sample (S), the microelectrode device (1) comprises an electrode assembly (11) with electrodes (11.1, 11.2; 11.r, 11.c) for contacting the sample (S), and an electronic equipment (12) which is connected to the electrodes (11.1, 11.2; 11.r, 11.c) of the electrode assembly (11). The electronic equipment (12) is configured to evaluate one or more capacitances (C; C0, C1,...) between the electrodes (11.1, 11.2; 11.r, 11.c) for sensing the biological activity within the sample (S). The microelectrode device (1) enables that the one or more capacitances (C; C0, C1,...) include one or more electrical double layer capacitances (C_EDL) of one or more electrical double layers which are formed when the electrodes (11.1, 11.2; 11.r, 11.c) are brought into contact with the sample (S).
EMPA EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (Switzerland)
ETH ZÜRICH (Switzerland)
Inventor
Jessernig, Alexander
Herrmann, Inge Katrin
Anthis, Alexandre Herrmann Christos
Abstract
The present invention relates to the use of a biosensor to detect a postoperative leak with a patient's drain fluid, relating to an operation selected from the group consisting of pancreatic anastomosis, pancreatic resection, small colon anastomosis (also called small intestine anastomosis), large intestine anastomosis, colorectal surgery, colon bypass surgery, gastric bypass surgery, gastric resection surgery, cholecystectomy, bileduct surgery and oesophageal surgery, and wherein said biosensor comprises at least one gel which is placed on a support layer, and wherein the at least one gel is sensitive to a digestive enzyme and comprises a colorant selected from the group consisting of an organic dye, an inorganic dye, an organic pigment and an inorganic pigment, and wherein said at least one gel degrades upon contact with a drain fluid comprising one or more digestive enzymes, allowing a visual detection of discoloration of the gel or disappearance at the place where the gel was before, and/or a coloration of the drain fluid.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
A photodetector (8) comprises: a multilayer stack comprising a resonator layer (1) which is in contact with a 2D material layer (3) which is in contact with an insulator spacer layer (4), wherein the multilayer stack is configured to absorb an optical signal and to convert the absorbed optical signal into charge carriers and to enable electrically measuring the charge carriers, wherein the 2D material layer (3) includes one or more layers of a 2D material, wherein the resonator layer (1) comprises first and second contact lines (1a1, 1a2) which have an alternating configuration, wherein the first and second contact lines (1a1, 1a2) include different materials, wherein at least one of the first and second contact lines (1a, 1a2) has arranged resonators (1b, 1b1, 1b2, 1bb, 1bb1, 1bb2, 1bbb).
H01L 31/028 - Inorganic materials including, apart from doping material or other impurities, only elements of Group IV of the Periodic System
H01L 31/036 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their crystalline structure or particular orientation of the crystalline planes
H01L 31/102 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
H01L 31/0232 - Optical elements or arrangements associated with the device
14.
CULTIVATION MEDIUM AND METHOD OF CULTIVATING MICROALGAE
The present invention relates to a cultivation medium, a method of preparing a cultivation medium and a method of cultivating heterotrophic microalgae. The cultivation medium comprises a mixed hydrolysate medium containing 15% to 25% v/v soy whey hydrolysate and 75% to 85% v/v brewer's spent grain hydrolysate, based on the total volume of the mixed hydrolysate medium, wherein the cultivation medium is rich in endogenous glucose, having an endogenous glucose density of 46.0 to 51.0 g/L, for supporting growth of heterotrophic microalgae. The method of the present invention yields relatively high amount of microalgal biomass and provides increased biomass production.
A method for collecting environmental DNA from a space (101) within a plant canopy (100) comprises: providing a UAV (1) comprising a propulsion system (2) and a probe (3) hanging from the propulsion system (2); providing the probe (3) with a sampling material (5); flying the UAV 5 (1) with the propulsion system (2) at a height (H) over the plant canopy (100); dipping the probe (3) into the plant canopy (100); brushing the sampling material (5) against a plant surface (102) in the space (101) within the plant canopy (100); and extracting the probe (3) from the plant canopy (100).
The invention relates to a method for isolating a biomolecule. A liquid sample comprising the biomolecule is contacted with an electrically conductive surface. The surface carries a chemical modification facilitating retention of said biomolecule, or an electrical retention potential is applied to said surface. The biomolecule is released by applying a voltage to the surface. The invention further relates to a device comprising a chamber configured for receiving a liquid sample, wherein a first surface of said chamber is a working electrode formed by a high-surface, electrochemically active material embedded in a non-electrically conductive polymer matrix. The device further comprises a counter electrode and connections to a voltage source. The invention further relates to a device and method for loading an extracellular vesicle with cargo molecules.
G01N 33/554 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
H03L 7/093 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal using special filtering or amplification characteristics in the loop
H03L 7/197 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop using a frequency divider or counter in the loop a time difference being used for locking the loop, the counter counting between numbers which are variable in time or the frequency divider dividing by a factor variable in time, e.g. for obtaining fractional frequency division
18.
Extrusion System and Method for Obtaining a Meat Analogue
Provided is an extrusion system including an extruder and a die. The die includes a feed section with at least two ports for injecting a protein phase and/or fat phase, a feed channel, an extrusion plane with side walls and a die exit. Each of the ports is connected to an independent channel providing the protein phase and/or fate phase. The at least two ports lead into the feed channel. The feed channel leads to the extrusion plane such that the protein phase and/or fat phase is conveyed from the feed section to the extrusion plane. The extrusion plane has an isosceles triangular shape with the legs of the triangle forming the side walls and the base of the triangle forming the die exit. The feed channel leads into the extrusion plane at the apex of the triangle of the extrusion plane.
Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.
An encoder is trained to generate latent representations of kinematic motion from motion data and a control policy is trained to generate dynamics informed output for a robotic system based on the latent representations of kinematic motion. The encoder and the control policy are deployed in the robotic system to generate the dynamics informed output based on the motion data.
The invention relates to a CjCas9 variant characterized by at least one of the mutations E789K and S951G. The invention further relates to base editing enzymes comprising the Cas variant according to the invention and an adenosine deaminase activity, and to polynucleotides encoding same.
The invention relates to a compound of formula (I)
The invention relates to a compound of formula (I)
wherein A1, A2, X and R1—R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
23.
NEW CORONAVIRUS VACCINE AND METHOD FOR DESIGNING AND OBTAINING A VIRUS VACCINE
The present invention relates to a mutant receptor-binding domain (mRBD) of a coronavirus (mRBD-CORONA) or a fragment thereof and mutant spike protein of the coronavirus (CORONA-mSpike) or a fragment thereof comprising the CORO-NA-mRBD or the fragment thereof. Furthermore, the present invention relates to a polypeptide or protein comprising the mRBD-CORONA or the fragment thereof or CORONA-mSpike or the fragment thereof and a nucleic acid comprising a nucleotide sequence encoding for the mRBD-CORONA or the fragment thereof or the CORONA-mSpike or the fragment thereof. Furthermore, the present invention relates to a vaccine composition comprising one or more CORONA-mRBDs or fragments thereof, one or more CORONA-mSpikes, one or more polypeptides or proteins and/or one or more nucleic acids according to the present invention. Furthermore, the present invention relates to the one or more CORONA-mRBDs or fragments thereof, the one or more CORONA-mSpikes, the one or more polypeptides or proteins, the one or more nucleic acids and/or the vaccine composition according to the present invention for use in the prevention and/or treatment of diseases caused by coronaviruses in a subject. Furthermore, the present invention relates to a method for designing and/or obtaining an active ingredient for a vaccine composition and to a VIRUS-mRBD or a fragment thereof designed and/or obtained by the method for obtaining the VIRUS-mRBD according to the present invention.
A patch for detecting by at least one non-invasive imaging technique a leak of a biological fluid at an application site, wherein the patch includes either a layer including one or more first portions containing a first gel, one or more second portions containing a second gel and at least one sensing component embedded within the first gel and/or the second gel, or a layer containing a hydrogel and at least one sensing component, such as aerogel particles, and xerogel particles, embedded within the hydrogel.
One or more transmitters (TX1, …, TXU; TX) and a receiver (RX) of a MIMO communication system (1) enable mitigation of a jammer (TXJ). The one or more transmitters (TX1, …, TXU; TX) are configured to generate an embedded signal (X) by embedding a transmit signal (S) with a linear time-domain transformation onto a secret subspace (subC) based on a secret unitary matrix (C; C1, …, CU) which is accessible to the transmitters (TX1, …, TXU; TX) and the receiver (RX), and to transmit the embedded signal (X) via MIMO communication having a legitimate channel matrix (H) to the receiver (RX). The receiver (RX) is configured to receive a receive signal (Y) which includes the embedded signal (X) and to process the receive signal (Y) for determining an estimate (~S) of the transmit signal (S) by extracting the transmit signal (S) from the secret subspace (subC) using the secret unitary matrix (C; C1, …, CU).
The present invention relates generally to a method for producing organoids, and more specifically to a method for producing human retinal organoids. The present invention further relates to a method for the automated generation of mammalian retinal organoids comprising continuous in vitro culturing of pluripotent stem cells and descendants thereof, which allows for the reproducible and efficient generation of human retinal organoids in large numbers. The invention further relates to producing organoids from stem cells that are derived from humans or other mammals that are healthy or have a disease. The present invention also relates to compositions and methods for the assessment of drug toxicity, efficacy, and other therapeutic agent properties or for the treatment of retinal diseases or for retinal organoid protocol development. The organoids of the invention are useful for the treatment of retinal diseases, for medical or biomedical assays, and as diagnostic tools for screening drugs or other compounds or developing therapeutic treatments for retinal diseases.
Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Instructional and teaching material; manuals for training
purposes; printed matter; books. Training; continuous training; continuing training services;
providing information on ongoing training via the Internet;
secondary, university, linguistic and professional training
and teaching; education and training advice in the field of
management and personnel; coaching; training and teaching
services; organizing and conducting conferences, congresses,
seminars and workshops (training); organizing and conducting
conferences, congresses, seminars, symposiums, training,
teaching and presentations; sporting and cultural
activities, electronic publishing; editing publications by
means of electronic media; on-line providing of electronic,
non-downloadable publications; publication of training
manuals; editing services. Scientific and technological services and research and
development services relating thereto; scientific and
technological services and research and design services
relating thereto.
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA (Switzerland)
Inventor
Deshmukh, Dhananjay
Tibbitt, Mark
Dual, Jürg
Weder, Gilles
Vuille-Dit-Bille, Emilie
Abstract
It is thus a first object of the present invention to provide a process for the production of a microtome block comprising biological samples, wherein in said microtome block, the biological samples are concentrated in one plane and which biological samples are concentrated in said plane via acoustofluidic methods.
A method for detecting and/or characterizing a ligand-target binding based on photochemically induced dynamic nuclear polarization (photo-CIDNP) enhanced NMR spectroscopy, comprising the steps: (a) irradiating a sample (A) comprising a photosensitizer and a ligand to excite the photosensitizer and induce dynamic nuclear polarization of the ligand by the photosensitizer, (b) recording an NMR spectrum of sample (A), repeating steps (a) and (b) with a sample comprising sample (A) and further comprising a target of interest, and (c) comparing the NMR spectra of samples (A) and (B) and detecting and/or characterizing a ligand-target binding based on at least one difference in the NMR spectra. The present invention further pertains to a device for conducting the method.
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
G01N 1/14 - Suction devices, e.g. pumpsEjector devices
An apparatus for emitting electromagnetic radiation includes a gain element, an optical arrangement defining a resonator and arranged to re-direct radiation emitted by the gain element along a beam path back onto the gain element, the optical arrangement including an output coupler configured to couple a portion of the radiation in the resonator out of the resonator, and a pump arrangement configured to pump the gain element. The optical arrangement further includes a passive device placed in the resonator in the beam path, the passive device having at least two surface portions at an angle to each other. The passive device is arranged to direct first radiation portions and second radiation portions of the radiation, which first and second radiation portions are incident on different ones of the surface portions, to be spatially separated. The apparatus is suitable as a source of dual-comb pulsed laser radiation.
A logic circuit, comprises at least two transistors which are configured for providing a logic function, and at least one voltage-controlled threshold switch, which is arranged in at least one of the pull-up path and the pull-down path of at least one of the at least two transistors.
H03K 19/00 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits
H03K 19/094 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using semiconductor devices using field-effect transistors
H03K 19/173 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using elementary logic circuits as components
H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits
H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching
H10N 70/20 - Multistable switching devices, e.g. memristors
33.
METHOD FOR THE ADDITIVE MANUFACTURING OF CASTING MOLDS
A method for manufacturing a photopolymerizable slurry comprises the steps of: providing a plurality of particles of an inorganic salt in the form of a powder; wherein at atmospheric pressure the inorganic salt has a melting point of above 250° C.; and wherein at room temperature the inorganic salt has a solubility in water above 9% w/w; providing at least one radiation curable monomer; the at least one radiation curable monomer being in the liquid phase; and adding the inorganic salt particles to the liquid composition and mixing the inorganic salt particles with the liquid composition; obtaining a photopolymerizable slurry, selectively curing the photopolymerizable slurry to obtain a green body article; debinding the green body article to obtain a binderless body article; and sintering the binderless body article to obtain a sintered ceramic article; providing a first template mold (1); wherein the first template mold comprises the sintered ceramic article; providing a second mold (2, 2′, 2″); wherein the second mold comprises a compartment into which said first template mold can be placed; mounting the first template mold into the compartment of the second mold, thereby obtaining an operative mold (1, 2, 2′, 2″); casting a fluid casting material (3, 3′, 3″) into said operative mold to obtain after solidification of said casting material an infiltrated template mold (8) comprising a solid article (9) that is at least partially located within the first template mold (1); and separating said solid article from the first template mold by dissolving the sintered ceramic article of the first template mold with a suitable solvent, for example water.
B22C 9/10 - CoresManufacture or installation of cores
B22C 1/10 - Compositions of refractory mould or core materialsGrain structures thereofChemical or physical features in the formation or manufacture of moulds characterised by additives for special purposes, e.g. indicators, breakdown additives for influencing the hardening tendency of the mould material
B22D 18/06 - Vacuum casting, i.e. making use of vacuum to fill the mould
B22D 29/00 - Removing castings from moulds, not restricted to casting processes covered by a single main groupRemoving coresHandling ingots
B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
B29C 33/52 - Moulds or coresDetails thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles soluble or fusible
B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
B33Y 80/00 - Products made by additive manufacturing
C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
C09D 11/107 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from unsaturated acids or derivatives thereof
34.
Cell line for TCR discovery and engineering and methods of use thereof
The present invention is in the field of immunology and provides a cell line for the discovery and engineering of T cell receptors. The invention further provides methods for the discovery of antigen-specific T cell receptors and for the engineering of T cell receptors with optimized antigen-binding and antigen-induced signaling properties.
Systems and methods are provided to provide a prediction for a physiological parameter of a patient to a clinical decision support tool. For that purpose, a real-time or near real-time data stream is accessed of measured values of a physiological parameter of a patient. A trained machine learning model is used to generate, using a time-series of measured values from the real-time or near real-time stream as input, a time-series of predicted values as output. It is determined whether predicted values fall within a physiological range associated with the physiological parameter, thereby obtaining a time- series of classifications, wherein a respective classification is indicative of whether a predicted value falls inside or outside of the physiological range. The time-series of classifications provided to the clinical decision support tool, for example to visualize the time- series of classifications in a graphical representation of a patient's medical condition.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
The present invention relates to a compound of formula (I)
The present invention relates to a compound of formula (I)
The present invention relates to a compound of formula (I)
wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07B 59/00 - Introduction of isotopes of elements into organic compounds
37.
DEVICE AND METHOD FOR ARRANGEMENT ON A BODY COMPRISING AN ESSENTIALLY ROTATION-SYMMETRIC PORTION, AND METHOD FOR MOVING AND/OR MANIPULATION OF AN OBJECT USING THE DEVICE
A device for arrangement on a body comprising an essentially rotation-symmetric portion. The device comprises at least one interface that comprises two clamps with at least one pivot axis, each clamp comprising a clamp tip, the respective clamp tip being arranged opposite of the at least one pivot axis and the pivot axis being arranged fixed in relation to a base structure comprised by the device. The clamps are configured to be pivoted around the at least one pivot axis between a first position and a second position, respectively, wherein in the first position, the clamp tips are spaced further from each other than in the second position. A support structure is arranged between the clamps. A support rope system has at least one support rope, with at least one support rope of the rope system being connected to a tensioning element fixed with respect to the base structure.
A kit of parts including two components, the first component being a patch including a non-degradable synthetic hydrogel and the second component being an impregnating fluid, which, upon in-situ polymerisation, anchors the patch on a tissue. The patch may include additional layers including sensing components or therapeutic components. In addition, the use of the kit of parts and the use of an impregnating fluid in surgery, in particular as suture or staple supports, e.g. suture or staple supports in the abdominal region such as intestinal anastomosis sites, or for sealing of artificial stoma.
The present invention relates to a digital transaction between a sender (S) and a recipient (R), wherein the digital transaction is certified by a central bank (B), while preserving the privacy of the transaction (T). In particular the transaction (T) is based on a first sender serial number (SSNi) and a first receiver serial number, both signed by the central bank (B) and dedicated to the transaction. The transaction is in addition based on commitment to a value, which is encrypted with a blind factor (BTx) and involves sender zero-knowledge proof (zKs) and receiver zero-knowledge proof (zKr) so that the central bank (B) has no knowledge of the value of the transaction neither of the identity of the sender and the receiver. The present invention also relates to a system and to a digital currency allowing such a digital transaction.
G06Q 20/40 - Authorisation, e.g. identification of payer or payee, verification of customer or shop credentialsReview and approval of payers, e.g. check of credit lines or negative lists
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
40.
SHEAR THINNING TWO-PHASE COMPOSITION AND PRODUCTS MADE THEREOF
EMPA EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT (Switzerland)
ETH ZÜRICH (Switzerland)
Inventor
Danner, Patrick Marcel
Opris, Dorina Maria
Pleij, Tazio
Bayles, Alexandra Victoria
Vermant, Jan
Abstract
The present invention pertains to a shear thinning two-phase composition based on polysiloxanes and a filler. The invention is further directed to associated methods of manufacturing the composition, to the use of the composition as an ink and to products made from the composition.
C08J 3/05 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
41.
APPARATUS AND METHOD FOR LEAKAGE REDUCTION IN A QUANTUM COMPUTING DEVICE
An apparatus comprises a qubit (100), a resonator structure (200) coupled to the qubit, and a frequency-modulation device (300) coupled to the qubit. For converting leakage errors into errors in the computational subspace, the frequency modulation device applies a frequency modulation pulse to the qubit, which causes periodic modulation of the qubit frequency. The frequency modulation pulse is applied in such a manner that population transfer between a leakage state and the first excited qubit state is facilitated while population transfer between the computational states of the qubit is suppressed.
In a method for analyzing cells, a sample fluid having a suspending medium and cells is fed to a microfluidic device having at least one cell processing unit having a trapping region, a reaction unit, and an outlet arrangement. The trapping region is delimited by at least an input valve and a sieve valve, in particular a v-type valve that is capable of retaining the cells while letting fluids pass. The method includes trapping cells in the trapping region, subsequently establishing a flow of a reaction fluid through the trapping region while the sieve valve assumes the open state, such that the reaction fluid transfers the trapped cells from the trapping region into the reaction unit, decomposing the transferred cells into cell fragments through a decomposition process, collecting the cell fragments in the outlet arrangement, and analyzing the cell fragments.
The present disclosure relates to a method for producing calcium carbonate solids from alkaline minerals including the following method steps: Supplying alkaline minerals and an extraction agent into a reactor tank. Stirring the alkaline minerals and the extraction agent in the reactor tank such that a first suspension is formed. Draining of the first suspension from the reactor tank and separating a liquid phase comprising calcium from the first suspension and transferring the liquid phase into a carbonation tank. Supplying a gas comprising CO2 into the carbonation tank, wherein the consumption of CO2 results in the precipitation of calcium carbonate solids thereby generating a second suspension and nucleating and growing of the calcium carbonate solids. Furthermore, a measure of the consumed CO2 is determined by at least one sensor.
The present invention relates to a time-continuous neural network circuit implemented on analog hardware with device mismatch, the circuit including a control unit (40) which is individually connected to each respective neuron of the circuit, the neurons in the hidden and output layers comprising a forward compartment for processing signals coming from preceding layers, a feedback compartment for processing feedback signals coming from the control unit and a central compartment for generating and sending a signal to the next layer or to the control unit. The control unit generates and sends to the feedback compartment of each respective neuron a feedback signal (Sf) based on the comparison between a network output signal (Sout) and a target signal (Star).
G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
45.
METHODS OF OBTAINING KERATIN PROTEIN ISOLATE, KERATIN AMYLOID FIBRILS AND FABRICATING MEMBRANES USING THE SAME
The present invention relates to a method of obtaining keratin protein isolate from a keratin source, the method comprising: (a) preparing a first mixture comprising keratin source, chaotropic solvent, and a first reducing agent; (b) precipitating keratin protein from the first mixture; (c) preparing a second mixture comprising the keratin protein and a second reducing agent; and (d) precipitating keratin protein isolate from the second mixture. The present invention also relates to a method of obtaining keratin amyloid fibrils, the method comprising: (i) obtaining keratin protein isolate; (ii) preparing a third mixture comprising keratin protein isolate, acid solution, and a third reducing agent; and (iii) subjecting the third mixture to heat treatment to obtain keratin amyloid fibrils. The present invention also relates to a method of fabricating a membrane for an electrochemical cell or a proton conductive cell.
The present invention is directed to a method for introducing charged compounds into three-dimensional biological tissues comprising the step of introducing at least one charged compound of interest into the biological tissue, wherein a composition for dissolving and removing lipids and/or a composition for introducing at least one charged compound of interest into the bio- logical tissue is injected into the biological tissue and a pulsed electrical field (PEF) is applied to the biological tissue. The invention further relates to a device for use in this method, and a use of this method or this device for histological staining.
San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (USA)
J. CRAIG VENTER INSTITUTE (USA)
ETH ZURICH (Switzerland)
Inventor
Shikuma, Nicholas J.
Beyhan, Sinem
Pilhofer, Martin
Ericson, Charles
Abstract
Provided are compositions, kits, and methods for delivering a proteinaceous cargo, or a protein or a peptide, or a drug or a marker, to or into a cell or to an individual in need thereof. Methods comprise use of: a substantially purified or isolated bacterial Contractile Injection Systems (CIS) or Metamorphosis Associated Contractile structure; a recombinant bacterial Contractile Injection Systems (CIS) or Metamorphosis Associated Contractile structure (MACs); a liposome or lipid-comprising nanoparticle incorporating or expressing on its outer surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs; a protoplast or a spheroplast incorporating or expressing on its outer surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs; a cell expressing on its extracellular surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs.
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
49.
METHOD FOR PRODUCING A NANO-STRUCTURED ELEMENT MADE OF HEXAGONAL BORON NITRIDE AND DEVICE COMPRISING SUCH AN ELEMENT
A method is indicated for producing a nano-structured element (1) made of hexagonal boron nitride (hBN). The method comprises the steps of a.) generating a relief structure (4) in the surface (31) of a resist (3), the resist in particular being a polymer resist (3); of b.) placing the resist (3) on the hBN-element (1); and of c.) transferring the relief structure (4) from the resist (3) into the hBN-element (1) by means of etching. Furthermore, a device is indicated comprising one or several nano-structured hBN-elements (1), the one or several hBN-elements (1) having a relief structure (4) provided for the targeted influencing of the electronic, optical and/or mechanical properties of the device.
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
An acoustofluidic device and a method for trapping particles with a positive acoustic contrast contained in a moving carrier fluid are disclosed. The device has a first channel channeling the moving carrier fluid and a second channel. The first channel and a portion of the second channel parallel to the first channel are separated by a common separating wall. A driving circuitry driving an acoustic transducer is configured to drive the latter at a frequency at which an acoustic radiation force is generated on the particles in the first channel that points towards a displacement antinode of a vibrational eigenmode of the separating wall, while at least two counter-rotating streaming vortices are formed by the moving carrier fluid which, in combination with the acoustic radiation force, form a particle trap at said displacement antinode of the eigenmode.
Techniques for generating robotics control signals are disclosed. Movement data is received for a desired motion for a robotics device, which can include animation, motion capture, sensor data, or movement of a different robotics device. Robotics device data is received, including control data and reference points corresponding to locations on the robotics device. A correlation is determined between movement data points in the movement data and the reference points. Using the control data, a control signal is determined based on the desired motion. The control signal is based on a distance between at least one movement data point and at least one reference point. The disclosed technology can retarget motions onto under-actuated systems and without regard to differences in degrees of freedom, mass distributions, and proportions of robotics devices.
According to the present invention there is provided a method for providing a conductive polymer material (9) on a fabric (1), the method comprising the steps of, (a) providing a fabric (1); (b) impregnate the fabric (1) with oxidant (2); (c) exposing the fabric (1) to a monomer vapor (7) so that the monomer vapor (7) reacts with the oxidant (2) impregnated in the fabric (1) to generate a conductive polymer material (9) on the fabric (1). There is further provided a fabric comprising a conductive polymer material formed using the method of the present invention.
D06M 11/28 - Halides of elements of Groups 8, 9, 10 or 18 of the Periodic Table
D06M 11/48 - Oxides or hydroxides of chromium, molybdenum or tungstenChromatesDichromatesMolybdatesTungstates
D06M 11/50 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with hydrogen peroxide or peroxides of metalsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with persulfuric, permanganic, pernitric, percarbonic acids or their salts
D06M 11/83 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metalsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metal-generating compounds, e.g. metal carbonylsReduction of metal compounds on textiles
D06M 23/06 - Processes in which the treating agent is dispersed in a gas, e.g. aerosols
D06M 23/12 - Processes in which the treating agent is incorporated in microcapsules
D06M 23/16 - Processes for the non-uniform application of treating agents, e.g. one-sided treatmentDifferential treatment
D06M 15/03 - Polysaccharides or derivatives thereof
D06M 15/356 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of other unsaturated compounds containing nitrogen, sulfur, silicon or phosphorus atoms
D06M 23/14 - Processes for the fixation or treatment of textile materials in three-dimensional forms
The present invention relates to novel methods to manufacture composite materials comprising amyloid fibrils and a biodegradable polymer. The methods described herein prove to be environmentally friendly and allow the use of starting materials of low quality/purity. Specifically, amyloid fibrils may be obtained from food waste. The invention further provides for novel composite materials comprising specific amyloid fibrils and a biodegradable polymer, to articles comprising such composite materials and to the use of such composite materials. The composite materials described herein show unexpected beneficial properties, when compared to the individual constituents. These beneficial properties include improved mechanical properties, improved biodegradation, improved antioxidant properties, and beneficial optical properties.
An automated design method, and corresponding computer system for implementing such a method and robot mechanism with an optimized flexible link, that is configured to optimize a desired load-displacement behavior of planar flexible-link mechanisms at expected points of interaction. To implement the new design method, a subset of rigid links of an existing rigid-link robot mechanism are replaced with flexible links, optimizing their rest configurations. The efficacy of the design approach has been proven with two fabricated prototypes of robot mechanisms, with one being adapted for grasping tasks and one being adapted for locomotion tasks.
A method of producing an alloy including magnesium and calcium, preferably an implantable medical device having magnesium and calcium, includes the steps of generating a billet including magnesium and calcium, and extruding the billet. The billet is extruded at least once at an extrusion temperature in the range of 250° C. to 450° C. and at a ram speed in the range of 0.01 mm/s to 1 mm/s and at an extrusion ratio in the range of 20 to 150 and preferably at an extrusion ratio in the range of 35 to 150.
C22F 1/06 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
Suspensions containing oxidic nanoparticles as a dispersed phase and an aqueous solution containing citric acid as a diluent are disclosed. Advantageously, the oxidic nanoparticles contain bioglass and ceria. Also further disclosed are topical dosage forms including such oxidic nanoparticles and uses thereof. The dosage forms were found to be useful in the treatment of wounds and post-operative lesions, and particularly for the prevention of seroma, the prevention of infections and/or the prevention of inflammation.
In a method of investigating cell deformations, a sample fluid including cells suspended in a suspending medium is provided. A flow of the sample fluid through a focusing microchannel is established. The suspending medium is a non-Newtonian fluid having viscoelastic properties such that cells that enter the focusing microchannel are focused towards a center of the focusing microchannel due to the viscoelastic properties of the suspending medium, causing the cells to exit the focusing microchannel in single file. Subsequently, the sample fluid that has exited the focusing microchannel is caused to flow through a deformation microchannel arranged downstream of the focusing microchannel to cause a deformation of cells that have exited the focusing microchannel and have entered the deformation microchannel, the deformation being caused by a flow pattern created by interaction of the fluid flow with the deformation microchannel.
The invention relates to the fields of biomolecular computing and/or synthetic biology. In particular, the invention relates to a DNA construct that comprises a first promoter, at least one further promoter and an output sequence, wherein each of said promoters comprises a transcription start site and/or is suitable for initiating transcription, wherein the initiation of transcription from the first promoter is enabled by a first transcriptional regulatory state and the initiation of transcription from each of said further promoter(s) is enabled by a respective further transcriptional regulatory state, and wherein said DNA construct yields an effective amount of an output RNA in a eukaryotic cell, when said first transcriptional regulatory state and/or any of the respective further transcriptional regulatory states is present in said cell, wherein said output RNA comprises a sequence corresponding to said output sequence. Furthermore, the invention relates to medical and/or diagnostic uses of the inventive DNA construct of the invention, e.g., for detecting, killing and/or manipulating different types of eukaryotic target cells in a subject and/or in a tissue sample.
A method for producing a nano- or micro-sheet element is provided, the nano- or micro-sheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising a growth substrate (1), a nano- or micro-sheet layer (2) and a support layer (3). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2) and the support layer (3). The step of electrochemical delamination of the laminate (14) is carried out with the support layer (3) having a pattern (31) with a plurality of local depressions (311) and/or elevations (312).
The present invention is generally in the fields of synthetic biology, gene therapy, and cell therapy. The invention relates, inter alia, to a synthetic transcription factor comprising a DNA binding domain derived from a mitochondrial DNA binding protein (e.g. MTERF1) and a transcriptional modulation domain derived from one or more other proteins; a nucleic acid or combination of nucleic acids encoding the inventive synthetic transcription factor; a DNA construct comprising a MTERF1 binding site and a minimal promoter; a system comprising the inventive synthetic transcription factor and the inventive DNA construct; and uses thereof, e.g. medical uses.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
A substrate (1) for preventing a fluid (2) from misting, in particular from fogging, an article (3) comprises at least one surface (4) comprising a surface structure (5). The surface structure (5) is formed by a plurality of protrusions (6) and a plurality of indentations (7) extending along an extension direction (E). The surface structure (5) is configured to generate capillary forces on a fluid (2) such, that the fluid (2) forms a fluid layer (8) among the surface structure (5).
A method for producing a nano- or micro-sheet element is provided, the nano- or microsheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising at least a growth substrate (1) and a nano-or micro-sheet layer (2). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2). In the electrochemical delamination of the laminate (14), a gas diffusion electrode (21) attached to the nano- or micro-sheet layer (2) is used as an anode and an electrolyte membrane, in particular a polymer electrolyte membrane (20), is arranged between the gas diffusion electrode (21) and the nano- or micro-sheet layer (2).
The invention relates to a method, system and computer program for determining a tracer flow in a measurement space, the method comprising the steps of: • a) Injecting tracers at a first injection region into the measurement space with a tracer seeding device configured to inject tracers at an adjustable injection region in the measurement space, • b) Recording the measurement space with two or more event-cameras, wherein each event-camera comprises a plurality of sensors configured to generate output data each time a sensor of the event camera senses a change in light intensity, wherein the output data comprises an information on a position of the sensor that sensed the change in light intensity, and a time of the change in light intensity, • c) From the data of the event-cameras, determining with a processor for at least some of the injected tracers a trajectory in the measurement space, wherein each trajectory comprises at least an information on a time-resolved three-dimensional position of the tracer, wherein the determination of the trajectories is facilitated in real time, • d) While executing steps b) and c), adjusting the injection region to at least a second injection region different from the first injection region.
G01P 5/20 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the time taken by the fluid to traverse a fixed distance using particles entrained by a fluid stream
G01M 9/06 - Measuring arrangements specially adapted for aerodynamic testing
64.
ASPIRATION DEVICE FOR DETERMINING MECHANICAL PROPERTIES OF SOFT TISSUES AND METHODS THEREFOR
An aspiration device (110) for measuring the viscoelastic deformability of biological tissues and synthetic materials comprises a probe head (11), a probe channel (41), a pressure unit (20), a pressure sensor (31) and a control unit (60). The first probe channel (41) is connecting the pressure unit (20) providing a vacuum with the probe head and includes the pressure sensor (31) detecting the pressure in the first probe channel (41). The first probe channel (41) has a distal end (141) leading with its lower open end (144) through the top wall (14) into the cavity (15) of the probe head. The cavity (15) comprises either an opening (16) in the side or top wall (13, 14) or a second probe channel connected with a valve. A measurement cycle comprises applying under pressure in the first probe channel (41), measuring the under pressure with the pressure sensor (31), detecting a change of under pressure increase over time (301, 401), increasing the under pressure to a predetermined maximum under pressure (303), decreasing the under pressure beyond this point in time and detecting a change of under pressure decrease over time (302, 402).
The present invention relates to a method for predicting the likelihood of developing, or of diagnosing, a systemic post-infection syndrome via measuring the amount of C7 in a patient sample, particularly the amount of liquid-phase (soluble) or complexed C7. The invention particularly relates to the diagnosis of long COVID. The invention further relates to a treatment or prevention of a systemic post-infection syndrome via administering to a patient an agent able to mimic or modulate the biological activity of C7.
The present invention relates to a method for identifying a modified amino acid degron (MAAD) and factors mediating the selective degradation of a protein tagged with the MAAD.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
C40B 30/08 - Methods of screening libraries by measuring catalytic activity
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A sensor system for a three-dimensional device, in particular for arrangement on a surface of and/or in a surface of a three-dimensional device, having at least one central device, at least one supporting device, and at least one sensor device. The supporting device is in connection with the central device. The sensor device is in communication with the central device. The central device is configured to receive at least one sensor signal from the sensor device. The supporting device is of an elongated shape and extends at least partially along an elongation direction. The sensor device is at least partially integrated into the supporting device.
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
68.
ANALYTICAL COMPOSITION FOR MONITORING DISINFECTION
The present invention relates to analytical compositions and kits, their use for monitoring disinfection procedures, and a method for monitoring a disinfection procedure. The analytical composition comprises lipid nanoparticles encapsulating a nucleic acid.
An electronic device (1) comprises a time-modulated receiver array (RX) or a beamforming network (BFN) connected with a time-modulated transmitter array (TX), wherein the time-modulated transmitter array (TX) includes a plurality of switches (ST1, …, STN) which are periodically operable between an on state (1) and an 5 off state (0) for periodic signal transmission to a plurality of antenna elements (AT1, …, ATN).
G01S 7/03 - Details of HF subsystems specially adapted therefor, e.g. common to transmitter and receiver
G01S 13/42 - Simultaneous measurement of distance and other coordinates
G01S 13/931 - Radar or analogous systems, specially adapted for specific applications for anti-collision purposes of land vehicles
H01Q 3/24 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the orientation by switching energy from one active radiating element to another, e.g. for beam switching
H01Q 3/26 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture
H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
70.
COMPOUND FOR USE AS A PEPTIDE BINDER SPECIFICALLY BINDING TO THE UBIQUITIN LIGASE ADAPTER FBXO31
2n11010 alkyl residue, or forms together with a residue of V a ring system, wherein U is a sequence of three amino acids and the C-terminal amino acid of U is selected from the group consisting of I, L, V, F, N, Y, S, T, A, W and M.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A heating device (1) for preventing or removing a deposition comprises or consists of at least one photothermal element (2) being configured to exhibit a photothermal effect upon an impingement of electromagnetic radiation. The photothermal element (2) comprises or consists of particles (3) being embedded in a matrix (4). The matrix (4) is optically transmissive in a first wavelength region of the electromagnetic spectrum of impinging electromagnetic radiation. The particles (3) are configured to absorb impinging electromagnetic radiation in a second wavelength region of the electromagnetic spectrum and are further configured to dissipate the absorbed electromagnetic radiation as heat, whereby the temperature of the heating device (1) is elevated.
C08J 7/00 - Chemical treatment or coating of shaped articles made of macromolecular substances
72.
INTEGRATED DRAM CIRCUIT, METHOD FOR OPERATING THE INTEGRATED DRAM CIRCUIT BY REFRESHING MEMORY CELLS OF THE INTEGRATED DRAM CIRCUIT, AND METHOD FOR PREVENTING A DATA INTEGRITY ATTACK
L1L2L1L2LN1112NM1112L1BL2LNL1L2LNL1L2asa1apBL1L2asa1asasL1L2a1apas1112NMNM) of the integrated DRAM circuit. Finally the invention relates to a method for preventing a data integrity attack in the integrated DRAM circuit with the use of said method for operating the integrated DRAM circuit.
G11C 7/12 - Bit line control circuits, e.g. drivers, boosters, pull-up circuits, pull-down circuits, precharging circuits, equalising circuits, for bit lines
G11C 11/406 - Management or control of the refreshing or charge-regeneration cycles
G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating
G11C 11/4094 - Bit-line management or control circuits
73.
Electrical converter and method for operating an electrical converter
A DC-DC converter topology based on electromagnetically coupled class-D LC oscillator is proposed. An electrical converter comprises at least two oscillators (1,2), each of the at least two oscillators being designed to have an oscillating current and an oscillating voltage. Coupling elements (16, 17, 18, 19) arranged to couple the oscillating currents of the at least two oscillators and/or the oscillating voltages of the at least two oscillator. The at least two oscillators are connected in a series connection, adding their oscillating voltages, and/or in a parallel connection, adding their oscillating currents. The topology can be fully integrated, that is, it can be realized as an integrated circuit without external components, in particular without external passive components, such as capacitors and/or inductors.
H03F 3/217 - Class D power amplifiersSwitching amplifiers
H02M 3/338 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only in a self-oscillating arrangement
74.
NOVEL SENSORS SUITABLE FOR MONITORING MOVEMENT AND OTHER BIOPHYSICAL PARAMETERS
The invention relates to the field of mobile health technology and activity monitoring and refers in particular to sensors suitable to be used for wearable electronic devices. The first aspect of the invention refers to flexible or stretchable sensors that can be seamlessly incorporated into textiles, clothing, and wearable devices. A second aspect of the invention refers to a sensor using helical-auxetic yarns for construction of a capacitor. The sensors can also be stretchable and are suitable for use in textiles and for sensing body motion (strain).
G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
D03D 1/00 - Woven fabrics designed to make specified articles
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
G01L 1/22 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges
G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
G01P 15/125 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values by capacitive pick-up
G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
75.
AIR-DRIED CELL MONOLAYERS AND METHODS OF PREPARING THE SAME
The invention relates to methods for the creation of a cell monolayer comprising: a) providing a cell population; b) culturing said cell population in a liquid medium; and c) air-drying the cell population with a sample evaporator to create a cell monolayer; and optionally d) staining the air-dried sample with histological or other stains. The invention is particularly advantageous for use in high-throughput, high-content analysis of cell samples and, in particular, examining the effect of therapeutic agents on said cell samples.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
76.
METHOD OF TRAPPING AND RECONFIGURING CHARGED PARTICLES FOR PERFORMING QUANTUM OPERATIONS AND ELECTRIC FIELD SENSING
A method of trapping and reconfiguring at least one charged particle (1) in a trapping apparatus (2) comprising at least one trapping unit cell (3) and at least one magnet configured to generate a magnetic field (B) is provided. The trapping unit cell (3) comprises at least one trapping control layer (4) comprising a trapping surface (5) and at least two electrodes (6, 6a). The method comprises the steps of trapping at least one charged particle (1) on a trapping site (7) being generated above the trapping surface (5), cooling the motional modes of the at least one charged particle (1) by coupling its magnetron motional mode to at least one of the other motional modes while simultaneously irradiating electromagnetic radiation onto the charged particle, and reconfiguring a spatial position of the trapping site (7) by applying a time-varying voltage to the electrodes (6, 6a), whereby the at least one charged particle (1) is moved along at least one spatial direction (x, y, z).
The present invention pertains to liquid droplets including a polymer according to Formula (I) and to their use in an aqueous medium for the uptake of compounds from outside the droplets into the droplets for separation, storage and/or reaction of compounds inside the droplets, as well as associated methods of production of the polymer.
The present invention relates to wearable device (1) adapted to detect contacts of fingers (F) on a surface (S), and to identify the responsible finger. It comprises move sensors adapted to collect the vibrations resulting from the contact of the fingers on a surface. It comprises a memory comprising reference vibration profiles (T), corresponding to the impact of at least one finger (F) of a user (U) to a surface (S). A computing unit (32) is configured allows to identify the finger responsible for the impact sensed by the move sensors (10, 10a, 10b). The invention further relates to a manufacturing process of such a device and to a method of sensing the contact of a finger on a surface.
Provided herein, in some embodiments, are engineered nucleic acid targeting vectors that include a sequence of interest flanked by homology arms, each homology arm comprising a sequence homologous to a sequence in a safe harbor site in the human genome in any one of the following loci: 1q31, 3p24, 7q35, and Xq21. Also provided herein are methods of using and compositions the comprising engineered nucleic acid targeting vectors.
The present invention relates to a bispecific antibody comprising at least a first binding domain and a second binding domain, wherein said first binding domain binds to an organic fluorophore and wherein said second binding domain binds to CD3, and to a combination thereof with a labelled binding agent that binds specifically to a target antigen, wherein the labelled binding agent is labelled with an organic fluorophore.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
System for producing somatotopic sensations using Transcutaneous Electrical Nerve Stimulation (TENS) in the lower limbs is provided, the system comprising a wearable device to be attached to a lower limb of an individual, the wearable device comprising at least two units, each comprising one or more arrays of TENS electrodes to be associated with at least one nerve of the lower limb, and wherein the system is configured to select electrodes of at least one array of electrodes, and stimulation signal parameters to be applied thereto, and control the stimulation of at least one nerve associated with the array of electrodes comprising the selected electrodes.
The present invention relates to a catalyst for the electrocatalytic reduction of nitrate, nitrite, and NO comprising an electrically conductive support having a hierarchical structure, wherein at least a part of the outer surface of the electrically conductive support is covered by a catalytically active molybdenum layer, wherein said molybdenum layer comprises both metallic molybdenum and oxidized molybdenum and containing less than 10% of other metals and metal oxides.
C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection
C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
An arrangement for additive manufacturing of a structure, preferably an architectural structure, the arrangement comprising a nozzle having a construction material outlet configured to extrude construction material in the form of a hollow core bead along a manufacturing path defined by multiple points, a fluid outlet configured to inject a fluid into the hollow core of the extruded bead, a fluid pressure adjusting device configured to adjust a pressure of the fluid injected into the hollow core of the extruded bead via the fluid outlet, and a control unit configured to determine a pressure value assigned to a point of the manufacturing path and to control the fluid pressure adjusting device on the basis of the determined pressure value. Furthermore, a method for generating control data for such an arrangement is disclosed.
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
A method for laterally confining neutral excitons in a semiconductor layer structure (11) of a solid-state device comprises creating an inhomogeneous electric field (F) in the semiconductor layer structure (11), the electric field (F) having an in-plane field component (Fx) whose magnitude varies along at least at least one confinement direction (x) in the device plane, the magnitude of the in-plane field component (Fx) having a maximum along the confinement direction (x). In this manner a lateral confining potential (V(x)) for neutral excitons is caused around the maximum. The solid-state device (10) is irradiated with light to create neutral excitons in the semiconductor layer structure (11). The neutral excitons are laterally confined along the confinement direction (x) by the lateral confining potential (V(x)).
H01L 31/112 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor
The present invention relates to compositions for use in the treatment, amelioration, and or prevention of myotonic dystrophy (DM) including DM1 and DM2. The compounds can disrupt the activity of Lin28 (e.g., Lin28A and/or Lin28B), RNA binding proteins responsible for inhibiting the maturation of miRNA precursors to mature miRNA. Upon treatment with the inventive compounds, the DM1 and DM2 cells exhibited (i) increased MEF2A expression (i.e., de-repression of MEF2A associated with DM); (ii) decreased CELF protein expression (e.g., decreased CELF1 expression); (iii) increased expression of miRNAs associated with DM and shifted the targetomes of the miRNAs toward a healthy signature; (iv) decreased expression of sodium-, potassium- and calcium ion channels with roles in myotonia, muscle wasting, and cardiac conduction; (v) increased expression of CLCN1; and (vi) decreased expression of PKC.
The invention relates to a steerable device (10) comprising an elongated element (12) configured to be navigated through the mammalian body. The elongated element (12) has a device tip (20) configured for allowing steering of the elongated element (12) by way of an external magnetic field. Further, the device tip (20) comprises a plurality of segments (26), each segment (26) including a segment body (36) and a segment interface (38a, 38b), and a plurality of connectors (24), each connector (24) including a connector body (40) and a connector interface (42a, 42b). The connector interfaces (42a, 42b) and the segment interfaces (38a, 38b) have each time mutually complementing shapes allowing rotational movements relative to each other and forming a connection to retain the connectors and the segments in a mated condition, and the magnetic elements (34) form at least partially segment bodies or connector bodies or both.
Slurry for the coating of a cathode of lithium ion battery, wherein the slurry consists of a solid fraction and of a solvent/dispersant fraction, wherein the solid fraction consists of: (a) 90-95% by weight of a lithium metal oxide based particulate electrochemically activatable material; (b) 2-6% by weight of an acidic polyacrylate or polymethacrylate binder material; (c) 2-6% by weight of conductive particulate carbon; (d) 0-2% by weight further additives different from (a)-(c) wherein the sum of (a)-(d) make up 100% of the solid fraction and wherein the solvent/dispersant fraction consists of: (A) 5-25% by weight of an organic alcoholic solvent/dispersant; (B) 5-30% by weight of water (C) 0-5% by weight of solvents/dispersants different from (A) and (B) wherein the percentages of the solvent/dispersant fraction are relative to the 100% solids fraction.
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
The present invention comprises a fish guidance rack (2) for use in a fish guidance system in a watercourse (W) at a run-of-river hydropower plant or a water intake. The rack comprises a series of vertical bars (1) mounted on a rack frame (7) along a longitudinal axis (L) of the rack between a first end (5) of the rack and a second end (6) of the rack. The rack comprises bars with a hydrodynamic curved form, and a generally increasing inter-bar spacing (sb) in the downstream direction.
An implantable sensor (1) for determining at least one parameter, in particular a physical parameter, comprises a sensor body (3). The sensor body (3) is responsive to the at least one parameter and is configured to yield at least one response signal (SR) upon an interrogation of the sensor body (3) with at least one interrogation signal (SI) comprising acoustic waves. The at least one response signal (SR) is associated with the at least one parameter. The sensor body (3) comprises or consists of at least one material having an ordered structure (4). The at least one response signal (SR) is associated with one or more bulk effects of the at least one material having an ordered structure (4).
A solar receiver (1, 1a, 1b) comprises an enclosure (2) delimiting a cavity (3) that is configured to receive a heat transfer fluid (4), at least one opening (5) in the enclosure (2) for access of solar radiation (R) into the cavity (3), at least one window (7) that seals the opening (5), and at least one cooling device (8, 8a, 8b) that is configured to cool the window (7). The cooling device (8, 8a, 8b) is configured to supply at least one window-cooling liquid fluid (9) to the window (7), such that the window-cooling liquid fluid (9) forms at least one liquid layer (10) on and/or in the window (7).
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relates to a process for the stereoselective preparation of such compounds. The compound of formula (I) can be used as a medicament, in particular for inhibiting coronin 1 expression in the induction of immunosuppression or in the treatment and/or prevention of a disease or disorder selected from the group consisting of transplant rejection, autoimmune diseases, inflammatory diseases, infectious diseases, and lymphoproliferative disorders. The present invention further relates to a vector comprising a coronin 1 promoter element, wherein in a vertebrate genome, said coronin 1 promoter element starts directly upstream from a transcription starting site (TSS) of a coronin 1 gene and spans a sequence stretch of at least about 700 bp in said genome. The present invention further relates to a method using said vector for identifying immunomodulatory compounds that alter the coronin 1 promoter activity. The present invention further relates to BRD3 as an upstream target responsible for driving the coronin-1 expression and activity in immune cells, and relates to compounds, in particular compound of formula (I), that selectively target bromodomains of BRD3 and thereby deplete coronin 1 levels.
C07D 215/54 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A fabrication method of an elastomer breath structure includes the steps of applying a liquid elastomer onto a substrate an initial curing of the liquid elastomer on the substrate partially into a partially cured polymer, condensation of water droplets from the environment onto the partially cured polymer, and finishing curing of the partially cured polymer with parallel removal of the water droplets creating surface dimples on the cured elastomer.
Disclosed herein is an artificial transmembrane protein for use in a biomolecular detection device for detecting intracellular or intravesicular biomolecular interactions, the artificial transmembrane protein having an extracellular or extravesicular binder structure, a hydrophobic transmembrane domain, and an intracellular or intravesicular domain with an intracellular or intravesicular receptor structure, wherein the receptor structure is configured to interact with an intracellular or intravesicular component of the biomolecular interaction to be detected and wherein the extracellular or extravesicular binder structure is configured to bind to membrane recognition elements arranged along a plurality of predetermined lines of the biomolecular detection device.
The present invention relates to a lipid emulsion for total parenteral and enteral (oral or through gastric or duodenal tubes) nutrition. The lipid emulsion has advantageous immuno-modulating, anti-inflammatory, and anti-diabetic effects. The lipid emulsion may also comprise a pharmaceutical drug, can be used as a detoxifier, or for reversing negative effects from ischemia-reperfusion injury.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
96.
COMPOSITIONS FOR PARENTERAL SUSTAINED RELEASE DELIVERY OF HYDROPHILIC DRUGS
A first aspect of the invention relates to a pharmaceutical composition comprised of spherulitic vesicles of a lipid phase in an aqueous phase comprising an inositol derivative as a pharmaceutical drug. The aqueous phase is comprised in vesicles constituted by a plurality of concentric lipid layers of a lipid phase, separated by continuous layers of the aqueous phase. The lipid phase comprises a cone-shaped first component consisting of a surfactant characterized by a CPP value of <1 and an inverse-cone-shaped second component consisting of a surfactant characterized by a CPP value of >1. Other aspects of the invention relate to a lipid precursor composition suitable for preparing the pharmaceutical composition, and to a biphasic precursor composition from which the pharmaceutical composition as disclosed as the first aspect of the invention may be prepared by application of shear stress.
The invention relates to a method for facilitating forgery detection of a received paper document (12) using a mobile device (13). The method comprises the following steps: a) receiving (1) an original reference image (10), b) receiving (2) an image (15) of the received paper document (12) captured using a camera in the mobile device (13), c) receiving (3) a first threshold 5 and a second threshold T, d) determining (4) a homography between the captured image (15) and the original reference image (10), e) aligning (4) the captured image (15) to the original reference image (10) based on the determined homography, the aligning providing an aligned captured image (17), f) determining (5) a difference map (16) based on the aligned captured image and the original reference image, g) determining (5) a first difference region in the difference map using the first threshold 5 and the second threshold T, and determining (5) a first region in the aligned captured image and a first region in the original reference image corresponding to the determined first difference region, h) determining (6) a further region in the aligned captured image based on the first region in the aligned captured image, and determining (6) a further region in the original reference image based on the first region in the original reference image, i) determining (7) a further homography between the further region in the aligned captured image and the further region in the original reference image, j) aligning (7) the further region in the aligned captured image to the further region in the original reference image based on the determined further homography, the aligning providing an aligned further region of the aligned captured image, k) determining (8) a further difference map based on the aligned further region and the further region in the original reference image, I) determining (8) a second difference region in the further difference map using the first threshold 5 and the second threshold T, and determining (8) a second region in the aligned further region and a second region in the original reference image corresponding to the determined second difference region, and m) providing an output region, based on the second region, in the aligned further region and an output region, based on the second region, in the original reference image as output (9). The invention also relates to a computer programme product and to a mobile device configured to carry out the computer programme product.
A ring waveguide quantum cascade laser (1) based on whispering gallery modes. The ring waveguide (2) is bounded vertically upwards and downwards by refractive index differences between horizontally extending semiconductor layers of a semiconductor stack (10-18) including active region layers (14). The ring waveguide (2) is bounded radially outwards by an outside sidewall (31) that is covered with a dielectric-metal mirror (22, 24) to reflect the whispering gallery modes back into the ring waveguide and thereby reduce scattering losses. The ring waveguide is bounded radially inwards by an inside sidewall (33) that is a buried interface that interfaces with a horizontally extending central layer (369 of insulating semiconductor material to confine the carrier injection to taking place vertically across the active region layers (14).
H01S 5/10 - Construction or shape of the optical resonator
H01S 5/187 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only horizontal cavities, e.g. horizontal cavity surface-emitting lasers [HCSEL] using Bragg reflection
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
99.
METHOD AND DEVICE FOR ASSESSING CORROSION PHENOMENA
The invention relates to a method for assessing corrosion phenomena on at least one metal element (1) of a concrete structure (2) covered at least in regions with a material (3) that is electrolytically conductive or can be made electrolytically conductive, in which an electrolyte volume (4) is positioned within the material (3), an electrode (5) is arranged in the electrolyte volume (4) so that the electrode (5) and the electrolyte are in electrically conductive connection, and the electrolyte volume (4) is brought into electrically conductive contact with the material (3), and an electrochemical measurement indicative of a state of corrosion on the metal element (1) is carried out. The invention also relates to a device (11) for assessing corrosion phenomena on at least one steel element (1) of a concrete structure (2) covered at least in regions with a material (3) that is electrolytically conductive or can be made electrolytically conductive.
The present invention relates to bone cement composites comprising at least one cement base material and biodegradable metallic fibers made of a metal alloy, said fibers comprising at least three chemical elements in the alloy, wherein at least one of these elements is selected from the group consisting of magnesium and calcium. The fibers are amorphous in a volume fraction of more than 75%, with the remaining part of the fibers being of crystalline atomic structure.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
A61L 27/58 - Materials at least partially resorbable by the body
