Abstract

Systems and methods are provided to provide a prediction for a physiological parameter of a patient to a clinical decision support tool. For that purpose, a real-time or near real-time data stream is accessed of measured values of a physiological parameter of a patient. A trained machine learning model is used to generate, using a time-series of measured values from the real-time or near real-time stream as input, a time-series of predicted values as output. It is determined whether predicted values fall within a physiological range associated with the physiological parameter, thereby obtaining a time-series of classifications, wherein a respective classification is indicative of whether a predicted value falls inside or outside of the physiological range. The time-series of classifications provided to the clinical decision support tool, for example to visualize the time-series of classifications in a graphical representation of a patient's medical condition.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A binder composition, especially a mortar or concrete composition, comprises: a) a binder comprising calcium sulfate (C$) and at least one of calcium aluminate cement (CAC) and/or a calcium sulfoaluminate cement (CSA); b) a polycarboxylate ether-based superplasticizer comprising a polycarboxylate backbone and polyether side chains, and whereby the polyether side chains have a number average molecular weight Mn of at most 4'000 g/mol; c) at least a first surfactant and a second surfactant, whereby the first and the second surfactant are chemically and/or physically different from each other and from the polycarboxylate ether-based superplasticizer.

IPC Classes  ?

• C04B 28/06 - Aluminous cements
• C04B 28/16 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing calcium sulfate cements containing anhydrite
• C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability

Abstract

The present invention relates to an oleogel composed of protein nanofibrils and ≥95% oil, without the need for an emulsifier. The present invention also relates to a method for the production of this oleogel.

IPC Classes  ?

• A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
• A23D 7/02 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
• A23D 9/007 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
• A23D 9/02 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by the production or working-up

Abstract

One aspect of the invention relates to a method for making a three-dimensional hydrogel bioimplant, characterized by geometrical structures in sub-millimeter size range. The method comprises the provision of a first composition susceptible to photo-crosslinking in a container. This first composition comprises a first polymer susceptible to photo-crosslinking, a photoinitiator and optionally, a refractive index matching agent, a photo absorptive dye, and a crosslinking agent. In a first illumination step, the composition is illuminated with a plurality of spatially coherent light beams, whereby a plurality of micropillars is generated in the composition. Another aspect of the invention relates to a three-dimensional hydrogel implant comprising or essentially consisting of a plurality of microbeams of a photo-crosslinked polymer, said three-dimensional hydrogel implant obtained by a method according to the invention.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Abstract

A steerable device for use inside of a mammalian body, including: a flexible elongated element and a magnetic element placed in a distal end portion of the elongated element to allow steering by way of an external magnetic field. The steerable device includes a structured section arranged proximal to the magnetic element and having a plurality of elongated protrusions formed on an outer surface of the elongated element. The elongated protrusions have each a protrusion longitudinal axis, each protrusion longitudinal axis forming an angle with a device longitudinal axis, wherein each angle is less than 90°, such that rotation of the elongated element in the clockwise direction around the device longitudinal axis effects a movement of advancement of the elongated element relative to the soft tissue. In a further aspect, the structured section is in the form of an outer thread structure.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61B 1/005 - Flexible endoscopes
• A61B 1/01 - Guiding arrangements therefor
• A61M 25/00 - CathetersHollow probes

Abstract

The invention relates to an electronic driver circuit (EDC) for driving a resonator element (XO) for providing an electronic oscillator (1). The electronic driver circuit (EDC) comprises: a synthesizer section (SYN) which is configured to receive a reference signal (XO_SIG.N, XO_SIG.P) from the resonator element (XO) and to generate a synthesizer signal (SYN_SIG) having a synthesizer frequency (SYN_F) which is equal to, lower or higher than a reference frequency (XO_F) of the reference signal (XO_SIG.N, XO_SIG.P), and having a phase resolution below or equal to 90 degrees with respect to the reference signal (XO_SIG.N, XO_SIG.P); and a pulse injection section (PJD.N, PJD.P) which is configured to inject an injection signal (INJ.N, INJ.P) into the resonator element (XO) at an injection time (T.N, T.P) which is selected using the synthesizer signal (SYN_SIG), or using the synthesizer signal (SYN_SIG) and the reference signal (XO_SIG.N, XO_SIG.P). The electronic driver circuit (EDC) enables providing an electronic oscillator (1) having improved power and noise efficiency.

IPC Classes  ?

• H03B 5/06 - Modifications of generator to ensure starting of oscillations
• H03B 5/36 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element being electromechanical resonator being a piezoelectric resonator active element in amplifier being semiconductor device

Abstract

An electronic nose (1) comprises an array of sensing pixels (MOF1, MOF2, T), and electronic circuits connected to the sensing pixels (MOF1, MOF2, T) for reading the sensing pixels (MOF1, MOF2, T).

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The present invention relates to compositions for use in the treatment, amelioration, and or prevention of myotonic dystrophy (DM) including DM1 and DM2. The compounds can disrupt the activity of Lin28 (e.g., Lin28A and/or Lin28B), RNA binding proteins responsible for inhibiting the maturation of miRNA precursors to mature miRNA. Upon treatment with the inventive compounds, the DM1 and DM2 cells exhibited (i) increased MEF2A expression (i.e., de-repression of MEF2A associated with DM); (ii) decreased CELF protein expression (e.g., decreased CELF1 expression); (iii) increased expression of miRNAs associated with DM and shifted the targetomes of the miRNAs toward a healthy signature; (iv) decreased expression of sodium-, potassium- and calcium ion channels with roles in myotonia, muscle wasting, and cardiac conduction; (v) increased expression of CLCN1; and (vi) decreased expression of PKC.

IPC Classes  ?

• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

2ww of less than 1000 g/mol measured by GPC.

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
• C07C 4/22 - Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms by depolymerisation to the original monomer, e.g. dicyclopentadiene to cyclopentadiene

Abstract

The present invention relates to anchoring element for a joint implant, a joint implant and a method of fabrication thereof. Specifically, the anchoring element for a joint implant according to the present invention comprises a bone-facing surface designed for the attachment of the joint implant to a bone and a hydrogel-facing surface designed for the attachment to a hydrogel component, wherein at least part of the hydrogel-facing surface is designed as a porous triply periodic minimal surface. The bonding between the hydrogel and the anchoring element is achieved through chemical anchoring and mechanical hooking mechanisms.

IPC Classes  ?

• A61F 2/30 - Joints
• A61F 2/32 - Joints for the hip
• A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs

Abstract

The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH, and (b) adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry. The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH, and (b) adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/38 - Animal cells
• A61L 27/52 - Hydrogels or hydrocolloids
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/0793 - Neurons

Abstract

The present invention relates to a method of obtaining keratin protein isolate from a keratin source, the method comprising: (a) preparing a first mixture comprising keratin source, chaotropic solvent, and a first reducing agent; (b) precipitating keratin protein from the first mixture; (c) preparing a second mixture comprising the keratin protein and a second reducing agent; and (d) precipitating keratin protein isolate from the second mixture. The present invention also relates to a method of obtaining keratin amyloid fibrils, the method comprising: (i) obtaining keratin protein isolate; (ii) preparing a third mixture comprising keratin protein isolate, acid solution, and a third reducing agent; and (iii) subjecting the third mixture to heat treatment to obtain keratin amyloid fibrils. The present invention also relates to a method of fabricating a membrane for an electrochemical cell or a proton conductive cell.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C08L 89/04 - Products derived from waste materials, e.g. horn, hoof or hair
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
• H01M 8/1069 - Polymeric electrolyte materials characterised by the manufacturing processes
• H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking

Abstract

A method for producing a nano- or micro-sheet element is provided, the nano- or microsheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising at least a growth substrate (1) and a nano- or micro-sheet layer (2). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2). In the electrochemical delamination of the laminate (14), a gas diffusion electrode (21) attached to the nano- or micro-sheet layer (2) is used as an anode and an electrolyte membrane, in particular a polymer electrolyte membrane (20), is arranged between the gas diffusion electrode (21) and the nano- or micro-sheet layer (2).

IPC Classes  ?

• C25B 13/05 - DiaphragmsSpacing elements characterised by the material based on inorganic materials
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/032 - Gas diffusion electrodes
• C25B 13/02 - DiaphragmsSpacing elements characterised by shape or form

Abstract

The invention relates to a method, system and computer program for determining a tracer flow in a measurement space, the method comprising the steps of: a) Injecting tracers at a first injection region into the measurement space with a tracer seeding device configured to inject tracers at an adjustable injection region in the measurement space, b) Recording the measurement space with two or more event-cameras, wherein each event-camera comprises a plurality of sensors configured to generate output data each time a sensor of the event camera senses a change in light intensity, wherein the output data comprises an information on a position of the sensor that sensed the change in light intensity, and a time of the change in light intensity, c) From the data of the event-cameras, determining with a processor for at least some of the injected tracers a trajectory in the measurement space, wherein each trajectory comprises at least an information on a time-resolved three-dimensional position of the tracer, wherein the determination of the trajectories is facilitated in real time, d) While executing steps b) and c), adjusting the injection region to at least a second injection region.

IPC Classes  ?

• G01P 5/20 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the time taken by the fluid to traverse a fixed distance using particles entrained by a fluid stream
• G01P 5/00 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft
• G06F 30/20 - Design optimisation, verification or simulation
• H04N 25/47 - Image sensors with pixel address outputEvent-driven image sensorsSelection of pixels to be read out based on image data

Abstract

The present invention relates to a micro-foamed cheese product and a method of producing a micro-foamed cheese product comprising providing an extruder having a gas loading zone applying a milk protein coagulate comprising milk protein, water and at least 0.8% (w/w) fat relative to the wet weight of the milk protein coagulate into the inlet of the extruder; rotating the longitudinally arranged screw to create a flow of the milk protein coagulate from the inlet to the outlet; heating the milk protein coagulate to 60°C to 140°C to melt the milk protein coagulate; dispersing a gas in the molten milk protein coagulate in the gas loading zone; and cooling the molten milk protein coagulate to obtain the micro-foamed foamed cheese product.

IPC Classes  ?

• A23C 19/02 - Making cheese curd
• A23C 19/06 - Treating cheese curd after whey separationProducts obtained thereby
• A23C 19/082 - Adding substances to the curd before or during meltingMelting salts
• A23P 30/20 - Extruding
• A23P 30/40 - Foaming or whipping

Abstract

An electronic device (1) comprises a time-modulated receiver array (RX) or a beamforming network (BFN) connected with a time-modulated transmitter array (TX), wherein the time-modulated transmitter array (TX) includes a plurality of switches (ST1, . . . , STN) which are periodically operable between an on state (1) and an 5 off state (0) for periodic signal transmission to a plurality of antenna elements (AT1, . . . , ATN).

IPC Classes  ?

• G01S 7/03 - Details of HF subsystems specially adapted therefor, e.g. common to transmitter and receiver

Abstract

The present invention is generally in the fields of synthetic biology, gene therapy, and cell therapy. The invention relates, inter alia, to a synthetic transcription factor comprising a DNA binding domain derived from a mitochondrial DNA binding protein (e.g. MTERF1) and a transcriptional modulation domain derived from one or more other proteins; a nucleic acid or combination of nucleic acids encoding the inventive synthetic transcription factor; a DNA construct comprising a MTERF1 binding site and a minimal promoter; a system comprising the inventive synthetic transcription factor and the inventive DNA construct; and uses thereof, e.g. medical uses.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

A recombinant non-naturally occurring methylotrophic microorganism, which grows on reduced one-carbon (C1) compounds as sole carbon source. The recombinant microorganism expresses or over-expresses a polypeptide having methanol dehydrogenase activity, a polypeptide having 3-hexulose-6-phosphate synthase activity, and polypeptide having a 6-phospho 3-hexuloisomerase activity, and does not comprise, and/or comprises deletions or reductions of expression of, or eliminations or reductions of activity of a polypeptide having triose-phosphate-isomerase activity, and of a polypeptide having glutathione-dependent formaldehyde dehydrogenase activity.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 9/90 - Isomerases (5.)
• C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
• C12R 1/19 - Escherichia coli

Abstract

A method for producing a nano- or micro-sheet element is provided, the nano- or micro-sheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising a growth substrate (1), a nano- or micro-sheet layer (2) and a support layer (3). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2) and the support layer (3). The step of electrochemical delamination of the laminate (14) is carried out with the support layer (3) having a pattern (31) with a plurality of local depressions (311) and/or elevations (312).

IPC Classes  ?

• C01B 32/19 - Preparation by exfoliation
• C25D 1/00 - Electroforming
• C25D 1/20 - Separation of the formed objects from the electrodes
• C25D 17/00 - Constructional parts, or assemblies thereof, of cells for electrolytic coating
• C25D 17/12 - Shape or form

Abstract

Methods and systems for animated figure keyframing or physical robot keyframing and learning locomotion with high-level objectives are discussed herein. For example, generating motion for an animated figure may include generating a control policy for the animated figure using a reinforcement learning model, wherein the control policy is configured to control a movement of the animated figure to achieve one or more keyframes. Generating motion for the animated figure may further include encoding the control policy onto a processor of the animated figure. In some cases, the control policy for the animated figure may be generated using a multi-input single-output transformer encoder. Generating motion for the animated figure further includes determining one or more target keyframes and generating, using the control policy, the motion for the animated figure based on the one or more target keyframes.

IPC Classes  ?

• B25J 9/16 - Programme controls
• G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric

Abstract

The present invention relates to 4-oxoretinoate for use in treatment or prevention of cardiac dysfunction, heart failure, or adverse cardiac remodelling after myocardial infarction or impaired cardiac blood flow. The present invention also relates to 4-oxoretinoate for use in treatment of coronary artery disease, or of ischemia-reperfusion injury.

IPC Classes  ?

• A61K 31/203 - Retinoic acids
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

nn-R with Ar, X, n and R as defined in the specification, particularly the UV absorbing agent is cinnamic acid, cinnamyl alcohol or gallic acid, or a derivative thereof. The invention further relates to a substrate comprising a coating and a method for protecting a surface of a substrate from UV electromagnetic radiation.

IPC Classes  ?

• C09D 5/32 - Radiation-absorbing paints
• C09D 7/48 - Stabilisers against degradation by oxygen, light or heat
• C09D 15/00 - Woodstains
• C09D 193/02 - Shellac

Goods & Services

Sound, image or data broadcasting, reproducing or processing apparatus; downloadable and recorded media; downloadable videos, images, publications and books. Printing products (printed matter); books; instructional and teaching material. Teaching; training services; entertainment services; sporting and cultural activities; exhibition curating services; presentation of museum exhibitions; museum services; organization and presentation of exhibitions for cultural purposes; cultural, educational and entertainment services provided by art galleries; editing services; publication of books; online provision of non-downloadable books, publications, images and videos; online provision of virtual guided tours; training and advice concerning methods and techniques aimed at stimulating personal creativity; development and conducting of art projects and exhibitions for third parties. Scientific and technological services as well as research and design relating thereto in the field of art and artificial intelligence; advice with respect to artificial intelligence.

Abstract

A rocking bed comprising a slider-crank mechanism comprising a rotary drive and at least one four-bar linkage comprising a frame with two cranks pivotably mounted thereon via a first pivot and a second pivot, and a movable linkage pivotably connected to the cranks via a third pivot and a fourth pivot. A connecting rod of the slider-crank mechanism is pivotably connected to a support structure of the rocking bed via a sixth pivot, wherein there is a pivotable connection between the movable linkage and the support structure of the rocking bed via a fifth pivot, via which a movement of the support structure can be guided along a horizontal direction. The rotary drive has a control unit configured to realize a revolution operation of a crank of the slider-crank mechanism. A method and a computer program for operating such a rocking bed are also provided.

IPC Classes  ?

• A47C 21/00 - Attachments for beds, e.g. sheet holders or bed-cover holders Ventilating, cooling or heating means in connection with bedsteads or mattresses

Abstract

Sensors suitable to be used for wearable electronic devices. The sensor are flexible or stretchable and can be seamlessly incorporated into textiles, clothing, and wearable devices. The sensor uses helical-auxetic yarns for construction of a capacitor. The sensors can be stretchable and are suitable for use in textiles and for sensing body motion (strain).

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators

Abstract

The present invention is directed to a method for manufacturing a bioresorbable polymeric medical implant and a polymeric composition for use in such a method. The inventive polymer blend comprises a PCL/PLA mixture in solution, and further comprises a compatibilizer. The inventive method comprises producing the inventive polymeric composition, and using said polymeric composition to form the selected implant, followed by heat treatment.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 31/14 - Materials characterised by their function or physical properties
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• C08G 63/08 - Lactones or lactides

Abstract

A photodetector (PD), comprises: a photonic layer (1) which includes a widening section (12) followed by a wide section (13), wherein the widening section (12) is configured to receive an optical signal (oS) and to distribute optical power of the optical signal (oS) to the wide section (13); a spacer layer (2) which is in contact with the wide section (13); a 2D material layer (3) which is in contact with the spacer layer (2); a plasmonic layer (4) which is in contact with the 2D material layer (3) and includes a plurality of plasmonic resonators (411, 421) which are connected via contact lines (412, 422) to connector lines (413, 423), wherein the connector lines (413, 423) enable to measure charge carriers which are generated upon receipt of the optical signal (oS).

IPC Classes  ?

• H10F 30/22 - Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
• H10F 77/14 - Shape of semiconductor bodiesShapes, relative sizes or dispositions of semiconductor regions within semiconductor bodies
• H10F 77/40 - Optical elements or arrangements
• G02B 6/42 - Coupling light guides with opto-electronic elements

Abstract

The present invention relates to the provision of trifunctional crosslinker compounds comprising (i) a moiety reactive with an amino acid side chain for selective labelling of proteins, (ii) a cleavable linker moiety and (iii) an affinity moiety for the detection, isolation and purification of captured proteins. The invention further relates to uses of the cleavable crosslinking reagents in methods for detecting, labelling, identifying and characterizing proteins and protein interactions in or on the surface of intact cells, cell lysates and/or protein mixtures.

IPC Classes  ?

• C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
• C07K 5/04 - Peptides having up to four amino acids in a fully defined sequenceDerivatives thereof containing only normal peptide links
• C07K 1/13 - Labelling of peptides
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes

Goods & Services

Recorded and downloadable media; computer software; computer software for accessing computer networks and downloadable information provided by computer networks; software platforms; software for managing communication systems and networks; computer software for providing online services for social and business networks and for accessing, uploading, downloading, sending, managing, streaming, sharing or providing electronic works and information via the Internet or communication networks; software for creating virtual communities; software for the transmission of information, audio and video data, photographic images, texts and graphics; algorithms (software). Advertising; business management, organization and administration; creation and management of an online business network for professional contacts; establishing networks of business partners; business intermediation services; commercial intermediation services matching potential investors with companies seeking capital; matching students and researchers with business industry representatives and investors; services related to business networking; business information provided via a database or an online electronic platform in a computer network; compilation and systematization of data in databases and digital platforms containing information relating to business networks and work collaborations; providing business information by means of a directory on a global computer network; provision of an online marketplace; organization of competitions and awarding of prizes for commercial or advertising purposes; provision of an electronic marketplace for buyers and sellers of goods and services; compilation and systematization of data in a database containing information relating to academic research and development and to a virtual academic community. Financial services; online bill payment services; sponsorship in the form of financial support; financial promotion; financial sponsorship in the fields of culture, sports, science, education, development aid and research; crowdfunding; provision of investment capital and funds for inventors, companies and universities; providing information on cooperation and investment opportunities via online searchable digital platforms and databases. Telecommunication services; providing telecommunications connections to computer networks; providing access to computer networks, digital platforms, databases, electronic marketplaces and electronic publications; providing chat rooms and online forums in virtual environments and access thereto; providing access to digital platforms, chat rooms and online forums in virtual environments for work collaborations; providing access to digital platforms, chat rooms and online forums in virtual environments for The transmission of messages relating to academic research and development and virtual communities, including business networks; providing access to electronic bulletin boards for transmission of messages among users; providing multiple-user access to a global computer network; provision of chat rooms for social networks as well as access thereto; transmission of information on a wide range of topics, also online and via a global computer network; rental and free provision of access time to data networks and digital platforms for information and announcements relating to academic research and development, virtual communities, work collaboration networks and collaborations. Education; training; entertainment; sporting and cultural activities; organization and conducting of competitions via the Internet; organizing training and entertainment competitions; entertainment services provided online in the form of chat rooms. Scientific and technological services as well as research work and design services relating thereto; industrial analysis, industrial research and industrial design services; design, development, provision and hosting of digital platforms and Websites, including interactive sites, for work collaborations in virtual environments; design and development of computer hardware and software; design, development and provision of non-downloadable software for computer networks and digital platforms enabling users to post, search, access, share and exchange electronic content and information; computer services, namely, technological services for creating an on-line community for users to participate in networks; development and provision of software applications relating to virtual communities and social networks; creating an online community for users to participate in networks; providing software applications for participating in discussions, exchanges, returns, creating virtual communities and participating in networks; development and testing of algorithms, calculation methods and software. Legal services; legal assistance in the drawing up of contracts; legal services relating to licenses; moderation of contents for Internet chat rooms.

Abstract

System for producing somatotopic sensations using Transcutaneous Electrical Nerve Stimulation (TENS) in the lower limbs is provided, the system comprising a wearable device to be attached to a lower limb of an individual, the wearable device comprising at least two units, each comprising one or more arrays of TENS electrodes to be associated with at least one nerve of the lower limb, and wherein the system is configured to select electrodes of at least one array of electrodes, and stimulation signal parameters to be thereto, and control the stimulation of at least one nerve associated with the array of electrodes comprising the selected electrodes.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/02 - ElectrotherapyCircuits therefor Details
• A61N 1/04 - Electrodes

Abstract

A DNA sequence and a synthetic gene circuit (SGC) comprising the same for detecting a DNA or RNA nucleotide trigger sequence, associated detection systems, methods for detecting the DNA or RNA nucleotide trigger sequence as well as further proteins of interest and associated uses.

IPC Classes  ?

• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

An arrangement for additive manufacturing of a structure, preferably an architectural structure, the arrangement comprising a nozzle having a construction material outlet configured to extrude construction material in the form of a hollow core bead along a manufacturing path defined by multiple points, a fluid outlet configured to inject a fluid into the hollow core of the extruded bead, a fluid pressure adjusting device configured to adjust a pressure of the fluid injected into the hollow core of the extruded bead via the fluid outlet, and a control unit configured to determine a pressure value assigned to a point of the manufacturing path and to control the fluid pressure adjusting device on the basis of the determined pressure value. Furthermore, a method for generating control data for such an arrangement is disclosed.

IPC Classes  ?

• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B29C 64/209 - HeadsNozzles
• B29C 64/295 - Heating elements
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes

Abstract

Described is a method of preparing foams, wherein a suspension comprising an aqueous liquid, particles and at least one surfactant is provided, wherein the at least one surfactant at least partially hydrophobizes a surface of the particles, and wherein the suspension comprising the particles having the at least partially hydrophobized surface is foamed. The at least one surfactant is selected from surfactants having a backbone chain comprising at least nine carbon atoms, the at least one surfactant preferably being an amphiphilic molecule consisting of a tail coupled to a head group, wherein the tail comprises the backbone chain comprising at least nine carbon atoms.

IPC Classes  ?

• C04B 38/10 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by using foaming agents
• C04B 14/04 - Silica-rich materialsSilicates
• C04B 18/08 - Flue dust
• C04B 28/04 - Portland cements
• C04B 28/26 - Silicates of the alkali metals
• C04B 103/40 - Surface-active agents Dispersants
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

The invention relates to a ULK1 inhibitor for use in the treatment of a human or mammalian patient being diagnosed for, suffering from, or being at risk of developing a neurodegenerative disease, or in the prevention of such condition.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

aacdcc) of the fluid channel (111).

IPC Classes  ?

• F23R 3/28 - Continuous combustion chambers using liquid or gaseous fuel characterised by the fuel supply

Abstract

A steerable device includes an elongated element configured to be navigated through the mammalian body. The elongated element has a device tip configured for allowing steering of the elongated element by way of an external magnetic field. Further, the device tip includes a plurality of segments, each segment including a segment body and a segment interface, and a plurality of connectors, each connector including a connector body and a connector interface. The connector interfaces and the segment interfaces have each time mutually complementing shapes allowing rotational movements relative to each other and forming a connection to retain the connectors and the segments in a mated condition, and the magnetic elements form at least partially segment bodies or connector bodies or both.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/005 - Flexible endoscopes
• A61B 1/008 - Articulations
• A61M 25/00 - CathetersHollow probes
• A61M 25/06 - Body-piercing guide needles or the like

Abstract

The invention refers to an apparatus for powder-based additive manufacturing of three-dimensional structures on a platform (4). The apparatus comprises a powder delivery mechanism (100) with a first powder chamber (11) for a first powder with a first powder outlet, and a second powder chamber (12) for a second powder with a second powder outlet. In addition, the powder delivery mechanism (100) comprises a gating mechanism (3) with a first slot (31) and a second slot (32), wherein the powder delivery mechanism (100) and/or the platform (4) are rotatable around a platform center axis (10) of the platform (4), wherein the gating mechanism (3) is arranged such that the first slot (31) defines an outlet surface of the first powder outlet and the second slot (32) defines an outlet surface of the second powder outlet, wherein the gating mechanism (3) is displaceable relatively to the first powder outlet and/or the second powder outlet.

IPC Classes  ?

• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
• B22F 12/00 - Apparatus or devices specially adapted for additive manufacturingAuxiliary means for additive manufacturingCombinations of additive manufacturing apparatus or devices with other processing apparatus or devices
• B22F 12/37 - Rotatable
• B22F 12/55 - Two or more means for feeding material
• B22F 12/57 - Metering means
• B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 40/00 - Auxiliary operations or equipment, e.g. for material handling
• B29C 64/205 - Means for applying layers
• B29C 64/241 - Driving means for rotary motion

Abstract

The present invention relates to a combination therapy against pathogenic bacteria in the gut, wherein a bacteriophage against the capsule of the pathogenic bacterium is combined with a vaccination against a bacterial antigen which is normally masked by the capsule.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• A61K 39/112 - SalmonellaShigella
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to a method for screening engineered antibody Fc regions having modified Fc receptor binding properties, the method comprising the steps of: (a) providing a plurality of cells displaying engineered antibody Fc regions on their cell surface, preferably wherein each cell comprised in the plurality of cells displays an engineered antibody Fc region comprising at least one mutation; (b) contacting the cells in step (a) with an Fc receptor; (c) separating cells that have been contacted with the Fc receptor in step (b) into two or more cell populations according to their ability to bind to the Fc receptor, preferably wherein the ability of an engineered antibody Fc region to bind to the Fc receptor is determined by comparison with a reference antibody Fc region; and (d) sequencing cells from at least one of the populations obtained in step (c), preferably to identify mutations in the engineered antibody Fc region that (i) confer improved binding to the Fc receptor, (ii) do not affect binding to the Fc receptor, and/or (iii) confer reduced binding to the Fc receptor. Further provided herein are methods for predicting the Fc receptor binding properties of an engineered antibody Fc region, as well as methods for generating an engineered antibody Fc region having desired Fc receptor binding properties

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relates to a process for the stereoselective preparation of such compounds. The compound of formula (I) can be used as a medicament, in particular for inhibiting coronin 1 expression in the induction of immunosuppression or in the treatment and/or prevention of a disease or disorder selected from the group consisting of transplant rejection, autoimmune diseases, inflammatory diseases, infectious diseases, and lymphoproliferative disorders. The present invention further relates to a vector comprising a coronin 1 promoter element, wherein in a vertebrate genome, said coronin 1 promoter element starts directly upstream from a transcription starting site (TSS) of a coronin 1 gene and spans a sequence stretch of at least about 700 bp in said genome. The present invention further relates to a method using said vector for identifying immunomodulatory compounds that alter the coronin 1 promoter activity. The present invention further relates to BRD3 as an upstream target responsible for driving the coronin-1 expression and activity in immune cells, and relates to compounds, in particular compound of formula (I), that selectively target bromodomains of BRD3 and thereby deplete coronin 1 levels. The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relates to a process for the stereoselective preparation of such compounds. The compound of formula (I) can be used as a medicament, in particular for inhibiting coronin 1 expression in the induction of immunosuppression or in the treatment and/or prevention of a disease or disorder selected from the group consisting of transplant rejection, autoimmune diseases, inflammatory diseases, infectious diseases, and lymphoproliferative disorders. The present invention further relates to a vector comprising a coronin 1 promoter element, wherein in a vertebrate genome, said coronin 1 promoter element starts directly upstream from a transcription starting site (TSS) of a coronin 1 gene and spans a sequence stretch of at least about 700 bp in said genome. The present invention further relates to a method using said vector for identifying immunomodulatory compounds that alter the coronin 1 promoter activity. The present invention further relates to BRD3 as an upstream target responsible for driving the coronin-1 expression and activity in immune cells, and relates to compounds, in particular compound of formula (I), that selectively target bromodomains of BRD3 and thereby deplete coronin 1 levels.

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• C07D 215/54 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 493/04 - Ortho-condensed systems
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Provided herein are compounds comprising an isopeptide-linked lysine or an analog thereof. Further provided herein are methods for engineering peptide-binding proteins having increased affinity and/or selectivity for the compound according to the invention, as well as peptide-binding proteins with increased selectivity for the compound according to the invention. Moreover, methods for incorporating non-canonical amino acids into proteins are provided herein.

IPC Classes  ?

• C07K 5/02 - Peptides having up to four amino acids in a fully defined sequenceDerivatives thereof containing at least one abnormal peptide link
• C07K 14/245 - Escherichia (G)
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Abstract

A measurement assembly for determining refractive index changes in a sample comprises a light source (2), a tunable wavelength selector (3), an image sensor (4), a processing unit (6), and a Fabry-Perot unit (5) comprising a first plane surface (51) and a second plane surface (52), the Fabry-Perot unit (5) having a sample reception space (53) arranged between the first plane surface (51) and the second plane surface (52) to receive a sample. The Fabry-Perot unit (5) is arranged to act as a wavelength-dependent light intensity filter. The image sensor (4) is configured to record a two-dimensional image of the sample reception space for different spectral subranges and the processing unit (6) is configured to reconstruct the intensity filter function of the Fabry-Perot unit (5) based on the recorded two-dimensional images, and to determine a refractive index map based on the reconstructed intensity filter function.

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/03 - Cuvette constructions

Abstract

A solar receiver having an enclosure delimiting a cavity that is configured to receive a heat transfer fluid, at least one opening in the enclosure for access of solar radiation into the cavity, at least one window that seals the opening, and at least one cooling device that is configured to cool the window. The cooling device is configured to supply at least one window-cooling liquid fluid to the window, such that the window-cooling liquid fluid forms at least one liquid layer on and/or in the window.

IPC Classes  ?

• F24S 40/55 - Arrangements for cooling, e.g. by using external heat dissipating means or internal cooling circuits
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 80/50 - Transparent coveringsElements for transmitting incoming solar rays and preventing outgoing heat radiation

Abstract

An apparatus for liquid handling, in particular of small liquid volumes, an associated method and use for liquid handling, in particular for receiving and/or dispensing a liquid, the apparatus comprising: a capillary; a plate; means for moving the capillary and/or the plate relative to each other; and a sensor (9).

IPC Classes  ?

• B01L 3/02 - BurettesPipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A pupillometry system (100) for computer-implemented assessment of brain aging and presymptomatic Alzheimer's risk in cognitively unimpaired individuals through computer-human interaction with a user (5), wherein the pupillary moment-by-moment dynamics of the user on a sensory stimulation decision task with continuous or—at least two—discrete selection options and a subsequent reward/feedback choice is analyzed.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A connector assembly (100) for connecting external power sources to an implanted medical device has a distal driveline portion (102) and a proximal driveline portion (101), each comprising a plurality of isolated electricity wires (103) and at least one load carrying wire (104). An intermediate driveline assembly (300) is provided and adapted to arrange the electricity wires (103) and the load carrying wire(s) (104) in a flat plane (13) for a predetermined distance (11) in the longitudinal direction (10) of these wires (103, 104), wherein the electricity wires (103) and the load carrying wire(s) (104) are positioned in a spacing from each other over at least a part of this predetermined distance (11') in that plane (13).

IPC Classes  ?

• A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
• A61M 60/878 - Electrical connections within the patient’s body
• A61M 60/88 - Percutaneous cables
• A61M 39/10 - Tube connectors or tube couplings

Abstract

The present invention relates to a device (1) for reducing a particle density of a sample of a suspension of particles in a liquid, the device comprising a measurement flow path (13) for characterizing the sample of the suspension, wherein the device (1) is configured to withdraw a sample of the suspension residing in a main vessel (100), and to dilute the sample, particularly when a measure indicative of the particle density in the sample is above a pre-defined threshold.

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples
• G01N 15/0227 - Investigating particle size or size distribution by optical means using imagingInvestigating particle size or size distribution by optical means using holography
• G01N 15/075 - Investigating concentration of particle suspensions by optical means

Abstract

The present invention relates to a specific lipid emulsion comprising ≥ 5 % stearidonic acid and ≥ 15 % α-linolenic acid for use in neuroprotection, neuroregeneration and neurodevelopment.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
• A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A computer implemented method for determining a representation which indicates the activity of a locus coeruleus system of a user. The method includes the steps of, measuring the size of a pupil of a user; providing a representation the appearance of which is based on the measured size of the pupil; and either, providing an audio stimulus designed to decrease or increase the activity of the user's locus coeruleus system when heard by the user, wherein the content of the audio stimulus is dependent on the measured size of the pupil of the user, or, providing a haptic stimulus designed to decrease or increase the activity of the user's locus coeruleus system when heard by the user. Characteristics of the haptic stimulus are dependent on the measured size of the pupil of the user. Also methods estimate the activity of a locus coeruleus system of a user.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I) A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I) A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I) and a second monomer of the general formula (II) A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I) and a second monomer of the general formula (II) A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I) and a second monomer of the general formula (II) wherein Y is selected from the group consisting of —CH2Z3, —NHCOR5, —CONHR6, —OCOR7, —COOR8 and —OR9, and where Z1, Z2, and Z3 are selected from the group consisting of fluoro, chloro, bromo, iodo, hydroxyl, toluene-4-sulfonyloxy and methylsulfonyloxy. R1, R2, R3 and R4 are independently from each other selected from the group consisting of linear or branched C1-C30 alkyl, a linear or branched C2-C30 alkenyl, a linear or branched C2-C30 alkynyl, sulfo, nitro, amino, hydroxy, oligo(C2 to C4-alkylene glycol), —NHCOR5, —CONHR6, —OCOR7, —COOR8 and —OR. R5, R6, R7, R8 and R9 are selected from the group consisting of a linear or branched C1-C30 alkyl, a linear or branched C2-C30 alkenyl and a linear or branched C2-C30 alkynyl.

IPC Classes  ?

• C08G 61/10 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
• C09D 5/03 - Powdery paints
• C09D 5/08 - Anti-corrosive paints
• C09D 7/20 - Diluents or solvents
• C09D 165/02 - Polyphenylenes

Abstract

The invention relates to a method, particularly a computer-implemented method for determining a fatigue value of a person, the method comprising the steps of: i) displaying of: a) a first group (1) of symbols and a second group (2) of symbols, b) a selection rule (3) associating each of the symbols of the first group (1) of symbols to one symbol of the second group (2) of symbols, ii) highlighting one symbol (11) of the first group (1) of symbols, iii) receiving a user input from the person selecting one symbol (12) of the second group (2) of symbols, iv) determining a truth value based on the selected symbol (12) of the second group (2) of symbols, wherein the truth value assumes a true value if the selected symbol (12) is selected in accordance with the selection rule (3) and wherein the truth value takes on a false value if not, wherein the highlighted symbol (11) of the first group (1) of symbols is highlighted for a predetermined time based on a statistical response time of the person, and wherein if the user input is not received within the predetermined time in step iv), the method is set forth with step v) having the truth value set to the false value, or the method is set forth with step vi), v) storing the truth value on a non-transitory memory device, vi) changing the selection rule (3), such that each of the symbols of the first group (1) of symbols is associated anew to one symbol of the second group (2) of symbols, vii) changing the highlighted symbol (11) of the first group (1) of symbols, viii) repeating steps iii) to vii) at least once and ix) based on at least some of the stored truth values, determining a fatigue value of the person.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A method for changing an inter-particle distance (D) between particles (1) arranged in a particle array (2) is provided, the method comprises creating a primary optical lattice (10), loading the particles (1) into the primary optical lattice (10) such that the particles (1) are trapped in the primary optical lattice (10), changing a primary-lattice spacing (L1) of the primary optical lattice (10) to change the inter-particle distance (D), creating an auxiliary optical lattice (20), ramping up the auxiliary-lattice and ramping down the primary optical lattice until the particles (1) are trapped in the auxiliary optical lattice (20), setting the primary-lattice spacing (L1) to a different primary-lattice spacing value, ramping up the primary-lattice and ramping down the auxiliary lattice (20) until the particles are trapped in the primary optical lattice (10) again.

IPC Classes  ?

• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

An assay device (1) for electrochemical sensing of a sample fluid comprises, at least one substrate (2), at least one electrode (3), and at least one channel (5). The channel (5) extends at least partially in the substrate (2) and is configured to receive the sample fluid. At least part of the electrode (3) is arranged in the channel (5) and is configured to detect at least one electrical property being associated with the sample fluid. The substrate (2), at least in the region of the channel (5), is porous. At least the part of the electrode (3) being arranged in the channel (5) is porous. The substrate (2) is configured to exert a capillary force onto the sample fluid in the channel (5) such that the sample fluid is flowing through the part of the electrode (3) being arranged in the channel (5).

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes

Abstract

The present invention relates to an expression system and a method ensuring constant-level concentration of an output. The invention also relates to a cell comprising the expression system.

IPC Classes  ?

• C12N 15/67 - General methods for enhancing the expression
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

The present invention relates to systems and reactors for continuous production of ammonia. The systems are particularly suited to produce ammonia in decentralized, rural locations using temporal surplus electricity from renewable sources, thereby allowing the production of fertilizers in the location of need.

IPC Classes  ?

• C01C 1/04 - Preparation of ammonia by synthesis
• B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds

Abstract

The invention pertains to a method for controlling a reaction of a CRISPR Cas effector protein with a target, an associated CRISPR Cas effector protein and associated uses for detection, optionally detection of a nucleic acid in a biological sample or in a sample derived from a biological material.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 9/96 - Stabilising an enzyme by forming an adduct or a compositionForming enzyme conjugates

Abstract

The present invention relates to a method for dechlorinating chlorinated organic compounds in an electrochemical device comprising an undivided electrolytic cell with two electrodes acting as anode and cathode, by a) providing a composition comprising the chlorinated organic compounds, a solvent and a sacrificial electron donor, wherein the solvent can also function as the sacrificial electron donor, or alternatively, the solvent and the sacrificial electron donor are two separate components, and b) conducting an electrochemical reaction to dechlorinate the chlorinated organic compounds, characterized by alternating the polarity of the two electrodes, with both electrodes being graphite electrodes.

IPC Classes  ?

• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection
• C02F 1/68 - Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
• C02F 101/36 - Organic compounds containing halogen
• C02F 101/30 - Organic compounds
• C02F 101/34 - Organic compounds containing oxygen
• C02F 103/06 - Contaminated groundwater or leachate

Abstract

The invention relates to a method for making a micro-structured hydrogel, comprising the steps of: providing a hydrogel composition comprising a polymer crosslinked by linker moieties comprising a photolabile coumarin moiety, and subjecting the hydrogel composition to structured irradiation with light having a wavelength of ≥700 nm. The invention also relates to a micro-structured hydrogel composition, comprising a hydrogel crosslinked by moieties comprising a photolabile moiety susceptible to cleavage by two-photon irradiation of a wavelength of ≥700 nm, and channels or cavities having a diameter of ≤10 µm. In some embodiments, the hydrogel comprises a plurality of ellipsoid indentations (lacunae) on its surface, and a plurality of channels (canaliculi) departing from each lacuna.

IPC Classes  ?

• C08B 37/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08J 3/28 - Treatment by wave energy or particle radiation
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C07D 311/08 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
• C08G 65/48 - Polymers modified by chemical after-treatment
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

A gyrotron system (1) comprises a housing (2), an electron gun (3) configured to produce an electron beam, at least one magnet (4) configured to produce a magnetic field, and a cavity (5) configured to receive the electron beam, and wherein microwaves and/or Terahertz waves (16) are generatable in the cavity (5) by a resonance coupling between the electron beam and the magnetic field produced by the magnet (4). The magnet (4) is a superconducting magnet that is configured to exhibit superconductivity upon cooling below its critical temperature and that is arranged around the cavity (5), and the cavity (5) and the superconducting magnet (4) are arranged within the housing (2).

IPC Classes  ?

• H01J 23/00 - Details of transit-time tubes of the types covered by group
• H01J 23/087 - Magnetic focusing arrangements
• H01J 23/12 - VesselsContainers
• H01J 25/02 - Tubes with electron stream modulated in velocity or density in a modulator zone and thereafter giving-up energy in an inducing zone, the zones being associated with one or more resonators

Abstract

Method for calculating NH3 and NOx concentrations downstream from an SCR system of an internal combustion engine (E) of a vehicle by means of a statistical module, the method comprising the following steps: using temperature measurements acquired upstream (T1) and downstream (T2) of the Selective Reduction Catalyst (SCR) as first input variables and NOx mass flow measurements acquired upstream (N1) and downstream (N2) of the SCR as second input variables; calculating an NH3 concentration downstream from the SCR catalytic converter as a function of the first and second inputs.

IPC Classes  ?

• F01N 9/00 - Electrical control of exhaust gas treating apparatus

Abstract

A method of producing a deposition structure (1) on a substrate (2) comprises the steps of i) providing at least one depositor (3) for depositing at least one material (6), ii) providing at least one mask (4) comprising a plurality of apertures (5, 5a,...), iii) providing at least one substrate (2), and iv) depositing at least one material (6) from the depositor (3). Part of the material (6) passes through the apertures (5, 5a,...) of the mask (4) and is deposited on a surface (7) of the substrate (2), whereby at least one deposition structure (1) is formed on the surface (7) of the substrate (2). At least one tilting angle (φ) between i) the substrate (2) and/or the mask (4) and ii) the depositor (3) is at least temporarily changed before and/or during the deposition of the material (6). Additionally or alternatively, at least one rotating angle (θ) between i) the substrate (2) and/or the mask (4) and ii) the depositor (3) is at least temporarily changed before and/or during the deposition of the material (6).

IPC Classes  ?

• C23C 14/04 - Coating on selected surface areas, e.g. using masks
• C23C 14/22 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
• C23C 14/52 - Means for observation of the coating process
• C23C 14/54 - Controlling or regulating the coating process
• H01L 21/308 - Chemical or electrical treatment, e.g. electrolytic etching using masks
• H05B 33/10 - Apparatus or processes specially adapted to the manufacture of electroluminescent light sources
• H10K 71/16 - Deposition of organic active material using physical vapour deposition [PVD], e.g. vacuum deposition or sputtering
• G03F 9/00 - Registration or positioning of originals, masks, frames, photographic sheets or textured or patterned surfaces, e.g. automatically
• B82Y 40/00 - Manufacture or treatment of nanostructures

Goods & Services

Scientific, research, navigation, surveying, photographic, cinematographic, audiovisual, optical, weighing, measuring, signaling, detecting, testing, inspecting, life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity distribution or use; apparatus and instruments for sound, image or data recording, transmission, reproduction or processing; recorded and downloadable media, software, blank digital or analog recording and storage media; computers and computer peripheral devices; software for computers; web application software; recorded and downloadable computer programs and computer software enabling common use and collaborative development of computer software, computer code and user-created content; recorded and downloadable data, namely weightings, parameters and meta-parameters of artificial intelligence models; recorded and downloadable data, namely weightings, parameters and meta-parameters of artificial intelligence models for creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; recorded and downloadable computer programs and recorded and downloadable computer software for artificially creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; recorded and downloadable pretrained data, namely, neural network weightings, parameters and meta-parameters for large language models for automatically creating, recognizing, translating, processing, understanding, generating and analyzing spoken language, texts and language; downloadable computer programs and downloadable computer software for simulating conversations. Telecommunications; providing access to websites, platforms, portals, databases, computer programs, web applications and data via computer or data networks or using information technology and telecommunication networks; transmitting, broadcasting and receiving audio, video content, still and moving images, text and data via computer or data networks or using information technology and telecommunication networks; transmitting web applications via the Internet; rental and provision of free access time to global computer networks and databases. Teaching; training; provision of entertainment; cultural activities. Scientific and technological services as well as research and design services relating thereto; industrial analysis, industrial research and industrial design services; quality control and authentication services; design and development of computer hardware and software; software engineering; research and development in the field of artificial intelligence; technical advisory services in the field of artificial intelligence; design of computer-simulated models; developing web applications; providing non-downloadable web applications; developing computer programs and computer software for common use and collaborative development of computer software, computer code and user-created content; providing computer programs and non-downloadable computer software enabling common use and collaborative development of computer software, computer code and user-created content; information technology services, namely development of weightings, parameters and meta-parameters for artificial intelligence models; providing software for developing weightings, parameters and meta-parameters for artificial intelligence models; providing non-downloadable weightings, parameters and meta-parameters for developing artificial intelligence models (information technology services); information technology services, namely developing weightings, parameters and meta-parameters for artificial intelligence models for creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; providing software for developing weightings, parameters and meta-parameters for artificial intelligence models for creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; providing non-downloadable weightings, parameters and meta-parameters for developing artificial intelligence models for creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts (information technology services); developing computer programs and computer software for artificially creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; providing computer programs and non-downloadable computer software for artificially creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; information technology services, namely developing pretrained neural network weightings, parameters and meta-parameters for large language models for automatically creating, recognizing, translating, processing, understanding, generating and analyzing spoken language, text and language; providing software for the development of pretrained weightings, parameters and meta-parameters of neural networks for large language models for automatically creating, recognizing, translating, processing, understanding, generating and analyzing spoken language, text and language; providing non-downloadable pretrained neural network weightings, parameters and meta-parameters for large language models for automatically creating, recognizing, translating, processing, understanding, generating and analyzing spoken language, text and language (information technology services); developing computer programs and conversations; providing non-downloadable computer software for simulating non-downloadable computer programs and downloadable computer software for simulating conversations; developing artificial intelligence models and artificial intelligence software for creating, recognizing, translating, processing, understanding, generating and analyzing languages and monolingual and multilingual human texts; customizing free open source software; hosting and maintenance of platforms, web applications and websites; hosting and maintaining websites and platforms for third parties for common software development; hosting and maintenance of websites and platforms for virtual collaboration.

Abstract

The present invention is directed to a method for preparing 3-dimensional vascular models comprising the 3-dimensional imaging, printing and embedding of 3-dimensional vasculature and subsequent selective dissolution of the printed and embedded 3-dimensional vasculature in the 3-dimensional material. Furthermore, the present invention relates to the 3-dimensional vascular model prepared by the inventive method as well as to methods for the in vitro practice of a surgical method in an animal or human and a method for a surgical intervention in the vasculature of an animal or human in need thereof.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/30 - Anatomical models

Abstract

The present invention relates to a cell line wherein the endogenous class I and/or class II HLA alleles are inactivated, the cell line further comprising (a) a polynucleotide encoding a first fluorescent marker under control of at least one STAT response element, and (b) an interleukin 2 (IL-2) receptor. The invention further relates to the use of said cell line for the identification of antigenic peptide and/or the identification of alloreactive T cell receptors.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• C07K 14/74 - Major histocompatibility complex [MHC]
• C12N 9/22 - Ribonucleases
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

A method of manufacturing a jointless superconducting multi-coil (1, 1') comprises the steps of providing a superconducting element (2) and winding a first part (2b1) around at least part of a first mandrel (3) so as to form a first pre-coil (4) of a first coil (5), winding at least part around at least part of the first mandrel (3) so as to form the first coil (5), and i) winding a second part (2b2) around at least part of a second mandrel (6) so as to form a second pre-coil (7) of a second coil (8) and winding at least part around at least part of the second mandrel (6) so as to form the second coil (8), or ii) winding a second part (2b2) around at least part of the first mandrel (3) so as to form a second pre-coil (7') of a second coil (8') and winding at least part around at least part of the first mandrel (3) so as to form the second coil (8'). The multi-coil (1, 1') comprises the first coil (5) and the second coil (8, 8') being arranged above one another with respect to a longitudinal direction (Lc, Lc') of the multi-coil (1, 1').

IPC Classes  ?

• H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

Abstract

A material for storing thermal energy comprises or consists of a crosslinked polymer, wherein the crosslinked polymer comprises backbone chains, crosslinking chains, and side chains. The crosslinking chains link the backbone chains to one another. The side chains are attached to one site of the backbone chains. The side chains comprise a phase-change moiety, and wherein the phase-change moiety is configured to change between a first solid state and a second solid state.

IPC Classes  ?

• C09K 5/06 - Materials undergoing a change of physical state when used the change of state being from liquid to solid or vice-versa
• C09K 5/14 - Solid materials, e.g. powdery or granular

Abstract

A granular hydrogel composition, preferably for the treatment of wounds, comprising a mixture of at least a plurality of first hydrogel microspheres, wherein the first hydrogel microspheres are formed of a first hydrogel scaffold material, and wherein the first hydrogel microspheres further comprise at least one growth factor compound, and at least a plurality of second hydrogel microspheres, wherein the second hydrogel microspheres are formed of a second hydrogel scaffold material, and wherein the second hydrogel microspheres further comprise at least a capturing compound for capturing a proinflammatory compound, wherein the capturing compound is bound to the second hydrogel scaffold material, and optionally a liquid aqueous phase.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

In a method of investigating cell deformations, a sample fluid including cells suspended in a suspending medium is provided. A flow of the sample fluid through a focusing microchannel is established. The suspending medium is a non-Newtonian fluid having viscoelastic properties such that cells that enter the focusing microchannel are focused towards a center of the focusing microchannel due to the viscoelastic properties of the suspending medium, causing the cells to exit the focusing microchannel in single file. Subsequently, the sample fluid that has exited the focusing microchannel is caused to flow through a deformation microchannel arranged downstream of the focusing microchannel to cause a deformation of cells that have exited the focusing microchannel and have entered the deformation microchannel, the deformation being caused by a flow pattern created by interaction of the fluid flow with the deformation microchannel.

IPC Classes  ?

• G01N 15/1404 - Handling flow, e.g. hydrodynamic focusing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1433 - Signal processing using image recognition

Abstract

The present disclosure relates to genetically modified plants including a modified POTASSIUM TRANSPORTER 2 (AKT2) protein or an overexpressed AKT2 protein. The present disclosure further relates to methods of producing genetically modified plants including the modified AKT2 protein or the overexpressed AKT2 protein. In addition, the present disclosure relates to genetically modified plants with improved photosynthesis, higher rate of CO2 fixation and/or electron transport rate, improved yield under different growing conditions, and improved storage root or tuber growth.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present disclosure relates to genetically modified plants including a modified POTASSIUM TRANSPORTER 2 (AKT2) protein or an overexpressed AKT2 protein. The present disclosure further relates to methods of producing genetically modified plants including the modified AKT2 protein or the overexpressed AKT2 protein. In addition, the present disclosure relates to genetically modified plants with improved phloem transport, improved photosynthesis, higher rate of CO2 fixation and/or electron transport rate, increased yield under different growing conditions, and increased storage root or tuber growth.

IPC Classes  ?

• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

An arrangement (1) for inserting an implant device (2) into biological tissue (4) comprises at least one implant device (2), and at least one insertion device (3). The insertion device (3) is configured to penetrate biological tissue (4). The implant device (2) and the insertion device (3) are configured to couple to one another via an implant-insertion coupling. The implant device (2), when being coupled to the insertion device (3) via the implant-insertion coupling, is insertable into the biological tissue (4) via the insertion device (3). The implant device (2) comprises at least one bundle (5) of fibers (6, 6a, …), and wherein the fibers (6, 6a, …) are coupled to one another via a fiber-fiber coupling, the implant-insertion coupling being different from the fiber-fiber coupling.

IPC Classes  ?

• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/293 - Invasive
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/372 - Arrangements in connection with the implantation of stimulators
• A61B 5/262 - Needle electrodes
• A61N 1/00 - ElectrotherapyCircuits therefor

Abstract

A motion generation system includes a tracking model, executed by a processor, configured to track at least one kinematic reference motion of a robotic device; a reward surrogate model, executed by the processor, that evaluates a performance of the tracking model with respect to the at least one kinematic reference motion and estimates at least one reward for the tracking model based on the performance; and a generative model, executed by the processor, configured to generate a motion for the robotic device based on a contextual input and the estimated at least one reward, wherein the generative model is trained with a pre-training operation and a refinement operation separate from the pre-training operation.

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

The present invention relates to a method for the determination of cleavage sites in genomic DNA caused by exposure to one or more site directed nucleases ("SDN") directed against one or more genomic target sequences (Fig. 7).

IPC Classes  ?

• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

A steerable device for use inside of a mammalian body, including an elongated element and a flexible device tip which includes a tubular section and a plurality of permanent magnetic elements disposed in the tubular section. Each magnetic element has an axial bore and the axial bores form an axial conduit in which a core wire extends. The axial bore extends from a first to a second axial end of the magnetic element opposed to the first axial end. First axial ends and second axial ends have a bevel allowing movement of the magnetic elements against one another, wherein the bevel of axial ends of adjacent magnetic elements is rounded with a different radius or flat with a different angle to the longitudinal axis to control bending of the device tip.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

222 concentration changes, wherein the sensor comprises: two electrodes; and a sensing composite arranged between the two electrodes; wherein the sensing composite comprises: one or more carbon-based nanostructures having an outer surface; one or more metal-oxides functionalized to the outer surface of the one or more carbon-based nanostructures; and one or more photosensitizer capable of harvesting visible light, thereby inducing a photoconductance change in the underlying metal-oxide functionalized to the one or more carbon-based nanostructure, wherein said photosensitizers are functionalized to the outer surface of the one or more carbon-based nanostructures and/or the one or more metal-oxides.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid

Abstract

The invention relates to a bacterial cell comprising a Cas1 RT fusion protein, a Cas2 protein and a CRISPR direct repeat (DR) sequence, wherein an RNA polymerase promoter in addition to the leader sequence is associated with the DR sequence. The invention further relates to a composition comprising two bacterial cell populations, each comprising a Cas1 RT fusion protein and Cas2 protein. The two cell types contain different versions of a CRISPR direct repeat (DR) sequence. The invention further relates to methods for analysis of transcription recording events of bacteria having passed through a subject's intestine, to assign a probability to the subject having a condition, such as malnutrition or inflammation of the intestine.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/22 - Ribonucleases
• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• C12R 1/19 - Escherichia coli

Abstract

A CRISPR-based genome editing is disclosed. More specifically, nucleic acids, compositions and kits for editing a human HBD gene and their use in the treatment of haemoglobinopathies are disclosed. Methods of making thereof and methods of editing a human HBD gene are also disclosed. The composition and/or kit contains (a) a first component selected from a guide RNA (gRNA) or a DNA polynucleotide encoding the gRNA, (b) a second component selected from a DNA donor template or a vector containing the DNA donor template, and (c) a third component containing a Cas9 polypeptide or a variant thereof or a nucleic acid encoding a Cas9 polypeptide or a variant thereof.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

The present invention relates to a hydrogel that can be used to prevent or treat endometriosis and as mechanical contraception. Said hydrogel comprises a crosslinked network of at least a) a first monomer unit selected from the group consisting of acrylamide-2-methylpropanesulfonic acid (AMPS), acrylic acid, sodium acrylate, polyethylene glycol acrylate, (acrylamidopropyl)trimethylammonium chloride, methacrylic acid, 2-(dimethylamino)ethyl acrylate, 2-aminoethyl acrylate hydrochloride and 2-acryloxyethyltrimethylammonium chloride or a mixture thereof, b) a second monomer unit selected from the group consisting of N-2-hydroxyethyl acrylamide (NHEA), N-2-hydroxypropyl acrylamide (NHPA), acrylamide, N-isopropylacrylamide (NIPAm), hydroxyethyl methacrylate (HEMA), hydroxyethyl acrylate (HEA), methyl acrylate, butyl acrylate, ethyl hexyl acrylate, methacrylamide, and ethyl hexyl (meth)acrylate or a mixture thereof, c) at least one crosslinker with dual functionality, having at least two crosslinking groups and at least one degradable moiety selected from the group consisting of a photo-labile group, a disulfide bond and a diselenide bond.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide

Abstract

Described is an exoskeleton device for assisted movement of a body member. The exoskeleton is for assisted movement of a member comprising a plurality of joints. The exoskeleton includes a first rigid section and a second rigid section positioned at respectively opposite ends of the member and an intermediate rigid section between the first and second rigid sections and positioned between the joints in the member. The exoskeleton also includes a repeating M structure comprising a plurality of length segments, each length segment extending between a respective pair of said rigid sections, and a drive spring extending at least from the first rigid section to the second rigid section, along an external region of the repeating M-structure, the drive spring between extendable and retractable to actuate the exoskeleton. A stiffness of each length segment is selected based on an amount of force to be applied to the member.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• A61F 2/50 - Prostheses not implantable in the body
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

A filter assembly (1) for filtering a sample from a fluid (F) comprises a filter holder (4), a filter membrane (5), and a filter housing (6). The filter holder (4) is at least partially received in the filter housing (6), and the filter membrane (5) is attached to the filter holder (4) and is configured to filter a sample from a fluid (F) flowing from an inlet port (2) to an outlet port (3) through the filter membrane (5). The filter holder (4) is removably attached to the filter housing (6) such, that the filter holder (4) together with the filter membrane (5) is removable from the filter housing (6) and is insertable into a storage assembly (100) comprising a storage housing (20).

IPC Classes  ?

• G01N 1/14 - Suction devices, e.g. pumpsEjector devices
• B01D 29/15 - Supported filter elements arranged for inward flow filtration
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
• G01N 1/40 - Concentrating samples

Abstract

The present invention relates to a heterobifunctional linker and its use in the preparation of a vaccine.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

îîiîνν, the phase angle of the virtual internal voltage (formula (IV)) is controlled to match with the phase angle reference of the voltage reference (formula (I)) and the magnitude of the virtual internal voltage (formula (IV)) is adaptively changed depending on overcurrent conditions.

IPC Classes  ?

• H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
• H02M 1/00 - Details of apparatus for conversion
• H02M 1/32 - Means for protecting converters other than by automatic disconnection
• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers

Abstract

Catalyst assisted chemical etching of semiconductor substrate can achieve extreme aspect ratio (better than 1000:1), reproducibility and controlled etching quality for submicron feature size in the direction perpendicular to the substrate. The current patterning methods of the catalyst layer suffer of carbon contamination that affects the etching quality and limits the high-resolution pattern transfer in the semiconductor substrate for high aspect ratio etching. The present method allows to use semiconductor standard manufacturing processes to realize carbon-free pattern of catalyst layer by a physical separation with an interlayer material between the catalyst and the polymeric resist used in common lithographic methods. The present method allows to realize controlled predefined nanostructures with high resolution, high fidelity and high throughput yield during the catalyst assisted chemical etching of silicon for X-ray optics nanofabrication.

IPC Classes  ?

• H01L 21/308 - Chemical or electrical treatment, e.g. electrolytic etching using masks

Abstract

A method for designing a custom-made intra-oral appliance includes obtaining a virtual 3D reconstruction of an oral cavity, identifying an appliance region, obtaining a 3D appliance mesh from the appliance region, and processing the 3D appliance mesh for obtaining a volumetric appliance mesh. A method for obtaining a virtual 3D reconstruction of an oral cavity, the virtual 3D reconstruction being suitable for use in designing custom-made intra-oral appliances, and a method for designing an intra-oral appliance. The method for obtaining a virtual 3D reconstruction of an oral cavity includes obtaining at least one 2D image of an oral cavity, wherein the at least one image is acquired by a consumer electronics product, transforming the obtained at least one 2D image into an initial virtual 3D reconstruction of the oral cavity, and transferring information included in a further virtual 3D reconstruction to the initial virtual 3D reconstruction.

IPC Classes  ?

• A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
• A61C 7/08 - Mouthpiece-type retainers
• G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD

Abstract

The present disclosure relates to a beamlet diffraction fringe generation method for attenuation, differential phase-contrast and dark-field imaging. By generating a fringe through structured diffraction beamlet arrays (Fig. 10) from structured diffraction beamlet array optics (10), an intensity variation is induced by superposition. As this effect does not rely on Talbot-carpet orders, it provides a tool for arbitrary fringe geometry and size generation at any distance.

IPC Classes  ?

• G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers

Abstract

The present invention relates to a highly efficient process for the photo-initiated depolymerization of vinyl polymers in the presence of at least one chlorine-containing reagent, preferably at elevated temperatures. The invention further relates to the recycling of vinyl polymers comprising the process according to the invention as well as the use of chlorine-containing reagents for the depolymerization of vinyl polymers.

IPC Classes  ?

• C08J 11/20 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with hydrocarbons or halogenated hydrocarbons

Abstract

The present invention relates to a method for defattening a steatotic liver ex vivo, the method comprising perfusing a steatotic liver graft in a perfusion step using a perfusate comprising a PI4KB inhibitor as specified or a pharmaceutically acceptable salt or solvate thereof.

IPC Classes  ?

• A01N 1/126 - Physiologically active agents, e.g. antioxidants or nutrients
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

The present invention relates to a method for defattening a steatotic liver ex vivo, the method comprising perfusing a steatotic liver graft in a perfusion step using a perfusate comprising a PI4KB inhibitor as specified or a pharmaceutically acceptable salt or solvate thereof.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A01N 1/126 - Physiologically active agents, e.g. antioxidants or nutrients

Abstract

The present invention relates to a medical device (100) for use as a ureteral stent, a biliary stent or a urinary catheter in a human or animal body. The medical device (100) comprises a hollow device body (101) having at least one body lumen (102), an inner body surface (105) and an outer body surface (106), wherein the inner body surface (105) delimits the at least one body lumen (102). The medical device (100) further comprises at least one array (110) of microstructures (111) located on the inner body surface (105) and/or the outer body surface (106) and configured to locally increase fluid-induced shear stress acting on the device body (101) in use of the medical device (100) in response to applying an acoustic field to the medical device (100). The invention further relates to a medical system comprising such as a medical device and an activation device configured to be positioned externally of a human or animal body, wherein the activation device comprises at least one sound transducer configured to generate an acoustic field for application from externally of the human or animal body to the medical device. The invention further relates to as to a method of acoustically activating such a medical device during use in a human or animal body, in particular for cleaning purposes and/or mass transport.

IPC Classes  ?

• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts

Abstract

A laser distance ranging method includes splitting two combs of dual comb radiation into a signal radiation portion and a local oscillator radiation portion. The signal radiation portions are, after separation, combined into a combined signal radiation and directed onto an object, the distance to which is to be measured. The signal thrown back from the object is split into a first and second signal portions. The first signal portion is superimposed with the second local oscillator radiation portion to generate a first measurement signal, and the second signal portion is superimposed with the first local oscillator radiation portion to generate a second measurement signal. The distance to the object is determined from the first and second measurement signals, and from reference signals obtained by the partial reflection, wherein the Vernier effect can be used to extend ambiguity by comparison of the first and second measurement signals.

IPC Classes  ?

• G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G01S 7/484 - Transmitters
• G01S 7/4863 - Detector arrays, e.g. charge-transfer gates
• G01S 7/499 - Details of systems according to groups , , of systems according to group using polarisation effects

Abstract

The invention relates to a device designed to measure and/or influence a property of a body fluid, in particular cerebrospinal fluid, provided in a fluidics module of the device. The device comprises the fluidic module, a reusable base part for receiving the fluidic module, a connecting tube or a tube coupling designed to connect the device to a body fluid source, in particular a patient, such that the body fluid can be guided through the connecting tube or the tube coupling into the fluidic module of the device, and a microfluidic chip arranged on or in the fluidic module and designed to influence the property of the body fluid.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• B01D 11/04 - Solvent extraction of solutions which are liquid
• A61B 5/15 - Devices for taking samples of blood
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

The invention relates to a traveling wave parametric amplifier (TWPA) for amplifying a target signal. The TWPA comprises a nonlinear transmission line (T1, T2) for receiving and propagating the target signal. The TWPA also comprises a plurality of coupling elements (DC1, DC2), wherein the plurality of coupling elements (DC1, DC2) are arranged at a distance from one another along the nonlinear transmission line (T1, T2). Each coupling element of the plurality of coupling elements (DC1, DC2) is configured to couple a pump signal portion from a pump feed line (D1) into the nonlinear transmission line (T1, T2), wherein the coupled-in pump signal portions form a total pump signal co-propagating in the nonlinear transmission line (T1, T2) in the same direction as the target signal for amplifying the target signal.

IPC Classes  ?

• H03F 7/00 - Parametric amplifiers
• H03F 19/00 - Amplifiers using superconductivity effects

Abstract

A process for screening a plasmid library encoding for peptides for one or more peptides that functionally activate a G protein-coupled receptor in a cell, by contacting the peptides with a cell expressing a G protein-coupled receptor, which functions as a sensor, and isolating the cells that functionally activate a G protein-coupled receptor to determine the sequence encoding the peptides.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12P 21/00 - Preparation of peptides or proteins
• C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof

Abstract

A ring cavity laser (10) based on a semiconductor gain medium providing a lasing transition between quantised energy bands. The laser's ring cavity (12) possesses a plurality of modes, at least one of which having a frequency around which sufficient gain can be generated to cause lasing action. An electrical driver circuit applies an injection current to the semiconductor gain medium to cause population inversion and lasing action. A modulator (18) provides phase modulation within the cavity optical path at a modulation frequency near- resonant with an integer multiple or fraction of one of the mode frequencies. The phase modulation causes the laser to output a stable optical frequency comb which is established by random quantum walk in a photonic lattice created by said mode and its neighbouring resonator modes. A random quantum walk arises when these modes are coupled by the phase modulation.

IPC Classes  ?

• H01S 5/065 - Mode lockingMode suppressionMode selection
• H01S 5/062 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes
• H01S 5/10 - Construction or shape of the optical resonator
• H01S 5/14 - External cavity lasers
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 3/081 - Construction or shape of optical resonators or components thereof comprising three or more reflectors
• H01S 3/083 - Ring lasers
• H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers

Abstract

A microfluidic device comprises a flow channel (10) defining a flow direction (F), an array (20) of pillars (23) arranged in the flow channel (10), the array (20) comprising a supporting row (21) of pillars, the pillars of the supporting row (21) being separated by supporting row gaps (24) having a supporting row gap width (), and a membrane (30) comprising colloidal particles which are packed against the supporting row. At least some of the colloidal particles are larger than the supporting row gap width. Also disclosed is a method of manufacturing the device and a method of detecting bioburden using the device.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The novel invention is based, at least in part. on the surprising finding that the combination of bacterial strains comprising P. freudenreichii JS27 and B. longum subsp. infantis, particularly B. longum subsp. infantis TPY12-1 can be used in medicine and/or as a food supplement when grown simultaneously. As such and as shown in the description and appended examples, growth and viability of bacterial strains possessing synergistic behavior can be enhanced in the human gut and thus can increase bioavailability as compared with alternative combinations of bacteria.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61K 35/745 - Bifidobacteria
• C12N 1/20 - BacteriaCulture media therefor
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The invention relates to a method for assessing corrosion phenomena on at least one metal element (1), wherein an electrode (5) is in electrically conductive connection with an electrolyte volume (4) positioned outside a metal element (1) or a material (3) that is electrolytically conductive or can be made electrolytically conductive and that is at least partially covering the metal element (1), and wherein the electrolyte volume (4) is brought into electrically conductive contact with the metal element (1) or the material (3) via a stream (10) of electrolyte, and wherein an electrochemical measurement indicative of a state of corrosion on the metal element (1) is carried out. The invention further relates to a device (11) and a system (100) for assessing corrosion phenomena on at least one metal element (1).

IPC Classes  ?

• G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light
• G01N 17/02 - Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement

Abstract

A spectrometer assembly (1) for determining spectral information about incoming electromagnetic radiation (F) comprises a radiation conversion element (2) that comprises a non-centrosymmetric material to frequency-double at least a portion of the incoming electromagnetic radiation (F) as the incoming electromagnetic radiation (F) propagates through the radiation conversion element (2). The radiation conversion element (2) exhibits a spatially inhomogeneous structure such that the frequency-doubled electromagnetic radiation (SH) comprises components propagating in a plurality of different directions. The spectrometer assembly further comprises a detection unit (3) which is configured to record a spatial speckle image that is generated by spatial interference of the components of the frequency-doubled electromagnetic radiation (SH) with each other, and a computing unit (4) which is configured to retrieve spectral information about the electromagnetic radiation (F) based on said spatial speckle image.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/28 - Investigating the spectrum
• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01J 3/453 - Interferometric spectrometry by correlation of the amplitudes

Abstract

A transceiver assembly (1) for receiving signals of a body tissue (2) and/or transmitting signals to a body tissue (2) comprises at least one holding device (3) and at least one transceiver device (4). The transceiver device (4) comprises at least one first transceiver- magnetic element (5) and the holding device (3) comprises at least one first holding-magnetic element (6), the first transceiver-magnetic element (5) and the first holding-magnetic element (6) being arranged after one another with respect to a connection direction (C) and being configured to exert a magnetic force to one another. The transceiver device (4) comprises at least one second transceiver-magnetic element (7) and the holding device (3) comprises at least one second holding-magnetic element (8) being arranged after one another with respect to a transverse direction (T) and are configured to exert a magnetic force to one another. The transceiver device (4) is connectable to the holding device (3) via an overall magnetic force exerted by the first and second transceiver-magnetic elements (5; 7) and by the first and second holding-magnetic elements (6; 8).

IPC Classes  ?

• A61B 5/273 - Connection of cords, cables or leads to electrodes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• H01R 13/62 - Means for facilitating engagement or disengagement of coupling parts or for holding them in engagement
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters