Abstract

A protein specifically binding to human TNFα (tumor necrosis factor α) is disclosed, i.e. human anti-TNFα monoclonal antibody derived from human B cells. The light and heavy chain of the antibody have the amino acid sequence as shown in SEQ ID NO: 3 and SEQ ID NO: 4, respectively. Also disclosed are the encoded sequences of the human anti- TNFα antibody, its Fab antibody and the peglated Fab antibody. The present invention further provides the uses of the antibodies in the preparation of the medicament for treatment of TNFα-related inflammation.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/13 - Immunoglobulins
• C12N 5/24 - Human cells one of the fusion partners being a B lymphocyte
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]