Abstract

The present invention relates to a biomarker for predicting the prognosis of colorectal cancer by using changes in expression level of NNT and/or OSBPL3, and a prognosis prediction method using same. The expression level of NNT and/or OSBPL3 is analyzed so that the prognosis of colorectal cancer patients in clinical practice can be predicted, and if the analysis is performed in combination with TNM stage, more accurate prediction can be made such that individualized and customized strategies can be designed.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to classification of liver lesions by a liver ultrasound image and, more specifically, to an artificial intelligence model for classifying liver lesions by using a liver ultrasound image, a method for constructing the model, and a method for classifying liver lesions by using the artificial intelligence model. To this end, the present invention provides a method for constructing an artificial intelligence model for classifying liver lesions by using a liver ultrasound image, the method comprising: a preparation step of excluding an image corresponding to a predetermined exclusion criterion, among a plurality of liver ultrasound images (S100); a step, executed by a computer, of receiving by the computer, the plurality of prepared liver ultrasound images as original images (S120); a step of cross-allocating the original images to a plurality of folds according to liver lesions (S140); a step of image-processing each original image for training (S160); and a step of training an artificial intelligence model by using the image-processed image (S180).

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• A61B 8/08 - Clinical applications
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

By using the biomarker of the present invention, early diagnosis of premature ovarian insufficiency is possible, diagnosis differentiating between premature ovarian insufficiency and premature ovarian insufficiency caused by Turner syndrome is possible, and a method for screening a therapeutic agent for premature ovarian insufficiency through a change in the expression of the biomarker can be provided.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to a use of a FGF5 transcript variant 2 (FGF5-v2) gene and a protein thereof for preventing or treating liver fibrosis. The FGF5-v2 fragment gene (transcript and protein expressed therefrom) according to the present invention is a mutated gene in which the amino acid sequence of fibroblast growth factor 5 (FGF5) is modified, and has the effect of inhibiting the progression and proliferation of liver fibrosis. Therefore, the FGF5-v2 is expected to prevent and treat liver fibrosis and thereby prevent the progression thereof to cirrhosis and liver cancer when administered to a patient with fatty liver through a vector (for example, AVV) or the like, and thus can be effectively used as a composition for treating liver fibrosis.

IPC Classes  ?

• C07K 14/50 - Fibroblast growth factor [FGF]
• A61K 38/18 - Growth factorsGrowth regulators
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to a novel compound and a pharmaceutical composition including same as an active ingredient for the prevention or treatment of pulmonary fibrosis. Specifically, the present invention relates to a compound represented by the following chemical formula I; a pharmaceutical composition including the compound as an active ingredient for the prevention or treatment of pulmonary fibrosis; a method for preventing or treating pulmonary fibrosis using the pharmaceutical composition; and a food composition including said compound as an active ingredient for the prevention or alleviation of pulmonary fibrosis. In chemical formula I, R is either methyl or ethenyl.

IPC Classes  ?

• C07C 333/20 - Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/13 - Nucleic acids or derivatives thereof

Abstract

Proposed is a system and method for segmentating brain in MRI images. According to an embodiment, it is possible to overcome limitations that gray matter is estimated to be smaller than the actual size in brain segmentation performed for quantitative analysis of a brain imaged by a magnetic resonance imaging (MRI) scanner and to accurately segment brain images by distinguishing dura mater and veins around the cerebellum by removing a large amount of cranial dura mater, thereby improving accuracy of brain quantitative analysis results and fundamentally increasing diagnostic accuracy for brain lesions.

IPC Classes  ?

• G06T 7/143 - SegmentationEdge detection involving probabilistic approaches, e.g. Markov random field [MRF] modelling
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to: a biomarker for predicting the prognosis of colorectal cancer by using changes in expression level of mRNA of a HSPD1 gene or a HSP60 protein encoded by these genes; and a prognosis prediction method using same. By analyzing the expression level of the HSPD1 gene or the HSP60 protein, the prognoses of colorectal cancer patients can be predicted in clinical practice, and when analysis is carried out in combination with TNM classification, more sophisticated prediction is possible and personalized strategies can be designed.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Provided are a method for providing information about the diagnosis of a gallbladder polyp and a device for providing information about the diagnosis of a gallbladder polyp using same. The method for providing information about the diagnosis of a gallbladder polyp being implemented by a processor includes the steps of receiving an ultrasound medical image including a gallbladder part of a subject, determining the pathogenesis of a gallbladder polyp in the subject using a first assessment model configured to determine the pathogenesis of a gallbladder polyp on the basis of the ultrasound medical image, and determining characteristics of the gallbladder polyp on the basis of a second assessment model configured to classify characteristics of the gallbladder polyp when the gallbladder polyp is determined in the ultrasound medical image.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06T 7/60 - Analysis of geometric attributes

Abstract

The present invention relates to a method for predicting the possibility of immunotherapy for a colorectal cancer patient. Specifically, by using a discriminant of a multiple linear model for determining the applicability of anticancer immunotherapy to obese colorectal cancer patients of the present invention, the patients are classified into two patient groups according to the type of gene mutation, and a patient group with a high immune signature is selected as a group to which immunotherapy can be applied such that it is possible to provide the benefit of providing a new treatment opportunity to obese colorectal cancer patients who have not benefited from the anticancer immunotherapy.

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 40/30 - Unsupervised data analysis
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The present invention relates to a biomarker for predicting the prognosis of colorectal cancer by using changes in expression level of NNT and/or OSBPL3, and a prognosis prediction method using same. The expression level of NNT and/or OSBPL3 is analyzed so that the prognosis of colorectal cancer patients in clinical practice can be predicted, and if the analysis is performed in combination with TNM classification, more accurate prediction can be made such that individualized and customized strategies can be designed.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention provides a method for providing information about diagnosis of cervical cancer and a device for providing information about diagnosis of cervical cancer by using same. The method for providing information about diagnosis of cervical cancer is implemented by a processor, the method comprising the steps of: receiving a cervical image including a cervical region of a subject; determining whether cervical cancer is negative or positive, by using an artificial neural network-based first disease classification model trained to classify cervical cancer as negative or positive by using a cervical image as an input; and determining a stage of cervical cancer on the basis of an artificial neural network-based second disease classification model trained to classify a stage of cervical cancer by using a cervical image classified as negative or positive as an input.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating atherosclerosis comprising a xanthine derivative as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating atherosclerosis by inhibiting the proliferation of vascular smooth muscle cells (VSMCs) induced by a platelet derived growth factor (PDGF).

IPC Classes  ?

• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

Provided is a reduction mechanism which is inserted into the body to reduce comminuted bones, the reduction mechanism being characterized by comprising: a sheet member that is stretchable and surrounds a plurality of fractured bone pieces; first fastening parts provided, respectively, at both ends of the sheet member; and a second fastening part coupled to the first fastening parts, thereby connecting both the ends of the sheet member. Accordingly, the reduction mechanism improves bone union and can enhance patient convenience.

IPC Classes  ?

• A61B 17/80 - Cortical plates
• A61B 17/84 - Fasteners therefor
• A61F 5/058 - Splints
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 10/00 - Processes of additive manufacturing
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

Abstract

The present invention relates to a method for prevention or treatment of metabolic disease, administering a composition containing bone morphogenetic protein 10 (BMP10) as an active ingredient, in which brown fat differentiation was promoted in the cells of BMP10-treated mouse embryonic mesenchymal cell line C3H10T1/T2, increased browning effects of stromal vascular fraction adipose stem cells isolated from subcutaneous adipose tissue was confirmed, and weight loss, improved insulin resistance, and changes in blood lipid levels were confirmed in a high-fat-diet-induced obese animal model. Therefore, the composition containing BMP10 as an active ingredient can be provided as a drug for the prevention or treatment of metabolic diseases, including obesity, diabetes, and dyslipidemia.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 3/06 - Antihyperlipidemics
• A23L 33/17 - Amino acids, peptides or proteins
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof

Abstract

The present invention relates to an exosome-derived microRNA biomarker for the diagnosis of premature ovarian insufficiency (POI) and use thereof. By using the biomarker of the present invention, early diagnosis of POI is possible, diagnosis differentiating between POI and POI caused by Turner syndrome is possible, and a method for screening for a therapeutic agent for POI through a change in the expression of the biomarker can be provided.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

There is provided a method for determining dementia risk factors by a server using deep learning. In this instance, the method for determining dementia risk factors includes acquiring biometric information from each subject corresponding to a first control group through a wearable device, acquiring measurement information for each subject corresponding to the first control group, deriving a first dementia risk factor based on the biometric information and the measurement information for each subject, and deriving a second dementia risk factor related to the first dementia risk factor via deep learning performed based on the biometric information related to the first dementia risk factor and control group information.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 3/08 - Learning methods
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof

Abstract

The present invention relates to a method for predicting new drug-target genes for the treatment and prevention of diseases. The present invention is specialized in first-in-class target discovery in new drug development steps, and provides a novel method to discover genes causative of various diseases in the target discovery step in which disease discovery should be carried out, and to evaluate the pharmacological regulation potential of the corresponding gene, and the present invention has the effects of reducing costs, shortening the period, and increasing the clinical success rate in the new drug development steps. In addition, the present invention has an important significance as the only target discovery platform at home and abroad that overcomes unmet needs for developing global new drugs and first-in-class new drugs.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating liver fibrosis or liver cirrhosis, comprising 8-OHdG or a pharmaceutically acceptable salt thereof, a method for preventing or treating liver fibrosis or liver cirrhosis using the same, and a food composition for ameliorating liver fibrosis or liver cirrhosis, comprising 8-hydroxydeoxyguanosine (8-OHdG) or a pharmaceutically acceptable salt thereof. As use of the pharmaceutical composition for preventing or treating liver fibrosis or liver cirrhosis can reduce levels of various markers whose expression level increases due to induced liver fibrosis, the pharmaceutical composition can be widely used in the effective prevention or treatment of liver fibrosis or liver cirrhosis induced thereby.

IPC Classes  ?

• A61K 31/708 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to a fracture detecting method implemented by a processor and provides a fracture detecting method and a device for detecting a fracture by using same, the method comprising the steps of: receiving a bone medical image for a subject; determining a fracture-suspected region in the bone medical image by using a prediction model that is configured to input a bone medical image and output a fracture region; determining an equivalent fracture region in the fracture-suspected region; and determining a fracture region by filtering off the equivalent fracture region in the fracture-suspected region.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 8/08 - Clinical applications
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a parathyroid hormone derivative in a dimeric form of a parathyroid hormone fragment and a pharmaceutical composition for the prevention or treatment of bone diseases comprising same. When administered to an animal model, the parathyroid hormone derivative in the dimeric form of the parathyroid hormone according to the present invention significantly increases bone density and enhances osteogenesis and thus can be effectively used for the treatment and prevention of bone diseases.

IPC Classes  ?

• A61K 38/29 - Parathyroid hormone, i.e. parathormoneParathyroid hormone-related peptides
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• C07K 14/635 - Parathyroid hormone, i.e. parathormoneParathyroid hormone-related peptides

Abstract

Provided are an apparatus and method for determining disease severity on the basis of medical images, according to embodiments of the present invention. According to an embodiment of the present invention, the apparatus for determining disease severity on the basis of medical images comprises: a communication unit configured to transmit/receive data; and a control unit configured to be connected to the communication unit, wherein the control unit is configured to: obtain, from an imaging device, through the communication unit, a plurality of medical images capturing images of a target part of a subject from different directions; obtain result data from each medical image, predicting a target part region by using a prediction model trained to predict a region corresponding to the target part on the basis of the plurality of medical images; and determine disease severity by using a classification model trained to classify the disease severity of the target part region on the basis of the result data.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 7/00 - Image analysis
• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Provided are an apparatus and a method for providing a medical image-based hologram according to an embodiment of the present invention. The apparatus is configured to: obtain a medical image generated by capturing a target site of an examinee; obtain a target site and suspected lesion site prediction result data from the medical image by using an artificial neural network model trained to predict a target site and a suspected lesion site suspected of a lesion in the target site on the basis of the obtained medical image; generate a three-dimensional image representing the target site and the suspected lesion site on the basis of the result data; generate a hologram image used for generating a hologram by using the generated three-dimensional image; and provide the generated hologram image to a hologram device so that the hologram device generates a hologram.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention provides a surgical region monitoring method which is implemented by a processor and a device for monitoring a surgical region by using same, the surgical region monitoring method comprising the steps of: receiving a medical image including a surgical region of a subject; determining whether the surgical region is abnormal by using a prediction model configured to use the medical image as an input to predict abnormal blood flow; and providing an indication of whether the surgical region is abnormal.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• A61B 5/026 - Measuring blood flow
• A61B 90/90 - Identification means for patients or instruments, e.g. tags

Abstract

Disclosed is a method for producing of 2-[18F]fluoro-4-boronophenylalanine comprising radioisotopes ([18F]FBPA), the method having a precursor with an effective leaving group and reaction conditions for high-yield synthesis of [18F]FBPA to allow the target compound, [18F]FBPA, to be efficiently synthesized, and same can be mass produced using automated synthesis apparatuses to allow effective use in molecular imaging technology.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C07B 59/00 - Introduction of isotopes of elements into organic compounds

Abstract

The present invention relates to a composition for the prevention or treatment of metabolic disease, containing bone morphogenetic protein 10 (BMP10) as an active ingredient, in which brown fat proliferation was promoted in the cells of BMP10-treated mouse embryonic mesenchymal cell line C3H10T1/T2, increased conversion to brown fat from stromal vascular fraction adipose stem cells isolated from subcutaneous adipose tissue was confirmed, and weight loss, improved insulin resistance, and changes in blood lipid levels were confirmed in a high-fat-diet-induced obese animal model. Therefore, the composition containing BMP10 as an active ingredient can be provided as a drug for the prevention or treatment of metabolic diseases, including obesity, diabetes, and dyslipidemia.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 3/06 - Antihyperlipidemics
• A23L 33/17 - Amino acids, peptides or proteins

Abstract

The radioactive liposome nanoparticles for macrophage tracing, derived via the present invention, are considered to be very usefully employed in the diagnosis of a tumor or brain inflammation by quantifying, using PET, activated macrophages (microglial cells) spread in the area of inflammation in the body. In addition, a method using late-stage radioisotopic labeling minimizes the exposure of a worker to radiation, allows mass production, and thus can be easily put to practical use in the medical industry.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The present invention relates to a use of HDAC6 as a preventive or therapeutic agent for TDP-43 proteinopathy, and more specifically, to: a pharmaceutical composition for preventing or treating TDP-43 proteinopathy, the composition comprising, as an active ingredient, the histone deacetylase 6 (HDAC6) protein or a polynucleotide encoding same; and a pharmaceutical composition for preventing or treating mitochondrial disorder encephalopathies mediated by neurotoxicity caused by the abnormal aggregation of TDP-43 or accumulation of TDP-43 in the cytoplasm due to the mislocalization thereof. The present invention also relates to a screening method of a drug for preventing or treating TDP-43 proteinopathy, the method comprising: a step for bringing a sample to be analyzed into contact with a cell under conditions in which the ubiquitin-proteasome system (UPS) is damaged, the cell comprising an expression vector containing a histone deacetylase 6 (HDAC6) protein or a polynucleotide encoding the HDAC6 protein; a step for measuring the expression level or activity of the HDAC6; and a step for determining the sample as being a drug that can prevent or treat TDP-43 proteinopathy, when the expression level or activity of HDAC6 is measured and found to have increased.

IPC Classes  ?

• A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/16 - Anti-Parkinson drugs
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes

Abstract

Provided are a method and device for discovering a target, wherein candidate targets of a disease-causing gene or a disease treatment material for a specific disease are extracted using an artificial intelligence model, and a recommended target is selected by analyzing each of the candidate targets. A target discovery method using artificial intelligence according to an embodiment of the present invention comprises the steps in which a target discovery system: collects data about one or more diseases to construct a database; extracts, on the basis of the database, one or more candidate targets for discovering a target that is a disease-causing gene or a disease treatment material for a specific disease; and performs an analysis of each of preset factors on the one or more extracted candidate targets to calculate a score for each of the factors. Accordingly, the candidate targets of a disease-causing gene or a disease treatment material are extracted on the basis of structured or unstructured data about the disease-causing gene or the disease treatment material, scores of the candidate targets are calculated for each of the preset factors by using an artificial intelligence model, and a recommended target that is highly likely to be the disease-causing gene or the disease treatment material can be selected. In addition, information about the calculation basis for calculating the score of each of the candidate targets can be provided matched with the respective candidate targets.

IPC Classes  ?

• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G16B 10/00 - ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics

Abstract

The present invention relates to a method for predicting the possibility of immunotherapy for a colorectal cancer patient. Specifically, by using a discriminant of a multiple linear model for determining the applicability of anticancer immunotherapy to obese colorectal cancer patients of the present invention, the patients are classified into two patient groups according to the type of gene mutation, and a patient group with a high immune signature is selected as a group to which immunotherapy can be applied such that it is possible to provide the benefit of providing a new treatment opportunity to obese colorectal cancer patients who have not benefited from the anticancer immunotherapy.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis
• G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 30/10 - Sequence alignmentHomology search
• G16B 30/20 - Sequence assembly
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

Provided are a method for providing information about the diagnosis of a gallbladder polyp and a device for providing information about the diagnosis of a gallbladder polyp using same, the method for providing information about the diagnosis of a gallbladder polyp being implemented by a processor and comprising the steps of: receiving an ultrasound medical image including a gallbladder part of a subject; determining the formation of a gallbladder polyp in the subject by using a first assessment model configured to determine the formation of a gallbladder polyp on the basis of the ultrasound medical image; and when it is determined that the gallbladder polyp is present in the ultrasound medical image, determining a characteristic of the gallbladder polyp on the basis of a second assessment model configured to classify characteristics of the gallbladder polyp.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 7/00 - Image analysis

Abstract

The present invention relates to a novel 4-carbonylamino-4-phenylpyrimidine compound or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a novel 4-carbonylamino-4-phenylpyrimidine compound or a pharmaceutically acceptable salt thereof, which exhibits GDH activity and as such, is effective for prevention or treatment of obesity, diabetes, or fatty liver.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim

Abstract

The present invention provides a digestive organ endoscope system which allows a user to perceive whether or not the tip of an endoscope instrument inserted along a channel approaches the tip of an endoscope channel portion within a certain distance, thereby being capable of quickly inserting the endoscope instrument up to a position close to the tip of the endoscope channel portion, and thus, it is possible to reduce a procedure time and to prevent a digestive organ from being damaged due to instantaneous protrusion of the tip of the endoscope instrument occurring when the endoscope instrument is quickly inserted.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies

Abstract

Provided is a healthcare data providing system using a wearable device. The system according to an embodiment of the present application may comprise: a plurality of detection units (10) provided in a predetermined space (30); a measurement device (20) which includes at least one of an acceleration sensor (21a) and a gyroscope sensor (21b) and generates sensor data corresponding to a movement thereof; and a calculation device (50) which calculates distance data between the plurality of detection units (10) and the measurement device (20), calculates position data of the measurement device (20) in the predetermined space (30) on the basis of the calculated distance data, and calculates healthcare data for any one or more of a plurality of predetermined healthcare areas by using the calculated position data and the sensor data.

IPC Classes  ?

• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G06F 1/16 - Constructional details or arrangements
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/0346 - Pointing devices displaced or positioned by the userAccessories therefor with detection of the device orientation or free movement in a 3D space, e.g. 3D mice, 6-DOF [six degrees of freedom] pointers using gyroscopes, accelerometers or tilt-sensors
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The present invention relates to a method for predicting or diagnosing progressive diabetic nephropathy through the analysis of microRNA contained in urine-derived vesicles and, more particularly, to a method for predicting or diagnosing the risk of developing progressive diabetic nephropathy by analyzing an increase or decrease in the expression level of specific microRNA through microRNA analysis in urine-derived vesicles.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present embodiments relate to a method for providing an optic neuropathy prediction result, and a device for carrying out same, the method comprising the steps of: acquiring a fundus image of a subject; preprocessing the fundus image so that optic neuropathy symptoms in the image more clearly stand out; and determining whether the subject has optic neuropathy by applying the preprocessed image to a pre-modeled optic neuropathy prediction model.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 3/14 - Arrangements specially adapted for eye photography
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/08 - Learning methods

Abstract

The present invention relates to a parathyroid hormone derivative in a dimeric form of a parathyroid hormone fragment and a pharmaceutical composition for the prevention or treatment of bone diseases comprising same. When administered to an animal model, the parathyroid hormone derivative in the dimeric form of the parathyroid hormone according to the present invention significantly increases bone density and enhances osteogenesis and thus can be effectively used for the treatment and prevention of bone diseases.

IPC Classes  ?

• C07K 14/635 - Parathyroid hormone, i.e. parathormoneParathyroid hormone-related peptides
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a pharmaceutical composition comprising a STT compound as an active ingredient for the prevention or treatment of Parkinson's disease. STT showed neuroprotective effect and apoptosis recovery effect in the Parkinson's disease cell model, restored the reduced motility in the MPTP animal model, and was shown to significantly protect dopamine cells, so it can be used for the prevention and treatment of Parkinson's disease.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61P 25/16 - Anti-Parkinson drugs
• A61K 38/46 - Hydrolases (3)
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a data analysis method and system for disease diagnosis aid, and more specifically, to a technique and system capable of providing analysis results through integrated analysis of clinical, MRI images, and genotypic data to aid in disease diagnosis. The method includes receiving medical data of a subject; selecting disease-related data using the medical data; and calculating the disease probability according to the selected disease-related data. The medical data provides a configuration including clinical records, genetic and genetic variants, and MRI.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The present invention relates to a novel 4-carbonylamino-4-phenylpyrimidine compound or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a novel 4-carbonylamino-4-phenylpyrimidine compound or a pharmaceutically acceptable salt thereof, which exhibits GDH activity and as such, is effective for prevention or treatment of obesity, diabetes, or fatty liver.

IPC Classes  ?

• C07D 239/42 - One nitrogen atom
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention relates to a method and a system for analyzing data in order to aid the diagnosis of a disease, and more specifically, to a technique and a system capable of providing analysis results through an integrated analysis of phenotypic, MRI image and genotypic data in order to aid the diagnosis of a disease, the present invention comprising the steps of: receiving medical data of a subject; sorting data related to a disease using the medical data; and calculating the probability of the disease according to the sorted data related to the disease, wherein the medical data includes a phenotypic record, genes and genetic variants and MRI.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

Provided is a device for adjusting the angle of a guide body of a paranasal sinus balloon catheter. A device for adjusting the angle of a guide body of a paranasal sinus balloon catheter according to an embodiment of the present application comprises: a body (110) having a predetermined shape; and at least one space (120, 130, 140) formed in the body (110). The at least one space (120, 130, 140) comprises: an insertion space (121, 131, 141) extending in the vertical direction of the body (110) and formed to have a predetermined depth; and a bending space (122, 132, 142) communicating with the insertion space (121, 131, 141) and extending upward or downward while being inclined at a predetermined angle (α) to the vertical direction. The predetermined angle (α) may correspond to an angle which one of the opening of the maxillary sinus, the opening of the frontal sinus, and the opening of the sphenoidal sinus forms with the nasal cavity.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 29/02 - Inflatable dilatorsDilators made of swellable materials
• A61M 25/10 - Balloon catheters
• A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
• A61M 25/00 - CathetersHollow probes

Abstract

The present invention relates to a composition comprising the UNE-L domain of leucyl-tRNA synthetase as an effective ingredient for increasing muscle. More particularly, the UNE-L domain of LRS according to the present invention, which is a region that controls activity of Vps34, activates mTORC1 involved in protein synthesis and increases myocyte differentiation and muscle fiber regeneration, thus finding useful application in muscle augmentation.

IPC Classes  ?

• A61K 38/53 - Ligases (6)
• A61P 21/06 - Anabolic agents
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to a system and method for correcting a gradient magnetic field error, by a magnetic resonance imaging device on the basis of machine learning. According to a specific example of the present invention, a model about distortion of an image reconstructed with a k-space trajectory derived from a gradient magnetic field is constructed, a k-space trajectory error is predicted on the basis of the result of machine learning using the constructed model, the k-space trajectory is corrected by reflecting the prediction result, and the image is reconstructed with the corrected k-space trajectory, and, thus, additional acquisition of data needed to restore the previously distorted reconstructed image and performing of an image characteristic analysis algorithm can be omitted, thereby increasing accuracy with respect to the corrected k-space trajectory and reducing a cost and calculation complexity caused by adding a monitoring device in terms of hardware.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

Disclosed are a method of measuring concentration distribution of boron for boron neutron capture therapy (BNCT) using magnetic resonance imaging (MRI) alone and a treatment planning method for BNCT. The methods include (a) acquiring an anatomical image of a patient and measuring a boron concentration from magnetic resonance (MR) data, (b) extracting a boron concentration change prediction parameter of the patient and predicting the concentration over time, (c) calculating and verifying a boron distribution prediction value estimated by boron imaging and spectral analysis, and (d) deriving an optimal time for BNCT based on the verified results.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A variable PET apparatus allows structural changes of detector modules in transversal and longitudinal directions to correspond to various imaging purposes and a cross-sectional diameter of a subject while maintaining an arrangement of the detector modules to be close to a true circle. The variable PET apparatus includes: a gantry having an opening on a longitudinal axis; and detector modules supported on the gantry and arranged a predetermined distance apart from each other such that a detection ring is configured with a diameter in a circumferential direction, wherein the gantry is driven by a gantry drive member, and the detector modules are driven by a detector module drive member. According to the present invention, structural changes of the detector modules in the PET apparatus is possible to correspond to a cross-sectional diameter of a subject without additional devices, thereby improving the spatial resolution and sensitivity.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

Disclosed is a multi-axially variable detection module of a PET apparatus, the detection module including: a gantry having a through-hole extending from a side to an opposite side of the gantry; a detection module in which a plurality of detectors for detecting gamma rays emitted from a subject are arranged annularly along an inner circumference of the gantry; and a driving means for moving the plurality of detectors constituting the detection module in a radial direction of the detection module, wherein each of the plurality of detectors is rotatable in a longitudinal direction of the detection module to vary a length thereof in the longitudinal direction, and each of the plurality of detectors include multiple detector elements which are engaged with each other in a hinged manner in a transverse direction (circumferential direction) of the detection module to form a flat or an arc shape.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

The present invention provides a digestive organ endoscope system whereby a user can recognize whether the tip of an endoscope instrument inserted along a channel has come close to the tip of an endoscope channel portion within a predetermined distance and thus can insert the endoscope instrument up to a position close to the tip of the endoscope channel portion at a fast speed, thereby reducing a procedure time and preventing a digestive organ from being damaged by the sudden protrusion of the endoscope instrument resulting from the rapid insertion thereof.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes

Abstract

An ultrasonic cutter for sucking high-temperature spray, comprises: a first blade portion having an ultrasonic transducer for the cutting or joining of human tissue; and a second blade portion formed to abut on one side surface of the first blade portion and having a plurality of suction ports, wherein the second blade portion is capable of sucking the high-temperature spray generated by the ultrasonic transducer through the suction ports.

IPC Classes  ?

• A61B 17/32 - Surgical cutting instruments

Abstract

The present invention relates to a method for screening drug candidates for treating a disease using the interaction between calcium and phosphatidylinositol phosphate. Particularly in the present invention, it was confirmed that the concentration of calcium was increased in the obesity induced insulin resistance animal model and the increased calcium concentration inhibited the migration of Akt protein containing PH domain and the signal transduction, while the protein containing C2 domain was able to migrate to the cell membrane by binding to calcium/PIP complex even under the condition of high calcium concentration. Therefore, the investigation of the interaction between calcium and PIP can be a useful method for screening of drug candidates for treating metabolic disease, cancer or hypertension.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 38/28 - Insulins

Abstract

The present invention relates to a method for acquiring a cardiac image, comprising the steps of: outputting a first frequency by being synchronized with a start time of when a subject, of which a cardiac image is to be acquired, stops breathing for several seconds; acquiring, as first image information, a low frequency component cardiac image for the subject, of which a cardiac image is to be acquired, by being synchronized with an output time of the outputted first frequency; outputting a second frequency by being synchronized with a time of when the subject, of which a cardiac image is to be acquired, starts freely breathing; acquiring, as second image information, a high frequency component cardiac image for the subject, of which a cardiac image is to be acquired, by being synchronized with an output time of the outputted second frequency; and collecting the first image information and the second image information, thereby acquiring a cardiac image of the subject of which a cardiac image is to be acquired. Therefore, an exact cardiac image can be obtained even if a patient, of which a cardiac image is to be acquired, does not stop breathing for a long time.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present invention relates to a composition comprising the UNE-L domain of leucyl-tRNA synthetase as an effective ingredient for increasing muscle. More particularly, the UNE-L domain of LRS according to the present invention, which is a region that interacts with and controls Vps34, activates mTORC1 involved in protein synthesis and increases myocyte differentiation and muscle fiber regeneration, thus finding useful application in muscle augmentation.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A23L 33/18 - PeptidesProtein hydrolysates
• A23L 33/13 - Nucleic acids or derivatives thereof

Abstract

The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient.

IPC Classes  ?

• C07D 265/22 - Oxygen atoms
• C07D 265/14 - 1,3-OxazinesHydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
• A61K 31/537 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
• C07C 317/46 - SulfonesSulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
• C07C 255/57 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C07C 235/38 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• C07C 235/28 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
• C07C 235/16 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention relates to an epiretinal artificial retina device for stimulating the optic nerve in response to visual information of an object captured by an external camera, the device comprising: a substrate disposed on the epiretinal layer of the retina; an optical receiver disposed on the front surface of the substrate so as to receive light emitted from the external camera and transmitted through the eye lens; and a plurality of needle electrodes disposed on the back surface of the substrate, inserted into the cell layer of the retina so as to fix the substrate, and stimulating the bipolar cells in response to an optical signal received by the optical receiver, wherein each of the needle electrodes has a conical shape with a sharp point and a predetermined length, and the sharp point can reach up to the bipolar cell layer of the retina so as to directly stimulate the bipolar cells.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The present invention relates to a method for evaluating radiotherapy planning. The present invention provides a method for evaluating radiotherapy planning, the method comprising the steps of: (a) acquiring a dose distribution of a subject target according to a prescribed radiation dose on the basis of established radiotherapy planning (S100); (b) calculating a dose gradient index (GDI) of three-dimensional isodose levels of the acquired dose distribution, using distances of the isodose level intervals (S200); and (c) plotting a differential dose gradient curve (dDGC), using distance values of the calculated GDIs (S300).

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

The present technology relates to a radio frequency coil for a magnetic resonance imaging device of a multi-RF excitation method. An implementation embodiment of the present technology includes at least two excitation units such that a phase of a current flowing along a conductive wire is rectified, thereby enabling uniform magnetic fields to be obtained in ultra-high magnetic fields.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver

Abstract

Disclosed is a sinus balloon catheter. The sinus balloon catheter includes a body unit, a bending angle adjusting unit that includes a bending angle adjusting lever and a rotary plate, and a guide unit that includes a balloon, and has a pair of bending angle adjusting wires therein. The guide unit includes a first guide body, and a second guide body that is slidably provided in the first guide body, the balloon is provided on the second guide body, the rotary plate is connected to any one of the pair of bending angle adjusting wires to be rotated, and the other bending angle adjusting wire is maintained within the guide unit, and the guide unit is inserted into any one of a sphenoidal sinus, a frontal sinus, and a maxillary sinus.

IPC Classes  ?

• A61M 29/02 - Inflatable dilatorsDilators made of swellable materials
• A61M 25/10 - Balloon catheters
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers

Abstract

The present invention relates to: enzyme-mimetic nanoparticles for allergy diagnosis; a lateral flow chromogenic chip using the enzyme-mimetic nanoparticles for allergy diagnosis, and a manufacturing method therefor; and an immunoplate method and kit for allergy diagnosis, using the enzyme-mimetic nanoparticles for allergy diagnosis. To this end, one aspect of the present invention provides enzyme-mimetic nanoparticles for allergy diagnosis, having a first anti-IgE antibody labeled on the surface thereof by physical bonding, being monodisperse, and comprising an inorganic metal catalyst oxidizing a chromogenic substrate. According to the present invention, provided are a lateral flow chromogenic chip for allergy diagnosis and an immunoplate kit for allergy diagnosis, the chip and the kit: enhancing the stability of a diagnostic kit by using an inorganic metal catalyst-based diagnostic immunoassay method having alleviated enzymatic instability and variability caused by a temperature change and a pH change, which are the problems of a conventional enzyme-based diagnostic immunoassay method; reducing examination time; and improving economic feasibility by reducing costs for each of the processes of manufacturing, transportation, storage, and examination.

IPC Classes  ?

• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
• B01J 23/745 - Iron
• B01J 23/52 - Gold

Abstract

The present invention relates to a magnetic resonance imaging RF coil capable of improving the electromagnetic field sensitivity of a multi-channel RF coil having a structurally decoupled structure. With respect to the multi-channel magnetic resonance imaging RF coil having a structurally decoupled structure due to a partially overlapping arrangement of a plurality of looped single coils (100 and 200), the conductive strips (110 and 210), which define an overlapping region (W) from the partial overlap of the adjacent single coils (100 and 200), are provided with respective slits (111 and 211).

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/34 - Constructional details, e.g. resonators

Abstract

The present invention relates to a multi-axially variable detection module of a PET apparatus, more specifically to a multi-axially variable detection module of a PET apparatus in which the action of reducing the diameter of the detection module is effected by rotating the detector to vary the length of the longitudinal axis of the detection module, wherein the detector comprises a plurality of detector units hinge-coupled in the circumferential direction of the detection module to allow modifying into a flat or arc shape in accordance with imaging environments. To that end, the present invention comprises: a gantry having a through-hole in which both sides are penetrated; a detection module in which a plurality of detectors, which detect gamma rays emitted from an object being inspected, are arranged in a circle around the circumference of the gantry; and a driving apparatus for moving the detectors constituting the detection module in the radial direction thereof, wherein each detector is rotated in the longitudinal axial direction of the detection module to vary the length thereof in the longitudinal axial direction, and each detector comprises a plurality of detector units, and the plurality of detector units are hinge-coupled to each other in the circumferential direction of the detection module to allow varying one surface of the detector into a flat or arc shape.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]

Abstract

The present invention relates to a method for measuring concentration distribution of boron for BNCT using only magnetic resonance imaging (MRI), and a treatment planning method for BNCT, which comprise the steps of: (a) measuring a boron concentration and an anatomical image of a patient from magnetic resonance (MR) data (S10); (b) extracting a boron concentration change prediction parameter of the patient and estimating the concentration for each time period (S20); (c) calculating and verifying a predicted boron distribution value estimated by boron imaging and spectral analysis (S30); and (d) deriving an optimal time for BNCT treatment from the verified result (S40).

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present invention provides a radio frequency coil for magnetic resonance imaging. According to the present invention, the radio frequency coil for magnetic resonance imaging has an adjustable length and comprises: a dipole antenna having a specific resonant frequency according to the length; and electrical switches respectively positioned at both side surfaces of the dipole antenna. According to the present invention, the length of a single radio frequency coil can be randomly adjusted by using the electrical switches and a direct current in an ultra-high magnetic field, and the signals of multiple nuclides, not a single nuclide, can be acquired by using the single radio frequency coil, and thus the single radio frequency coil has multiple resonant frequencies.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver
• G01R 33/34 - Constructional details, e.g. resonators

Abstract

The present invention relates to a magnetic resonance spectroscopic signal pre-processing apparatus, which acquires processed data by pre-processing a magnetic resonance spectroscopic signal in order to extract substance information in the human body from the processed data produced by pre-processing the magnetic resonance spectroscopic signal acquired for the human body, comprises: a Fourier transform unit for Fourier transforming the magnetic resonance spectroscopic signal acquired for the human body from a time domain data into a frequency domain data; a differential filter application unit for applying a differential filter to the Fourier transformed magnetic resonance spectroscopic signal of the frequency domain so as to remove a signal, which is not the substance information in the human body to be analyzed; and an abs application unit for applying an absolute value function to the signal to which the differential filter is applied, thereby pre-processing the magnetic resonance spectroscopic signal acquired for the human body. Therefore, data of a metabolite to be analyzed, which is to be acquired from a magnetic spectroscopic signal, can be easily acquired or removed, baseline distortion from a water signal or a fat signal can be corrected, accurate data detection is facilitated since there is no signal distortion because of an absolute value form regardless of a phase value, and accuracy of metabolite quantitative analysis on an acquired signal can be improved since a signal-to-noise ratio is improved.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 23/16 - Spectrum analysisFourier analysis

Abstract

The present invention relates to a magnetic resonance imaging apparatus for an angiography, having an RF coil, applying an RF pulse through the RF coil to an object, and generating blood vessel data by receiving an MR signal from the object through the RF coil, the magnetic resonance imaging apparatus comprising: a signal transmission and reception unit including an RF transmission and reception unit including a signal transmission unit for applying the RF pulse to the RF coil and a signal reception unit for receiving, from the RF coil, the MR signal containing characteristics of a TOF signal and a bSSFP signal, and a gradient magnetic field amplifier for controlling a spatial encoding gradient magnetic field; and a control unit including an RF control unit for generating the RF pulse so as to acquire the TOF signal and the bSSFP signal and transferring the generated RF pulse to the signal transmission unit of the RF transmission and reception unit, and a gradient magnetic field control unit for generating the gradient magnetic field control signal and transferring the generated gradient magnetic field control signal to the gradient magnetic field amplifier. As a result, the RF pulse, which simultaneously includes a TOF and a bSSFP, is applied to a blood vessel and a blood stream such that a blood vessel image can be accurately acquired by receiving a blood vessel image signal having a high intensity, even if the blood stream is slow, thereby reducing a time for acquiring the blood vessel image from the magnetic resonance imaging apparatus.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/026 - Measuring blood flow
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography

Abstract

The present technology relates to a method for reconstructing three-dimensional magnetic resonance spectroscopic imaging on the basis of multi-channel coil parallel imaging. According to an embodiment of the present technology, three-dimensional resonance spectroscopic imaging can be acquired in a short time since fewer signals are acquired for all three directions of a three-dimensional space to be phase-encoded.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/48 - NMR imaging systems
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

The aim of the present invention is to provide a magnetic resonance imaging RF coil capable of improving RF transmission efficiency without reducing signal sensitivity by substituting a RF shield which is conventionally arranged external to the RF coil, and to that end, the present invention comprises: a looped transmission and reception coil (110) connected to a cable for RF transmission and reception, and provided with a first inductor (111); and a looped power transmission coil (120) provided with a second inductor (121) adjacent to the first inductor (111), and arranged on a different plane distanced from the transmission and reception coil (110).

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/34 - Constructional details, e.g. resonators
• G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers

Abstract

The present invention relates to a variable PET apparatus (10) allowing structural changes of a detection module in longitudinal and latitudinal directions to correspond to various imaging goals and cross-sectional diameter of objects to be inspected while maintaining an arrangement that is close to a true circle, the variable PET apparatus (10) comprising: a gantry (110, 120) having an opening on the longitudinal axis; and detection modules (210) supported on the gantry (110, 120), and arranged a set distance apart from each other to form a detection ring in the circumferential direction of any diameter, wherein the gantry (110, 120) is driven by a gantry driving member, and the detection modules (210) are driven by a detection module driving member. According to the present invention, by allowing structural changes of the detection modules (210) in the PET apparatus to correspond to the cross-sectional diameter of objects to be inspected without having to be equipped with separate equipment, high spatial resolution and sensitivity can be provided, and further, the benefit of reduction in expenses can be had.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]

Abstract

The present invention provides an apparatus and a method of compensating for signal distortion of a magnetic resonance spectroscopic imaging (MRSI) or a magnetic resonance spectroscopy (MRS). According to the present invention, the method for compensating for magnetic resonance spectroscopic signal distortion comprises: a first reference signal measuring step of acquiring an additional reference signal immediately after a water signal suppression RF signal is acquired; a second reference signal measuring step of acquiring an additional reference signal immediately after a first excitation RF signal is acquired; and a step of compensating for distortion of a final data signal by using the reference signal immediately after the water signal suppression RF signal is acquired and the reference signal immediately after the first excitation RF signal is acquired. The present invention can compensate for the distortion of the final signal without an additional acquisition time for a reference water signal when MRS or MRSI data is acquired.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities

Abstract

Provided is a laryngoscope capable of preventing tooth damage. The laryngoscope capable of preventing tooth damage according to an embodiment of the present invention may comprise: a blade (100) including a first end (110) to be inserted into the airway; and a handle (200) mounted to the lower end of the blade (100), wherein a groove is formed on at least one of the upper surface (120) and the lower surface (130) of the blade (100).

IPC Classes  ?

• A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
• A61B 1/32 - Devices for opening or enlarging the visual field, e.g. of a tube of the body

Abstract

The present invention relates to a pharmaceutical composition for treating corneal injury containing 8-oxo-deoxyguanosine (8-oxo-2'-deoxyguanosine) or a pharmaceutically acceptable salt thereof as an active ingredient. Specifically, by confirming that a corneal epithelium was restored (regenerated) quicker and the clarity of a cornea improved when it was administered to a mouse model of corneal injury induced by ethanol, 8-oxo-deoxyguanosine (8 -oxo-2'-deoxyguanosine) of the present invention may be useful for the treatment of corneal injury.

IPC Classes  ?

• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• C11D 3/28 - Heterocyclic compounds containing nitrogen in the ring
• C11D 11/00 - Special methods for preparing compositions containing mixtures of detergents

Abstract

The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient, and it has been confirmed that the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof may excellently suppress 'microglial activation' and shows excellent inhibition activity against acetylcholinesterase, JNK1, JNK2 and JNK3, and in addition to this, significant enzyme inhibition activity has been confirmed in a neurological diseases-related enzyme group, RIPK5, CDK3/cyclin E, PKN2/PRK2, Haspin, STK25/YSK1, ARK5/NUAK1, PKCb2, CDK2/cyclin O, DAPK1, PKCa, CDK1/cyclin B, MST3/STK24 and TLK1 and it has been confirmed that cell death suppression effect may be exhibited, and thus the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be usefully used for a pharmaceutical composition for preventing or treating neurological disorders or health functional food composition for preventing or improving neurological disorders by being contained therein as an active ingredient.

IPC Classes  ?

• C07D 265/14 - 1,3-OxazinesHydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
• A61K 31/537 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a functional condom that enables a patient with erectile dysfunction to have normal sexual intercourse and, more particularly, to a condom including a micro-needle (13) provided on an inner surface of an upper portion (10), wherein the micro-needle (13) contains a drug (P) that is an erection-inducing substance. According to the present invention, patients, including those for whom pharmacotherapy is not possible due to side effects or due to a lack of therapeutic effect, may resolve erectile dysfunction without the use of painful injection therapy, by simply wearing the condom.

IPC Classes  ?

• A61F 6/04 - Condoms, sheaths or the like
• A61F 5/41 - Devices for promoting penis erection
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Provided are a sensing device for positioning an affected part and a method therefor. A sensing device according to an embodiment of the present invention comprises: a clip attached to an affected part through an endoscope tool, the clip comprising an electronic marker (110); and a probe comprising a measuring portion capable of recognizing the electronic marker, the probe approaching outside the affected part.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to: a pharmaceutical composition, for preventing or treating hepatic fibrosis or cirrhosis, comprising 8-OHdG or pharmaceutically acceptable salts of same; a method for preventing or treating hepatic fibrosis or cirrhosis by means of the pharmaceutical composition; and a food composition, for remedying hepatic fibrosis or cirrhosis, comprising 8-OHdG or pharmaceutically acceptable salts of same. By means of the pharmaceutical composition for preventing or treating hepatic fibrosis or cirrhosis of the present invention, the level of various markers having increased expression levels due to induced hepatic fibrosis can be decreased and thus the pharmaceutical composition can widely be utilized for effective prevention or treatment of hepatic fibrosis or cirrhosis induced by the hepatic fibrosis.

IPC Classes  ?

• A61K 31/708 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

A magnetic resonance imaging system is disclosed. The disclosed magnetic resonance imaging system comprises a system control unit capable of independently acquiring magnetic resonance imaging signals of different elements existing in a body to be examined. The system control unit comprises: a first system control unit capable of acquiring a magnetic resonance signal of a first element; and a second system control unit capable of acquiring a magnetic resonance signal of a second element different from the first element. The first and second system control units have physically independent configurations. The first and second system control units independently control first and second RF coil elements of an RF coil, respectively.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/385 - Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using gradient magnetic field coils
• G01R 33/421 - Screening of main or gradient magnetic field

Abstract

Disclosed is a three-dimensional parallel image reconstruction scheme and system using a boomerang-shaped kernel. A three-dimensional parallel image reconstruction scheme according to an embodiment of the present invention comprises the steps of: (a) acquiring MRI scanning data including a plurality of missing data and a plurality of acquired data for a subject; (b) filling the plurality of missing data with estimation data values calculated on the basis of the plurality of acquired data on a k-space; and (c) reconstructing the MRI scanning data on the k-space, which is filled with the estimation data values, as an MRI image, wherein step (b) is performed using a boomerang-shaped kernel.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration

Abstract

The present invention relates to an endoscope device having a plurality of coupling parts provided on a first endoscope tube such that a second endoscope tube can be mounted thereon and used, and provides an endoscope device comprising: a first endoscope tube having an optical fiber channel and a lens channel; a second endoscope tube detachably coupled to the first endoscope tube; and a plurality of coupling parts provided on the second endoscope tube so as to enable the first endoscope tube to be mounted thereon. Therefore, different types of endoscope devices can be selectively coupled according to the needs of a user and used simultaneously, such that the operation, which generally cannot be performed only with one endoscope device, is enabled.

IPC Classes  ?

• A61B 1/012 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor
• A61B 1/005 - Flexible endoscopes

Abstract

The present invention relates to an endoscopic instrument and a system comprising the same, the endoscopic instrument having a sensor unit and a measurement unit in a working means to be used while being inserted and connected to a forceps hole of an endoscope so as to make a more accurate procedure possible. The endoscopic instrument comprises: a tube in which a forceps hole is formed; an endoscopic working means inserted into the forceps hole and positioned at the front end of the tube; and an operation unit formed on the end of the tube, wherein the sensor unit and the measurement unit are formed on the endoscopic working means, and information obtained from the sensor unit and the measurement unit is outputted by means of a display means. As such, it is possible to more easily graph the length and the physical characteristics of a procedure site in an endoscopic procedure, thereby enabling an accurate and efficient procedure.

IPC Classes  ?

• A61B 1/012 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor
• A61B 1/045 - Control thereof
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements

Abstract

The present invention relates to a nasal cavity washer assembly comprising a saline solution preparation unit and aims to provide a nasal cavity washer assembly comprising: a water storage unit (100) which stores water; a salt storage unit (200) which stores a salt; a saline solution storage unit (300) which stores a saline solution produced by adding the water of the water storage unit (100) and the salt of the salt storage unit (200); and treatment units (350, 360) which are respectively connected to the saline solution storage unit (300), wherein the treatment units (350, 360) each comprise an injection unit (350) and a suction unit (360).

IPC Classes  ?

• A47K 7/00 - Body washing or cleaning implements
• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61H 35/04 - Baths for specific parts of the body, e.g. breast douches for the nose
• A47K 7/04 - Washing or cleaning devices, hand or mechanically operated

Abstract

The present invention relates to a method for detecting apoptosis using a phosphatidylinositol phosphate-binding material, a method for screening anticancer agents, a method for screening apoptosis-inhibiting materials, and a method for inhibiting phagocytosis.

IPC Classes  ?

• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to a segmented coil unit and a coil assembly comprising the same. As a segmented coil unit which is used to form in a prefabricated manner a coil assembly for magnetic resonance imaging composed of closed loop coils of plural channels, a segmented coil unit comprising: a first coil part constituting a part of the closed loop coil of a first channel; and a second coil part constituting a part of the closed loop coil of a second channel arranged adjacent to the first channel and composed of an equivalent circuit with the first coil part is provided whereby there is an advantage that it is possible to obtain a more accurate image since the configuration of a coil can be modified to correspond to various surface shapes. Further, since the segmented coil unit and the coil assembly comprising the same are provided, only a segmented coil unit which requires replacement can be replaced, and thus there is the advantage of easy maintenance.

IPC Classes  ?

• G01R 33/34 - Constructional details, e.g. resonators
• G01R 33/3415 - Constructional details, e.g. resonators comprising surface coils comprising arrays of sub-coils
• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present invention relates to a method for producing a [11C] radiopharmaceutical product and, particularly, discloses a method for producing a radiopharmaceutical product, the method comprising a step for performing the [11C] methylation of a phenol-based precursor under the presence of a naphthalene-based organic base. The production method of the present invention, when producing a radiopharmaceutical product from a phenol-based precursor by means of [11C] methylation, uses a proton sponge, for example, a naphthalene-based organic base as a catalyst in order to promote an alcohol methylation reaction as well as improve the solubility of the precursor, and may thus produce a radiopharmaceutical product at a stable and high yield.

IPC Classes  ?

• C07C 211/00 - Compounds containing amino groups bound to a carbon skeleton
• A61K 51/04 - Organic compounds

Abstract

Disclosed are a method and a system for acquiring an additional image, for identifying perfusion, by using a contrast-enhanced MRA image. According to one embodiment of the present invention, the method comprises the steps of: (S10) acquiring an MRA image, which comprises a plurality of image frames, for an object by using MRI equipment; (S20) determining at least one target image frame among the image frames; (S30) determining at least one reference image frame, which corresponds to the at least one target image frame, among the image frames; (S40) calculating at least one piece of subtracted data by subtracting the data of the corresponding reference image frame from the data of each target image frame; and (S50) acquiring at least one cross-sectional image for an area-of-interest of the object on the basis of each piece of the subtracted data.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences

Abstract

The present invention relates to a radioactive compound to which [18F]alkyl is introduced as a tracer for PET for diagnosing brain neural inflammation, and to a method for producing said radioactive compound.

IPC Classes  ?

• A61K 51/04 - Organic compounds

Abstract

The present inventions relates to a method for producing a radioactive compound containing [18F] and, particularly, discloses discloses a method for producing a radioactive compound containing [18F], the method comprising: i) a step for making a [18F]fluoroalkyl compound into triflate by making the [18F]fluoroalkyl compound react with AgOTf; and ii) a step for making the compound made into triflate react with a radioactive compound precursor including NH, OH, or SH.

IPC Classes  ?

• A61K 51/04 - Organic compounds

Abstract

The present invention relates to a device and a system for monitoring a user's urination on the basis of the user's posture or change in posture, a method for monitoring the user's urination, and a computer-readable recording medium in which a computer program for executing the method is recorded. According to one aspect of the present invention, provided is the method comprising the steps of: deriving information on a user's posture or change in posture on the basis of motion data of a user device, wherein the motion data is recorded according to the passage of time by a sensor included in the user device; and determining whether the user has urinated on the basis of the derived information.

IPC Classes  ?

• A61B 5/20 - Measuring urological functions
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A functional magnetic resonance imaging (FMRI) method and an FMRI system are disclosed. The FMRI method according to one embodiment of the present invention comprises the steps of: (a) obtaining multi-echo echo planar imaging (ME-EPI) data on an area of interest of an object; (b) calculating a standard deviation for a pure signal component, from which a noise component is excluded, for at least two pieces of echo time (TE) data among a plurality of pieces of TE data of the ME-EPI data; (c) estimating T2* deviation information of the ME-EPI data on the basis of the calculated standard deviations; and (d) displaying a functional image for the area of interest of the object by displaying strength in proportion to the estimated T2* deviation information.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences

Abstract

Disclosed is a method for suppressing a water signal and reinforcing a metabolite signal by adjusting a central frequency and reception bandwidth of an excitation signal band in a magnetic resonance spectroscopy (MRS) image technique. According to one embodiment of the method for suppressing the water signal and reinforcing the metabolite signal, an excitation signal adjusted so as to have the central frequency, which is smaller than the resonant frequency of the water, is applied, and the size of the reception bandwidth is applied so as to be the same as a difference between the resonant frequency of the water and the central frequency.

IPC Classes  ?

• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver
• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences
• G01R 33/48 - NMR imaging systems

Abstract

In order to improve the stability, dispersibility, and bioavailability of curcumin, the present invention relates to a lipid nanoparticle comprising ginsenosides and phospholipids; a method for preparing the lipid nanoparticle; a pharmaceutical composition for preventing or treating cancer comprising the lipid nanoparticle; an anti-oxidant food composition, a feed composition, and a cosmetic composition. As the curcumin-containing lipid nanoparticle provided by the present invention improves the stability, dispersibility, and bioavailability by using ginsenosides, the curcumin-containing lipid nanoparticle can be widely used in the development of various curcumin-containing products.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/55 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing phosphorus
• A61Q 19/00 - Preparations for care of the skin
• A23K 20/00 - Accessory food factors for animal feeding-stuffs

Abstract

Disclosed is an artificial valved conduit that is a composite valved graft comprising double sewing cuffs, which can be easily used in aortic root replacement. The composite valved graft comprises a valve and a conduit part connected to the valve. The conduit part comprises a sewing cuff positioned on the outer circumference thereof. The sewing cuff comprises a first sewing cuff and a second sewing cuff positioned below the first sewing cuff. Accordingly, a double suture is easily performed, so that it is possible to prevent the loss of blood after a surgery and to reduce surgical time at the same time.

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
• A61F 2/06 - Blood vessels
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

According to the present invention, accurate T2* and vascular images are concurrently acquired by acquiring a T2* image without a flow compensation and a T2* image with a flow compensation and subtracting the two images to reconstitute an image showing the flow phenomenon. Furthermore, an accurate T2* image can be acquired by using the readout gradient without the flow compensation and also the accurate T2* and vascular images can be concurrently acquired. The clinical judgment for blood flow rate of the blood vessel and the clinical judgment for acute stroke can be concurrently made, and so the present invention can be widely utilized in clinical practice.

IPC Classes  ?

• A61B 5/026 - Measuring blood flow
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction

Abstract

본 발명은 HMG-CoA 환원효소 억제제를 포함하는 비스테로이드성 소염제(non-steroidal anti-inflammatory drugs; NSAIDs)에 의하여 유발된 소장 궤양의 예방 또는 치료용 약학 조성물에 관한 것으로, 보다 구체적으로 본 발명은 스타틴(statin) 또는 이의 약학적으로 허용가능한 염을 포함하는 비스테로이드성 소염제에 의하여 유발된 소장 궤양의 예방 또는 치료용 약학 조성물, 및 상기 조성물을 개체에 투여하는 단계를 포함하는 비스테로이드성 소염제에 의하여 유발된 소장 궤양의 예방 또는 치료방법에 관한 것이다. 본 발명의 HMG-CoA 환원효소 억제제는 염증 관련 유전자의 발현 감소 및 염증 관련 신호전달을 저해함으로써 염증을 완화시킬 수 있고, ROS의 생성을 억제하여 산화스트레스를 감소시키므로, 비스테로이드 소염제에 의하여 유발된 소장 궤양의 예방 또는 치료에 효과적으로 활용될 수 있을 것이다.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim

Abstract

Images where the vascular walls are automatically divided are obtained by obtaining two MRI images that reflect different properties of the blood vessel and obtaining the difference between the two images. This can image both the vascular inner and the outer walls, thereby obtaining the exact size of the blood vessel, and the thickness between the vascular inner and outer walls. Therefore, it is possible to stably perform the operation using a stent with an accurate size during the stent procedure.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 5/026 - Measuring blood flow
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction

Abstract

A curved movable beam-stop array which has a generator, a curved grid and a controller. The generator generates radiation beams while rotating to a gantry angle. The curved grid is positioned in the radiation direction of the radiation beams generated from the generator. The controller controls operations of the grid. A plurality of slits of the grid are spaced apart from each other at a predetermined distance and allow at least a portion of the radiation beams generated from the generator to pass through. The controller moves the slit by a predetermined distance when the generator moves by a predefined angle.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• A61B 6/04 - Positioning of patientsTiltable beds or the like
• G21K 1/02 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators
• G21K 1/04 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators using variable diaphragms, shutters, choppers
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/14 - Applications or adaptations for dentistry
• A61B 6/06 - Diaphragms

Abstract

The present invention relates to a multi-channel RF coil array for a magnetic resonance imaging device and, more particularly, to a multi-channel transmission-dedicated RF coil using multiple circular polarized (CP) modes in a super-high-frequency magnetic resonance imaging device. The present invention provides a multi-channel RF coil array for a magnetic resonance imaging device comprising as many as L coil elements that surround the subject circularly, wherein the L coil elements are classified into a plurality of coil groups comprising a plurality of coil elements, a plurality of current phase values, which increase by an integer multiple of 360°/L, are applied to the plurality of coil elements belonging to each coil group, and the plurality of current phase values, which are applied to each coil group, are applied independently of a plurality of current phase values applied to a different coil group. The present invention is advantageous in that a plurality of current phase values, which are applied to each of the first coil group and the second coil group, can be applied independently of each other, making it possible to form a uniform magnetic field.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals

Abstract

본 발명은 웨어러블 디바이스를 이용한 수면효율 연산 방법 및 수면 조절 방법에 관한 것으로서, 평균 침대시간(TB)을 연산하고, 평균 실제수면시간(TS)을 연산하고, 이에 따라 평균 수면효율(ES)을 연산하여 수면효율저하를 판별하고 제안 침대시간(TBp)을 제공함으로써, 내원을 하지 않으면서도 정확하고 적시적인 치료가 가능하며, EMR 서버와 연계되어 모든 정보가 자동화되어 기록되고 관리할 수 있어서 불면증 환자의 수면습관관리와 인지 행동 치료에 도움을 준다.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate

Abstract

The present invention provides a UI/UX output method customized for the elderly, the method outputting a UI/UX that is easily recognizable to the elderly who have insufficient physical and recognition ability, and outputting a normal UI/UX to the elderly who are normal and do not have insufficient physical and recognition ability and who have a high level of IT proficiency. To this end, physical and recognition abilities are measured, whether there is a slight recognition disability is determined and categorizing into levels is implemented, and on this basis, contents are configured and a UI/UX is output according to a pre-stored UI/UX settings.

IPC Classes  ?

• H04M 1/247 - Telephone sets including user guidance or feature selection means facilitating their use
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]

Abstract

The present invention relates to a penis erection assisting device which enables, by means of a simple action of opening a supply switch before having sexual intercourse, an expansion liquid to be supplied to an expansion-type intra-penis substitute by pressure of abdominal walls according to movement of a woman during the sexual intercourse, so that during a natural course of sexual intercourse, injection and discharge of saline solution for the operation of the expansion-type intra-penis substitute can be performed secretly without the partner being able to recognize the injection and discharge.

IPC Classes  ?

• A61F 5/41 - Devices for promoting penis erection
• A61F 2/26 - Penis implants

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating pulmonary fibrosis comprising an isothiocyanate-based compound and a biguanide agent as active ingredients, a method for preventing or treating pulmonary fibrosis using the composition, and use of the isothiocyanate-based compound and the biguanide agent for the preparation of the prophylactic or therapeutic agent for preventing or treating pulmonary fibrosis. The pharmaceutical composition comprising the isothiocyanate-based compound and the biguanide agent as active ingredients of the present invention can be used to stably prevent or treat pulmonary fibrosis for which specific therapeutic agents have not yet been known, and thus it can be widely used for health and welfare improvement through treatment of pulmonary fibrosis.

IPC Classes  ?

• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)

Abstract

The present invention relates to a method for detecting apoptosis using a material binding to phosphatidylinositol phosphate, a method for screening an anti-drug, a method for screening an apoptosis inhibitory material, and a method for inhibiting phagocytosis.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to a balloon-mounted stent having a balloon formed at the front end of a stent, and capable of widening a stenosis region by the insertion of a metal stent into an accurate stenosis region. Provided is a balloon-mounted stent insertion device comprising: an inner tube; a balloon connected to the outside of the inner tube, and a stent located at one side of the balloon and provided on the outside of the inner tube, and serving as a stopper protrusion of the stent when the balloon expands. Therefore, the location of a stent in a stenosis region can be more accurately and easily identified during a stent insertion operation.

IPC Classes  ?

• A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
• A61M 25/098 - Arrangements for enabling the detection of the internal position of the catheter, e.g. radiographically using radio-opaque markers