Abstract

The invention relates to a rodenticide bait by ingestion for at least one harmful target rodent ingesting this bait during an ingestion period, referred to as consumption period, imposed by virtue of said ingestion; the rodenticide bait comprising: a composition, referred to as AVK(s) composition, of at least one vitamin K recycling inhibitory compound; a composition, referred to as vitamin D composition, of at least one hypercalcaemic vitamin D, and; at least one edible excipient for harmful target rodents; characterised in that: said AVK(s) composition is present in the rodenticide bait in a non-zero mass proportion, referred to as AVK(s) proportion, which is non-lethal on its own to any harmful target rodent, and in that; said vitamin D composition is present in the rodenticide bait in a mass proportion, referred to as vitamin D proportion: sufficient for said vitamin D composition to be lethal on its own to at least one harmful target rodent, and; less than a minimum mass proportion sufficient for said vitamin D composition to be lethal on its own to any harmful target rodent. The invention also relates to the uses of a rodenticide bait according to the invention and to a method for controlling harmful target rodents.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 31/06 - Oxygen or sulfur directly attached to a cycloaliphatic ring system
• A01P 11/00 - Rodenticides

Abstract

The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, wherein the cellulose nanofibres are not TEMPO-oxidized cellulose nanofibers, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

4, the chromatographic analysis being performed at a temperature of 23.5° C.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography

Abstract

Disclosed is to a laevorotatory enantiomer of the configurational stereoisomer of difethialone, named hetero-stereoisomer, the formula of which is 3-(4′-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which carbons 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations.

IPC Classes  ?

• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography

Abstract

1, the analysis being performed at a temperature of 27.3° C.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• C07B 57/00 - Separation of optically-active organic compounds

Abstract

The present invention concerns an in vitro method for diagnosing a joint disease in a mammal and/or determining the type of joint disease and/or determining the stage of said disease and/or predicting the course of said disease, comprising the following steps: • a) depositing a drop of a synovial fluid sample from the mammal on a support plane made of an inorganic material, such as glass; • b) drying the drop that was deposited in step a); • c) measuring at least one parameter indicating morphological characteristics of the drop dried in step b), by which a value for said parameter is obtained, and • d) comparing each value measured in step c) with a reference value that is representative of a reference synovial fluid. Said parameter is chosen from among (i) the maximum height (H) of the bead formed on the surface of the drop, (ii) the surface area (S) of the drop and (iii) the surface profile (Z) of the drop. The value of the surface area (S) is representative of the concentration of hyaluronic acid present in a synovial fluid and the maximum height value (H) is representative of the concentration of proteins present in a synovial fluid.

IPC Classes  ?

• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 21/65 - Raman scattering

Abstract

The invention relates to a dextrorotatory enantiomer of the configurational stereoisomer of difethialone, referred to as a homo-stereoisomer, of formula 3-(4'-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group of said homo-stereoisomer have the same absolute configuration.

IPC Classes  ?

• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01P 11/00 - Rodenticides
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

The invention relates to a dextrorotatory enantiomer of a configurational stereoisomer of difethialone, referred to as a hetero-stereoisomer, of formula 3-(4'-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations.

IPC Classes  ?

• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

The invention relates to a levorotatory enantiomer of the configurational stereoisomer of difethialone, referred to as a hetero-stereoisomer, of formula 3-(4'-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations.

IPC Classes  ?

• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E1, of flocoumafen, said enantiomer E1 having, as determined by the chromatographic analysis of the flocoumafen, carried out under specific conditions, a retention time t1 with a value such that t1 < t2 < t3 < t4; t2, t3 and t4 representing the retention times of the configurational stereoisomers of flocoumafen different from said enantiomer E1, said analysis being carried out at a temperature of 23.5°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E3, of flocoumafen, said enantiomer E3 having, as determined by the chromatographic analysis of the flocoumafen, carried out under specific conditions, a retention time t3 with a value such that t1 < t2 < t3 < t4; t1, t2 and t4 representing the retention times of the configurational stereoisomers of flocoumafen different from said enantiomer E3, said analysis being carried out at a temperature of 23.5°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E2, of flocoumafen, said enantiomer E2 having, as determined by the chromatographic analysis of a flocoumafen composition comprising four configurational stereoisomers of flocoumafen, carried out under conditions described hereinafter, a retention time t2 with a value such that t1 < t2 < t3 < t4; t1, t3 and t4 representing the retention times of the configurational stereoisomers of flocoumafen different from said enantiomer E2, said chromatographic analysis being carried out at a temperature of 23.5°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• A01P 11/00 - Rodenticides

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E1, of bromadiolone, having, as determined by the chromatographic analysis of bromadiolone comprising four configurational stereoisomers of bromadiolone, carried out under conditions described hereinafter, a retention time t1 with a value such that t1 ឬ t2 ឬ t3 ឬ t4; t2, t3 and t4 representing the retention times of the configurational stereoisomers of bromadiolone different from said enantiomer E1, said analysis being carried out at a temperature of 27.3°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E4, of bromadiolone, having, as determined by the chromatographic analysis carried out under conditions described hereinafter, a retention time t4 with a value such that t1 ឬt2 ឬ t3 ឬ t4; t1, t2 and t3 representing the retention times of each configurational stereoisomer of bromadiolone different from said enantiomer E4, said analysis being carried out at a temperature of 27.3 °C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

The invention relates to a levorotatory enantiomer of the configurational stereoisomer of difethialone, referred to as a homo-stereoisomer, of formula 3-(4'-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have the same absolute configuration.

IPC Classes  ?

• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom

Abstract

The invention relates to a composition comprising diféthialone, characterised in that it contains a configurational stereoisomer of difethialone, referred to as a hetero-stereoisomer, of formula 3-(4'-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations, said composition comprising an amount of a dextrorotatory enantiomer of said hetero-stereoisomer such that the ratio of this amount to the amount of diféthialone in the composition is less than 10%; the amount of the dextrorotatory enantiomer of said hetero-stereoisomer of difethialone in the composition being different from the amount of levorotatory enantiomer of said hetero-stereoisomer of difethialone in the composition.

IPC Classes  ?

• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01P 11/00 - Rodenticides

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E4, of flocoumafen, said enantiomer E4 having, as determined by the chromatographic analysis of flocoumafen comprising four configurational stereoisomers of flocoumafen, carried out under conditions described hereinafter, a retention time t4 with a value such that t1 < t2 < t3 < t4; t1, t2 and t3 representing the retention times of the configurational stereoisomers of flocoumafen different from said enantiomer E4, said analysis being carried out at a temperature of 23.5°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

The invention relates to a composition comprising flocoumafen and an amount of a configurational stereoisomer, referred to as enantiomer E4, of flocoumafen, such that the ratio of this amount to the amount of flocoumafen in the composition is less than 10%, said enantiomer E4 being present to the exclusion of a racemic mixture, said enantiomer E4 having, as determined by the chromatographic analysis of flocoumafen, a retention time t4 with a value such that t1 ឬ t2 ឬ t3 ឬ t4; t1, t2 and t3 representing the retention times of the configurational stereoisomers of flocoumafen different from said enantiomer E4, the chromatographic analysis being conducted at a temperature of 23.5°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• A01P 11/00 - Rodenticides

Abstract

The invention relates to a configurational stereoisomer, referred to as enantiomer E3, of bromadiolone, having, as determined by the chromatographic analysis of a bromadiolone composition comprising four configurational stereoisomers of bromadiolone, carried out under conditions described hereinafter, a retention time t3 with a value such that t1 ឬ t2 ឬ t3 ឬ t4; t1, t2 and t4 representing the retention times of the configurational stereoisomers of bromadiolone different from said enantiomer E3, said analysis being carried out at a temperature of 27.3°C.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom