A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.
F04B 9/12 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air
G01N 30/14 - Preparation by elimination of some components
B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
2.
6-acetylmorphine analogs, and methods for their synthesis and use
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
A61K 39/385 - Haptens or antigens, bound to carriers
C07D 489/02 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07D 489/00 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum
C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Control preparations for in vitro diagnostic testing, screening, confirmation and analysis; diagnostic reagents and chemical reagents, for laboratory or research use; solutions used in diagnostic test kits, for laboratory or research use; diagnostic test kits for laboratory use; diagnostic preparations for laboratory use; diagnostic test kits comprising reagents and assays.
(2) Medical diagnostic test kits; medical diagnostic reagents; diagnostic preparations for medical purposes; testing preparations for medical use; diagnostic tests for medical use; medical diagnostic assays; solutions used in medical diagnostic test kits; cartridges containing reagents for medical diagnostic test use; cartridges containing medical diagnostic reagents; test cartridges containing chemical reagents for in vitro diagnostic medical testing; medical reagents contained in a cartridge for medical diagnostic use.
(3) In vitro medical diagnostic instruments; in vitro medical diagnostic instruments for lipid testing; medical diagnostic blood testing instruments; medical diagnostic glucose testing instruments; medical diagnostic instruments for testing cholesterol; medical diagnostic instruments for therapeutic monitoring of heart disease and diabetes; test cassettes for use in relation to all the aforementioned goods.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Control preparations for in vitro diagnostic testing, screening, confirmation and analysis; diagnostic reagents and chemical reagents, for laboratory or research use; solutions used in diagnostic test kits, for laboratory or research use; diagnostic test kits for laboratory use; diagnostic preparations for laboratory use; diagnostic test kits comprising reagents and assays. Medical diagnostic test kits; medical diagnostic reagents; diagnostic preparations for medical purposes; testing preparations for medical use; diagnostic tests for medical use; medical diagnostic assays; solutions used in medical diagnostic test kits; cartridges containing reagents for medical diagnostic test use; cartridges containing medical diagnostic reagents; test cartridges containing chemical reagents for in vitro diagnostic medical testing; medical reagents contained in a cartridge for medical diagnostic use. In vitro medical diagnostic instruments; in vitro medical diagnostic instruments for lipid testing; medical diagnostic blood testing instruments; medical diagnostic glucose testing instruments; medical diagnostic instruments for testing cholesterol; medical diagnostic instruments for therapeutic monitoring of heart disease and diabetes; test cassettes for use in relation to all the aforementioned goods.
5.
2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
C07D 207/20 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A61K 39/385 - Haptens or antigens, bound to carriers
C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
G01N 33/94 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving narcotics
C07D 207/267 - 2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 39/00 - Medicinal preparations containing antigens or antibodies
6.
DETECTION OF RECOMBINASE POLYMERASE AMPLIFICATION USING DUAL-HAPTEN PROBE
This disclosure relates to methods and compositions for detecting a target nucleic acid sequence using a dual-hapten probe. More specifically, the present disclosure relates to using recombinase polymerase amplification (RPA) and a dual-hapten probe to detect a target nucleic acid sequence. In some cases, the detection is on lateral flow strips.
C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.
F04B 9/12 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air
F04B 13/00 - Pumps specially modified to deliver fixed or variable measured quantities
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
9.
2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE
The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
C07D 207/02 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D 207/18 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
The present invention relates to novel 2-ethylidene-l,5-dimethyl-3,3-diphenylpyrrolidine analogs: and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
C07D 207/02 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D 207/18 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
A61K 39/385 - Haptens or antigens, bound to carriers
C07D 489/02 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
C07D 489/00 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
A flu assay system including a sample module, a microfluidic nucleic acid amplification device, and an analyzer to facilitate fully automated nested recombinase polymerase amplification (RPA) on a sample delivered to the nucleic acid amplification device via the sample module. The assay includes providing a sample to a microfluidic device, and amplifying a target polynucleotide sequence in the sample. Amplifying the target polynucleotide sequence includes performing a first round of amplification on the sample to yield a first amplification product, and performing a second round of amplification on the first amplification product to yield a second amplification product. The second amplification product includes a smaller sequence completely contained within the first amplification product produced during the first round of amplification.
This invention relates to sequence specific electrochemically-labeled oligonucleotide probes for the detection of nucleic acids and methods associated therewith.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
A61K 39/385 - Haptens or antigens, bound to carriers
C07D 489/02 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07D 489/00 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum
C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
The present invention provides for a home test assay or device that can calculate insulin on board levels, and uses thereof for improving insulin bolus calculation and prevention of hypoglycemia in e.g. Type-1 diabetes patients.
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
C07D 489/00 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
C07D 489/02 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol.
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Drug testing kits comprised of medical diagnostic reagents and assays for testing body fluids; drug testing kits comprised of medical diagnostic reagents and assays that test for the presence of drugs and alcohol
33.
METHODS FOR DIAGNOSING AND PROGNOSING PLACENTAL DYSFUNCTION AND PRE-ECLAMPSIA
Provided herein are methods for determining placental dysfunction in a female suspected of having placental dysfunction or preclampsia by assessing the expression of P1GF in a biological sample of a female patient who is less than 35 weeks pregnant. Also described herein are methods for assigning a prognosis for a future complication associated with pregnancy in a female suspected of having placental dysfunction who is less than 35 weeks pregnant. The invention further relates to methods of managing and mitigating risks of pregnant females suspected of having placental dysfunction or pre-eclampsia to monitor the health and well-being of the baby and mother. Said methods can be used at the time of initial assessment for suspected placental dysfunction or pre-clampsia to identify a group of pregnant females with a placental dysfunction or pre-eclampsia, and to determine the potential to develop any complications of placental dysfunction or pre-eclampsia. Therefore, methods not only are able to provide very useful prognostic information for patients but also can help clinicians to select a candidate pregnant female likely to benefit from early and aggressive pre-eclampsia therapy.
The present invention relates to methods for joining materials as well as articles manufactured using such processes. The invention pertains to a process for joining a first substrate to a second substrate. The process includes irradiating a portion of a first substrate with a laser beam having a first wavelength and intensity sufficient to increase the absorbance of the first substrate to light having a second, different wavelength. The laser beam may carbonize at least a portion of the irradiated portion of the first substrate imparting a higher absorbance to light than non-irradiated portions of the first substrate. A second substrate is then placed in contact with the irradiated portion of the first substrate. The first substrate is then irradiated with a second laser having a second wavelength, different to the first wavelength; with a sufficient intensity to heat and, preferably melt, the irradiated portion of the first substrate.
A combination of capillary forces and gas pressure is used to control the movement of liquid samples within a microfluidic device. A liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action partway along the capillary channel. As the liquid sample moves, a pressure of a gas acting upon a distal gas-liquid interface of the liquid sample increases by an amount sufficient to stop further movement of the liquid sample. To initiate further movement of the liquid sample, a pump connected to a distal portion of the capillary channel decreases the pressure of the gas acting upon the distal gas-liquid interface of the liquid sample by an amount sufficient to permit the liquid sample to move by capillary action further along the capillary channel of the microfluidic device.
A microfluidic pump is provided for managing fluid flow in disposable assay devices, which provides constant flows even at very low flow rates. Devices utilizing the microfluidic pump, as well as methods for manufacture and performing a microfluidic process are also provided.
The invention encompasses diagnosis and prognosis in the context of heart or renal failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The invention also relates to methods of assigning an increased likelihood that a subject having CKD is susceptible to CKD progression. The invention relates in part to assigning a diagnosis of heart and/or renal failure, and/or an outcome risk (e.g., worsening cardiac and/or renal function or a mortality risk) to a subject based, at least in part, on the result(s) obtained from an assay that detects WAP four-disulfide core domain protein 2 performed on a body fluid sample obtained from a subject..
The present invention relates to novel 2-hydroxyhippuric acid analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or functional moiety such as a free thiol (-SH) group or a protected thiol group, thereby providing a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Diagnostic preparations for medical purposes, specifically in vitro diagnostic immunoassay systems and components thereof for determining the presence of drugs of abuse in fluid and/or tissues samples of human subjects.
41.
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS IN GASTRIC CANCER
The present invention relates to methods for diagnosing gastric cancer; methods for assigning risk of reoccurrence of gastric cancer; methods for assigning risk of mortality due to gastric cancer, methods of monitoring gastric cancer; methods of staging gastric cancer; and various devices and kits adapted to perform such methods. These methods comprise measurement of Trefoil factor (1) and optionally Anterior gradient protein (2) homolog on a body fluid sample obtained from a subject.
The present invention provides methods and compositions for monitoring of subjects suffering from, or being evaluated for, heart failure. A filtered Natriuretic peptide time-series, alone or in combination with other clinical indicia such as weight gain, can be used to estimate a patient's hazard (risk of decompensation). The cumulative integral of Natriuretic peptide concentration can be used to estimate cumulative hazard (risk times exposure) over longer periods of exposure, e.g., 14 day periods, or 30 day periods.
The invention encompasses diagnosis and prognosis in the context of heart or renal failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The invention also relates to methods of assigning an increased likelihood that a subject having AKI is susceptible to AKI progression. The invention relates in part to assigning a diagnosis of heart and/or renal failure, and/or an outcome risk (e.g., worsening cardiac and/or renal function or a mortality risk) to a subject based, at least in part, on the result(s) obtained from an assay that detects WAP four-bisulfide core domain protein 2 performed on a body fluid sample obtained from a subject.
A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
A method includes contacting a crude matrix with components of an isothermal nucleic acid amplification reaction for a target nucleic acid species, thereby providing a mixture; incubating the mixture under conditions sufficient for the isothermal nucleic acid amplification reaction to proceed, thereby providing a product; and determining whether an indicator of the target nucleic acid species is present in the product.
This disclosure describes kits, reagents and methods for Recombinase Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed kits, reagents and methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods.
The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
The present invention relates to methods for the diagnosis and evaluation of BNP- related diseases. In particular, patient test samples are analyzed for the presence and amount of a plurality of natriuretic peptides, and a combined natriuretic peptide result is used as a diagnostic marker.
An assay device and method for measuring the concentration of LDL-associated cholesterol in a blood-fluid sample are described. The method employs selective precipitation of VLDL and chylomicrons and immunoseparation of HDL from a blood fluid sample. The assay device allows the assay to be performed entirely in a flow strip format.
An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design is such that removal of non-HDL lipoproteins from a sample and assay of HDL cholesterol in the sample occur without interruption of the assay. The device also prevents interference by reagents used for the HDL assay with other assays carried out on the same sample.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Reagents for use in scientific and/or medical research uses, namely antibodies, fluorescent compounds for use as detectable labels, immunoassay standards, and buffer solutions Biological reagents, namely antibodies for medical and veterinary diagnostic and therapeutic use in a wide variety of illnesses and diseases Laboratory analyte testing apparatuses, namely fluorometers, immunoassay devices, pipets, and electronic storage media containing encoded testing parameters, for detection of drugs of abuse, microbes, and markers related to a wide variety of illnesses and diseases Medical diagnostic testing apparatuses, namely fluorometers, immunoassay devices, and electronic storage media containing encoded testing parameters, for detection of drugs of abuse, microbes, and markers related to a wide variety of illnesses and diseases Scientific and medical research services, namely generation of antibodies and antibody expression libraries, diagnostic assay design and development, and identification and validation of diagnostic and therapeutic targets
55.
Automated immunoassay cassette, apparatus and method
An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement toward and away from a sample transfer position. Sample supplied to a sample well in the cassette body is taken up by a reagent reservoir containing a first reagent composition effective to form a modified sample. The support provides a reagent strip having a transfer zone that is brought into contact with the reservoir, when the support is in the transfer position, a detection zone located downstream of the transfer zone, and a second reagent composition effective to react with the modified sample to form a detectable analyte-dependent product. By controlling movement of the support, volume and rate of sample flow from the reservoir to the strip can be controlled to optimize and/or standardize sample-transfer conditions in the assay.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
laboratory devices for scientific research use in analyzing the composition of the biological samples for determining the presence or amount of markers related to the cardiovascular diseases in humans [ and non-human animals ] medical devices for analyzing the composition of human [ and veterinary ] clinical samples, namely, determining the presence or amount of markers related to heart disease
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Diagnostic test kits comprising reagents and reagent vesicles for performing diagnostic test assay.
(2) Diagnostic test devices and kits comprising pipette for performing diagnostic test assay.
(3) Diagnostic test devices and kits comprising support device for performing diagnostic test assay. (1) Diagnostic marker discovery, namely analytical laboratory testing services for the purpose of identifying diagnostic genetic markers; laboratory testing services, namely, immunoassay-based drug testing services.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical, veterinary and sanitary substances; infants' and invalids' foods; plasters, material for bandaging; material for stopping teeth, dental wax; disinfectants; preparations for killing weeds and destroying vermin; diagnostic reagents for in vivo use. Surgical, medical, dental and veterinary instruments and apparatus , artificial limbs, eyes and teeth; orthopedic articles; suture materials; blood testing apparatus; blood drawing apparatus; blood coagulation monitoring, measuring or analysis apparatus; hemostatis monitoring, measuring or analysis apparatus. Medical, hygienic and beauty care; pharmaceutical, scientific, medical and industrial research; laboratory services; veterinary and agricultural services; consultancy, design, testing, and advisory services in the fields of medicine, surgery, diagnosis, pharmaceuticals, hospitals and patient care; information and advisory services relating to the aforesaid, including the provision of information relating to the aforesaid on-line from a computer network or via the interner.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemicals for use in science and scientific research; reagents and other chemicals which detect immune complexes in body fluids for scientific or research use; immunodiagnostic assay test kits containing such chemicals. Pharmaceutical and veterinary preparations; chemical and diagnostic reagents for medical or veterinary use. Scientific apparatus and instruments; laboratory apparatus and instruments; test tubes, pipettes and immunoassay diagnostic slides.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Laboratory diagnostic test kits containing antibodies, reagents, reagent vesicles, support racks, and pipettes; laboratory analyte testing apparatus, namely test kits for detection of abused drugs and metabolites thereof. (1) Research and consultation services in biotechnology and laboratory services, namely assay design, purification, processing and development of diagnostics and the products of biotechnology.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
medical laboratory diagnostic test kits containing antibodies, reagents, reagent vesicles, support racks, and pipettes laboratory analytical testing apparatus for detection of abused drugs
(1) In vitro medical diagnostic equipment, namely, printers.
(2) In vitro medical diagnostic equipment, namely, photometers, disposable test cassettes, collection tubes and pipettes, and kits containing the above goods, carrying cases.
(3) In vitro medical diagnostic equipment, namely, instruction manuals.
physician (and allied health care professionals) office system for monitoring blood lipids, comprising a photometer, disposable test cassettes and blood collection accessories
