Disclosed are apparatuses, systems, and methods for processing materials, including biological or chemical materials. A manufacturing module may include a work station configured to perform a process involving equipment capable of use with biological or chemical material, a first transportation segment that is configured to connect and disconnect with a second transportation segment such that when connected, a carrier of the biological or chemical material can be transported from the first transportation segment to the second transportation segment, a pick and place robot configured to move an element between the first transportation segment and the work station; and a movement mechanism configured to allow the work station, the first transportation segment, and the pick and place robot to be moved as a single unit. A system may include a plurality of manufacturing modules that are reconfigurable to a plurality of configurations.
Aspects of the disclosure relate to aromatic amino acid ammonia lyases (ALs), phenylalanine ammonia lyases (PALs), and tyrosine ammonia lyase (TALs), including engineered enzymes, and their use in catalyzing chemical reactions.
The present disclosure provides chimeric antigen receptors comprising novel intracellular domain pairs. It further provides cells expressing such chimeric antigen receptors, compositions of cells expressing such chimeric antigen receptors, as well as methods of making and using the same.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
5.
NOVEL INTRON SEQUENCES FOR CIRCULARIZING RNA MOLECULES
In certain aspects, the present disclosure provides nucleic acid molecules containing an intron pair for production of linear and/or circularized nucleic acid molecules, as well as methods of preparation and methods of use.
Aspects of the disclosure relate to tyrosine hydroxylases, including engineered enzymes, and their use in catalyzing chemical reactions to produce betalain. Additional aspects of the disclosure relate to genetic modifications of host cells to improve betalain production.
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
C12P 17/16 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing two or more hetero rings
C12P 19/60 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Described are host cells comprising heterologous polynucleotides encoding polyketide synthase (PKS) variants that are capable of producing more divarinol in the presence of butyrate.
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptide sequences having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the pesticidal polypeptides, DNA constructs comprising the nucleic acid molecules, vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the pesticidal polypeptides. Nucleotide sequences encoding the polypeptides provided herein can be used in DNA constructs or expression cassettes for transformation and expression in organisms of interest. The compositions and methods provided herein are useful for the production of organisms with enhanced pest resistance or tolerance. Transgenic plants and seeds comprising a nucleotide sequence that encodes a pesticidal protein of the invention are also provided. Methods are provided for producing the polypeptides disclosed herein, and for using those polypeptides for controlling a pest. Methods and kits for detecting polypeptides of the invention in a sample are also included.
C07K 14/37 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
10.
COMPOSITIONS AND METHODS FOR CONTROLLING PLANT PESTS AND IMPROVING PLANT HEALTH
Compositions and methods for controlling plant pests and/or improving at least one agronomic trait of interest in a plant are provided. Such compositions and methods comprise a bacterial strain that can be used as an inoculant for plants. Therefore, methods for growing a plant susceptible to a plant pest and/or plant disease caused by a plant pest and methods for controlling plant pests and/or plant disease on a plant susceptible to the plant pest and/or plant disease are also provided.
The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in genes, such as PKP2, associated with arrhythmogenic cardiomyopathy. Also, provided herein are methods for treating and/or delaying the onset of arrhythmogenic cardiomyopathy.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The present disclosure provides, among other things, methods and compositions useful in the engineering of chimeric switch receptors (CSRs) and/or natural killer (NK) cells. The present disclosure provides, among other things, sequences for use in stimulatory domains, such as CSR stimulatory domains that are engineered to promote expansion, persistence, and/or function of NK cells, especially under immunosuppressive conditions. The present disclosure further provides combinations of sequences for use in stimulatory domains, such as CSR stimulatory domains that are engineered to promote expansion, persistence, and/or function of NK cells, especially under immunosuppressive conditions.
The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Downloadable electronic publications in the nature of
reports, white papers, and articles in the fields of
viruses, pathogens, pharmaceutical and drug contaminants,
diagnostic testing, pandemic response, biosecurity,
biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable publications in the nature
of reports, white papers, and articles in the fields of
viruses, pathogens, pharmaceutical and drug contaminants,
diagnostic testing, pandemic response, biosecurity,
biosurveillance, bioinformatics, and biointelligence. Monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs for viruses, pathogens, and
pharmaceutical and drug contaminants; detection of viruses,
pathogens, and pharmaceutical and drug contaminants in
water, air, soil, surfaces, and human and animal reservoirs;
scientific and technological services, namely, bio-sample
testing services for others in the fields of biosecurity,
biosurveillance, bioinformatics, biointelligence, scientific
research, and scientific diagnostics; scientific and
technological services, namely, biosecurity surveillance for
analyzing food, water, air, and environmental resource
safety; consulting services for others in the field of
design, planning, and implementation project management of
biosecurity initiatives related to the monitoring, testing,
and detection of viruses, pathogens, and pharmaceutical and
drug contaminants in water, air, soil, surfaces, and human
and animal reservoirs; scientific laboratory services;
scientific and technological research and development in the
fields of biosecurity, biosurveillance, bioinformatics, and
biointelligence; providing scientific and technological
information in the fields of biosecurity, biosurveillance,
bioinformatics, and biointelligence; scientific and
technological services, namely, analysis, and reporting in
the fields of viruses, pathogens, pharmaceutical and drug
contaminants, diagnostic testing, pandemic response,
biosecurity, biosurveillance, bioinformatics, and
biointelligence; providing online non-downloadable software
for viewing reports and delivering, accessing, sharing,
analyzing, and visualizing data in the fields of viruses,
pathogens, pharmaceutical and drug contaminants, diagnostic
testing, pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; providing medical
information in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; all of the foregoing
services based on information collected from bio-sample
monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs. Surveillance services, namely, surveillance of premises for
viruses, pathogens, and pharmaceutical and drug
contaminants.
C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
C12P 33/20 - Preparation of steroids containing heterocyclic rings
The present disclosure provides, among other things, methods and compositions useful in the engineering of chimeric antigen receptors (CARs) and/or T cells. The present disclosure provides, among other things, sequences for use in stimulatory domains, such as CAR stimulatory domains that are engineered to promote expansion, persistence, and/or function of T cells. The present disclosure further provides combinations of sequences for use in stimulatory domains, such as CAR stimulatory domains that are engineered to promote expansion, persistence, and/or function of T cells.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable electronic publications in the nature of
reports, white papers, and articles in the fields of
viruses, pathogens, pharmaceutical and drug contaminants,
diagnostic testing, pandemic response, biosecurity,
biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable publications in the nature
of reports, white papers, and articles in the fields of
viruses, pathogens, pharmaceutical and drug contaminants,
diagnostic testing, pandemic response, biosecurity,
biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable software for viewing
reports and delivering, accessing, sharing, analyzing, and
visualizing data in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; scientific and
technological services, namely, analysis, and reporting in
the fields of viruses, pathogens, pharmaceutical and drug
contaminants, diagnostic testing, pandemic response,
biosecurity, biosurveillance, bioinformatics, and
biointelligence; providing scientific and technological
information in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; providing medical
information in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; all of the foregoing
services based on information collected from bio-sample
monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs for viruses, pathogens, and
pharmaceutical and drug contaminants; detection of viruses,
pathogens, and pharmaceutical and drug contaminants in
water, air, soil, surfaces, and human and animal reservoirs;
scientific and technological services, namely, bio-sample
testing services for others in the fields of biosecurity,
biosurveillance, bioinformatics, biointelligence, scientific
research, and scientific diagnostics; scientific and
technological services, namely, biosecurity surveillance for
analyzing food, water, air, and environmental resource
safety; consulting services for others in the field of
design, planning, and implementation project management of
biosecurity initiatives related to the monitoring, testing,
and detection of viruses, pathogens, and pharmaceutical and
drug contaminants in water, air, soil, surfaces, and human
and animal reservoirs; scientific laboratory services;
scientific and technological research and development in the
fields of biosecurity, biosurveillance, bioinformatics, and
biointelligence; providing scientific and technological
information in the fields of biosecurity, biosurveillance,
bioinformatics, and biointelligence; scientific and
technological services, namely, data analysis in the fields
of biosecurity, biosurveillance, bioinformatics, and
biointelligence. Medical consulting in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; providing medical
information in the fields of viruses, pathogens,
pharmaceutical and drug contaminants, diagnostic testing,
pandemic response, biosecurity, biosurveillance,
bioinformatics, and biointelligence; all of the foregoing
services based on information collected from bio-sample
monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs. Surveillance services, namely, surveillance of premises for
viruses, pathogens, and pharmaceutical and drug
contaminants.
A fluid sampling device includes a port adapter configured to be coupled to a fluid conduit external to the fluid sampling device. The port adapter includes a housing that defines a first fluid conduit with an inlet and an outlet and a sidewall extending therebetween. A second fluid conduit extends through the sidewall of the housing into the first fluid conduit and is in fluid communication therewith. A collection adapter is detachably coupled to the port adapter via the second fluid conduit and a hose is coupled to the collection adapter and extends through the second fluid conduit into the first fluid conduit.
Aspects of the disclosure relate to phenylalanine ammonia lyase (PAL) enzymes, including engineered PAL enzymes, and their use in catalyzing chemical reactions.
Aspects of the disclosure relate to phenylalanine ammonia lyase (PAL) enzymes, including engineered PAL enzymes, and their use in catalyzing chemical reactions.
Aspects of the disclosure relate to use of prenyltransferases for the production of prenylated stilbenes in recombinant cells or in vitro. Further aspects of the disclosure relate to use of prenyltransferases for the production of prenylated acridines in recombinant cells or in vitro.
C12P 7/22 - Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
C12M 1/40 - Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
In certain aspects, the present disclosure provides nucleic acid molecules containing an internal ribosomal entry site and/or two introns for production of linear and/or circularized nucleic acid molecules, as well as methods of preparation and methods of use.
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase
C12N 15/52 - Genes encoding for enzymes or proenzymes
C12N 15/62 - DNA sequences coding for fusion proteins
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C12P 19/56 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Aspects of the disclosure relate to penicillin G acylase (PGA) enzymes, including engineered PGA enzymes, and their use in catalyzing chemical reactions related to biosynthesis of beta-lactam antibiotics.
C12P 35/04 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
C12P 37/04 - Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
(1) Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and pharmaceutical and drug contaminants; detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, biosurveillance, bioinformatics, biointelligence, scientific research, and scientific diagnostics; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory services; scientific and technological research and development in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data analysis in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence.
(2) Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs.
(3) Surveillance services, namely, surveillance of premises for viruses, pathogens, and pharmaceutical and drug contaminants.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Downloadable electronic publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. (1) Providing online non-downloadable publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence.
(2) Providing online non-downloadable software for viewing reports and delivering, accessing, sharing, analyzing, and visualizing data in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, analysis, and reporting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence.
(3) Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs.
The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in genes, such as UBE3A, associated with Angelman syndrome. Also, provided herein are methods for treating and/or delaying the onset of Angelman syndrome.
The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in genes, such as UBE3A, associated with Angelman syndrome. Also, provided herein are methods for treating and/or delaying the onset of Angelman syndrome.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
The present disclosure provides, among other things, methods and compositions useful in the engineering of chimeric antigen receptors (CARs) and/or natural killer (NK) cells. The present disclosure provides, among other things, sequences for use in stimulatory domains, such as CAR stimulatory domains that are engineered to promote expansion, persistence, and/or function of NK cells. The present disclosure further provides combinations of sequences for use in stimulatory domains, such as CAR stimulatory domains that are engineered to promote expansion, persistence, and/or function of NK cells.
Compositions and methods for controlling a plant pest or for treating or preventing plant disease are provided. Such compositions and methods comprise a bacterial strain that controls one or more plant pests or that improves at least one agronomic trait of interest in a plant. The bacterial strain can be used as an inoculant for plants. Methods for controlling a plant pest, for growing a plant susceptible to a plant disease, and for controlling plant disease on a plant susceptible to the plant disease are provided. Methods for improving at least one agronomic trait of interest in a plant are also provided.
Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by multiple bacterial genera (e.g., Brevibacillus, Lysinibacillus, Viridibacillus, and/or Paenibacillus family members) and methods of using the same are provided. The display of heterologous molecules, such as peptides, polypeptides and other recombinant constructs, on the exosporium of Brevibacillus, Lysinibacillus, Viridibacillus, and/or Paenibacillus family members, using particular N-terminal targeting sequences and derivatives of the same, and likewise are provided.
C12P 19/56 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
C12P 19/60 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
37.
GENETICALLY MODIFIED YEAST CELLS AND METHODS OF USE FOR INCREASED LIPID YIELD
Aspects of the disclosure are directed to genetically modified yeast cells and methods for use. Certain aspects are directed to recombinant yeast cells comprising exogenous nucleic acid sequences encoding phosphotransacetylase and/or phosphoketolase proteins, including a phosphoketolase protein from Clostridium acetobutylicum. Also disclosed are methods for generating recombinant yeast cells and methods of use of such cells for production of one or more products, including lipids, oils, fatty acids, and triacylglycerides.
The disclosure provides variant AAV capsid proteins and AAV capsids and virus vectors comprising the same. The virus vectors described herein may have increased transduction in a target cell of interest, such as a hematopoietic stem cell (HSC), compared to native AAV capsid sequences. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a patient in need thereof.
Aspects of the disclosure relate to production of vaccinia capping enzyme (VCE) in host cells. For example, host cells may comprise: a promoter; a ribosome binding site (RBS); a nucleic acid encoding a vaccinia capping enzyme (VCE) or VCE subunit; and a terminator.
Herbaspirillum bacterial strains are engineered to express or overexpress one or more proteins and/or attenuate expression of or delete one or more genes involved in nitrogen fixation and its regulation. This enables the diazotrophic bacteria to secrete more ammonia. The engineered bacteria arc introduced to agricultural plants, or seeds for growing such, forming a symbiotic relationship that results in increased nitrogen availability to the plant and improved plant agronomic traits.
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Downloadable electronic publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence Providing online non-downloadable publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and pharmaceutical and drug contaminants; detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, biosurveillance, bioinformatics, biointelligence, scientific research, and scientific diagnostics; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory services; scientific and technological research and development in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data collection, analysis, and reporting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing online non-downloadable software for viewing reports and delivering, accessing, sharing, analyzing, and visualizing data in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs Surveillance services, namely, surveillance of premises for viruses, pathogens, and pharmaceutical and drug contaminants
C12N 15/52 - Genes encoding for enzymes or proenzymes
C12P 19/56 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
C12P 33/20 - Preparation of steroids containing heterocyclic rings
The present disclosure provides chimeric antigen receptors, cells expressing such chimeric antigen receptors, compositions of cells expressing such chimeric antigen receptors, as well as methods of making and using the same.
The disclosure provides variant AAV capsid proteins and AAV capsids and virus vectors comprising the same. The virus vectors described herein may have increased transduction in a target cell of interest, such as a T-cell, compared to native AAV capsid sequences. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a patient in need thereof.
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Specifically, the disclosure is directed to a prenyltransferase variant, a chimeric prenyltransferase comprising one or more portions of at least two different prenyltransferase proteins, and a fusion polypeptide comprising a CBG-type producing prenyltransferase and farnesyl pyrophosphate synthase.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and pharmaceutical and drug contaminants; detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, biosurveillance, bioinformatics, biointelligence, scientific research, and scientific diagnostics; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory services; scientific and technological research and development in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data collection and analysis in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs. Surveillance services, namely, surveillance of premises for viruses, pathogens, and pharmaceutical and drug contaminants.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and pharmaceutical and drug contaminants; detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, biosurveillance, bioinformatics, biointelligence, scientific research, and scientific diagnostics; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and pharmaceutical and drug contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory services; scientific and technological research and development in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data collection and analysis in the fields of biosecurity, biosurveillance, bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs. Surveillance services, namely, surveillance of premises for viruses, pathogens, and pharmaceutical and drug contaminants.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable electronic publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable software for viewing reports and delivering, accessing, sharing, analyzing, and visualizing data in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data collection, analysis, and reporting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable electronic publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable publications in the nature of reports, white papers, and articles in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Providing online non-downloadable software for viewing reports and delivering, accessing, sharing, analyzing, and visualizing data in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; scientific and technological services, namely, data collection, analysis, and reporting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing scientific and technological information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence. Medical consulting in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; providing medical information in the fields of viruses, pathogens, pharmaceutical and drug contaminants, diagnostic testing, pandemic response, biosecurity, biosurveillance, bioinformatics, and biointelligence; all of the foregoing services based on information collected from bio-sample monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs.
51.
RECOMBINANT BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH METHIONINE METABOLISM AND METHODS OF USE THEREOF
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
The present disclosure relates to compositions and methods for reducing the concentration of extendable free and buried primers relative to amplification product in a sample. The disclosed methods and compositions can be used to reduce or eliminate index hopping in a next generation sequencing (NGS) platform.
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
C12P 19/60 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
C12P 23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
This disclosure provides expression systems comprising secretion signals that promote production and/or secretion of proteins of interest, as well as one or more polynucleotides encoding chaperone proteins (e.g., CRT and/or PDIA3) which, as demonstrate herein, enhance production and/or secretion of proteins. Moreover, genetically modified host cells comprising these expression systems are capable of producing high levels of protein of interest, such as bovine lactoferrin (bLF), bovine lactoglobulin (bLG), or ovalbumin (Ova).
C12N 15/62 - DNA sequences coding for fusion proteins
C07K 14/395 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi from yeasts from Saccharomyces
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein are described. Also described are methods of administering the virus vectors and virus capsids to a cell or to a subject in vivo.
The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/015 - Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
The present disclosure provides recombinant AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the recombinant AAV capsid proteins. The disclosure also provides methods of administering the virus vectors and vims capsids of the disclosure to a cell or to a subject in vivo.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro, and to variant terminal synthases having altered catalytic activity to synthesize THC-type, CBD-type and/or CBC-type cannabinoids.
Disclosed are transformed cells comprising one or more genetic modifications that affect the lipid content of the cell, e.g., by increasing the concentration of oleic acid in the cell relative to an unmodified cell of the same type. Also disclosed are methods for modifying the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the same cell.
Aspects of the disclosure relate to genetic modifications which increase heterologous protein production in a host cell, such as a methylotrophic yeast host cell, such as Pichia pastoris. Such genetic modifications may comprise, in some embodiments, one or more genetic modifications that result in (a) the expression of a mutant heat shock transcription factor 1 (HSF1); and/or (b) the downregulation of one or more genes SSY1, HSL1, PAS_chr2-l_0053, PAS_chr2-l_0404, PAS_chr4_0550, PAS_chrl-3_0135, and/or PAS_chrl-3_0285.
Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid. In certain embodiments, the plurality of blunt-end double-stranded nucleic acid fragments can be provided by: releasing a plurality of oligonucleotides synthesized on a solid support; and synthesizing complementary strands of the plurality of oligonucleotides using a polymerase based reaction.
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
Aspects of the disclosure relate to aromatic amino acid ammonia lyases (ALs), phenylalanine ammonia lyases (PALs), and tyrosine ammonia lyase (TALs), including engineered enzymes, and their use in catalyzing chemical reactions.
The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
A microfluidic chip comprising: a first port; a first microchannel having a first end connected to the first port and having a first portion with a spiral path around the first port; a membrane; and a second microchannel having a spiral portion adjacent to the first portion of the first microchannel and separated from the first microchannel by the membrane.
The current methods and compositions provide for nucleotide sequences of promoters from Yarrowia lipolytica which may be used to drive gene expression in a cell. In some aspects, the promoters are useful for modulating lipid production in oleaginous organisms such as yeast.
C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
68.
BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Described are host cells comprising heterologous polynucleotides encoding polyketide synthase (PKS) variants that are capable of producing more divarinol in the presence of butyrate.
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. In particular, the disclosure relates to variants of olivetolic acid cyclase.
The present disclosure relates to variants of SARS-CoV-2 nucleocapsid protein, spike protein, and spike protein receptor binding domain (RBD), as well as nucleic acids encoding such variants and methods of use thereof. Such variants are useful in diagnostic test kits and vaccines for SARS-CoV-2.
C07C 51/373 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
C07C 59/90 - Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
C12N 15/52 - Genes encoding for enzymes or proenzymes
The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in genes, such as PKP2, associated with arrhythmogenic cardiomyopathy. Also, provided herein are methods for treating and/or delaying the onset of arrhythmogenic cardiomyopathy.
This application describes transcriptional units, synthetic expression systems, and host cells comprising transcriptional units and synthetic expression systems, wherein the synthetic expression system is capable of expressing a gene of interest. Also described are methods for the production of bioproducts (including, but not limited to, proteins or RNA expressed from the gene of interest). In some embodiments, bioproducts are produced from host cells under culture conditions without addition of methanol.
Disclosed are new nucleic acid base-editing systems comprising fusion proteins comprising a) an RNA-programmable nucleic acid recognition module or other suitable nucleic acid recognition module, b) a light inducible reactive oxygen generator. Further disclosed are methods and kits to modify or mutagenize a target DNA region in prokaryotic or eukaryotic cells or organisms.
C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12P 13/00 - Preparation of nitrogen-containing organic compounds
C12N 15/52 - Genes encoding for enzymes or proenzymes
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
A61Q 13/00 - Formulations or additives for perfume preparations
C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
Described in this application are UDP-glycosyltransferases (UGT) enzymes, host cells expressing the UGTs, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such host cells.
C12N 15/52 - Genes encoding for enzymes or proenzymes
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12P 19/56 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Provided in this disclosure are engineered sesquiterpene synthases, host cells expressing engineered sesquiterpene synthases and methods for making alpha-guaiene.
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
C12P 17/06 - Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
C12P 7/22 - Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
C12M 1/40 - Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
C12Q 1/527 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving lyase
C12M 1/10 - Apparatus for enzymology or microbiology rotatably mounted
C12M 1/02 - Apparatus for enzymology or microbiology with agitation meansApparatus for enzymology or microbiology with heat exchange means
Aspects of the disclosure relate to phenylalanine ammonia lyase (PAL) enzymes, including engineered PAL enzymes, and their use in catalyzing chemical reactions.
e.g.e.g., a uric acid degrading enzyme, for the treatment of diseases and disorders associated with uric acid, including hyperuricemia and gout, in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with uric acid, such as hyperuricemia and gout.
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
Aspects of the disclosure relate to biosynthesis of histidine in host cells. For example, host cells may comprise: a promoter; a ribosome binding site (RBS); and a nucleic acid comprising: hisG; hisD; hisC hisB; hisH; hisA; hisF; and/or hisI. Host cells may further comprise a nucleic acid encoding a ribose phosphate pyrophosphokinase (RPPK), optionally comprising one or more amino acid substitutions relative to the sequence of wildtype E. coli RPPK. Host cells of the disclosure may comprise a nucleic acid encoding a 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase (MTHFDC) enzyme. Further aspects of the disclosure relate to production of purine pathway metabolites and/or plasmid DNA in host cells.
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs for viruses, pathogens, and
contaminants; detection of viruses, pathogens, and
contaminants in water, air, soil, surfaces, and human and
animal reservoirs; scientific and technological services,
namely, bio-sample testing services for others in the fields
of biosecurity, bioinformatics, scientific research, and
scientific diagnostics; scientific and technological
services, namely, biosecurity surveillance for analyzing
food, water, air, and environmental resource safety;
consulting services for others in the field of design,
planning, and implementation project management of
biosecurity initiatives related to the monitoring, testing,
and detection of viruses, pathogens, and contaminants in
water, air, soil, surfaces, and human and animal reservoirs;
scientific laboratory services; scientific and technological
research and development in the fields of biosecurity and
bioinformatics; providing scientific and technological
information in the fields of biosecurity and bioinformatics;
scientific and technological services, namely, data
collection and analysis in the fields of biosecurity and
bioinformatics; none of the foregoing being for agricultural
and horticultural use, imaging for medical purposes, or
photonics. Medical consulting in the fields of viruses, pathogens,
diagnostic testing, pandemic response, and biosecurity;
providing medical information in the fields of viruses,
pathogens, diagnostic testing, pandemic response,
biosecurity, and bioinformatics; the foregoing not related
to imaging for medical purposes.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Monitoring and testing of water, air, soil, surfaces, and
human and animal reservoirs for viruses, pathogens, and
contaminants; detection of viruses, pathogens, and
contaminants in water, air, soil, surfaces, and human and
animal reservoirs; scientific and technological services,
namely, bio-sample testing services for others in the fields
of biosecurity, bioinformatics, scientific research, and
scientific diagnostics; scientific and technological
services, namely, biosecurity surveillance for analyzing
food, water, air, and environmental resource safety;
consulting services for others in the field of design,
planning, and implementation project management of
biosecurity initiatives related to the monitoring, testing,
and detection of viruses, pathogens, and contaminants in
water, air, soil, surfaces, and human and animal reservoirs;
scientific laboratory services; scientific and technological
research and development in the fields of biosecurity and
bioinformatics; providing scientific and technological
information in the fields of biosecurity and bioinformatics;
scientific and technological services, namely, data
collection and analysis in the fields of biosecurity and
bioinformatics; none of the foregoing being for agricultural
and horticultural use, imaging for medical purposes, or
photonics. Medical consulting in the fields of viruses, pathogens,
diagnostic testing, pandemic response, and biosecurity;
providing medical information in the fields of viruses,
pathogens, diagnostic testing, pandemic response,
biosecurity, and bioinformatics; the foregoing not related
to imaging for medical purposes.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and contaminants; detection of viruses, pathogens, and contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, bioinformatics, scientific research on viruses, pathogens, and contaminants, and scientific diagnostics of viruses, pathogens and contaminants; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory research services in the fields of biosecurity and bioinformatics; scientific and technological research and development in the fields of biosecurity and bioinformatics; providing scientific and technological information in the fields of biosecurity and bioinformatics; scientific and technological services, namely, data collection and analysis in the fields of biosecurity and bioinformatics; none of the foregoing being for agricultural and horticultural use, imaging for medical purposes, or photonics.
(2) Medical consulting in the fields of viruses, pathogens, diagnostic testing, pandemic response, and biosecurity; providing medical information in the fields of viruses, pathogens, diagnostic testing, pandemic response, biosecurity, and bioinformatics; the foregoing not related to imaging for medical purposes.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Monitoring and testing of water, air, soil, surfaces, and human and animal reservoirs for viruses, pathogens, and contaminants; detection of viruses, pathogens, and contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific and technological services, namely, bio-sample testing services for others in the fields of biosecurity, bioinformatics, scientific research on viruses, pathogens, and contaminants, and scientific diagnostics of viruses, pathogens, and contaminants; scientific and technological services, namely, biosecurity surveillance for analyzing food, water, air, and environmental resource safety; consulting services for others in the field of design, planning, and implementation project management of biosecurity initiatives related to the monitoring, testing, and detection of viruses, pathogens, and contaminants in water, air, soil, surfaces, and human and animal reservoirs; scientific laboratory research services in the fields of biosecurity and bioinformatics; scientific and technological research and development in the fields of biosecurity and bioinformatics; providing scientific and technological information in the fields of biosecurity and bioinformatics; scientific and technological services, namely, data collection and analysis in the fields of biosecurity and bioinformatics; none of the foregoing being for agricultural and horticultural use, imaging for medical purposes, or photonics.
(2) Medical consulting in the fields of viruses, pathogens, diagnostic testing, pandemic response, and biosecurity; providing medical information in the fields of viruses, pathogens, diagnostic testing, pandemic response, biosecurity, and bioinformatics; the foregoing not related to imaging for medical purposes.
The disclosure relates to enzymes, such as cucurbitadienol synthase (CDS), UDP-glycosyltransferase (UGT), C11 hydroxylase, epoxide hydrolase (EPH), squalene epoxidase (SQE), and/or cytochrome P450 reductase enzymes, recombinant host cells expressing the enzymes, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such recombinant cells.
DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for expression in an oleaginous yeast host of polynucleotide sequences encoding DGA1 from Rhodosporidium toruloides, Lipomyces starkeyi, Aurantiochytrium limacinum, Aspergillus terreus, or Claviceps purpurea. Also described herein are engineered recombinant host cells of Yarrowia lipolytica comprising heterologous DGA1 polynucleotides encoding DGA1 proteins, or functionally active portions thereof, having the capability of producing increased lipid production and possessing the characteristic of enhanced glucose consumption efficiency.
The disclosure relates to methods and compositions for the production of fructans using sucrose:sucrose 1-fructosyl-transferase (1-SST), fructan:fructan 1-fructosyltransferase (1-FFT), and/or sucrose fructan-6-fructosyltransferase (6-SFT) enzymes.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
98.
INTERGENERIC ENDOSPORE DISPLAY PLATFORMS, PRODUCTS AND METHODS
BrevibacillusLysinibacillusViridibacillusPaenibacillusBrevibacillusLysinibacillusViridibacillusPaenibacillus Paenibacillus family members, using particular N-terminal targeting sequences and derivatives of the same, and likewise are provided.
The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of leucine, isoleucine, and/or valine using the pharmaceutical compositions disclosed herein.
Described in this disclosure are rare earth element (REE)-binding proteins (e.g., lanthanide-binding proteins), host cells expressing the REE-binding proteins, and methods of recovering REEs.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
C22B 3/18 - Extraction of metal compounds from ores or concentrates by wet processes with the aid of microorganisms or enzymes, e.g. bacteria or algae
