Evofem Biosciences, Inc.

United States of America

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2024 1
2023 1
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2020 25
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IPC Class
A61K 31/4164 - 1,3-Diazoles 14
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol 12
C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members 12
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone 11
A61K 9/00 - Medicinal preparations characterised by special physical form 11
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NICE Class
05 - Pharmaceutical, veterinary and sanitary products 21
42 - Scientific, technological and industrial services, research and design 14
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services 9
35 - Advertising and business services 1
36 - Financial, insurance and real estate services 1
Status
Pending 7
Registered / In Force 39

1.

PHEXX

      
Serial Number 98733431
Status Pending
Filing Date 2024-09-04
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment. Providing an interactive web site featuring technology for connecting a network of health care professionals and service providers with patients; Providing an interactive web site featuring technology for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients. Providing on-line information services in the field of health; Providing an interactive website featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive website for relaying information about medical experiences for patient support; Providing an interactive website featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health.

2.

DEUTERATED SECNIDAZOLE FOR USE IN THE TREATMENT OF BACTERIAL VAGINOSIS AND METHODS AND USES THEREOF

      
Application Number 17963942
Status Pending
Filing Date 2022-10-11
First Publication Date 2023-11-02
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Holl, Richard John
  • Nielsen, Kurt
  • Garegnani, James

Abstract

The present invention is related to deuterated secnidazole, a prodrug thereof, a metabolite thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof. The present invention is also related to methods of screening deuterated forms of secnidazole to identify potent and high metabolic lifetime compounds for treating bacterial vaginosis or trichomoniasis.

IPC Classes  ?

  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/4164 - 1,3-Diazoles
  • A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol

3.

Deuterated secnidazole for use in the treatment of bacterial vaginosis and methods and uses thereof

      
Application Number 17681634
Grant Number 12172969
Status In Force
Filing Date 2022-02-25
First Publication Date 2022-08-18
Grant Date 2024-12-24
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Holl, Richard John
  • Nielsen, Kurt
  • Garegnani, James

Abstract

The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.

IPC Classes  ?

  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/4164 - 1,3-Diazoles
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

4.

METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING TRICHOMONIASIS AND USES THEREOF

      
Application Number 17028838
Status Pending
Filing Date 2020-09-22
First Publication Date 2022-03-24
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.
  • Holl, Richard
  • Kaufman, Gregory

Abstract

Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/69 - Boron compounds
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
  • A61K 31/702 - Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

5.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 17335016
Grant Number 11684607
Status In Force
Filing Date 2021-05-31
First Publication Date 2021-09-16
Grant Date 2023-06-27
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

6.

COALITION FOR HORMONE-FREE CONTRACEPTIVE COVERAGE

      
Serial Number 97024067
Status Registered
Filing Date 2021-09-13
Registration Date 2023-03-07
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 35 - Advertising and business services
  • 36 - Financial, insurance and real estate services

Goods & Services

Promoting public awareness of health and wellness issues relating to medical insurance coverage Insurance information services, namely, providing health and wellness awareness information via recommended resources mainly in the field of medical insurance coverage issues

7.

Secnidazole for use in the treatment of sexually transmitted infection

      
Application Number 17314833
Grant Number 11602522
Status In Force
Filing Date 2021-05-07
First Publication Date 2021-08-26
Grant Date 2023-03-14
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.
  • Holl, Richard

Abstract

Method of treating sexually transmitted infection in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above. Pharmaceutical compositions and uses thereof are included herein.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

8.

PHEXXI CONCIERGE EXPERIENCE

      
Application Number 018340045
Status Registered
Filing Date 2020-11-19
Registration Date 2021-07-15
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing an interactive web site containing technology for connecting a network of health care professionals and service providers with patients; Providing an interactive web site containing technology for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients. Providing on-line information services in the field of health; Providing an interactive web site containing healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing an interactive web site containing healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health.

9.

PHEXXI

      
Application Number 018340049
Status Registered
Filing Date 2020-11-19
Registration Date 2021-06-18
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing on-line information services in the field of health; Providing an interactive web site for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing an interactive web site for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health.

10.

phexxi

      
Application Number 018333789
Status Registered
Filing Date 2020-11-06
Registration Date 2021-03-18
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal Environment.

11.

Secnidazole for use in the treatment of trichomoniasis

      
Application Number 16901739
Grant Number 11000508
Status In Force
Filing Date 2020-06-15
First Publication Date 2020-10-01
Grant Date 2021-05-11
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.
  • Holl, Richard

Abstract

Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

12.

Secnidazole for use in the treatment of trichomoniasis

      
Application Number 16890526
Grant Number 11324721
Status In Force
Filing Date 2020-06-02
First Publication Date 2020-09-17
Grant Date 2022-05-10
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to secnidazole formulations and the use of a secnidazole formulation for the treatment of trichomoniasis in a subject in need thereof.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

13.

XX

      
Serial Number 90160383
Status Registered
Filing Date 2020-09-04
Registration Date 2021-09-21
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment

14.

XX

      
Serial Number 90160391
Status Registered
Filing Date 2020-09-04
Registration Date 2021-09-21
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment

15.

EVOFEM BIOSCIENCES

      
Serial Number 90045858
Status Registered
Filing Date 2020-07-10
Registration Date 2021-08-31
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

16.

EVOFEM

      
Serial Number 90045871
Status Registered
Filing Date 2020-07-10
Registration Date 2021-08-31
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

17.

EVOFEM BIOSCIENCES

      
Serial Number 90045876
Status Registered
Filing Date 2020-07-10
Registration Date 2021-08-31
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

18.

EVOFEM

      
Application Number 018266337
Status Registered
Filing Date 2020-07-03
Registration Date 2020-11-10
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment. Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare.

19.

EVOFEM BIOSCIENCES

      
Application Number 018266340
Status Registered
Filing Date 2020-07-03
Registration Date 2020-11-10
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment. Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare.

20.

EVOFEM BIOSCIENCES

      
Application Number 018266344
Status Registered
Filing Date 2020-07-03
Registration Date 2020-11-10
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment. Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare.

21.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 16817246
Grant Number 11000507
Status In Force
Filing Date 2020-03-12
First Publication Date 2020-07-02
Grant Date 2021-05-11
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.
  • Holl, Richard

Abstract

Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

22.

EVOFEM

      
Application Number 203709000
Status Pending
Filing Date 2020-06-30
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

(1) Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment (1) Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare

23.

EVOFEM BIOSCIENCES

      
Application Number 203709200
Status Pending
Filing Date 2020-06-30
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

(1) Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment (1) Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare

24.

EVOFEM BIOSCIENCES

      
Application Number 203709100
Status Pending
Filing Date 2020-06-30
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

(1) Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment (1) Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare

25.

PHEXXI

      
Serial Number 88927879
Status Registered
Filing Date 2020-05-21
Registration Date 2023-05-16
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment

26.

PHEXXI

      
Serial Number 88927889
Status Registered
Filing Date 2020-05-21
Registration Date 2021-06-15
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing an interactive web site featuring technology for connecting a network of health care professionals and service providers with patients; Providing an interactive web site featuring technology for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing health information; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

27.

PHEXXI CONCIERGE EXPERIENCE

      
Serial Number 88925395
Status Registered
Filing Date 2020-05-20
Registration Date 2021-03-16
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing an interactive web site featuring technology for connecting a network of health care professionals and service providers with patients; Providing an interactive web site featuring technology for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing health information; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

28.

PHEXXI

      
Serial Number 88910057
Status Registered
Filing Date 2020-05-11
Registration Date 2021-02-23
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing an interactive web site featuring technology for connecting a network of health care professionals and service providers with patients; Providing an interactive web site featuring technology for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients Providing on-line information services in the field of health; Providing an interactive web site featuring healthcare information for connecting a network of health care professionals and service providers with patients; Providing health information; Providing internet-based medical information for users about medical products, issues, and procedures; Providing an interactive web site for relaying information about medical experiences for patient support; Providing health information; Providing an interactive web site featuring healthcare information for facilitating the collection of survey data and information to connect a network of health care professionals and service providers with patients; Providing health information in the field of women's health

29.

BEYOND HORMONES

      
Application Number 201901400
Status Pending
Filing Date 2020-03-23
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

(1) Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment

30.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 16586372
Grant Number 11020377
Status In Force
Filing Date 2019-09-27
First Publication Date 2020-02-06
Grant Date 2021-06-01
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

31.

PHEXXI

      
Application Number 018189548
Status Registered
Filing Date 2020-01-30
Registration Date 2020-06-05
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment.

32.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 16586339
Grant Number 10857133
Status In Force
Filing Date 2019-09-27
First Publication Date 2020-01-23
Grant Date 2020-12-08
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

33.

PHEXXI

      
Serial Number 88596085
Status Registered
Filing Date 2019-08-28
Registration Date 2020-11-17
Owner Evofem Biosciences, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for spermatozoa; pharmaceutical preparations, namely, microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment

34.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 16403176
Grant Number 10849884
Status In Force
Filing Date 2019-05-03
First Publication Date 2019-08-22
Grant Date 2020-12-01
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

35.

MVP-R

      
Application Number 018060177
Status Registered
Filing Date 2019-05-03
Registration Date 2019-09-27
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Personal lubricant; personal sexual lubricants; microbicidal that creates an inhospitable environment for spermatozoa; microbicidal that creates an inhospitable environment for viral and bacterial pathogens; pharmaceutical acid-buffering gel with bio adhesive properties designed to maintain an optimal environment.

36.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 16049032
Grant Number 10682338
Status In Force
Filing Date 2018-07-30
First Publication Date 2018-11-22
Grant Date 2020-06-16
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.
  • Holl, Richard

Abstract

Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules

37.

METHOD OF TREATMENT AND PREVENTION OF BACTERIAL VAGINOSIS

      
Application Number US2017054943
Publication Number 2018/067568
Status In Force
Filing Date 2017-10-03
Publication Date 2018-04-12
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor Friend, David R.

Abstract

Described herein are methods of reducing the risk of recurrence of bacterial vaginosis by intravaginal administration of compositions comprising L-lactic acid, polymer thickener, and preservative.

IPC Classes  ?

  • A61K 31/19 - Carboxylic acids, e.g. valproic acid
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

38.

COMBINATION GEL FOR SEXUALLY TRANSMITTED INFECTIONS

      
Application Number US2017050960
Publication Number 2018/049326
Status In Force
Filing Date 2017-09-11
Publication Date 2018-03-15
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor Friend, David R.

Abstract

Described herein are compositions comprising a combination of L-lactic acid and carrageenan and methods for treating or preventing HPV or other sexually transmitted infections by administering the composition.

IPC Classes  ?

  • A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
  • A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof

39.

Secnidazole formulations and use in treating bacterial vaginosis

      
Application Number 15170572
Grant Number 11253501
Status In Force
Filing Date 2016-06-01
First Publication Date 2016-12-01
Grant Date 2022-02-22
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Palling, David
  • Vladyka, Ronald S.
  • Amprey, Joseph

Abstract

Embodiments described herein are directed to novel pharmaceutical compositions comprising a plurality of microgranules comprising nitroimidazole compounds, and uses of these pharmaceutical compositions in the treatment of bacterial vaginosis.

IPC Classes  ?

  • A61K 31/4164 - 1,3-Diazoles
  • A61K 9/50 - Microcapsules
  • A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

40.

EVOFEM BIOSCIENCES

      
Serial Number 87114299
Status Registered
Filing Date 2016-07-24
Registration Date 2018-12-25
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare Pharmaceutical products and preparations directed to women's healthcare, namely, contraceptive foams, sponges, pills, creams, preparations; Pharmaceutical preparations for the treatment and prevention of disorders of the reproductive system; pharmaceutical preparations for vaginal lubrication; vaginal microbiocidal spermicidal gel; personal lubricant; menstrual fluid collection devices, namely, menstrual underwear

41.

EVOFEM

      
Serial Number 87099418
Status Registered
Filing Date 2016-07-11
Registration Date 2019-03-12
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Pharmaceutical products and preparations directed to women's healthcare, namely, contraceptive foams, sponges, preparations, gels; Pharmaceutical preparations for the treatment and prevention of disorders of the reproductive system; Pharmaceutical preparations for vaginal lubrication; vaginal microbiocidal spermicidal gel; personal lubricant; menstrual fluid collection devices, namely, menstrual underwear research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare

42.

EVOFEM BIOSCIENCES

      
Serial Number 87099394
Status Registered
Filing Date 2016-07-11
Registration Date 2018-12-04
Owner Evofem Biosciences, Inc. ()
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Pharmaceutical products and preparations directed to women's healthcare, namely, contraceptive foams, gels, lubricants, preparations; Pharmaceutical preparations for the treatment and prevention of disorders of the reproductive system; Pharmaceutical preparations for vaginal lubrication; vaginal microbiocidal spermicidal gel; personal lubricant; menstrual fluid collection devices, namely, menstrual underwear research and development of medical, pharmaceutical, therapeutic and technological solutions for women's healthcare

43.

Secnidazole for use in the treatment of bacterial vaginosis

      
Application Number 14846505
Grant Number 10335390
Status In Force
Filing Date 2015-09-04
First Publication Date 2016-03-10
Grant Date 2019-07-02
Owner EVOFEM BIOSCIENCES, INC. (USA)
Inventor
  • Pentikis, Helen S.
  • Palling, David
  • Braun, Carol J.

Abstract

Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61K 31/4164 - 1,3-Diazoles
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 233/94 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/50 - Microcapsules
  • A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
  • A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone

44.

SOLOSEC

      
Serial Number 86696432
Status Registered
Filing Date 2015-07-17
Registration Date 2018-06-19
Owner EVOFEM BIOSCIENCES, INC. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical and biological preparations used in the treatment of women's health infections

45.

AMPHORA

      
Application Number 013496039
Status Registered
Filing Date 2014-11-25
Registration Date 2015-03-20
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for vaginal lubrication; vaginal microbiocidal spermicidal gel; personal lubricant.

46.

AMPHORA

      
Application Number 986073
Status Registered
Filing Date 2008-11-20
Registration Date 2008-11-20
Owner Evofem Biosciences, Inc. (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for vaginal lubrication; vaginal microbiocidal spermicidal gel; personal lubricant.