Abstract

Systems and methods for retinal imaging are provided. A heads-up display (HUD) can be integrated with advanced retinal imaging modalities, including optical coherence tomography (OCT) and fundoscopy (e.g., fluorescence fundoscopy). The HUD can serve as a crucial component of this approach, offering several key functionalities (e.g., a fixation target and/or a means for dark adaptation).

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions

Abstract

The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
• A61K 31/433 - Thiadiazoles
• A61K 31/443 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61P 31/04 - Antibacterial agents

Abstract

Devices and methods for use in extraction procedures of analytes (organic and inorganic, including heavy metals) from matrices (e.g., complex matrices) in various fields (e.g., biological, clinical, chemical, environmental, toxicological, and forensic) are provided. The device can comprise a support structure acting as a rigid and stable support for extraction materials that can be inserted thereinto. The device can comprise a plurality of windows in the support structure through which the extraction materials can be exposed. The device can include two portions that can join together (e.g., using an interlocking system).

IPC Classes  ?

• G01N 1/34 - PurifyingCleaning
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

IPC Classes  ?

• C07D 277/42 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 25/16 - Anti-Parkinson drugs
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Systems and methods for providing a decentralized marketplace for patient-generated health data are provided. The systems and methods can store medical records on an interplanetary file system (IPFS) and blockchain, with the ability to encrypt and decrypt data on the IPFS and blockchain. This can securely associate and/or dissociate users from their “owned” property, securely transfer the ownership of records, securely share the records to other users, facilitate payment for nonfungible token (NFT) records, and/or facilitate transfers to aggregators of health records.

IPC Classes  ?

• G06Q 20/00 - Payment architectures, schemes or protocols
• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• G06Q 20/38 - Payment protocolsDetails thereof
• G06Q 20/40 - Authorisation, e.g. identification of payer or payee, verification of customer or shop credentialsReview and approval of payers, e.g. check of credit lines or negative lists
• H04L 9/08 - Key distribution

Abstract

Systems and methods for determining the yield stress of a non-Newtonian fluid in real time are provided. A pressure loss and/or liquid rise technique, an ultrasonic technique, and/or a penetrometer technique can be used to determine the yield stress of a non-Newtonian fluid. The ultrasonic technique can include a longitudinal wave approach and/or a shear wave approach. The methods and systems are non-invasive and only require slight modifications to the piping containing the non-Newtonian fluid in order to measure the yield stress.

IPC Classes  ?

• G01N 11/08 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture by measuring pressure required to produce a known flow
• G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties

Abstract

This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help prevent or reduce scar tissue growth in cardiovascular system and restore heart function. According to certain embodiments, a fluid-induced, pathological shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for preventing or reducing scar tissue growth in cardiovascular system. Therefore, compositions comprising the exosomes derived from stem cells and methods of preventing and/or treating scar tissue growth in cardiovascular system by administering the exosomes isolated from stem cells are also provided.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/18 - Growth factorsGrowth regulators
• A61K 38/19 - CytokinesLymphokinesInterferons
• A61K 38/20 - Interleukins
• A61K 38/22 - Hormones
• A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61K 38/38 - Albumins
• A61K 38/40 - Transferrins, e.g. lactoferrins, ovotransferrins
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

A method of treatment or prevention of HIV and other viral infection comprising the administration of a biopolymer-based hydrogel nanoparticles and/or microparticles. In preferred embodiments, the particles comprise chitosan, hydroxyethyl cellulose (HEC), and linseed oil polyol. These biopolymer-based hydrogel nanoparticles and/or microparticles are antiviral agents that can be employed alone or in combination with other drugs for treatment of the viral infection. Further, the pre-treatment with the particles is highly effective at inhibiting viruses. Therefore, this antiviral biopolymer-based hydrogel nanoparticles and/or microparticles may also be employed as a prophylactic.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/107 - Emulsions
• A61K 9/20 - Pills, lozenges or tablets

Abstract

This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

IPC Classes  ?

• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Devices and methods for nanofiber-based membrane fabrication are provided. Portable (e.g., handheld) electrostatic spinning or electrospinning devices can be used for nanofiber-based membrane fabrication (e.g., wound care films or membranes, such as cannabidiol (CBD)-loaded films or membranes) and can be wearable and/or ultralow power. The device can include a needleless spinneret having solution supplied thereto and all powered by a low voltage battery.

IPC Classes  ?

• D01D 5/00 - Formation of filaments, threads, or the like
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• D01D 4/02 - Spinnerettes

Abstract

Erosion test rigs are provided for propelling dust and/or particles at high velocity and providing variable temperature ranges, as well as methods of using and fabricating the same. The erosion test rig can propel dust and/or particles at a velocity of up to 400 meters per second (m/s) and generate wide temperature ranges (e.g., from −196° C. to 200° C.) to simulate the harsh erosive conditions of planetary environments (e.g., Mars and Luna).

IPC Classes  ?

• G01N 3/56 - Investigating resistance to wear or abrasion
• G01N 3/06 - Special adaptations of indicating or recording means

Abstract

Systems and methods for wireless simultaneous transmit and receive (STAR) using multi-input multi-output (MIMO) radiofrequency (RF) front-ends are provided. A MIMO front-end can be based on the use of a symmetrical pair of arrays, in which one is used for communication while the other is used inside an RF-shielded chamber to act as a reference for subtracting self-interference between transmitters and receivers. In addition to the two arrays, the system can include two identical passive microwave multi-beam beamforming networks. The beamformer networks can be, for example, Butler Matrix based, true-time delay microwave networks, or Rotman lens based.

IPC Classes  ?

• H04B 7/04 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H04B 1/16 - Circuits
• H04B 1/40 - Circuits
• H04B 7/0426 - Power distribution

Abstract

The subject invention provides a novel fluorescence-based, T5 exonuclease-amplified DNA cleavage assay for gyrase poisoning inhibitor discovery. According to the assay, multiple gyrase molecules can simultaneously bind to a plasmid DNA molecule to form multiple gyrase-DNA cleavage complexes on the same plasmid. These gyrase-DNA cleavage complexes, greatly stabilized by a gyrase poisoning inhibitor, and can be trapped by a detergent such as sarkosyl. Digestion of gyrase by proteinase K results in the production of small DNA fragments, which can be digested by T5 exonuclease. This fluorescence-based DNA cleavage HTS assay is also suitable for screening large compound libraries to identify inhibitors against DNA topoisomerases, including human DNA topoisomerase IIα.

IPC Classes  ?

• C12Q 1/682 - Signal amplification
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C12Q 1/533 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving isomerase
• C12Q 1/6832 - Enhancement of hybridisation reaction

Abstract

Additive-polymer precursor materials for filaments (e.g., for three-dimensional (3D) printing) are provided, as well as methods of fabricating and using the same. One or more two-dimensional (2D) additive materials (e.g., nano materials, such as nanosheets) can be mixed with a polymer base to give an additive-polymer precursor composite material. The additive material can be dissolved in a first solvent to give an additive solution, and the polymer can be dissolved in a second solvent to give a polymer base. The additive solution can be mixed with the polymer base to give a mixed solution. Solvent casting can then be performed on the mixed solution to evaporate the solvent(s) and give the additive-polymer precursor composite material, which can have a layered structure.

IPC Classes  ?

• C08K 3/11 - Compounds containing metals of Groups 4 to 10 or of Groups 14 to 16 of the Periodic Table
• B29C 48/14 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds

Abstract

Systems and methods for detecting unrestricted file upload (UFU) vulnerabilities in Node.js (e.g., Node.js web applications) are provided. A lightweight framework can be used, drawing on a comprehensive evaluation of unique UFU-type attack types from multiple sources. By tailoring these attack instances to the Node.js ecosystem, systems and methods of embodiments of the subject invention offer more thorough coverage of potential attack vectors than existing technologies and tools.

IPC Classes  ?

• G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities

Abstract

Cold-sprayed aluminum capacitors on lead frame metal foils are provided for applications in 3D power package integration. This additive manufacturing process allows pre-patterned low-temperature processing of aluminum electrodes on metal lead frames, insulated metal substrates or even heat-spreaders and cold-plates. Cold-sprayed capacitors can eliminate several process integration and reliability issues that are associated with traditional discrete surface-assembled capacitors.

IPC Classes  ?

• H01G 13/00 - Apparatus specially adapted for manufacturing capacitorsProcesses specially adapted for manufacturing capacitors not provided for in groups
• H01G 4/008 - Selection of materials
• H01G 4/04 - Liquid dielectrics
• H01G 4/224 - HousingEncapsulation
• H01G 4/228 - Terminals

Abstract

Ultra-wideband (UWB) arrays that are fully planar are provided. Fully-planar inverted-L element (FILE) arrays that are tightly coupled arrays (TCAs) can realize UWB tightly coupled apertures in the W and higher millimeter wave (mmWave) bands. The unit cell architecture of the FILE array, (which can have any desired size, can be comprised of an inverted-L shaped antenna and a capacitively coupled via-fence.

IPC Classes  ?

• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
• H01Q 1/40 - Radiating elements coated with, or embedded in, protective material
• H01Q 5/25 - Ultra-wideband [UWB] systems, e.g. multiple resonance systemsPulse systems
• H01Q 9/42 - Resonant antennas with feed to end of elongated active element, e.g. unipole with folded element, the folded parts being spaced apart a small fraction of the operating wavelength
• H01Q 21/00 - Antenna arrays or systems

Abstract

The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).

IPC Classes  ?

• A61K 31/765 - Polymers containing oxygen
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61K 9/107 - Emulsions
• A61K 36/55 - Linaceae (Flax family), e.g. Linum
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 49/00 - Preparations for testing in vivo
• A61P 35/00 - Antineoplastic agents

Abstract

Systems and methods are provided for assisting individuals with physical and/or cognitive ailments, such as dementia, Alzheimer's disease, and/or visual impairment. The quality of life, safety, and/or autonomy of such individuals can be enhanced by utilizing a combination of sensors, actuators, augmented reality (AR) technology, and machine learning (ML) algorithms. The sensors and actuators can include (but are not limited to) cameras, global positioning system (GPS) sensors, accelerometers, motion sensors, AR visual systems, headphones, microphones, haptic feedback systems, and/or connectivity capabilities (wired and/or wireless) to provide information about the surrounding environment and events. By leveraging advanced sensor technology, AR, and real-time data processing, a comprehensive support system can be provided that addresses the unique challenges faced by these individuals on a daily basis.

IPC Classes  ?

• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• G06F 1/16 - Constructional details or arrangements
• G06Q 40/08 - Insurance
• G06V 20/20 - ScenesScene-specific elements in augmented reality scenes
• G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance

Abstract

The present invention provides materials, devices and methods for detecting, determining, monitoring and/or extracting one or more metals such as cadmium, lead, copper, chromium, cobalt, nickel, zinc, manganese, mercury, vanadium, arsenic, and silver in fluid samples. The present invention also provides formulations and methods for synthesizing a metal-extracting materials comprising a pyridylethylthiopropyl functionalized sol-gel silica-based sorbent.

IPC Classes  ?

• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01D 15/02 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor with moving adsorbents
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/30 - Processes for preparing, regenerating or reactivating

Abstract

The subject invention provides multi-species reference ladders, multiplex PCR kits, and methods for multi-species identification using the multi-species reference ladders and multiplex PCR kits. Advantageously, the multi-species reference ladder and multiplex kit allows for a stream-lined analysis process and rapid species identification in a single test.

IPC Classes  ?

• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided. Results show that an enhanced sensitivity and higher current output can be achieved by a lower spatial density configuration of three micro-features per millimeter length, a smaller feature size of around 100 μm, and a 60-50 degrees pyramid angle.

IPC Classes  ?

• G01L 1/18 - Measuring force or stress, in general using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Hybrid carbon nanofiber (Cnf) products (e.g., mats, yarns, webs, etc.) and methods of fabricating the same are provided. The hybrid Cnf products are flexible and lightweight and have high thermal conductivity. An electrospinning process can be used to fabricate the hybrid Cnf products and can include preparation of an electrospinning solution, electrospinning, and carbonization (e.g., under a vacuum condition).

IPC Classes  ?

• D01F 9/22 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyacrylonitriles
• C08J 3/20 - Compounding polymers with additives, e.g. colouring
• C08J 3/21 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase the polymer being premixed with a liquid phase
• C09K 5/14 - Solid materials, e.g. powdery or granular
• D01D 1/02 - Preparation of spinning solutions
• D01D 5/00 - Formation of filaments, threads, or the like
• D01F 1/10 - Other agents for modifying properties
• D01F 9/24 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• D04H 3/007 - Addition polymers
• D04H 3/03 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments at random
• D06C 7/04 - Carbonising or oxidising

Abstract

Systems and methods are provided for color-coded visualization to aid in diagnosis and prognosis of Alzheimer's disease (AD). The color-coded visualization mechanism can be driven by an integrated machine learning (ML) model, which can take as its inputs neuroimaging (e.g., magnetic resonance imaging (MRI), positron emission tomography (PET)) data, neuropsychological test scores, the cerebrospinal fluid (CSF) biomarker, and/or risk factors. With these inputs, the ML model can generate a color-coded visualization of the disease state.

IPC Classes  ?

• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• G06T 7/00 - Image analysis
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Cold-sprayed aluminum capacitors on lead frame metal foils are provided for applications in 3D power package integration. This additive manufacturing process allows pre-patterned low-temperature processing of aluminum electrodes on metal lead frames, insulated metal substrates or even heat-spreaders and cold-plates. Cold-sprayed capacitors can eliminate several process integration and reliability issues that are associated with traditional discrete surface-assembled capacitors.

IPC Classes  ?

• H01G 13/00 - Apparatus specially adapted for manufacturing capacitorsProcesses specially adapted for manufacturing capacitors not provided for in groups
• H01G 4/008 - Selection of materials
• H01G 4/04 - Liquid dielectrics
• H01G 4/224 - HousingEncapsulation
• H01G 4/228 - Terminals

Abstract

Dual-polarized ultrawideband antennas and antenna arrays are provided. Fully inverted-L elements (FILEs) can be used as the radiating element in a unit cell antenna, which can be repeated to form an array. The dual-polarized FILE unit cell can include two L-bent elements, which tightly couple to a common shorted via as well as to each other. The same shorted via can be utilized to suppress the well-known common mode resonance.

IPC Classes  ?

• H01Q 9/04 - Resonant antennas
• H01Q 1/48 - Earthing meansEarth screensCounterpoises
• H01Q 5/25 - Ultra-wideband [UWB] systems, e.g. multiple resonance systemsPulse systems
• H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction

Abstract

Systems, devices, and methods for performing peripheral vascular imaging are provided. A continuous wave, non-contact, near-infrared optical scanner (NIROS) can utilize at least one near-infrared (NIR) light. The diffuse reflected NIR signal(s) can be obtained from the surface of the tissue of the mammal being imaged. The signal(s) can be optically filtered and can be detected by an NIR-sensitive image sensor. A graphical user interface (GUI) can be used to automate the acquisition of the spatio-temporal diffuse reflected maps from the NIROS device.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The subject invention provides compositions and methods for isolating exosomes from, for example, biological fluid samples, cell cultures and/or cultured medium. Provided are Absolute Precipitation of Exosomes (APEX) reagents and precipitation techniques to isolate exosomes from various EV subsets, cells, dead cells, and/or cell debris. Advantageously, APEX is a rapid, effortless, inexpensive, high-recovery method to extract exosomes. This method is also faster and purer at isolating exosomes from other precipitation techniques.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The present disclosure relates to nanoparticle compositions and uses thereof for treating or preventing HIV infection.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/4433 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/499 - Spiro-condensed pyrazines or piperazines
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/536 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
• A61K 31/5365 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/537 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/69 - Boron compounds
• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/18 - Growth factorsGrowth regulators
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

Systems and methods for evaluating historical trends in real estate prices are provided. Systems and methods provide an understanding of historical price trends and assist in a property evaluation or appraisal, as well as allowing for an analysis of comparables in estimating a reasonable offer for a property on the market. Given a timespan of interest, a locale, and a category of properties of interest, an objective historical trend in values can be computed by first evaluating the ratios between the realized prices of transactions and objective governmental assessment of the properties at some fixed point of time. Then, for each period the ratios of all transactions in that period can be averaged, followed by comparing said averages between different time periods.

IPC Classes  ?

• G06Q 30/0202 - Market predictions or forecasting for commercial activities
• G06Q 50/16 - Real estate

Abstract

Systems and methods for the control and operation of a grid-connected converter with an energy storage system are provided. The system can include a small microgrid comprising an AC grid that is feeding a DC load through a converter. The converter is connected to the AC grid through an R-L filter. The classical linear controllers have limitations due to their slow transient performance and low robustness against parameter variations and load disturbances. In certain embodiments, the transient and steady state responses of the provided artificial intelligence based Robust Artificial Neural Network Tracking Control (RANNTC) of three-phase grid-connected power converters has been shown to be more enhanced in terms of overshoot (24% lower), settling time (85% reduced), and total harmonic distortion (THD) (55% lower).

IPC Classes  ?

• H02M 7/217 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
• G06N 3/045 - Combinations of networks
• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers

Abstract

The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided. Results show that an enhanced sensitivity and higher current output can be achieved by a lower spatial density configuration of three micro-features per millimeter length, a smaller feature size of around 100 μm, and a 60-50 degrees pyramid angle.

IPC Classes  ?

• G01L 1/18 - Measuring force or stress, in general using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

IPC Classes  ?

• C07D 277/42 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 25/16 - Anti-Parkinson drugs
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Systems and methods for wireless simultaneous transmit and receive (STAR) using multi-input multi-output (MIMO) radiofrequency (RF) front-ends are provided. A MIMO front-end can be based on the use of a symmetrical pair of arrays, in which one is used for communication while the other is used inside an RF-shielded chamber to act as a reference for subtracting self-interference between transmitters and receivers. In addition to the two arrays, the symmetry of the system can include two identical passive microwave multi-beam beamforming networks. The beamformer networks can be, for example, Butler Matrix based, true-time delay microwave networks, or Rotman lens based.

IPC Classes  ?

• H04B 7/04 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H04B 1/16 - Circuits
• H04B 1/40 - Circuits
• H04B 7/0426 - Power distribution

Abstract

Provided is a method of repairing structures on the Lunar surface using Lunar regolith containing metallic coatings. An ultra-portable and low-pressure cold spray system is utilized to consolidate coatings. This system can be easily transported to space, reducing the payload. Lunar regolith is added to the metal powder before cold spray deposition. Lunar regolith increases the tampering effect during cold spray deposition, thereby causing severe plastic deformation of the metal powders and providing a coating with high quality and minimum porosity. The presence of Lunar regolith increases the hardness of the coating and improves wear properties. Coatings on a large area can be made rapidly without much surface preparation. These coatings can be rapidly applied to various Lunar structures to repair, reinforce, and restore (RRR) functionality and performance in the Lunar environment.

IPC Classes  ?

• C23C 24/04 - Impact or kinetic deposition of particles

Abstract

Stacked magnetic cores that can achieve high density with a small footprint are provided. A stacked magnetic core can include a plurality of magnetic films with an adhesive film between each magnetic film and the adjacent magnetic film(s). That is, the magnetic films and adhesive films can be disposed in an alternating fashion. Each adhesive film can be a dielectric/insulating film such that each magnetic film is electrically insulated from every other magnetic film.

IPC Classes  ?

• H01F 27/245 - Magnetic cores made from sheets, e.g. grain-oriented
• H01F 3/02 - Cores, yokes or armatures made from sheets
• H01F 27/28 - CoilsWindingsConductive connections

Abstract

Systems and methods for imaging breath-hold (BH)-induced oxygenation changes in a patient are provided. A non-invasive, non-contact device can be used to image BH-induced oxygenation changes in one or more parts (e.g., foot) of a patient. The patient can hold his or her breath for a set amount of time while imaging is performed using the device, and the imaging can be performed before and/or after the time while the patient is holding his or her breath as well (e.g., during a recovery period). This enables tissue oxygenation based flow correlation independent of melanin concentration (e.g., skin color) of the patient and/or the curvature of the tissue (of the patient) being imaged.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• G06T 7/00 - Image analysis

Abstract

Ultrawideband (UWB) beamforming networks are provided. A UWB beamforming network can have azimuth angle scanning and elevation angle scanning. A modified version of the Blass matrix topology can be used to achieve two-dimensional (2D) scanning behavior. The beamforming network can simultaneously excite a plurality of beams, and each of these beams can be at any chosen frequency inside the bandwidth that the beamformer covers. Each beam can be designed to point at any arbitrary direction, which can be defined by the desired elevation angle and azimuth angle, in the 2D plane.

IPC Classes  ?

• H01Q 3/40 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with phasing matrix
• H01Q 3/26 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture
• H01Q 3/30 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase
• H01Q 3/34 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means
• H01Q 21/00 - Antenna arrays or systems
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

2Cl, which exhibits superior performance compared to other analogs.

IPC Classes  ?

• C07F 9/00 - Compounds containing elements of Groups 5 or 15 of the Periodic Table

Abstract

Antenna arrays with three-dimensional (3D) conformal radiating elements are provided, as well as methods of manufacturing and methods of using the same. An array can include a ground plane and a plurality of unit cells disposed thereon. Each unit cell can include a 3D conformal radiating element. The 3D conformal radiating elements can be, for example, patches (e.g., circular 3D patches), dipoles, or loops, and each radiating element is conformal on a hemispherical shape.

IPC Classes  ?

• H01Q 5/48 - Combinations of two or more dipole type antennas
• H01Q 3/46 - Active lenses or reflecting arrays
• H01Q 15/04 - Refracting or diffracting devices, e.g. lens, prism comprising wave-guiding channel or channels bounded by effective conductive surfaces substantially perpendicular to the electric vector of the wave, e.g. parallel-plate waveguide lens
• H01Q 21/00 - Antenna arrays or systems
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
• H01Q 21/20 - Arrays of individually energised antenna units similarly polarised and spaced apart the units being spaced along, or adjacent to, a curvilinear path
• H01Q 21/26 - Turnstile or like antennas comprising arrangements of three or more elongated elements disposed radially and symmetrically in a horizontal plane about a common centre

Abstract

Ultra-wideband (UWB) arrays that are fully planar are provided. Fully-planar inverted-L element (FILE) arrays that are tightly coupled arrays (TCAs) can realize UWB tightly coupled apertures in the W and higher millimeter wave (mmWave) bands. The unit cell architecture of the FILE array, (which can have any desired size, can be comprised of an inverted-L shaped antenna and a capacitively coupled via-fence.

IPC Classes  ?

• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
• H01Q 1/40 - Radiating elements coated with, or embedded in, protective material
• H01Q 5/25 - Ultra-wideband [UWB] systems, e.g. multiple resonance systemsPulse systems
• H01Q 9/42 - Resonant antennas with feed to end of elongated active element, e.g. unipole with folded element, the folded parts being spaced apart a small fraction of the operating wavelength
• H01Q 21/00 - Antenna arrays or systems

Abstract

Multi-band, microstrip patch antennas, as well as methods of fabricating the same and methods of using the same, are provided. A decoupling technique can be used where strategically etched slots are provided between the tightly coupled microstrip patch antennas, and the appropriate mode excitation of the corresponding patch antennas can be used. The antennas have high isolation between the frequency bands of operation. Multi-band operation can be achieved by exciting a different mode on each contiguous portion of the patch antenna.

IPC Classes  ?

• H01Q 9/04 - Resonant antennas
• H01Q 5/378 - Combination of fed elements with parasitic elements

Abstract

The present invention is directed to compounds which have been identified, as inhibitors of the expression of CDR1 (Cdr1p) and/or CDR2 (Cdr2p), both ABC-type plasma, membrane transporters, which are major contributor to antifungal therapy resistance. These compounds may be used in the treatment of fungal infections, especially Candida infections, either alone or in combination with azole antifungal agents such as fluconazole, itraconazole, miconazole, clotrimazole and the like. Often the inhibitor compounds described herein are useful for reversing the antifungal therapy resistance exhibited by the overexpression of CDR1 and/or CDR2 in strains of fungi, especially including Candida spp. Combination therapy and compositions for treating fungal infections, especially including azole resistant fungal infections represent important embodiments of the present invention.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/13 - Amines, e.g. amantadine
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61P 31/10 - Antimycotics

Abstract

Provided are compositions and methods for specific fucosyltransferase inhibition for treatment of a variety of diseases. The compositions of the invention comprise a glycomimetic of L-Fucose that selectively inhibits the generation of sialyl Lewis X by FTVI and FTVH but has no effect on the generation of Lewis X by FTIX.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• A61K 31/13 - Amines, e.g. amantadine
• A61K 31/66 - Phosphorus compounds
• A61K 31/33 - Heterocyclic compounds

Abstract

Methods and polymethine bridge-containing cyanine compositions for inhibiting topoisomerase III beta (TOP3B), RNA-dependent RNA polymerases, and RNA-dependent DNA polymerases and conferring antiviral and/or anti-cancer activity are disclosed.

IPC Classes  ?

• C09B 23/00 - Methine or polymethine dyes, e.g. cyanine dyes
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Systems and methods are provided for color-coded visualization to aid in diagnosis and prognosis of Alzheimer's disease (AD). The color-coded visualization mechanism can be driven by an integrated machine learning (ML) model, which can take as its inputs neuroimaging (e.g., magnetic resonance imaging (MRI), positron emission tomography (PET)) data, neuropsychological test scores, the cerebrospinal fluid (CSF) biomarker, and/or risk factors. With these inputs, the ML model can generate a color-coded visualization of the disease state.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.

IPC Classes  ?

• A61K 8/43 - Guanidines
• A61K 31/133 - Amines, e.g. amantadine having hydroxy groups, e.g. sphingosine
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 31/04 - Antibacterial agents
• A61P 31/06 - Antibacterial agents for tuberculosis
• C07C 279/12 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
• C07D 295/215 - Radicals derived from nitrogen analogues of carbonic acid
• C08G 65/00 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
• C08G 71/02 - Polyureas

Abstract

Systems, devices, and methods for implanting target-specific multiple intrafascicular electrodes in peripheral nerves are provided to facilitate an implantation process that can reduce the difficulty of the implanting procedure and the time taken to implement the procedure. A longitudinal intrafascicular electrode implantation facilitator (LIFT) and a method for utilization of the LIFT for intrafascicular electrode implantation are provided. The LIFT can flatten the nerve to increase access to the number of fascicles available for implantation and supports the nerve during electrode implantation.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/28 - Surgical forceps

Abstract

A method, which synthesizes closed circular single-stranded and double-stranded DNA molecules using in vitro enzymatic systems, is described. Circular single-stranded DNA molecules and double-stranded DNA molecules (e.g., relaxed, or supercoiled) with various sizes can be synthesized. Unwanted DNA molecules, e.g., unligated oligomers, can be removed by exonucleases, such as T5 exonuclease, T7 exonuclease, lambda exonuclease, E. coli exonuclease I and/or III. A method of converting the single-stranded circular DNA molecules into double-stranded circular DNA molecules is also described. The single-stranded and double-stranded circular DNA molecules can be used in a variety of applications.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).

IPC Classes  ?

• A61K 31/765 - Polymers containing oxygen
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61K 9/107 - Emulsions
• A61K 36/55 - Linaceae (Flax family), e.g. Linum
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 49/00 - Preparations for testing in vivo
• A61P 35/00 - Antineoplastic agents

Abstract

Lithium-sulfur battery cathodes with a graded structure are provided and can include an actively electro-catalyzing and polysulfide-trapping system to improve sulfur utilization and capacity retention, as well as methods of fabricating the same and methods of using the same. The graded structure Li—S cathode can be prepared using economic and scalable synthesis and coating methods.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/04 - Processes of manufacture in general
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators

Abstract

Lithium-sulfur battery cathodes with a graded structure are provided and can include an actively electro-catalyzing and polysulfide-trapping system to improve sulfur utilization and capacity retention, as well as methods of fabricating the same and methods of using the same. The graded structure Li-S cathode can be prepared using economic and scalable synthesis and coating methods.

IPC Classes  ?

• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/1397 - Processes of manufacture of electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 10/052 - Li-accumulators
• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx

Abstract

Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.

IPC Classes  ?

• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 1/054 - Nanosized particles
• B22F 1/103 - Metallic powder containing lubricating or binding agentsMetallic powder containing organic material containing an organic binding agent comprising a mixture of, or obtained by reaction of, two or more components other than a solvent or a lubricating agent
• B22F 10/64 - Treatment of workpieces or articles after build-up by thermal means
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C22C 21/00 - Alloys based on aluminium

Abstract

Additive-polymer precursor materials for filaments (e.g., for three-dimensional (3D) printing) are provided, as well as methods of fabricating and using the same. One or more two-dimensional (2D) additive materials (e.g., nano materials, such as nanosheets) can be mixed with a polymer base to give an additive-polymer precursor composite material. The additive material can be dissolved in a first solvent to give an additive solution, and the polymer can be dissolved in a second solvent to give a polymer base. The additive solution can be mixed with the polymer base to give a mixed solution. Solvent casting can then be performed on the mixed solution to evaporate the solvent(s) and give the additive-polymer precursor composite material, which can have a layered structure.

IPC Classes  ?

• C08K 3/11 - Compounds containing metals of Groups 4 to 10 or of Groups 14 to 16 of the Periodic Table
• B29C 48/14 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds

Abstract

Solid-state electrolytes for use in lithium-ion (Li-ion) batteries, as well as methods of synthesizing the same, methods of preparing the same into a film, and methods of using the same in a Li-ion battery, are provided. Solid-state electrolyte pellets can be prepared in a solution, and a film using the synthesized pellet can be formed and used in a Li-ion battery.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
• C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 50/451 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising layers of only organic material and layers containing inorganic material

Abstract

Devices and methods for use in extraction procedures of analytes (organic and inorganic, including heavy metals) from matrices (e.g., complex matrices) in various fields (e.g., biological, clinical, chemical, environmental, toxicological, and forensic) are provided. The device can comprise a support structure acting as a rigid and stable support for extraction materials that can be inserted thereinto. The device can comprise a plurality of windows in the support structure through which the extraction materials can be exposed. The device can include two portions that can join together (e.g., using an interlocking system).

IPC Classes  ?

• G01N 1/34 - PurifyingCleaning
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

Electrolytes for improved electrochemical batteries are provided. A carbonate-based electrolyte can include a thioamide compound (e.g., thioacetamide (TAA), thiourea (THU), or thioformamide). The electrolyte can include a salt, a carbonate solvent, and the thioamide compound as an additive. The thioamide compound can be present in a concentration of, for example, 1 millimolar (mM) to 100 mM.

IPC Classes  ?

• H01M 10/0567 - Liquid materials characterised by the additives
• C08K 5/405 - ThioureasDerivatives thereof
• H01M 6/16 - Cells with non-aqueous electrolyte with organic electrolyte

Abstract

Systems and methods are provided to simulate, approximate, or replicate conditions similar to concrete elements being placed under pressures equivalent to several hundred feet of ocean water and to provide information useful to assess relative durability of concrete without coring or other destructive actions. The quality of concrete can be assessed by measuring the pressure drop of water or other liquid to ingress through the concrete surface under high pressure over time. A rapid assessment of quality of existing concrete is provided. Systems and methods can efficiently assess long term durability of existing concrete elements such as those used in midrise buildings, parking garages, bridge decks, and the like.

IPC Classes  ?

• G01N 33/38 - ConcreteLimeMortarGypsumBricksCeramicsGlass
• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 3/12 - Pressure-testing

Abstract

Systems and methods for real-time continuous monitoring of fuel cell membrane degradation are provided. At least one microsensor can be used as an inline sensor integrated at the cathode exhaust and/or the anode exhaust of a fuel cell, such as a proton exchange membrane fuel cell (PEMFC)). The microsensor can monitor the PEMFC degradation status by sensing the emission of fluoride.

IPC Classes  ?

• H01M 8/04 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids
• H01M 8/04664 - Failure or abnormal function
• H01M 8/04992 - Processes for controlling fuel cells or fuel cell systems characterised by the implementation of mathematical or computational algorithms, e.g. feedback control loops, fuzzy logic, neural networks or artificial intelligence

Abstract

Electrolytes for improved electrochemical batteries are provided. A carbonate-based electrolyte can include a thioamide compound (e.g., thioacetamide (TAA), thiourea (THU), or thioformamide). The electrolyte can include a salt, a carbonate solvent, and the thioamide compound as an additive. The thioamide compound can be present in a concentration of, for example, 1 millimolar (mM) to 100 mM.

IPC Classes  ?

• H01M 10/0569 - Liquid materials characterised by the solvents
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 50/417 - Polyolefins
• H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes

Abstract

2Cl, which exhibits superior performance compared to other analogs.

IPC Classes  ?

• C07F 9/00 - Compounds containing elements of Groups 5 or 15 of the Periodic Table

Abstract

Systems and methods are provided for combined inductive power transfer (IPT) and capacitive power transfer (CPT) to reduce power pulsation in dynamic charging of electric vehicles. Aluminum plates provided between transmitter coils inhibit output power drop, the power pulsation can be reduced, and a constant power profile is provided by operation of CPT system when the receiver is between the IPT coils. As the aluminum plates cover the space between coils, the IPT coils can be separated away from each other by a longer distance compared to conventional segmented coils; therefore, a lesser copper can be used which enhances the cost effectiveness of the provided system. As the respective IPT and CPT system are used alternatively, thus the system's output power can be constant, nearly constant, or effectively constant.

IPC Classes  ?

• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• B60L 53/12 - Inductive energy transfer
• B60L 53/30 - Constructional details of charging stations
• H02J 50/05 - Circuit arrangements or systems for wireless supply or distribution of electric power using capacitive coupling
• H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling

Abstract

Foams and methods of fabricating and using the same are provided. The foams can be three-dimensional (3D), free-standing, and/or rigid and can be used as, for example, nanofiller networks. The shape and size of the foam pore interconnected network can be tailorable/tailored. The foams can be, for example, hybrid one-dimensional (1D)/two-dimensional (2D) foams of 1D and 2D materials (e.g., hybrid boron nitride nanotube (BNNT)/boron nitride nanoplatelet (BNNP) foams). A freeze-drying-based method can be used to fabricate bulk porous foam, which can be used for, e.g., nanofiller for polymer nanocomposites.

IPC Classes  ?

• C04B 35/80 - Fibres, filaments, whiskers, platelets, or the like
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 38/06 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by burning-out added substances
• C04B 41/00 - After-treatment of mortars, concrete, artificial stone or ceramicsTreatment of natural stone
• C04B 41/45 - Coating or impregnating
• C04B 41/48 - Macromolecular compounds
• C04B 41/83 - Macromolecular compounds
• C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
• C08K 3/38 - Boron-containing compounds

Abstract

The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Novel dinuclear silver(I) pyrazolido complexes and methods of synthesizing them are provided. Advantageously, the novel silver(I) pyrazolido complexes have excellent antimicrobial activity and methods of using said complexes to treat bacterial, fungal, and viral infections are also provided.

IPC Classes  ?

• A61K 33/38 - SilverCompounds thereof
• A61P 31/04 - Antibacterial agents
• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic Table
• C07F 9/6584 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom

Abstract

2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

IPC Classes  ?

• B01J 31/22 - Organic complexes
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07F 9/00 - Compounds containing elements of Groups 5 or 15 of the Periodic Table

Abstract

The subject invention provides arsinothricin (AST) or salts thereof, and compositions comprising AST or a salt thereof for use as multi-stage antimalarials. The subject invention also provides methods for treating, inhibiting and/or preventing malaria infection and transmission by using AST or salts thereof, or compositions comprising AST or a salt thereof. Advantageously, AST or a salt thereof inhibits glutamine synthetase (GS) of malaria pathogens without exhibiting cytotoxicity to human host.

IPC Classes  ?

• A61K 31/285 - Arsenic compounds
• A61P 33/06 - Antimalarials

Abstract

Antennas with increased bandwidth are provided. The bandwidth of an antenna can be increased by feeding it at a single point through N sides with a 1:N power divider, where N is an integer greater than 1. This bandwidth enhancement approach can be applied to different types of antennas, and with this design approach the bandwidth of an antenna can be increased without increasing its footprint.

IPC Classes  ?

• H01Q 13/02 - Waveguide horns
• H01Q 13/10 - Resonant slot antennas

Abstract

Systems, devices, and methods for measuring blood pressure without the use of a pump are provided. A pumpless blood pressure measuring system or device can be wearable for long periods of time comfortably. The pumpless blood pressure measuring system or device can include a body, at least one tension band connected to the body, at least one pressure sensor configured to be in direct physical contact with the user's body, and a tourniquet mechanism. The tourniquet mechanism can be tightened to lead to artery occlusion such that the at least one pressure plate can determine the blood pressure of the user/wearer.

IPC Classes  ?

• A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Systems and methods are provided for detecting one or more anomalous events in video. Histogram-based noise cleansing, higher-order deep convolutional neural network-based feature extraction, instance segmentation, instance summation, difference calculation, and normalization can be used. Human-in-loop systems and methods can facilitate human decisions for anomaly detection. The decision of an anomaly event can be made by, for example, the instance difference value(s).

IPC Classes  ?

• G06V 20/40 - ScenesScene-specific elements in video content
• G06T 5/00 - Image enhancement or restoration
• G06T 7/10 - SegmentationEdge detection
• G06T 5/40 - Image enhancement or restoration using histogram techniques
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
• G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects

Abstract

2) foams). A freeze-drying-based method can be used to fabricate bulk porous foam, which can be used for, e.g., polymer nanocomposites. A vacuum-assisted infiltration procedure can be used to fabricate a foam-polymer nanocomposite.

IPC Classes  ?

• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds
• C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
• C08K 3/11 - Compounds containing metals of Groups 4 to 10 or of Groups 14 to 16 of the Periodic Table

Abstract

The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.

IPC Classes  ?

• A61K 8/43 - Guanidines
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• C07D 295/215 - Radicals derived from nitrogen analogues of carbonic acid
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• C07C 279/12 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/133 - Amines, e.g. amantadine having hydroxy groups, e.g. sphingosine
• A61P 31/06 - Antibacterial agents for tuberculosis
• C08G 65/00 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
• C08G 71/02 - Polyureas
• A61P 31/04 - Antibacterial agents

Abstract

Antenna arrays with three-dimensional (3D) conformal radiating elements are provided, as well as methods of manufacturing and methods of using the same. An array can include a ground plane and a plurality of unit cells disposed thereon. Each unit cell can include a 3D conformal radiating element. The 3D conformal radiating elements can be, for example, patches (e.g., circular 3D patches), dipoles, or loops, and each radiating element is conformal on a hemispherical shape.

IPC Classes  ?

• H01Q 5/48 - Combinations of two or more dipole type antennas
• H01Q 15/04 - Refracting or diffracting devices, e.g. lens, prism comprising wave-guiding channel or channels bounded by effective conductive surfaces substantially perpendicular to the electric vector of the wave, e.g. parallel-plate waveguide lens

Abstract

Antenna arrays, antenna elements for said arrays, and methods of fabricating and using the same are provided. Antenna arrays can be operated at multiple frequencies, such as at two different frequencies for Radio Detection And Ranging (RADAR) communication and for imaging applications. Each antenna element can include a driven patch that is excited directly and a parasitic patch that is excited by the driven patch.

IPC Classes  ?

• H01Q 19/00 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic
• H01Q 9/04 - Resonant antennas
• H01Q 1/24 - SupportsMounting means by structural association with other equipment or articles with receiving set

Abstract

A system, apparatus, device and/or method for electrical label-free detection of single molecule via a glass or quartz nanopipette biosensor, one type of solid state nanopore biosensor based on resistive pulse measurements, are provided. The method of the subject invention effectively slows down the motion of biomolecules and concentrates them at the nanopipette tip. By driving biomolecules to come out of the nanopipette barrel and move in the fibrin hydrogel, unprecedented sensitivity using the typical size nanopipettes can be achieved. Small molecules such as doxorubicin, ATP, GTP, and short peptides can be easily detected with very high event rate, which greatly reduces the fabrication and measurement difficulties and open opportunities for various new applications for nanopipette biosensors.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 27/447 - Systems using electrophoresis
• G01Q 60/44 - SICM [Scanning Ion-Conductance Microscopy] or apparatus therefor, e.g. SICM probes

Abstract

A trap accessory for attachment to a marine trap that facilitates release of by-catch. A buoyant recovery buoy is operably attached to a trap frame secured to the marine trap. Components for operably attaching the recovery buoy to the trap frame include a latch and attachment components, of which at least one of these components is a Degradable Metal (DM). The DM maintains the integrity of the trap and trap accessory for a pre-determined time, typically 1 year or less. When one or more of the DM components are sufficiently degraded, the recovery buoy is released to open a slot through which animals can escape. A buoy line connected to the trap frame maintains connection between the marine trap and the recovery buoy, which assists in recovery of the marine trap.

IPC Classes  ?

• A01K 69/08 - Rigid traps, e.g. lobster pots

Abstract

Stacked magnetic cores that can achieve high density with a small footprint are provided. A stacked magnetic core can include a plurality of magnetic films with an adhesive film between each magnetic film and the adjacent magnetic film(s). That is, the magnetic films and adhesive films can be disposed in an alternating fashion. Each adhesive film can be a dielectric/insulating film such that each magnetic film is electrically insulated from every other magnetic film.

IPC Classes  ?

• H01F 27/24 - Magnetic cores
• H01F 3/02 - Cores, yokes or armatures made from sheets
• H01F 27/245 - Magnetic cores made from sheets, e.g. grain-oriented
• H01F 27/28 - CoilsWindingsConductive connections

Abstract

Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Systems and methods for generating routes taking into consideration user preferences for scenery, in addition to or alternatively to time, distance, and/or cost are provided. User preferences for scenery during a trip from one location to another can be quantified and used to augment standard routing methods by giving weight to scenic quality. For example, a weighting triangle can be used, where a user chooses a balanced weighting of three factors, including scenic quality, before a route from the starting location to the destination is generated.

IPC Classes  ?

• G01C 21/34 - Route searchingRoute guidance

Abstract

Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

High-entropy ultra-high temperature ceramics (HE-UHTC) coatings deposited on substrates, as well methods for depositing the HE-UHTC coatings on the substrates, are provided. An HE-UHTC electrode can be fabricated via spark plasma sintering (SPS) and then a thin coating of the HE-UHTC can be deposited in a precision-controlled manner on a substrate via an electro-spark deposition process.

IPC Classes  ?

• C04B 35/56 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 35/64 - Burning or sintering processes

Abstract

Systems, architectures, devices, and methods for matching experimentally acquired mass spectrometry data with a peptide database are provided. The system architecture can include a host central processing unit (CPU) system, a bridge connecting the CPU system with a core control register (or registers), a plurality of processing elements (PEs), and a bus arbiter. The PEs can execute the computations in a parallel and asynchronous manner. The bus arbiter can be a first-come first-serve (FCFS)-based bus arbiter (i.e., can utilize an FCFS-based arbitration scheme).

IPC Classes  ?

• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G16B 50/30 - Data warehousingComputing architectures
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The subject invention pertains to a completely new pile splicing system called Grouted Sleeve Coupler Splice (GSCS) for Precast Concrete Piles (PCPs) as an innovative alternative splicing method for connecting driven PCP segments. The provided splicing method is applicable for preplanned situations and provides a durable, labor-friendly, rapid, and economical foundation construction method. In this system, to improve the structural performance, the entire sleeve coupler and a portion of the dowels are partially debonded in short lengths from surrounding concrete. This connection system is novel in conjunction with PCPs and for connecting separate precast pile segments. The provided system offers a completely unique and new method of connecting and splicing PCP segments and other prismatic prefabricated piles.

IPC Classes  ?

• E02D 5/58 - Prestressed concrete piles
• E02D 5/30 - Prefabricated piles made of concrete or reinforced concrete or made of steel and concrete
• E02D 5/52 - Piles composed of separable parts, e.g. telescopic tubes

Abstract

Systems and methods are provided to simulate, approximate, or replicate conditions similar to concrete elements being placed under pressures equivalent to several hundred feet of ocean water and to provide information useful to assess relative durability of concrete without coring or other destructive actions. The quality of concrete can be assessed by measuring the pressure drop of water or other liquid to ingress through the concrete surface under high pressure over time. A rapid assessment of quality of existing concrete is provided. Systems and methods can efficiently assess long term durability of existing concrete elements such as those used in midrise buildings, parking garages, bridge decks, and the like.

IPC Classes  ?

• G01N 33/38 - ConcreteLimeMortarGypsumBricksCeramicsGlass
• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 3/12 - Pressure-testing

Abstract

Dual-band antenna systems and methods of fabricating and using the same are provided. A tunable dual-polarization (left-hand circular polarized (LHCP) and right-hand circular polarized (RHCP)) antenna can be used both for L-band (1.215 gigahertz (GHz)-1.85 GHz) and Ka-band (32.3 GHz-34.2 GHz) operation. The antenna system can be an embedded antenna system, which can be used for 3U CubeSats, with full polarization diversity able to operate in two widely spaced frequency bands (L-band and Ka-band) of the spectrum. The antenna system can include three layers, including a top substrate, a bottom substrate, and a ground plane disposed between the top substrate and the bottom substrate.

IPC Classes  ?

• H01Q 9/04 - Resonant antennas
• H01Q 1/28 - Adaptation for use in or on aircraft, missiles, satellites, or balloons
• B64G 1/10 - Artificial satellitesSystems of such satellitesInterplanetary vehicles
• H01Q 21/00 - Antenna arrays or systems
• B64G 1/66 - Arrangements or adaptations of apparatus or instruments, not otherwise provided for
• H01Q 5/35 - Individual or coupled radiating elements, each element being fed in an unspecified way for different propagation modes using two or more simultaneously fed points

Abstract

Systems and methods for real-time continuous monitoring of fuel cell membrane degradation are provided. At least one microsensor can be used as an inline sensor integrated at the cathode exhaust and/or the anode exhaust of a fuel cell, such as a proton exchange membrane fuel cell (PEMFC)). The microsensor can monitor the PEMFC degradation status by sensing the emission of fluoride.

IPC Classes  ?

• H01M 8/04 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids
• H01M 8/04992 - Processes for controlling fuel cells or fuel cell systems characterised by the implementation of mathematical or computational algorithms, e.g. feedback control loops, fuzzy logic, neural networks or artificial intelligence
• H01M 8/04664 - Failure or abnormal function

Abstract

This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 14/765 - Serum albumin, e.g. HSA
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

High-entropy ultra-high temperature ceramics (HE-UHTC) coatings deposited on substrates, as well methods for depositing the HE-UHTC coatings on the substrates, are provided. An HE-UHTC electrode can be fabricated via spark plasma sintering (SPS) and then a thin coating of the HE-UHTC can be deposited in a precision-controlled manner on a substrate via an electro-spark deposition process.

IPC Classes  ?

• C04B 35/56 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 35/64 - Burning or sintering processes

Abstract

Systems, architectures, devices, and methods for matching experimentally acquired mass spectrometry data with a peptide database are provided. The system architecture can include a host central processing unit (CPU) system, a bridge connecting the CPU system with a core control register (or registers), a plurality of processing elements (PEs), and a bus arbiter. The PEs can execute the computations in a parallel and asynchronous manner. The bus arbiter can be a first-come first-serve (FCFS)-based bus arbiter (i.e., can utilize an FCFS-based arbitration scheme).

IPC Classes  ?

• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G16B 50/30 - Data warehousingComputing architectures
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Systems, devices, machines, and methods for granular material laying are provided. A granular material laying machine can include at least one small storage bin that moves with a distribution head to temporarily store granular material. The at least one small storage bin can be filled when the distribution head brings it in front of an exit hole of a main storage bin (separate from the at least one small storage bin). While the distribution head discharges the granular material at the desired locations, the small temporary storage bin(s) provide(s) the material.

IPC Classes  ?

• E01C 19/20 - Apparatus for distributing, e.g. spreading, granular or pulverulent materials, e.g. sand, gravel, salt, dry binders

Abstract

The subject invention provides compounds as antitoxins for mitigating the toxic effects of algal toxins, e.g., brevetoxins. These compounds are mercaptan based compounds and derivatives that react rapidly with such toxins, e.g., brevetoxins and can be used to treat poisoning in a subject caused by such toxins. The subject invention also provides compositions comprising the mercaptan based compounds and derivatives for use to mitigate the toxic effects of brevetoxins. Further provided are methods of using the mercaptan based compounds and derivatives and compositions for treating and/or preventing brevetoxin poisoning in a subject such a human and marine animal.

IPC Classes  ?

• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)

Abstract

The subject invention provides compositions, systems, and methods for additive manufacturing (AM), including three dimensional printing (3DP) using Digital Light Processing (DLP), of Lunar regolith and Lunar regolith simulants including Greenland Anorthosite Lunar Regolith (GALR) with a photocurable thermosetting polymer. Certain embodiments provide a high solid content of regolith, for example, about 60 wt. % GALR; together with a lower content of additives, for example, about 40 wt. % of a photocurable thermosetting polymer. Embodiments of the provided recipe and processing method can produce parts with low shrinkage, high strength, and favorable thermal properties. Parts have been produced with less than about 6% shrinkage in multiple directions of measurement.

IPC Classes  ?

• B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B33Y 10/00 - Processes of additive manufacturing
• B29K 509/00 - Use of inorganic materials not provided for in groups , as filler
• B29K 101/10 - Thermosetting resins

Abstract

Systems, methods, and frameworks for detecting cryptocurrency wallet artifacts in a file system of a device are provided. The cryptocurrency wallet artifacts can be automatically detected and can include: (i) cryptocurrency wallet application folders; (ii) images containing cryptocurrency artifacts (e.g., mnemonics phrases and/or transactions information); and/or (iii) web browsers artifacts (e.g., cache data, credentials, cookies, and/or bookmarks). This information can be analyzed and extracted using machine learning (ML), natural language processing (NLP), a convolution neural network (CNN), a recurrent neural network (RNN), and/or a string search algorithm.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06N 3/043 - Architecture, e.g. interconnection topology based on fuzzy logic, fuzzy membership or fuzzy inference, e.g. adaptive neuro-fuzzy inference systems [ANFIS]

Abstract

Connection systems and methods for connecting cross-frames to girders in skewed structure. A Tee section can be welded to a girder, and cross-frame members can be welded to the flange of the Tee section. The flange of the Tee section can have main cut-outs to separate the web of the Tee section from the flange of the girder. The flange of the Tee section can optionally have edge cut-outs for providing airflow, such as in humid regions with high potential for corrosion.

IPC Classes  ?

• E01D 2/02 - Bridges characterised by the cross-section of their bearing spanning structure of the I-girder type
• E01D 19/00 - Details of bridges

Abstract

The subject invention provides compounds, peptidomimetics, and methods of synthesis thereof. The subject invention provides the synthesis and use of guanidino acids and/or poly guanidino acids not only as vehicles for drug delivery but as toolbox for drug discovery. The peptidomimetic of the subject invention comprises oligo(guanidino acid)s or poly(guanidino acid)s with guanidines as peptide bond surrogates. The incorporation of the guanidine as amide bond surrogates offers significant differences in polarity, hydrogen bonding capability, and acid-base character.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

Sensors, actuators, energy sources, and data processing for enabling artificial intelligent (AI) integrated automated features of intelligent electronic shoes are provided. The intelligent footwear can gather information from the shoe and send the data to a user interface for monitoring the physical activities of the wearer. A smart thermal actuation system can control the internal temperature of the shoe to offer a comfortable experience to the user. Intelligent footwear can also have systems for multipurpose sensing and actuation modules, which can use energy harvested by the user locomotion or by an energy source accompanied by artificial intelligence to gather and process information for ensuring an enhanced user experience.

IPC Classes  ?

• A43B 3/00 - Footwear characterised by the shape or the use
• A43B 3/38 - Footwear characterised by the shape or the use with electrical or electronic arrangements with power sources
• A43B 7/04 - Footwear with electric batteries, generators, or the like
• A43B 3/46 - Global positioning system [GPS] sensors
• A43B 3/35 - Footwear characterised by the shape or the use with electrical or electronic arrangements with electric heating arrangements
• A43B 3/42 - Footwear characterised by the shape or the use with electrical or electronic arrangements with power sources where power is generated by conversion of mechanical movement to electricity, e.g. by piezoelectric means
• A43B 3/40 - Batteries
• A43B 3/48 - Footwear characterised by the shape or the use with electrical or electronic arrangements with transmitting devices, e.g. GSM or Wi-Fi®

Abstract

Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

IPC Classes  ?

• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• C07D 487/04 - Ortho-condensed systems

Abstract

Drosophila hsp70 fusion promoter that can be used for inducible co-expression of gRNA and Cas9 in HIV-infected cells to target cellular cofactors such as Cyclin T1. A single introduction of such embodiment leads to sustained suppression of HIV replication in stringent, chronically infected HeLa-CD4 cell lines as well as in T-cell lines. In another embodiment, the invention further relates to enhancement of HIV suppression by incorporating cis-acting ribozymes immediately upstream of the gRNA in the inducible CRISPR system construct. The inducible fusion promoter is adaptable for other tissue- or cell-type specific expression of the inducible CRISPR system.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A61P 35/00 - Antineoplastic agents
• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam

Abstract

Gradient refractive index lenses (GRI-Ls) and methods of fabricating the same are provided. GRI-Ls can be fabricated by stereolithography (SLA) and/or photo-assisted, thermal-assisted, and/or other laser-based curing from at least two precursors with a preset refractive index gradation along the planar axis. These lenses are self-focusing lenses and may be convergent or divergent for decreasing and increasing refractive indices from the center, respectively. Rather than a gradation in lens thickness from the center, the GRI-Ls can have a gradation of composition from the center.

IPC Classes  ?

• G02B 3/00 - Simple or compound lenses
• G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics