Abstract

Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06T 7/12 - Edge-based segmentation
• G06T 7/149 - SegmentationEdge detection involving deformable models, e.g. active contour models
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G06T 7/00 - Image analysis

Abstract

The invention provides methods and compositions for treating cancer by administering to a patient in need thereof a therapeutically effective amount of 6,8-bis-benzylthio-octanoic acid and an autophagy inhibitor.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

To provide a secondary battery enabling quick charging, and a method for suitable use of the secondary battery.　A secondary battery system 1 comprises a hydrogen source 10 including a hydrogen production device. A secondary battery 11 comprises: a positive electrode 12; a negative electrode 13 containing a hydrogen absorbing alloy; a separator 14; and a container 15 accommodating the positive electrode 12, the negative electrode 14, and the separator 13. The secondary battery system of the present invention further comprises a hydrogen flow path 21 that connects the secondary battery 11 to the hydrogen source 10 so as to introduce hydrogen to the secondary battery 11 and to discharge excess hydrogen therefrom. In the secondary battery system 1 of the present invention, discharging and quick charging can be repeated by the step of supplying hydrogen from the hydrogen source 10 to the negative electrode 13, the step of discharging to supply electricity to an external load, the step of charging to supply a given current from an external power supply 30 to the positive electrode 12 and the negative electrode 13, and the step of discharging hydrogen that is a by-product of the charging step to the hydrogen flow path 21.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• H01M 4/32 - Nickel oxide or hydroxide electrodes
• H01M 10/30 - Nickel accumulators
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells

Abstract

The present invention addresses the issue of providing a recombinant phage that is highly safe and has excellent practicality and usefulness. Provided are: a recombinant bacteriophage that has lost proliferative capacity and can only infect once, as a result of having a bacteriophage genome having part of a virion-constituting gene deleted therefrom stored in the head thereof; and a preparation method therefor. Also provided are: a recombinant bacteriophage that has lost proliferative capacity and can only infect once, as a result of having a plasmid having a packaging site and coding a target gene stored in the head thereof; and a preparation method therefor.

IPC Classes  ?

• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• A61P 31/04 - Antibacterial agents
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/33 - Genes encoding viral proteins

Abstract

The invention provides methods and compositions for treating cancer by administering to a patient in need thereof a therapeutically effective amount of 6,8-bis-benzylthio-octanoic acid and an autophagy inhibitor.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/365 - Lactones
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

A method for producing a separation membrane where a zeolite film is formed on an inorganic oxide porous supporting body, said method comprising: a surface layer formation step wherein a surface layer containing 90% by weight or more of silica is formed on at least one of the surface of the supporting body and the inside of the supporting body in the vicinity of the surface of the supporting body; a loading step wherein the surface and/or the inside of the surface layer is loaded with a seed crystal of zeolite and a component that contains a structure directing agent; and a steam treatment step wherein the member obtained in the loading step is subjected to a treatment in a heated steam atmosphere.

IPC Classes  ?

• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/02 - Inorganic material
• C01B 39/04 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof using at least one organic template directing agent, e.g. an ionic quaternary ammonium compound or an aminated compound

Abstract

[Problem] To provide an electromagnetic wave measurement probe capable of measuring a spatial distribution state of electromagnetic waves by means of differential measurement. [Solution] This electromagnetic wave measurement probe includes a first measuring portion having a probe configuration comprising an electro-optic crystal exhibiting an electro-optic effect, an optical fiber which is provided on a base side of the electro-optic crystal and which transmits optical signals, and a reflecting portion which is provided on a distal end side of the electro-optic crystal and which reflects the optical signals, and a second measuring portion having a probe configuration, wherein, in first and second directions perpendicular to the axial direction of the optical fiber, the size of the electro-optic crystal is set to be at most equal to half the wavelength of the electromagnetic wave being measured, thereby enabling the electromagnetic wave to be measured with high precision.

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• G01R 29/10 - Radiation diagrams of antennas

Abstract

A motor according to the present invention is provided with: a stator; a rotor; a cylindrical housing; and a neutralizer array that has a prescribed specific vibration frequency. The neutralizer array has at least one neutralizer group that includes a plurality of neutralizers arranged in the rotational axis direction. The motor generates vibration of a prescribed frequency in response to rotation of the rotor. A system from the vibration source of the motor to a connection part between the motor and a device has a transmission function which has properties of suppressing vibration of the connection part at the prescribed specific vibration frequency.

IPC Classes  ?

• H02K 5/24 - CasingsEnclosuresSupports specially adapted for suppression or reduction of noise or vibrations
• B62D 5/04 - Power-assisted or power-driven steering electrical, e.g. using an electric servo-motor connected to, or forming part of, the steering gear
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system

Abstract

0o00, f.

IPC Classes  ?

• G01F 17/00 - Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
• A01K 61/95 - Sorting, grading, counting or marking live aquatic animals, e.g. sex determination specially adapted for fish

Abstract

The purpose of the present invention is to utilize blood PD-1 concentration as a biomarker for predicting a therapeutic effect of an immune checkpoint inhibitor on cancer, for evaluating cancer progression, or for predicting cancer recurrence. The present invention pertains to an agent for arresting cancer progression, for suppressing cancer recurrence, and/or for cancer treatment, the agent being characterized by containing an immune checkpoint inhibitor as an active ingredient and by being administered to cancer patients having a blood PD-1 concentration level less than a predetermined cutoff value.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The motor according to the present disclosure is provided with a stator, a rotor, a cylindrical housing, and a neutralizer having a predetermined natural frequency. The neutralizer has: an outer cover directly or indirectly fixed to the housing; an inner mass housed in a space formed by the outer cover and the outside surface of the housing; and one elastic member extending from the outer cover toward the space and supporting the inner mass so that the inner mass can vibrate in a plane including the circumferential direction and radial direction of the housing. Vibration having a predetermined frequency occurs in the motor in accordance with the rotation of the rotor, and a system from a vibration source of the motor to a connection portion between the motor and a device has a transfer function having a characteristic for suppressing the vibration of the connection portion at a predetermined natural frequency.

IPC Classes  ?

• H02K 5/24 - CasingsEnclosuresSupports specially adapted for suppression or reduction of noise or vibrations
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system

Abstract

A method for reducing vibrations in an electric power steering device to which a typical motor is attached includes: a step for determining the frequency of vibrations to be reduced in the electric power steering device, which is the frequency of the vibrations produced by the motor; and a step for setting the properties of a neutralizer provided on the housing of the motor in a manner such that the transfer function of the system from the source of vibrations in the motor to the coupling part between the motor and the electric power steering device is provided with properties which suppress the vibrations in the coupling part at the determined vibration frequency.

IPC Classes  ?

• H02K 5/24 - CasingsEnclosuresSupports specially adapted for suppression or reduction of noise or vibrations
• B62D 5/04 - Power-assisted or power-driven steering electrical, e.g. using an electric servo-motor connected to, or forming part of, the steering gear
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system

Abstract

Provided are a hydrogen recycle system and a hydrogen recycle method, whereby hydrogen can be purified to high purity at high yield from a gas, said gas being exhausted from a nitride compound production device, and recycled. The hydrogen recycle system 1 comprises an exhaust gas supply path 11 supplying a gas exhausted from a nitride compound production device 2, a hydrogen recycle means 10 and a hydrogen supply path 12. The hydrogen recycle means 10 of the hydrogen recycle system 1 is characterized by comprising: a plasma reaction vessel 31 that defines at least a part of a discharge space 32; a hydrogen separation membrane 34 that divides the discharge space 32 from a hydrogen flow path 33 communicated with the hydrogen supply path 12, defines at least a part of the discharge space 32 by one surface thereof and also defines at least a part of the hydrogen flow path 33 by the other surface thereof; an electrode 35 that is disposed outside the discharge space 32; and an adsorbent 36 that is filled in the discharge space 32 and adsorbs the supplied exhaust gas.

IPC Classes  ?

• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C23C 16/44 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
• H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues

Abstract

This motor to be attached to a typical electric power steering device is equipped with a stator, a rotor capable of rotating relative to the stator, a housing which houses the stator and rotor therein and has a cylindrical shape which extends in the direction of the rotational axis of the rotor, and a neutralizer which is provided on the housing and extends in the radial direction of the housing from the lateral surface of the housing. Therein, vibrations of a prescribed frequency are produced in the motor according to the rotation of the rotor, the neutralizer has a prescribed unique vibration frequency, and the system from the source of vibrations in the motor to the coupling part between the motor and the electric power steering device has a transfer function provided with properties which suppress the vibrations in the coupling part at the prescribed unique vibration frequency.

IPC Classes  ?

• H02K 5/24 - CasingsEnclosuresSupports specially adapted for suppression or reduction of noise or vibrations
• B62D 5/04 - Power-assisted or power-driven steering electrical, e.g. using an electric servo-motor connected to, or forming part of, the steering gear
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system

Abstract

Provided is a hydrogen generating apparatus adaptable to fluctuating hydrogen demand, particularly by enabling large-scale hydrogen production, generating pure hydrogen at a high yield. The hydrogen generating apparatus 1 generates hydrogen gas from a source gas by decomposing the source gas through catalysis and transforming it into plasma through electric discharge. The hydrogen generating apparatus 1 includes a dielectric body 2 defining a source gas flow channel 13, a catalyst 10 that decomposes at least part of the source gas in the source gas flow channel 13 to generate hydrogen gas, an electrode 3 contacting the dielectric body 2, a hydrogen separation membrane 5 facing the electrode 3 across the dielectric body 2, a hydrogen flow channel 18 guiding hydrogen separated by the hydrogen separation membrane 5, and a high-voltage power supply 6 supplying power to cause electric discharge between the hydrogen separation membrane 5 and the electrode 3.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 3/58 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids including a catalytic reaction
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01J 21/04 - Alumina
• B01J 21/10 - MagnesiumOxides or hydroxides thereof
• H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means

Abstract

Provided are a hydrogen purification device and a hydrogen purification method whereby hydrogen having a high purity can be purified at a high yield from a starting gas. The hydrogen purification device 1 comprises: a starting gas source 9 that supplies a starting gas, said starting gas containing hydrogen molecules and/or a hydride, to a discharge space 3; a plasma reactor 2 that defines at least a part of the discharge space 3; a hydrogen flow channel 5 that is connected to the discharge space 3 and leads out purified hydrogen from the starting gas source 9; a hydrogen separation membrane 4 that partitions the discharge space 3 from the hydrogen flow channel 5, defines at least a part of the discharge space 3 by one surface thereof and defines at least a part of the hydrogen flow channel 5 by the other surface thereof; an electrode 7 that is positioned outside the discharge space 3; and an adsorbent 6 that is filled in the discharge space 3 and adsorbs the starting gas. In the hydrogen purification method according to the present invention, the starting gas is adsorbed by the adsorbent 6 in the discharge space 3. Hydrogen molecules, which have been desorbed from the adsorbent 6 by discharge, are allowed to penetrate through the hydrogen separation membrane 4 and led out into the hydrogen flow channel 5.

IPC Classes  ?

• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia

Abstract

Provided is a device such as a biosensor wherein a biomolecule and/or an organic compound is simply immobilized on a support so as to enable the occurrence of at least one phenomenon selected from among reaction, flow-out, flow-in and retention of the biomolecule and/or the organic compound. The device according to one embodiment comprises a porous support and a composite immobilized on the support, wherein: the composite comprises a microfibrous cellulose, said microfibrous cellulose having a number-average fiber diameter of 2-150 nm, having a cellulose I type crystalline structure and being anion-modified, and a biomolecule and/or an organic compound; one or more independent areas having the composite immobilized thereon are formed within the support; and, when water penetrates into the areas, at least one phenomenon selected from among reaction, flow-out, flow-in and retention of the biomolecule and/or the organic compound occurs.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C08L 1/02 - CelluloseModified cellulose
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12N 11/12 - Cellulose or derivatives thereof
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
• D06M 15/05 - Cellulose or derivatives thereof
• D06M 15/15 - Proteins or derivatives thereof
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• C12Q 1/46 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase involving cholinesterase

Abstract

A double-stranded nucleic acid molecule includes a first polynucleotide chain including a base sequence represented by Chemical Formula (1) (SEQ ID NO:1) and a second polynucleotide chain including a base sequence complementary to the first polynucleotide chain. A method for preventing and/or treating a tumor includes a step in which the double-stranded nucleic acid molecule is administered to a test subject.

IPC Classes  ?

• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/09 - Recombinant DNA-technology

Abstract

It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.

IPC Classes  ?

• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61K 35/51 - Umbilical cordUmbilical cord bloodUmbilical stem cells
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 35/54 - OvariesOvaOvulesEmbryosFoetal cellsGerm cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/35 - Fat tissueAdipocytesStromal cellsConnective tissues
• A61D 19/00 - Instruments or methods for reproduction or fertilisation
• A61D 19/02 - Instruments or methods for reproduction or fertilisation for artificial insemination
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• C12N 5/076 - Sperm cellsSpermatogonia
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

Provided is a hydrogen generating apparatus adaptable to fluctuating hydrogen demand, particularly by enabling large-scale hydrogen production, generating pure hydrogen at a high yield. The hydrogen generating apparatus 1 includes a tabular dielectric body 2 having a first surface 11 with a source gas flow channel 13 formed as a recess and a second surface 12 approximately parallel to the first surface 11, a grounding electrode 3, a hydrogen flow channel plate 4 with a hydrogen flow channel 18 and a hydrogen outlet 19, being arranged on a first surface 11 side of dielectric body 2, a hydrogen separation membrane 5 between source gas flow channel 13 and hydrogen flow channel 18, and a high-voltage power supply 6 that causes electric discharge in source gas flow channel 13 between hydrogen separation membrane 5 and grounding electrode 3. Hydrogen separation membrane 5 transmits hydrogen generated by electric discharge in source gas flow channel 13 into hydrogen flow channel 18.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• H01M 8/0606 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids

Abstract

Provided are: a nucleoside that is more suitable for practical use such as an RNA medicine or the like; and the use of the nucleoside. For this purpose, provided is a nucleoside derivative represented by formula (1) or (2) or a salt thereof. [Chem. 16] (In formula (1), R1represents a hydrogen atom, a hydroxy group, a hydroxy group in which a hydrogen atom is substituted with an alkyl group or an alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2and R3nnR5R6(n represents 0 or 1, R5and R6may be the same or different and each represent a hydrogen atom, a hydroxy group, a protected hydroxy group, a mercapto group, a protected mercapto group, a lower alkoxy group, a cyano lower alkoxy group, an amino group, or a substituted amino group. Note that when n is 1, R5and R6would not simultaneously be a hydrogen atom.), each R4represents NHR7having a linking group (R7 represents a hydrogen atom, an alkyl group, an alkenyl group, or a protecting group for amino group), an azide group, an amidino group, or a guanidino group, and B represents one of a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group, or a substituted 2-oxo-pyrimidin-1-yl group.)

IPC Classes  ?

• C07H 19/06 - Pyrimidine radicals
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07H 19/10 - Pyrimidine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 23/00 - Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided is an anomalous item determination method with which it is possible to determine an anomalous item accurately by performing machine learning using a large amount of normal data and a small quantity of anomalous data. Data relating to a plurality of items to be determined are input into an encoder-decoder structure network, features of the items to be determined are extracted, and a discriminator determines whether the distribution of the features of the items to be determined is in accordance with a normal distribution. Updating of the encoder-decoder structure network, updating of the discriminator, and updating of an encoder are each repeated to minimize a feature extraction error. The encoder, using a feature obtained by the updating, calculates an anomaly degree of the items to be determined, subjects the anomaly degree to threshold value processing, and determines whether the items to be determined are normal items or anomalous items. The step of determining whether the distribution of the features of the items to be determined is in accordance with a normal distribution comprises a step of inputting data in accordance with a normal distribution into the discriminator and calculating an error between the data and the features of the items to be determined extracted by the encoder-decoder structure network. Using the result of determination by the discriminator allows the features of the items to be determined that are used by the encoder for anomaly degree calculation to converge so as to be distributed in accordance with a normal distribution.

IPC Classes  ?

• G06N 3/08 - Learning methods

Abstract

Provided are: a method for producing an α-aluminum oxide particle, whereby a particle having a smaller particle size and high dispersibility can be produced with high purity; and an α-aluminum oxide particle produced by the production method. An α-aluminum oxide particle having a Feret diameter of at least 2 nm and less than 20 nm and a circularity of 0.82-0.86 is produced by a production method in which amorphous aluminum hydroxide, water, and carboxylic acid are mixed and stirred to prepare a precursor sol of α-aluminum oxide, and the undried precursor sol or a dried matter of the precursor sol is rapidly heated for 0.1-60 seconds from room temperature to a temperature range of 1000-1200°C, and the rapidly heated matter is rapidly cooled for 1 second to 10 minutes from the temperature range of 1000-1200°C to a temperature range of room temperature to 100°C.

IPC Classes  ?

• C01F 7/44 - Dehydration of aluminium oxide or hydroxide, i.e. all conversions of one form into another involving a loss of water
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Provided is a composite composition which is capable of stabilizing biomolecules. A composite composition according to one embodiment of the present invention contains biomolecules and anion-modified cellulose nanofibers that have a cellulose I type crystal structure; and this composite composition has a moisture content of 20% by mass or less. This composite composition is able to be obtained by mixing biomolecules and an aqueous dispersion of anion-modified cellulose nanofibers that have a cellulose I type crystal structure and subsequently drying the mixture until the moisture content thereof comes to 20% by mass or less. This composite composition is able to be used, for example, for a biosensor.

IPC Classes  ?

• C08L 1/02 - CelluloseModified cellulose
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C08J 3/21 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase the polymer being premixed with a liquid phase
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof
• C12N 11/12 - Cellulose or derivatives thereof

Abstract

Provided is a hydrogen generator which can flexibly respond to the change of supply quantity of hydrogen, and particularly, can easily respond to hydrogen mass production and can generate highly pure hydrogen in high yield. A hydrogen generator 1 generates hydrogen gas from raw material gas in high yield through decomposition by a catalyst and plasma gasification of the raw material gas by electric discharge. The hydrogen generator 1 comprises: a dielectric 2 that defines a raw material gas flow path 13; a catalyst 10 that generates hydrogen gas by decomposing at least part of raw material gas flowing through the raw material gas flow path 13; an electrode 3 that is disposed so as to be in contact with the dielectric 2; a hydrogen separation membrane 5 that faces the electrode 3 via the dielectric 2; a hydrogen flow path 18 through which hydrogen separated by the hydrogen separation membrane 5 is delivered; and a high voltage power source 6 that supplies electric power so as to generate electric discharge between the hydrogen separation membrane 5 and the electrode 3.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01J 35/02 - Solids
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means

Abstract

[Problem] To provide a hydrogen generator capable of easily controlling the amount of hydrogen generated, and capable of generating high-purity hydrogen with a high yield. [Solution] A hydrogen generator 1 comprises a dielectric 2, an electrode 3, a hydrogen separation membrane 5, and a high voltage power supply 6. The dielectric 2 is of a flat plate configuration that has a first surface 11 in which a raw material gas flow path 13 is formed as a continuous groove, and a second surface 12 that is substantially parallel to the first surface 11. The electrode 3 is disposed facing the second surface 12 of the dielectric 2, and the hydrogen separation membrane 5 is disposed on the first surface 11 side of the dielectric 2. The hydrogen separation membrane 5 covers the opening of the raw material gas flow path 13. The high voltage power supply 6 supplies power to the electrode 3 or the hydrogen separation membrane 5 and generates electric discharge. The electrode 3 and the hydrogen separation membrane 5 are disposed in asymmetric positions relative to the dielectric 2.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means

Abstract

Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06T 7/12 - Edge-based segmentation
• G06T 7/149 - SegmentationEdge detection involving deformable models, e.g. active contour models
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G06T 7/00 - Image analysis

Abstract

[Problem] To provide a strain not pathogenic to plants which exhibits a stable bacterial plant disease control effect at real crop production sites and which can be safely used as a biological pesticide, and to provide a bacterial plant disease control agent using said strain. [Solution] By using, as an active component, live bacteria, or a culture containing said live bacteria, of a bacterial strain of the genus Mitsuaria, which is not conventionally know to have a bacterial plant disease control effect, it is possible to provide a bacterial plant disease control agent such as a vegetable wilt disease control agent or a surface rot control agent.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A01C 1/00 - Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
• A01G 7/00 - Botany in general
• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A01P 3/00 - Fungicides
• A01P 21/00 - Plant growth regulators

Abstract

[Problem] To provide a new strain not pathogenic to plants which exhibits a stable bacterial plant disease control effect at real crop production sites and which can be safely used as a biological pesticide, and to provide a bacterial plant disease control agent using said strain. [Solution] By using, as an active component, live bacteria, or a culture containing said live bacteria, of the Ralstonia pickettii TCR 112 strain (NITE BP-02446), it is possible to provide a bacterial plant disease control agent such as a vegetable wilt disease control agent or a surface rot control agent.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A01N 63/02 - Substances produced by, or obtained from, microorganisms or animals
• A01P 3/00 - Fungicides
• A01P 21/00 - Plant growth regulators

Abstract

[Problem] To provide a bacterial plant disease control agent which has a stable plant disease control effect at real crop production sites and which can be safely used as a biological pesticide. [Solution] By using in combination, as active components, live bacteria, or a culture containing said live bacteria, of a strain belonging to the genus Mitsuaria having a bacterial plant disease control effect and a strain belonging to the genus Ralstonia not pathogenic to plants and having a bacterial plant disease control effect, it is possible to provide a bacterial plant disease control agent such as a vegetable wilt disease control agent or a surface rot control agent.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A01G 7/00 - Botany in general
• A01P 3/00 - Fungicides
• A01P 21/00 - Plant growth regulators
• C12N 1/20 - BacteriaCulture media therefor

Abstract

Provided are an outer cylinder for a hydraulic shock absorber having excellent productivity, and a method for molding the outer cylinder for a hydraulic shock absorber. The outer cylinder for a hydraulic shock absorber is provided with an intermediate body (20) and an outer case main body (10A). The intermediate body (20) has continuous reinforcing fibers knitted (textile-processed) in a tubular form. The outer case main body (10A) is molded from a polyamide resin that is a thermoplastic resin that forms irregularities on the outside of the intermediate body (20) while impregnating the intermediate body (20). Textile processing is a process for assembling, weaving, or knitting fibers to produce a flat or tubular fabric, cord, etc.

IPC Classes  ?

• B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
• B29C 45/26 - Moulds
• B29C 70/24 - Fibrous reinforcements only characterised by the structure of fibrous reinforcements using fibres of substantial or continuous length oriented in at least three directions forming a three dimensional structure
• F16F 9/32 - Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium Details

Abstract

A hydrogen generator is provided which can flexibly respond to changes in the amount of hydrogen supplied, and which in particular can easily handle mass production of hydrogen and can moreover generate high purity hydrogen with a high yield. This hydrogen generator 1 is provided with: a plate-shape dielectric 2 having a first surface 11 comprising a raw material gas flow path 13 formed as a recess and a second surface 12 approximately parallel to the first surface 11; a ground electrode 3; a hydrogen flow path plate 4 having a hydrogen flow path 18 and a hydrogen outlet 19 and arranged on the first surface 11 side of the dielectric 2; a hydrogen separation membrane 5 which is arranged between the raw material gas flow path 13 of the dielectric 2 and the hydrogen flow path 18 of the hydrogen flow path plate 4 and which partitions the raw material gas flow path 13 and the hydrogen flow path 18; and a high voltage power supply 6 which generates electric discharge inside of the raw material gas flow path 13 between the hydrogen separation membrane 5 and the ground electrode 3. Hydrogen generated from the raw material gas by electric discharge in the raw material gas flow path 13 is passed by the hydrogen separation membrane 5 into the hydrogen flow path 18 of the hydrogen flow path plate 4.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues
• H01M 8/0606 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants

Abstract

A compact fuel battery system is provided that has an integrated hydrogen generator. This fuel battery system 1 is provided with a hydrogen generator 10 and a fuel battery cell 20. The hydrogen generator 10 is provided with a plate-shape dielectric 2 having a raw material gas flow path surface 11 in which a raw material gas flow path 13 is formed. An electrode 3 faces the back surface 12 of the dielectric 2. A hydrogen separation membrane 5, which has a first surface 18 and the second surface 19, closes an opening of the raw material gas flow path 13. Furthermore, the hydrogen generator 10 is provided with a high-voltage power supply 6 which generates electric discharge between the hydrogen separation membrane 5 and the electrode 3. The fuel battery system is characterized in that the second surface 19 of the hydrogen separation membrane 5 of the hydrogen generator is arranged facing the fuel electrode 21 of the fuel battery cell 20.

IPC Classes  ?

• H01M 8/0606 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• H01M 8/10 - Fuel cells with solid electrolytes

Abstract

An MFI type zeolite membrane to be formed on a porous inorganic oxide substrate, wherein, in an X-ray diffraction pattern obtained by X-ray diffractometry measurement using CuKα ray as an X-ray source, the intensity of a diffraction peak assignable to crystal lattice plane of the 200 and/or 020 planes, said peak appearing at a diffraction angle of 8.4-9.0°, is 0.3 or greater, using the intensity of a diffraction peak assignable to crystal lattice plane of the 011 and/or 101 planes, said peak appearing at a diffraction angle of 7.3-8.4°, as a reference.

IPC Classes  ?

• C01B 39/38 - Type ZSM-5
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/02 - Inorganic material

Abstract

A method for producing a separation membrane in which: a zeolite film is formed on an inorganic oxide porous substrate; and the main component of a zeolite formation part of the substrate is amorphous SiO2. This method for producing a separation membrane comprises: a first step wherein a seed crystal of zeolite and an alkali component containing a structure-directing agent are formed on the surface of the substrate; and a second step wherein a formed body obtained in the first step is processed in a heated water vapor atmosphere. Consequently, a zeolite film is formed on the substrate surface in this method for producing a separation membrane.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/02 - Inorganic material
• C01B 37/02 - Crystalline silica-polymorphs, e.g. silicalites

Abstract

[Problem] To provide a nucleoside that is more practical for RNA pharmaceuticals and other applications and a use therefor. [Solution] A nucleoside derivative indicated by formula (1) or (2) or a salt thereof. (In formula (1), R1 indicates a hydrogen atom, a hydroxyl group, a hydroxyl group having a hydrogen atom substituted by an alkyl group or an alkenyl group, or a protected group. In formula (2), X indicates a halogen atom. In formulas (1) and (2), R2 and R4 can be the same or different and indicate a hydrogen atom, a protecting group for a hydroxyl group, a phosphate group, a protected phosphate group, or –P(=0)nR5R6 (n indicates 0 or 1 and R5 and R6 can be the same or different and indicate either a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a thiol group, a protected thiol group, a lower alkoxy group, a cyano lower alkoxy group, an amino group, or a substituted amino group. When n is 1, however, R5 and R6 are never both hydrogen atoms.) R3 indicates NHR7 having a linking group for each (R7 indicating a hydrogen atom, an alkyl group, an alkenyl group, or a protecting group for an amino group), an azide group, an amidino group, or a guanidino group. B indicates a purine-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purine-9-il group, or a substituted 2-oxo-pyrimidin-1-yl group.)

IPC Classes  ?

• C07H 19/06 - Pyrimidine radicals
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/09 - Recombinant DNA-technology

Abstract

Provided is a novel antibody against a prorenin receptor or an antigen-binding fragment of the antibody, which can detect a prorenin receptor. The antibody against a prorenin receptor or an antigen-binding fragment of the antibody according to the present invention is characterized by being capable of binding to a prorenin receptor, and is also characterized by comprising a heavy-chain variable region and a light-chain variable region, wherein the combination of the heavy-chain variable region and the light-chain variable region is as follows: the heavy-chain variable region contains the amino acid sequences (H1-a1), (H2-a1) and (H3-a1) and the light-chain variable region contains the amino acid sequences (L1-a1), (L2-a1) and (L3-a1).

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• C07K 16/46 - Hybrid immunoglobulins
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 15/09 - Recombinant DNA-technology
• C12P 21/08 - Monoclonal antibodies

Abstract

[Problem] To provide a double-stranded nucleic acid molecule exhibiting excellent antitumor activity. [Solution] A double-stranded nucleic acid molecule containing a first polynucleotide chain which includes a base sequence represented by chemical formula (1) (SEQ ID NO: 1), and a second polynucleotide chain which includes a complementary base sequence to the first polynucleotide chain.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present invention addresses the problem of providing a technology that is useful for the progress in reproductive medicine and fertilized egg transplantation. Provided are: a sperm activator that contains, as an active ingredient, a material obtained by crushing at least one type of cells selected from the group consisting of fat tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord-derived stem cells; and an artificial insemination method using the sperm activator.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 35/35 - Fat tissueAdipocytesStromal cellsConnective tissues
• A61K 35/51 - Umbilical cordUmbilical cord bloodUmbilical stem cells
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61K 35/54 - OvariesOvaOvulesEmbryosFoetal cellsGerm cells
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Abstract

Provided is a graft material for treating nerve damage, the graft material including dental pulp cells, wherein properties required of dental pulp cells provided as a graft material for treating nerve damage are identified. The present invention pertains to a graft material for treating nerve damage, the graft material including dental pulp cells in which GABRB1 genes are expressed and which are resistant to active oxygen.

IPC Classes  ?

• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61L 27/00 - Materials for prostheses or for coating prostheses
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

An energy carrier system is provided that produces ammonia with high efficiency and that further produces hydrogen as final product and uses the hydrogen as energy. An energy storage transportation method is further provided that is carried out by using energy carrier system. The energy carrier system includes nitric acid production device, an ammonia production device, and hydrogen production device. The nitric acid production device includes a photo-reactor, a gas supply unit that supplies photo-reactor with gas to be treated containing a nitrogen oxide, water, and oxygen, and light source disposed in the photo-reactor. The light source radiates light including ultraviolet of a wavelength shorter than 175 nm. The energy storage transportation method includes nitric acid production step of producing nitric acid from a nitrogen oxide, ammonia production step of producing ammonia through reduction of nitric acid, and hydrogen production step of producing hydrogen through decomposition of the ammonia.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 21/40 - Preparation by absorption of oxides of nitrogen
• C01C 1/02 - Preparation or separation of ammonia
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
• C01B 21/38 - Nitric acid

Abstract

[Problem] To provide 11C-labelled O6-benzylguanine with which PET images can be obtained, and a production method therefor. [Solution] This 11C-labelled O6-benzylguanine is characterized by being represented by chemical formula (a). The compound is obtained by performing: a coupling step in which 11C-labelled methyl iodide and an organic tin compound (b) (with the caveat that, in chemical formula (b), R1 represents an alkyl group, and R2 and R3 represent elimination groups which are capable of being eliminated by bases) in an aprotic lactam are cross-coupled in the presence of a palladium complex and a phosphine ligand; and an elimination step in which elimination groups R2 and R3 of the cross-coupling product obtained as a result of the coupling step are eliminated by bases.

IPC Classes  ?

• C07D 473/18 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07B 61/00 - Other general methods

Abstract

The present invention makes it possible to provide good grasping performance with low energy consumption. A hand robot control method comprises: a first step of causing, by energizing a plurality of motors for the fingers in a prescribed order, each joint corresponding to a motor to bend; a second step of placing a joint into a locked state with a one-way power transmission mechanism each time a detection is made by a tactile sensor means by de-energizing the motor of the joint corresponding to that tactile sensor means that has made the detection; a third step of causing the joint corresponding to the motor to bend by energizing the prescribed motor under the condition that all motors are de-energized; and a fourth step of placing all joints in a locked state by de-energizing all motors including the prescribed motor under the condition that the grasping force based on a detected value of the tactile sensor means is a target grasping force.

IPC Classes  ?

• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B25J 15/08 - Gripping heads having finger members

Abstract

Provided is a novel prophylactic or therapeutic agent for various diseases caused by IL-18 activity, more specifically, a medicine that comprises a peptide selected from the group consisting of (a) to (c) or a salt thereof: (a) a peptide containing an amino acid sequence represented by SEQ ID NO:1; (b) a peptide containing an amino acid sequence having at least 60% identity to the amino acid sequence represented by SEQ ID NO:1 and having an effect of inhibiting IL-18 activity; and (c) a peptide having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution, insertion and/or addition of one or more amino acid residues and having an effect of inhibiting IL-18 activity.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 14/54 - Interleukins [IL]
• C12N 15/09 - Recombinant DNA-technology

Abstract

Provided is a nucleoside derivative represented by formula (1). (In formula (1), Y represents an unfused aromatic or heterocyclic hydrocarbon group or a fused polycyclic based hydrocarbon group, W1 represents a hydrogen atom, a hydroxyl group-protecting group, or a phosphate ester group, W2 represents a hydrogen atom, a hydroxyl group-protecting group, or a phosphate ester group, and R1, R2, and R3 each independently represent a hydrogen atom or a linear saturated hydrocarbon group having 1-4 carbon atoms.)

IPC Classes  ?

• C07D 239/47 - One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 239/54 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
• C07D 473/18 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
• C07D 473/34 - Nitrogen atom attached in position 6, e.g. adenine
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/09 - Recombinant DNA-technology

Abstract

[Problem] To provide a shaft that is lightweight and has excellent strength. [Solution] A shaft 6 has one or a plurality of fiber-reinforced resin layers. At least one of the fiber-reinforced resin layers is manufactured by the filament winding method in which one or a plurality of fiber bundles are wound while applying tension. Each fiber bundle includes a plurality of filaments. The tension applied to the fiber bundle is at least 0.04 gf per filament. This tension is high. Preferably, at least one of the fiber-reinforced resin layers is manufactured by the multi-filament winding method, in which a plurality of the fiber bundles are simultaneously wound while being disposed in parallel. Preferably, the fiber constituting the filament is carbon fiber. Preferably, the resin composition included in the fiber-reinforced resin layer is an epoxy resin composition.

IPC Classes  ?

• A63B 53/10 - Non-metallic shafts

Abstract

A denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device is provided with a combustion chamber, a denitration agent feed means for feeding a denitration agent into the combustion chamber, an exhaust pipe, and an OH-radical-generating substance feed means for feeding an OH radical-generating substance into the exhaust pipe. The denitration agent feed means feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe to perform a second denitration reaction step.

IPC Classes  ?

• B01D 53/92 - Chemical or biological purification of waste gases of engine exhaust gases
• B01D 53/79 - Injecting reactants
• B01D 53/76 - Gas phase processes, e.g. by using aerosols
• B01D 53/56 - Nitrogen oxides
• F23J 7/00 - Arrangement of devices for supplying chemicals to fire
• F23G 7/06 - Methods or apparatus, e.g. incinerators, specially adapted for combustion of specific waste or low grade fuels, e.g. chemicals of waste gases or noxious gases, e.g. exhaust gases
• F23J 15/00 - Arrangements of devices for treating smoke or fumes

Abstract

[Problem] To provide a novel oligonucleotide derivative that is easy to synthesize and can be introduced into cells without using a lipofection reagent. [Solution] The oligonucleotide derivative of the present invention is shown by, e.g., (1). This derivative is considered to bind an aminoglycan moiety to a ligand on the surface of a cell and be introduced into the cell, and can be expected to have selective drug delivery functions. In the formula, R1 and R2 each independently represent a hydrogen or phosphate group; a, b, and c independently represent integers of 0 or higher, at least one of a, b, and c being 1 or higher; A and B independently represent optionally modified oligonucleotides having a combined chain length of A and B of 3 or higher. However, A and B do not include hydroxyl groups at the 3' end and 5' end of the oligonucleotide. Furthermore, S in the formula indicates a sugar substituent, a peptide chain, or a tocopherol binding group. Additionally, an alkyl group may be bonded, in lieu of hydrogen, to the benzene ring in the formula.

IPC Classes  ?

• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided are: an energy carrier system which produces ammonia with high efficiency, and eventually produces hydrogen from the ammonia and uses the same as energy; and an energy storage transportation method using the system. This energy carrier system comprises nitric acid production means, ammonia production means, and hydrogen production means. The nitric acid production means includes: a photoreactor; a processed gas supplying means which supplies a processed gas containing nitrogen oxide, water, and oxygen to the photoreactor; and a light source which is disposed inside the photoreactor and generates light that includes ultraviolet rays with a wavelength of less than 175 nm. This energy storage transportation method comprises: a nitric acid production step of producing nitric acid from nitrogen oxide; an ammonia production step of producing ammonia by reducing the nitric acid; and a hydrogen production step of producing hydrogen by decomposing the ammonia.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 21/40 - Preparation by absorption of oxides of nitrogen
• C01C 1/02 - Preparation or separation of ammonia

Abstract

[Problem] To provide a new tetrazole derivative and antiviral agent targeting the RNA polymerase of a virus. [Solution] An antiviral agent according to the present invention is characterized by comprising, as an active ingredient, a tetrazole derivative represented by chemical formula (1), or a pharmaceutically acceptable salt, hydrate or solvate thereof. In formula (1), R1 represents an alkylbenzene substituent group, a halogenated benzene substituent group or (1-a), and X represents O-R2 or (1-b) (therein, R2 represents an alkenyl group or an alkyl group having four or less carbon atoms, and R3 an R4 each independently represent a hydrogen atom, an alkyl group, an alkenyl group, an aromatic substituent group or a heteroaromatic substituent group).

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/074 - Adult stem cells

Abstract

　The present invention provides a highly safe composition for suppressing cancer cell proliferation (composition for preventing/treating cancer). This composition for suppressing cancer cell proliferation includes a green tea extract and a rosemary extract at a weight ratio (mixture weight ratio of green tea extract : rosemary extract) of 10:1 to 1:10.

IPC Classes  ?

• A61K 36/82 - Theaceae (Tea family), e.g. camellia
• A23K 20/00 - Accessory food factors for animal feeding-stuffs
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A braider and a tube body in which braids are arranged on an outer peripheral surface of a mandrel uniformly even if the diameter of the mandrel is uneven. A braider 1 has bobbin carrier conveyance mechanisms 50A and 50B in which bobbin carriers 40A and 40B are conveyed from traveling tracks W1 and W2 to an outside of the traveling tracks W1 and W2 so as to stop winding of braids Y1 and Y2 onto a mandrel 2 and the bobbin carriers 40A and 40B are conveyed from the outside of the traveling tracks W1 and W2 to the traveling tracks W1 and W2 so as to start the winding of the braids Y1 and Y2 onto the mandrel 2.

IPC Classes  ?

• D04C 1/06 - Braid or lace serving particular purposes
• D04C 3/48 - Auxiliary devices
• D04C 3/18 - Spool carriers for vertical spools
• D04C 3/28 - Devices for controlling spool carriers to obtain patterns, e.g. devices on guides or track plates by stopping only the spool carrier

Abstract

To provide a hydrogen generating apparatus that efficiently generates hydrogen from ammonia, and a fuel cell system that generates power using the efficiently generated hydrogen. [Solution] A hydrogen generating apparatus (1) is provided with a plasma reactor (3), a high-voltage electrode (5), a grounding electrode (7), and a gas supply means (15) that supplies a gas containing ammonia to the plasma reactor. The high-voltage electrode (5) is configured with a hydrogen separation membrane (12) included therein. Under the conditions of room temperature and atmospheric pressure, the hydrogen separation membrane (12) of the high-voltage electrode (5) discharges electricity between the grounding electrode (7) and the hydrogen separation membrane with power supplied from a high-voltage pulse power supply (2), and hydrogen is generated by bringing into the plasma state the ammonia contained in the gas thus supplied.

IPC Classes  ?

• B01J 19/18 - Stationary reactors having moving elements inside
• H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues
• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 3/50 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification
• H01M 8/0606 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants
• H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion

Abstract

The problem addressed by the present invention is to provide an anti-prion compound having high crystallinity and high crystal stability, and to provide an agent for the prevention, amelioration, and treatment of prion disease. The present invention is a maleate of the compound represented in formula (1).

IPC Classes  ?

• C07D 295/14 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

　Provided is a device for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphology index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. A device for assisting in the diagnosis of osteoporosis, wherein the device has an outline extraction unit for extracting a mandibular bone outline from an image of a mandibular cortical bone captured by an imaging device for capturing an image of the mandibular cortical bone and the surroundings thereof, a line segment extraction unit for extracting a line segment from the image of the mandibular cortical bone captured by the imaging device, and a cortical bone state calculator or a cortical bone morphology indicator identification unit for calculating the state of the cortical bone on the basis of the extracted mandibular bone outline and line segment.

IPC Classes  ?

• A61B 6/14 - Applications or adaptations for dentistry
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

　To apply a denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device (100) is provided with a combustion chamber (1), a denitration agent feed means (11) for feeding a denitration agent into the combustion chamber (1), an exhaust pipe (2), and an OH-radical-generating substance feed means (21) for feeding an OH-radical-generating substance into the exhaust pipe (2). The denitration agent feed means (11) feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means (21) feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe (2) to perform a second denitration reaction step.

IPC Classes  ?

• B01D 53/56 - Nitrogen oxides
• F23G 7/06 - Methods or apparatus, e.g. incinerators, specially adapted for combustion of specific waste or low grade fuels, e.g. chemicals of waste gases or noxious gases, e.g. exhaust gases
• F23J 7/00 - Arrangement of devices for supplying chemicals to fire
• F23J 15/00 - Arrangements of devices for treating smoke or fumes

Abstract

The purpose of the present invention is to provide: a formate dehydrogenase having a high specific activity; and a method for producing a formate dehydrogenase with high efficiency without using methanol. The present invention relates to: a novel formate dehydrogenase; a gene encoding the formate dehydrogenase; a method for producing the formate dehydrogenase; and a method for regenerating a coenzyme using the formate dehydrogenase.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12P 19/38 - Nucleosides

Abstract

　A nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) is introduced into a cell, and an iPS cell is produced.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

This molding jig manufacturing method (1) is provided with: a molten film forming step (S1) for forming a mold release film (3) on a substrate surface (6a) of a substrate (6) by applying a powdery PTFE resin (7) to the substrate surface (6a) and heating the resin, said substrate being a substrate on which a film is to be formed; a plasma modifying step (S2) as a surface modifying step for irradiating a film surface (3a) of the mold release film (3) with plasma; a prepreg laminating step (S3) for laminating, on a modified film surface (3b) of the mold release film (3), a sheet-like prepreg (4) configured from a carbon fiber; and a firing step (S4) for performing firing in a state wherein the mold release film (3) and the prepreg (4) are laminated.

IPC Classes  ?

• B29C 70/06 - Fibrous reinforcements only

Abstract

Provided is an RNA interference agent having a simple structure, and with which it possible to obtain an effect of suppressing an off-target effect. In order to achieve this aim, the present invention is an RNA interference agent, comprising one or more PAZ domain low-affinity units on the 3' terminal, and provided with a single-strand oligonucleotide as a passenger strand.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

Provided are: a redox pair which does not have strong absorption in a visible region unlike a iodine redox pair, can be sealed readily, and has high performance; and a photoelectric conversion element which is produced using the redox pair and has high practical availability. A redox pair composed of a compound represented by general formula (1) and a compound represented by general formula (2) is used. In general formula (1), A represents Li, K, Na, an ammonium compound, an imidazolium compound or a pyrrolidinium compound. In general formulae (1) and (2), R1 represents a linear alkyl group having 4 to 8 carbon atoms, wherein multiple R1's are the same as or different from each other or some or all of the multiple R1's are different from each other. AA General formula

IPC Classes  ?

• H01M 14/00 - Electrochemical current or voltage generators not provided for in groups Manufacture thereof
• C07D 207/06 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
• C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
• C07D 257/04 - Five-membered rings
• H01L 31/04 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices

Abstract

The present invention provides a technique for impregnating a continuous fiber with a thermoplastic resin having a high melt viscosity in a short time, and thereby enables short-cycle molding of a continuous-fiber-reinforced thermoplastic resin composite material. The present invention pertains to a reinforcing fiber/resin fiber composite (10) which is to be used for the production of a continuous-fiber-reinforced thermoplastic resin composite material and which is characterized in that: the composite (10) comprises a continuous fiber bundle (1) and a thermoplastic resin fiber (cover (2)) which covers the periphery of the continuous fiber bundle (1) in such a state that the continuous fiber bundle (1) is not constricted; and the continuous fiber bundle (1) can be flattened. The present invention also pertains to a process for manufacturing the same.

IPC Classes  ?

• C08J 5/04 - Reinforcing macromolecular compounds with loose or coherent fibrous material
• B29B 11/16 - Making preforms characterised by structure or composition comprising fillers or reinforcements
• B29C 70/06 - Fibrous reinforcements only
• D03D 1/00 - Woven fabrics designed to make specified articles
• D03D 3/02 - Tubular fabrics
• D04B 1/22 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes specially adapted for knitting goods of particular configuration
• D04B 21/20 - Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
• D04C 1/12 - Cords, lines, or tows

Abstract

[Problem] To provide a hydrogen generating apparatus that efficiently generates hydrogen from ammonia, and a fuel cell system that generates power using the efficiently generated hydrogen. [Solution] A hydrogen generating apparatus (1) is provided with a plasma reactor (3), a high-voltage electrode (5), a grounding electrode (7), and a gas supply means (15) that supplies a gas containing ammonia to the plasma reactor. The high-voltage electrode (5) is configured with a hydrogen separation membrane (12) included therein. Under the conditions of room temperature and atmospheric pressure, the hydrogen separation membrane (12) of the high-voltage electrode (5) discharges electricity between the grounding electrode (7) and the hydrogen separation membrane with power supplied from a high-voltage pulse power supply (2), and hydrogen is generated by bringing into the plasma state the ammonia contained in the gas thus supplied.

IPC Classes  ?

• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C01B 3/56 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification by contacting with solidsRegeneration of used solids
• H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues

Abstract

　Provided is a new cancer marker for testing the morbidity risk of cancer.　The cancer marker of this invention is a prorenin receptor. The method for testing the morbidity risk of cancer of this invention is a method which measures the expression of prorenin receptors in a biological sample of a subject, and further includes, for example, a step in which the morbidity risk of cancer of the subject is tested by comparing the level of expression of prorenin receptors in the biological sample of the subject with a reference value. The reference value is the level of expression of prorenin receptors in the biological sample of healthy subjects or the level of expression of prorenin receptors in the biological samples of cancer patients. If the level of expression in the subject is higher than the level of expression in a healthy subject, is the same as the level of expression in the cancer patient, or is higher than the level of expression in the cancer patient, the subject is deemed to have a risk of dying from cancer.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 35/00 - Antineoplastic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The purpose of the present invention is to provide a new medical application using pluripotent stem cells (Muse cells) for regenerative medicine. The present invention provides a cell formulation for treating myocardial infarctions, especially severe, large-scale myocardial infarctions, and accompanying heart failure. Said cell formulation contains SSEA3-positive pluripotent stem cells isolated from either mesenchymal tissue from an organism or cultured mesenchymal cells. This cell formulation is based on the following myocardial-tissue regeneration mechanism: intravenous administration of Muse cells to subjects with the abovementioned disorders results in said Muse cells selectively accumulating in the damaged myocardial tissue and, within said tissue, differentiating into cardiac muscle.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

The purpose of the present invention is to provide a new medical application using pluripotent stem cells (Muse cells) for regenerative medicine. The present invention provides a cell formulation for treating myocardial infarctions, especially severe, large-scale myocardial infarctions, and accompanying heart failure. Said cell formulation contains SSEA3-positive pluripotent stem cells isolated from either mesenchymal tissue from an organism or cultured mesenchymal cells. This cell formulation is based on the following myocardial-tissue regeneration mechanism: intravenous administration of Muse cells to subjects with the abovementioned disorders results in said Muse cells selectively accumulating in the damaged myocardial tissue and, within said tissue, differentiating into cardiac muscle.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/0789 - Stem cellsMultipotent progenitor cells

Abstract

[Problem] The present invention addresses the problem of providing a method for rapidly methylating sp3 carbon under conditions having a low [11C]CH3I concentration, which is applicable to the methylation of [11C]. [Solution] The method for methylating sp3 carbon according to the present invention is characterized by cross-coupling a boronic acid ester compound in which a carbon atom at an allyl position or a benzyl position has been esterified with boronic acid and methyl iodide in an aprotic polar solvent such as DMF under such a condition that a palladium complex represented by general formula Pd[PR1R2R3]2 (wherein at least one of three substituents R1, R2 and R3 is an alkyl group) and a base are present. It is preferred that the aprotic polar solvent contains water. Examples of the compounds represented by general formula Pd[PR1R2R3]2 include Pd[P(tert-C4H9)3]2 and others.

IPC Classes  ?

• C07C 1/32 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero atoms other than, or in addition to, oxygen or halogen
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07C 15/073 - Ethylbenzene
• C07B 61/00 - Other general methods

Abstract

A diagnosis support system includes a diagnosis support computer that includes a model data acquisition unit configured to obtain a plurality of mandible model data, a contour model creation unit configured to create contour model data from the mandible model data, a contour database storage unit configured to construct a contour model database from the contour model data, a diagnosis image data receiving unit configured to receive an input of diagnosis image data of an examinee, an edge extraction unit configured to extract edge data from the diagnosis image data, a similar model searching unit configured to search contour model data based on the edge data, a position judgment unit and an image quality judgment unit configured to judge an imaging position and an image quality based on imaging information, respectively, and a diagnosis support information provision unit configured to provide diagnosis support information based on provider information.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/14 - Applications or adaptations for dentistry
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

The present invention addresses the issue of providing a method which enables the identification and quantification of types of animal hair from a sample containing animal hair by directly analyzing protein which is the main component of animal hair, rather than using DNA which is present in small quantities.　The present invention provides a method in which mass spectrometry of an animal hair sample is carried out, enabling, as a result of the analysis, the mass, mass/charge ratio (m/z), LC elution time for the mass/charge ratio, and a partial sequence useful as a marker to be identified for protein components such as keratin which are the main protein components of animal hair, and types of animal hair to be identified and quantified on the basis of these results.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• C07K 5/00 - Peptides having up to four amino acids in a fully defined sequenceDerivatives thereof
• C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
• G01N 33/483 - Physical analysis of biological material

Abstract

Provided is a medicinal composition for treating infarction, such as myocardial infarction and cerebral infarction, using a method that is different from conventional therapeutic methods with the use of a thrombolytic agent or balloon therapy. An autophagy enhancer such as hsa-miR-145 is used as the active ingredient of the medicinal composition for treating infarction. In particular, an autophagy enhancer such as hsa-miR-145 being in a liposomal form is used as the active ingredient of the medicinal composition for treating infarction.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

　Provided are a gas treatment device and a gas treatment method which can reduce nitrogen oxides in gas which is to be treated, reliably and with low processing-costs.　This gas treatment method for reducing nitrogen oxides in nitrogen oxide-containing gas which is to be treated is characterised by irradiating ultraviolet light from an ultraviolet light radiating lamp onto a mixed gas of a carrier gas and a raw material gas which can generate ammonia radicals, thus generating ammonia radicals, and then mixing the ammonia radicals into the gas which is to be treated, thus reducing the nitrogen oxides in the gas which is to be treated.

IPC Classes  ?

• B01D 53/56 - Nitrogen oxides
• B01D 53/74 - General processes for purification of waste gasesApparatus or devices specially adapted therefor

Abstract

The present invention relates to the following: a complex compound which has an imidazo[1,5-a]pyridine derivative, characterized in being represented by general formula (I), as the ligand; a method for synthesizing the same; and the use of the complex compound. The complex compound is obtained by a simplified production method from readily available starting materials.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07F 5/02 - Boron compounds
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• B01J 31/22 - Organic complexes
• C07B 61/00 - Other general methods
• C07F 7/08 - Compounds having one or more C—Si linkages
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)

Abstract

A Helmholtz resonance container (110) for enabling the volume of an object to be measured in a noncontact manner using Helmholtz resonance in a liquid comprises: a container (130) having a sealable opening (132); a neck (138) having a lower end communicating with a hollow portion inside the container (130) and an open upper end; and a cover member (140) provided at the upper end of the neck (138) and having an opening communicating with the inside of the neck (138). An edge of the opening (112) of the cover member (140) forms a reed (152) for generating sound and becomes thinner as approaching the opening. Sound is generated by the reed (152) by hitting a water current against the reed (152) from a water pipe (118), and in response to this sound, Helmholtz resonance is generated in the container (110). The volume of the object can be measured by a predetermined functional relation by putting the object in the container (130) and checking the peak frequency of the Helmholtz resonance.

IPC Classes  ?

• G01F 17/00 - Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
• A01K 61/00 - Culture of aquatic animals

Abstract

Provided are a device (10) and a method for measuring the crispness of a food product. An item to be measured (22) comprising a porous food product is broken apart by causing the blade of a knife (14) to penetrate into the item. A vibration detector (18) attached to the knife (14) detects crack vibrations from cracks that form when the item to be measured (22) is broken apart. In a computer (20), the small crack vibrations of a predetermined vibration power or less that are included in the crack vibrations within an individual cracking duration time are extracted from the detected crack vibrations. Crispness is measured on the basis of the number of extracted small crack vibrations counted (number of cracks).

IPC Classes  ?

• G01N 19/00 - Investigating materials by mechanical methods
• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G01N 3/40 - Investigating hardness or rebound hardness
• G01N 29/46 - Processing the detected response signal by spectral analysis, e.g. Fourier analysis
• G01N 33/02 - Food

Abstract

A compound represented by formula (I) has an excellent noxious organism control activity. [R1 represents a C1-8 alkyl group or the like; W represents a halogen atom or the like; n represents an integer of 0 to 4; A represents a bicycic to tricyclic condensed aromatic hetero ring containing at least one nitrogen atom, or the like; and B represents a 5- to 6-membered aromatic hetero ring which is bound to a nitrogen atom in A.]

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• A01P 7/02 - Acaricides
• A01P 7/04 - Insecticides
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61P 33/00 - Antiparasitic agents
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
• C07D 495/04 - Ortho-condensed systems

Abstract

The present invention provides a compound represented by general formula (1). In general formula (1): G represents a hexose-6-phosphate group; and L represents a divalent linker group.

IPC Classes  ?

• C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

　Although competitive detection methods are generally considered to be effective as a simplified method of detecting sugar chains, such methods are unsuited to quantitative determination. Provided is a sugar chain detection method that resolves such issues encountered when using conventional techniques.　The method for detecting sugar chains using a molecular probe that can bind specifically to the sugar chains comprises bringing into contact with a specimen a substance that labels the molecular probe using a photocrosslinking agent that can bind to the sugar chains, and then irradiating the specimen with light and crosslinking the sugar chains which have specifically binded to the molecular probes. A kit for detecting sugar chains contains (a) and (b) below. (a) A photocrosslinking agent and molecular probe that can bind to the sugar chains (b) A molecular probe that is labelled using a crosslinking agent that can bind to the sugar chains Provided are a screening method for substances that bind specifically to a sugar chain, and a kit therefor, and a disease testing method in which the sugar chain acts as a diagnostic marker, and a kit therefor.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

[Problem] To provide a canine madness vaccine which is higly safe, effective and inexpensive. [Solution] Provided are: a mutant canine madness virus (e.g., strain ERA-N273/394-G333 shown in fig. 2) which has at least the following mutations in a structural protein of a canine madness virus, i.e., the mutation of the amino acid reside at position-273 in N protein into an amino acid residue other than phenylalanine, the mutations of the amino acid reside at position-394 in N protein into an amino acid residue other than tyrosine, and the mutation of the amino acid residue at position-333 in G protein into an amino acid residue other than arginine or lysine; a canine madness vaccine preparation containing the mutant canine madness virus; and others. The introduction of the mutation of the amino acid residue at position-333 in G protein induces the attenuation of the virulence of a canine madness virus, and the introduction of the mutations of the amino acid residues at position-273 and position-394 in N protein induces the improvement in immunogenicity and safety of the canine madness virus. In addition, the introduction of the mutations of the amino acid residues at position-273 and position-394 in N protein enables the prevention of the increase in the virulence of the canine madness virus even when the mutation of the amino acid residue at position-194 in G protein into lysine occurs and, as a result, the possibility of the occurrence of reversion of pathogenicity of the canine madness virus caused by mutation can be reduced and the safety of the canine madness virus can be further improved.

IPC Classes  ?

• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• A61K 39/205 - Rhabdoviridae, e.g. rabies virus
• A61P 31/12 - Antivirals
• C12N 15/09 - Recombinant DNA-technology

Abstract

The objective of the present invention is to provide: a uracil-requiring Moorella bacteria resulting from destroying the gene coding for orotidine-5-phosphate decarboxylase; and a transforming-gene-introduced Moorella bacteria resulting from introducing a transforming gene and a gene coding for orotidine-5-phosphate decarboxylase to the chromosome of the uracil-requiring Moorella bacteria. The objective is resolved by means of a uracil-requiring Moorella bacteria that results from destroying the gene coding for orotidine-5-phosphate decarboxylase in the chromosome of a Moorella bacteria, and that is characterized by belonging to the MTA-D-pF strain.

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/09 - Recombinant DNA-technology

Abstract

The objective of the present invention is to provide a primer set used in transformation imparting uracil-requiring properties by deleting or destroying the gene coding for orotidine-5-phosphate decarboxylase in a Moorella bacteria. The objective was resolved by means of a primer set that is used when producing a uracil-requiring strain of which the gene coding for orotidine-5-phosphate decarboxylase has been deleted or destroyed by means of homologous recombination in a Moorella bacteria, and that is characterized by being represented by sequence number 1 and sequence number 2, which amplify the upstream region neighboring the gene coding for orotidine-5-phosphate decarboxylase.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material

Abstract

The endoscopic treatment instrument is equipped with a pliable flexible sheath, an operating wire inserted to be freely advancible and retractable in said flexible sheath, a basket provided on the distal end of said operating wire and configured from multiple elastic wires, and a clasp provided at the distal ends of said elastic wires to tie the multiple elastic wires together. The region of said basket of maximum diameter in the radial direction is located closer to the clasp than the midway point in the central axial direction between the proximal end of the basket and the clasp. Each of the multiple elastic wires has a helical shape that is wound in the same direction over the entire length thereof and the winding pitch becomes gradually smaller when moving from the distal end of the operating wire towards the clasp.

IPC Classes  ?

• A61B 17/221 - Calculus gripping devices in the form of loops or baskets

Abstract

The diagnosis assistance system (1) is equipped with a diagnosis assistance computer (3) comprising: a model data-acquiring means (14) for acquiring multiple mandible model data (9); a contour model-generating means (16) for generating contour model data (15) from the mandible model data; a contour database storage means (20) for building a contour model database (19) from the contour model data (15), etc.; a diagnostic image data-receiving means (21) for receiving input of a subject's diagnostic image data (6); an edge-extracting means (23) for extracting edge data (22) from the diagnostic image data (6); a similar model-retrieving means (24) for retrieving similar contour model data (15) on the basis of the edge data (22); a position-assessing means (25) and image quality-assessing means (26) for assessing imaging position, etc. and image quality on the basis of imaging information (17); and a diagnosis-assisting information-providing means (27) for providing diagnosis-assisting information (7) on the basis of donor information (18).

IPC Classes  ?

• A61B 6/14 - Applications or adaptations for dentistry
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

Provided are: a compound which has heptamethine structure and which is to be used as a sensitizing dye in a photoelectric conversion element, said compound being represented by formula (1); and a photoelectric conversion element which includes the compound as the sensitizing dye and which can resolve the problems of the prior art. In formula (1), R1 and R2 are each a hydrogen atom, alkyl or aryl; R3 to R6 are each C1-12 alkyl; X is a halogen atom; Y is a monovalent anion; when R3 to R6 are each C1-5 alkyl, Z is alkyl, alkoxy or aryl, while when R3 to R6 are each C6-5 alkyl, Z is a hydrogen atom, alkyl, alkoxy or aryl; and m and n are each an integer of 1 to 12.

IPC Classes  ?

• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• C09B 23/00 - Methine or polymethine dyes, e.g. cyanine dyes
• H01L 31/04 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices
• H01M 14/00 - Electrochemical current or voltage generators not provided for in groups Manufacture thereof

Abstract

A force sense display interface comprises: haptic finger bases (16), further comprising a plurality of haptic fingers (21-25) which are capable of tracking the motion of the fingers (Ya) of the hands (Ha) of an operator (H); arm mechanisms (110) which allow spatial motion of the haptic finger bases (16); and controllers (200A, 200B) which control the arm mechanisms (110) in linkage with the position and attitude of the hands, and which control the haptic fingers (21-25) in linkage with the movements of the fingers (Ya), of the operator (H). The force sense display interface further comprises finger holders (26) for attaching the haptic fingers (21-25) on the fingers of the operator (H) in a state wherein the haptic finger bases (16) are distanced from the backs of the hands (Ha) of the operator (H) so as to be opposite the backs of the hands (Ha) thereof.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• B25J 3/00 - Manipulators of leader-follower type, i.e. both controlling unit and controlled unit perform corresponding spatial movements
• B25J 13/02 - Hand grip control means

Abstract

A finger motor (16) for driving a finger is linked to a worm reduction mechanism (17). A worm wheel (19), which is the output gear of the worm reduction mechanism (17), rotates, so that a metacarpophalangeal joint (15) bends and extends. The metacarpophalangeal joint (15) is linked through two link mechanisms consisting of a first driving link (21) and a second driving link (23) to a proximal interphalangeal joint (20) and a distal interphalangeal joint (22). This allows the proximal interphalangeal joint (20) and the distal interphalangeal joint (22) to bend and extend in conjunction with the bending and extending operations of the metacarpophalangeal joint (15).

IPC Classes  ?

• B25J 15/08 - Gripping heads having finger members
• A61F 2/56 - Artificial arms or hands or parts thereof adjustable
• A61F 2/72 - Bioelectric control, e.g. myoelectric

Abstract

Provided are a device (10) and a method for measuring the crispness of a food product. An item to be measured (22) comprising a porous food product is broken apart by causing the blade of a knife (14) to penetrate into the item. A vibration detector (18) attached to the knife (14) detects crack vibrations from cracks that form when the item to be measured (22) is broken apart. In a computer (20), the small crack vibrations of a predetermined vibration power or less that are included in the crack vibrations within an individual cracking duration time are extracted from the detected crack vibrations. Crispness is measured on the basis of the number of extracted small crack vibrations counted (number of cracks).

IPC Classes  ?

• G01N 3/30 - Investigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force
• G01N 33/02 - Food

Abstract

Disclosed is a pest control agent which uses at least one kind of imino derivative represented by chemical formula (I).

IPC Classes  ?

• A01N 43/78 - 1,3-ThiazolesHydrogenated 1,3-thiazoles
• A01N 47/18 - Carbamic acid derivatives, i.e. containing the group —O—CO—NThio-analogues thereof containing a —O—CO—N group, or a thio-analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
• A01N 47/36 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the group N—CO—N directly attached to at least one heterocyclic ringThio-analogues thereof
• A01P 5/00 - Nematocides
• A01P 7/02 - Acaricides
• A01P 7/04 - Insecticides
• C07D 277/20 - Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
• C07D 277/32 - Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

Disclosed is a hydrogen content ratio acquiring apparatus (1), wherein the values of a predetermined parameter group and reference information, which relates the content ratio of SiH contained in a silicon film to the content ratio of SiH2 contained in the silicon film, are previously generated and stored. A measured spectrum of the silicon film on a glass substrate (9) is obtained by measuring the silicon film by means of a spectroscopic ellipsometer (3), and on the basis of the measured spectrum, the values of the parameter group are obtained using a computer (6). Then, on the basis of the parameter group values and the reference information, the value of the SiH content ratio and that of the SiH2 content ratio are accurately obtained.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

A final target press distance of an upper die against a workpiece can be calculated from a single folding. An upper die is forced into a V-shaped groove by a set press distance (St1) corresponding to a set finished angle (θ1) that is set so as to be larger than a specific finished angle (θF) of a workpiece from which a load applied thereto is removed when the workpiece is brought into contact with slopes of the V-shaped groove, and a finished angle (θM) of the workpiece is measured. A target press distance (StT) is calculated such that an inclination (f1) of a first straight line and an inclination (f2) of a second straight line satisfy a predetermined relationship in an St-θ graph indicating the relationship between a press distance (St) and a finished angle (θ), where the first straight line passes through a measuring point that is defined by the measured finished angle (θM) and the set press distance (St1) and an inflection point that is defined by the specific finished angle (θF) and a specific press distance (StF) corresponding to the specific finished angle (θF), and where the second straight line passes through the inflection point and a machining point that is defined by the target press distance (StT) corresponding to a target finished angle (θT).

IPC Classes  ?

• B21D 5/02 - Bending sheet metal along straight lines, e.g. to form simple curves on press brakes without making use of clamping means

Abstract

Provided are novel imino derivatives serving as insecticidal compounds which exhibit excellent characteristics such as persistent effect and wide spectrum. The inimo derivatives are represented by general formula (A) [wherein Ar is a heterocyclic group which may have a substituent on the ring; X is a sulfur atom, CH2, or NR; R is a hydrogen atom or alkyl; Ya is selected from among C(=S)NR1R2, C(=S)SR3, C(=O)SR4, C(=S)OR4, SO2Zα and OZβ; and R1 to R4, Zα and Zβ are each a hydrogen atom or a prescribed substituent.]

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A01N 43/78 - 1,3-ThiazolesHydrogenated 1,3-thiazoles
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

Provided are a neuraminic acid derivative, which selectively inhibits virus sialidase activity but little inhibits human sialidase activity, a sialidase activity inhibitor, and an antiinfluenza drug. The aforesaid neuraminic acid derivative is characterized by comprising a compound represented by chemical formula (1), a pharmaceutically acceptable salt thereof, a hydrate of the same, a solvate of the same or a prodrug of the same. In chemical formula (1), R1 and R2 represent hydrogen, an optionally branched C1-8 alkyl group or an optionally branched C1-8 cycloalkyl group; and R3 represents hydrogen or fluorine.

IPC Classes  ?

• C07D 309/28 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Provided is an oligonucleotide derivative, the 3′ end of which is chemically modified with two skeletons selected from among benzene skeletons and pyridine skeletons. Said oligonucleotide derivative can be easily synthesized in a small number of steps. Also provided is an aromatic compound that serves as a precursor for preparing a modification carrier for synthesizing the oligonucleotide derivative. The oligonucleotide derivative and a provided oligonucleotide construct have good cell membrane permeability and excellent nuclease resistance. The aforementioned modification carrier is characterized in that the carrier is chemically modified, via a linker, with the unit represented by structural formula (a) (in which R1 through R6 each independently represent hydrogen or a non-hydrogen substituent, Z1 and Z2 each independently represent CH or nitrogen, and X represents oxygen or sulfur).

IPC Classes  ?

• C07C 275/24 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07C 335/12 - Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
• C07D 213/40 - Acylated substituent nitrogen atom
• C07F 7/10 - Compounds having one or more C—Si linkages containing nitrogen
• C07F 9/09 - Esters of phosphoric acids
• C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Disclosed are: a molecular probe which can overcome the disadvantages of the conventional techniques; and a method for detecting glycosaminoglycan using the molecular probe. Specifically disclosed are: a method for detecting glycosaminoglycan, which comprises bringing a molecular probe that comprises a substance capable of binding to glycosaminoglycan specifically and having a free thiol group into contact with a sample, adding N-(9-acridinyl)maleimide to the resulting mixture to generate a fluorescence, and measuring the fluorescence; a glycosaminoglycan detection kit which comprises a molecular probe that comprises a substance capable of binding to glycosaminoglycan specifically and having a free thiol group and N-(9-acridinyl)maleimide; a method for screening for a substance capable of binding to glycosaminoglycan specifically, and a kit for use in the method; and a method for diagnosing a disease for which glycosaminoglycan can be used as a diagnosis marker, and a kit, a molecular probe and a peptide for use in the method.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C12N 15/09 - Recombinant DNA-technology

Abstract

Provided is a composition comprising one or more kinds of RNA-enclosing carriers, said carriers being selected from among a monocyte, a macrophage and a shedding microvesicle originating in these cells. The RNA-enclosing carrier(s) in the aforesaid composition can maintain the RNA in a stable state in vivo.

IPC Classes  ?

• A61K 35/14 - BloodArtificial blood
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed is a compound which has a high affinity for a CD22 molecule in a B cell and can enhance an immune response to thereby exhibit activities including an activity of enhancing the proliferation of B cells and an activity of increasing the resistance against infectious diseases such as virus-mediated diseases. The compound is a sialic acid derivative represented by chemical formula (1) (wherein R1 and R2 independently represent an aromatic hydrocarbon group which may have a substituent) or a prodrug thereof, or a pharmaceutically acceptable salt or hydrate of the derivative or prodrug.

IPC Classes  ?

• C07H 7/027 - Keto-aldonic acids
• A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
• A61P 37/04 - Immunostimulants

Abstract

Provided is a novel compound which is capable of inhibiting the formation of an infectious prion protein via binding to a normal prion protein. Specifically provided is a compound represented by formula (1). In formula (1), X represents a carbon atom or a nitrogen atom; R1 and R2 may be either the same or different and represent a hydrogen atom, an oxygen atom, a halogen atom, a hydroxy group, a mercapto group, a cyano group, a carboxy group, a carbamoyl group, an alkoxycarbonyl group, an acyloxy group, an acyl group, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted amino group, etc.; and R3 to R6 may be either the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, etc., provided that at least one of R1 and R2 represents a group other than hydrogen atom.

IPC Classes  ?

• C07D 213/40 - Acylated substituent nitrogen atom
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 295/14 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A thiazole derivative is produced from easily available starting materials by a simplified process. The process is for producing a novel thiazole derivative represented by general formula (I), and is characterized by adding a strong base to a thioamide represented by general formula (II) and reacting the mixture with a thioformamide represented by general formula (III).

IPC Classes  ?

• C07D 277/18 - Nitrogen atoms
• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

Provided is an upper limb motion assist device capable of detecting motions in the directions of six axes by an inexpensive configuration. The upper limb motion assist device is provided with: a first detection means (52, 54, 56, 58, 60, 62) which is capable of detecting force that causes the movement of an operation portion (32) which a person to be assisted can grip and operate in each of an X-axis direction along the operation portion (32), a Y-axis direction orthogonal to the X-axis, and a Z-axis direction orthogonal to the X-Y axes; a second detection means (66, 68, 70, 72) which is disposed apart from the first detection means (52, 54, 56, 58, 60, 62) in the X-axis direction and is capable of detecting force that causes the movements of the operation portion (32) in the Y-axis direction and the Z-axis direction; a third detection means (76, 78) which is capable of detecting the rotation of the operation portion (32) about the X-axis or force that causes said rotation; and a control means (14) which is connected to the first to third detection means (52, 54, 56, 58, 60, 62, 66, 68, 70, 72, 76, 78), wherein the drive of a multijoint arm is controlled on the basis of detection signals inputted from the first to third detection means (52, 54, 56, 58, 60, 62, 66, 68, 70, 72, 76, 78).

IPC Classes  ?

• B25J 13/02 - Hand grip control means
• A61H 1/02 - Stretching or bending apparatus for exercising
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• G01L 5/16 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring several components of force

Abstract

Disclosed is a wearable motion support device which can support the motion of a user appropriately by enhancing the detection accuracy of the body motion of the user. A wearable motion support unit (SU1) comprises a first support member (10) which is fitted to the proximal body part (A2) of a joint (A1), a second support member (12) which is coupled with the first support member (10) in such a manner that the posture can be changed and is fitted to the distal body part (A3) of the joint (A1), an outer member (80) arranged on the second support member (12), and an inner member (81) which is arranged on the distal body part (A3) side of the outer member (80) in such a manner as to approach the outer member (80) or to separate therefrom and is fitted to the distal body part (A3). On the inner circumferential surface of the outer member (80), a pressure sensor which detects the magnitude of a pushing force at the time when the inner member (81) pushes the outer member (80) by the movement of the distal body part (A3) is arranged.

IPC Classes  ?

• A61F 2/68 - Operating or control means
• A61F 2/54 - Artificial arms or hands or parts thereof
• A61F 2/60 - Artificial legs or feet or parts thereof
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices