Abstract

Provided is the use of quercetin-3'-O-β-D-glucoside as a calcium channel inhibitor, which belongs to the medical field. Also provided is the use of the quercetin-3'-O-β-D-glucoside in the preparation of a drug for treating cardiovascular diseases, coronary heart disease, atherosclerosis, advanced renal failure, neurological diseases, chronic pain, acute pain or inflammatory diseases. The present invention demonstrates that the quercetin-3'-O-β-D-glucoside can inhibit a calcium channel, especially the TRPC ion channel, and expands the use of the quercetin-3'-O-β-D-glucoside.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

An application of an Abelmoschi Corolla extract in preparation of a drug for inhibiting a calcium channel and treating a calcium channel-mediated disease. The disease is a cardiovascular disease, coronary heart disease, atherosclerosis, end-stage renal failure, a neurological disorder, chronic pain, acute pain, or an inflammatory disease. The Abelmoschi Corolla extract contains, by weight, at least one of 0.2% or more of quercetin-3-O-robinoside, 0.5% or more of isoquercitrin, and 0.5% or more of quercetin-3'-O-β-D-glucoside.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A substituted crotonamide pharmaceutical composition and a preparation method therefor. The pharmaceutical composition comprises 5-50 parts of (E)-N-(3-cyano-7-ethoxy-4-(3-ethynylphenylamino)quinoline-6-yl)-4-(dimethylamino)butyl-2-enamide maleate, 40-120 parts of a filler, 2-20 parts of a disintegrant, 0-6 parts of an adhesive, and 0.5-5 parts of a lubricant. The filler is selected from carbohydrates.

IPC Classes  ?

• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 9/20 - Pills, lozenges or tablets
• A61P 35/00 - Antineoplastic agents

Abstract

An application of a substituted crotonamide, in particular being an application of (E)-N-(3-cyano-7-ethoxyl-4-(3-ethynylphenylamino)quinoline-6-yl)-4-(dimethylamino)but-2-enamide and a pharmaceutically acceptable salt and solvate thereof in the preparation of a drug for treating cancer mediated by a rare EGFR mutation.

IPC Classes  ?

• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• C07D 215/54 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
• A61P 35/00 - Antineoplastic agents

Abstract

Provided is the use of an Abelmoschi corolla extract in the preparation of a drug for treating fibrosis, wherein the extract contains at least 15% of gossypetin-3-O-β-D-glucose-8-O-β-D-glucuronide, with same being prepared by means of the following method: taking medicinal materials of Abelmoschi corolla, heating same with ethanol and performing reflux extraction, performing filtration, concentrating the filtrate, and carrying out macroporous resin column chromatography, where same is firstly washed with water, then eluting same with 3-7% of ethanol, eluting same with 9-15% of ethanol, and collecting 9-15% of an ethanol eluent in order to obtain the Abelmoschi corolla extract.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61K 133/00 - Containing or obtained from flowers or blossoms

Goods & Services

Tonics [medicines]; medicines for human purposes; nutritive substances for microorganisms; vitamin preparations; disinfectants; pharmaceutical preparations; bacteriological preparations for medical and veterinary use; contact lens cleaning preparations; therapeutic preparations for the bath.

Abstract

Disclosed are a total flavone extract of Abelmoschus Manihot and the preparation method thereof. The weight ratio of Gossypetin-3'-glucoside : Quercetin-3'-glucoside : Isoquercetin is (11-16) : (2.5-6) : (4-6.5) in the extract.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61K 133/00 - Containing or obtained from flowers or blossoms