A preservation solution for corneal tissues in vitro comprises
between approximately 0.05% and approximately 15% by weight/volume of a culture medium for biological tissues,
between approximately 0.05 and approximately 20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 20000 and 550000 Dalton, preferably between 30000 and 200000 Dalton,
and between approximately 0.05% and approximately 5% by weight/volume of at least one nutrient protein, said at least one protein being of foetal or embryonic animal origin,
said preservation solution being suitable for preserving the corneal tissues at a temperature between approximately +2° C. and approximately +37° C. and for a preservation period up to 4 weeks, maintaining the vitality of the corneal cells in a substantially unchanged state and the corneal thickness in a substantially physiological state during the preservation period at a temperature between approximately +2° C. and approximately +37° C.
A preservation solution for corneal tissues in vitro includes:
approximately 0.05%-15% by weight/volume of a culture medium for biological tissues,
approximately 0.05%-20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 5000 and 550000 Dalton, and
approximately 0.05%-5% by weight/volume of at least one nutrient protein, which is a uniquely synthetic origin.
A preservation solution for corneal tissues in vitro includes:
approximately 0.05%-15% by weight/volume of a culture medium for biological tissues,
approximately 0.05%-20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 5000 and 550000 Dalton, and
approximately 0.05%-5% by weight/volume of at least one nutrient protein, which is a uniquely synthetic origin.
The preservation solution being suitable for preserving the corneal tissues at a temperature between approximately +2° C. and approximately +37° C. and for a preservation period up to 4 weeks, maintaining the vitality of the corneal cells in a substantially unchanged state and the corneal thickness in a substantially physiological state during the preservation period at temperatures between approximately +2° C. and approximately +37° C.
A tablet containing at least amphotericin B deoxycholate, a substance with lubricating properties, a substance with disaggregating properties and a substance with aggregating properties, the tablet being usable in a device for preserving harvested corneas, in combination with a bottle (2) equipped with an openable and reclosable cap (7), where the bottle contains a sterile preserving liquid (3) having a pH of between 7.2 and 7.6 and wherein the tablet can be completely dissolved; in accordance with the method claimed, a harvested cornea being preservable in the preserving liquid in which the tablet has been dissolved, for up to at least 15 days at a temperature of between 2° C. and 10° C.
C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
4.
CHEMICAL PREPARATION AND METHOD FOR THE DETECTION OF A RADICAL ACTIVITY
A chemical preparation for use in a method for the treatment of the bodies of humans or animals, or for use in a diagnostic method applied to the bodies of humans or animals, such that it has a behaviour that means that when, in the presence of a predetermined quantity of crystalline lens proteins with a weight/volume concentration preferably equal to 0.15%, the chemical preparation is subjected to: - either in vivo to one or more steps of said method for the treatment of the bodies of humans or animals or of said diagnostic method applied to the bodies of humans or animals; - or in vitro or ex vivo to one or more steps that reproduce steps of said method for the treatment of the bodies of humans or animals or of said diagnostic method applied to the bodies of humans or animals; the quantity of crystalline lens proteins present is reduced at most by a reduction quantity that, as an absolute value by weight, is equal to 40% of the predetermined quantity of crystalline lens proteins.
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
5.
VISCOELASTIC PREPARATION FOR USE IN SURGICAL METHODS OF OHPHTALMIC SURGERY
A viscoelastic preparation for use in methods for the treatment of the bodies of humans or animals, in particular for use as a hydrating and protective substance for the cornea during a surgical method of ophthalmic surgery, in which preparation forms a protective layer on the cornea and guarantees an optical enlargement effect of the visual field observable through the cornea; the preparation comprises a water-based phosphate buffer and, as a weight/volume percentage, at least: - at least one polymer for increasing the viscosity selected from the group comprising hydroxypropyl methylcellulose HPMC, carboxymethylcellulose, hydroxyethylcellulose, hyaluronic acid, sodium alginate, hydroxypropylguar polyvinylpyrrolidone, polyvinyl alcohol, polymethacrylic acid, copolymer with polyoxyethylene-polyoxypropylene and polyethylene glycol in a quantity of between 0.2% and 20%; - xanthan gum in a quantity of between 0.01 % and 1 %; - carrageenan in a quantity of between 0.005% and 0.5%.
A dye molecule having the structure (I): where R1 is an SO3 - group bound to a hydrogen H atom or to another atom or to an ammonium NH4 group or to a lysine salt or to an arginine salt or to a different monovalent cation, and R2 is an SO3- group, in particular for making dye preparations for use in methods for the treatment of the bodies of humans or animals, for example for dyeing the internal limiting membrane ILM and/or epiretinal membranes EPRM in a surgical method which involves subsequent removal respectively of the ILM and/or of the EPRM; as well as a dye preparation having a density higher than 1.01 g/cm3 and comprising at least one dye and at least one agent for increasing its density which is a polymer with the empirical formula (C12H22O11·C3H5ClO)n, and structure (II).
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals for use in industry, in particular silicones,
hydrocarbons and mixtures thereof; chemicals for
ophthalmology; fluorinated compounds, preferably in
ultrapure form, fluorinated silicones, fluorinated
hydrocarbons and mixtures thereof, hydrophilised and
lipophilised silicones, hydrophylised hydrocarbons and all
mixtures of the aforesaid silicones; silicones and
hydrocarbons and mixtures with further chemicals;
semi-fluorinated alkanes, liquid perfluorocarbons, standard
and heavy silicone oils; liquid and gaseous endotamponades
for use in ophthalmology; colorants and tissue colorants for
use in ophthalmology; ultrapure chemicals and mixtures
thereof, ultrapure liquids; ultrapure chemicals and mixtures
thereof for storing organs, tissues and cells; ultrapure
chemicals and mixtures thereof for washing and
decontaminating organs, tissues and cells. Pharmaceutical products; preparations for ophthalmology,
ophthalmological medicines, pharmaceutical solutions for use
in ophthalmology, pharmaceutical preparations for the
treatment of eye disorders, ophthalmological solutions for
use as auxiliary preparations during eye surgery; liquids
for use in ophthalmology; medicated products for use in
ophthalmology; sanitary preparations in connection with
ophthalmology; compositions containing active ingredients
for ophthalmology; liquid endotamponades for medical
purposes. Instruments, equipment and apparatus used in ophthalmology,
in particular for eye surgery; systems of ophthalmological
equipments consisting of the aforesaid instruments,
equipment and apparatus and system components.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
[ Chemicals for use in industry, namely, dimethyl siloxane trimethyl siloxy-terminated, hydrocarbons and mixtures thereof; chemicals used in the manufacture of ophthalmic pharmaceutical preparations, namely, fluorinated compounds in ultrapure form, fluorinated hydrocarbons and mixtures thereof; hydrocarbons for use in the manufacture of medical devices for ophthalmic surgery; chemicals used in industry, namely, semi-fluorinated alkanes, liquid perfluorocarbons, standard and heavy silicone oils; chemicals used in industry, namely, liquid and gaseous endotamponades for use in manufacturing ophthalmic pharmaceutical preparations; ultrapure chemicals and ultrapure liquid chemicals for use in industry; all the aforesaid goods used in the manufacture of pharmaceutical products and medical devices for use with respect to ophthalmic surgery ] Pharmaceutical preparations for use in ophthalmology; ophthalmological medicines, pharmaceutical preparations for the treatment of eye disorders, ophthalmological pharmaceutical solutions for use as auxiliary preparations during eye surgery; liquid pharmaceutical preparations for use in ophthalmology; medicated eye care preparations for use in ophthalmology; sanitary preparations for ophthalmological medical use; compositions, namely, drug delivery agents in the form of powders that provide controlled release of the active ingredients for a wide variety of pharmaceuticals [ ; liquid endotamponades, namely, fluorinated gases, perfluorocarbons, dimethyl siloxane trimethyl siloxy terminated for medical purposes ] [ Medical apparatus and instruments for use in ophthalmologic surgery ]
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for use in manufacturing, In particular hydrocarbons and mixtures thereof; Chemicals for use in ophthalmology; Fluorinated compounds, preferably in ultrapure form, fluorinated hydrocarbons and mixtures thereof; Hydrocarbons and mixtures with other chemicals; Semi-fluorinated alkanes, liquid perfluorocarbons, standard and heavy silicone oils; Internal tamponade fluids and gases for use in ophthalmology; Ultrapure chemicals and mixtures thereof, ultrapure liquids; Ultrapure chemical substances and mixtures thereof for preserving organs, tissues and cells; Ultrapure chemical substances and mixtures thereof for washing and decontaminating of organs, tissues and cells; All of the aforesaid goods relating to ophthalmic surgery. Pharmaceutical preparations; Ophthalmology preparations, ophthalmological medicines, pharmaceutical solutions for use in ophthalmology, pharmaceutical preparations for treating eye disorders, ophthalmological solutions for use as auxiliary preparations during eye surgery; Liquids for use in ophthalmology; Medical preparations for use in ophthalmology; Sanitary preparations relating to ophthalmology; Compositions containing active ingredients for ophthalmology; Internal tamponade fluids for medical purposes; Colorants and colorants for tissues for use in ophthalmology (preparations for ophthalmology). Instruments, equipment and apparatus used in ophthalmology, in particular for eye surgery; Ophthalmological equipment systems consisting of the aforesaid instruments, equipment and apparatus and system components.
10.
FLUOROALKYLOXY ALKANES, PROCESS FOR PRODUCTION AND USES THEREOF
The present invention relates to fluoroalkyloxy alkanes having formula (I) : RF-R1-O-R2 wherein: RF is a linear or branched perf luoroalkyl group, having from 1 to 12, preferably from 2 to 8, carbon atoms; R1 is a linear or branched, non-fluorinated alkylene group, having from 1 to 6, preferably from 2 to 4, carbon atoms,- R2 is a linear or branched, non-f luorinated alkyl group, having from 1 to 12, preferably from 2 to 8, carbon atoms, possibly containing at least one ether bond -O- along the chain. The present invention further relates to a process for preparation and use thereof, possibly in mixture with at least one silicone oil, as medicaments in ophthalmology, in particular as tamponade liquids in an operation for the treatment of retinal detachment.
A device for ophthalmic treatments comprises a package (9) forming a housing chamber (9a) inside it, and a syringe (2) inserted in the housing chamber (9a) and filled with a sterile liquid, of the type which can be injected into an eyeball. The liquid (4) is selected from amongst the family of perfluorocarbons. There are also two methods for making the device (1).
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61K 9/00 - Medicinal preparations characterised by special physical form
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
25 - Clothing; footwear; headgear
Goods & Services
Bleaching preparations and other substances for laundry use;
cleaning, polishing, scouring and abrasive preparations;
soaps; perfumery, essential oils, cosmetics, hair lotions;
dentifrices. Paper, cardboard and goods made from these materials, not
included in other classes; printed matter; bookbinding
material; photographs; stationery; adhesives for stationery
or household purposes; artists' materials; paint brushes;
typewriters and office requisites (except furniture);
instructional and teaching material (except apparatus);
plastic materials for packaging (not included in other
classes); printers' type; printing blocks. Leather and imitations of leather, and goods made of these
materials and not included in other classes; animal skins,
hides; trunks and travelling bags; umbrellas, parasols and
walking sticks; whips, harness and saddlery. Clothing, footwear, headgear.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
25 - Clothing; footwear; headgear
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Paper, cardboard and goods made from these materials, not included in other classes; printed matter; bookbinding material; photographs; stationery; adhesives for stationery or household purposes; artists' materials; paint brushes; typewriters and office requisites (except furniture); instructional and teaching material (except apparatus); plastic materials for packaging (not included in other classes); printers' type; printing blocks. Leather and imitations of leather, and goods made of these materials and not included in other classes; animal skins, hides; trunks and travelling bags; umbrellas, parasols and walking sticks; whips, harness and saddlery. Clothing, footwear, headgear.
