Methods and systems are provided for security patch type detection of software patches. A software patch for a software product may be received. For example, the software patch may be received by a computing device. A pre-patch code property graph and a post-patch code property graph may be determined. For example, the pre-patch code property graph and the post-patch code property graph may be determined based on the software patch and/or the pre-patch source code and the post-patch source code respectively. A combined patch code property graph may be determined. For example, the combined patch code property graph may be determined based on the pre-patch code property graph and the post-patch code property graph. A patch type for the software patch may be determined. For example, the patch type may be determined based on the combined patch code property graph and/or a machine-learning prediction model.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
Detection of behavior anomalies in control systems and related systems. methods. and devices is disclosed. A method of detecting behavior anomalies in a control system includes probing emanations from a processor controlling at least a portion of the control system to provide an emanations signal. amplifying the emanations signal to provide an amplified emanations signal. and sampling the amplified emanations signal using a sampling rate that is greater than a clock frequency of a processor clock of the processor to provide samples. The method also includes determining whether or not the processor is exhibiting a behavior anomaly responsive to the samples.
A method of performing prioritized remediation for a distributed system includes: obtaining cyber security; outputting a standard security weakness ranking based on the cyber security data; determining that one or more vulnerabilities exist in one or more system components of the distributed system based on the standard security weakness ranking; customizing metrics for calculating an exploitation likelihood and an exposure factor associated with a vulnerability based on a user input including at least one variable influencing the likelihood or the exposure factor and capturing a specific applicative domain of each vulnerability, priorities of the system, types of potential attackers; calculating the customized metrics; outputting a customized ranking of the one or more vulnerabilities based on the calculation; and performing a prioritized remediation of a target vulnerability selected by the user based on the customized ranking and specific needs and resources of the system.
A system for gait-based user authentication, includes a processor and a memory. The memory includes instructions stored thereon, which when executed by the processor, cause the system to: access data relating to a gait of a user; provide the data as an input to an early escape network (EENet) having two or more early exits; dynamically determine by a deep Q-learning network (DQN) which of the two or more early exits of the EENet to take; dynamically determine by the EENet a predicted authentication at the determined exit; take the determined early exit by the EENet; and provide an authentication based on the predicted authentication at the determined early exit.
A method, system and apparatus provides detection of malicious network traffic by analyzing, via a trained machine learning model, at least timing and flow duration features of extracted from monitored network traffic, the at least timing and flow duration features independent of content of the monitored network traffic; and predicting, via the trained machine learning model, from the analyzed at least timing and flow duration features that a cyber-attack has occurred or is occurring.
Disclosed are rechargeable, organic, potassium ion batteries suitable for use at high temperatures and in a variety of applications that require thermally stable batteries (e.g., well drilling, electric vehicles, military applications, among others).
Embodiments relate to novel pan caspase inhibitors and method of manufacture of the same. Additionally, embodiments provide pharmaceutical compositions using novel pan caspase inhibitors, and methods for the use thereof as caspase inhibitors and for the treatment of disorders caused by excessive apoptotic activity.
A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/5025 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
8.
ULTRASOUND-RESPONSIVE AQUEOUS TWO-PHASE MICROCAPSULE DESIGN FOR ON-DEMAND PULSATILE DRUG RELEASE
The Trustees of Columbia University in the City of New York (USA)
George Mason University (USA)
Inventor
Sia, Samuel K.
Field, Rachel D.
Jakus, Margaret A.
Chitnis, Parag V.
Abstract
An aqueous biphasic microcapsule comprising a core comprising a payload-containing polymer and a shell encapsulating the core, the shell comprising a photopolymerized polymer, wherein the payload-containing polymer and photopolymerized polymer are phase separated, and methods of production and use.
A method and system disable executable script in requested displayable content. Responsive to requesting displayable content, a non-executable code sequence and a mis-matched font file that maps a plurality of characters of the requested displayable content to the non-executable code sequence is received. The non-executable code sequence is displayed as a text string in accordance with the received mis-matched font file.
Ultrasound devices including wearable, patch-type ultrasound devices, which feature a porous graphene electrode prepared by graphitization of a polyimide precursor.
Embodiments relate to peptides that binds with molecules of programmed death protein-1 (PD-1) to form a complex that modulate release of an inflammatory cytokine from a cell. Peptides are PD-1 agonists used to treat an inflammatory disease.
A processing-in-memory (PIM) system includes a plurality of PIM clusters interconnected by a router in one or more dynamic random-access memory (DRAM) banks. The PIM clusters include one or more multiply and accumulate (MAC) processing elements including a plurality of MAC lookup table cores operatively configured to perform arithmetic logic, and one or more special function (SF) processing elements, wherein the one or more SF processing elements including a plurality of SF lookup table cores operatively configured to perform one or more machine learning activation functions. The MAC lookup tables include a first arithmetic logic unit (ALU) lookup table core type operatively configured to perform addition or multiplication operations, and a second ALU lookup table core type operatively configured to simultaneously perform both addition and multiplication operations. The MAC lookup table cores and SF lookup table cores are configured to perform convolutional neural network acceleration.
A method, system and apparatus provides network communication between a sender and a receiver in a communication network. At a sender side of the network communication a ciphertext is encoded into a stegotext in a target language using a randomized language model, the ciphertext based upon an original content in a source language. The stegotext randomly generated by the language model to be decoupled from the original content and to have an assigned context in the target language that corresponds to the network communication in the target language. The stegotext is transmitted to a receiver over multiple communication channels of a communication network using one or more applications on an application layer of the communication network.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
14.
LOCAL AREA INTEGRATED DRONE, AIRCRAFT, VEHICLE, AND ASSET MANAGEMENT SYSTEM
Methods, systems, and apparatuses are described for local area integrated drone, aircraft, vehicles, and asset management. A computing device may receive data from drones, aircrafts, vehicles, and assets, and may perform tracking, registration, planning, deconfliction, and safety monitoring for the local area integrated drone, aircraft, vehicles, and asset management.
Laser fabricated graphene fiber which can be prepared from a fluorinated polyimide fiber is disclosed. The graphene fiber exhibits an ultrahigh specific surface area, facilitating excellent electrochemical properties, useful for example in tranducers, capacitors, and micro-supercapacitors.
D01F 9/24 - Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C08G 73/10 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
D01D 5/00 - Formation of filaments, threads, or the like
D01F 6/74 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polycondensates of cyclic compounds, e.g. polyimides, polybenzimidazoles
D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements
D06M 101/30 - Synthetic polymers consisting of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
H01G 11/24 - Electrodes characterised by the structural features of powders or particles used therefor
A microfluidic intercellular communication analysis device includes a coverslip and a Polydimethylsiloxane (PDMS) layer attached to the coverslip, the PDMS layer comprising a plurality of microfluidic channels each having an inlet and an outlet, the plurality of microfluidic channels comprising a donor cell channel structured to receive a donor cell population, a recipient cell channel structured to receive at least a recipient cell population and a matrix channel comprising a diffusion barrier having pores, the donor cell channel and the recipient cell channel each comprising inlets and outlets having an arc angle ranging from 180° to 300°, the arc angle structured to prevent cell aggregation in the inlets, the outlets and/or channel surfaces thereof, wherein upon injecting the donor cell population and the recipient cell population, the target subject is imaged by an imaging device and analyzed for intercellular communication and/or functional characterizations for ensuing intercellular communication effects.
Highly microporous laser fabricated three-dimensional graphene which can be prepared from a fluorinated polyimide is disclosed as a material suitable for a neural electrode, e.g., a neural stimulation device. The three-dimensional porous graphene incorporated into the device may have a multi-scale structure, which enables electrical and charge carrying properties. In some aspects, the porous graphene incorporated into the device has the following pore structure: macropores having an average pore size exceeding 50 nm; mesopores having an average pore size of 2-50 nm; micropores having an average pore size of 2 nm or less; and nanopores having an average pore size of less than 100 nm. Neural stimulation devices and methods of using the devices are also described.
A transistor includes a gate, a channel, a gate dielectric at least partially disposed between the gate and the channel, and at least one two-dimensional (2D) layer of a heterostructure disposed within the gate dielectric and spaced from both the gate and the channel. The channel and at least one 2D layer are configured to define a negative quantum capacitance such that a subthreshold slope of the transistor is less than 60 mV/dec.
H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , , or
Highly microporous laser fabricated three-dimensional graphene which can be prepared from a fluorinated polyimide is disclosed. The three-dimensional porous graphene may have a multi-scale structure, which enables optimum photodetection, particularly across the visible wavelengths, and other improved optical properties. In some aspects, the porous graphene has the following pore structure: macropores having an average pore size exceeding 50 nm; mesopores having an average pore size of 2-50 nm; micropores having an average pore size of 2 nm or less; and nanopores having an average pore size of less than 100 nm. A broadband, high-sensitivity photodetector based on three-dimensional (3D) porous graphene is also disclosed. The 3D porous graphene may be derived from a fluorinated polyimide, via for example a laser photothermal method. The porous graphene exhibits an ultrahigh specific surface area, facilitating optical-absorption properties, such as light-absorbing area and optical resonance.
Aspects of the present disclosure generally relate to systems and processes for automated skin feature detection and analysis, and more particularly to identifying and assessing the characteristics and age of skin contusions, bruises, and other similar skin features using a deep learning model. Images of a patient's body part are captured via a digital camera with a light source. The parameters of the light source are determined, and other information is gathered, including skin color and medical history of the patient/subject. Images of an injured area are combined with contextual clinical information as inputs to a machine learning model. The machine learning model detects and estimates characteristics of skin features. In an exemplary embodiment, the machine learning model detects bruises on the skin, and estimates their age and outputs the estimate to an end user along with a measurement of the uncertainty in the estimate.
Hyperspectral imaging (HSI) of biofluids for biometric applications is disclosed. A HSI device scans a region of a human subject's skin with sweat thereon, without requiring the human subject to touch any surface. The resulting HSI data is processed to identify aspects of the data that represent physical and/or chemical features that uniquely identify the subject. Processing the HSI data includes identifying one or more particular metabolites in the subject's sweat by analyzing wavelengths which those metabolites reflect. Processing the HSI data includes identifying one or more glands beneath the outermost surface of the subject's skin based on HSI-detected wavelength reflectance and wavelength penetration. The disclosed system may generate and store an identity profile corresponding to a human's unique identity features, as determined based on the HSI data processing. A subject's identity is verified by comparing subsequent HSI scans of his skin with sweat thereon to his stored identity profile.
The present disclosure generally relates to methods and systems for identifying shared information between different DNA sequences, that bind the same protein, based on alignment of major groove hydrogen bonding between the different sequences. Such methods may be useful for designing novel DNA binding proteins, as well as identification of novel DNA protein binding consensus sequences, for use in gene therapies, treatment of diseases or disorders resulting from aberrant gene expression and/or cell proliferation, as well as pathogenic infections.
An Embodiment relates to a method comprising: co-expressing a viral vector of a virus of interest and a CD34 expression vector into a human cell line to produce virus particles such that CD34 incorporates into the virus particles; isolating the virus particles from the human cell line; blocking a viral infection; and wherein the method is configured for inhibiting the viral infection of the virus of interest.
A method and system provide and utilize obfuscated fonts for displayable content. Responsive to a request for displayable content having text, a text portion of the requested displayable content to be obfuscated is determined. For that text portion, obfuscated fonts are provided, by retrieving obfuscated fonts or by generating obfuscated fonts from a set of obfuscated glyphs created from a plurality of glyphs representative of a plurality of characters of the text portion of the displayable content. The obfuscated fonts can be created by assigning obfuscated glyphs of the set into the obfuscated fonts in accordance with one or more messages. The obfuscated fonts are mapped by assigning a value to each obfuscated glyph in the set that is different from an original value of the glyph.
In an embodiment, present invention relates to a method of generating, ex vivo production of soluble Lox-1 (sLox-1), comprising: introducing a sample containing blood into a device; adding a coagulation enhancing material in the sample to form a cultured blood clot; incubating the cultured blood clot in the device at a temperature greater than 25° C. and less than 45° C. for at least 2 hours to allow production of Lox-1 from neutrophils of blood and to shed the sLox-1 outside the cultured blood clot; and collecting sLox-1 shedded in the device, wherein the method is configured to shed sLox-1 more than fresh blood.
The invention relates to a relates to a highly sensitive, non-invasive diagnostic method for detection infectious diseases. In one embodiment, the invention relates to novel rapid, self-working, visual field test for a panel of disease specific derived biomarkers. In one embodiment, the invention comprises a collecting device comprising a collapsible non hygroscopic net tethered with immobilized nanoparticles to capture and concentrate a target analyte present in a fluid; wherein the nanoparticle comprises a core and a shell, wherein the core comprises a molecular bait. The invention also relates to identification of biomarkers for identification of various pathogenic diseases.
The present disclosure relates to compositions, devices and methods for removing/filtering out microorganisms from a given fluid. The composition of the present invention comprises a non-water imbibing, biocompatible filament and at least one affinity ligand that is capable of capturing the microorganism(s). The invention also discloses methods for detection, diagnosis, and/or treatment.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
C02F 1/28 - Treatment of water, waste water, or sewage by sorption
29.
Heteromultivalent Nucleic Acid Scaffolds and Uses Thereof
The present disclosure relates to heteromultivalent nucleic acid scaffolds and peptides, and to compositions comprising the scaffolds and peptides, and to methods for preparing and using the scaffolds and peptides. The present disclosure also relates to use of the scaffolds, peptides, and compositions for preventing or disrupting interactions between molecules, in particular protein-protein interactions, in particular for the treatment or prevention of disease, in particular cancer, such as breast cancer.
14 - Precious metals and their alloys; jewelry; time-keeping instruments
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
41 - Education, entertainment, sporting and cultural services
Goods & Services
clothing, namely men's, women's and children's shirts, T-shirts, sweatshirts, pants, hats, and clothing jackets sporting articles, namely, basketballs, baseballs and golf balls, playing cards watches, jewelry, namely, rings, clocks, necklaces, earrings, and jewelry charms decals, looseleaf binders, paper coasters, pens, pencils, paper napkins, writing paper, book covers, paper notebooks, writing tablets, file folders featuring binders, examination books, postcards, wrapping paper, printed school yearbooks, printed calendars, and printed student directories bags, namely, tote bags, backpacks, duffel bags, and briefcases drinking glasses, coffee mugs/cups, drinking glasses, namely, tumblers, plates, thermal insulated sleeves for drinking containers, bottle openers, pitchers, salt and pepper shakers, and waste baskets providing courses of instruction at the university level and distribution of course material in connection therewith; entertainment services in the nature of collegiate sporting events and competitions
31.
Federated Graph Neural Network for Fast Anomaly Detection in Controller Area Networks
A method and apparatus for intrusion detection includes generating graph data from a sequence of messages in a communication network. The graph data denotes a node for each message identifier in the sequence of messages and an edge for each pair of consecutive message identifiers. Pair counts are generated for edges in the graph data as a number of times the associated pair of consecutive message identifiers occurs in the sequence. Input feature vectors are generated for nodes in the graph data. The vectors include data content of messages associated with the node and a pair count for each edge connected to the node. The input feature vectors are processed through a first graph neural network, based on the graph data, and then through one or more layers of a classifier to classify the sequence of messages as containing an anomaly or not.
H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
32.
SYSTEMS AND METHODS FOR KNOWLEDGE DISCOVERY FROM DATA AND PRIOR KNOWLEDGE
A system for knowledge discovery includes a processor and a memory. The memory includes instructions which, when executed by the processor, cause the system to: access a reference case of a plurality of cases; generate argumentation explaining a phenomenon of the reference case by developing a predictive model; generate a knowledge-based generalization of the argumentation; apply the argumentation to a plurality of cases similar to the reference case based on knowledge-based search and classification; split the plurality of similar cases into a plurality of favoring cases and a plurality of disfavoring cases; select a disfavoring case based on a similarity of factors; determine what factors were not taken into account in generating the argumentation; and generate a hypothesis-driven explanation theory based on comparing one or more features of the reference case to one or more features of the most disfavoring case.
In accordance with one aspect, a system for facilitating carbon-equivalent offsets from contrails includes at least one processor and at least one memory storing instructions. The instructions, when executed by the at least one processor, cause the system at least to: identify a flight designated for a contrail reduction procedure; determine, after the flight is completed, whether the flight executed the contrail reduction procedure and achieved contrail reduction; and based on determining that the flight executed the contrail reduction procedure and achieved contrail reduction, include, in a carbon offset exchange service, a carbon-equivalent offset listing corresponding to the flight.
An embodiment of the invention provides a method of generating, ex vivo production of soluble Lox-1 (sLox-1), comprising: introducing a sample containing a blood free from an anti-coagulant factor into a device; adding a coagulation enhancing material in the sample; incubating the device; forming a cultured blood clot in the device; and shedding of the sLox-1 outside the cultured blood clot, wherein the method is configured to shed sLox-1 more than an anti-coagulated blood.
Described are implantable devices comprising DNA nanostructures comprising a cell ligand at a proximal end tethered to an implantable substrate at a distal end for delivery of CpG oligodeoxynucleotides to cancer cells and methods of use and systems thereof.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C12N 15/117 - Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
36.
SYSTEMS AND METHODS FOR FACILITATING NAVIGATION IN SPACE
A navigation system for facilitating navigation in a space includes a network interface configured to access a representation of a space, a memory storing instructions, and at least one processor coupled with the memory. The at least one processor executes the instructions to detect objects in the representation of the space and determine a plurality of desirable positions which facilitate navigation in the representation of the space based on the detected objects.
An embodiment of the invention provides a composition comprising a carbon material and an ionic liquid (IL), wherein the composition is configured to form a reactive oxygen species (ROS) in presence of oxygen and a radiation having wavelength in a range of about 150 nm to about 1100 nm. In another embodiment, the invention provides a method to generate ROS using the ionic liquid (IL) and the carbon material and the method to measure the same in situ.
A method of authenticating a user that includes initializing the multi-factor authentication system based on an input; presenting a challenge requesting the user to enter a specific authenticator of a sequence of authenticators stored in the multi-factor authentication system, where the stored sequence of authenticators represents a combination of a plurality of authentication factors; receiving an authenticator from the user in response to the challenge; verifying identity of the user by determining whether the received authenticator matches the specific authenticator requested by the challenge; and granting the access based on a determination that the received authenticator matches the specific authenticator requested, or denying the access based on a determination that the received authenticator does not match the specific authenticator requested.
Systems and methods for countering the usage of autonomous or semi-autonomous vehicles for ramming attacks on a roadway are disclosed. Digital representations of physical trajectories (e.g., roadway travel routes) across which vehicles are expected or permitted to travel are generated based at least on travel-related data (e.g., sensor readings) received from the vehicles over wireless networks. The disclosed systems and methods further generate digital representations of physical trajectories across which vehicles are not permitted to travel, such that the impermissible physical trajectories constitute a deviation from a safe travel route. Additional travel-related data is continuously received from the vehicles in real-time, and the additional data may be combined with non-vehicle data (e.g., pedestrian travel data) and compared to the generated digital representations of permissible and impermissible physical trajectories to determine if the vehicles' physical trajectory is indicative of a harmful impermissible physical trajectory, such as a vehicular ramming attack.
The present invention relates to a composition comprising a growth medium comprising a carbon source, a nitrogen source, a sulphur containing amino acid and Ferric pyrophosphate; wherein the growth medium has no blood; wherein the growth medium is configured to allow growth of a living microorganism. Further, the invention also relates to method to prepare the composition.
Provided is a modified J-aggregate (MJ). In some embodiments, the MJ is nanoscale, sub-micronscale, or microscale. Also provided is an MJ conjugate. Also provided are processes for making an MJ or an MJ conjugate. Photoacoustic imaging methods employing the MJ or MJ conjugate are also provided.
C09B 23/04 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups one CH group, e.g. cyanines, isocyanines, pseudocyanines
42.
DEVICE AND ANALYSIS METHOD FOR APPRECIATING AND IDENTIFYING SMELLS
According to an embodiment, it is a system, comprising, a specialized device comprising, a flow sub-system configured for sampling a gas sample, a gas chamber having a gas sensor array comprising a configurable sensor interface, wherein the specialized device is operable to collect an aroma signal from the gas sample, a microcontroller comprising a processor and a memory operable to digitalize the aroma signal to obtain aroma data, store and transfer an aroma data, perform an aroma analysis on the aroma data, and provide a feedback to a user, wherein the system is an aroma evaluation system operable to detect a target aroma in real-time, and wherein the system is operable to interface to at least one of a cloud platform and a smartphone.
The present disclosure describes methods for determining the functional consequences of mutations. The methods include the use of machine learning to identify and quantify features of all atom molecular dynamics simulations to obtain the disruptive severity of genetic variants on molecular function.
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G16B 10/00 - ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
Detection of behavior anomalies in control systems and related systems, methods, and devices is disclosed. A method of detecting behavior anomalies in a control system includes probing emanations from a processor controlling at least a portion of the control system to provide an emanations signal, amplifying the emanations signal to provide an amplified emanations signal, and sampling the amplified emanations signal using a sampling rate that is greater than a clock frequency of a processor clock of the processor to provide samples. The method also includes determining whether or not the processor is exhibiting a behavior anomaly responsive to the samples.
G05B 19/406 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by monitoring or safety
Provided is an engineered antimicrobial peptide. Also provided is a composition comprising an engineered antimicrobial peptide. Provided is a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of a composition comprising an engineered antimicrobial peptide. Also provided is a method of producing an engineered antimicrobial peptide.
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
An embodiment relates to a reagent buffer comprising a zwitterionic sulfonic solution, a non-ionic surfactant solution, and a buffer solution, wherein the reagent buffer has a pH range of about 7.0 to about 8.0 and a circular dichroism with an absorbance peak more than 0 at 190 nm and 225 nm. In an embodiment, the reagent buffer is configured to be a reagent buffer for a lateral flow immunoassay for detection of COVID-19.
A wireless multi-edge computing (MEC)-based road-side unit (RSU) (RSU-MEC) system and method for traffic management. The traffic management system includes: a first fifth-generation cellular (5G) roadside unit (RSU), the first RSU operable to couple to a first mobile user element (UE) via a first wireless link; a second 5G RSU, the second RSU operable to couple to a second mobile UE via a second wireless link; a first multi-access edge computing (MEC) host of the first 5G RSU, operable to provide one or more of compute resources, storage resources, and network resources by executing at least a first application to manage vehicle traffic flow in a first cellular zone; and a second MEC host of the second RSU, operable to provide one or more of compute resources, storage resources, and network resources by executing at least a second application to manage vehicle traffic flow in a second cellular zone, the second application being coupled to the first application via an application programming interface (API) in a manner that facilitates management of vehicle traffic flow in a combined cellular zone by the first application and the second application.
A computer-implemented method of detecting one or more objects in a driving environment located externally to a vehicle, and a vehicle imaging system configured to detect one or more objects. The computer-implemented method includes training a first neural network to detect objects in a color video stream, the first neural network having a plurality of mid-level color features at a plurality of scales, and training a second neural network, operatively coupled to color neural network and an infrared video stream, to match, at the plurality of scales, mid-level infrared features of the second neural network to mid-level color features of the first neural network. A pixel-level invisibility map is then generated from the color video stream and the infrared video stream by determining differences, at each of the plurality of scales, between mid-level color features at the first neural network and mid-level infrared features at the second infrared neural network, and coupling the result to a fusing function.
G06N 3/04 - Architecture, e.g. interconnection topology
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestrians; Recognition of traffic objects, e.g. traffic signs, traffic lights or roads
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
49.
DNA NANOSTRUCTURES FOR BOOSTING IMMUNITY AGAINST CANCER
Described are implantable devices comprising DNA nanostructures comprising a cell ligand at a proximal end tethered to an implantable substrate at a distal end for delivery of CpG oligodeoxynucleotides to cancer cells and methods of use and systems thereof.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Tacrolimus is an immunosuppressant drug. The present disclosure provides an anti-fibrotic agent by transforming Tacrolimus, such that the anti-fibrotic agent is used for treating fibrosis. The anti-fibrotic agent is not immunosuppressant. In one embodiment, the present invention provides a method to transform Tacrolimus into an anti-fibrotic agent.
C07D 225/00 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
A61P 11/00 - Drugs for disorders of the respiratory system
51.
ANTIMICROBIAL PEPTIDES AND COMPOSITIONS, METHODS, ARTICLES & KITS RELATING THERETO
Peptides are described herein, in particular peptides having antimicrobial properties, as are compositions, articles, and kits comprising such peptides, and methods for using the peptides.
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
George Mason University (USA)
Inventor
Curiel, Clara N.
Baker, Amanda Fern
Dickinson, Sally E.
Petricoin, Iii, Emanuel F.
Abstract
The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-Li signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway suppressing therapy to prevent skin cancer development.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
Technologies are provided for generation of exertion-aware paths. Some embodiments include a computing system that can generate a path based at least on first data defining a terrain, second data defining a target level of total work, and third data defining a target level of perceived difficulty. The computing system also can generate a road surface along the path. Generating the road includes embedding metadata defining position-dependent resistance forces based on a physics model, the metadata controlling force feedback at virtual-reality equipment. The computing system also can supply the road surface to the virtual-reality equipment.
A Human Machine Hybrid (HMH) pill shape classification system uses a decision tree with interpretable metrics. The disclosed approach for pill shape classification requires human intervention for determining the meta-classes and variables used. The creation of decision boundaries is accomplished with machine learning (ML) algorithms. Scatter plots are manually inspected to find candidate pairs of variables and potential meta-classes.
A plurality of road-to-traveler feedback (“RTF”) devices integrated with a plurality of electronic computing devices transmits location data to a server. The server transmits to the RTF devices traffic signal timing data based on the location data. RTF devices present suggested velocities based on the traffic signal timing data, such that if a traveler conformed to the suggested velocities and other travel-related data, the traveler would position himself into a geographic region on a roadway in which the traveler is ensured to avoid red lights and other traffic impediments. The server is operatively connected to traffic controllers and receives traffic light state data. The server facilitates a plurality of geographic regions based at least on the traffic light state data and detected travelers on roadways, wherein each of the geographic regions are synchronized to allow continuous traffic flow for the travelers positioned therein.
A dynamically deployable, low visibility pneumatic cofferdam for flood mitigation is disclosed. The cofferdam includes a first planar component, a second planar component, an inflatable hermetic airbag sandwiched therebetween, and connection members attached to the first planar component, a second planar component to form a cofferdam unit. The connection members are adjustable to apply and maintain a desired amount of pressure on the airbag to enable a watertight seal to be formed. The cofferdam units may be sized and designed to sealingly mate adjacent cofferdam units in a variety of configurations to form watertight seals. The cofferdam units may also be sized and designed to attach to seawalls, flood walls, sidewalks, or other infrastructure. When in a deployed state, the height of the cofferdam may be adjusted to a desired height to provide flood mitigation. When in an undeployed state, the cofferdam remains in a substantially flat and unobtrusive position.
A low-power (e.g., battery-operated, etc.) wearable ultrasound system may be used to monitor the musculoskeletal function of a subject and provide information that may be used for electrical stimulation.
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
Devices and systems are disclosed which reduce compressional forces and allows for the induction of mild CCI injuries. An exemplary device features a resettable fall-away platform which allows for ultra-mild injuries to be induced on mice that are under light anesthesia. The result is injuries which do not produce long periods of unconsciousness, do not cause compressive injury and cause no increase in time-to-righting over control mice.
Automatic Dependent Surveillance Broadcast (ADS-B) is one of the most prominent air traffic surveillance technologies. It can be used not only as a complement in existing radar-based technologies to locate aircraft, but also as a replacement in areas without radar coverage. However, a major flaw in the deployment of this technology is it reliance on clear-text, open broadcast of messages, which makes it vulnerable to attackers. A solution to this vulnerability is ADS-Bsec, a holistic framework that solves the root cause of ADS-B problems by enforcing authenticity and integrity in ADS-B messages. This is accomplished without changing the message format and, along with a proper key exchange mechanism. The framework also leverages results from radio-location add risk-adaptive techniques in order to prevent attacks targeting ADS-B. ADS-Bsec is a promising framework for integrating ADS-B to NextGen infrastructure in a secure and affordable fashion.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
G01S 19/03 - Cooperating elements; Interaction or communication between different cooperating elements or between cooperating elements and receivers
The invention relates to a relates to a highly sensitive, non-invasive diagnostic method for detection infectious diseases. In one embodiment, the invention relates to novel rapid, self-working, visual field test for a panel of disease specific derived biomarkers. In one embodiment, the invention comprises a collecting device comprising a collapsible non hygroscopic net tethered with immobilized nanoparticles to capture and concentrate a target analyte present in a fluid; wherein the nanoparticle comprises a core and a shell, wherein the core comprises a molecular bait. The invention also relates to identification of biomarkers for identification of various pathogenic diseases.
Cells and lipid-based structures are described herein, in particular cells and lipid-based structures comprising membrane portions derived from cells having a label covalently attached thereto, as are compositions and kits comprising such cells and structures, and methods for using the cells and structures, in particular for determining membrane coverage and/or orientation as well as for screening methods/assays, and the like.
C12N 5/078 - Cells from blood or from the immune system
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C07D 271/12 - Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Molecularly imprinted particles comprising a label are described herein, in particular such particles prepared by RAFT polymerization, as are compositions and kits comprising such particles, and methods for preparing and using such particles.
Embodiments relate to a method comprising (a) expressing a vector comprising a PSGL-1 (P-selectin glycoprotein ligand-1) or a mutant thereof in a VPC (virus producing cell); and blocking a virus infection by inactivating an infectivity of a released virions from the VPC; or (b) expressing a glycoprotein or a mutant thereof in the VPC; blocking the virus infection by preventing binding of the released virions to a target cell; inactivating infectivity of the released virions; and targeting a viral infection. Other embodiments relate to (1) a broad-spectrum anti-viral product comprising: a vector expressing a glycoprotein or a mutant thereof in a VPC; and blocking a virus infection by inactivating infectivity of a released virion from the VPC; and (2) a vaccine comprising a viral particle is configured to a live attenuated or an inactivated or a non-infectious, wherein the viral particle are produced in a VPC.
Methods and system for improved aircraft safety are described herein. A machine learning model may be trained using historical flight data for a number of previously flown flights where an automation function autonomously disengaged. The trained machine learning model may be used to generate probabilistic alert rules. The probabilistic alert rules may be used by a computing device onboard an aircraft to provide contextual information to flight crew relating to engagement status for one or more automation functions of the aircraft.
Embodiments relate to methods comprising expressing or overexpressing P-selectin glycoprotein ligand-1 (PSGL-1) in human immunodeficiency virus (HIV) producing cells; isolating HIV particles from the HIV producing cells; and preparing the isolated HIV particles as a HIV vaccine. Embodiments relate to systems comprising a HIV vaccine comprising live attenuated, inactivated, or non-infectious HIV particles. Embodiments relate to systems capable of performing a method comprising administering a vaccine comprising live attenuated, inactivated, or non-infectious HIV particles to a subject in need of the vaccine; and treating or preventing one or more disease states in the subject resulting from HIV infection. Embodiments relate to methods comprising expressing or overexpressing PSGL-1 in virus producing cells; and inhibiting viral infection; or inhibiting viral spreading; or inactivating viruses and virus producing cells; or producing non-infectious virion particles; or allowing the virus producing cells to produce non-infectious virions, isolating the virions, and preparing non-infectious virions, the virions being HIV particles.
The present invention provides modified alphaviruses and compositions, methods, and kits for preparing and using them to elicit an immune response to an alphavirus in a subject.
42 - Scientific, technological and industrial services, research and design
Goods & Services
providing temporary use of online non-downloadable software for use in the testing and diagnosis of COVID-19, coronavirus, and other diseases; providing temporary use of online non-downloadable software for monitoring individual body temperature and to manage alarms and access in areas with flows of people in transit such as hospitals, supermarkets, railway stations, schools, airports, companies, offices, shopping centers
Devices for generating electrical energy along with methods of fabrication and methods of use are disclosed. An example device can comprise one or more layers of a transition metal dichalcogenide material. An example device can comprise a mechano-electric generator. Another example device can comprise a thermoelectric generator.
H10N 10/852 - Thermoelectric active materials comprising inorganic compositions comprising tellurium, selenium or sulfur
H10N 10/00 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
GEORGE MASON UNIVERSITY (USA)
Inventor
Curiel, Clara N.
Baker, Amanda Fern
Dickinson, Sally E.
Petricoin Iii, Emanuel F.
Abstract
The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-L1 signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway supressing therapy to prevent skin cancer development.
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
71.
Antimicrobial peptides and compositions, methods, articles and kits relating thereto
Peptides are described herein, in particular peptides having antimicrobial properties, as are compositions, articles, and kits comprising such peptides, and methods for using the peptides.
Methods of detecting and treating cognitive impairment are provided. The methods involve determining, via a metagenomic analysis, the salivary and/or gut microbiota signature of the subject, e.g. a subject with an illness such as chronic liver disease and/or post-traumatic stress disorder (PTSD), and based in the microbiota signature, identifying subjects who have cognitive impairment.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
73.
Alkenyl and beta-substituted phosphonates as antimicrobial agents
The George Washington University, A Congressionally Chartered Not-for-Profit Corporation (USA)
Washington University (USA)
George Mason University (USA)
St. Louis University (USA)
Inventor
Dowd, Cynthia
Wang, Xu
Brothers, Robert Carl
John, Audrey Ragan Odom
Edwards, Rachel
Meyers, Marvin
Arnett, Stacy
Couch, Robin
Heidel, Kenneth
Abstract
Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.
A system for autonomous control in power systems is disclosed. In particular, a secure overlay communication model (“SOCOM”) is disclosed, the system including a combination of hardware and software for detecting power grid states, and determining appropriate actions for addressing detected states. The SOCOM is a logic-based system deployed onto computing devices such as field programmable gate arrays installed at bus controllers, Supervisory Control and Data Acquisition Systems (“SCADAs”), Intelligent Electronic Devices (“IEDs”), or other computing devices in power grid stations and substations. The logic-based nature of the SOCOM allows for seamless integration with preexisting power system equipment. In response to detecting various power grid faults such as line failures and over-current states, the system automatically rearranges power line configurations at the power stations and/or substations. The SOCOM further provides improvements relating to optimal power flow, cost-based power distribution, load management, voltage/volt-amp reactance (“VAR”) optimization, and self-healing.
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the network; Circuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
Disclosed are methods and systems for system call reduction. An application container may be used to encapsulate an application and to determine an operation state of the application. Based on the application state, the application container may determine one or more allowable system calls for the application. The application container may restrict access to one or more system calls excluded from the one or more allowable system calls.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
An embodiment relates to a method, comprising: obtaining a biological sample, performing a protein complex immunoprecipitation (Co-IP) on the sample, performing a reverse phase protein array (RPPA) on the sample after performing the protein complex immunoprecipitation, and identifying one or more protein complexes. A further embodiment relates to a method of treatment, comprising: obtaining a tissue sample from a patient, performing Co-IP then RPPA on the sample, identifying a protein complex, determining whether the protein complex comprises known protein drug targets, and treating the patient with a drug that interacts with the known protein drug targets.
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
Embodiments relate to expressing or overexpressing P-selectin glycoprotein ligand-1 (PSGL-1) in human immunodeficiency virus (HIV) producing cells; isolating HIV particles from the HIV producing cells; and preparing the isolated HIV particles as a HIV vaccine. Embodiments relate to a HIV vaccine comprising live attenuated, inactivated, or non-infectious HIV particles. Embodiments relate to systems performing a method comprising administering a vaccine comprising live attenuated, inactivated, or non-infectious HIV particles to a subject in need of the vaccine; and treating or preventing one or more disease states in the subject resulting from HIV infection. Embodiments relate to expressing or overexpressing PSGL-1 in virus producing cells; and inhibiting viral infection; or inhibiting viral spreading; or inactivating viruses and virus producing cells; or producing non-infectious virion particles; or allowing the virus producing cells to produce non-infectious virions, isolating the virions, and preparing non-infectious virions, the virions being HIV particles.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing seminars, workshops, discussions, lectures, conferences, and debates in the fields of politics, public policy, civil discourse, civil society, speech, communications, and law
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing training, classes, workshops, and in person forums for conferences and user-generated unconferences in the fields of the digital humanities
80.
Bacterial profile to detect fungal taxa abundance in the gut
Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The present disclosure describes methods for determining the functional consequences of mutations. The methods include the use of machine learning to identify and quantify features of all atom molecular dynamics simulations to obtain the disruptive severity of genetic variants on molecular function.
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G16B 10/00 - ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
The present disclosure provides a method of restoring immune reconstitution, immune control of viremia, and one or more T cell functions in a subject infected with HIV. The method includes administering to the subject infected with HIV an agent that targets the cofilin pathway.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A secure hardware-based module or Security Electronic Control Unit (SECU) for a Controller Area Network (CAN) prevents an attacker from sending malicious messages through the CAN bus to take over control of a vehicle. The SECU shares a unique key and counter with each ECU on the CAN bus. When a legitimate ECU sends a message, it first compresses the message and then generates a MAC of the counter and a secret key. The counter is increased by one for each transmitted message. The ECU then fits the compressed message and the MAC into one CAN frame and sends it onto the CAN bus. The SECU performs the message verification on behalf of the intended receiver(s) of the message. If the verification passes, the receiver(s) simply decompress the message and use it as a normal CAN message. If the verification fails, the SECU will corrupt the CAN frame before it is fully received by the intended receiver(s). The corrupted CAN frame will be ignored by the intended receiver(s) as if it was never received. Therefore, a malicious message generated by an attacker will inflict no damage on the system.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
H04L 9/06 - Arrangements for secret or secure communications; Network security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
H04L 9/12 - Transmitting and receiving encryption devices synchronised or initially set up in a particular manner
H04W 4/48 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for in-vehicle communication
Methods of treating or preventing cancer, diabetes, and/or obesity in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of an SLC25A1 inhibitor as described herein. Also provided herein are pharmaceutical compositions comprising an SLC25A1 inhibitor and a chemotherapeutic agent. Further provided herein are methods of inhibiting SLC25A1 in a cell.
C07C 311/29 - Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (USA)
GEORGE MASON UNIVERSITY (USA)
THE GEORGE WASHINGTON UNIVERSITY (USA)
Inventor
Motayed, Abhishek
Aluri, Geetha
Davydov, Albert V.
Rao, Mulpuri V.
Oleshko, Vladimir P.
Bajpai, Ritu
Zaghloul, Mona E.
Abstract
A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
86.
NOVEL ALKENYL AND BETA-SUBSTITUTED PHOSPHONATES AS ANTIMICROBIAL AGENTS
A device and system for conducting accurate diagnosis of states of disease or health, including cancer, with high sensitivity and specificity is described. The system employs a portable cassette-based testing system which is configured to detect analytes captured by hydrogel particles equipped with affinity bait(s) and an amplification reporter system. The affinity baits bind to a wide range of analytes, including: metabolites, proteins, nucleic acids, lipids, hormones, cytokines, growth factors, biomarkers, virus particles, exosomes, bacteria, fungi, drug compounds, synthetic organic compounds, volatile odorants, toxicants, and pollutants. The affinity baits bind with extremely high affinity, preserving the captured analyte. This system can increase the sensitivity of detection of said analytes up to ten-thousand-fold.
C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Devices for generating electrical energy along with methods of fabrication and methods of use are disclosed. An example device can comprise one or more layers of a transition metal dichalcogenide material. An example device can comprise a mechano-electric generator. Another example device can comprise a thermoelectric generator.
H01L 35/16 - Selection of the material for the legs of the junction using inorganic compositions comprising tellurium or selenium or sulfur
H01L 41/18 - Selection of materials for piezo-electric or electrostrictive elements
H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
H01L 35/00 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 35/02 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof - Details
H01L 35/34 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
89.
Age invariant face recognition using convolutional neural networks and set distances
Time lapse, characteristic of aging, is a complex process that affects the reliability and security of biometric face recognition systems. Systems and methods use deep learning, in general, and convolutional neural networks (CNN), in particular, for automatic rather than hand-crafted feature extraction for robust face recognition across time lapse. A CNN architecture using the VGG-Face deep (neural network) learning produces highly discriminative and interoperable features that are robust to aging variations even across a mix of biometric datasets. The features extracted show high inter-class and low intra-class variability leading to low generalization errors on aging datasets using ensembles of subspace discriminant classifiers.
The artificial body part control system using ultrasonic imaging includes of an ultrasonic transducer coupled with an ultrasonic image analyzer which may be adapted to transmit a control signal to an artificial body part.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERICE (USA)
GEORGE MASON UNIVERSITY (USA)
THE GEORGE WASHINGTON UNIVERSITY (USA)
Inventor
Motayed, Abhishek
Aluri, Geetha
Davydov, Albert V.
Rao, Mulpuri V.
Oleshko, Vladimir P.
Bajpai, Ritu
Zaghloul, Mona E.
Abstract
A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
92.
Method for manufacturing an array of sensors on a single chip
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERICE (USA)
GEORGE MASON UNIVERSITY (USA)
THE GEORGE WASHINGTON UNIVERSITY (USA)
Inventor
Motayed, Abhishek
Aluri, Geetha
Davydov, Albert V.
Rao, Mulpuri V.
Oleshko, Vladimir P.
Bajpai, Ritu
Zaghloul, Mona E.
Abstract
A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
93.
Method and apparatus for low-power ultraportable ultrasound imaging
Methods, systems, and apparatuses are disclosed for ultrasound imaging comprising Time Delay Spectrometry. A frequency swept signal can be transmitted through a medium, such as human tissue. The signal can be a low-voltage signal (e.g., 0 volts to 5 volts peak-to-peak) transmitted for long duration (e.g., 20 milliseconds) at various frequencies. As the signal propagates through the medium it can be reflected and delayed. A delay associated with the signal the can cause a change in the associated frequencies. The signal can be filtered to retain only frequencies in an audio frequency range. The signal can be beamformed and processed to produce an image.
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G01N 29/26 - Arrangements for orientation or scanning
G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
G01N 29/42 - Detecting the response signal by frequency filtering
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
G01N 29/07 - Analysing solids by measuring propagation velocity or propagation time of acoustic waves
G01N 29/265 - Arrangements for orientation or scanning by moving the sensor relative to a stationary material
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
94.
BACTERIAL PROFILE TO DETECT FUNGAL TAXA ABUNDANCE IN THE GUT
Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
A61K 35/66 - Microorganisms or materials therefrom
Traditional approaches to predicting aircraft trajectories using kinematic models cannot work due to the complexity of the approach maneuver including flaps/slats, landing gear, ATC vectors, winds, and other traffic. The methods and systems disclosed can utilize Big Data Analytics (e.g., massive amounts of data of flights on each approach) to nowcast the approach stability given the state of the flight prior to the 1000′/500′ check points.
In one aspect, the invention relates to methods and compositions for determining migration of a virus particle to the nucleus of a cell. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
C12N 15/62 - DNA sequences coding for fusion proteins
C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-lRAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-lRAcP with the IL-1R1 and IL-1β receptor/cytokine complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
Provided are methods, systems, devices of a security-driven design method. The present methods and systems can enable integration of security requirements in the early stages of design along with other design constrains so that potential attacks during IC development, usage, and retirement would render ineffectual. Example methods and systems can comprise circuits and circuit design using vanishable logic through a novel hybrid design method. An example method or system can comprise vanishable logic based on hardware re-configuration and transformation by employing non-volatile memory cells.
G06F 21/87 - Secure or tamper-resistant housings by means of encapsulation, e.g. for integrated circuits
G06F 21/76 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information in application-specific integrated circuits [ASIC] or field-programmable devices, e.g. field-programmable gate arrays [FPGA] or programmable logic devices [PLD]
100.
Highly selective nanostructure sensors and methods of detecting target analytes
The United States of America, as represented by the Secretary of Commerce (USA)
George Mason University (USA)
The George Washington University (USA)
Inventor
Motayed, Abhishek
Aluri, Geetha
Davydov, Albert V.
Rao, Mulpuri V.
Oleshko, Vladimir P.
Bajpai, Ritu
Zaghloul, Mona E.
Thomson, Brian
Wen, Baomei
Xie, Ting
Liu, Guannan
Debnath, Ratan
Abstract
A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
