A structure of an asymmetric supercapacitor and a preparation method thereof is disclosed. In some implementations, the preparation comprises the steps of forming a polyaniline (PANI) nanowire on carbon cloth (CC) substrate (PANI/CC) by polymerization of an aniline, depositing a cobalt-nickel layer double hydroxides (CoNi-LDHs) on the PANI/CC by a hydrothermal process, and calcining of the cobalt-nickel layer double hydroxides (CoNi-LDHs) in the PANI/CC at a high temperature to form a metal carbide (CoC@NiC) on the carbon cloth. The structure of the asymmetric supercapacitor includes a metal carbide (CoC@NiC) as a positive electrode, a tungsten trioxide (WO3@C) as a negative electrode, and a poly (vinyl alcohol)/Potassium hydroxide (PVA/KOH) as an electrolyte gel.
The present disclosure provides a method for biomarker analysis. More particularly, provided herein is a method for identifying biomarker(s) associated with mental health disorder(s) such as but not limited to Major Depressive Disorder (MDD). The said method of the present disclosure is based on an integrative analysis between machine learning and bioinformatics techniques. The method allows efficient mining of publicly available datasets pertaining to mental health disorder patients to identify biomarkers that can aid in the diagnosis and prediction of the onset of such mental health disorders. Further envisaged herein are the biomarker(s) identified by the said method which allow early and efficient detection of mental health disorder(s) by non-invasive methods and application(s) of such biomarker(s).
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
An aptamer-based biosensor for detecting SARS-COV-2 in symptomatic and asymptomatic patients capable of onsite testing of large-scale population of up to 96 people at once providing fast and reliable results. The present invention relates to a novel aptamer-based biosensor for the rapid and reliable detection of SARS-COV-2 viral proteins in nasopharyngeal swabs of suspected individuals with COVID-19.
Novel pyridopyridine derivative compounds, methods of preparing the compounds, pharmaceutical compositions comprising one or more such compounds, and methods of treatment of diseases associated with protein kinases.
The invention discloses a thermal management device for high heat flux application in a microelectronic device comprising an integrated board, a microelectronic chip, a thermal interface materials component, a microchannel heat sink assembly operatively connected to the thermal interface materials component, for heat dissipation from the integrated board and the microelectronic chip to the thermal interface materials component, wherein the microchannel heat sink assembly comprises a housing and an adiabatic wall configured to allow heat to pass across the microchannel heat sink assembly. The microchannel heat sink assembly is a four-compartment microchannel heat sink assembly with symmetrical areas.
H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
H01L 21/48 - Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups or
H01L 23/00 - Details of semiconductor or other solid state devices
8.
Particle-based energy dissipation device for structures
An energy dissipation device is disclosed. The device includes a container, where the container includes a top plate that is horizontally slotted on the container. In addition, the device includes at least one movable plate is inserted through a slot inside the container, and at least two holes inserted in the at least one movable plate. Moreover, the device includes at least two rods partially threaded at both sides of the container. In some implementations, the device may include a frame. In addition, the device includes a damper fixed inside the frame, and a plurality of braces installed in the frame to provide support to the damper. Moreover, the device includes at least one beam and at least one horizontal plate fixed to a bottom face of the at least one beam. A method of assembling an energy dissipation device is also disclosed.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04B 1/36 - Bearings or like supports allowing movement
Novel SARS-CoV-2 inhibitors with dual targeting activity against both the viral RdRp and Mpro and host TMPRSS2 protease for therapeutic formulations and methods for treating SARS-CoV-2 infections. The present disclosure, in some embodiments, provides novel compounds with dual targeting activity against SARS-CoV-2. The compounds selectively target the viral RdRp and Mpro enzymes and host TMPRSS2 protease.
A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
The present invention relates to a smart knowledge-based waste collection system and method for monitoring and collecting waste of an area by optimizing a dynamic waste collection route by analyzing actual and historical waste generation data of the waste bin to forecast volume of daily waste generated, prioritizing the waste bin to be serviced if a volume of daily waste of the waste bin predicted is larger than bin capacity, assigning waste bin and real-time traffic data to the route optimization module to compute the dynamic waste collection route and transmitting the optimized route to the autonomous vehicle to collect the waste from the waste bins to be serviced.
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
12.
Integrated thermal management system with a symmetrical supercapacitor cell
A symmetrical supercapacitor cell is disclosed comprising at least two electrode split sections, at least two electrodes, a plurality of ring isolators, and a spring pin arrangement. The at least two electrodes are placed in between the at least two electrode split sections, wherein a plurality of ring isolators is connected with a plurality of bolts to fasten the at least two electrode split sections. Also disclosed is an integrated thermal management system with a supercapacitor cell including a base support holder, a heating coil casing, a heating coil, and a cavity. The heating coil is installed inside the heating coil casing that is underneath a supercapacitor cell body. Further, a cavity is formed around the supercapacitor cell and contains an oil that is heated via the installed heating coil to achieve a desired temperature.
H01G 11/18 - Arrangements or processes for adjusting or protecting hybrid or EDL capacitors against thermal overloads, e.g. heating, cooling or ventilating
H01G 11/28 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features arranged or disposed on a current collectorLayers or phases between electrodes and current collectors, e.g. adhesives
13.
ENERGY DISSIPATION DEVICE FOR STRUCTURES AND EQUIPMENT
The present disclosure relates to an energy dissipation device and system, comprising a hollow cylinder adapted to be filled with solid balls, and a longitudinal member/shaft having short rods protruding radially therefrom. The shaft having rods is movably disposed of within the hollow member and solid balls are filled and secured in the cylinder thereafter, such that two ends of the longitudinal member extend outside of the hollow member, and the rods and solid balls remain within the hollow cylinder. The ends of the device may be configured with structures or equipment. The movement of the shaft along a longitudinal axis of the cylinder, upon receiving an energy impact in an event of seismic activity, wind loads, and/or man-made vibrations, results in friction between the solid balls and the rods of the shaft, which facilitates dissipation of the received energy.
F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system
F16F 7/01 - Vibration-dampersShock-absorbers using friction between loose particles, e.g. sand
14.
DCT-based watermarking scheme for deep neural networks
The invention discloses a DNN watermarking method, comprising embedding part of the digital watermark in selected redundant elements of a deep neural network (DNN) model—without compromising the performance of the DNN. The proposed method aims for a robust watermark scheme by embedding a large watermark that can span the whole DNN model. If an adversary attempts to destroy the watermark, the whole DNN model will be destroyed. However, maximizing the hiding capacity can lead to degradation in the performance of the DNN model. In this work, this capacity-performance trade-off problem is solved using the Discrete Cosine Transform (DCT). Moreover, the DCT can work more efficiently with highly correlated data. Therefore, this work suggests segmenting the weights of the DNN model into correlated segments to fully exploit the advantages of the DCT.
G06F 21/16 - Program or content traceability, e.g. by watermarking
15.
Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof
The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
This invention relates to a method (30) and system (10) for evaluating circuit protection of a power network. The method (30) includes simulating (32) a multisource, interconnected power network (40) comprising circuit protection elements (A, B, C, D), setting (33) circuit protection element parameters for each circuit protection element, simulating (35) at least one fault (42) on the power network (40) at a predetermined fault position for a predefined simulation time. In a next step, the method includes calculating (38) conductor LTE exposure and determining (39) an LTE threshold. Furthermore, the method (30) includes simultaneously graphically representing (41) a three-dimensional visualisation of the conductor LTE exposure (50) for the predefined simulation time and the LTE threshold (51), on the same three-dimensional visualisation. The method provides a wholistic approach for simulating and determining a dynamic effect of faults for chosen circuit protection settings on conductor LTE exposure compared to LTE thresholds.
G06F 30/367 - Design verification, e.g. using simulation, simulation program with integrated circuit emphasis [SPICE], direct methods or relaxation methods
17.
BIOMARKERS FOR CEREBRAL METABOLIC DISORDERS, AND DIAGNOSTIC METHODS USING THEREOF
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITY OF SHARJAH (United Arab Emirates)
Inventor
Mabondzo, Aloïse
Broca-Brisson, Léa
Costa, Narciso
Guyot, Anne-Cécile
Armengaud, Jean
Hamoudi, Rifat
Harati, Rania
Abstract
The disclosure relates to a method for diagnosing a cerebral creatine deficiency syndrome, the method comprising the steps of a) measuring an amount of at least one protein selected from BDNF, KIF1 A, MeCP2, PLCB1, and a combination thereof, in an isolated biological sample, and b) comparing the measured amount obtained at step a) with a predetermined reference amount of said protein, where a difference between the measured amount and the predetermined reference amount is indicative of a cerebral creatine deficiency syndrome in said individual. The disclosure also relates to at least one protein selected from BDNF, KIF1A, MeCP2, PLCB1, and a combination thereof, as a biomarker for use in a method for diagnosing a cerebral creatine deficiency syndrome.
A system and a method for smart information recognition for user health identification are disclosed. The system and the method comprise a display unit, a color code detection unit, an image filter, an optical character recognition unit, a code detection unit and an elimination unit. The display unit contains a user information. The color code detection unit is associated with the display unit to split at least one of the user information by analyzing at least three colors in an image. The image filter detects at least one of the user's information. Further, the optical character recognition unit recognizes a text of the user information. The code detection unit detects an image code and the elimination unit is used for eliminating a binary object that is close to an image border. The proposed system and method ensure complete security to prevent abuse of an individual's personal information.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G06V 30/18 - Extraction of features or characteristics of the image
19.
4N particles in nitrogen-doped carbon nanosheets for hybrid supercapacitors
The present disclosure provides a cooling system facilitating thermal management in a solar photovoltaic (PV) module. The cooling system includes an exhaust fan, operatively coupled to an outlet of a central air conditioning module, the outlet carries waste air from the central air conditioning module. A supporting structure is placed at a predefined distance in front of the exhaust fan to support one or more solar panels. The one or more solar panels are tilted at a predefined angle and a predefined azimuth configured to provide maximum surface area of the back units of the one or more solar panels. The exhaust fan is further configured to direct the waste air and surrounding air towards the back units of the one or more solar panels at a predefined temperature.
H01G 11/30 - Electrodes characterised by their material
H01G 11/86 - Processes for the manufacture of hybrid or EDL capacitors, or components thereof specially adapted for electrodes
H01G 11/24 - Electrodes characterised by structural features of the materials making up or comprised in the electrodes, e.g. form, surface area or porosityElectrodes characterised by the structural features of powders or particles used therefor
Provided is a fixture for automatic assembly, overturning and welding of sidewall aluminum profile of a rail vehicle, comprising a lifting mechanism, a supporting overturning device mounted on the lifting mechanism, an automatic assembling sidewall profile device mounted on the supporting overturning device, and a self-positioning locking device. The automatic assembling sidewall profile device comprises a sidewall-shaped support steel beam, and a rodless cylinder track platform and a fixing seat. The self-positioning locking devices are mounted on the rodless cylinder track platform and the fixing seat, and have a self-positioning base and a locking device. The self-positioning base comprises an outer housing is provided with the locking device and two symmetrically set self-positioning supports, and faces of the two self-positioning supports matching with the rail vehicle aluminum profile are provided with rollers having a V-shaped gap formed therebetween.
B23K 37/04 - Auxiliary devices or processes, not specially adapted for a procedure covered by only one of the other main groups of this subclass for holding or positioning work
B23K 101/00 - Articles made by soldering, welding or cutting
B23K 37/00 - Auxiliary devices or processes, not specially adapted for a procedure covered by only one of the other main groups of this subclass
23.
Full-automatic wheel hub three-dimensional scanning system for intelligent production lines of automotive wheel hub
Provided a full-automatic wheel hub 3D scanning system for intelligent production line of automotive wheel hubs, comprising: a base plate is provided with an X-directional displacement control device and a Y-directional displacement control device; a roller-table assembly is arranged on the base plate and comprises a roller table, wherein the roller table is provided with an opposite-type photoelectric sensors and a wheel hub centring positioning device for centring positioning a wheel hub; a 3D scanning device, comprising a mounting bracket, wherein the bottom of the mounting bracket is controlled by the Y-directional displacement control device; a 3D scanner is mounted on the mounting bracket; a wheel hub scanning platform is arranged at an end of the roller-table assembly and is controlled by the X-directional displacement control device; and a robot is arranged on a first side of the wheel hub scanning platform, for conveying the wheel hubs after 3D scanning.
An apparatus for thaw detection of a frozen item is disclosed, the apparatus comprising a housing container comprising a first transparent section and a second opaque section, at least one low density floating object and at least one high density object both encased within the housing container, wherein the housing container is filled with a filling mixture and melting of the filling mixture results in the at least one low density floating object and at least one high density object to be visible in the first transparent section of the housing container, thereby enabling thaw detection of the frozen item. Also disclosed is a method of manufacturing an apparatus for thaw detection of a frozen item.
The present invention discloses novel SARS-CoV-2 inhibitors for therapeutic formulations and methods for treating SARS-CoV-2 infections. The compounds exhibit unique pharmacophoric features including conformational flexibility and spatial orientation within the binding sites of the targeted proteases. The present invention also discloses methods for treating SARS-CoV-2 infections, comprising administering to the subject in need thereof a therapeutically effective amount of the compound, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutical excipients.
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
26.
DISCOVERY OF ANTI-SARS-COV-2 INHIBITORS BY DUAL VIRAL-HOST TARGETING
The present invention discloses novel SARS-CoV-2 inhibitors for therapeutic formulations and methods for treating SARS-CoV-2 infections. The compounds exhibit unique pharmacophoric features including conformational flexibility and spatial orientation within the binding sites of the targeted proteases. The present invention also discloses methods for treating SARS-CoV-2 infections, comprising administering to the subject in need thereof a therapeutically effective amount of the compound, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutical excipients.
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
27.
Discovery of imidazothiazole- and imidazooxazole-based selective HER4 kinase inhibitors as potential anticancer agents
Novel first-in-class imidazothiazole- and imidazooxazole-based potent and selective HER4 kinase inhibitors for therapeutic formulations and methods for treating cancer.
This invention relates to a method (30) and system (10) for evaluating circuit protection of a power network. The method (30) includes simulating (32) a multisource, interconnected power network (40) comprising circuit protection elements (A, B, C, D), setting (33) circuit protection element parameters for each circuit protection element, simulating (35) at least one fault (42) on the power network (40) at a predetermined fault position for a predefined simulation time. In a next step, the method includes calculating (38) conductor LTE exposure and determining (39) an LTE threshold. Furthermore, the method (30) includes simultaneously graphically representing (41) a three-dimensional visualisation of the conductor LTE exposure (50) for the predefined simulation time and the LTE threshold (51), on the same three-dimensional visualisation. The method provides a wholistic approach for simulating and determining a dynamic effect of faults for chosen circuit protection settings on conductor LTE exposure compared to LTE thresholds.
G06F 30/367 - Design verification, e.g. using simulation, simulation program with integrated circuit emphasis [SPICE], direct methods or relaxation methods
G06F 30/31 - Design entry, e.g. editors specifically adapted for circuit design
G06F 119/02 - Reliability analysis or reliability optimisationFailure analysis, e.g. worst case scenario performance, failure mode and effects analysis [FMEA]
G06F 119/06 - Power analysis or power optimisation
29.
Method of measuring impedance using Gaussian white noise excitation
G01R 27/16 - Measuring impedance of element or network through which a current is passing from another source, e.g. cable, power line
G01R 27/04 - Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant in circuits having distributed constants
30.
Conformationally-restricted analogues of sorafenib and regorafenib as selective kinase inhibitors for cancer treatment
Novel conformationally-restricted analogues of sorafenib and regorafenib as selective kinase inhibitors for therapeutic formulations and methods for treating cancer.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
There is provided novel anticancer and antibacterial compounds, pharmaceutically acceptable salts thereof, and processes for their preparation. The compounds have anticancer activity, which results in the reduction of tumour cell proliferation, enhances cancers cells apoptosis and regulation of iron signalling. The compounds are also particularly active against various Gram-negative and Gram-positive multidrug-resistant bacteria, such as extended-spectrum beta-lactamase (ESBL) producing and colistin-resistant Escherichia coli, carbapenem-resistant E. coli, carbapenem-resistant Acinetobacter baumannii, and methicillin-resistant Staphylococcus aureus (MRSA) including those with reduced susceptibility to many control antibiotics.
A compound represented by following formula I:
according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
C07D 491/147 - Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
C07D 513/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or in which the condensed system contains four or more hetero rings
34.
A SOLAR PHOTOVOLTAIC PANEL FOG/MIST COOLING SYSTEM
The application discloses a solar photovoltaic panel fog/mist cooling system which comprises at least one solar photovoltaic panel (101), and at least one nozzle (110) arranged at a back side of the at least one solar photovoltaic panel (101) and configured to generate a fog/mist applied onto a back side of the at least one solar photovoltaic panel (101).
There is provided a solar photovoltaic panel fog/mist cooling system which comprises at least one solar photovoltaic panel, and at least one nozzle arranged at a back side of the at least one solar photovoltaic panel and configured to generate a fog/mist applied onto a back side of the at least one solar photovoltaic panel.
F25B 19/04 - Machines, plants or systems, using evaporation of a refrigerant but without recovery of the vapour using fluid jet, e.g. of steam using liquid jet, e.g. of water
36.
Small molecule inhibitors of fungal hyphae and biofilm formation
Novel compounds having inhibitory activity on the formation of fungal hyphae and biofilms, and therapeutic formulations and methods based on the novel inhibitors.
Novel compounds having inhibitory activity on the formation of fungal hyphae and biofilms, and therapeutic formulations and methods based on the novel inhibitors.
The invention provides an identification system for ascertaining who is at risk of haying or already has asthma or severe asthma. The system is based upon transcriptomic expression data from RNA extracted from saliva, blood, sputum, bronchial brush, and biopsies samples as well as optionally demographic, risk factor, and symptom data. Also provided are related materials and methods, including such as primers and kits.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
39.
DIAGNOSTIC AND PROGNOSTIC LIQUID BIOPSY BIOMARKERS FOR ASTHMA
The invention provides an identification system for ascertaining who is at risk of having or already has asthma or severe asthma. The system is based upon transcriptomic expression data from RNA extracted from saliva, blood, sputum, bronchial brush, and biopsies samples as well as optionally demographic, risk factor, and symptom data. Also provided are related materials and methods, including such as primers and kits.
There is provided a needle tip for extracting separated endodontic instruments from the root canal of a tooth. The needle tip is fabricated with a thermomechanically treated alloy exhibiting both shape memory and super-elasticity. There is also provided for a needle that includes a handle and a terminal tip, which is fabricated with a thermomechanically treated alloy. The alloy is thermomechanically treated nickel- titanium alloy. The needle is straight at room temperature and takes on a specific shape when inserted in the canal of the tooth from which the endodontic separated instrument is to be extracted. Also provided herein is a method for removal of endodontic separated instruments from the canal of a tooth.
The present invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes and intermediates for the manufacture of these novel constrained cyclic frameworks of general formula I and II, and medicaments containing such compounds.
C07D 513/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or in which the condensed system contains four or more hetero rings
Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
C07D 513/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or in which the condensed system contains four or more hetero rings
C07D 513/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or in which the condensed system contains four or more hetero rings
A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) of improved formulation in a sublingual dosage form and methods for therapeutic use of the AS RDSTs for treatment of organophosphate (OP) exposure and acute toxicity. The AS RDSTs provide an alternative easy-to-use dosage form for the management of organophosphate toxicity. Additionally, the invention provides methods for improved formulation and quality evaluation of the atropine sulfate rapidly-disintegrating sublingual tablets.
A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF ACUTE ORGANOPHOSPHATE TOXICITY
The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) in a sublingual dosage form and methods for therapeutic use of the AS RDSTs for treatment of organophosphate (OP) exposure and acute toxicity. The AS RDSTs provide an alternative easy-to-use dosage form for the management of organophosphate toxicity. Additionally, the invention provides methods for formulation and quality evaluation of the atropine sulfate rapidly-disintegrating sublingual tablets.
patents
