Abstract

Provided is a synthesis of cephalosporin derivatives, characterized by the use of the new intermediates for the preparation of cephalosporin derivatives, a crystalline toluene hemi-solvate of benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[4-pyridyl-2-thiazolylthio]-3-cephem-4-carboxylate, and a crystalline 4-[2-[[(6R,7R)-7-amino-2 carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]-thio]-4-thiazolyl]-1-methyl-pyridinium chloride, hydrochloride (1:1:1), obtained by a specific process and processes for preparation thereof.

IPC Classes  ?

• C07D 501/59 - Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Abstract

The present invention relates to a method for testing the sterility of a plant and/or production process by checking for the presence or absence of at least one microorganism.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/06 - Investigating concentration of particle suspensions
• C12Q 1/22 - Testing for sterility conditions