Abstract

Disclosed herein is a method for improving performance of a hypervisor in a memory disaggregation environment. The method includes allocating memory pages to a virtual machine in preset units, comparing the address range of the page frame to be returned with a preset page size, and removing an address space mapping for the page frame to be returned depending on a result of comparison with the preset page size. Removing the address space mapping comprises removing the address space mapping on the basis of contiguous page frames when the range of the page frame to be returned is equal to or greater than the preset page size.

IPC Classes  ?

• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines
• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

The present invention relates to a method for culturing oligodendrocytes, the method comprising: a step for adding an isolation medium to a suspension containing neural stem cells to dissociate tissue; a step for resuspending the dissociated cell suspension by adding a first solution; a step for adding a first solution to the resuspended solution and performing primary centrifugation to obtain a supernatant; a step for adding a second solution to the supernatant and performing secondary centrifugation to obtain a cell pellet; a step for resuspending the cell pellet and then plating same; and a step for culturing the plated cells in a proliferation medium.

IPC Classes  ?

• C12N 5/079 - Neural cells

Abstract

Disclosed herein is a method for managing memory in a memory disaggregation environment. The method includes handling a required subblock within a block more preferentially than an additional block in the event of a page fault and handling a page fault for the block in which the required subblock is preferentially processed.

IPC Classes  ?

• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Bacteroides eggerthiiBacteroides eggerthiiBacteroides eggerthiiBacteroides eggerthiiBacteroides eggerthii strain can serve as a novel means for the prevention, improvement, or treatment of obesity and diseases caused by obesity, such as fatty liver, hepatomegaly, non-alcoholic fatty liver disease, and diabetes.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/74 - Bacteria
• A61P 3/04 - AnorexiantsAntiobesity agents
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The present invention relates to an antidepressant, anti-anxiety, anti-stress, tension-relieving or stress-relieving composition containing a fermented Perilla frutescens extract. In addition, the present invention relates to a fermented Perilla frutescens extract-containing composition for preventing, ameliorating, or treating stress-related disorders, depression, or anxiety. In addition, the present invention relates to a fermented Perilla frutescens extract-containing fiber or fragrance composition for relieving depression, anxiety, tension, or stress. In addition, the present invention relates to a method for treating depression or anxiety, the method comprising administering a fermented Perilla frutescens extract to a patient suffering from a stress-related disorder, depression, or anxiety. A fermented Perilla frutescens (Perilla frutescens Britton var. acuta Kudo (Chajgi), or Perilla frutescens Britton var. crispa Decaisn (Jasoyeop)) extract according to the present invention significantly relieves stress compared to an unfermented Perilla frutescens extract, and thus can be used as an antidepressant, anti-anxiety, tension-relieving or stress-relieving composition, and furthermore, can be effectively used in a composition or therapeutic method for preventing, ameliorating, or treating stress-related disorders, depression, and anxiety.

IPC Classes  ?

• A61K 36/535 - Perilla (beefsteak plant)
• A23L 2/52 - Adding ingredients
• A61K 8/9789 - Magnoliopsida [dicotyledons]
• A61P 25/22 - Anxiolytics
• A61Q 19/00 - Preparations for care of the skin
• C11B 9/02 - Recovery or refining of essential oils from raw materials

Abstract

The present invention relates to: an anti-stress composition comprising at least one extract selected from the group consisting of peppermint extract and Perilla frutescens extract as a natural extract mixture; and a use thereof. Using peppermint extract and Perilla frutescens extract in combination significantly alleviates stress and reduces cortisol levels as compared to using peppermint extract or Perilla frutescens by itself, and thus a natural extract mixture in which peppermint extract and Perilla frutescens extract are mixed together according to the present invention can be effectively used as an anti-stress composition, and furthermore, as a composition for preventing, ameliorating, or treating stress-related diseases, or in a method for preventing or treating stress-related diseases.

IPC Classes  ?

• A61K 36/534 - Mentha (mint)
• A61K 36/535 - Perilla (beefsteak plant)
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to a novel compound which can provide a sleep improving effect or the use thereof. Some compounds have an adenosine receptor agonistic activity. The novel compound of the present invention can shorten sleep latency and extend total sleep duration, and thus may be effectively used for a pharmaceutical composition for preventing or treating a sleep disorder, a health functional food composition for preventing or relieving a sleep disorder, a composition for improving sleep, a sleep aid, or a method for treating a sleep disorder.

IPC Classes  ?

• C07D 239/95 - QuinazolinesHydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61P 25/20 - HypnoticsSedatives
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

A carbon dioxide-epoxide copolymerization catalyst, a method for preparing the carbon dioxide-epoxide copolymerization catalyst, and a carbon dioxide-epoxide copolymerization method are disclosed. The carbon dioxide-epoxide copolymerization catalyst may comprise: a layered thin film part including a zinc-based material; and an organic compound inserted between thin films of the layered thin film part. The method for preparing the carbon dioxide-epoxide copolymerization catalyst may comprise a step of reacting a zinc (II)-based salt and an organic compound.

IPC Classes  ?

• C08G 64/34 - General preparatory processes using carbon dioxide and cyclic ethers
• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds

Abstract

The present invention relates to a novel water-soluble melanin and a method for preparing same. The method for preparing a water-soluble melanin of the present invention can produce a significantly large amount of melanin compared to an existing melanin production method, and, thus, provides good productivity for using a water-soluble melanin commercially. In addition, the water-soluble melanin of the present invention is dissolved in water rather than an organic solvent and can, thus, overcome existing limitations, and has an excellent antioxidant ability, growth inhibitory ability against fungi, and whitening effect compared to other existing synthetic melanins.

IPC Classes  ?

• C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating drug hepatotoxicity diseases and a health functional food composition for preventing or alleviating drug hepatotoxicity diseases and, more specifically, to a pharmaceutical composition for preventing or treating drug hepatotoxicity diseases and a health functional food composition for preventing or alleviating drug hepatotoxicity diseases, each composition comprising Slit2 protein or a nucleic acid coding therefor as an active ingredient. The present invention relates to a composition of VEGF-GRAB.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A23L 33/17 - Amino acids, peptides or proteins

Abstract

The present invention relates to a composition for diagnosing liver cancer using a methylation change of a SORT1 gene promoter and a use thereof, and the present invention has enabled: establishment of a systematic research method and technique for investigating growth and proliferation of liver cancer, apoptosis, metastasis inhibition, and a signaling pathway; confirmation of whether SORT1, which is a target gene, shows clinical significance, on the basis of a basic experiment; and prediction or diagnosis of liver cancer with high accuracy by measuring the methylation degree of the SORT1 gene, specifically cg16988986 in a promoter region of the SORT1 gene. Therefore, a methylation change of the SORT1 gene promoter is highly likely to be used as a target for diagnosing liver cancer.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention provides a road surface temperature control apparatus which controls the temperature of a road surface by transferring geothermal heat to the road to remove snow accumulated on the road and exchanging heat between the underground and the road surface through a working fluid when the temperature of the road rises by solar radiation in summer. The road surface temperature control apparatus is an apparatus for adjusting the temperature of the road surface by exchanging heat of the road on the ground with the geothermal heat in the underground, and comprises: an underground heat exchanging means which is arranged underground and absorbs the geothermal heat; and a road surface heat exchanging means which is arranged on the road and supplies the heat absorbed by the underground heat exchanging means to allow the heat to be exchanged with the heat of the road surface.

IPC Classes  ?

• E01C 11/26 - Permanently-installed heating or blowing devices
• E01H 5/10 - Removing snow or ice from roads or like surfacesGrading or roughening snow or ice by application of heat
• F24T 10/10 - Geothermal collectors with circulation of working fluids through underground channels, the working fluids not coming into direct contact with the ground
• F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure

Abstract

An embodiment of the disclosure provides a plasma coating method of a nanovesicle surface and a plasma jet device for plasma coating of a nanovesicle surface. The plasma coating method of a nanovesicle surface according to an embodiment of the disclosure may be provided as a simple method for changing the surface charge of a nanovesicle from negative to neutral by utilizing the characteristic that when a neutral object meets a negatively charged object, electrons of the neutral object repel electrons of the negatively charged object and the negatively charged object becomes positively charged.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor

Abstract

The present invention relates to a bio-indigo production method using an eco-friendly bio-process. A bio-indigo production process, which increases solubility of indole and indigo by using a surfactant and a reducing agent, and continuously bio-converts indole into indigo, has been developed. Adsorbents and reducing agents enabled efficient removal and solubilization of indigo, respectively, and thereby enabled high yields of the bio-indigo production process. An adsorbent removal process and the use of an eco-friendly reducing agent can be easily applied to mass production of bio-indigo, and are expected to be widely utilized industrially such as in adsorbent recovery, indigo separation, continuous reaction, and bio-dyeing processes.

IPC Classes  ?

• C12P 17/16 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing two or more hetero rings
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C09B 7/00 - Indigoid dyes
• C09B 67/28 - Preparations of vat or sulfur dyes
• C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria

Abstract

Disclosed are a retroreflective signal analysis-type biosensor chip for bacterial detection, a food pathogenic bacteria detection chip, a retroreflective signal analysis-type bacterial detection method, and a food pathogenic bacteria detection method. The retroreflective signal analysis-type biosensor chip for bacterial detection may comprise: a fluid chip including a flow path therein; an injection unit which is connected to the flow path and injects a sample to be detected including retroreflective particles modified with a first antibody capable of binding to bacteria to be detected; and a detection unit in which a second antibody capable of binding to the bacteria to be detected is immobilized on the inner surface of the flow path.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/55 - Specular reflectivity

Abstract

Provided is a method of forming an insulating film on a substrate by using atomic layer deposition (ALD). The method of forming an insulating film on a substrate by using ALD includes transferring a deposition-hindering material to the substrate, and depositing a first material layer by transferring a first precursor to the deposition-hindering material, wherein the deposition-hindering material includes an organic ligand, and the first precursor includes an alkoxide ligand.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C23C 16/34 - Nitrides
• C23C 16/40 - Oxides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

Provided are an apparatus and method for decoding a successive cancellation list of polar codes by using power gating. The apparatus for decoding a successive cancellation list of polar codes by using power gating according to an embodiment comprises: a plurality of successive cancellation list decoding units that receive polar-encoded codes and decode the codes by using a successive cancellation list technique; and a power gating circuit unit that is connected to a preset number of successive cancellation list decoding units among the plurality of successive cancellation list decoding units and controls the supply of current.

IPC Classes  ?

• H03M 13/13 - Linear codes
• H03M 13/37 - Decoding methods or techniques, not specific to the particular type of coding provided for in groups
• H03M 13/45 - Soft decoding, i.e. using symbol reliability information
• H03K 19/00 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits

Abstract

The present disclosure relates to a positioning method of a terminal, using multiple low earth orbit (LEO) satellites. The positioning method may comprise the steps of: receiving a signal from each of one or more LEO satellites; acquiring ephemeris data of each of the LEO satellites; determining the Doppler shift on the basis of the ephemeris data and the signal; determining state variables and at least one factor to be used in factor graph optimization; and acquiring a positioning result using the factor graph optimization on the basis of the Doppler shift.

IPC Classes  ?

• G01S 19/42 - Determining position
• G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using radio waves

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating liver cirrhosis comprising Isosakuranetin or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the pharmaceutical composition can inhibit the death of hepatocytes and suppress the increase in GOT, GPT, ALP, or total cholesterol as liver cirrhosis or hepatic fibrosis cells are treated with Isosakuranetin.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to a dental zirconia material of which the surface is modified by plasma treatment, an implant, and a method for preparing same. The zirconia material and the implant prepared according to the present invention have improved cell adhesion and anti-bacterial effect, and thus can exhibit improved biocompatibility and minimize an inflammatory response of a user and the like.

IPC Classes  ?

• C04B 41/00 - After-treatment of mortars, concrete, artificial stone or ceramicsTreatment of natural stone
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
• C04B 35/48 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates

Abstract

An apparatus for diagnosing failure of an inverter includes switches coupled to three phases of A, B, and C, respectively. The apparatus also includes a measurer configured to measure each of the output currents of the three phases. The apparatus also includes a comparison processor configured to receive the output currents measured by the measurer and compare the received output currents with a set value. The apparatus also includes a failure determination processor configured to detect a switch having an output current equal to or smaller than the set value based on the comparison performed by the comparison processor to determine the switch as faulty. The failure determination processor is also configured to, upon detecting faulty switch, identify which phase switch is faulty to change the duty ratio of the switch determined to be faulty and to perform phase shift on switches not determined to be faulty.

IPC Classes  ?

• H02M 1/32 - Means for protecting converters other than by automatic disconnection
• G01R 31/327 - Testing of circuit interrupters, switches or circuit-breakers
• H02M 7/5395 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation

Abstract

The present invention relates to a chimeric antigen receptor (CAR) binding to PD-L1 of tumor cells and a composition for treating cancer using T cells transformed with an anti-PD-L1 CAR and provides T cells expressing a chimeric antigen receptor binding specifically to PD-L1 overexpressed in various solid cancers. Moreover, in the present invention, T cells are provided with a means capable of selectively expressing a cytokine increasing anticancer efficacy together with a site encoding an anti-PD-L1 chimeric antigen receptor. In addition, the present invention provides a cell therapeutic composition for preventing or treating cancer, the composition comprising T cells expressing the anti-PD-L1 chimeric antigen receptor prepared according to the present invention.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C07K 14/725 - T-cell receptors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 14/55 - IL-2
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a glycerol dehydratase variant and, more specifically, to a fusion glycerol dehydratase variant alleviating the inactivation of coenzyme B12 by oxygen or improving activity for glycerol, which is a substrate, and thus exhibits excellent activity even under conditions of low coenzyme B12 concentration.

IPC Classes  ?

• C12N 9/88 - Lyases (4.)
• C12P 7/52 - Propionic acidButyric acids

Abstract

A network intrusion detection system includes: a data collection unit configured to obtain a dataset for training a plurality of machine learning-based heterogeneous models included in the network intrusion detection system; a clustering module configured to cluster data points included in the obtained dataset; a routing module configured to selectively input the data points into at least one of the plurality of models based on a result of the clustering; and a model training unit configured to define a loss function based on a reconstruction loss of each of the at least one model for an input data point, and perform an update of each of the at least one model so that the defined loss function is minimized, wherein the model training unit sets an anomaly threshold for each of the at least one model based on loss distribution of reconstruction losses for the data points.

IPC Classes  ?

• H04L 9/40 - Network security protocols

Abstract

Disclosed herein is beam selection in a system supporting satellite communication. A method of performing beam selection of a user equipment (UE) in a communication system supporting satellite communication may include receiving first information about an elevation angle for supporting the satellite communication and second information about a beam center, determining coverage of a beam based on the first information and the second information, determining a distance between the UE and the beam center based on the second information, and selecting a serving beam for the UE based on the coverage of the beam and the distance.

IPC Classes  ?

• H04W 16/28 - Cell structures using beam steering
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

The present invention relates to a dental titanium material having a surface modified through plasma treatment; an implant; and a preparation method therefor. The titanium material and the implant prepared according to the present invention have improved cell adhesion and antimicrobial effect so that biocompatibility is improved and the inflammatory response of a user and the like can be minimized.

IPC Classes  ?

• C22F 1/18 - High-melting or refractory metals or alloys based thereon
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
• A61C 13/00 - Dental prosthesesMaking same

Abstract

An image rectification system according to an aspect of the inventive concept includes: a distortion characteristic estimation module configured to divide an input image into a plurality of cells and estimate a distortion characteristic of each of the plurality of divided cells; a rectification information generation module configured to generate rectification information for each of the plurality of cells based on estimated distortion characteristic and reference information for rectification; and an image conversion configured to obtain a parameter for rectification for each of the plurality of cells and alignment of rectified cells based on the generated rectification information, and perform rectification on the input image based on the obtained parameter.

IPC Classes  ?

• G06T 5/80 - Geometric correction
• G06V 10/98 - Detection or correction of errors, e.g. by rescanning the pattern or by human interventionEvaluation of the quality of the acquired patterns

Abstract

The present invention relates to a peptide for detecting CA125 and use thereof and, more specifically, to a peptide for detecting CA125 that specifically binds to CA125 and use thereof for diagnosing ovarian cancer. The peptide that specifically binds to CA125, according to the present invention, can detect CA125 with high sensitivity and accuracy. In addition, when the peptide is expressed in the outer coat of a bacteriophage and constructed into a bacteriophage nano self-assembly, the peptide can conveniently detect CA125 from a sample through observation of a color change with a simple imaging device such as a smartphone, and in particular, the peptide can detect CA125 included in a small amount in saliva, and thus has the advantage of being very effectively used in early diagnosis of ovarian cancer.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/554 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells

Abstract

The present invention relates to a novel compound capable of inducing osteogenic differentiation of stem cells and, more particularly, to a compound of chemical formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and a composition for inducing osteogenic differentiation of stem cells, comprising the compound, the stereoisomer thereof or the pharmaceutically acceptable salt thereof. The novel compound based on nutlin, according to the present invention, induces the degradation of MDM2 to efficiently promote the differentiation of mesenchymal stromal cells, and thus, the effect of inducing osteogenic differentiation of stem cells is excellent.

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 19/00 - Drugs for skeletal disorders

Abstract

222, wherein the first layers and the second layers are alternately stacked.

IPC Classes  ?

• H10B 53/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the memory core region
• H10B 53/20 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the three-dimensional arrangements, e.g. with cells on different height levels
• H10N 97/00 - Electric solid-state thin-film or thick-film devices, not otherwise provided for
• G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements

Abstract

The present invention provides a biomarker for diagnosing anaphylaxis for shrimps by identifying allergens specific to anaphylaxis among allergens derived from shrimps for Koreans. The present invention provides a composition capable of diagnosing anaphylaxis for shrimps by identifying allergens specific to anaphylaxis of Koreans among allergens derived from shrimps and identifying an epitope which is an epitope to which IgE causing anaphylaxis binds in the allergens.

IPC Classes  ?

• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A method of scoring suspects in a criminal case includes: obtaining a case network including a plurality of case nodes corresponding to a plurality of cases and a plurality of edges connecting different case nodes; obtaining a people network including a plurality of person nodes corresponding to a plurality of people and a plurality of edges connecting different person nodes, constructing a crime network connecting the case network and the people network through a case-person edge based on association information between a case and a person, and scoring candidate suspects using the crime network when information about a new case is obtained.

IPC Classes  ?

• G06N 5/022 - Knowledge engineeringKnowledge acquisition
• G06Q 50/26 - Government or public services

Abstract

A pixelated monolithic photoplethysmographic (PPG) sensor with a spiking neural network structure and a driving method thereof are disclosed. The pixelated monolithic photoplethysmographic (PPG) sensor according to an exemplary embodiment of the present disclosure includes a plurality of input neurons which generates spike signals and is disposed in at least one of a row direction and a column direction, a plurality of output neurons which adds the spike signals applied from the plurality of input neurons based on the column direction or the row direction and generates an output spike signal when the added result is equal to or higher than a predetermined reference value, and a synchronizer which converts each of the output spike signals into a digital signal.

IPC Classes  ?

• H04N 25/10 - Circuitry of solid-state image sensors [SSIS]Control thereof for transforming different wavelengths into image signals
• H04N 25/77 - Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components

Abstract

The present invention relates to a composition containing 2-deoxy-D-glucose as an active ingredient for inhibiting skin aging.

IPC Classes  ?

• A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
• A61P 17/00 - Drugs for dermatological disorders
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates

Abstract

The present invention relates to a T cell engaging bispecific antibody. More particularly, the present invention relates to: a bispecific antibody that simultaneously binds to human interleukin-5 (IL-5) receptor alpha subunit (IL-5Rα), which is a receptor of human IL-5, and CD3ε, which is a human T cell marker; a nucleic acid encoding same; a vector comprising the nucleic acid; a cell transformed with the vector; a method for producing the bispecific antibody or; a composition comprising same for the prevention or treatment of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils; and a composition comprising same for the diagnosis of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present application relates to a double metal cyanide catalyst with a Zn-OR group, and a double metal cyanide catalyst with a zinc acetate group.

IPC Classes  ?

• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• C08G 64/34 - General preparatory processes using carbon dioxide and cyclic ethers
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 27/26 - Cyanides
• B01J 37/04 - Mixing

Abstract

The present invention relates to a novel blood biomarker GULP1 for diagnosing liver cancer and use thereof, and to use of GULP1, the expression of which specifically changes in hepatocellular carcinoma, as a biomarker for diagnosing liver cancer. In particular, since GULP1 expression specifically changes in liver cancer, GULP1 can be used as a hepatocellular carcinoma-specific marker, and it was confirmed that, when used alone or in combination with AFP, GULP1 had the effect of diagnosing and predicting hepatocellular carcinoma more specifically and accurately. Therefore, GULP1 discovered in the present invention is highly likely to be used as a target for treating liver cancer.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a composition including a GULP1 inhibitor as an active ingredient for the prevention or treatment of recurrent liver cancer. GULP1 associated with liver cancer recurrence was derived, and it was confirmed that selective inhibition of GULP1 effectively suppresses the proliferation, migration, and metastasis of liver cancer, particularly preventing the recurrence of liver cancer. As for the mechanism, the inhibition of GULP1 leads to interference with the binding of GULP1 to ARF6, thereby reducing the protein stability of ARF6-GTP and suppressing ARF6 activation, which in turn inhibits β-catenin activity, ultimately controlling the progression of EMT. Therefore, when used, the GULP1 inhibitor can prevent the progression and recurrence of liver cancer and thus may be as a highly promising new therapeutic option for liver cancer.

IPC Classes  ?

• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/13 - Nucleic acids or derivatives thereof
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

A cell-penetrating degrading antibody is disclosed. In the cell-penetrating degrading antibody, U-Box of E3 that can bind to E2 of an ubiquitin-proteasome system (UPS), which is an intracellular protein degradation system, or an E3 recruiter (E3 recruiting ligand) that can bind to E3 of the UPS is fused to a cell-penetrating interfering antibody that penetrates into the cytosol of living cells and specifically recognizes a target protein. A composition containing the cell-penetrating antibody and uses thereof are disclosed.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The present application relates to a pharmaceutical composition for the prevention or treatment of cancer, being capable of overcoming resistance in subjects that exhibit resistance to immune checkpoint inhibitors and enhancing anti-tumor immunity. The composition comprises an AXL kinase inhibitor and an immune checkpoint inhibitor.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a peptide for detecting HE4 and use thereof and, more specifically, to a peptide for detecting HE4 that specifically binds to HE4 and use thereof for diagnosing ovarian cancer. The peptide that specifically binds to HE4, according to the present invention, can detect HE4 with high sensitivity and accuracy. In addition, when the peptide is expressed in the outer coat of a bacteriophage and constructed into a bacteriophage nano self-assembly, the peptide can conveniently detect HE4 from a sample through observation of a color change with a simple imaging device such as a smartphone, and in particular, the peptide can detect HE4 included in a small amount in saliva, and thus has the advantage of being very effectively used in early diagnosis of ovarian cancer.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/544 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
• G01N 33/553 - Metal or metal coated

Abstract

The present invention relates to a biomarker composition for the diagnosis of chronic spontaneous urticaria, comprising heat shock protein 10 (HSP10) or an antibody thereof as an active ingredient. Through confirmation of differences in the levels of HSP10, anti-Hsp10 IgG and miR-101-5p in the serum of healthy controls and patients with chronic spontaneous urticaria, HSP10, anti-Hsp10 IgG, and miR-101-5p are provided as novel biomarkers capable of diagnosing chronic spontaneous urticaria.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present application relates to a gas sensor comprising: a first oxide layer; a second oxide layer disposed on the first oxide layer; an inactive electrode formed at the interface between the first oxide layer and the second oxide layer; and an active electrode disposed on the second oxide layer, wherein the inactive electrode comprises a two-dimensional electron gas (2DEG) layer, and inside the second oxide layer, a metal filament that connects the active electrode and the inactive electrode and is derived from the active electrode is included.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The present invention relates to a composition comprising a low-molecular-weight compound as an active ingredient for preventing or treating cancer. Cancer is one of the most common causes of death worldwide, and there has been ongoing effort to discover new chemical anticancer agents beyond those traditionally used. The compounds provided in the present invention effectively inhibit the activity of isocitrate dehydrogenase or malic enzyme, thereby suppressing the survival of cancer cells and inducing their apoptosis. Thus, the compounds are expected to be actively used in the medical and healthcare fields.

IPC Classes  ?

• A61K 33/24 - Heavy metalsCompounds thereof
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/16 - Inorganic salts, minerals or trace elements

Abstract

The present invention relates to humanized antibodies targeting human EphA10 and use thereof. The antibody specific to EphA10 or an immunologically active fragment thereof according to the present invention specifically bind to EphA10, a highly promising target for overcoming resistance and non-responsiveness to existing immune checkpoint inhibitor therapies. When created with the antibody, an ADC was found to specifically kill cancer cells. Therefore, it can be used as a therapeutic antibody for cancer treatment leveraging cancer cell death mechanisms via immune cell activation or for treating EphA10-expressing cancers, or as a cell therapeutic for treating EphA10-expressing cancers, and can also be used for cancer diagnosis.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C07K 14/725 - T-cell receptors
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to an injection formulation composition for use as a filler or a drug carrier through a click chemistry reaction. More specifically, the present invention relates to an injection formulation composition comprising: a first liquid comprising a first biopolymer having a first click chemistry functional group introduced thereinto; and a second liquid comprising a second biopolymer having a second click chemistry functional group introduced thereinto, wherein the first click chemistry functional group is chemically linkable with the second click chemistry functional group, to a method for preparing an injection formulation hydrogel using the composition, and to a medical filler, an in-vivo injection type supporter, or a drug carrier using the composition.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/20 - Polysaccharides
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials

Abstract

An inflammasome activates caspase-1 for cytokine maturation and cell death, and thus induces host defense in cells. An NLRP3 inflammasome promotes the release of highly inflammatory cytokines IL-1β and IL-18 to induce gasdermin D-mediated pyroptosis (pyroptotic cell death), and thus is involved in inflammatory processes. Therefore, targeting an NLRP3 pathway and modulating relevant immune responses can be a promising strategy for designing drug candidates for inflammatory diseases. A rationally designed α2-helix-based peptide NIP3 inhibits the NLRP3 pathway. NIP3 has remarkably inhibited both the secretion of NLRP3-induced IL-1β and IL-18 and the expression of downstream proteins in lipopolysaccharide-primed nigericin-activated THP-1 cells. In addition, binding energy data suggests that NIP3 has a stronger affinity for ASCPYD than for NLRP3PYD. Therefore, according to empirical and in silico results, NIP3 exclusively inhibits the NLRP3-ASC-caspase-1 pathway.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

A method, performed by a health management server, for evaluating a health condition by using a skeleton model. In detail, the method comprises the steps of: providing, to a user apparatus, a standard motion image of a trainer performing a standard motion; receiving, from the user apparatus, a user motion image of a user motion performed by a user following the standard motion; calculating a similarity between the standard motion and the user motion by comparing the standard motion image with the user motion image; and evaluating a health condition of the user on the basis of the calculated similarity.

IPC Classes  ?

• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G06T 7/00 - Image analysis

Abstract

A plasma etching method is disclosed. The plasma etching method may comprise: a first step of vaporizing liquid heptafluoroisopropyl methyl ether (HFE-347mmy); a second step of supplying a discharge gas containing the vaporized HFE-347mmy, oxygen gas, and argon gas to a plasma chamber where an object to be etched is placed; and a third step of discharging the discharge gas to generate plasma, and subjecting the object to be etched to plasma etching using the plasma.

IPC Classes  ?

• H01L 21/311 - Etching the insulating layers
• H01L 21/3065 - Plasma etchingReactive-ion etching
• C09K 13/00 - Etching, surface-brightening or pickling compositions

Abstract

Disclosed are a federated learning method and device using device clustering. The federated learning method includes obtaining an arbitrary client group including some clients as a result of performing clustering on a plurality of clients; determining one of the some clients as a leader client based on a centroid associated with the clustering, wherein the leader client receives data associated with at least one parameter of a pre-trained model from each of the some clients; determining at least one client among the some clients as a target client based on an amount of computing resources of the pre-trained model and a training loss of the pre-trained model; and receiving some data associated with at least one parameter of the model of the target client from the leader client, wherein the some data is included in the data.

IPC Classes  ?

• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

Provided is a method for providing information on chronic urticaria and, more specifically, the provided is a method for diagnosing chronic urticaria by measuring an allergen-specific IgE antibody for a vesicle derived from Acinetobacter bacteria; a diagnostic composition using the same; and the like.

IPC Classes  ?

• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating inflammation comprising a glucocorticoid compound. The novel glucocorticoid compound of the present invention is expected to be widely used in the medical field as the glucocorticoid compound has a significant anti-inflammatory effect at a lower concentration compared to conventional glucocorticoid compounds.

IPC Classes  ?

• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 8/63 - SteroidsDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin

Abstract

The present invention relates to use of N6-methyladenosine-modified RP11-108M9.4 for diagnosing or treating recurrent liver cancer. RP11-108M9.4, which is a long non-coding RNA, was presented as a marker for predicting liver cancer recurrence and verified to have the ability to regulate metastasis/recurrence. In addition, the top molecular marker of RP11-108M9.4 was identified by chemical modification. In particular, RP11-108M9.4, which is a non-coding RNA related to liver cancer recurrence, presented in the present invention, is a novel RNA molecule that has not been previously reported, and by identifying the network between cancer cells and establishing various networks of the non-coding RNA by chemical modification, a new mechanism of liver cancer occurrence and metastasis/recurrence was presented through verification in in-vitro and animal experiments. Therefore, RP11-108M9.4 discovered in the present invention is highly likely to be used as a target for treating liver cancer recurrence or metastasis.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

The present invention relates to a composition, a fiber or a fragrance composition for improving cognitive ability or memory ability, containing a fermented Perilla frutescens extract. In addition, the present invention relates to a composition for preventing, alleviating or treating cognitive ability- or memory ability-related diseases, containing a fermented Perilla frutescens extract. Furthermore, the present invention relates to a method for treating cognitive ability- or memory ability-related diseases, comprising a step of administering a fermented Perilla frutescens extract to a patient with a cognitive ability- or memory ability-related disease. Compared to an unfermented Perilla frutescens extract, a fermented Perilla frutescens extract of the present invention significantly increases cognitive ability or memory ability, thereby being effectively usable as a composition for improving cognitive ability or memory ability. Moreover, a fermented Perilla frutescens extract of the present invention can be effectively used in a composition for preventing, alleviating or treating cognitive ability- or memory ability-related diseases, or in a treatment method.

IPC Classes  ?

• A61K 36/535 - Perilla (beefsteak plant)
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C11B 9/00 - Essential oilsPerfumes
• D06P 1/34 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using natural dyestuffs

Abstract

A method of manufacturing, by atomic layer deposition, an electrode including a perovskite type crystal structure represented by Formula 1, includes: forming a vanadium-containing precursor on a substrate; forming a vanadium-containing intermediate phase by reacting the vanadium-containing precursor with oxygen molecules; and forming a first thin film by reacting the vanadium-containing intermediate phase with water. A method of manufacturing, by atomic layer deposition, an electrode including a perovskite type crystal structure represented by Formula 1, includes: forming a vanadium-containing precursor on a substrate; forming a vanadium-containing intermediate phase by reacting the vanadium-containing precursor with oxygen molecules; and forming a first thin film by reacting the vanadium-containing intermediate phase with water. wherein, in Formula 1, 0.3≤x≤0.7, and 2.5≤y≤3.0.

IPC Classes  ?

• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The present invention relates to a composition for preventing or treating inflammatory bowel disease. More specifically, the present invention provides a pharmaceutical composition and a health food composition for preventing or treating inflammatory bowel disease, comprising, as active ingredients, two or more strains selected from the group consisting of Tetragenococcus halophilus, Eubacterium rectale and Lactobacillus animalis; and cultures of the strains, concentrates of the cultures, extracts of the cultures, or lysates thereof. The composition comprises two or more strains having anti-inflammatory activity as an active ingredient and regulates immune cells related to inflammatory bowel disease, thereby preventing, ameliorating or treating inflammatory bowel disease more effectively than a single strain.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

The present invention relates to a novel mifepristone derivative compound and various uses thereof. In order to develop an effective therapeutic agent for cancer, it is necessary to simultaneously inhibit the growth and metastasis of cancer cells. Generally, cancer growth means the characteristic of cancer cells to endlessly proliferate, and cancer metastasis means the characteristic of cancer cells to separate from a primary site and move to another location. Therefore, cancer growth and cancer metastasis require approaches of different mechanisms. A compound provided in the present invention can simultaneously inhibit the proliferation and metastasis of cancer, and thus is expected to have active applicability in the medical and health fields.

IPC Classes  ?

• C07J 3/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by one carbon atom
• C07J 1/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
• C07J 7/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms
• A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a composition for the prevention or treatment of cancer, comprising as active ingredients indazolyl ester and amide derivatives that are highly reactive against cancer, particularly lung cancer. Cancers are one of the most common causes of death worldwide. Among the cancers, lung cancer remains the most lethal malignant tumor in the world. Despite improvements in surgical treatment, systemic treatment, and radiation therapy, the 5-year survival rate for all patients diagnosed with lung cancer is approximately 15-20%. Since the compounds provided in the present invention exhibit high reactivity against intractable lung cancer, the compounds are expected to be actively used in the medical and health fields.

IPC Classes  ?

• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

In an embodiment, a vehicle includes a plurality of sensors for obtaining surrounding environment information including a nearby object information or a road information. A processor is in operative connection with the plurality of sensors. The processor is configured to predict a position change of a nearby object based on the surrounding environment information, and determine one among a plurality of avoidance behavior types for avoiding collision in a lane as an avoidance behavior type of the vehicle based on the predicted position change of the nearby object, wherein the plurality of avoidance behavior types comprises an evasive steering to right (ESR) type, an evasive steering to left (ESL) type, or a decelerating (DEC) type.

IPC Classes  ?

• B60W 30/09 - Taking automatic action to avoid collision, e.g. braking and steering
• B60W 30/095 - Predicting travel path or likelihood of collision
• B60W 30/16 - Control of distance between vehicles, e.g. keeping a distance to preceding vehicle
• B60W 40/06 - Road conditions
• B60W 50/00 - Details of control systems for road vehicle drive control not related to the control of a particular sub-unit
• B60W 50/14 - Means for informing the driver, warning the driver or prompting a driver intervention
• G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestriansRecognition of traffic objects, e.g. traffic signs, traffic lights or roads

Abstract

The present invention relates to a novel mifepristone derivative compound and various uses thereof. In order to develop an effective cancer treatment, a treatment that simultaneously suppresses the growth and metastasis of cancer cells must be developed. In general, cancer growth refers to the property of cancer cells to infinitely proliferate, and cancer metastasis refers to the property of cancer cells to separate from the primary site and move to other locations. Thus, cancer growth and cancer metastasis require different mechanistic approaches. The compound provided by the present invention can simultaneously suppress cancer proliferation and metastasis, and thus is expected to be actively used in the medical and health fields.

IPC Classes  ?

• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 31/569 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone substituted in position 17 alpha, e.g. ethisterone
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present disclosure relates to a composition for preventing or treating ischemic cerebrovascular disease, and more specifically to a composition for preventing or treating ischemic cerebrovascular disease including an arginase-1 inhibitor as an active ingredient, and the arginase-1 inhibitor according to the present disclosure can alleviate pathological damage caused by the interaction of inflammatory cells after ischemic stroke and promote functional recovery by inhibiting the expression and function of cell-specific arginase-1 protein.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a composition containing silver sulfadiazine for the prevention, alleviation, or treatment of fatty liver. Silver sulfadiazine can increase the expression of genes related to fatty acid oxidation and inhibit lipid accumulation in hepatocytes without toxicity, and thus can be utilized to prevent, alleviate, or treat fatty liver or steatohepatitis.

IPC Classes  ?

• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
• A61K 33/38 - SilverCompounds thereof
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/16 - Inorganic salts, minerals or trace elements

Abstract

The present invention relates to a novel composition for inhibiting histone deacetylase (HDAC). Silver sulfadiazine of the present invention has an excellent HDAC activity inhibitory ability, and thus can be used as an HDAC inhibitor, and can be used in a therapeutic agent for various associated diseases (for example, metabolic diseases such as obesity and diabetes) through the inhibition of HDAC activity.

IPC Classes  ?

• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
• A61K 33/38 - SilverCompounds thereof
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The electronic device for performing digital forensics on an in-vehicle infotainment environment according to an exemplary embodiment of the present invention includes a processor which identifies each specification information of an in-vehicle infotainment (IVI) system installed in a vehicle and a user terminal communicating with the IVI system, collects communication section data generated in a communication section between the IVI system and the user terminal, first device data of the IVI system and second device data of the user terminal through collection methods prepared in response to the specification information, extracts artifacts associated with the in-vehicle infotainment environment by analyzing the communication section data, the first device data and the second device data through analysis methods prepared in response to the specification information, and verifies the artifacts through mutual comparison between the communication section data, the first device data and the second device data.

IPC Classes  ?

• H04N 21/414 - Specialised client platforms, e.g. receiver in car or embedded in a mobile appliance

Abstract

The present invention relates to a composition for prevention and treatment of inflammatory eye disease, comprising highly concentrated oxygen water as an active ingredient, and a method for prevention and treatment of inflammatory eye disease using the composition. The composition comprises highly concentrated oxygen water, and when a human corneal cell line is treated therewith immediately after having dry eye induced, a rapid wound healing speed is exhibited compared to a control group, and the composition inhibits the expression of inflammatory cytokines such as TNF-α, IL-1β, IL-8, and IFN-γ and thus may exhibit a high therapeutic effect for inflammatory eye disease.

IPC Classes  ?

• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A bolometer device is disclosed. The bolometer device comprises: a substrate; a sensing layer in which an aluminum doping vanadium oxide layer and an aluminum oxide layer are alternately stacked; and a first electrode and a second electrode spaced apart from each other on the substrate and being in contact with different parts of the sensing layer, respectively.

IPC Classes  ?

• G01J 5/08 - Optical arrangements
• G01J 5/02 - Constructional details
• G01J 5/20 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using resistors, thermistors or semiconductors sensitive to radiation, e.g. photoconductive devices

Abstract

Disclosed herein non-infrastructure ultra-wideband wireless positioning method and system using latency communication and overhear. The method includes: receiving a ranging message transmitted from other active devices; measuring a location of an active device by using data obtained from the ranging message; checking a remaining amount of power of the active device and creating a ranging message by using the remaining amount of power of the active device and the obtained data; and transmitting the created ranging message to the other active devices. When a request of device change is received from a first passive device based on a remaining amount of power of a passive device overhearing the ranging message and the remaining amount of power of the active device, a response for changing the first passive device to an active device is provided, and the active device itself changes from an active device to a passive device.

IPC Classes  ?

• H04W 52/02 - Power saving arrangements
• H04L 5/00 - Arrangements affording multiple use of the transmission path
• H04W 48/04 - Access restriction performed under specific conditions based on user or terminal location or mobility data, e.g. moving direction or speed

Abstract

The present invention provides a cell measurement device and method in which retroreflective particles are introduced to measure cells, and thus, an optical signal is obtained without fixing of life activity of cells and performing a separate staining process. An example of the use of retroreflection-based cytometry is evaluation of cell migration. The cells capture the retroreflective particles during cell migration or growth, and migrate in a state that the particles are captured in the cell or bind to the cells. The migrated cells are observed in a form of bright dots inside the cells under irradiation of white light as a non-spectroscopic light source to the cells in the retroreflective optical system. The number of bright spots is counted, and thus, the number of cells and the presence thereof thus can be easily measured based on an image.

IPC Classes  ?

• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 15/1434 - Optical arrangements
• G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
• G01N 33/483 - Physical analysis of biological material

Abstract

The present invention relates to a composition for preventing or treating inflammatory skin diseases, containing a 1H-pyrazole-3-amide compound derivative. Found to reduce TNF-α, IL-1β, IL-17A, and Ki67 in the skin of mouse models of psoriasis or contact dermatitis, the composition can prevent or treat such inflammatory skin diseases by effectively inhibiting psoriasis or contact dermatitis.

IPC Classes  ?

• A61K 31/415 - 1,2-Diazoles
• A61P 17/00 - Drugs for dermatological disorders
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present disclosure relates to a composition for treating osteoarthritis or eliminating senescent cells, including K-7174 that targets zinc finger MIZ domain-containing protein 1 (Zmiz1) as an active ingredient, wherein suppression of overexpression of Zmiz1 found in osteoarthritis-induced joint tissues or mice as well as suppression of expression, due to binding between K-7174 and GATA whose expression is induced by the Zmiz1 overexpression, of joint destructing factors (Mmp3, Cox2) and senescence cell promoting factors (Glb1, p16) whose expressions are increased upon the overexpression have shown effects of decreasing the progression of osteoarthritis and promoting elimination of senescent cells, such that it is possible to provide a composition including the K-7174 as an active ingredient as a treatment for osteoarthritis or an agent for eliminating senescent cells.

IPC Classes  ?

• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

According to the present invention, disclosed are a disease diagnosis system using real images of peripheral parts of the eyes and a control method therefor, wherein the disease diagnosis system comprises: a data storage unit that receives real images obtained by photographing peripheral parts of eyes of a patient suffering from a specific disease, and on the basis of the real images, learns a diagnosis method for the specific disease; an image collection unit that receives real images obtained by photographing peripheral parts of eyes of a person to be diagnosed; a disease diagnosis unit that determines whether the person being diagnosed has the specific disease, on the basis of learning data in the data storage unit and the received images in the image collection unit; and an output unit that displays, to the outside, a result of the determination from the disease diagnosis unit. Accordingly, disease diagnosis time and costs can be reduced, and disease can be diagnosed more easily.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/14 - Arrangements specially adapted for eye photography
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

Provided is a semiconductor-based DNA sensor which includes: a first electrode and a second electrode disposed on a substrate to be spaced apart from each other; a channel layer disposed between the first electrode and the second electrode; a target coupling layer disposed on the channel layer, and including probe DNA detecting target DNA through a hybridization reaction; a passivation layer selectively exposing an upper portion of the target coupling layer; and a gate layer disposed at a lower portion and/or an upper portion of the substrate, or an upper portion of the target coupling layer, in which the channel layer includes a metal oxide and a carbon nano tube.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• H01L 29/786 - Thin-film transistors

Abstract

The present invention relates to a gossip-based communication apparatus for decentralized distributed deep learning. The gossip-based communication apparatus for decentralized distributed deep learning, according to an embodiment of the present invention, comprises: a tensor control unit that merges respective layers into one tensor in segment-specific gossip communication; a segment communication unit that asynchronously communicates segments of a neural network model; and a topology control unit that generates a probability table for managing selection of peer worker nodes for inter-process communication in a network topology, wherein the tensor control unit may convert, into a non-flattened tensor, a tensor flattened after asynchronous communication is completed. This study was conducted as a result of the university ICT research center development support project of the Ministry of Science and ICT and the Institute for Information and Communication Technology Planning and Evaluation (IITP-2023-2018-0-01431).

IPC Classes  ?

• H04L 67/1042 - Peer-to-peer [P2P] networks using topology management mechanisms
• G06N 3/08 - Learning methods
• H04L 43/0852 - Delays

Abstract

A fault signal detection method includes acquiring decomposition signals according to a frequency band, by decomposing an original signal in the time domain into a certain number of frequency band signals, combining the certain number of decomposition signals and calculating a classification result value for classifying the original signal into a normal signal or a fault signal using a classification model using at least one decomposition signal included in a combination method as input and determining a combination method for detecting a fault signal based on classification result values of the classification model.

IPC Classes  ?

• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• G06F 18/2131 - Feature extraction, e.g. by transforming the feature spaceSummarisationMappings, e.g. subspace methods based on a transform domain processing, e.g. wavelet transform

Abstract

A domain adaptation device for longitudinal data includes a first module that generates first transformation data using a projection matrix for domain transformation and a graph matrix for data filtering, a second module that determines a domain of the first transformation data, and a third module that determines a label of the first transformation data.

IPC Classes  ?

• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

Disclosed is a learning method and device for alzheimer prediction model based on domain adaptation performed by at least one processor including extracting a point related to an object in a learning image from the learning image for a 3D reconstruction model, obtaining a gradient map including surrounding context information in three dimensions of the point from a 3D model of the object, determining a weight of the point based on the learning image and the gradient map, and learning the 3D reconstruction model by using the weight such that the 3D model of the object is output from the 3D reconstruction model into which the learning image is input.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A prospective classification device for predicting dementia that predicts a risk of a patient with mild cognitive impairment being converted to a dementia patient based on the characteristics of prognostic brain imaging data converted from a diagnostic brain imaging data and a method of operating the same are disclosed. The prospective classification device is configured to convert features of the diagnostic brain imaging data obtained at the time of diagnosis of a patient with mild cognitive impairment into features of prognostic brain imaging data corresponding to the prognostic time after the time of diagnosis using a prospective classification model.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a method for detecting and quantifying a target protease using a protease sensor for detecting a target protease and a pregnancy test strip on which an hCG antibody is immobilized, and to a kit for detecting a target protease comprising the protease sensor for detecting the target protease. According to the present invention, a target protease used as a biomarker for disease diagnosis can be easily detected and quantified with high sensitivity by using an existing commercially available pregnancy test strip.

IPC Classes  ?

• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

Disclosed is a plasma etching method. The plasma etching method may comprise: a first step for vaporizing liquid heptafluoroisopropyl methyl ether (HFE-347mmy) and liquid pentafluoropropanol (PFP); a second step for supplying discharge gas containing the vaporized HFE-347mmy and PFP and argon gas to a plasma chamber in which a to-be-etched object is placed; and a third step for discharging the discharge gas to generate plasma and etching the to-be-etched object using the plasma.

IPC Classes  ?

• H01L 21/311 - Etching the insulating layers
• H01J 37/32 - Gas-filled discharge tubes

Abstract

Provided is a composition for inhibiting anti-cancer drug resistance comprising a compound represented by Chemical Formula 1 below as an active ingredient: Provided is a composition for inhibiting anti-cancer drug resistance comprising a compound represented by Chemical Formula 1 below as an active ingredient: (wherein, R1 and R2 are each independently hydrogen, substitutable linear or branched C1-C12 alkyl, substitutable C3-C12 cycloalkyl, or substitutable C6-C18 aryl, R3 is carboxyl, hydroxyl, or acetyl, and the substitution is performed by oxygen, nitrogen, sulfur, linear or branched C1-C6 alkyl, C6-C20 aryl, halogen, or a combination thereof).

IPC Classes  ?

• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61P 35/00 - Antineoplastic agents

Abstract

366 in the solution.

IPC Classes  ?

• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 27/26 - Cyanides
• B01J 37/04 - Mixing
• B01J 37/08 - Heat treatment

Abstract

The present invention relates to a marker for diagnosing or monitoring osteosarcopenia, and use thereof. The present invention can provide the marker, which can be used in the diagnosis or monitoring of osteosarcopenia through a RNA sequencing (RNA-seq) technique, specifically, the maker being MMP2, MMP14, COL1A1, COL1A2 or COL3A1.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating immune dysregulation-related diseases, including oxidized immunoglobulin as an active ingredient and a preventive or therapeutic method using same, a pharmaceutical composition for treating allergic diseases, chronic inflammatory diseases, autoimmune diseases or malignant tumor diseases, including as an active ingredient oxidized immunoglobulin obtained through artificially induced oxidation; and a novel immunomodulatory therapy which, by administering the composition to patients with the diseases, is differentiated from existing immunoglobulin therapeutic agents and more effective.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• A61P 37/08 - Antiallergic agents
• C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum

Abstract

A transmission apparatus of a single carrier-based wireless communication system is proposed. The transmission apparatus may include a transceiver, a memory configured to store one or more instructions; and a processor configured to execute the one or more instructions stored in the memory. The processor may generate data symbols by modulating traffic data, generate a cyclic prefix (CP) on the basis of the data symbols, and generate a pilot symbol for the data symbol. The transceiver may transmit a single carrier frequency domain equalizer (SC-FDE) frame including the data symbol, the CP, and the pilot symbol. The data symbols may include first data symbols and second data symbols. The pilot symbol may be transmitted after transmission of the first data symbols and before transmission of the second data symbols.

IPC Classes  ?

• H04L 25/03 - Shaping networks in transmitter or receiver, e.g. adaptive shaping networks
• H04L 27/26 - Systems using multi-frequency codes

Abstract

The present invention relates to a nuclear reactor corium cooling apparatus for cooling, in a housed state, corium that leaks from a nuclear reactor, and provides the nuclear reactor corium cooling apparatus comprising: a cooling vessel which is disposed below the nuclear reactor and in which cooling fluid is stored; and phase-change heat diffusion plates which are provided in the cooling vessel and in which a working fluid is accommodated, wherein the phase-change heat diffusion plates, when coming into contact with the corium, conduct or phase-change heat-transfer the heat of the corium with the working fluid, so that the heat is dissipated with cooling fluid.

IPC Classes  ?

• G21C 15/18 - Emergency cooling arrangementsRemoving shut-down heat
• G21C 15/02 - Arrangement or disposition of passages in which heat is transferred to the coolant, e.g. for coolant circulation through the supports of the fuel elements

Abstract

Various embodiments of the present disclosure relate to a vehicle for avoiding collisions and a method of operating the vehicle. In an embodiment, a vehicle for avoiding a collision can include a plurality of sensors configured to obtain surrounding environment information and a processor operatively connected to the plurality of sensors. The processor can determine whether a line of a driving lane is at least partially detected based on line detection information included in the surrounding environment information, determine a maximum lateral movement distance for in-lane collision avoidance based on a position of the line when the line is at least partially detected, and determine the maximum lateral movement distance for in-lane collision avoidance based on a preset value when the line is not detected.

IPC Classes  ?

• B60W 30/09 - Taking automatic action to avoid collision, e.g. braking and steering
• B60W 30/095 - Predicting travel path or likelihood of collision
• B60W 40/072 - Curvature of the road
• B60W 40/076 - Slope angle of the road
• G08G 1/16 - Anti-collision systems

Abstract

An apparatus for predicting a collision of a vehicle with a surrounding object around the vehicle includes: a surrounding object information detection unit configured to obtain current state information on the object; a lane detection unit configured to obtain information on a lane on which the vehicle travels; a risk level determination unit configured to calculate a collision risk level between the object and the vehicle using state information on the object; a surrounding environment prediction unit configured to predict future state information on the object using an estimation algorithm or a deep learning algorithm; an information integration unit configured to integrate the current state information, the lane information, the collision risk level, and the future state information to generate a simplified bird's eye view; and a collision mode determination unit configured to predict collision modes by using the simplified bird's eye view.

IPC Classes  ?

• G06N 3/091 - Active learning
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06T 11/20 - Drawing from basic elements, e.g. lines or circles
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
• G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestriansRecognition of traffic objects, e.g. traffic signs, traffic lights or roads

Abstract

This system for providing a user experience design for a mobile application makes a detailed model in which human emotional factors are reflected according to the duration of application use on the basis of user experience elements of the mobile application, and uses the model to generate the user experience design for the mobile application, thereby enhancing functions of the mobile application. The present invention reflects, in application development, the detailed model in which human emotional factors are reflected according to the duration of application use on the basis of the user experience elements of the mobile application, so as to increase functional improvement, and thus can promote long-term use of the application.

IPC Classes  ?

• G06F 8/20 - Software design
• G06F 8/10 - Requirements analysisSpecification techniques
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
• G06F 40/30 - Semantic analysis
• G06F 16/93 - Document management systems
• G06Q 50/10 - Services

Abstract

A multiplayer game management system for promoting students' physical activities can increase the students' participation in a game by using, as a game goal achievement means, a physical activity task of performing exercise using unpowered means such as bicycling and walking, thereby increasing the students' physical activity and thus improving their health.

IPC Classes  ?

• A63F 13/65 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor automatically by game devices or servers from real world data, e.g. measurement in live racing competition
• A63F 13/45 - Controlling the progress of the video game
• A63F 13/212 - Input arrangements for video game devices characterised by their sensors, purposes or types using sensors worn by the player, e.g. for measuring heart beat or leg activity
• A63F 13/235 - Input arrangements for video game devices for interfacing with the game device, e.g. specific interfaces between game controller and console using a wireless connection, e.g. infrared or piconet
• A63F 13/35 - Details of game servers
• A63F 13/87 - Communicating with other players during game play, e.g. by e-mail or chat
• A63F 3/06 - Lottos or bingo gamesSystems, apparatus or devices for checking such games
• A63F 13/798 - Game security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for assessing skills or for ranking players, e.g. for generating a hall of fame
• A63F 13/795 - Game security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for finding other playersGame security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for building a teamGame security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for providing a buddy list
• H04W 4/12 - MessagingMailboxesAnnouncements

Abstract

The present invention provides a heat pipe sealing plug for sealing an inlet of a heat pipe having working fluid accommodated therein and a method for sealing a heat pipe by using same, the heat pipe sealing plug comprising: a plug body which is inserted into the inlet; and at least one discharge groove part which is provided at the outer surface of the plug body, surrounded by the heat pipe, wherein the discharge groove part is arranged in a part of the entire area of the plug body, surrounded by the heat pipe.

IPC Classes  ?

• F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes
• B23P 15/26 - Making specific metal objects by operations not covered by a single other subclass or a group in this subclass heat exchangers

Abstract

A network security situation assessment method of a network system includes: obtaining network traffic of the network system; detecting an attack on the network system from the obtained network traffic; identifying the detected attack; analyzing a possibility of an attack and an impact of an attack on the network system based on results of the detecting and identifying of the attack; and assessing a network situation of the network system based on a result of the analyzing, wherein the detecting of the attack on the network system includes detecting the attack from the network traffic using deep learning-based first model and second model.

IPC Classes  ?

• H04L 9/40 - Network security protocols

Abstract

Various embodiments of the present disclosure relate to a vehicle that includes a plurality of sensors configured to obtain surrounding environment information and a processor operatively coupled to the plurality of sensors. The processor is configured to generate a plurality of images reflecting dynamic characteristics according to a type of a surrounding object based on the surrounding environment information, and determine a collision avoidance trajectory for avoiding collision with the surrounding object based on the plurality of images reflecting dynamic characteristics according to the type of the surrounding object.

IPC Classes  ?

• G08G 1/16 - Anti-collision systems
• B60W 30/085 - Taking automatic action to adjust vehicle attitude in preparation for collision, e.g. braking for nose dropping
• B60W 30/095 - Predicting travel path or likelihood of collision
• B60W 50/00 - Details of control systems for road vehicle drive control not related to the control of a particular sub-unit
• B60W 50/14 - Means for informing the driver, warning the driver or prompting a driver intervention

Abstract

The present disclosure relates to handover in a communication system, and an operation method of a terminal may include the steps of: transmitting a measurement report to a first base station; receiving, from the first base station, a radio resource control (RRC) reconfiguration message including, as information about candidate base stations for the handover, at least one of information about a radio network temporary identifier (RNTI) of a second base station, information about a timing difference between the first base station and the second base station, and information about an uplink resource allocated by the second base station; and performing the handover to the second base station by using information included in the RRC reconfiguration message.

IPC Classes  ?

• H04W 36/00 - Handoff or reselecting arrangements
• H04W 36/32 - Reselection being triggered by specific parameters by location or mobility data, e.g. speed data
• H04W 36/30 - Reselection being triggered by specific parameters by measured or perceived connection quality data
• H04W 36/08 - Reselecting an access point
• H04W 36/36 - Reselection control by user or terminal equipment
• H04W 84/06 - Airborne or Satellite Networks
• H04W 36/18 - Performing reselection for specific purposes for allowing seamless reselection, e.g. soft reselection

Abstract

The present disclosure relates to beam selection in a system supporting satellite communication. A method for performing beam selection of a terminal in a communication system supporting satellite communication may comprise the steps of: receiving first information on an elevation angle and second information on the center of a beam for supporting the satellite communication; determining coverage of a beam on the basis of the first information and the second information; determining a distance between the terminal and the center of the beam on the basis of the second information; and selecting a serving beam for the terminal on the basis of the coverage of the beam and the distance.

IPC Classes  ?

• H04W 16/28 - Cell structures using beam steering
• H04W 48/10 - Access restriction or access information delivery, e.g. discovery data delivery using broadcasted information
• H04W 72/04 - Wireless resource allocation
• H04W 74/08 - Non-scheduled access, e.g. ALOHA
• H04B 7/185 - Space-based or airborne stations
• H04L 27/26 - Systems using multi-frequency codes
• H04W 84/06 - Airborne or Satellite Networks

Abstract

The present invention provides a sandblasting nozzle for in-pipe polishing, the sandblasting nozzle comprising: a nozzle body provided with a guide passage having an inlet and an outlet so as to discharge a spray material; a connection member provided on the nozzle body so as to be able to move back and forth in the same direction as the direction in which the spray material is discharged; and a spray control member provided on the connection member so as to be disposed at the outlet of the nozzle body and having a cross-sectional area that increases from the front to the rear in the direction in which the spray material is discharged. The spray control member is provided with at least one direct spray hole that passes therethrough in the same direction as the direction in which the spray material is discharged.

IPC Classes  ?

• B24C 3/12 - Apparatus using nozzles
• B24C 5/04 - Nozzles therefor
• B05B 12/08 - Arrangements for controlling deliveryArrangements for controlling the spray area responsive to condition of liquid or other fluent material discharged, of ambient medium or of target
• B05B 1/30 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages

Abstract

The present invention provides a heat pipe working fluid injection amount control device, comprising: a mounting frame that supports a heat pipe containing a working fluid so that the heat pipe can move vertically in an upright state; a heating part that heats the heat pipe; a static pressure support part that is connected to the lower end of the heat pipe and supports the heat pipe under a predetermined pressure condition; and a position checking part that is provided on the mounting frame and enables the vertical movement position of the heat pipe to be checked.

IPC Classes  ?

• F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes

Abstract

The present disclosure relates to a sleeve gastrectomy aid device including: a guide configured to be inserted into a stomach of a patient; an expander configured to be disposed outside the guide and have a volume that changes according to an amount of air therein; a first measurer configured to measure a pressure applied to the expander and have a shape that changes in accordance with a change in the volume of the expander; and a monitor configured to be connected to the first measurer and provide resection position information through a value of the pressure measured by the first measurer.

IPC Classes  ?

• A61F 5/00 - Orthopaedic methods or devices for non-surgical treatment of bones or jointsNursing devices
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/92 - Identification means for patients or instruments, e.g. tags coded with colour

Abstract

The present invention relates to a data collection and management apparatus for synchronizing an action of an avatar in a virtual reality, corresponding to a user, and an action of the user, the apparatus comprising: a first subordinate data management unit including a plurality of data management units that collect physical information by being respectively linked to sensors that are worn on body parts of the user to sense different types of the physical information, extract, from the physical information, physical data that is a data source required for synchronizing the avatar, and manage the physical data; a context data management unit that defines, as context data that is data for synchronizing the avatar, a common condition and a common method for enabling the plurality of data management units to extract the physical data under the same condition and method; and a VR generation unit that controls an action of the avatar on the basis of the context data. Accordingly, the context data can be easily integrated with various types of VR applications in a context recognition VR system.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
• G06Q 50/10 - Services
• G06V 40/18 - Eye characteristics, e.g. of the iris
• A61B 5/369 - Electroencephalography [EEG]
• A61B 5/389 - Electromyography [EMG]
• G02B 27/01 - Head-up displays
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present disclosure provides an acoustic metamaterial-based muffler for exhaust noise reduction, including an exhaust flow body that is provided with an inlet through which exhaust gas of an internal combustion engine flows in on one side, and an outlet through which the exhaust gas flows out on the other side, and a flow passage for guiding a movement of the exhaust gas therein; and a plurality of noise reduction units that are sequentially disposed along a discharge direction of the exhaust gas inside the exhaust flow body to reduce noise in a specific frequency band in exhaust noise of the exhaust gas caused by the movement of the exhaust gas on the inside of the exhaust flow body.

IPC Classes  ?

• F01N 1/24 - Silencing apparatus characterised by method of silencing by using sound-absorbing materials

Abstract

The present application pertains to a composite obtained by mixing a biodegradable glycerol carbonate derivative with a biodegradable polymer PLA using a plasticizer, the biodegradable glycerol carbonate derivative being prepared by reacting glycerol and dialkyl carbonate.

IPC Classes  ?

• C08K 5/1565 - Five-membered rings
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C07D 317/34 - Oxygen atoms