MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Müller, Franz-Josef
Brändl, Björn Fabian
Schuldt, Bernhard
Rohrandt, Christian
Van Bömmel, Alena
Kretzmer, Helene
Abstract
The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions: b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The invention relates to a power semiconductor module having a plug-in connection (1). The power semiconductor module has a power module construction (2) so as to connect at least one load connection (3) to an AC load connection (12) via a respective power semiconductor (6), and the power module construction (2) integrates the function of a contact connection and a releasable holding connection into the plug-in connection (5). The invention additionally also relates to the use of a power semiconductor module having a plug-in connection (1).
H05K 5/02 - Casings, cabinets or drawers for electric apparatus Details
H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
H01L 25/07 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in subclass
H02M 7/00 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output
H01L 23/373 - Cooling facilitated by selection of materials for the device
H01R 13/24 - Contacts for co-operating by abutting resilientContacts for co-operating by abutting resiliently mounted
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Muller, Franz-Josef
Brandl, Bjorn Fabian
Schuldt, Bernhard
Rohrandt, Christian
Van Bommel, Alena
Kretzmer, Helene
Abstract
The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions; b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Müller, Franz-Josef
Brändl, Björn Fabian
Schuldt, Bernhard
Rohrandt, Christian
Van Bömmel, Alena
Kretzmer, Helene
Abstract
The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions; b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
5.
APPARATUS HAVING A CONTROL APPARATUS AND METHOD FOR CONTROLLING A POWER SUPPLY OF SAID APPARATUS
The invention relates to an apparatus (100), comprising: - at least one power source (3) for providing electrical power, - at least two consumers (1, 2) of electrical power and - an electronic control apparatus (4) for controlling a supply of the at least two consumers (1, 2) with electrical power from the at least one power source (3), wherein the electronic control apparatus (4) is designed to control the supply of the at least two consumers (1, 2) with electrical power on the basis of a hardware, firmware and/or software-based closed-loop control depending on a state of the at least one power source (3) that is measured and/or determined, in particular calculated, from available technical parameters of the at least one power source (3), wherein the hardware, firmware and/or software-based closed-loop control is designed for external access for a slave control.
A fastening unit for connecting a heat-generating body to a heat sink is provided. The fastening unit includes a retaining pin and a retaining element wherein the retaining pin is connected to a retaining head. The retaining pin extends through the retaining element and the retaining head contacts the retaining element. The retaining element is engageable upon a body of the heat sink so as to retain same in a fastening direction of the retaining pin. The retaining element is engageable laterally on the body of the heat sink, the retaining element having, on a side thereof for facing the body of the heat sink, a retaining groove extending in a longitudinal direction perpendicular to the fastening direction. In an assembled state for the fastening unit, at least one groove surface of the retaining groove of the retaining element contacts the body of the heat sink.
The invention relates to a construction section comprising at least two curved and/or flat wall elements each having two longitudinal edges and two transverse edges, wherein: the wall elements have, on the longitudinal edges, a profiled portion with a cross section and at least two shaped pieces for connecting the wall elements by means of the longitudinal edges of the wall elements; each shaped piece has at least two receptacles each for receiving one longitudinal edge of the wall elements; the receptacle is formed with a cross section that geometrically complements the cross section of the profiled portion of the longitudinal edge of the wall element; and two wall elements are connected to one another by means of one or at least one shaped piece. The invention further relates to a structure and the use of the construction section and/or the structure.
The invention relates to a contact lens with a surface coating, the surface having a contact angle, relative to water or aqueous solutions as the liquid, of less than or equal to 30°, and the contact angle being isotropic relative to a surface of more than 50 μm2. The invention also relates to a method for manufacturing a contact lens with a surface coating.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The invention relates to a cutting device having a housing (28). In this case, a driven disc-shaped cutting tool (10), mounted in the housing (28), for cutting a workpiece (12) is provided. Arranged on a circumferential side of the cutting tool (10) are cutting means (14) that each have an associated cutting edge (14a), said cutting means (14), during cutting, depending on an infeed rate of the cutting tool (10) relative to the workpiece (12), passing into the material to be cut of the workpiece (12) on a cutting-edge entry side of the workpiece (12), passing out on a cutting-edge exit side, remote therefrom, of the workpiece (12), and in the process cutting away material of the workpiece (12). In this case, at least one pressure means is provided, which exerts a pressure (pH) on the surface of the cutting-edge exit side, via a cutting-edge exit face, on the cutting-edge exit side to the side of the cutting tool (10) in the region (18) of the cutting edge (14a), and is mounted in a pivotable manner with respect to the housing (28). According to the invention, the pressure means (24) is mounted in and at one end of at least one swing arm (26). The swing arm (26) is connected to the housing (28) via a first joint (30), wherein the swing arm (26) is mounted so as to be pivotable about a first joint axis of the joint (30). The first joint axis is arranged parallel to the axis of rotation (32) of the cutting tool (10).
B27G 19/10 - Measures preventing splintering of sawn portions of wood
B23D 47/08 - Sawing machines or sawing devices working with circular saw blades, characterised only by constructional features of particular parts of devices for bringing the circular saw blade to the workpiece or removing same therefrom
The invention relates to an antibacterial coating for a medical implant, containing gold alloy and platinum alloy nanoparticles (AuPt nanoparticles), and to a method for producing a corresponding coating.
The invention relates to a fastening unit (10) for connecting thermally stressed components to each other, particularly a heat-generating body (44) having a heat sink (42), comprising a retaining pin (12) and a retaining element (16), wherein the retaining pin (12) is connected to a retaining head (14), the retaining pin (12) extends through the retaining element (16), the retaining head (14) contacts the retaining element (16), and the retaining element (16) engages on the body (44) or heat sink (42) and retains it in a fastening direction (26) of the retaining pin (12). According to the invention, the retaining element (16) is designed to engage laterally on the body (44) or heat sink (42), in that the retaining element (16) has, on the side thereof facing the body (44) or heat sink (42), a retaining groove (24) extending in a longitudinal direction crosswise to the fastening direction, wherein at least one groove surface (24a, 24b) contacts the body (44) or heat sink (42) at least in regions when in the assembled state.
The invention relates to a protective layer which is transparent to visible light, and which is highly scratch resistant and can prevent the adhesion of biofilms and microorganisms (bio-fouling).
C09D 133/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
The invention relates to a filter module (10) for binding particles from a particle-laden material mixture, in particular from an aerosol or from a particle-laden fluid. The invention is based on the approach of deforming an open-pored medium (2), in particular periodically, by means of a relative motion relative to a deformation unit (4, 6; 13, 14) and in this way producing a motion of the material mixture to be filtered through the open-pored medium (2), whereby the material mixture is filtered by the open-pored medium (2). According to a first embodiment concept of the invention, a cylindrical open-pored medium (2) is introduced, together with a deformation unit (4, 6), into a cylindrical housing (1) and said open-pored medium can be deformed geometrically, in particular periodically, preferably at least along the cylinder axis of the housing (1) and/or in the radial direction, by means of the deformation unit (4, 6). According to a second embodiment concept of the invention, a plurality of filter elements (11) are arranged adjacent to each other with respect to the longitudinal extent thereof and are deformed with respect to the longitudinal extent thereof periodically, preferably in an undulating manner, in particular substantially sinusoidally, wherein the deformation motions of the filter elements (11) are phase-shifted with respect to each other.
The present invention relates to a filter arrangement comprising: a filter housing (2) having at least one inflow opening and at least one outflow opening, and provided for a fluid to flow through, wherein the filter housing (2) extends at least substantially along a straight or curved housing axis; at least one filter element (1) arranged inside the filter housing (2), which is provided for the fluid to flow through and to filter same, and which is arranged inside the filter housing (2) in such a way that a straight or curved filter element axis corresponds at least substantially with the housing axis; a number n of first regions, in which an outer wall of the filter element (1) touches an inner wall of the filter housing (2) in a plane at least substantially perpendicular to the housing axis, at least partially, in particular at least substantially completely along the circumference; and a number m of second regions, in which the outer wall of the filter element (1) is separated from the inner wall of the filter housing (2) in a plane at least substantially perpendicular to the housing axis, at least partially, in particular at least substantially completely along the circumference, wherein the first and second regions alternate along the housing axis.
B01D 24/04 - Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof with the filter bed stationary during the filtration the filtering material being clamped between pervious fixed walls
B01D 46/24 - Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
B01D 46/30 - Particle separators, e.g. dust precipitators, using loose filtering material
The invention relates to a coating for applying to organic polymers as a substrate to be coated, wherein the coating mass for forming the coating contains at least one chemical selected from the list comprising metal alcoholates, metal ester, and metal salt, characterized in that the coating mass further contains at least one complexing agent, at least one hydrolysis accelerator, wherein the coating formed from the coating mass contains one or more metal oxides of the metals selected from the list comprising Al, Ga, Ge, Sn, Pb, Ti, Zr, V, Nb, Ta, Mo, W, and Zn. The invention further relates to a method for producing such coatings.
The invention relates to a method for producing a porous surface coating on a substrate, consisting of the following steps: a. a sol/gel or a polymer dissolved in a solution is provided, b. a salt containing nitrate is added to the sol/gel or to the solution, c. the sol/gel containing the nitrate-containing salt or the solution containing the polymer and the nitrate-containing salt is applied as a coating to the substrate, d. the phases are separated, and e. pores are produced in the coating by warming the coating or irradiating with UV light.
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
F24J 2/48 - characterised by the absorber material
F28F 13/08 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by varying the cross-section of the flow channels
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
The invention relates to a catching device for bottom trawl nets and comprises an airfoil-shaped trawl beam (1) and at least two disk-shaped retaining plates (3) which are arranged on the outside of the trawl beam (1) and have connection points for trawls (6), tow ropes (4), and ground chains (9), which, as a result of their mutual geometric arrangement, cause a balance of moments as a function of the hydrostatic and hydrodynamic forces on the seabed (11) and the filling state of the trawl during the trawling operation and thus adapt the trawling resistance of the catching apparatus to the prevailing operating and catching conditions by specifically controlling the profile angle of incidence according to the load. This balance of moments results in a fixed angle of incidence of the airfoil-shaped trawl beam profile (2) and thus produces a defined downforce on the wheel axles (7) in the direction of gravitational force such that the trawl beam is prevented from lifting off the seabed (11).
Substrate having a silver-ion containing titanium oxide coating having a silver content of greater than or equal to 0.2 of Ag/l of Ti to less than or equal to 0.4 of Ag/l of Ti, wherein the coating is X-ray amorphous and the hydrophobicity of the coating can be reduced persistently by illumination.
B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
C09K 3/18 - Materials not provided for elsewhere for application to surface to minimize adherence of ice, mist or water theretoThawing or antifreeze materials for application to surfaces
Substrate having a silver-ion-containing titanium oxide coating having a silver content of greater than or equal to 0.2 of Ag/1 of Ti to less than or equal to 0.4 of Ag/1 of Ti, wherein the coating is X-ray amorphous and the hydrophobicity of the coating can be reduced persistently by illumination.
Disclosed is a semiconductor subassembly for power electronics, comprising an at least partly metallized substrate (10) with at least one semiconductor component (30) that is arranged thereon and is electrically contacted on the bottom face. Said semiconductor subassembly further comprises an electrically insulating polymer film (50) which tightly surrounds the semiconductor component by applying pressure and is made of a polymer that can flow under pressure. The film has slots at predetermined points. At least one metal band (40) is guided through said slots at least once from one side of the film to the other as a contact element and electrically contacts the top face of the semiconductor component.
H01L 21/60 - Attaching leads or other conductive members, to be used for carrying current to or from the device in operation
H01L 23/538 - Arrangements for conducting electric current within the device in operation from one component to another the interconnection structure between a plurality of semiconductor chips being formed on, or in, insulating substrates
H01L 23/31 - Encapsulation, e.g. encapsulating layers, coatings characterised by the arrangement
21.
IMPLANT COMPRISING A BIOTOXIC COATING, AND METHOD FOR THE PRODUCTION THEREOF
Disclosed is a method for producing an implant coating that has a defined toxicity. Said method is characterized by the following steps: i. a sol is produced from a biotoxic solution containing precious metal ions and a precursor solution for a titanium oxide; ii. an implant is coated by applying the sol in a sol-gel process; iii. the coating is pyrolyzed and sintered without admitting any light, the precious metal ion concentration in the dried coating ranging from 10 to 60 percent relative to the total weight of the dried coating; and iv. at least subareas of the coating produced without admitting any light are illuminated in order to reduce the toxicity of the dried coating to a predetermined measure.
Disclosed is a method for producing a substrate for surface-enhanced Raman spectroscopy. Said method comprises the following steps: a sol is produced from a stabilized solution containing precious metal ions and a precursor solution for a titanium oxide; a heat-resistant support is coated by applying the sol by means of a sol-gel process; the layer is pyrolyzed and sintered without using light; and the layer produced without using light is illuminated at least in subareas while at least the illuminated subareas of the layer are simultaneously heated.
patents
