Cosmetic use of a composition for reducing and/or ameliorating signs of skin aging in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted Formula II is a single bond, R4 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted Formula II is a double bond, X is hydrogen or a glycosyl moiety, wherein the glycosyl moiety is a lactosyl moiety or a glucosyl moiety.
Cosmetic use of a composition for reducing and/or ameliorating signs of skin aging in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted Formula II is a single bond, R4 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted Formula II is a double bond, X is hydrogen or a glycosyl moiety, wherein the glycosyl moiety is a lactosyl moiety or a glucosyl moiety.
A method for production of at least one sphingolipid of formula (1), or a composition thereof. The method comprising reacting at least one lysosphingolipid of formula (2), or a salt thereof: with a compound of formula (3): wherein W, R1, R2, R3, and R4are as defined as for the sphingolipid of formula (1), and wherein, said reacting is performed in the presence of a base of formula (4): wherein n is 1, 2, or 3; m is 1 or 2; X is selected from Na+44 +, Mg2+, or Ca2+; Y is selected from OH-33 2-33 -44 3-, methoxide, acetate, citrate, or succinate.
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 15/06 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical being a hydroxyalkyl group esterified by a fatty acid
The present invention relates to a novel glycosynthase, especially an endoglycoceramide synthase, and to a method for the glycosylation of sphingolipids.
The present invention relates to a novel and efficient method for the production of glycosyl fluorides by the fluorination of a protected saccharide with a fluorinating agent, such as poly(hydrogen fluoride), triethylamine trihydrofluoride, and DMPU-HF, wherein the fluorination is performed in the presence of a Lewis acid.
C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
C07H 15/18 - Acyclic radicals, substituted by carbocyclic rings
The present invention relates to a cosmetic use of a composition for boosting skin cell energy metabolism in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, X is hydrogen, a glucosyl moiety or a lactosyl moiety.
The present invention relates to a cosmetic use of a composition for boosting skin cell energy metabolism in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, X is hydrogen, a glucosyl moiety or a lactosyl moiety.
A composition comprising one or more compounds of formula (1), or salts thereof: (1) wherein R1 is a C13-C17 alkyl chain; R2 is a C15-C19 alkyl chain, preferably C18; and R3 is a glycosyl moiety selected from Neu5Acα2-3-Galβ1-4-Glcβ1-, or Neu5Acα2-8-Neu5Acα2-3- Galβ1-4-Glc β1-. Child nutritional formulas containing the composition are also provided.
A composition comprising one or more compounds of formula (1), or salts thereof: (1) wherein R1131717 alkyl chain; R215191818; and R3 is a glycosyl moiety selected from Neu5Acα2-3-Galβ1-4-Glcβ1-, or Neu5Acα2-8-Neu5Acα2-3- Galβ1-4-Glc β1-. Child nutritional formulas containing the composition are also provided.
The present invention relates to a method of producing a compound of formula (1): (1) from a compound of formula (2): (2), wherein R11-501-1710-1710-17 alkyl, R2is hydrogen or -OR5, wherein R51-3- - -- - - may be a double or a single bond when R2is H, or is a single bond when R2is -OR5, R32-42-4 alkyl, R4is hydrogen or -C(=O)R6, wherein R6153333 alkyl, Glc is a glucosyl moiety, Gal is galactosyl moiety, wherein the method comprises a step of reacting the compound of formula (2) with an enzyme having β-galactosidase activity.
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
Composition comprising Glycosphingolipids for young child applications This invention relates to compositions comprising one or more glycosphingolipids, to child nutritional formulas which contain said compositions, to uses of said compositions for supporting healthy growth and development of young children, in particular, infants and toddlers, and dietary management of symptoms associated with inflammation of the gastrointestinal system of said young children. In particular, the invention relates to a composition comprising one or more compounds of formula (1), or salts thereof: wherein R1131717 alkyl chain; R2151919 alkyl chain; and R3 is a glycosyl moiety selected from Neu5Acα2-3-Galβ1-4-Glcβ1-, or Neu5Acα2-8-Neu5Acα2-3-Galβ1-4-Glc β1-. Child nutritional formulas containing the composition are also provided.
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
B01D 1/18 - Evaporating by spraying to obtain dry solids
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
The present invention describes a novel method for the isolation of a glycosphingolipid lacking the amide-linked fatty acyl group, the method comprising the steps of: providing a solution comprising said glycosphingolipid of formula (1) or a salt thereof, and one or more contaminants, diafiltration of said solution, thereby obtaining a diafiltration retentate (DFR) comprising said glycosphingolipid, or salt thereof, by using a membrane having a MWCO of 100-300 kDa, thereby isolating said glycosphingolipid or salt thereof from the one or more contaminants.
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
B01D 1/18 - Evaporating by spraying to obtain dry solids
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
The present invention relates to a method for the production of a sialylated glycosphingolipid, the method comprising the steps of: ─ providing a glycosphingolipid, a sialic acid donor, and an enzyme having a trans-sialidase activity, ─ mixing said glycosphingolipid with said sialic acid donor in the presence of said enzyme having trans-sialidase activity, thereby producing said sialylated glycosphingolipid, and wherein the sialic acid donor is 3´-sialyllactose.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
The present invention relates to a novel and efficient method for the production of sphingolipids via the N-acylation of lysosphingolipids. The method comprises the use of 1,3,5-triazine-based acylating agents, and is especially suitable for the production of ceramides and glycosphingolipids. The present invention further relates to novel 1,3,5-triazine-based acylating agents.
The present invention relates to a use of a composition comprising a compound of formula I, wherein R1is an alkyl chain having 10 - 20 carbon atoms, R2 is an acyl having 16-34 carbon atoms, X is hydrogen, a glucosyl moiety or a lactosyl moiety for promoting hair growth or for preventing hair loss on skin of a subject.
The present invention relates to a topical composition comprising one or more compounds of formula (I), wherein X is hydrogen or a glycosyl moiety, the carbon-carbon bond noted is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, said composition is characterized in that at least one of the one or more compounds of formula (I) has a lactosyl moiety or a glucosyl moiety in the position X.
The present invention relates to a topical composition comprising one or more compounds of formula (I), wherein X is hydrogen or a glycosyl moiety, the carbon-carbon bond noted is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, said composition is characterized in that at least one of the one or more compounds of formula (I) has a lactosyl moiety or a glucosyl moiety in the position X.
A61K 8/68 - Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):
The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):
or a salt thereof,
wherein
R1 is hydrogen, a C1-50 alkyl, preferably a C1-15 alkyl, more preferably a C10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group,
with a compound of formula (3):
The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):
or a salt thereof,
wherein
R1 is hydrogen, a C1-50 alkyl, preferably a C1-15 alkyl, more preferably a C10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group,
with a compound of formula (3):
The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):
or a salt thereof,
wherein
R1 is hydrogen, a C1-50 alkyl, preferably a C1-15 alkyl, more preferably a C10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group,
with a compound of formula (3):
wherein
the bond represents a double or a single bond,
W is C, or C(OR4),
Z is O, or OR5,
provided that:
when W is C, the bond is a double bond and Z is O, or
when W is C(OR4), the bond is a single bond and Z is OR5, and
wherein
R2 and R3 are independently selected from a saturated or unsaturated C1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein one of R2 and R3 is hydrogen, and the other rest is a saturated or unsaturated C1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein R2 and R3 may form a cyclic structure,
R4 and R5 are independently selected from a C1-6 alkyl, a cycloalkyl, or an aryl, each of which may be substituted or unsubstituted.
C07C 213/08 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 213/10 - SeparationPurificationStabilisationUse of additives
C07C 215/24 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
C07C 249/02 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
C07C 251/24 - Compounds containing nitrogen atoms doubly- bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
C07D 207/325 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C07D 265/06 - 1,3-OxazinesHydrogenated 1,3-oxazines not condensed with other rings
C07D 319/06 - 1,3-DioxanesHydrogenated 1,3-dioxanes not condensed with other rings
Cosmetic use of a composition for reducing and/or ameliorating signs of skin aging in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1is an alkyl chain having 10 - 20 carbon atoms, R2is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R3is - OH when the carbon-carbon bond noted Formula II is a single bond, R4is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R4 is hydrogen or -OH when the carbon-carbon bond noted Formula II is a double bond, X is hydrogen or a glycosyl moiety, wherein the glycosyl moiety is a lactosyl moiety or a glucosyl moiety.
The present invention relates to a novel and efficient method for the production of glycosyl fluorides by the fluorination of a protected saccharide with a fluorinating agent, such as poly(hydrogen fluoride), triethylamine trihydrofluoride, and DMPU-HF, wherein the fluorination is performed in the presence of a Lewis acid.
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
The present invention relates to a cosmetic use of a composition for boosting skin cell energy metabolism in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1is an alkyl chain having 10 - 20 carbon atoms, R2is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R3is -OH when the carbon-carbon bond noted is a single bond, R4is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R4 is hydrogen or -OH when the carbon-carbon bond noted is a double bond, X is hydrogen, a glucosyl moiety or a lactosyl moiety.
The present invention relates to a biotechnological method for producing a C-glycoside of interest. The invention further relates to the use of a sialylated C-glycoside as a donor in an enzymatic glycosylation reaction. The present invention further relates to the following C- glycosides.
Neritroeritroeritro-sphingosine, analogues thereof, or salts thereof. The method comprises the use of esters as acylating agents and is especially suitable for the production of ceramides.
C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/20 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
The present invention relates to a novel glycosynthase, especially an endoglycoceramide synthase, and to a method for the glycosylation of sphingolipids.
The present invention relates to a novel and efficient method for the production of sphingolipids via the N-acylation of lysosphingolipids. The method comprises the use of 1,3,5-triazine-based acylating agents, and is especially suitable for the production of ceramides and glycosphingolipids. The present invention further relates to novel 1,3,5-triazine-based acylating agents.The acylating agents have the following Formula (3), wherein (A) represents a conjugated system of bonds such that either two or three double bonds are present in the ring; Y is selected from C(O-C(=O)R4), or C(=O); Xais selected from N, NR6, or N(C(=O)R4); Xbis selected from N, or NR6; Z is selected from C(=O), or C(OR6); and provided that: when Y is C(O-C(=O)R4), Z is C(OR6), Xaand Xbare N, and three double bonds are present in the ring, or when Y is C(O-C(=O)R4), Z is C(=O), one of Xaand Xbis N and the other group is NR6, and two double bonds are present in the ring, or when Y is C(=O), Z is C(OR6), Xais N(C(=O)R4), Xbis N, and two double bonds are present in the ring; and wherein R4is as defined as for the sphingolipid of formula (1), R6 is selected from methyl, ethyl, 2,2,2-trifluoroethyl, and substituted or unsubstituted benzyl.
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
C07D 251/12 - Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
The present invention relates to a method for producing a glycosyl fluoride of interest, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can be performed on the exogenous precursor in the genetically modified cell, the genetically modified cell comprising one or more nucleic acid sequences encoding one or more glycosyltransferase enzymes. The present invention further relates to a compound of the following formula: 2b.
The present invention relates to a method for producing a glycosyl fluoride of interest, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can be performed on the exogenous precursor in the genetically modified cell, the genetically modified cell comprising one or more nucleic acid sequences encoding one or more glycosyltransferase enzymes. The present invention further relates to a compound of the following formula: 2b.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
The present invention relates to a method for producing a glycosylated sphingoid base of interest or an analogue thereof, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can be performed on the exogenous precursor in the genetically modified cell, the genetically modified cell comprising one or more nucleic acid sequences encoding one or more glycosyltransferase enzymes.
C12P 19/44 - Preparation of O-glycosides, e.g. glucosides
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
--- --- is a double or a single bond, R1is an alkyl chain having 10 - 20 carbon atoms, R2is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 ------ is a double or a single bond, and R3 ------ is a single bond, R4 ------ is a double or a single bond, and R4 --- --- is a double bond, said composition is characterized in that at least one of the one or more compounds of formula (I) has a lactosyl moiety or a glucosyl moiety in the position X.
1-501-1510-1510-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group, with a compound of formula (3): Formula (3), wherein the bond represents a double or a single bond, W is C, or C(OR4), Z is O, or OR5, provided that: when W is C, the bond is a double bond and Z is O, or when W is C(OR4), the bond is a single bond and Z is OR5, and wherein R2and R31-61-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein one of R2and R31-61-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein R2and R3may form a cyclic structure, R4and R51-61-6 alkyl, a cycloalkyl, or an aryl, each of which may be substituted or unsubstituted.
C07C 213/08 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 215/10 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
C07C 251/54 - Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07D 207/323 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
C07D 265/06 - 1,3-OxazinesHydrogenated 1,3-oxazines not condensed with other rings
C07D 319/06 - 1,3-DioxanesHydrogenated 1,3-dioxanes not condensed with other rings
The present invention relates to several novel 1-O-glycosylated sphingoid bases and to a production method thereof, as well as to uses of the 1-O-glycosylated sphingoid bases.
Sphingoid bases carrying a vinylogous amide-type protecting group are used herein for the production of 1-O-glycosylated sphingoid bases. These vinylogous amide compounds enable an easy and effective production of 1-O-glycosylated sphingoid bases.
C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
The present invention relates to a method for producing a glycosyl fluoride of interest, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can be performed on the exogenous precursor in the genetically modified cell, the genetically modified cell comprising one or more nucleic acid sequences encoding one or more glycosyltransferase enzymes. The present invention further relates to a compound of the following formula: 2b.
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
The present invention relates to a biotechnological method for producing a C-glycoside of interest. The invention further relates to the use of a sialylated C-glycoside as a donor in an enzymatic glycosylation reaction. The present invention further relates to the following C- glycosides.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C07H 17/04 - Heterocyclic radicals containing only oxygen as ring hetero atoms
C12P 19/44 - Preparation of O-glycosides, e.g. glucosides
C12P 19/60 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
35.
SYNTHESIS OF GLYCOSYLATED SPHINGOID BASES OF INTEREST OR ANALOGUES THEREOF
The present invention relates to a method for producing a glycosylated sphingoid base of interest or an analogue thereof, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can be performed on the exogenous precursor in the genetically modified cell, the genetically modified cell comprising one or more nucleic acid sequences encoding one or more glycosyltransferase enzymes.
C12P 19/44 - Preparation of O-glycosides, e.g. glucosides
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
The present invention relates to sphingolipids, a method for the production of sphingoid bases, especially sphingosine, and novel derivatives thereof. The sphingoid bases are herein produced by making use of a vinylogous amide-type protecting group. The resulting vinylogous amide compounds enable an easy and effective production of sphingoid bases, especially sphingosine.
C07D 239/60 - Three or more oxygen or sulfur atoms
C07C 213/08 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
The present invention relates to sphingolipids, and more particularly to a method for the production of sphingoid bases, especially sphingosine, and novel derivatives thereof. The sphingoid bases are herein produced by making use of a vinylogous amide-type protecting group. The resulting vinylogous amide compounds enable an easy and effective production of sphingoid bases, especially sphingosine.
C07C 215/24 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
C07D 239/60 - Three or more oxygen or sulfur atoms
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
38.
GLYCOSYLATED SPHINGOID BASES AND PRODUCTION THEREOF
The present invention relates to several novel 1-O-glycosylated sphingoid bases and to a production method thereof, as well as to uses of the 1-O-glycosylated sphingoid bases. Sphingoid bases carrying a vinylogous amide-type protecting group are used herein for the production of 1-O-glycosylated sphingoid bases. These vinylogous amide compounds enable an easy and effective production of 1-O-glycosylated sphingoid bases. The sphingoid bases carrying a vinylogous amide-type protecting group have formulas l-lll below: General Formula I, General Formula II, General Formula III.
C07H 15/02 - Acyclic radicals, not substituted by cyclic structures
C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
C07H 1/00 - Processes for the preparation of sugar derivatives
C07D 247/02 - Heterocyclic compounds containing rings having two nitrogen atoms as the only ring hetero atoms, according to more than one of groups having the nitrogen atoms in positions 1 and 3
C07C 215/00 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton
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