The present invention relates to the treatment of three-dimensional microcompartments comprising biological elements encapsulated in a crosslinked hydrogel. In particular, the invention relates to a method for treating a three-dimensional microcompartment comprising at least one biological element encapsulated in a crosslinked hydrogel, so as to reinforce the mechanical properties of said microcompartment, characterized in that it comprises a step of rinsing the microcompartment in a rinsing solution comprising at least one cation.
The present invention relates to the treatment of three-dimensional microcompartments comprising biological elements encapsulated in a crosslinked hydrogel. In particular, the invention relates to a method for treating a three-dimensional microcompartment comprising at least one biological element encapsulated in a crosslinked hydrogel, so as to reinforce the mechanical properties of said microcompartment, characterized in that it comprises a step of rinsing the microcompartment in a rinsing solution comprising at least one cation.
The invention relates to the field of three-dimensional cell culture and relates, in particular, to cellular microcompartments, without an extracellular matrix of animal origin, and/or derived from cancer cell lines, for the production of GMP-grade cells and tissues.
The invention relates to a cell encapsulation system (1), the system comprising at least: a first container (11) intended to contain a solution of cells and a second container (12) intended to contain a solution capable of gelling, a millifluidic or microfluidic encapsulation device (20) connected to the containers for forming cellular microcompartments, of which the outer layer is the solution capable of gelling and the core is the solution of cells, wherein each container is connected to an inlet of the encapsulation device by a dispenser (31, 32) associated with a solution movement system (41, 42) capable of causing the solution contained in the container (11, 12) to flow through the dispenser toward the inlet of the encapsulation device (20), characterized in that the first dispenser (31) has at least one upwardly extending portion.
The present invention relates to a neural tissue unit, comprising dopaminergic neurons and neural progenitor cells, wherein said unit is organized in three dimensions (3D) and has a largest dimension of less than 600 μm. The invention also relates to the use thereof as a medicament, in particular in the prevention and/or treatment of neurodegenerative diseases by implanting said unit, alone or encapsulated in a cellular microcompartment, in the nervous system of a mammal, in particular a human.
The invention relates to a system for encapsulating cells, the system comprising at least: two containers (11, 12), one of which is intended to comprise a solution of cells and the other a solution capable of gelling, a millifluidic or microfluidic encapsulation device (13) connected to the containers in order to form cellular microcompartments, wherein the outer layer comprises the solution capable of gelling and the core the cell solution, a collection vessel (15) for collecting the cellular microcompartments and containing a stiffening solution; each container being connected to an inlet of the encapsulation device by one or more distributors (14), and at least one first container (11) of the containers being connected to a solution displacement system (P11, P12) capable of introducing a pressurised gas into the container in order to generate a flow of the solution contained in the container towards the encapsulation device.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes;
nutrition agents for processing living cells other than for
medical purposes; cell culture media other than for medical
purposes; delivery media; micro-tissues obtained from stem
cells for research purposes; cell aggregates for research;
culture matrix for research purposes. Pharmaceutical products; pharmaceutical preparations;
pharmaceutical preparations for tissue regeneration; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cell culture media for
medical or veterinary use; surgical implants obtained from
stem cells; cell growth media for growing cells for medical
use; culture matrices for medical or veterinary use;
micro-tissues. Scientific apparatus for cell culture systems; scientific
apparatus for the analysis and sorting of cell culture;
bioreactors for cell culture; observation apparatus for cell
culture; incubators for cell culture; cell culture apparatus
for laboratory use; software; software used for the
collection, analysis, sorting, communication of biological
information relating to stem cells; measuring apparatus for
controlling the quality of cell production by encapsulation;
cell or molecule encapsulated lines; microscopes;
microfluidic chip parallelizing systems; microfluidic chip
connectors. Apparatus for stem cell regeneration for medical use;
apparatus for cell culture systems for medical purposes;
apparatus for cell culture systems by encapsulation for
medical purposes; apparatus for analyzing and sorting cell
culture for medical purposes. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
scientific research on the differentiation of pluripotent
stem cells into differentiated cells; research and
development in the field of stem cells, cell and gene
therapy and biotechnology; pharmaceutical research and
development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology; software development; research on controlling
the quality of the production of cells by encapsulation;
research on controlling the quality of cell therapy
production.
9.
SPECIFIC LIVER MICROTISSUE COMPRISING AT LEAST THREE DIFFERENT PHENOTYPES OF HEPATOCYTES, AND USES THEREOF
The invention relates to a specific liver microtissue comprising at least 3 different phenotypes of hepatocytes obtained from induced pluripotent stem cells encapsulated in a single three-dimensionally closed microcompartment. The invention also relates to a method for preparing such a liver microtissue and the uses thereof in the treatment or prevention of liver failure.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
10.
SPECIFIC THREE-DIMENSIONAL LIVER MICROTISSUE AND USES IN THE TREATMENT OF LIVER FAILURE
The invention relates to a specific liver microtissue, the largest dimension of which is between 500 and 700 μm, which expresses monooxygenase CYP3A4 with an activity of at least 75,000 RLU per million cells and produces at least 18 μg of urea per million cells in 24 hours. The invention also relates to a method for preparing a liver microtissue of this kind and to the uses thereof in the treatment or prevention of liver failure.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes;
nutrition agents for processing living cells other than for
medical purposes; cell culture media other than for medical
purposes; delivery media; micro-tissues obtained from stem
cells for research purposes; cell aggregates for research;
culture matrix for research purposes. Pharmaceutical products; pharmaceutical preparations;
pharmaceutical preparations for tissue regeneration; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cell culture media for
medical or veterinary use; surgical implants obtained from
stem cells; cell growth media for growing cells for medical
use; culture matrices for medical or veterinary use;
micro-tissues. Scientific apparatus for cell culture systems; scientific
apparatus for the analysis and sorting of cell culture;
bioreactors for cell culture; observation apparatus for cell
culture; incubators for cell culture; cell culture apparatus
for laboratory use; software; software used for the
collection, analysis, sorting, communication of biological
information relating to stem cells; measuring apparatus for
controlling the quality of cell production by encapsulation;
cell or molecule encapsulated lines; microscopes;
microfluidic chip parallelizing systems; microfluidic chip
connectors. Apparatus for stem cell regeneration for medical use;
apparatus for cell culture systems for medical purposes;
apparatus for cell culture systems by encapsulation for
medical purposes; apparatus for analyzing and sorting cell
culture for medical purposes. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
scientific research on the differentiation of pluripotent
stem cells into differentiated cells; research and
development in the field of stem cells, cell and gene
therapy and biotechnology; pharmaceutical research and
development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology; software development; research on controlling
the quality of the production of cells by encapsulation;
research on controlling the quality of cell therapy
production.
The invention relates to a device (1) for aligning two fluidic channels, namely microfluidic or millifluidic channels, of two fluidic elements (2, 3), the alignment device (1) comprising a conical junction between the two fluidic elements (2, 3), wherein a first fluidic element (2) comprises an inner wall (4α) for a first fluidic channel and a male conical portion (5), and a second fluidic element (3) comprises an inner wall (4β) for a second fluidic channel and a female conical portion (8) that is capable of being positioned on the male conical portion (5).
The invention relates to the technical field of treating Parkinson's disease. In particular, the invention relates to a particular biocompatible composition comprising a solution, and heterogeneous cellular elements suspended in said solution, of hyaluronic acid and/or carboxymethyl cellulose (CMC), and at least one biocompatible density agent, and/or at least one modified form of one or more of these molecules.
The invention relates to the technical field of biocompatible compositions, in particular injectable biocompatible compositions. In particular, the invention relates to a particular biocompatible composition comprising a solution and heterogeneous cellular elements suspended in said solution, which elements are selected from isolated cells, cellular microtissues, cell clusters and mixtures thereof, at least two of said cellular elements having a different density and/or size and/or number of cells.
The invention relates to a device (1) for aligning two fluidic channels, namely microfluidic or millifluidic channels, of two fluidic elements (2, 3), the alignment device (1) comprising a conical junction between the two fluidic elements (2, 3), wherein a first fluidic element (2) comprises an inner wall (4α) for a first fluidic channel and a male conical portion (5), and a second fluidic element (3) comprises an inner wall (4β) for a second fluidic channel and a female conical portion (8) that is capable of being positioned on the male conical portion (5).
The invention relates to a system for encapsulating cells, the system comprising at least: two containers (11, 12) intended to contain a solution of cells and a gelling-capable solution, an encapsulating device (13) arranged to form cellular microcompartments, the outer layer of which is the gelling-capable solution and the core of which is the cell solution, a collection tank (15) containing a stiffening solution; a collection circuit (21) for collecting the cellular microcompartments collected by the collection tank; characterised in that the collection tank comprises an outlet (151) for drawing off the stiffening solution from the tank to the collection circuit; and an injection inlet (152) for injecting the stiffening solution into the tank, wherein the injection inlet is arranged such that the direction of injection is substantially tangential to a wall of the tank.
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroidal or spherical shape or substantially ovoid, cylindrical, spheroidal or spherical shape, the smallest dimension of which is between 200 and 400 μm, comprising an external hydrogel layer defining an internal part, said internal part having a granzyme B content of less than 1 μg/ml of medium and comprising between 500 and 5000 lymphocytes forming a three-dimensionally grouped culture. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The invention relates to a system for producing objects, the system comprising: a first stage (1) for generating objects; a second, buffer stage (2) provided with a first separation module (22); a third, harvesting stage (3) comprising a second separation module (31); a valve (26) capable of preventing a fluid from passing from the second stage to the third stage and a control unit (4) arranged so as to control the elements of the system such that the transfer of the objects from the first stage to the separation module of the second stage is continuous, and such that the harvest of the objects separated by the second separation module of the third stage is discontinuous.
The invention relates to the technical field of treating Parkinson's disease. In particular, the invention relates to a particular biocompatible composition comprising a solution, and heterogeneous cellular elements suspended in said solution, of hyaluronic acid and/or carboxymethyl cellulose (CMC), and at least one biocompatible density agent, and/or at least one modified form of one or more of these molecules.
The invention relates to the technical field of biocompatible compositions, in particular injectable biocompatible compositions. In particular, the invention relates to a particular biocompatible composition comprising a solution and heterogeneous cellular elements suspended in said solution, which elements are selected from isolated cells, cellular microtissues, cell clusters and mixtures thereof, at least two of said cellular elements having a different density and/or size and/or number of cells.
The invention relates to the technical field of biocompatible compositions, in particular injectable biocompatible compositions. The invention relates in particular to a biocompatible composition comprising a solution and suspended cellular elements, said cellular elements being selected from isolated cells, cellular microtissues, cell clusters and mixtures thereof, at least two of said cellular elements having a different density and/or size and/or number of cells, said composition being characterized by: - a density of between 800 and 2000 kg/m3; - a resting viscosity, measured using a rheometer at 25°C, of between 0.01 and 1.5 Pa.s; and - a maximum relative velocity of the cellular elements relative to the solution of less than 20 mm.h-1.
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroid or spherical shape or of substantially ovoid, cylindrical, spheroid or spherical shape, the smallest dimension of which is between 200 and 400 μm, comprising an outer hydrogel layer that delimits an internal part, said internal part comprising, in a medium, between 500 and 5000 lymphocytes forming a grouped three-dimensional culture and having a TNF alpha content of less than 100 ng/ml of medium. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical purposes; delivery media for scientific and research use for the delivery of cells cultures other than for medical purposes; micro-tissues obtained from stem cells for research purposes; cell aggregates for research; culture matrix being cell culture media for scientific research purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, viral diseases, namely, HIV (Human Immunodeficiency Virus), HTLV-1 (Human T-lymphotropic Virus Type 1), Hepatitis B, Hepatitis C, Epstein-Barr Virus, Cytomegalovirus, SARS-CoV-2, Varicella-Zoster Virus, Herpes Simplex Virus, Measles Virus, autoimmune diseases, namely, Type 1 Diabetes, Multiple Sclerosis, Hashimoto's Thyroiditis, Rheumatoid Arthritis, Psoriasis, Systemic Lupus Erythematosus, Graves' Disease, Dermatitis, Allergic Eczema, immunodeficiency syndromes, cancers, inflammatory diseases, namely, Psoriasis, Atopic Dermatitis, Eczema, Crohn's Disease, Ulcerative Colitis, Asthma, Ankylosing Spondylitis, Macrophage Activation Syndrome, Hemophagocytic Lymphohistiocytosis; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, viral diseases, namely, HIV (Human Immunodeficiency Virus), HTLV-1 (Human T-lymphotropic Virus Type 1), Hepatitis B, Hepatitis C, Epstein-Barr Virus, Cytomegalovirus, SARS-CoV-2, Varicella-Zoster Virus, Herpes Simplex Virus, Measles Virus, autoimmune diseases, namely, Type 1 Diabetes, Multiple Sclerosis, Hashimoto's Thyroiditis, Rheumatoid Arthritis, Psoriasis, Systemic Lupus Erythematosus, Graves' Disease, Dermatitis, Allergic Eczema, immunodeficiency syndromes, cancers, inflammatory diseases, namely, Psoriasis, Atopic Dermatitis, Eczema, Crohn's Disease, Ulcerative Colitis, Asthma, Ankylosing Spondylitis, Macrophage Activation Syndrome, Hemophagocytic Lymphohistiocytosis; pharmaceutical preparations for tissue regeneration; stem cells for medical or veterinary use; pluripotent stem cells intended for cell and gene therapies; cell culture media for medical or veterinary use; surgical implants comprised of living tissues obtained from stem cells; cell growth media for growing cells for medical use; culture matrices for medical or veterinary use; micro-tissues for use in reducing inflammation, regenerating and replacing cells, tissues and organs Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; scientific apparatus, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus, namely, microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells; measuring apparatus for controlling the quality of cell production by encapsulation; cell or molecule encapsulated lines being cell encapsulation apparatus for laboratory use, for the microencapsulation, culture and large-scale production of stem cells; microscopes; microfluidic systems being System on a chip (SoC) for parallelizing chips; microfluidic chip connectors being connectors for microfluidic devices used in cell culture and analysis Apparatus for stem cell regeneration for medical use; apparatus for cell culture systems for medical purposes, namely, cell culture chambers and capsules; apparatus for cell culture systems by encapsulation for medical purposes; apparatus for analyzing and sorting cell culture for medical purposes, namely, cell culture chambers and capsules Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; scientific research on the differentiation of pluripotent stem cells into differentiated cells; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology; software development in the field of biotechnology and cell therapy; research on controlling the quality of the production of cells by encapsulation; research on controlling the quality of cell therapy production
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical purposes; delivery media for scientific and research use for the delivery of cells cultures other than for medical purposes; micro-tissues obtained from stem cells for research purposes; cell aggregates for research; culture matrix being cell culture media for scientific research purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, viral diseases, namely, HIV (Human Immunodeficiency Virus), HTLV-1 (Human T-lymphotropic Virus Type 1), Hepatitis B, Hepatitis C, Epstein-Barr Virus, Cytomegalovirus, SARS-CoV-2, Varicella-Zoster Virus, Herpes Simplex Virus, Measles Virus, autoimmune diseases, namely, Type 1 Diabetes, Multiple Sclerosis, Hashimoto's Thyroiditis, Rheumatoid Arthritis, Psoriasis, Systemic Lupus Erythematosus, Graves' Disease, Dermatitis, Allergic Eczema, immunodeficiency syndromes, cancers, inflammatory diseases, namely, Psoriasis, Atopic Dermatitis, Eczema, Crohn's Disease, Ulcerative Colitis, Asthma, Ankylosing Spondylitis, Macrophage Activation Syndrome, Hemophagocytic Lymphohistiocytosis; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, viral diseases, namely, HIV (Human Immunodeficiency Virus), HTLV-1 (Human T-lymphotropic Virus Type 1), Hepatitis B, Hepatitis C, Epstein-Barr Virus, Cytomegalovirus, SARS-CoV-2, Varicella-Zoster Virus, Herpes Simplex Virus, Measles Virus, autoimmune diseases, namely, Type 1 Diabetes, Multiple Sclerosis, Hashimoto's Thyroiditis, Rheumatoid Arthritis, Psoriasis, Systemic Lupus Erythematosus, Graves' Disease, Dermatitis, Allergic Eczema, immunodeficiency syndromes, cancers, inflammatory diseases, namely, Psoriasis, Atopic Dermatitis, Eczema, Crohn's Disease, Ulcerative Colitis, Asthma, Ankylosing Spondylitis, Macrophage Activation Syndrome, Hemophagocytic Lymphohistiocytosis; pharmaceutical preparations for tissue regeneration; stem cells for medical or veterinary use; pluripotent stem cells intended for cell and gene therapies; cell culture media for medical or veterinary use; surgical implants comprised of living tissues obtained from stem cells; cell growth media for growing cells for medical use; culture matrices for medical or veterinary use; micro-tissues for use in reducing inflammation, regenerating and replacing cells, tissues and organs Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; scientific apparatus, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus, namely, microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells; measuring apparatus for controlling the quality of cell production by encapsulation; cell or molecule encapsulated lines being cell encapsulation apparatus for laboratory use, for the microencapsulation, culture and large-scale production of stem cells; microscopes; microfluidic systems being System on a chip (SoC) for parallelizing chips; microfluidic chip connectors being connectors for microfluidic devices used in cell culture and analysis Apparatus for stem cell regeneration for medical use; apparatus for cell culture systems for medical purposes, namely, cell culture chambers and capsules; apparatus for cell culture systems by encapsulation for medical purposes; apparatus for analyzing and sorting cell culture for medical purposes, namely, cell culture chambers and capsules Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; scientific research on the differentiation of pluripotent stem cells into differentiated cells; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology; software development in the field of biotechnology and cell therapy; research on controlling the quality of the production of cells by encapsulation; research on controlling the quality of cell therapy production
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use; Cell and microtissue culture media for scientific and laboratory use; Micro-tissues obtained from stem cells Research purposes; Cell aggregates for research purposes; Culture matrix for research purposes. Pharmaceuticals; Pharmaceutical preparations; Tissue-regenerative pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells; Cell growth media for growing cells for medical use; Culture matrices for medical or veterinary use; Micro-tissues. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for use in laboratories; Software; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells; Measuring devices for quality control in cell production through encapsulation; Microscopes; Parallelisation systems for microfluid chips; Connectors for microfluid chips. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Scientific research on the differentiation of pluripotent stem cells into differentiated cells; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Scientific laboratory services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology; Software development; Research on quality control in cell production through encapsulation; Research on quality control in cellular therapy production.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use; Cell and microtissue culture media for scientific and laboratory use; Micro-tissues obtained from stem cells Research purposes; Cell aggregates for research purposes; Culture matrix for research purposes. Pharmaceuticals; Pharmaceutical preparations; Tissue-regenerative pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells; Cell growth media for growing cells for medical use; Culture matrices for medical or veterinary use; Micro-tissues. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for use in laboratories; Software; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells; Measuring devices for quality control in cell production through encapsulation; Microscopes; Parallelisation systems for microfluid chips; Connectors for microfluid chips. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Scientific research on the differentiation of pluripotent stem cells into differentiated cells; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Scientific laboratory services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology; Software development; Research on quality control in cell production through encapsulation; Research on quality control in cellular therapy production.
The present invention relates to the field of cellular biology and more particularly that of cell culture. The invention thus relates to a method for differentiating pluripotent cells into neural cells that is suitable and optimized for three-dimensional cell culture. The neural cells thus obtained can in particular be used in cell therapy for treating a neurodegenerative disease, for example Parkinson's disease.
The invention relates to a system (1) for encapsulating cells, comprising at least two containers (21, 22), one of the containers comprising a solution of cells (S1) and the other of the containers comprising a solution capable of gelling (S2); an encapsulation device (3) connected to the containers via distributors (21a, 22a) and arranged to form cellular microcompartments (MC), the outer layer of which is the solution capable of gelling and the core of which is the solution of cells; a stiffening bath (4) arranged to collect the cellular microcompartments and to cause stiffening of the outer layer of each collected cellular microcompartment; characterized in that it comprises at least one member (22b) capable of electrically charging at least one of the solutions with a first electrical potential (V1), and in that the stiffening bath is electrically charged with a second electrical potential (V2).
The invention relates to the technical field of three-dimensional cellular microcompartment culture. In particular, the invention relates to a method for preparing a three-dimensional cellular microcompartment comprising the implementation of an encapsulation of at least one cell in hydrogel so as to form a suspension comprising cellular microcompartments in a soaking solution and of at least one step applying a gravity of at least 10 g to at least one cell and/or at least one cellular microcompartment. The invention also relates to a device suitable for implementing at least one part of said method.
The invention relates to a device (1) for filtering mesoscopic cellular objects in suspension (OCMS), comprising a body (2) having at least a first port (5) and a second port (6) and a filtering membrane (3) extending along a plane P in the body (2), thus defining two compartments, and able to prevent the passage of the OCMS from one compartment to the other, the first port (5) being intended for the injection and withdrawal of the OCMS immersed in a soaking solution and/or a rinsing solution, and the second port (6) being intended for the withdrawal and injection of the soaking solution and/or the rinsing solution. According to the invention, the injection into the first port (5) takes place in a direction D that is not substantially orthogonal to the plane P of the filtering membrane (3).
The present invention relates to the fields of cell transduction and transfection in a three-dimensional cell culture model. More particularly, the invention relates to a particular three-dimensional cellular microcompartment comprising in particular at least one cell, at least one transduction agent and/or at least one transfection agent.
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
34.
PUCE FLUIDIQUE ET SYSTEME D'ENCAPSULATION DE CELLULES
The invention relates to a fluidic chip (1) composed of a body (2), a primary inlet (5) and at least one secondary inlet (6) that is not coaxial with the primary inlet (5), each primary inlet (5) and secondary inlet (6) being intended to receive a substance and an outlet (7), wherein the primary inlet (5) is connected to the outlet (7) by a primary channel (8) comprising a substantially straight portion defining a central axis Z for the fluidic chip (1) and the secondary inlet is also connected to the outlet (7) by a secondary channel (9). According to the invention, the secondary channel (9) is divided into at least two secondary ducts (11) of the same size that meet in a circular injection duct that is coaxial with the primary duct (8) in such a way as to be equidistributed around the central axis Z.
A fluidic chip composed of a body including a main inlet and at least one secondary inlet not coaxial to the main inlet, each main and secondary inlet being configured to receive a substance and an outlet, the main inlet is connected to the outlet by a main channel including a substantially rectilinear portion defining a central axis Z for the fluidic chip, the secondary inlet is also connected to the outlet by a secondary channel. The secondary channel is divided into at least two secondary ducts of the same dimension that join in a circular duct for injection coaxial with the main channel in an evenly distributed manner around the central axis Z.
The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and inside said external layer at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total population of cells present in the microcompartment or in the microcompartment assembly are cells having at least one mutation.
The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and inside said external layer at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total population of cells present in the microcompartment or in the microcompartment assembly are cells having at least one mutation.
The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The present invention relates to the field of three-dimensional cell culture and relates, in particular, to cellular microcompartments, without an extracellular matrix of animal origin, and/or derived from cancer cell lines, for the production of GMP-grade cells and tissues.
A connection device between two micro-channels or two milli-channels of two fluidic elements including a complementary arrangement for holding the device with at least one of the two fluidic elements. A micro-fluidic or milli-fluidic chip including a connection device between a micro-channel or a milli-channel of the chip and a micro-channel or a milli-channel of a fluidic element.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes;
nutrition agents for processing living cells other than for
medical purposes; cell culture media other than for medical
purposes. Pharmaceutical products; pharmaceutical preparations; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cultures of cell media
for medical and veterinary use; surgical implants obtained
from stem cells. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
research and development in the field of stem cells, cell
and gene therapy and biotechnology; pharmaceutical research
and development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes;
nutrition agents for processing living cells other than for
medical purposes; cell culture media other than for medical
purposes. Pharmaceutical products; pharmaceutical preparations; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cultures of cell media
for medical and veterinary use; surgical implants obtained
from stem cells. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
research and development in the field of stem cells, cell
and gene therapy and biotechnology; pharmaceutical research
and development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology.
43.
LARGE CELLULAR MICROCOMPARTMENTS COMPRISING A PLURALITY OF CYSTS
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroid or spherical shape, or substantially ovoid, cylindrical, spheroid or spherical shape, comprising an external hydrogel layer defining an internal part (14), said internal part comprising at least:
extracellular matrix elements, and
at least two cysts, each cyst being formed by at least one layer of human or animal cells organised three-dimensionally around a lumen,
the smallest radius or the average radius of the internal part being at least 100 μm. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The invention relates to a cellular microcompartment that can be used clinically, termed "GMP", comprising at least: a. a cell layer, b. an external hydrogel layer, and c. a fibrin mesh placed between the external hydrogel layer and said cell layer. The invention also relates to a method for preparing the microcompartment, and also to the use of a kit comprising a fibrinogen solution and a thrombin solution, for preparing a cellular microcompartment.
A cellular microcompartment comprising: at least one layer of cells, an outer layer of hydrogel, and a fibrin mesh arranged between the outer layer of hydrogel and said layer of cells, the cellular microcompartment being compliant with regulations for Good Manufacturing Practices (GMP) and suitable for clinical applications, as well as methods for preparing the cellular microcompartment, and methods in which the cellular microcompartment is used for production of cells and/or tissues, including a large-scale production.
The invention relates to a connection device between two microchannels or two millichannels of two fluid elements, comprising complementary means for holding the device in relation to at least one of the two fluid elements. The invention also relates to a microfluid or millifluid chip comprising a connection device between a microchannel or a millichannel of the chip and a microchannel or a millichannel of a fluid element. Finally, the invention relates to a connection device between two microchannels or two millichannels of two fluid elements, comprising complementary means for holding the device in relation to the two fluid elements.
The invention relates to a compacted tissue of human cardiac cells expressing cardiac troponin C, which is contractile and has a low spontaneous contraction frequency. The invention also relates to the use of the tissue, in particular in the treatment of a cardiac pathology, particularly ischaemic heart disease.
C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
49.
SPECIFIC LIVER MICROTISSUE COMPRISING AT LEAST THREE DIFFERENT PHENOTYPES OF HEPATOCYTES, AND USES THEREOF
"The invention relates to a specific liver microtissue comprising at least three different phenotypes of hepatocytes obtained from induced pluripotent stem cells encapsulated in a single three-dimensionally closed microcompartment. The invention also relates to a method for preparing a liver microtissue of this kind and to the uses thereof in the treatment or prevention of liver failure."
"The invention relates to a specific liver microtissue, the largest dimension of which is between 500 and 700 µm, said microtissue expressing monooxygenase CYP3A4 with an activity of at least 75,000 RLU per million cells and producing at least 18 µg of urea per million cells in 24 hours. The invention also relates to a method for preparing a liver microtissue of this kind and to the uses thereof in the treatment or prevention of liver failure."
The invention relates to a specific liver microtissue comprising at least 3 different phenotypes of hepatocytes obtained from induced pluripotent stem cells encapsulated in a single three-dimensionally closed microcompartment. The invention also relates to a method for preparing such a liver microtissue and to the uses thereof in the treatment or prevention of liver failure.
The invention relates to cellular microcompartments, each microcompartment successively comprising the following layers, which are organised around at least one lumen: —at least one inner layer of human cells undergoing cardiac differentiation, expressing at least one gene chosen from PDGFRα, MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1 and TBX5, —at least one intermediate layer of isotonic aqueous solution, and—at least one outer hydrogel layer. The invention also relates to the cardiac tissues obtained from said microcompartments and the use thereof, particularly in the treatment of heart disease.
The invention relates to a liver microtissue, preferably a liver microtissue comprising at least 3 different phenotypes of liver cells obtained from induced pluripotent stem cells encapsulated in a single three-dimensional closed microcompartment. The invention also relates to a method for preparing the liver microtissue and its uses in treatment or prevention of liver failure.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
54.
LIVER MICROTISSUE AND USES IN TREATMENT OF LIVER FAILURE
The invention relates to a liver microtissue, preferably, the liver microtissue having the largest dimension between 500 and 700 μm, and the liver microtissue expressing CYP3A4 monooxygenase with an activity of at least 75,000 RLU per million cells and producing at least 18 ag of urea per million cells per 24 hours. The invention also relates to a method for producing the liver microtissue from pluripotent stem cells, and uses of the liver microtissue in treatment and/or prevention of liver failure.
The invention relates to a specific liver microtissue, the largest dimension of which is between 500 and 700 µm, which expresses monooxygenase CYP3A4 with an activity of at least 75,000 RLU per million cells and produces at least 18 µg of urea per million cells in 24 hours. The invention also relates to a method for preparing a liver microtissue of this kind and to the uses thereof in the treatment or prevention of liver failure.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical and veterinary purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns, spinal cord injuries, Huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, functional microtissues that facilitate transplantation and graft integration; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns, spinal cord injuries, Huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, functional microtissues that facilitate transplantation and graft integration; stem cells for medical or veterinary use; pluripotent stem cells for medical use intended for cell and gene therapies; cultures of cell media for medical and veterinary use; surgical implants comprised of living tissues obtained from stem cells Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical and veterinary purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns, spinal cord injuries, Huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, functional microtissues that facilitate transplantation and graft integration; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns, spinal cord injuries, Huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, functional microtissues that facilitate transplantation and graft integration; stem cells for medical or veterinary use; pluripotent stem cells for medical use intended for cell and gene therapies; cultures of cell media for medical and veterinary use; surgical implants comprised of living tissues obtained from stem cells Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
58.
CELLULAR MICROCOMPARTMENTS COMPRISING LYMPHOCYTES FORMING A GROUPED 3D CULTURE AND HAVING A LOW TNF ALPHA CONTENT
"The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroidal or spherical shape or substantially ovoid, cylindrical, spheroidal or spherical shape, the smallest dimension of which is between 200 and 400 µm, comprising an external hydrogel layer defining an internal part, said internal part having a granzyme B content of less than 1 µg/mL of medium and comprising between 500 and 5000 lymphocytes forming a three-dimensionally grouped culture. The invention also relates to a method for producing such a microcompartment or microcompartment assembly."
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroidal or spherical shape or substantially ovoid, cylindrical, spheroidal or spherical shape, the smallest dimension of which is between 200 and 400 µm, comprising an external hydrogel layer defining an internal part, said internal part having a granzyme B content of less than 1 µg/ml of medium and comprising between 500 and 5000 lymphocytes forming a three-dimensionally grouped culture. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroid or spherical shape or of substantially ovoid, cylindrical, spheroid or spherical shape, the smallest dimension of which is between 200 and 400 µm, comprising an outer hydrogel layer that delimits an internal part, said internal part comprising, in a medium, between 500 and 5000 lymphocytes forming a grouped three-dimensional culture and having a TNF alpha content of less than 100 ng/ml of medium. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
"The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional cellular microcompartments of ovoid, cylindrical, spheroidal or spherical shape or substantially ovoid, cylindrical, spheroidal or spherical shape, the smallest dimension of which is between 200 and 400 µm, comprising an external hydrogel layer defining an internal part, said internal part comprising between 500 and 5000 lymphocytes forming a three-dimensionally grouped culture and having a TNF alpha content of less than 100 ng/mL of medium. The invention also relates to a method for producing such a microcompartment or microcompartment assembly."
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Pharmaceuticals; Pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Laboratory (Scientific -) services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Pharmaceuticals; Pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Laboratory (Scientific -) services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology.
64.
METHOD FOR CHARACTERIZING A BIOLOGICAL MICROTISSUE USING IMAGING
The invention relates to a method for in vitro characterization of a eukaryote biological microtissue by imaging by means of a phase measurement technique without a reference beam, and the use of this method in vitro characterization in particular for:
monitoring the quality of a microtissue,
measuring the increase of the biomass of a microtissue during its growth and/or its amplification
following the differentiation and/or the organization of a microtissue during its maturation,
determining the phenotype of cells of the microtissue, and/or
confirming the absence of non-differentiated cells in the microtissue.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
65.
LARGE CELLULAR MICROCOMPARTMENTS COMPRISING A PLURALITY OF CYSTS
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional microcompartments of ovoid, cylindrical, spheroid or spherical shape, or substantially ovoid, cylindrical, spheroid or spherical shape, comprising an external hydrogel layer defining an internal part (14), said internal part comprising at least: - extracellular matrix elements, and - at least two cysts, each cyst being formed by at least one layer of human or animal cells organised three-dimensionally around a lumen, the smallest radius or the average radius of the internal part being at least 100 µm. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The invention relates to a three-dimensional cellular microcompartment or an assembly of three-dimensional microcompartments of ovoid, cylindrical, spheroid or spherical shape, or substantially ovoid, cylindrical, spheroid or spherical shape, comprising an external hydrogel layer defining an internal part (14), said internal part comprising at least: - extracellular matrix elements, and - at least two cysts, each cyst being formed by at least one layer of human or animal cells organised three-dimensionally around a lumen, the smallest radius or the average radius of the internal part being at least 100 µm. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.
The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and, inside said external layer, at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total cell population present in the microcompartment or in the microcompartment assembly are cells having at least one mutation. The invention also relates to a method for preparing such a microcompartment or microcompartment assembly.
The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and, inside said external layer, at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total cell population present in the microcompartment or in the microcompartment assembly are cells having at least one mutation. The invention also relates to a method for preparing such a microcompartment or microcompartment assembly.
The invention relates to three-dimensional tissue units which are hollow and which comprise, when organized about an internal opening, at least one layer of living human retinal pigment epithelium cells which are differentiated, the basal face of each cell pointing outwards and the apical face pointing towards the internal opening. The invention also relates to these tissue units for use in the treatment of retinopathies, and to a method for preparing these tissue units and an implantation kit.
The invention relates to cellular microcompartments, each microcompartment successively comprising the following layers, which are organised around at least one lumen: - at least one inner layer of human cells undergoing cardiac differentiation, expressing at least one gene chosen from PDGFRα, MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1 and TBX5, - at least one intermediate layer of isotonic aqueous solution, and - at least one outer hydrogel layer. The invention also relates to the cardiac tissues obtained from said microcompartments and the use thereof, particularly in the treatment of heart disease.
The invention relates to a compacted tissue of human cardiac cells expressing cardiac troponin C, which is contractile and has a low spontaneous contraction frequency. The invention also relates to the use of the tissue, in particular in the treatment of a cardiac pathology, particularly ischaemic heart disease.
36 - Financial, insurance and real estate services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing educational scholarships; Providing grants for scientific research; Financial patronage and sponsoring for scientific research; Financing of scientific research projects. Organizing of science competitions; Issuing of educational awards; Issuing of scientific awards; Arranging of award ceremonies; Publishing of scientific papers; Publication of the results of clinical trials; Publication of scientific information journals; Publishing and issuing scientific papers in relation to biotechnology; Providing online electronic publications, not downloadable; Organising exhibitions For research purposes; Providing of training and teaching in the field of science and research. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Scientific laboratory services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology; Scientific research in relation to the following fileds: production of differentiated cells by encapsulation; Scientific research in relation to the following fileds: Laboratory apparatus, Medical apparatus, educational apparatus and simulators; Scientific research in relation to the following fileds: Cell analysis, cell sorting and cell filtration.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biological preparations for use in industry and science; Biological preparation for use in cell cultures other than for medical or veterinary use; Cultures of cell media for scientific and research use, other than for medical or veterinary use; Biological tissue cultures, other than for medical or veterinary purposes; Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells, other than for medical use; Media for cell culture for use in the biotechnical industry, other than for medical use; Media for cell culture for use in non-medical research laboratories Scientific apparatus for cell culture systems, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; Cultured cell scientific apparatus for scientific use for analysis and sorting of cells, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; Bioreactor for cell culturing; Cultured cell observing apparatus for laboratory use, namely cell culture dishes and tissue culture flaks ; Cell culture incubators; Cell culture apparatus for laboratory use, namely, namely cell culture dishes and tissue culture flaks; cell filtration apparatus for laboratory use; cell sorting apparatus for laboratory use; micro fluidics chips being microfluidic chips for droplet and particle generation for laboratory use; downloadable software used for the collection, analysis, sorting, and communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; Apparatus for culture cell systems for medical use, namely, cell culture chambers and capsules for use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; Apparatus for encapsulation of culture cell systems for use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; Cell culture apparatus for analysis and sorting of cells for use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; cell filtration apparatus for use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; cell sorting apparatus for {use in the diagnosis and treatment of Parkinson's disease, neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis, acute liver failure, Age-related macular degeneration, limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases Publishing and issuing of scientific papers in the in the field of biotechnology and medical technology; Publication of the results of clinical trials; Publication of scientific information journals; Publishing and issuing scientific papers in relation to biotechnology Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology; scientific research on the production of differentiated cells by encapsulation; scientific research in the field of laboratory apparatus, medical apparatus, educational apparatus and simulators; scientific research in the field of cell analysis, cell sorting and cell filtration
74.
METHOD FOR CHARACTERISING A BIOLOGICAL MICRO TISSUE USING IMAGING
The invention relates to a method for in vitro imaging characterisation of a eucaryotic biological micro tissue using a technique for measuring the phase without a reference beam, and the use of said method in particular for: - assessing the quality of micro tissue, - measuring the increase in the biomass of a micro tissue during its growth and/or its amplification, - monitoring the differentiation and/or the organisation of a micro tissue during its maturation, - determining the phenotype of micro tissue cells, and/or - confirming the absence of non-differentiated cells in the micro tissue.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biological preparations for use in industry and science;
biological preparation for use in cell cultures other than
for medical or veterinary use; cultures of cell media [other
than for medical or veterinary use]; biological tissue
cultures, other than for medical or veterinary purposes;
stem cells for research purposes; stem cells for scientific
purposes; nutritive agents for processing living cells
[other than for medical use]; media for cell culture other
than medical use. Apparatus for scientific research and laboratory apparatus;
scientific apparatus for cell culture systems; cultured cell
scientific apparatus for analysis and sorting; bioreactor
for cell culturing; cultured cell observing apparatus; cell
culture incubators; cell culture apparatus for laboratory
use; software used for the collection, analysis, sorting,
communication of biological information relating to stem
cells. Medical apparatus; apparatus for the regeneration of stem
cells for medical purposes; apparatus for culture cell
systems for medical use; apparatus for encapsulation of
culture cell systems for medical use; cell culture apparatus
for analysis and sorting for medical use. Publishing of scientific papers; publication of the results
of clinical trials; publication of scientific information
journals; publishing and issuing scientific papers in
relation to biotechnology. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
research and development in the field of stem cells, cell
and gene therapy and biotechnology; pharmaceutical research
and development; scientific laboratory services; providing
information with respect to scientific research in the field
of stem cells, cell and gene therapy and biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific
purposes; nutrition agents for processing living cells
other than for medical purposes; cell culture media other
than for medical purposes. Pharmaceutical products; pharmaceutical preparations; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cell culture media
for medical or veterinary use; surgical implants obtained
from stem cells. Scientific apparatus for cell culture systems; scientific
apparatus for the analysis and sorting of cell culture;
bioreactors for cell culture; observation apparatus for cell
culture; incubators for cell culture; cell culture
apparatus for laboratory use; software used for the
collection, analysis, sorting, communication of biological
information relating to stem cells. Apparatus for the regeneration of stem cells for medical
use; apparatus for cell culture systems for medical
purposes; apparatus for cell culture systems by
encapsulation for medical purposes; apparatus for analyzing
and sorting cell culture for medical purposes. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
research and development in the field of stem cells, cell
and gene therapy and biotechnology; pharmaceutical research
and development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns; stem cells for medical or veterinary use; pluripotent stem cells for medical purposes intended for cell and gene therapies; cell culture media for cultivating human cells for medical or veterinary use; surgical implants comprised of living tissues obtained from stem cells Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; scientific apparatus, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus, namely, microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for medical use; apparatus for cell culture systems for medical purposes, namely, cell culture chambers and capsules; apparatus for cell culture systems by encapsulation for medical purposes, namely, cell culture chambers and capsules; apparatus for analyzing and sorting cell culture for medical purposes, namely, cell culture chambers and capsules Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Biological preparation, namely cell freezing reagents, cell dissociation reagents, gelling agents, cell growth factors, supplements for supporting the growth and development of cells and tissues in culture for use in cell cultures for scientific research; cell culture media for scientific or research purposes; biological tissue cultures for use in scientific research purposes; stem cells for research purposes; stem cells for scientific purposes; cell culture media for scientific or research purposes.
(2) Scientific apparatus for cell culture systems namely cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; laboratory machine for analyzing and sorting cell culture media; bioreactor for cell culturing; cultured cell observing apparatus, namely a microscope; cell culture incubators; cell culture apparatus for laboratory use, namely cell culture dishes and tissue culture flasks; software in the field of scientific research used for the collection, analysis, sorting, communication of biological information relating to stem cells.
(3) Laboratory equipment, namely machine for the regeneration of stem cells for medical purposes; Laboratory equipment, namely storage device for cell cultures for medical purposes; Laboratory equipment, namely machine for encapsulation for medical use; Laboratory equipment, namely machine for analyzing and sorting cell culture for medical use (1) Publishing of scientific papers; publication of the results of clinical trials; publication of scientific information journals; publishing and issuing scientific papers in relation to biotechnology.
(2) Laboratory research in the field of pharmaceutical biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; scientific research in the field of stem cells, cell and gene therapy and pharmaceutical biotechnology; pharmaceutical research and development; scientific laboratory research services; providing information, namely laboratory results with respect to scientific research in the field of stem cells, cell and gene therapy and pharmaceutical biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biological preparations for use in industry and science; biological preparation for use in cell cultures other than for medical or veterinary use; cell culture media for scientific and research use, not for medical or veterinary use; biological tissue cultures, other than for medical or veterinary purposes; stem cells for research purposes; stem cells for scientific purposes; nutritive agents for processing living cells other than for medical use; media for cell culture for laboratory use, other than medical use Scientific apparatus for cell culture systems, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; cultured cell apparatus for scientific use for analysis and sorting of cells, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactor for cell culturing; cultured cell observing apparatus; cell culture incubators; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; software used for the collection, analysis, sorting, communication of biological information relating to stem cells; scientific apparatus for the analysis and sorting of cell culture, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus for cell culture, namely, microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flasks; downloadable computer software used for the collection, analysis, sorting and communication of biological information relating to stem cells apparatus for the regeneration of stem cells for medical purposes; apparatus for culture cell systems for medical use, namely cell culture chambers and capsules; apparatus for encapsulation of culture cell systems for medical use; cell culture apparatus for analysis and sorting of cells for medical use Publishing and issuing of scientific papers in the field of biotechnology and medical technology; publication of the results of clinical trials; publication of scientific information journals; publishing and issuing scientific papers in relation to biotechnology Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biological preparations for use in industry and science; Biological preparation for use in cell cultures other than for medical or veterinary use; Cultures of cell media [other than for medical or veterinary use]; Biological tissue cultures, other than for medical or veterinary purposes; Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture for use in the biotechnical industry; Media for cell culture for use in non-medical research laboratories. Scientific research and laboratory apparatus, educational apparatus and simulators; Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; cell filtration apparatus for laboratory use; cell sorting apparatus for laboratory use; microfluidics chips for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Medical devices; Medical apparatus and instruments; Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use; cell filtration apparatus for medical use; cell sorting apparatus for medical use. Publishing of scientific papers; Publication of the results of clinical trials; Publication of scientific information journals; Publishing and issuing scientific papers in relation to biotechnology. Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology; scientific research on the production of differentiated cells by encapsulation; scientific research in the field of laboratory apparatus, medical apparatus, educational apparatus and simulators; scientific research in the field of cell analysis, cell sorting and cell filtration.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Stem cells for research; stem cells for scientific purposes; cell culture media for scientific or research purposes
(2) Pharmaceutical preparations namely, treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, Huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases, functional microtissues that facilitate transplantation and graft integration; stem cells for medical purposes, stem cells for veterinary purposes; pluripotent stem cells intended for cell and gene therapies; cell culture media for stem cells and for differentiation for cell therapies; surgical implants obtained from stem cells
(3) Cell culture microplates, bioreactors for cell culture; observation tanks for cell culture; incubators for cell culture; cell culture apparatus for laboratory use namely centrifuges; software used for the collection, analysis, sorting, communication of biological scientific research information relating to stem cells
(4) Laboratory equipment, namely machine for the regeneration of stem cells for medical use; Laboratory equipment, namely storage device for cell cultures for medical purposes; Laboratory equipment, namely machine for cell cultures by encapsulation for medical purposes; Laboratory equipment, namely machine for analyzing and sorting cell culture for medical purposes (1) Scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents for processing living cells other than for medical purposes; cell culture media for laboratory use, other than for medical purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart disease, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury, skin burns, spinal cord injuries, huntington disease, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, burns, cancer, osteoarthritis, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases; stem cells for medical or veterinary use; pluripotent stem cells intended for cell and gene therapies for medical use; cell culture media for medical or veterinary use, namely, culture media for cultivating human cells and microorganism cells; surgical implants comprising living tissue obtained from stem cells Scientific apparatus for cell culture systems, namely cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; scientific apparatus for the analysis and sorting of cell culture, namely laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus for cell culture, namely microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely cell culture dishes and tissue culture flaks; downloadable computer software used for the collection, analysis, sorting and communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for medical use; apparatus for cell culture systems for medical purposes, namely cell culture chambers and capsules; apparatus for encapsulation of cell culture systems for medical purposes; apparatus for analyzing and sorting cell culture for medical purposes Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
83.
HOLLOW THREE-DIMENSIONAL UNIT MADE FROM RETINAL TISSUE AND USE THEREOF IN THE TREATMENT OF RETINOPATHIES
The invention relates to three-dimensional tissue units which are hollow and which comprise, when organised about an internal opening, at least one layer of living human retinal pigment epithelium cells which are differentiated, the basal face of each cell pointing outwards and the apical face pointing towards the internal opening. The invention also relates to these tissue units for use in the treatment of retinopathies, and to a method for preparing these tissue units and an implantation kit.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Pharmaceuticals; Pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Scientific laboratory services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biological preparations for use in industry and science; Biological preparation for use in cell cultures other than for medical or veterinary use; Cultures of cell media [other than for medical or veterinary use]; Biological tissue cultures, other than for medical or veterinary purposes; Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Apparatus for scientific research and laboratory apparatus; Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Medical apparatus; Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use. Publishing of scientific papers; Publication of the results of clinical trials; Publication of scientific information journals; Publishing and issuing scientific papers in relation to biotechnology. Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing information with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Pharmaceuticals; Pharmaceutical preparations; Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use. Laboratory researches in the field of biotechnology; Scientific researches on stem cells; Scientific researches on the production of pluripotent stem cells by encapsulation; Research and development in the field of stem cells, cell and gene therapy and biotechnology; Pharmaceutical research and development; Scientific laboratory services; Providing information about scientific research in the field of stem cells, cell and gene therapy and biotechnology.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Stem cells for medical or veterinary purposes; Pluripotent stem cells for medical or veterinary use for cell and gene therapies; Cell culture media for cultivating human and animal cells for medical or veterinary use; Surgical implants comprised of living tissues obtained from stem cells Apparatus for the regeneration of stem cells for laboratory or scientific purposes; Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; Cultured cell scientific apparatus, namely, laboratory pipettes and capsules for analysis and sorting of cell cultures; Bioreactor for cell culturing; Cultured cell observing apparatus, namely, microscopes for cell culture; Cell culture incubators for laboratory use; Cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; Downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for medical purposes
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Stem cells for medical or veterinary purposes; Pluripotent stem cells for medical or veterinary use for cell and gene therapies; Cell culture media for cultivating human and animal cells for medical or veterinary use; Surgical implants comprised of living tissues obtained from stem cells Apparatus for the regeneration of stem cells for laboratory or scientific purposes; Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; Cultured cell scientific apparatus, namely, laboratory pipettes and capsules for analysis and sorting of cell cultures; Bioreactor for cell culturing; Cultured cell observing apparatus, namely, microscopes for cell culture; Cell culture incubators for laboratory use; Cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; Downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for medical purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific
purposes; nutrition agents for processing living cells
other than for medical purposes; cell culture media other
than for medical purposes. Pharmaceutical products; pharmaceutical preparations; stem
cells for medical or veterinary use; pluripotent stem cells
intended for cell and gene therapies; cell culture media
for medical or veterinary use; surgical implants obtained
from stem cells. Scientific apparatus for cell culture systems; scientific
apparatus for the analysis and sorting of cell culture;
bioreactors for cell culture; observation apparatus for cell
culture; incubators for cell culture; cell culture
apparatus for laboratory use; software used for the
collection, analysis, sorting, communication of biological
information relating to stem cells. Apparatus for the regeneration of stem cells for medical
use; apparatus for cell culture systems for medical
purposes; apparatus for cell culture systems by
encapsulation for medical purposes; apparatus for analyzing
and sorting cell culture for medical purposes. Laboratory research in the field of biotechnology;
scientific research on stem cells; scientific research on
the production of pluripotent stem cells by encapsulation;
research and development in the field of stem cells, cell
and gene therapy and biotechnology; pharmaceutical research
and development; scientific laboratory services; providing
informations with respect to scientific research in the
field of stem cells, cell and gene therapy and
biotechnology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Stem cells for research purposes; Stem cells for scientific purposes; Nutritive agents for processing living cells [other than for medical use]; Media for cell culture other than medical use. Stem cells for medical or veterinary purposes; Pluripotent stem cells for cell and gene therapies; Media for cell culture for medical or veterinary use; Surgical implants obtained from stem cells. Scientific apparatus for cell culture systems; Cultured cell scientific apparatus for analysis and sorting; Bioreactor for cell culturing; Cultured cell observing apparatus; Cell culture incubators; Cell culture apparatus for laboratory use; Software used for the collection, analysis, sorting, communication of biological information relating to stem cells. Apparatus for the regeneration of stem cells for medical purposes; Apparatus for culture cell systems for medical use; Apparatus for encapsulation of culture cell systems for medical use; Cell culture apparatus for analysis and sorting for medical use.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Stem cells for research; stem cells for scientific purposes; nutrition agents, namely, cell culture reagents for scientific and research use for processing living cells other than for medical purposes; cell culture media other than for medical purposes Pharmaceutical products for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns; pharmaceutical preparations for the treatment of Parkinson's disease and neurodegenerative diseases, heart failure, diabetes, Non-Alcoholic Steatohepatitis and acute liver failure, Age-related macular degeneration and limbal stem cells deficiencies, traumatic injury and skin burns; stem cells for medical or veterinary use; pluripotent stem cells for medical purposes intended for cell and gene therapies; cell culture media for cultivating human cells for medical or veterinary use; surgical implants comprised of living tissues obtained from stem cells Scientific apparatus, namely, cytometers and biomimetic 3D culture systems composed of cell culture dishes for cell culture systems; scientific apparatus, namely, laboratory pipettes and capsules for the analysis and sorting of cell culture; bioreactors for cell culture; observation apparatus, namely, microscopes for cell culture; incubators for cell culture; cell culture apparatus for laboratory use, namely, cell culture dishes and tissue culture flaks; downloadable software used for the collection, analysis, sorting, communication of biological information relating to stem cells Apparatus for the regeneration of stem cells for medical use; apparatus for cell culture systems for medical purposes, namely, cell culture chambers and capsules; apparatus for cell culture systems by encapsulation for medical purposes, namely, cell culture chambers and capsules; apparatus for analyzing and sorting cell culture for medical purposes, namely, cell culture chambers and capsules Laboratory research in the field of biotechnology; scientific research on stem cells; scientific research on the production of pluripotent stem cells by encapsulation; research and development in the field of stem cells, cell and gene therapy and biotechnology; pharmaceutical research and development; scientific laboratory services; providing informations with respect to scientific research in the field of stem cells, cell and gene therapy and biotechnology
