Cleerly, Inc.

United States of America

Back to Profile

1-100 of 146 for Cleerly, Inc. Sort by
Query
Aggregations
IP Type
        Patent 123
        Trademark 23
Jurisdiction
        United States 132
        World 11
        Canada 2
        Europe 1
Date
New (last 4 weeks) 2
2026 July 2
2026 June 4
2026 (YTD) 10
2025 20
See more
IPC Class
G06T 7/00 - Image analysis 118
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment 97
A61B 6/03 - Computed tomography [CT] 95
A61B 5/00 - Measuring for diagnostic purposes Identification of persons 88
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters 64
See more
NICE Class
42 - Scientific, technological and industrial services, research and design 23
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services 21
09 - Scientific and electric apparatus and instruments 1
Status
Pending 61
Registered / In Force 85
  1     2        Next Page

1.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19258599
Status Pending
Filing Date 2025-07-02
First Publication Date 2026-07-23
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

2.

PLAQUE BASED FFR

      
Serial Number 99946615
Status Pending
Filing Date 2026-07-17
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SaaS) services featuring software for generating, analyzing, and managing cardiovascular diagnostic aid, assessments, predictions, risk stratification, and reporting based on medical images; design, development, programming, updating, maintenance, and customization of cardiovascular medical imaging software, including platforms utilizing artificial intelligence and machine learning Providing software-based cardiovascular imaging aid services for medical purposes, including image-based cardiovascular examination, assessment, monitoring, reporting, triage, and risk evaluation to aid in diagnosis; providing cardiovascular medical imaging, screening, information, consultation, and advisory services, including the use of software or artificial intelligence to support and aid medical analysis and decision-making

3.

CLEERLY PLAQUE ANALYSIS

      
Serial Number 99868511
Status Pending
Filing Date 2026-06-05
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SaaS) services featuring software for generating, analyzing, and managing cardiovascular diagnostic aid, assessments, predictions, risk stratification, and reporting based on medical images; design, development, programming, updating, maintenance, and customization of cardiovascular medical imaging software, including platforms utilizing artificial intelligence and machine learning; and software as a service (SaaS) services for prioritizing or triaging cardiovascular imaging cases and managing related patient information Providing software-based cardiovascular imaging aid services for medical purposes, including image-based cardiovascular examination, assessment, monitoring, reporting, triage, and risk evaluation to aid in diagnosis; providing cardiovascular medical imaging, screening, information, consultation, and advisory services, including the use of software or artificial intelligence to support and aid medical analysis and decision-making

4.

PLAQUE+

      
Serial Number 99868541
Status Pending
Filing Date 2026-06-05
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SaaS) services featuring software for generating, analyzing, and managing cardiovascular diagnostic aid, assessments, predictions, risk stratification, and reporting based on medical images; design, development, programming, updating, maintenance, and customization of cardiovascular medical imaging software, including platforms utilizing artificial intelligence and machine learning; and software as a service (SaaS) services for managing cardiovascular imaging cases and related patient information Providing software-based cardiovascular imaging aid services for medical purposes, including image-based cardiovascular examination, assessment, monitoring, reporting, and risk evaluation to aid in diagnosis; providing cardiovascular medical imaging, screening, information, consultation, and advisory services, including the use of software or artificial intelligence to support and aid medical analysis and decision-making

5.

CLEERLY PLAQUE

      
Serial Number 99868523
Status Pending
Filing Date 2026-06-05
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SaaS) services featuring software for generating, analyzing, and managing cardiovascular diagnostic aid, assessments, predictions, risk stratification, and reporting based on medical images; design, development, programming, updating, maintenance, and customization of cardiovascular medical imaging software, including platforms utilizing artificial intelligence and machine learning; and software as a service (SaaS) services for prioritizing or triaging cardiovascular imaging cases and managing related patient information Providing software-based cardiovascular imaging aid services for medical purposes, including image-based cardiovascular examination, assessment, monitoring, reporting, triage, and risk evaluation to aid in diagnosis; providing cardiovascular medical imaging, screening, information, consultation, and advisory services, including the use of software or artificial intelligence to support and aid medical analysis and decision-making

6.

CLEERLY ED TRIAGE

      
Serial Number 99868532
Status Pending
Filing Date 2026-06-05
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SaaS) services featuring software for generating, analyzing, and managing cardiovascular diagnostic aid, assessments, predictions, risk stratification, and reporting based on medical images; design, development, programming, updating, maintenance, and customization of cardiovascular medical imaging software, including platforms utilizing artificial intelligence and machine learning; and software as a service (SaaS) services for prioritizing or triaging cardiovascular imaging cases and managing related patient information Providing software-based cardiovascular imaging aid services for medical purposes, including image-based cardiovascular examination, assessment, monitoring, reporting, triage, and risk evaluation to aid in diagnosis; providing cardiovascular medical imaging, screening, information, consultation, and advisory services, including the use of software or artificial intelligence to support and aid medical analysis and decision-making

7.

CLEERLY PREVIEW

      
Serial Number 99719469
Status Pending
Filing Date 2026-03-23
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

8.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19382050
Status Pending
Filing Date 2025-11-06
First Publication Date 2026-03-05
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

9.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19359247
Status Pending
Filing Date 2025-10-15
First Publication Date 2026-02-12
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

10.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19359416
Status Pending
Filing Date 2025-10-15
First Publication Date 2026-02-05
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

11.

CLEERLY CORONARY

      
Serial Number 99545433
Status Pending
Filing Date 2025-12-12
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; Software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

12.

CLEERLY LABS

      
Serial Number 99545440
Status Pending
Filing Date 2025-12-12
Owner CLEERLY, INC. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; Software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

13.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19237330
Status Pending
Filing Date 2025-06-13
First Publication Date 2025-11-13
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

14.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 19197638
Status Pending
Filing Date 2025-05-02
First Publication Date 2025-10-30
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

15.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

      
Application Number US2025025842
Publication Number 2025/226727
Status In Force
Filing Date 2025-04-22
Publication Date 2025-10-30
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Chan, Chung
  • Earls, James P.

Abstract

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 6/03 - Computed tomography [CT]

16.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

      
Application Number 19186433
Status Pending
Filing Date 2025-04-22
First Publication Date 2025-10-23
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Chan, Chung
  • Earls, James P.

Abstract

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
  • G06T 7/60 - Analysis of geometric attributes
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

17.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19210802
Status Pending
Filing Date 2025-05-16
First Publication Date 2025-10-09
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

18.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 19219477
Status Pending
Filing Date 2025-05-27
First Publication Date 2025-09-11
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 40/14 - Vascular patterns

19.

SYSTEMS, METHODS, AND DEVICES FOR IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18652770
Status Pending
Filing Date 2024-05-01
First Publication Date 2025-07-03
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Chan, Chung
  • Rodrigues Marques, Hugo Miguel
  • Ronen, Shai
  • Wang, Hao

Abstract

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/02 - Arrangements for diagnosis sequentially in different planesStereoscopic radiation diagnosis
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/766 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using regression, e.g. by projecting features on hyperplanes
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

20.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18508098
Status Pending
Filing Date 2023-11-13
First Publication Date 2025-05-08
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earis, James P.
  • Marques, Hugo Miquel Rodriques
  • Chan, Chung
  • Crabtree, Tami
  • Nieslanik, Nicholas Michael

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

21.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 18940602
Status Pending
Filing Date 2024-11-07
First Publication Date 2025-04-17
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

22.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 18990200
Status Pending
Filing Date 2024-12-20
First Publication Date 2025-04-17
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 40/14 - Vascular patterns

23.

SYSTEMS AND METHODS FOR CHARACTERIZING HIGH RISK PLAQUES

      
Application Number 18905755
Status Pending
Filing Date 2024-10-03
First Publication Date 2025-04-17
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • G06T 7/00 - Image analysis

24.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 18989916
Status Pending
Filing Date 2024-12-20
First Publication Date 2025-04-17
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 40/14 - Vascular patterns

25.

CLEERLY

      
Application Number 019167508
Status Registered
Filing Date 2025-04-03
Registration Date 2025-08-07
Owner Cleerly, Inc. (USA)
NICE Classes  ? 42 - Scientific, technological and industrial services, research and design

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans.

26.

CLEERLY

      
Serial Number 99088493
Status Pending
Filing Date 2025-03-17
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

27.

COMPARE

      
Serial Number 99042498
Status Pending
Filing Date 2025-02-14
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular diagnostics aid based on medical images and machine learning; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

28.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18669263
Grant Number 12396695
Status In Force
Filing Date 2024-05-20
First Publication Date 2025-01-23
Grant Date 2025-08-26
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

29.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 18774735
Status Pending
Filing Date 2024-07-16
First Publication Date 2025-01-16
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

30.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18591778
Grant Number 12440180
Status In Force
Filing Date 2024-02-29
First Publication Date 2025-01-02
Grant Date 2025-10-14
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Rodrigues Marques, Hugo Miguel

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

31.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18593121
Status Pending
Filing Date 2024-03-01
First Publication Date 2024-12-26
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

32.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18593210
Status Pending
Filing Date 2024-03-01
First Publication Date 2024-12-26
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

33.

SYSTEMS, METHODS, AND DEVICES FOR IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number US2024027316
Publication Number 2024/229165
Status In Force
Filing Date 2024-05-01
Publication Date 2024-11-07
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Chan, Chung
  • Ronen, Shai
  • Wang, Hao
  • Rodrigues Marques, Hugo Miguel

Abstract

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

IPC Classes  ?

  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

34.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18641232
Grant Number 12178627
Status In Force
Filing Date 2024-04-19
First Publication Date 2024-09-19
Grant Date 2024-12-31
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

35.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18670506
Grant Number 12171606
Status In Force
Filing Date 2024-05-21
First Publication Date 2024-09-19
Grant Date 2024-12-24
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

36.

Systems, methods, and devices for image-based plaque analysis and risk determination

      
Application Number 18674711
Grant Number 12380560
Status In Force
Filing Date 2024-05-24
First Publication Date 2024-09-19
Grant Date 2025-08-05
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/02 - Arrangements for diagnosis sequentially in different planesStereoscopic radiation diagnosis
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/766 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using regression, e.g. by projecting features on hyperplanes
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

37.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18629673
Grant Number 12156759
Status In Force
Filing Date 2024-04-08
First Publication Date 2024-08-22
Grant Date 2024-12-03
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

38.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18612734
Grant Number 12193862
Status In Force
Filing Date 2024-03-21
First Publication Date 2024-08-15
Grant Date 2025-01-14
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06V 40/14 - Vascular patterns
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

39.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18612980
Grant Number 12245882
Status In Force
Filing Date 2024-03-21
First Publication Date 2024-08-08
Grant Date 2025-03-11
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/04 - Positioning of patientsTiltable beds or the like
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 40/14 - Vascular patterns

40.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614580
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

41.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614586
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

42.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614597
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

43.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614605
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

44.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18591726
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-08-08
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

45.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18586145
Grant Number 12141976
Status In Force
Filing Date 2024-02-23
First Publication Date 2024-08-08
Grant Date 2024-11-12
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations

46.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18592081
Grant Number 12599352
Status In Force
Filing Date 2024-02-29
First Publication Date 2024-08-08
Grant Date 2026-04-14
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

47.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18593171
Status Pending
Filing Date 2024-03-01
First Publication Date 2024-08-08
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

48.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614592
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

49.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614595
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-08-08
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

50.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18444339
Grant Number 12324696
Status In Force
Filing Date 2024-02-16
First Publication Date 2024-08-01
Grant Date 2025-06-10
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Crabtree, Tami

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

51.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18525434
Grant Number 12097063
Status In Force
Filing Date 2023-11-30
First Publication Date 2024-08-01
Grant Date 2024-09-24
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

52.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18593412
Status Pending
Filing Date 2024-03-01
First Publication Date 2024-08-01
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

53.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614601
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-07-11
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

54.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614602
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-07-11
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

55.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614603
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-07-11
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

56.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614588
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-07-11
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

57.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18614590
Status Pending
Filing Date 2024-03-22
First Publication Date 2024-07-11
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

58.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18457197
Grant Number 12558048
Status In Force
Filing Date 2023-08-28
First Publication Date 2024-07-04
Grant Date 2026-02-24
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 40/14 - Vascular patterns

59.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18531500
Grant Number 12299885
Status In Force
Filing Date 2023-12-06
First Publication Date 2024-06-27
Grant Date 2025-05-13
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

60.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number US2023085115
Publication Number 2024/137796
Status In Force
Filing Date 2023-12-20
Publication Date 2024-06-27
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

61.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18390555
Status Pending
Filing Date 2023-12-20
First Publication Date 2024-06-27
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G06T 7/60 - Analysis of geometric attributes
  • G06V 20/50 - Context or environment of the image
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

62.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18591954
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

63.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18592175
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

64.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18592253
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

65.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18592038
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

66.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18592039
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

67.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18592103
Status Pending
Filing Date 2024-02-29
First Publication Date 2024-06-20
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

68.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18592176
Grant Number 12635965
Status In Force
Filing Date 2024-02-29
First Publication Date 2024-06-20
Grant Date 2026-05-26
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

69.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18444367
Grant Number 12144669
Status In Force
Filing Date 2024-02-16
First Publication Date 2024-06-13
Grant Date 2024-11-19
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

70.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18586224
Grant Number 12283046
Status In Force
Filing Date 2024-02-23
First Publication Date 2024-06-13
Grant Date 2025-04-22
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations

71.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number US2023079590
Publication Number 2024/107691
Status In Force
Filing Date 2023-11-14
Publication Date 2024-05-23
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Chan, Chung
  • Nieslanik, Nicholas Michael
  • Crabtree, Tami
  • Rodrigues Marques, Hugo Miguel
  • Earls, James P.

Abstract

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

72.

CLEERLY ADVANCED PLAQUE ANALYSIS

      
Serial Number 98529099
Status Pending
Filing Date 2024-05-01
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular analysis based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular analysis based on medical images and machine learning; cardiovascular medical image processing software design; updating of cardiovascular medical image processing software; software as a service (SAAS) services featuring software for controlling and managing cardiovascular analyses; computer software design; computer software development; software design and development; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans; computer software design, computer programming, and maintenance of computer software; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans based on machine learning; Image-based cardiovascular analysis services for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services for medical diagnostic and treatment purposes; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services for medical diagnostic and treatment purposes; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

73.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18458498
Grant Number 12023190
Status In Force
Filing Date 2023-08-30
First Publication Date 2024-02-22
Grant Date 2024-07-02
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06T 7/00 - Image analysis
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

74.

Systems and methods for characterizing high risk plaques

      
Application Number 18446822
Grant Number 12138093
Status In Force
Filing Date 2023-08-09
First Publication Date 2024-01-25
Grant Date 2024-11-12
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

IPC Classes  ?

  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • G06T 7/00 - Image analysis

75.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18457050
Status Pending
Filing Date 2023-08-28
First Publication Date 2023-12-28
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

76.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18456707
Status Pending
Filing Date 2023-08-28
First Publication Date 2023-12-28
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

77.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number 18456341
Status Pending
Filing Date 2023-08-25
First Publication Date 2023-12-14
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

78.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18456329
Grant Number 12620092
Status In Force
Filing Date 2023-08-25
First Publication Date 2023-12-14
Grant Date 2026-05-05
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis

79.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18454462
Grant Number 11922627
Status In Force
Filing Date 2023-08-23
First Publication Date 2023-12-07
Grant Date 2024-03-05
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

80.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18454364
Grant Number 11948301
Status In Force
Filing Date 2023-08-23
First Publication Date 2023-12-07
Grant Date 2024-04-02
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

81.

Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

      
Application Number 18179921
Grant Number 12406365
Status In Force
Filing Date 2023-03-07
First Publication Date 2023-09-14
Grant Date 2025-09-02
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • G06T 7/12 - Edge-based segmentation
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

82.

SYSTEMS, DEVICES, AND METHODS FOR NON-INVASIVE IMAGE-BASED PLAQUE ANALYSIS AND RISK DETERMINATION

      
Application Number US2023063972
Publication Number 2023/172970
Status In Force
Filing Date 2023-03-08
Publication Date 2023-09-14
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Malkasian, Shant
  • Rodrigues Marques, Hugo Miguel
  • Chan, Chung
  • Ronen, Shai

Abstract

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 8/08 - Clinical applications
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06T 7/00 - Image analysis

83.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18149014
Grant Number 12555228
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-07-27
Grant Date 2026-02-17
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations

84.

CLEERLY RULE OUT

      
Serial Number 98078376
Status Pending
Filing Date 2023-07-10
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Software as a service (SAAS) services featuring software for generating cardiovascular analysis based on medical images; software as a service (SAAS) services featuring software for generating cardiovascular analysis based on medical images and machine learning; cardiovascular medical image processing software design; updating of cardiovascular medical image processing software; software as a service (SAAS) services featuring software for controlling and managing cardiovascular analyses; computer software design; computer software development; software design and development; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans; computer software design, computer programming, and maintenance of computer software; software as a service (SAAS) services featuring software for cardiovascular imaging, namely, for interpreting the results of cardiovascular medical imaging scans based on machine learning; Web-based cardiovascular analysis services of images for medical diagnostic and treatment purposes; cardiovascular analysis testing, monitoring, and reporting services; cardiovascular analysis for diagnostic or treatment purposes; cardiovascular image analysis services; cardiovascular medical information; cardiovascular medical screening; cardiovascular medical advisory services; providing cardiovascular medical information

85.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18149021
Grant Number 11690586
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-18
Grant Date 2023-07-04
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 8/14 - Echo-tomography
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61K 49/04 - X-ray contrast preparations
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 40/14 - Vascular patterns

86.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148995
Grant Number 11967078
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-18
Grant Date 2024-04-23
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing

87.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148712
Grant Number 11766230
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-11
Grant Date 2023-09-26
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 8/14 - Echo-tomography
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image

88.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148985
Grant Number 12499539
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-11
Grant Date 2025-12-16
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 8/14 - Echo-tomography
  • A61K 49/04 - X-ray contrast preparations

89.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148249
Grant Number 11737718
Status In Force
Filing Date 2022-12-29
First Publication Date 2023-05-11
Grant Date 2023-08-29
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 8/14 - Echo-tomography
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image

90.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148345
Grant Number 11730437
Status In Force
Filing Date 2022-12-29
First Publication Date 2023-05-11
Grant Date 2023-08-22
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 8/14 - Echo-tomography
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image

91.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148697
Grant Number 11766229
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-11
Grant Date 2023-09-26
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 8/14 - Echo-tomography
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image

92.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18149006
Grant Number 11861833
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-11
Grant Date 2024-01-02
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 8/14 - Echo-tomography
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing

93.

Systems and methods for characterizing high risk plaques

      
Application Number 18148296
Grant Number 11751831
Status In Force
Filing Date 2022-12-29
First Publication Date 2023-05-04
Grant Date 2023-09-12
Owner Cleerly, Inc. (USA)
Inventor Min, James K.

Abstract

A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • G06T 7/00 - Image analysis

94.

Systems and methods for characterizing high risk plaques

      
Application Number 18148309
Grant Number 11642092
Status In Force
Filing Date 2022-12-29
First Publication Date 2023-05-04
Grant Date 2023-05-09
Owner CLEERLY, INC. (USA)
Inventor Min, James K.

Abstract

A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • G06T 7/00 - Image analysis

95.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18148347
Grant Number 11672497
Status In Force
Filing Date 2022-12-29
First Publication Date 2023-05-04
Grant Date 2023-06-13
Owner CLEERLY. INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • A61B 8/14 - Echo-tomography
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image

96.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number 18149017
Status Pending
Filing Date 2022-12-30
First Publication Date 2023-05-04
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Malkasian, Shant
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 8/14 - Echo-tomography
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61K 49/04 - X-ray contrast preparations
  • G06F 18/10 - Pre-processingData cleansing

97.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18149020
Grant Number 11779292
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-04
Grant Date 2023-10-10
Owner Cleerly, Inc. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 8/14 - Echo-tomography
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61K 49/04 - X-ray contrast preparations
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 40/14 - Vascular patterns

98.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

      
Application Number 18149025
Grant Number 11832982
Status In Force
Filing Date 2022-12-30
First Publication Date 2023-05-04
Grant Date 2023-12-05
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Rodrigues Marques, Hugo Miguel
  • Hootnick, Ben

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 8/14 - Echo-tomography
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61K 49/04 - X-ray contrast preparations
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • G06F 18/10 - Pre-processingData cleansing
  • G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/20 - Image preprocessing
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 40/14 - Vascular patterns

99.

CLEERLY

      
Application Number 1719212
Status Registered
Filing Date 2022-11-10
Registration Date 2022-11-10
Owner Cleerly, Inc. (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing online non-downloadable software for generating cardiovascular diagnostics and predictions based on medical images for use in the fields of heart disease, cardiology, and cardiovascular medicine via a website; providing temporary use of online non-downloadable software for generating cardiovascular diagnostics and predictions based on medical images for use in the fields of heart disease, cardiology, and cardiovascular medicine; providing quality assurance services in the fields of heart disease, cardiology, and cardiovascular medicine. Medical and medical clinical services in the fields of heart disease, cardiology, and cardiovascular medicine; providing information in the fields of heart disease, cardiology, and cardiovascular medicine via a website; providing information in the fields of heart disease, cardiology, and cardiovascular medicine.

100.

SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING

      
Application Number US2022040816
Publication Number 2023/023286
Status In Force
Filing Date 2022-08-18
Publication Date 2023-02-23
Owner CLEERLY, INC. (USA)
Inventor
  • Min, James K.
  • Earls, James P.
  • Marques, Hugo Miguel Rodrigues
  • Malkasian, Shant

Abstract

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 8/08 - Clinical applications
  • A61B 6/03 - Computed tomography [CT]
  1     2        Next Page