The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).
According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus further comprises a sonotrode (6) having a length Ls that is 150-220% of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98% of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence.
The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence.
The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments.
The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus further comprises a sonotrode (6) having a length Ls that is 150-220% of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98% of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material.
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material.
A further object of the invention is to fabricate drug-containing T-intrauterine systems (IUS) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %:of Indomethacin.
A61K 9/00 - Medicinal preparations characterised by special physical form
B33Y 80/00 - Products made by additive manufacturing
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
9.
Inserter for an intrauterine system with a locking part
Disclosed is an inserter for an intrauterine system, comprising including a handle body, a measurement tube, a plunger, a flange, a finger holder, and a mechanism for reversibly locking removal thread of the intrauterine system. A proximal end of the measurement tube is movably attached to a distal end of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Contraceptive pharmaceutical preparations contained in and released from a sub dermal implant An unfilled contraceptive implant to be inserted under the skin for releasing hormones
According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus 5 further comprises a sonotrode (6) having a length Ls that is 150-220 % of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98 % of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus 5 further comprises a sonotrode (6) having a length Ls that is 150-220 % of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98 % of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5). The inserter further includes a lock that reversibly locks the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, the lock being controllable by the slider (5) and/or the insertion tube (6).
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5). The inserter further includes a lock that reversibly locks locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, the lock being controllable by the slider (5) and/or the insertion tube (6).
The present invention relates to ultrasonically detectable intrauterine systems and to a method for enhancing ultra-sound detection of these systems. An intrauterine sys-tem having an inert metal coating on at least part of the body of the intrauterine system or at least one inert metal clip, pin, ring or sleeve fixedly positioned on the body of the intrauterine system is described.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence.
The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments.
The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
An inserter for an intrauterine system can include a handle having an opening, a slider arranged in the opening, a plunger attached to the handle, an insertion tube attached to the slider and arranged around the plunger, and a lock adapted to reversibly lock at least one removal string of the intrauterine system. The lock can include a main part with an opening, the main part being rotatably mounted on a shaft or axle, an extension of the main part, and a counterpart. The removal string passes through the opening of the main part and is immobilized between the main part and the counterpart when the lock is in a locking position. The slider is configured to press against the extension of the main part and turn the main part around the shaft or axle to release the removal string as the slider is moved backwards.
The present invention relates to a method for marking a removal thread (4, 8, 12, 14, 16) of an intrauterine system (3), the removal thread having a length L, the method comprising using laser marking. The invention also relates to use of laser marking for marking a removal thread of an intrauterine system, as well as to the intrauterine system itself.
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
Disclosed is an intrauterine system (100, 500, 700, 800, 900) comprising a frame (102, 502, 702, 802, 902, 1020), at least one sleeve (104, 508, 602, 704, 706, 804, 806, 808, 1016) and at least one capsule (106, 504, 506, 708, 710, 810, 812, 814, 904, 906, 1018). The frame has a first 5 end (108, 512, 714, 818, 914) and a second end (110, 516, 718, 822, 918). The sleeve having a first end (522, 604, 724, 728, 830, 834, 1022) and a second end (122, 524, 606, 726, 730, 832, 1024) is arranged to movably surround a part (1028) of the frame. The capsule comprises a pharmaceutically active agent. The capsule having a first end (126, 924, 10 928) and a second end (128, 926, 930) is arranged to surround the sleeve. Furthermore, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
Disclosed is an inserter (1100, 1400, 1500) for an intrauterine system (1402, 1522), comprising a handle (1102, 1418, 1502), an inner tube (1122, 1300, 1438, 1506), a measurement tube (1110, 1406, 1504), a plunger (1128, 1448, 1540), a flange (1118, 1404, 1530), a tip cover (1116, 1422, 1520), and means (1120, 1420, 1514) for moving the plunger. A proximal end (1112, 1516) of the measurement tube is movably connected to a distal end (1106, 1426, 1510) of the handle. The measurement tube is movably arranged to surround the inner tube. The plunger is movably arranged inside the inner tube and has a proximal end (1130, 1538) and a distal end (1132), and its distal end is configured to cooperate with the intrauterine system. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
The present invention relates to an inserter for an intrauterine system, comprising a handle (1,11), an insertion tube (4) having a longitudinal direction and connected to the handle, and a plunger (3) arranged inside the insertion tube. The inserter also comprises a force sensor (6, 5 9) arranged between the insertion tube and the handle. The insertion tube is partially arranged inside the force sensor in such a manner that when force is exerted on the insertion tube along its longitudinal direction, the insertion tube is arranged to move with respect to the force sensor.
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical publications in the nature of brochures, magazines and booklets in the field of gynecology Conducting scientific studies in the field of gynecology Medical services in the field of gynecology
Disclosed is a sound applicator (100, 1000, 1100, 1200, 1300, 1400) comprising a handle (102, 1002, 1102, 1202, 1302, 1402) and a sound tube (116, 602, 1004, 1104, 1204, 1304, 1404). The handle has a proximal end (104, 1210) and a distal end (106, 1212), and comprises a container (108, 1020, 1312, 1406) for an anaesthetic product (814) and a means (110, 1018, 1106, 1206) for discharging the anaesthetic product from the container. The sound tube has a proximal end (118) and a distal end (120), having length L. The proximal end of the sound tube is attachable to the distal end of the handle for allowing the anaesthetic product to enter the sound tube. The sound tube comprises openings (122) arranged along a distance D from its distal end. The present disclosure also provides a kit for a sound applicator.
the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterised in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
The present invention relates to a tenaculum comprising a suction head (1) and a handle part (3) connected to each other by a suction tube (2), the handle part comprising a vacuum pump. The vacuum pump comprises a vacuum tank (12) comprising a first opening at its first end and a second opening at its second end, wherein the suction tube is connected to the first opening; a spring (16); means for compressing the spring (4); and a piston. The piston comprises a piston head (13) moveably arranged within the vacuum tank; an axle (15) having a first end and a second end, its first end being connected to the piston head (13) and its second end being connected to the means for compressing the spring (4); and a pressure seal (14) arranged on the piston head to isolate a vacuum space of the vacuum tank from the second opening. The spring (16) is arranged to move the piston head (13).
A61B 17/42 - Gynaecological or obstetrical instruments or methods
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61B 17/30 - Surgical pincettes, i.e. surgical tweezers
The present invention relates to an inserter for an intrauterine system, comprising a handle (1,11), an insertion tube (4) having a longitudinal direction and connected to the handle, and a plunger (3) arranged inside the insertion tube. The inserter also comprises a force sensor (6, 5 9) arranged between the insertion tube and the handle. The insertion tube is partially arranged inside the force sensor in such a manner that when force is exerted on the insertion tube along its longitudinal direction, the insertion tube is arranged to move with respect to the force sensor.
The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of δ-ΙΟΟμιΐη; the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
The present invention relates to an inserter for an intrauterine system, comprising a handle (1,11), an insertion tube (4) having a longitudinal direction and connected to the handle, and a plunger (3) arranged inside the insertion tube. The inserter also comprises a force sensor (6, 5 9) arranged between the insertion tube and the handle. The insertion tube is partially arranged inside the force sensor in such a manner that when force is exerted on the insertion tube along its longitudinal direction, the insertion tube is arranged to move with respect to the force sensor.
The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of d-???µ???; the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
46.
Method for manufacturing a drug delivery device and a drug delivery device manufactured according to the method
The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
A61K 31/00 - Medicinal preparations containing organic active ingredients
47.
INTRAVAGINAL DRUG DELIVERY SYSTEM, METHOD FOR MANUFACTURING SUCH SYSTEM AND ITS USE IN GYNECOLOGICAL THERAPIES AND CONTRACEPTION
The invention relates to an intravaginal ring consisting of an inert carrier material (A) embedding at least on drug containing insert, wherein the insert(s) are made of a biocompatible polymer material (B) which is enclosed with a cylinder wall (sleeve) made of an inert material impermeable to the drag to reduce the amount of unused drag substance at the end of the wearing period and thus reducing the environmental burden when the IVR is disposed.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/569 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone substituted in position 17 alpha, e.g. ethisterone
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end and a second end and at least one cover slot (35) along its longitudinal direction; a slider (37) movably arranged inside the cover, having a first end and a second end; sliding means (36) movably arranged in the cover slot and attached to the slider, for moving the slider; a needle (32) having a first end and a second end, attached to the slider; and a plunger (34) arranged inside the cover and partially inside the slider at the second end of the slider, and partially inside the needle; wherein the plunger is arranged to move together with the slider when the slider is moved in a first direction, and the plunger is arranged to remain stationary when the slider is moved in a second direction opposite the first direction.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end and a second end; a slider (35) movably arranged inside the cover, having a first end and a second end; sliding means (36) movably arranged on the cover and attached to the slider, for moving the slider; a needle (32) having a first end and a second end, arranged to move within the slider; and a plunger (38) arranged inside the slider, partially inside the needle and attached to the cover; wherein the slider is arranged to move in relation to the plunger.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end (31a) and a second end (31b) and at least one cover slot (35) along its longitudinal direction; a slider (37) movably arranged inside the cover, having a first end (37a) and a second end (37b); sliding means (36) movably arranged in the cover slot and releasably attached to the slider; a needle (32) having a first end (32a) and a second end, arranged to move within the slider; a plunger (34) arranged inside the slider, partially inside the needle and attached to the cover; and a first elastic element (40) arranged inside the cover to move the slider when the sliding means is released from the slider; wherein the slider is arranged to move in relation to the plunger.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
53.
Long acting drug delivery device and its use in contraception
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
Disclosed are an inserter and an inserter kit for an intrauterine system. The inserter comprises an insertion tube having a first end and an opposite second end, wherein the first end is operable to removably receive the intrauterine system and a handle having a first end portion and an opposite second end portion, the first end portion of the handle is coupled to the second end of the insertion tube. The handle comprises a handling mechanism for controlling movement of the insertion tube with respect to the intrauterine system. The inserter also comprises an indicating mechanism operatively arranged in connection with the insertion tube and the handle, the indicating mechanism is communicably coupled to the handling mechanism and is operable to provide indicative signals corresponding to operational stages of the inserter. The indicative signals comprise at least one light signal and the indicating mechanism comprises a power source.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Title: AN INSERTER FOR AN INTRAUTERINE SYSTEM Abstract: Disclosed are an inserter and an inserter kit for an intrauterine system. The inserter comprises an insertion tube having a first end and an opposite second end, wherein the first end is operable to removably receive the intrauterine system and a handle having a first end portion and an opposite second end portion, the first end portion of the handle is coupled to the second end of the insertion tube. The handle comprises a handling mechanism for controlling movement of the insertion tube with respect to the intrauterine system. The inserter also comprises an indicating mechanism operatively arranged in connection with the insertion tube and the handle, the indicating mechanism is communicably coupled to the handling mechanism and is operable to provide indicative signals corresponding to operational stages of the inserter. The indicative signals comprise at least one light signal and the indicating mechanism comprises a power source.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61F 6/14 - Contraceptive devicesPessariesApplicators therefor for use by females intra-uterine type
An intelligent medical implant and monitoring system includes an implant with a communication device, an inserter for inserting the implant, a reader that operates to broadcast a signal specific to the particular communication device that causes the communication device to respond with a unique identifier, and an external database for storing and providing access to information keyed to the unique identifier of the communication device.
A61F 6/20 - Vas deferens occludersFallopian occluders
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
The present invention relates to an arrangement comprising an intrauterine system, an inserter for the intrauterine system and a package for the inserter, wherein the inserter comprises a handle having a first end and a second end, an insertion tube having a first end and a second end, first handling means for withdrawing the intrauterine system inside the insertion tube and second handling means for expulsing the intrauterine system from the insertion tube; and the package comprises a container, a cover arranged to close the container and means for actioning the first handling means of the inserter.
The present invention relates to an arrangement comprising an intrauterine system, an inserter for the intrauterine system and a package for the inserter, wherein the inserter comprises a handle having a first end and a second end, an insertion tube having a first end and a second end, first handling means for withdrawing the intrauterine system inside the insertion tube and second handling means for expulsing the intrauterine system from the insertion tube; and the package comprises a container, a cover arranged to close the container and means for actioning the first handling means of the inserter.
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterised in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
The present invention relates to a novel thermoplastic polyurethane (TPU) elastomer, T-frames made thereof as well as the use of the new TPU in manufacturing of T-frames for intrauterine systems for contraception and therapy.
C08G 18/24 - Catalysts containing metal compounds of tin
C08G 18/28 - Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.
The present invention relates to a method of manufacturing a vaginal ring, wherein the vaginal ring comprises at least one therapeutically active agent and a body comprising a crosslinked siloxane elastomer. The method comprises manufacturing the body in the form of a rod having a first end and a second end and forming the body into a ring by arranging an attachment part between the first end of the body and the second end of the body, wherein the attachment part comprises a non-crosslinked siloxane elastomer having a weight average molecular weight of 650-850 g/mol and a cross-linking catalyst, and curing the attachment part for a period of time of 1-30 second using a temperature of 125-220°.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
66.
METHOD FOR MANUFACTURING A DRUG DELIVERY DEVICE AND A DRUG DELIVERY DEVICE MANUFACTURED ACCORDING TO THE METHOD
The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical Publications in the field of gynecology such as brochures, magazines and booklets. Conducting scientific studies in the field of gynecology. Medical services in the field of gynecology.
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5—40 wt%, namely 5%, 15% and 30% wt%:of Indomethacin.
A61K 9/00 - Medicinal preparations characterised by special physical form
B29C 67/00 - Shaping techniques not covered by groups , or
80.
NOVEL THERMOPLASTIC POLYURETHANES, USE OF THESE MATERIAL FOR THE PREPARATION OF T-FRAMES FOR INTRAUTERINE SYSTEMS AND T-FRAMES MADE OUT OF THIS MATERIAL
The present invention relates to a novel thermoplastic polyurethane (TPU) elastomer, T-frames made thereof as well as the use of the new TPU in manufacturing of T-frames for intrauterine systems for contraception and therapy.
C08G 18/24 - Catalysts containing metal compounds of tin
C08G 18/28 - Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
A61K 9/00 - Medicinal preparations characterised by special physical form
A61F 6/14 - Contraceptive devicesPessariesApplicators therefor for use by females intra-uterine type
C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterized in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
A61F 6/14 - Contraceptive devicesPessariesApplicators therefor for use by females intra-uterine type
99.
INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION
The present invention relates to intravaginal use of 18-methyl-15ß,16ß-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (I), to an intravaginal ring comprising 18-methyl-15ß,16ß-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (I) and its use in contraception.
The present invention relates to an improved method of contraception which addresses the problems of initial bleeding and spotting associated with the use of intrauterine delivery systems, and to an improved intrauterine delivery system.
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
