C07C 47/565 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
C07C 59/215 - Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen-containing groups
C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
2.
Process for the preparation of rucaparib and novel synthesis intermediates
Advitech Advisory and Technologies SA (Switzerland)
Inventor
Beck, Brent Christopher
Perales, Joe B.
Speake, Jason D.
Ferrando, Ilaria
Abstract
The present invention relates to a process for the preparation of rucaparib; the invention also refers to novel intermediates of synthesis as well as their use in the preparation of i.a. rucaparib.
C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
C07D 403/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
3.
PROCESS FOR THE PREPARATION OF RUCAPARIB AND NOVEL SYNTHESIS INTERMEDIATES
ADVITECH ADVISORY AND TECHNOLOGIES SA (Switzerland)
Inventor
Beck, Brent Christopher
Perales, Joe B.
Speake, Jason D.
Ferrando, Ilaria
Abstract
The present invention relates to a process for the preparation of rucaparib; the invention also refers to novel intermediates of synthesis as well as their use in the preparation of i.a. rucaparib.
C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
C07D 403/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
C07C 243/22 - Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
C07C 323/22 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
C07C 47/56 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing hydroxy groups
C07C 51/367 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
C07C 59/74 - Unsaturated compounds containing —CHO groups
patents
