Abstract

Described here is a method to produce a chimeric protein having portions of yellow fever virus and dengue virus. A small portion of the yellow fever virus 17D vaccine strain envelope protein (or other related flavivirus) can be replaced by the corresponding portion from the dengue virus envelope protein. In some embodiments the chimeric protein may be used to create a treatment composition for DENV infection. In others, the chimeric protein may be used to create a vaccine that will induce broadly protective antibodies against dengue virus and reduce the induction of non-neutralizing antibodies that will cause enhancement.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 39/12 - Viral antigens
• C07K 14/18 - Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Methods for the production of photocatalytic materials and coated substrate materials are provided according to the invention. A process for forming a photocatalytic coating on a substrate is provided. The photocatalytic coating includes titanium oxide on a titanium substrate for example. The photocatalytic coated substrate may be used in a device for treating contaminated fluids including water, air and mixtures thereof.

IPC Classes  ?

• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/08 - Heat treatment
• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof

Abstract

A system and method for facilitating collaboration of a group. The system and method provide a ubiquitous anytime/everywhere environment realized through fixed and mobile technologies and scaffolded by group support software. The system includes a collaboration engine having an architecture that supports both generic collaborative processes along with task specific team processes instantiated through a sophisticated suite of advanced modular technologies. The collaboration engine drives dynamic and real time collaborative problem solving and decision making by integrating sensor and human data from the field with group support software that efficiently and effectively manages team interaction.

IPC Classes  ?

• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions
• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
• G06F 15/16 - Combinations of two or more digital computers each having at least an arithmetic unit, a program unit and a register, e.g. for a simultaneous processing of several programs

Abstract

Abstract The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

Abstract The invention relates chemical compound entry inhibitors and methods of determining such inhibitors that interact with regions of viruses, such as the dengue virus, as candidates for in vivo anti-viral compounds.

IPC Classes  ?

• C07C 57/44 - Cinnamic acid
• C07C 51/09 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid esters or lactones
• C07C 305/18 - Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings containing six-membered aromatic rings

Abstract

Methods to facilitate delivering of materials (120) into biological systems (110) using sonic energy (140). The processes include a method of controllably disrupting cell membranes and/or cell walls in biological cells (110) using sonic energy (140), methods of introducing materials (120) into biological cells (110) using sonic energy (140), and methods of correlating sonic energy exposure (140) to material transport efficiency into biological cells (110).

IPC Classes  ?

• B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor