Abstract

　The purpose of the present invention is to provide an anti-inflammatory agent containing a novel component capable of suppressing inflammation and having high safety. The present invention provides an anti-inflammatory agent using a low-molecular-weight polysaccharide from Aphanothece sacrum, the polysaccharide being derived from sacran extracted from Aphanothece sacrum. The low-molecular-weight polysaccharide from Aphanothece sacrum is a sugar derivative containing a sulfated sugar having a weight average molecular weight of approximately 3,000,000 or less, the sugar derivative being derived from sacran. The present invention provides a pharmaceutical composition, especially a dermal topical anti-inflammatory, containing a low-molecular-weight polysaccharide from Aphanothece sacrum.

IPC Classes  ?

• A61K 31/737 - Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
• A61K 36/02 - Algae
• A61P 17/00 - Drugs for dermatological disorders
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 37/08 - Antiallergic agents

Abstract

A process for the preparation of an Aphanothece sacrum-originated polysaccharide with a reduced trivalent metal content, which includes treating Aphanothece sacrum with an acid; an Aphanothece sacrum-originated polysaccharide with a reduced trivalent metal content, which is obtained by the process; and a wound-protective agent and an anti-allergic dermatitis agent, which each contain the Aphanothece sacrum-originated polysaccharide with a reduced trivalent metal content.

IPC Classes  ?

• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61K 36/02 - Algae
• A61L 15/16 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 37/08 - Antiallergic agents

Abstract

A sugar derivative derived from Aphanothece sacrum as a freshwater blue-green alga, having a mean molecular weight of 2,000,000 or more and a repeat structure of a sugar chain unit where a sugar constituent of a hexose structure and a sugar constituent of a pentose structure are conjugated together in a linear chain or a branched chain, containing a lactated, sulfated sugar as a constituent, where 2.7 or more hydroxyl groups per 100 hydroxyl groups are sulfated or sulfur element occupies 1.5% by weight or more of all of the elements, in the sugar chain unit. A sugar derivative with a novel polysaccharide structure as derived from Aphanothece sacrum is provided in such manner.

IPC Classes  ?

• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61K 31/737 - Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
• A61K 31/738 - Cross-linked polysaccharides
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• C08B 5/06 - Isolation of the cellulose nitrate
• C07H 5/06 - Aminosugars