Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Goods & Services

Providing medical and scientific research information in the fields of pharmaceuticals and clinical trials; scientific research, biochemical research, and pharmaceutical research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases; scientific study and research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related disease; testing of pharmaceuticals; provision of pharmaceutical research information and chemical and biochemical analysis for research purposes. Provision of pharmaceutical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases.

Goods & Services

Providing temporary use of non-downloadable software for managing patient enrollment in clinical trials; Software as a service (SaaS) services featuring software for patient registration and data management in clinical studies; Providing an online platform for managing patient enrollment and participation in clinical trials; Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Medical services, namely, patient enrollment and management for clinical trials; Providing medical information to patients and healthcare professionals in the field of clinical trials; Consulting services in the field of patient recruitment for clinical trials; Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring medical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form

Goods & Services

(1) Providing medical and scientific research information in the fields of pharmaceuticals and clinical trials; scientific research, biochemical research, and pharmaceutical research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases; scientific study and research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related disease; testing of pharmaceuticals; provision of pharmaceutical research information and chemical and biochemical analysis for research purposes. (2) Provision of pharmaceutical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases.

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Packaged formulations of gamma-hydroxybutyrate having improved dissolution and chemical stability after storage for up to at least 72 months, packaging for supporting said stability, and therapeutic uses thereof.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61J 1/10 - Bag-type containers
• A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes - Details; Accessories therefor
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 47/02 - Inorganic compounds
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61K 47/38 - Cellulose; Derivatives thereof
• A61P 25/00 - Drugs for disorders of the nervous system

Goods & Services

Scientific and technological services, namely, scientific real world evidence studies and research in the fields of medicine, the prevention, treatment and management of illness, and health care delivery; Providing temporary use of non-downloadable software for collecting, analyzing, and reporting real-world evidence (RWE) data; Medical and scientific research in the field of pharmaceuticals and clinical trials; Medical and scientific research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Medical services, namely, conducting real-world evidence (RWE) studies; Providing medical information and data analysis in the field of pharmaceuticals and healthcare; Providing medical information and data analysis in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; Consulting services in the field of healthcare and pharmaceuticals; Providing a website featuring information about pharmaceuticals and participation in real-world evidence (RWE) studies; Providing a website featuring information about nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Goods & Services

Providing medical and scientific research information in the fields of pharmaceuticals and clinical trials; scientific research, biochemical research, and pharmaceutical research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases; scientific study and research in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related disease; testing of pharmaceuticals; provision of pharmaceutical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness, idiopathic hypersomnia, and other sleep related diseases; provision of pharmaceutical information in the fields of pharmaceutical research and chemical and biochemical analysis for research purposes

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, insomnia and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations for the treatment of central nervous system diseases and disorders; pharmaceutical preparations for the treatment of sleep disorders; pharmaceutical preparations for the treatment of narcolepsy, cataplexy, insomnia and other sleep related diseases; medications for central nervous system disorders and diseases and sleep disorders and diseases

Abstract

Oral pharmaceutical compositions of gamma-hydroxybutyrate (GHB) suitable for concomitant administration with a dose of divalproex sodium (DVP) without materially altering the dosage amount of either drug are provided. Also provided are therapeutic uses of the compositions for the treatment of one or more symptoms of narcolepsy.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/14 - Particulate form, e.g. powders

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/191 - Acyclic acids having two or more hydroxy groups, e.g. gluconic acid
• A61P 25/20 - Hypnotics; Sedatives

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/14 - Particulate form, e.g. powders

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/14 - Particulate form, e.g. powders

Goods & Services

Patient assistance programs, namely, business administration of prescription drug reimbursement programs Patient assistance programs, namely, providing financial assistance to pay prescription drug expenses, out-of-pocket expenses, and prescription co-pays

Goods & Services

Patient assistance programs, namely, business administration of prescription drug reimbursement programs Patient assistance programs, namely, providing financial assistance to pay prescription drug expenses, out-of-pocket expenses, and prescription co-pays

Goods & Services

Administration of a discount program for medical patients featuring product savings programs, product trial offers, and online tools to assist with obtaining prior authorizations and links to patient assistance programs which provide products to patients who are unable to afford the cost of their medication Charitable services, namely, patient assistance program to provide pharmaceuticals free of charge or at reduced cost to patients; providing information relating to diagnostic, prophylactic and therapeutics properties of pharmaceuticals; providing information to patients in the field of administering medications; Medical services, namely, providing information regarding medical conditions, treatment and products to patients and healthcare professionals; medical consultation, namely, providing advice to healthcare professionals and patients regarding medical conditions and treatment; providing a website featuring information about medical conditions and treatment; providing a website featuring information on medical practice management

Goods & Services

Administration of a program for enabling patients to obtain discounts on prescription drug spending through a copay discount program; administration of pharmacy reimbursement programs and co-pay support programs for patients; patient benefits programs in connection with pharmaceutical services Patient support and assistance in connection with pharmaceutical services, namely, providing information about eligibility for financial assistance provided through patient benefits programs

Goods & Services

Administration of a discount program for medical patients featuring product savings programs, product trial offers, and online tools to assist with obtaining prior authorizations and links to patient assistance programs which provide products to patients who are unable to afford the cost of their medication Charitable services, namely, patient assistance program to provide pharmaceuticals free of charge or at reduced cost to patients; providing information relating to diagnostic, prophylactic and therapeutics properties of pharmaceuticals; providing information to patients in the field of administering medications; Medical services, namely, providing information regarding medical conditions, treatment and products to patients and healthcare professionals; medical consultation, namely, providing advice to healthcare professionals and patients regarding medical conditions and treatment; providing a website featuring information about medical conditions and treatment; providing a website featuring information on medical practice management

Goods & Services

Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring medical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring medical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

Providing technical information in the field of pharmaceutical manufacturing in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases Pharmaceutical preparations and medications for use in the treatment of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases Provision of pharmaceutical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases Medical and pharmaceutical consultation in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; Providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Providing medical information to patients and medical professionals in the form of reports of in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

Providing online non-downloadable software enabling users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website. Provision of pharmaceutical information and advice relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website.

Goods & Services

Providing support services in the nature of medical information to physicians and patients regarding the recognition, screening, diagnosis, and management of narcolepsy and excessive sleepiness; medical information; providing medical information; providing medical information regarding the management of narcolepsy and excessive sleepiness

Goods & Services

Providing information featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website; providing information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website. Provision of pharmaceutical information and advice relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases.

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Abstract

Oral pharmaceutical compositions of gamma-hydroxybutyrate (GHB) suitable for concomitant administration with a dose of divalproex sodium (DVP) without materially altering the dosage amount of either drug are provided. Also provided are therapeutic uses of the compositions for the treatment of one or more symptoms of narcolepsy.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Oral pharmaceutical compositions of gamma-hydroxybutyrate (GHB) suitable for concomitant administration with a dose of divalproex sodium (DVP) without materially altering the dosage amount of either drug are provided. Also provided are therapeutic uses of the compositions for the treatment of one or more symptoms of narcolepsy.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Goods & Services

(1) Providing information featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases. (2) Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; Providing an interactive web site featuring information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases (3) Provision of pharmaceutical information and advice relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

(1) Providing online non-downloadable software enabling users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases via an interactive website. (2) Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases. (3) Providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases.

Goods & Services

Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring medical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Provision of medical information and advice in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice via a website in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of medical information and advice in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring medical information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Providing an interactive web site featuring technology that enables users to search, locate and access health care and medical service providers in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; providing an interactive web site featuring scientific research information in the fields of nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; provision of scientific information by means of an interactive web site in the field of pharmaceuticals relating to nervous system diseases and disorders, sleep disorders, narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, excessive daytime sleepiness and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases, namely, somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/14 - Particulate form, e.g. powders

Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Pharmaceutical compositions that include a bi-modal, mutiparticulate mixtures of immediate release particles and modified release particles to provide a therapeutic effect of methylphenidate, dexmethylphenidate, structural analogs of methylphenidate or dexmethylphenidate, pharmaceutical salts thereof, and mixtures thereof overextended periods of time.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 31/00 - Medicinal preparations containing organic active ingredients

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, insomnia and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases.

Goods & Services

(1) Pharmaceutical preparation acting on the central nervous system for treating somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, insomnia and other sleep related diseases; Medication for central nervous system disorders and diseases and sleep disorders and diseases, namely, somnipathy, chronic and acute fatigue, and sleep-wake cycle disorders.

Goods & Services

Pharmaceutical preparation acting on the central nervous system; pharmaceutical preparation for the treatment of central nervous system diseases and disorders; pharmaceutical preparation for the treatment of sleep disorders; pharmaceutical preparation for the treatment of narcolepsy, cataplexy, insomnia and other sleep related diseases; medication for central nervous system disorders and diseases and sleep disorders and diseases

Abstract

Packaged formulations of gamma-hydroxybutyrate having improved dissolution and chemical stability, packaging for supporting said stability, and therapeutic uses thereof.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Abstract

Packaged formulations of gamma-hydroxybutyrate having improved dissolution and chemical stability, packaging for supporting said stability, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61P 25/26 - Psychostimulants, e.g. nicotine, cocaine

Abstract

Packaged formulations of gamma-hydroxybutyrate having improved dissolution and chemical stability, packaging for supporting said stability, and therapeutic uses thereof.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers

Goods & Services

Orally administrable, microparticulate, pharmaceutical formulations in the nature of drug delivery agents that allow for the controlled release of one or more medicinal or nutritional active principles; orally administrable powders, suspensions, suspension powders, and capsules in the nature of drug delivery agents for providing the controlled release of one or more medicinal or nutritional active principles

Goods & Services

Medical and product research and development services notably in the field of microparticulate systems that allows for the controlled release of oral dosage formulations of drugs

Abstract

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

IPC Classes  ?

• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 31/19 - Carboxylic acids, e.g. valproic acid

Goods & Services

Providing medical information regarding pharmaceutical products in the nature of patient testimonials; providing information regarding sleep disorders, treatment, and recovery

Goods & Services

Providing online videos and other non-downloadable media, namely, audio recordings, video recordings, and video presentations featuring patient testimonials regarding sleep disorder treatments and medication; Providing online videos and other non-downloadable media, namely, audio recordings, video recordings, and video presentations in the field of sleep disorders, treatment, and recovery

Abstract

The invention relates to a pharmaceutical composition comprising a plurality of controlled-release coated microparticles each comprising a floating core, on the surface of which is deposited a layer containing at least one active principle, said layer being covered with a controlled-release coating, characterized by the fact that said floating core is composed of cellulose acetate phthalate and has an apparent density of less than or equal to 0.6 g/mL and said coated microparticles have a density of less than or equal to 0.7 g/mL.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/50 - Microcapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole

Goods & Services

Pharmaceutical preparations and medications for use in the treatment of hypotension in the setting of anesthesia; Pharmaceutical preparations and medications; Pharmaceutical products and preparations for the treatment of autoimmune diseases, bacterial infections, chronic anemia, hypotension, disorders of the musculo-skeletal system, for maintaining blood pressure, for the reversal of the effects of anesthesia, for the reversal of the effects of non-depolarizing neuromuscular blocking agents; chemical preparations for medical and veterinary purposes for injection or oral administration, namely, a drug delivery system in the form of coatings, tablets that provide continuous and controlled release of active ingredients in a wide variety of therapeutic agents to human patients; encapsulated pharmaceutical preparations for the prolonged and controlled release of active ingredients, for the treatment of a wide variety of diseases and disorders; injectable medication used to reverse anesthesia; medication used to maintain blood pressure. Provision of pharmaceutical information in the fields of pharmaceutical research and chemical and biochemical analysis. Provision of pharmaceutical information and advice.

Goods & Services

Pharmaceutical preparations and medications for use in the treatment of [ hypotension in the setting of anesthesia; pharmaceutical preparations and medications for treating pain management, respiratory diseases and disorders, allergic disorders, gastrointestinal disorders, ] sleep disorders [, dermatological conditions, pulmonary diseases, obstetrics and gynecology; pharmaceutical products, namely, pharmaceutical agents and preparations for the treatment of autoimmune diseases, bacterial infections, chronic anemia, hypotension, disorders of the musculo-skeletal system, for maintaining blood pressure, for the reversal of the effects of anesthesia, for the reversal of the effects of non-depolarizing neuromuscular blocking agents ] ; chemical preparations for medical [ and veterinary ] purposes for injection or oral administration, namely, a drug delivery system in the form of coatings, tablets that provide continuous and controlled release of active ingredients in a wide variety of therapeutic agents to human patients; drug delivery agents in the form of encapsulated pharmaceutical preparations for the prolonged and controlled release of active ingredients, for the treatment of a wide variety of diseases and disorders [ ; injectable medication used to reverse anesthesia; medication used to maintain blood pressure ] Provision of pharmaceutical information in the fields of pharmaceutical research and chemical and biochemical analysis for research purposes Provision of pharmaceutical advice; provision of pharmaceutical information, namely, the diagnostic, prophylactic and therapeutic properties of pharmaceuticals and instructional information for use of the pharmaceutical products

Abstract

The present invention provides stable pharmaceutical antibody formulations, including liquid formulations and lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific antibody, a polyaminoacid consisting of glutamic acid or aspartic acid or both randomly grafted with Vitamin E, and a cryoprotectant, wherein the formulation has a salt concentration of 50 m M or less. The present invention also provides stable pharmaceutical antibody formulations, including liquid formulations and lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific antibody, a polyaminoacid consisting of glutamic acid or aspartic acid or both randomly grafted with Vitamin E, a cryoprotectant, and a buffering system, wherein the pH of the formulation is about pH 7, and wherein the formulation has a salt concentration of 50 mM or less. The formulations may, optionally, further comprise a surfactant, or a stabilizing agent, or both. The present invention includes methods for making such formulations. The formulations can be used in the treatment of various diseases.

IPC Classes  ?

• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

Abstract

The present invention relates to an immediate-release oral form of at least one active compound, comprising coated particles formed of a non-monocrystalline core containing said active compound and coated with at least one coating layer, said coating layer comprising (A) at least 15% by weight of a water-insoluble polymer and (B) at least 40% by weight of a polymer soluble in a hydrochloric acid solution 0, 1N, the weighted ratio polymer B/polymer A being between 85/15 and 50/50, said coating layer representing at least 30% by weight of the total weight of said coated particles. It also relates to the use of such particles for preparing an immediate-release oral form of said active compound.

IPC Classes  ?

• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61K 9/50 - Microcapsules

Abstract

The invention relates to a pharmaceutical composition comprising a plurality of controlled-release coated microparticles each comprising a floating core, on the surface of which is deposited a layer containing at least one active principle, said layer being covered with a controlled-release coating, characterized by the fact that said floating core is composed of cellulose acetate phthalate and has an apparent density of less than or equal to 0.6 g/mL and said coated microparticles have a density of less than or equal to 0.7 g/mL.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• C08B 3/06 - Cellulose acetate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/50 - Microcapsules

Abstract

The invention relates to a pharmaceutical composition that includes a plurality of controlled-release coated microparticles, each comprising a floating core, at the surface of which a layer containing at least one active principle is deposited, said layer being covered by a controlled-release coating, characterized in that said floating core consists of cellulose phthalate acetate and has a bulk density of less than or equal to 0.6 g/mL, and in that said coated microparticles have a density of less than or equal to 0.7 g/mL.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/52 - Sustained or differential release type
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates